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presence of angiostrongylus cantonensis at la réunion.the eosinophilic meningitis due to angiostrongylus cantonensis is well known on madagascar and on mauritius island, but was never described on reunion island. two cases have been lately oberved in doctor jay's department at gabriel martin's hospital. local achatines were dissected and contained larvae which, when absorbed by rats, were found in there brains ten days later. these larvae belong certainly to angiostrongylus genus, but the species has not yet been found with certitude. lately infest ...19757126
angiostrongylus cantonensis: preparation of a specific antigen using immunoadsorbent columns. 197551799
the humoral and cell-mediated immune responses to somatic and metabolic antigens in rats infected with angiostrongylus cantonensis. 197886211
occurrence of angiostrongylus cantonensis in the heart of a spider monkey. 1978102677
effects of various numbers of adult angiostrongylus cantonensis on lung lysophospholipase activities and bone marrow eosinophil levels of specific pathogen-free rats. 1978153956
hexokinase of angiostrongylus cantonensis: presence of a glucokinase.1. angiostrongylus cantonensis contains a glucokinase which was isolated by deae-cellulose column chromatography. 2. this enzyme has a much higher affinity toward glucose (apparent km, 0.2 mm) than fructose (apparent km, 85 mm). glucose-6-phosphate (10 mm) does not inhibit glucose phosphorylation. 3. molecular weight obtained by a molecular sieve chromatography (60,000) is also close to the value of mammalian glucokinase. 4. while vmax value for mannose is one-third smaller than that for glucose ...1979318415
de novo purine ribonucleotide biosynthesis in adult angiostrongylus cantonensis (nematoda: metastrongyloidea).1. radioactivity was found to be associated with purine ribonucleotides in extracts of gravid adult angiostrongylus cantonensis from the lungs of rats when the parasite was incubated in a medium containing [14c]glycine. 2. the rate of incorporation was at least 0.2 pmole/min per mg of parasite and approximately equal amounts of adenine and guanine ribonucleotides were synthesized. 3. this is the first demonstration of the capacity for a mammalian parasitic helminth to synthesize purines de novo.1979318440
immunodiagnosis of parasitic zoonoses: comparative efficacy of three immunofluorescence tests using antigens purified by affinity chromatography.three immunofluorescent antibody assays were developed during this study: the direct (dfat) and indirect (ifat) fluorescent antibody tests using frozen worm sections, and the cyanogen bromide indirect fluorescent antibody test (cnbr-ifat) using helminth antigens purified by affinity chromatography bound on to commercially prepared cnbr-sepharose 4b beads. purified antigens used in the cnbr-ifat gave greater specificity and sensitivity than either the dfat or ifat. dirofilaria immitis, toxocara c ...1978354114
food-borne parasitic infections--old stories and new facts.a review is presented of food-borne parasitic infections. parasitic infections with public health hazards both from conventional slaughter animals and from seafood (fish and shellfish) are discussed. the former category includes cysticercosis, echinococcosis, and trichinosis, the latter category covers various trematode, cestode, nematode, and possibly also protozoan infections. examples of trematode infections are heterophyidiasis, transmitted to man by marine fish, and paragonimus spp parasite ...1979369034
eosinophilic meningitis: a suspected case of angiostrongylosis found in shizuoka prefecture, honshu, japan.a patient with eosinophilic meningitis in shizuoka prefecture, honshu, japan had nausea, vomiting and headache on admission; laboratory examinations revealed leukocytosis with eosinophilia. eight days later neck stiffness appeared. lumbar puncture showed an increase of the initial pressure in association with eosinophilic pleocytosis in the spinal fluid. the possibility of angiostrongylosis was considered because the patient had eaten raw slugs for 4 years as a remedy for lumbago. although the s ...1979434313
transplantation of young adult angiostrongylus cantonensis into the rat pulmonary vessels and its application to the assessment of acquired resistance. 1979437939
changes in worm burden, haematological and serological response in rats after single and multiple angiostrongylus cantonensis infections.thirteen groups of rats were first sensitized with single or double doses of 5--30 third-stage larvae of angiostrongylus cantonensis, followed by a challenge infection with 100 larvae at various periods after the primary infection. seven other groups of rats receiving only the sensitizing infection served as the controls. in all the sensitized rats, a significantly (p less than 0.05) smaller mean number of adult worms was found established in the challenge infection as compared to the control. t ...1979452645
host-parasite relationship of angiostrongylus cantonensis. 1. intracranial transplantation into various hosts.various stages of angiostrongylus cantonensis recovered from the brain of experimentally infected mice were transplanted intracranially into rats. third and fourth-stage worms recovered 2--7 days postinfection were able to develop normally after transplantation into recipient rats. the fifth-stage worm obtained 14--15 days postinfection would enter the brain tissue of rats but died shortly afterwards. however, the same stage of worms recovered from rats, after a similar transplantation, were fou ...1979479541
effect of vitamin a deficiency on susceptibility of rats to angiostrongylus cantonensis. 1979482296
angiostrongylus cantonensis: infectivity of first stage larvae in the presence of rat fecal materials as tested by the in vitro cultivation technique. 1979483014
cross-resistance between trichinella spiralis and angiostrongylus cantonensis in laboratory rats. 1979494711
studies on susceptibility of pila ampullacea, to the infection with the rat lungworm, angiostrongylus cantonensis.experimental infections of pila ampullacea with first stage larvae of angiostrongylus cantonensis were carried out to determine susceptibility of this molluscan host in relation to dose level and snail host size. snails were divided into 3 size groups and exposed to a. cantonensis first stage larval suspensions of varying concentrations. the results showed that overall, about 20% of larvae ingested by the snails developed into infective third stage larvae, but the percentage was inversely relate ...1979538501
nematode parasites of rats in west java, indonesia.from the indonesian rats, namely rattus rattus diardii, r. exulans, r. tiomanicus, r. niviventer, r. lepturus, r. bartelsii, r. cremoriventer, r. sabanus and pithecheir melanurus, surveyed for nematode parasites, the following parasites were recovered: angiostrongylus cantonensis, capillaria hepatica, cyclodontostomum purvisi, hepatojarakus malayae, rictularia tani, mastophorus muris, physaloptera sp. and subulura andersoni. of these, c. purvisi, h. malayae, physaloptera, sp. and s. andersoni ha ...1978571622
[1st case of eosinophilic meningitis in reunion, probably due to angiostrongylus].report of the case of a six-year-old child who presented a meningitis with 40 % eosinophils in the cerebrospinal fluid and which spontaneously regressed. these clinical data and the serologic (positive test for many nematod antigens) and epidemiological findings (presence of angiostrongylus larvae in terrestrial gasteropod) lead to the conclusion that we were in presence of the first case of eosinophil meningitis due to angiostrongylus cantonensis reported in the island of la réunion.1977579615
commercially available, edible snails otala lactea (müller) and helix aperta (born) as laboratory hosts of angiostrongylus cantonensis. 1977592047
epidemiological survey of angiostrongylus cantonensis in shimizu ship-port, shizuoka prefecture, japan. 1977598977
effect of immunization with metabolic antigens on experimental infection of rats with angiostrongylus cantonensis.immunization of rats with excretions and secretions from an in vitro culture fluid (es antigens) of adult female angiostrongylus cantonensis markedly enhanced their resistance to infection by third-stage larvae. mortality rate, survival period, worm development and worm recovery, determined after a lethal challenge with infective larvae, were compared in immunized and unimmunized animals. with regard to these criteria, the results obtained with animals that had been immunized with es antigens fr ...1977614709
"commercially available, edible snails otala lactea (müller) and helix aperta (born) as laboratory hosts of angiostrongylus cantonensis". 1978627973
acetylcholinesterase levels in angiostrongylus cantonensis in relation to the immune response in rats. 1978631982
nidality of eosinophilic meningitis with special reference to angiostrongylus cantonensis. 1978632707
the first record of angiostrongylus cantonensis from egypt.in this paper the first record of the medically important nematode parasite, angiostrongylus cantonensis, is made from egypt. a survey of eight species of freshwater gastropods collected from natural water courses and of three species of wild rats caught from the same areas revealed respectively, that the ampullarid snail lanistes carinatus acts as the intermediate host transmitting this parasite, and that the rat rattus norvegicus is its definitive host. the life cycle of the parasite was succe ...1978706552
[eosinophilic meningoencephalitis caused by angiostrongylus cantonensis: a case report (author's transl)]. 1978709966
transplantation of intracranial young adult angiostrongylus cantonensis into the subdural spaces of the brains of rats and guinea pigs. 1978713222
observations on the development of angiostrongylus cantonensis in mastomys and mongolian gerbils. 1978723108
effects of parasitism and stress on hemolymph protein of the african giant snail, achatina fulica.effects of parasitism and stress on the protein concentration of hemolymph have been investigated using the rat lungworm angiostromgylus cantonensis in the snail host achatina fulica. the normal hemolymph protein concentration, averaging 1.77 g/100 ml in noninfected snails, did not show any reduction when the hosts were infected with third stage larvae. when the infected snails were bled repeatedly, protein concentration showed a significant decrease by 0.6 g/100 ml. starved, infected snails wer ...1978735303
angiostrongyliasis in indonesia: additional geographic and host occurrence records.geographical and host occurrence records for angiostrongylus cantonensis throughout the indonesian archipelago a;e reported. a. cantonensis was found in the following provinces: west sumatra, south sumatra, lampung, west java, central java, north sulawesi and east nusa tenggara. infections were diagnosed in the following rodents: rattus rattus diardii, rattus exulans, rattus tiomanicus jaloriensis, rattus lepturus, rattus norvegicus and bandicota indica setifera and in the giant african land sna ...1978751218
parasitic diseases of the nervous system in thailand.in thailand there are 3 parasites that commonly cause neurological diseases in man. 1) in gnathostomiasis man becomes an accidental host by eating infected under-cooked fresh water fish. the tissue nematode involved, gnathostoma spinigerum, because of its high motility, may cause widespread damage in the spinal cord and brain stem. the common presenting neurological symptoms are severe nerve root pain, paralysis of limbs and urinary retention. less frequently seen are cranial nerve palsies and s ...1978756025
[histological studies of the african giant snail (achatina fulica) experimentally infected with angiostrongylus vasorum or angiostrongylus cantonensis (author's transl)].african giant snails (achatina fulica) about 6 weeks old were experimentally infected with each 5,000 to 20,000 first stage larvae of angiostrongylus vasorum or a. cantonensis by exposure to a larval suspension. the snails were histologically examined after various intervals after infection: 1 hour post infectionem (p.i.) larvae were present in the foot and 2 hours p.i. in addition in the gastrointestinal tract. 12 hours p.i. larvae were seen for the first time in the lung which reached nearly h ...1976790803
eosinophilic meningoencephalitis caused by the rat lung worm, angiostrongylus cantonensis with special reference to a. malaysiensis in malaysia. 1976822262
angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge.rats given an initial infection with angiostrongylus cantonensis had moderately elevated phospholipase b activity in the lungs at 8 and 15 days after challenge, and greatly elevated levels were evident at 35, 43, and 49 days. in the brain, the values were elevated at 15 through 35 days. these periods of increased activity in the lungs and brain coincided with the migration patterns of the third stage larvae and the adult worms in this host. the elevated enzyme levels also were were correlated wi ...1977832897
ocular angiostrongyliasis in semarang, central java.a worm removed intact from the anterior chamber of the left eye of a 23-year-old woman from central java was identified as a mle angiostrongylus cantonensis, 11.1 mm in length and 0.24 mm in maximum width. a useful degree of eye function was preserved. five similar cases have been reported--three from thailand, two from south vietnam.1977842785
the mode of infection with and the distribution of angiostrongylus cantonensis larvae in the experimental intermediate hoist biomphalaria glabrata. 1977919700
letter: granulomatous encephalomyelitis of puppies due to angiostrongylus cantonensis. 1976971151
reaginic antibody productions in rabbits and rats infected with angiostrongylus cantonensis. 1976985982
growth and localization of angiostrongylus cantonensis in the molluscan host, achatina fulica.the development of the rat lung worm angiostrongylus cantonensis within the giant african snail achatina fulica is reported. in this host, ingested first stage larvae penetrate the intestinal wall into the hemocoel and migrate to the mantle where they undergo two molts and become third stage larvae within 24 days. the mantle, harboring 85% of the total number recovered is the major location of infective larvae. the kidney contains about 11% but few larvae are found in the remaining visceral org ...19761027104
the bandicoot rat, a new host record for angiostrongylus cantonensis in indonesia.a survey for angiostrongylus cantonensis in possible definitive and intermediate hosts was conducted in ancol, jakarta. adult worms were found in 43% of bandicoot rats, bandicota indica setifera, in 14% of rattus rattus diardii and 36% of the achatina fulica were infected with larval forms of the parasite. the finding of the parasite in the bandicoot rat constitutes a new host record for indonesia.19761027106
delayed hypersensitivity responses of guinea pig and rat to angiostrongylus cantonensis infection. 19761034844
angiostrongylus cantonensis in rats on makung, pescadores islands (peng hu). 19761037538
angiostrongyliasis cantonensis (eosinophilic meningitis, alicata's disease).angiostrongyliasis is an infectious disease caused by nematode parasites of the genus angiostrongylus. the rat lung worm angiostrongylus cantonensis, primarily a parasite of rodents, is largely responsible for human cases of eosinophilic meningitis, or meningoencerphalitis, which occurs on many pacific islands and in southeast asia. the disorder, which frequently occurs in epidemic extent, is caused by invasion of the central nervous system by developing larvae of the parasite. the infection is ...19751095293
comparative studies on the life history of angiostrongylus mackerrasae bhaibulaya, 1968 and angiostrongylus cantonensis (chen, 1935). 19751112632
eosinophilic meningitis (angiostrongylosis): a probable case.a probable case of eosinophilic meningitis is described. this report is thought to be the first of a case of this disorder diagnosed in new south wales, although infection probably occurred in queensland. the life cycle of the parasite angiostrongylus cantonensis is outlined briefly and the clinical manifestations of this disease are discussed. treatment with thiabendazole seems to have been beneficial to this patient.19751143147
epidemiologic studies of eosinophilic meningitis in southern taiwan.a study of the epidemiologic characteristics of 125 cases of eosinophilic meningitis or meningoencephalitis, probably caused by angiostrongylus cantonensis, which occurred in southern taiwan in 1968 and 1969 revealed a close association of the disease with the rainy season. in contrast to findings in other geographic areas, most such cases in this study occurred among children. a higher attack rate was observed among aborigines than among descendants of mainland chinese. most patients had eaten ...19751155688
angiostrongylus cantonensis in the cerebrospinal fluid of an adult male patient with eosinophilic meningitis in thailand.a living, fifth-stage female angiostrongylus cantonensis 5 mm in length was discovered in the cerebrospinal fluid of a 21-year-old thai male with eosinophilic meningitis, the second such case to be recorded from thailand.19751155707
the encapsulation process in biomphalaria glabrata experimentally infected with the metastrongylid angiostrongylus cantonensis: light microscopy. 19751158554
animal model of human disease. central nervous system infection with the nematode angiostrongylus cantonenis. animal model: eosinophilic meningoencephalitis in mice infected with angiostrongylus cantonensis. 19751163634
the effect of some biological and physical factors on infection of biomphalaria glabrata with angiostrongylus cantonensis.several biological and physical factors which may influence infection of biomphalaria glabrata snails with the first stage larvae of angiostrongylus cantonensis were studied. these factors were: the size of snails, the number of first stage larvae to which snails were exposed, the age of larvae, individual exposure compared with mass exposure of snails, the length of exposure period and the effect of temperature and light. the results showed that young snails, 2 mm in diameter, became infected w ...19751189582
the suitability of several aquatic snails as intermediate hosts for angiostrongylus cantonensis.sixteen species of aquatic snails of four families were tested by quantitative technique under standardized conditions for their suitability as intermediate hosts for angiostrongylus cantonensis. these species were the planorbid snails biomphalaria glabrata, biomphalaria alexandrina, planorbis planorbis, planorbis intermixtus, bulinus truncatus, bulinus contortus, bulinus africanus, bulinus tropicus and helisoma sp.; the lymnaeid snails lymnaea natalensis, lymnaea tomentosa, lymnaea stagnalis, a ...19751189583
potential intermediate and paratenic hosts for angiostrongylus cantonensis. 19751195076
eosinophilic meningitis in thailand. clinical studies of 484 typical cases probably caused by angiostrongylus cantonensis.six hundred and forty-six patients with an eosinophilic pleocytosis were studied in thailand over a 3-year period ending in march 1968. it was possible to segregate the cases into two clinical entities, which were termed typical eosinophilic meningitis and eosinophilic myeloencephalitis respectively. the clinical and laboratory finding of 484 cases of typical eosinophilic meningitis are reported here. the latter entity was generally benign and self-limited with a case mortality ratio of less tha ...19751200257
[larvicidial activity of anthelmintics against angiostrongylus cantonensis]. 19751200975
the encapsulation process in biomphalaria glabrata experimentally infected with the metastrongylid angiostrongylus cantonensis: enzyme histochemistry. 19751206232
the first authentic record of angiostrongylus cantonensis chen, 1935 peninsular malaysia.angiostrongylus cantonensis chen, was recovered from a field rat, rattus tiomanicus from the east coast of peninsular malaysia. the parasite constitutes the first reported record occurring in this country. morphological character of the parasite are compared with the original description of a. cantonensis by chen (1935), a. cantonensis from formosa and a. malaysiensis from malaysia.19751221505
clinical observations on eosinophilic meningitis and meningoencephalitis caused by angiostrongylus cantonensis on taiwan.one hundred and twenty-five patients with eosinophilic meningitis or meningoencephalitis were studied in southern taiwan in 1968 and 1969. the majority of patients had mild to moderate disease, but several had severe manifestations. four patients died and three others had severe permanent sequelae such as blindness. young adult angiostrongylus cantonensis were recovered from nine patients, at autopsy in one, and from the cerebrospinal fluid of eight who survived. the clinical manifestations of c ...19761259085
host-parasite relationship of angiostrongylus cantonensis in lymnaea palustris. ii. histopathology. 19761269582
host-parasite relationship of angiostrongylus cantonensis in lymnaea palustris. iii. oxygen uptake of lymnaea palustris. 19761269583
characterization of monoclonal antibodies against eosinophil chemotactic factors from young adult worms of angiostrongylus cantonensis.two kinds of igg1 monoclonal antibodies against eosinophil chemotactic factors (ecfs) derived from angiostrongylus cantonensis young adult worms (ya) were established. western blot analyses demonstrated that one monoclonal antibody recognized a 16.1 kd component of ya-whole worm extract, and the other an 85 kd component. these antibodies did not show any cross reactions against several helminth antigens, as assessed by elisa. the chemotactic activity of ya-whole worm extract for guinea-pig-eosin ...19921281918
angiostrongylus cantonensis. 19921285777
[experimental study on detection of serum antibodies by immunoenzyme staining using adult angiostrongylus cantonensis frozen section].this paper reported on the results of detection of serum antibodies in rats with angiostrongylus cantonensis infection by immunoenzyme staining of adult frozen section. the positive rates of serum antibodies in rats 2 and 4 weeks after infection were 80% and 93.3%, respectively. the result of healthy control rats was negative.19921307283
seasonal intensity of angiostrongylus cantonensis in the intermediate host, laevicaulis alte.the slug, laevicaulis alte, is a vector of angiostrongylus cantonensis in the greater bombay area. the seasonal prevalence of a. cantonensis was investigated to determine the maximum intensity of the parasite in a field population occupying an area of approximately 400 m2. the maximum intensity of larvae was observed in the rainy months, june-november. investigations showed that individual l. alte could tolerate an infecting dose of 150 first-stage a. cantonensis larvae before mortalities occurr ...19921399252
in vitro effects of milbemycin oxime: mechanism of action against angiostrongylus cantonensis and dirofilaria immitis.the neuropharmacological mechanisms underlying the action of milbemycin oxime on the motility of angiostrongylus cantonensis and dirofilaria immitis were examined in vitro. in a. cantonensis, milbemycin oxime caused inhibitory effects at low concentrations of > or = 10(-9) g/ml, and paralysis was elicited at 10(-8) - 10(-6) g/ml. the paralysis was antagonized by picrotoxin and bicuculline but not by dibenamine. in addition, stimulatory effects were observed when the antibiotic was used at higher ...19921409536
[a case of eosinophilic meningitis due to angiostrongylus cantonensis].we report a case of eosinophilic meningitis caused by angiostrongylus cantonensis. this patient, a 50-year-old male, had been eating uncooked slugs for 40 years. his chief complaints on admission were headache, fever and general fatigue. neurological examination and ct findings were normal, but the csf contained increased cells, most of which were eosinophilic cells. the presence of eosinophilic cells in the csf is by itself abnormal. we therefore suspected eosinophilic meningitis and performed ...19921431377
angiostrongylus cantonensis abscess in the brain; what do we learn? 19921431977
angiostrongylus cantonensis infection in infants and young children. 19921461703
unusual manifestation of eosinophilic meningitis. 19921488715
experimental infection of yellow tree monitor (varanus bengalensis) and related species with angiostrongylus cantonensis. 19921523474
eosinophilic meningitis due to angiostrongylus cantonensis. 19921620361
characterization of monoclonal antibodies to young-adult worms of angiostrongylus cantonensis.three igg1 and one igg2a monoclonal antibodies were obtained by fusion of ns-1 cells with spleen cells of balb/c mice immunized with young-adult worm antigen of a. cantonensis. these 4 monoclonal antibodies were specific to a. cantonensis without cross-reactivity to any antigens of toxocara canis, ascaris suum, clonorchis sinensis, dirofilaria immitis, paragonimus westermani, gnathostoma spinigerum, strongyloides stercoralis and anisakis spp. detected by elisa. the affinity constants of monoclon ...19901701759
experimental infection routes of angiostrongylus cantonensis in mice.stomach intubation is the most common method used in the experimental infection of animals with angiostrongylus cantonensis. in order to compare the effectiveness of other possible transmission methods, groups of balb/c mice were given infective third-stage larvae of a. cantonensis by different routes including intraperitoneal or subcutaneous injections, and penetration of anal mucosa, vaginal mucosa, conjunctival mucosa, lacerated skin, unabraded skin, foot pad and tail skin, while stomach intu ...19911795091
angiostrongylus cantonensis abscess in the brain. 19911800649
transmission of angiostrongylus cantonensis through the giant african snail achatina fulica: an experimental study.observations on transmission of the rat lung worm, angiostrongylus cantonensis, from rats to the snail intermediate host. achatina fulica, in a vacant lot in bangkok are described. the prevalence of a. cantonensis increased with snail age until 200 days of age when it attained a plateau of 50-60%. the overall prevalence was 53%. the worm burden slowly rose with age until 200 days of age beyond which it remained relatively constant. the highest mean worm burden of 5,478 was observed in the oldest ...19911822886
snail-borne parasitic zoonoses in korea.a total of 22 snail-borne parasites causing various parasitic zoonoses in korea are listed and reviewed. all of these parasites are indigenous except heterophyes heterophyes, h. dispar and angiostrongylus cantonensis detected in patients who traveled outside of korea.19911822934
current status of food-borne parasitic zoonoses in taiwan.more than 50 species of zoonotic parasites (nematodes-18 spp., trematodes-19 spp., cestodes-10 spp., protozoa-2 spp., and arthropods-2 spp.) have been reported in taiwan. among them, angiostrongylus cantonensis, clonorchis sinensis and taenia saginata are the most important and most common food-borne parasites. angiostrongyliasis is highly endemic in southern and eastern taiwan. about 80% of patients are children below 15 years of age, mostly infected after eating achatina fulica during may and ...19911822939
eosinophilic myelomeningoencephalitis caused by angiostrongylus cantonensis: a report of three cases.three members of a family developed eosinophilic myelomeningoencephalitis following ingestion of pila snails. they were father, daughter and son and had similar clinical presentations. two days after ingestion of snails, they developed a generalized itchy maculopapular rash followed by myalgia, marked paresthesia, fever and headache. two days later there was weakness of the extremities which was progressive in severity involving the legs more than the arms. they later developed urine retention a ...19911948289
migratory effects on the body surface of angiostrongylus cantonensis from subarachnoid space to pulmonary artery in rats.juvenile worms of angiostrongylus cantonensis recovered from subarachnoid spaces and pulmonary arteries of rats, respectively, at 28 days post-infection have been compared with respect to their surface composition, antigenicity of surface proteins and morphological appearance. quantitative and qualitative differences were shown between surface proteins of these two stages of worms. one major and 6 minor proteins appeared on brain stage worm's surface as assessed by surface-labelling and sds-page ...19902075491
immunoglobulin g-dependent classical complement pathway activation in neutrophil-mediated cytotoxicity to infective larvae of angiostrongylus cantonensis.the participation of antibody and complement in cell-mediated adherence and cytotoxicity to infected larvae (l3) of angiostrongylus cantonensis was investigated in vitro. of the different cell types involved in the reaction, neutrophils were seen to have a predominant role in immune serum--dependent adherence and cytotoxicity to l3. in the presence of immune serum, cytotoxicity to l3 by neutrophils from infected rats was twice that of neutrophils from normal rats. although mononuclear cells and ...19902200361
alteration in density of eosinophils in the cerebrospinal fluid of mice infected with angiostrongylus cantonensis.the density of eosinophils in the cerebrospinal fluid (csf) and blood of male ddy mice infected with angiostrongylus cantonensis was examined on days 14, 20 and 27 post-infection (p.i.) with discontinuous percoll gradient centrifugation. normal blood eosinophils had a density of between 1.070 and 1.080 g ml-1. no significant changes in density in blood eosinophils were noted during the course of the observations. csf eosinophils began to become hypodense (defined as density less than 1.070 g ml- ...19902228429
effects of infection with angiostrongylus cantonensis on the circulating haemocyte population and the haematopoietic organ of the host snail m-line biomphalaria glabrata.the number of circulating haemocytes, the size of the haematopoietic organ, and the size of haemocyte capsules around the parasite were studied in m-line biomphalaria glabrata snails exposed to 100 or 400 first-stage larvae of angiostrongylus cantonensis. the number of haemocytes in exposed snails increased significantly at 1 day post-exposure, decreased to control value, and then increased again. the decrease in number of circulating haemocytes is probably due to the removal of cells from the c ...19902230034
a survey of ampullarium canaliculatus for natural infection of angiostrongylus cantonensis in south taiwan.ampullarium canaliculatus were collected monthly from the field in five areas in pintung county and examined for larvae of angiostrongylus cantonensis. snails from one area showed the highest positive rate (30.8%) and the highest number (31) of larvae per snail. snails were placed in four groups according to size. the positive rates in snails increased from 10.0 to 29.4% and the average number of larvae per snail increased from 11 to 40 as the size of snails increased from 1.0 to 4.0 cm height o ...19902231842
eosinophilic meningitis: cause of a chronic pain syndrome.three tourists developed eosinophilic meningitis after visiting the fijian islands. two had a severe and long lasting illness with chronic intractable pain. in one patient electrophysiological studies and mri scan of the brain were abnormal and provided evidence of both radicular and cerebral parenchymal involvement by the most likely causative agent, angiostrongylus cantonensis.19902246659
eosinophilic meningoencephalitis due to angiostrongylus cantonensis as the cause of death in captive non-human primates.fatal eosinophilic meningoencephalitis due to angiostrongylus cantonensis is reported in captive non-human primates. a howler monkey (alouatta caraya) at the audubon park and zoological gardens, new orleans, la, died 21 days after initial clinical symptoms. a white-handed gibbon (hylobates lar) died at the ardastra gardens and zoo, nassau, bahamas, 17 days after onset of symptoms. both had access to free-ranging gastropods within the zoos. these are the first reported cases of natural infection ...19902301708
eosinophilic meningitis--a case report and literature review.a case of eosinophilic meningitis in a young boy from indonesia is reported. clinically, he had a subacute meningitis with eosinophilic pleocytosis in the cerebrospinal fluid. the clinical and laboratory findings strongly suggest angiostrongylus cantonensis as the aetiologic agent although the parasite was not found. the other most likely causes in the region are also considered and the life-cycle of angiostrongylus cantonensis and the epidemiology of its infection are briefly reviewed.19902133754
[scanning electron microscopic observations on larvae and young adults of angiostrongylus cantonensis].scanning electron microscopic observations on the structure of the body surface of various larval stages and young adults of angiostrongylus cantonensis were made. the mouth opening of the first and second stage larvae closes in "y" form until well developed young adult stage. there are two rows of 6 sensory papillae each around the mouth. with development of the worm, the papillae of the outer row gradually degenerated and could hardly be seen in adult worms. a pair of amphidial pores was prese ...19902099261
eosinophilic meningitis caused by angiostrongylus cantonensis. 19902367166
eosinophilic meningitis in thailand. clinical and epidemiological characteristics of 162 patients with myeloencephalitis probably caused by gnathostoma spinigerum.the clinical and epidemiological characteristics of 162 patients with eosinophilic myeloencephalitis, believed to be caused by invasion of the central nervous system by gnathostoma spinigerum, are described. the case mortality rate was at least 12%, and probably higher. single live young adult g. spinigerum were recovered from the brains of 2 patients at autopsy and from the eye lids of 2 other living patients. the disease caused by this parasite can be distinguished from that caused by angiostr ...19902376755
differences in responses of rat- and guinea-pig-eosinophils to eosinophil chemotactic factors derived from angiostrongylus cantonensis.eosinophil chemotactic activity associated with whole worm extracts of the young adult worms (ya) and 1st stage larvae (l1) of angiostrongylus cantonensis was assessed using guinea-pig- and rat-eosinophils. both whole worm extracts were potently chemotactic to guinea-pig-eosinophils whereas only the whole worm extract of l1 was chemotactic to rat-eosinophils. gel filtration chromatography of ya-whole worm extract yielded an eosinophil chemotactic factor (ecf-ya) with an estimated molecular weigh ...19902385443
spinal sensory radiculopathy due to angiostrongylus cantonensis infection.the most common cause of eosinophilic meningitis is the rat lung worm angiostrongylus cantonensis, a parasite which is endemic in the south east asian and pacific regions. while the typical clinical presentation is that of meningitis associated with an eosinophilic pleocytosis, a 45 year old man presented with a radiculomyelopathy, associated with an eosinophilic pleocytosis and cerebrospinal fluid antibodies to a. cantonensis but without signs or symptoms of meningitis. a worm was demonstrated ...19912057434
detection of antibodies to angiostrongylus cantonensis in serum and cerebrospinal fluid of patients with eosinophilic meningitis.adult and young adult antigens of angiostrongylus cantonensis were purified by immuno-affinity chromatography and used to detect antibody in serum and cerebrospinal fluid (csf), by enzyme-linked immunosorbent assay (elisa), in cases of human eosinophilic meningitis or meningoencephalitis. the levels of igg, iga, igm and ige antibodies to a. cantonensis in these patients were higher than levels in control subjects. antibodies in patients detected against adult and young adult worm antigens of a. ...19912040566
equine neural angiostrongylosis.verminous encephalomyelitis due to angiostrongylus cantonensis larvae was diagnosed in 2 foals at necropsy. the principal clinical feature was tetraparesis, although history and neurological examination revealed progressive and multifocal neurological disease. at presentation, a tentative diagnosis of parasitic larval migration involving the central nervous system (cns), presumably due to strongylus vulgaris, was proposed. dissection of the spinal cord in one case resulted in recovery of intact ...19912025204
[intrathecal synthesis of immunoglobulins in meningoencephalitis caused by angiostrongylus cantonensis (chen, 1935)].four cases of eosinophil meningoencephalitis caused by angiostrongylus cantonensis are studied. the cytochemical study of the cerebrospinal fluid of these patients found a prevalence of eosinophils with increased ige. serum showed a variable behavior of immunoglobulins except for the increase of total ige. all patients showed igg and iga synthesis and there was igm synthesis in one patient. the percentage of intrathecal synthesis was variable and ige synthesis manifests in two trends with an equ ...19892486220
the spliced leader gene of angiostrongylus cantonensis.a 5' leader sequence has been identified on mrnas of the parasitic nematode angiostrongylus cantonensis. a 720-bp xhoi restriction fragment containing the gene encoding the leader sequence has been cloned and sequenced. it contains a 22-nt sequence identical to that of the leader sequence of caenorhabditis elegans, a consensus splice site and a putative sm antigen binding site. the gene is present as a tandem repeating unit of approximately 60 copies, and unlike c. elegans it is not associated w ...19911922196
immunodiagnosis of angiostrongyliasis with monoclonal antibodies recognizing a circulating antigen of mol. wt 91,000 from angiostrongylus cantonensis.in the analysis of excretory-secretory (es) antigens from infective third-stage larvae (l3) of angiostrongylus cantonensis, one major component of mol.wt 91,000 was not precipitated by pooled sera of patients with eosinophilic meningoencephalitis. monoclonal antibodies (mc ab) secreted from two hybridoma cell lines, established against somatic antigens of l3, recognized this molecule but with different epitope specificities indicated by an additivity index (a.i.) of 83%. the 2 mc ab (td2 and 3a5 ...19911869351
eosinophilic meningitis beyond the pacific basin: the global dispersal of a peridomestic zoonosis caused by angiostrongylus cantonensis, the nematode lungworm of rats.the principal etiologic agent of human eosinophilic meningitis, angiostrongylus cantonensis, was first detected in rats in canton, china in 1933. the first human case was detected on taiwan in 1944. epidemic outbreaks were noted on ponape (e. caroline is.) from 1944 to 1948. the disease may present as transient meningitis or a more severe disease involving the brain, spinal cord and nerve roots, with a characteristic eosinophilia of the peripheral blood and csf. since 1961 it has been known that ...19921738873
angiostrongylus cantonensis: role of eosinophils in the neurotoxic syndrome (gordon-like phenomenon).the role of eosinophils in the pathophysiology of angiostrongylus cantonensis infections was investigated in nonpermissive (guinea pig) and permissive (rat) hosts. neurological symptoms similar to the gordon phenomenon (ataxia, tremor, paralysis) together with a loss of purkinje cells in the cerebellum were observed after intracraneal injection of human eosinophil extracts or after infection with a. cantonensis, only in guinea pigs and not in rats. blood eosinophilia as well as eosinophil number ...19892721633
total and specific ige in serum and cerebrospinal fluid of rats and guinea pigs infected with angiostrongylus cantonensis.the total and specific ige response to angiostrongylus cantonensis infection was evaluated according to host permissiveness. total ige levels measured by a double antibody radioimmunoassay (ria) increased slowly in the permissive host (the rat), reaching a maximum between 4 and 8 weeks after infection. this maximum was earlier but significantly lower in the non-permissive host (the guinea pig). ige antibodies specific for adult worms or l1 or l3 larvae of a. cantonensis were measured by a radioa ...19892755934
the influence of mesocestoides corti on subsequent angiostrongylus cantonensis infections in mice.the influence of mesocestoides corti on subsequent angiostrongylus cantonensis infection in mice (c57bl/6 and balb/c) was assessed. both strains of mice infected with m. corti demonstrated a peak blood eosinophilia at around 3 weeks post-infection (p.i.). c57bl/6 and balb/c mice primarily infected with m. corti were given a. cantonensis infection 18 days later, but pre-existing m. corti infection did not affect the recovery of intracranial worms of a. cantonensis at day 21 p.i. balb/c mice with ...19921428507
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