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controlled efficacy study of the bioequivalence of strongid c and generic pyrantel tartrate in horses.the bioequivalence of strongid c and generic pyrantel tartrate was determined in a controlled study using 30 horses with naturally acquired endoparasitic infections. three horses were randomly allocated to each of ten replicates based on quantitative nematode and ascarid egg counts and fecal larvae culture results. horses within each replicate were randomly assigned to one of three treatment groups. horses in treatment group 1 received only oats; horses in treatment group 2 received generic pyra ...19958644462
[spectrum of species and incidence of endoparasites in foals and their mother mares from breeding farms with and without anthelmintic prophylaxis in upper bavaria].in this epidemiological study 37 foals and mares were included, which have been coproscopically examined in regular intervals over a period lasting up to 13 months. the animals derived from nine breeding farms. in three of these farms no anthelmintics were used before this investigation, whereas in six farms at least three years before regular prophylactic treatments with anthelmintics have been carried out. this investigation revealed no differences in the species spectrum of endoparasites as w ...19968720956
structure of the ascarosides from ascaris suum.six glycosides have been identified from the nematode ascaris suum. the glycon part of all six glycosides is alpha l-3,6-dideoxymannose, previously known as ascarylose. the major components (4 and 5) and the minor components (8 and 9) have been shown by nmr and electrospray ms to involve a mixture of two homologous aglycons: the 2, omega-1 diols of hentriacontane and tritriacontane. compounds 4 and 5 are glycosylated on only one of the hydroxy groups, while 8 and 9 are glycosylated on both. thes ...19968904841
comparison of moxidectin oral gel and ivermectin oral paste against a spectrum of internal parasites of ponies with special attention to encysted cyathostome larvae.two dosages of moxidectin oral gel were evaluated and compared to a therapeutic dose of ivermectin oral paste in the control of a spectrum of gastrointestinal parasites of ponies naturally infected in southern louisiana or mississippi. thirty-two mixed-breed ponies ranging in age from one to 21 years were used in this controlled test. eight weeks prior to the experiment, ponies grazing on contaminated pasture were moved to a paddock and fed a pelleted ration, thus reducing or eliminating the pot ...19968966989
[occurrence of parascaris equorum in foals and adult horses under different breeding conditions].autopsies and analyses of faecal samples from working horses have shown common occurrence of ascarids in foals, whereas 19.6% of adult horses have been found infected. no influence of season on epg in adult horses has been found. study based on faecal samples from stud horses has shown that 5-6-month old animals were most susceptible to the infection. 50% of foals have been found infected in spite of deworming with the use of bezimidazole compounds. it has been stated that the proper dose of an ...19968967080
natural superinfection of parascaris equorum in a stall-confined orphan horse foal.at 4 days of age, an orphan horse foal born on a pasture was placed in a parasite-free stall. it was euthanized at 205 days of age and examination revealed numerous. parascaris equorum specimens, ranging from 3.0 mm to adult size, indicating reinfections in the stall over an extended period of time. initial infection of the foal was from stages on pasture. the foal had been observed repeatedly eating its own feces and the question is posed as to whether "recycling' of p. equorum eggs several tim ...19968988563
[endoparasites of donkeys and horses kept in communal housing in upper bavaria; species spectrum and incidence].in this epidemiological study of endoparasites 37 donkeys and 23 horses were included, which were examined coproscopically in regular intervals over a 15 month period. the animals derived from ten farms, in which regular prophylactic treatments with anthelmintics had been practiced at least for two years before this investigation. this study revealed the presence of at least twelve parasite species in donkeys, eimeria leuckarti, gasterophilus intestinalis, fasciola hepatica, anoplocephala perfol ...19968999593
study on the gastrointestinal parasite fauna of ponies in northern germany.quantitative faecal and post-mortem examinations of 16 ponies, 1 to 2 1/2 years of age, originating from 3 farms in northern germany were performed in february 1995 to determine the prevalence and intensity of gastrointestinal parasites in these animals. a total of 33 species of metazoan parasites was recovered: three tapeworm species (anoplocephala perfoliata, a. magna, paranoplocephala mamillana), strongylus vulgaris, s. edentatus, small strongyles (including four triodontophorus spp., cratero ...19969060170
occurrence of gasterophilus intestinalis and some parasitic nematodes of horses in sweden.a survey was performed on the occurrence of some internal parasites in 461 horses (1-30 years old) slaughtered from october 1992 to september 1993 at the linköping abattoir in central sweden. macroscopical examination was carried out specifically for parasites of the tear ducts and conjunctival sacs of the eyes, and of selected parts of the alimentary tract and cardio-vascular system. the following parasites were found in selected parts of the large intestine: encapsulated cyathostome larvae (in ...19979257451
clinical trial of moxidectin oral gel in horses.a clinical trial carried out over 98 days was done to evaluate treatment of horses with moxidectin gel for efficacy as measured by (1) reduction in the production of parasite ova post treatment, (2) a comparison of the posttreatment parasite egg count suppression of moxidectin to ivermectin, and (3) assessment of the field safety, animal acceptance of the moxidectin formulation, and the utility of the moxidectin delivery device. one hundred and fifty standardbred horses with naturally acquired p ...19979404843
[endoparasitic fauna and incidence of species in yearling and adult horses in upper bavarian breeding farms with regular anthelmintic prophylaxis lasting for many years].in this epidemiological study 127 horses from five breeding farms in upper bavaria were included. the horses were coproscopically examined in intervals of four weeks over a 16-month period. since 1992 in all farms regular prophylactic treatments with anthelmintics have been carried out. in 127 horses at least five species were established, such as parascaris equorum, anoplocephala perfoliata, gasterophilus intestinalis and small strongyles, whose third stage larvae were characterized by eight or ...19979441048
parasites of stomach and small intestine of 70 horses slaughtered in the netherlands.the prevalence of metazoan parasites in the stomach and small intestine was investigated in 70 horses slaughtered in the period february 1994-july 1994. most horses were young (1.5-3 years) and in good condition. trichostrongylus axei was the most prevalent parasite species in the stomach (51.4%), followed by gasterophilus intestinalis (41.4%) and habronema spp. (4.3%). in the small intestine, parascaris equorum (28.6%) and paranoplocephala mamillana (1.4%) were found. the mean worm burden of t. ...19989477534
expression of a single dimeric membrane-bound acetylcholinesterase in parascaris equorum.a single form of cholinesterase was detected in the parasitic nematode parascaris equorum and purified from a low-salt triton x-100 extract of whole animals by affinity chromatography on an edrophonium-sepharose matrix. based on gel-filtration chromatography, sedimentation analysis and sds-page, such a cholinesterase is an amphiphilic globular (g2) dimer (125-129 kda, 6.1 s). it includes some hydrophobic domain other than phosphatidylinositol, which gives autoaggregation, detergent interaction a ...19979488877
single-strand conformation polymorphism (sscp)-based mutation scanning approaches to fingerprint sequence variation in ribosomal dna of ascaridoid nematodes.in this study, we assessed single-strand conformation polymorphism (sscp)-based approaches for their capacity to fingerprint sequence variation in ribosomal dna (rdna) of ascaridoid nematodes of veterinary and/or human health significance. the second internal transcribed spacer region (its-2) of rdna was utilised as the target region because it is known to provide species-specific markers for this group of parasites. its-2 was amplified by pcr from genomic dna derived from individual parasites a ...19989694283
efficacy of a 2 per cent moxidectin gel against gastrointestinal parasites of ponies.the efficacy of moxidectin was evaluated in young ponies naturally infected with gastrointestinal parasites. eight animals were treated orally with moxidectin at 0.4 mg/kg bodyweight and eight received only the vehicle. they were all necropsied two weeks later. faecal samples were examined daily for egg counts and larval cultures. parasites were recovered from total faecal samples collected daily and from the gastrointestinal tracts at necropsy. moxidectin reduced the strongyle egg counts by > 9 ...19989854319
comparative efficacy evaluation of moxidectin gel and ivermectin paste against internal parasites of equines in brazil.a total of 24 male and female equines of mixed breed, 10-20 months of age and naturally infected with internal parasites was utilized in a controlled test to evaluate the efficacy of a moxidectin 2% gel formulation at the dosage of 0.4 mg moxidectin per kg of live weight and an ivermectin 1.87% commercial paste formulation at the dosage 0.2 mg ivermectin per kg applied orally. animals were allocated into three groups of eight horses each based on pre-treatment eggs per gram (epg) counts and trea ...19989877068
transglutaminase activity in equine strongyles and its potential role in growth and development.transglutaminases (e.c. 2.3.3.13) are a family of ca(2+)-dependent enzymes that stabilize protein structure by catalyzing the formation of isopeptide bonds. a novel form of transglutaminase has been identified and characterized that seem to play an important role in growth, development, and molting in adult and larval stages of filarial nematodes. the aim of this study was to identify the ubiquitous nature of this enzyme in other nematodes and to measure its significance to larval growth, moltin ...199910416187
sulfidoleukotriene generation from peripheral blood leukocytes of horses affected with insect bite dermal hypersensitivity.sulfidoleukotrienes (slt) generated in vitro after incubation of equine peripheral blood leukocytes (pbl) with different inducing agents were determined in 18 healthy and 16 insect bite dermal hypersensitivity (idh)-affected horses. pbl from these 32 horses were stimulated with concanavalin a, parascaris equorum, culicoides nubeculosus and simulium extracts, and with a six-grass mix. the cells of all but four horses generated slt after incubation with concanavalin a; these four horses did also n ...199910587309
prevalence of selected species of internal parasites in equids at necropsy in central kentucky (1995-1999).a survey to determine current prevalence of several species of endoparasites in equids (n=350) at necropsy was conducted at the livestock disease diagnostic center in central kentucky (1995-1999). thelazia lacrymalis were found in 42% of the 1- to 4-year olds (n=132), which was the only age group examined for these parasites. five- to 30-year olds (n=157), examined for onchocerca spp. worms/lesions, had a prevalence of 24%. in > or =1-year olds (n=324), the infection rate for gasterophilus intes ...200010936545
transmission of endoparasites in horse foals born on the same pasture on a farm in central kentucky (1996-1999).research carried out during the last 4 years (1996-1999) of an 11-year study of the prevalence of internal parasites naturally transmitted to horse foals born on the same pasture on a farm in central kentucky is presented here. horses in this herd were not treated with any antiparasitic compound for over 20 years except for a replacement stallion in 1994. a total of 22 species, including 12 species of small strongyles, were recovered in the 4-year period. transmission patterns of all species (n= ...200111358626
re-evaluation of ivermectin efficacy against equine gastrointestinal parasites.two trials were conducted to confirm the efficacy of ivermectin paste against endoparasites of horses. in these trials, 20 ponies were treated with ivermectin oral paste at 200 mcg x kg body weight once on day 0, and 20 ponies served as unmedicated controls. the animals carried naturally acquired parasite infections as confirmed by pretrial fecal examination. the animals were necropsied for worm recovery on days 14, 15 or 16. parasites recovered were identified to species. horses treated with iv ...200111423189
seasonal transmission of gastrointestinal parasites of equids in southern louisiana.parasite-naive pony foals were used as sentinels to monitor transmission of gastrointestinal parasites of equids in louisiana during 4 seasons of the year. two annual periods were studied, 1988-1989 and 1992-1993. two or 3 foals each season were turned out to graze a contaminated pasture along with resident parasitized mares and their foals. after a grazing period of 8 wk, sentinel ponies were held in a parasite-free box stall for a period of 6 wk to allow parasites to develop, thus enhancing th ...200111780824
apparent resistance of parascaris equorum to macrocylic lactones. 200211924584
cecal rupture by anoplocephala perfoliata infection in a thoroughbred horse in seoul race park, south korea.a 7-year-old thoroughbred horse was admitted to the equine hospital, korea racing association with signs of colic. based on the size of impactions, the clinical signs, the results of abdominal paracentesis and medical treatment, the prognosis was poor. the horse died 3 hours later following hopeless discharge. at necropsy, the caecum and large colon were fully filled with fecal contents and there was a rupture (10 cm in dia) in the latero- ventral caecum. the mucosa of the ileo-caecal and caeco- ...200112441687
ascarid nematodes in domestic and wild terrestrial mammals.the biology of the ascarid nematodes has been discussed in the context of their important economic role in farm animals, pet animals and zoo animals with special attention to carnivores and primates. in farm animals, infection with the most common roundworm of horses (parascaris equorum) and swine (ascaris suum) depend on many factors such as environmental conditions (larval development in the egg and egg survival), age of the host, breed, husbandry system, hygiene and treatment schedule. the mo ...200212512563
gastrointestinal helminths of ponies in louisiana: a comparison of species currently prevalent with those present 20 years ago.a survey in louisiana of gastrointestinal helminths recovered at necropsy from 117 ponies with minimal exposure to anthelmintics between 1989 and 2000 is compared with a survey conducted 20 yr earlier in the same region. an objective of this study was to determine whether species diversity has been affected by the advent and use of the macrocyclic lactone (ml) parasiticides and by the increased anthelmintic pressure on the helminth species infecting the general equine population. twenty-six cyat ...200212537106
identification of foals infected with parascaris equorum apparently resistant to ivermectin.during september 2002, routine fecal examinations performed on 16 thoroughbred foals residing on a farm outside toronto, ontario, canada, revealed low to moderate numbers of parascaris equorum eggs in feces from 9 of the 16. all foals were then treated with ivermectin at a dose of 220 to 280 microg/kg (100 to 127 microg/lb), p.o., and fecal egg counts were repeated 12 days later. fecal p. equorum egg counts increased between the first and second fecal examination in 7 foals, were unchanged in 1, ...200312930086
[protein inclusions of the egg of parascaris equorum]. 195313094844
purification and analyses of the specificity of two putative diagnostic antigens for larval cyathostomin infection in horses.cyathostomins are important equine gastrointestinal parasites. mass emergence of mucosal stage larvae causes a potentially fatal colitis. mucosal stages are undetectable non-invasively. an assay that would estimate mucosal larval stage infection would greatly assist in treatment, control and prognosis. previously, we identified two putative diagnostic antigens (20 and 25 kda) in somatic larval preparations. here, we describe their purification and antigen-specific igg(t) responses to them. weste ...200313129671
the chromosomal cycle in parascaris equorum (ascaris megalocephala); oogenesis and diminution. 195413172849
[protein inclusions in the oocyte of parascaris equorum]. 195413200515
[chemical structure of ascarylic alcohol isolated from parascaris equorum]. 195713426704
[ultrastructure of the protoplasm of parascaris equorum oocytes]. 195813535249
[electron microscopic investigation on the muscle cells of parascaris equorum goeze]. 195913648714
[on experimental microascaridiosis. note i. behavior of infestation by larvae of parascaris equorum]. 196013700828
demonstration of canonic gonial mitosis and meiosis in parascaris equorum.it is shown that, contrary to what has been held, separate canonic chromosomes, without fusion into a chromatin mass, occur in the meiotic prophase of parascaris equorum. in mitosis no club-shaped chromosome ends are visible. these results, obtained with a modified fixation procedure, which is described, have been checked by supravital observation.196013750290
[properties of protein reserve in the parascaris equorum oocyte]. 195414364945
[desoxyribonucleic acid content of the gametes of parascaris equorum goeze]. 195514390852
[ultrastructure of the cellular membrane of the intestine of the horse ascaris (parascaris equorum goetze)]. 196214452659
prevalence of parasite eggs (strongyloides westeri, parascaris equorum, and strongyles) and oocysts (emeria leuckarti) in the feces of thoroughbred foals on 14 farms in central kentucky in 2003.prevalence of internal parasites was determined by fecal examination for eggs and oocysts in thoroughbred foals in central kentucky in 2003. fecal samples were examined from 733 foals on 14 farms. this included 70 trips to the farms and a total of 2,346 fecal samplings. monthly collection of fecal samples was begun for four farms in february, six in march, three in april, and one farm in may. termination of the study for all farms was the end of july. a criterion was that the foals be at least 1 ...200414760526
[cytochemical analysis of certain phenomena of reactivation of ribonucleoproteins; parascaris equorum ovum following fertilization]. 195114886040
occurrence of gastrointestinal parasites in horses in metropolitan perth, western australia.to assess the occurrence of gastrointestinal parasites in horses in perth. to apply polymerase chain reaction (pcr) for the identification of some species of encysted larval cyathostomes.200415088968
gastrointestinal impaction by parascaris equorum in a thoroughbred foal in jeju, korea.a weanling thoroughbred foal was admitted to equine hospital, korea racing association with signs of colic. on admission the foal was sweating profusely, appeared anxious and exhibiting signs suggestive of abdominal pain. clinical examination revealed: tachycardia (90 beats/min), tachypnea (50 breaths/min) and congested and slightly cyanotic mucous membranes. no intestinal sounds were auscultated in all 4 abdominal quadrants. rectal palpation identified concurrent cecum and large colon impaction ...200415192347
[results of parasitological examinations of faecal samples from horses, ruminants, pigs, dogs, cats, hedgehogs and rabbits between 1998 and 2002].the results of coproscopical examinations in horses, ruminants, pigs, dogs, cats, hedgehogs and rabbits between 1998 and 2002 are presented. in 4399 samples from horses 37.4% stages of strongylids, 1.4% anoplocephalids, 1.3% strongyloides westeri, 0.9% parascaris equorum, 0.04% oxyuris equi, 0.04% eimeria sp. and 0.04% fasciola hepatica were found. in 998 samples of cattle 22.1% stages of strongylids, 11.2% of eimeria spp., 3.5% of cryptosporidium, 2.9% of moniezia spp., 1.3% of trichuris spp., ...200415287577
analysis of the strongylid nematodes (nematoda: strongylidae) community after deworming of brood horses in ukraine.communities of intestinal helminths in horses are commonly studied post mortem. the study objectives were here to examine the species composition of the strongylid community in brood horses in ukraine after deworming with an aversectin drug univerm. the site distribution of the strongylid species was analysed according to dynamics of their expulsion in faeces. forty-four horses of different ages from poltavska oblast (22 horses), kyivska oblast (17 horses) and sumska oblast (5 horses) of ukraine ...200515979240
prescription-only anthelmintics--a questionnaire survey of strategies for surveillance and control of equine strongyles in denmark.in 1999, legislation in denmark made anthelmintic drugs available only by prescription, and prohibited their use for routine, prophylactic treatment. a questionnaire survey was conducted in 2004 to determine current strategies for surveillance and control of equine strongyles used in danish equine veterinary practices. eighty-seven of 170 (51.2%) registered equine veterinary practices responded. ninety seven percent of the respondents used faecal egg counts for diagnosis and surveillance, and 41 ...200616309841
field studies on endoparasites of thoroughbred foals on seven farms in central kentucky in 2004.fecal samples (n=1,584) for a parasite study were collected from thoroughbred foals (n=349), 28 to 330 days old, on seven farms in central kentucky during 49 monthly trips from may to october, november, or december 2004. the main purpose was to determine possible drug resistance of ascarids, also of strongyles, to ivermectin (ivm) and other commercially available compounds [fenbendazole, moxidectin (mox), oxibendazole (obz), and pyrantel pamoate]. in addition, interest was on prevalence of foal ...200616385405
prevalence of large endoparasites at necropsy in horses infected with population b small strongyles in a herd established in kentucky in 1966.two closed horse herds (old lot 4 and field 24), infected since 1966 with population b small strongyles resistant to thiabendazole (tbz) and phenothiazine (ptz), were terminated in february, march, and may, 2005. at necropsy, only the large endoparasites were identified and counted. the number of horses on pasture was 14 (239 days of age to 23 years old) for old lot 4 and two (3 to 20 years old) for field 24. the time of the last antiparasitic treatment, relative to the year (2005) of necropsy, ...200616508764
ivermectin resistance in parascaris equorum. 200616632539
gastrointestinal parasitic worms in equines in the paraíba valley, state of são paulo, brazil.over a period of 12 years, from 1988 to 2000, a total of 20 individual equines (16 horses and 4 mules) were selected at random, from 10 municipalities in the paraíba valley, in the state of são paulo, brazil, and then subjected to necropsy for collection of gastrointestinal worms. individual samples of 10% of the intestinal contents were also taken for counting and identifying the species present, and to establish the prevalence of worms in equine species in the paraíba valley. in the sample con ...200616687215
effects of low and high temperatures on viability of parascaris equorum eggs suspended in water.microcentrifuge tubes containing 5000 eggs of parascaris equorum suspended in water were frozen at -5, -10, -15, -20, and -80 degrees c for 1-168 h and then thawed at a room temperature. other samples of p. equorum eggs suspended in water were inserted into wells in the heated metal block of a thermal dna cycler. block temperatures were set at 5 degrees c incremental temperatures from 40 to 100 degrees c. at each temperature setting microcentrifuge tubes containing p. equorum eggs were removed 1 ...200616876952
macrocyclic lactone-resistant parascaris equorum on stud farms in canada and effectiveness of fenbendazole and pyrantel pamoate.the aims of studies in 2002 and 2003 on three farms with 76 foals naturally infected with parascaris equorum were to (i) identify if the nematode was resistant to ivermectin and moxidectin, and (ii) confirm the effectiveness of fenbendazole and pyrantel pamoate for the parasite. twelve clinical trials, each with a fecal egg count reduction test, were conducted on two thoroughbred and one standardbred farms in southwestern ontario, canada. in each trial, parascaris eggs/g feces were estimated for ...200716962243
parasite field study in central kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically.foals (79), born in 2004 on three thoroughbred horse farms (c, m, and s) in central kentucky, were fed pyrantel tartrate daily, beginning at about 3 months of age. in addition, other parasiticides [fenbendazole (fbz), ivermectin (ivm) alone or with praziquantel (praz), oxibendazole (obz), pyrantel pamoate (prt), and moxidectin (mox)] were given periodically. all treatments were administered by farm personnel. over a 14-month period, from may 2004 to july 2005, collections (n=989) of feces were m ...200717013652
cases of reduced cyathostomin egg-reappearance period and failure of parascaris equorum egg count reduction following ivermectin treatment as well as survey on pyrantel efficacy on german horse farms.in 2003 and 2004, on a total of 63 different german horse farms, a survey using the faecal egg count reduction (fecr) test was performed to investigate the efficacy of ivermectin (ivm, ivomec) and pyrantel (pyr, banminth) treatment against gastro-intestinal nematodes in a total of 767 horses. ivm treatment resulted in 100% reduction of the cyathostomin egg production 14 and 21 days post-treatment (d.p.t.) on 37 farms. on the remaining five farms, the mean faecal egg count reduction ranged betwee ...200717112667
acute small intestinal obstruction associated with parascaris equorum infection in young horses: 25 cases (1985-2004).to retrospectively evaluate the medical and surgical records of horses with acute small intestinal obstructions associated with parascaris equorum infection; to describe the gastrointestinal lesions; and to determine the outcome of cases with such lesions.200617151735
apparent ivermectin resistance of parascaris equorum in foals in denmark. 200717400903
occurrence of roundworm (parascaris equorum) in horses from small farms based on necropsy.the objective of this study was to evaluate the level of roundworm infection in working horses slaughtered for meat. in these horses anthelmintics had not been used.200617432627
parascaris equorum in foals and in their environment on a swedish stud farm, with notes on treatment failure of ivermectin.environmental contamination and the egg excretion pattern of the ascarid parascaris equorum (nematoda) was investigated in relation to anthelmintic treatment on a swedish stud farm. faecal samples from 15 foals, dewormed every 8th-week with a paste formulation of ivermectin at the standard dose rate of 0.2 mg/kg bodyweight, were collected at five sampling occasions between august and november 2006. in addition, soil samples were obtained from four paddocks used by these foals in november 2006. t ...200818077096
equine parascarosis under the tropical weather conditions of ethiopia: a coprological and postmortem study.a cross-sectional coprological survey in the regions of ada, akaki, bereh and boset, and a retrospective postmortem investigation were conducted to study the epidemiology of parascaris equorum in donkeys and horses in ethiopia. faecal samples from 803 working donkeys and 402 horses were collected, and the numbers of worms recovered from 112 donkeys examined postmortem between 1995 and 2004 were analysed. there was a high prevalence of infection and faecal egg output of p equorum in both donkeys ...200818263917
parascaris equorum resistance to moxidectin? 200818359937
parascaris equorum resistance to moxidectin? 200818408204
evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (parascaris equorum) in field studies on five farms in central kentucky in 2007.horse foals on five farms in central kentucky were used in field studies in 2007 evaluating activity of paste formulations of four compounds (fenbendazole-fbz, ivermectin-ivm, oxibendazole-obz, and pyrantel pamoate-prt) against internal parasites with emphasis on ascarids (parascaris equorum). it has been well established the last few years that there is widespread resistance of p. equorum to ivermectin. the main purpose of the present research was to obtain current data on ascaridicidal activit ...200818470536
anthelmintic resistance in cyathostomins of brood horses in ukraine and influence of anthelmintic treatments on strongylid community structure.in 2004-2006, 322 brood horses from 11 horse farms were examined using the faecal egg count reduction test (fecrt) to determine the presence and distribution of anthelmintic resistance in strongylids in ukraine. the anthelmintic drugs "albendazole-7.5" (7.5mg of albenazole, ukraine) at a dose of 5mg per kg body weight and "univerm" (0.2% aversectin c, russia) at a dose of 0.5mg per kg body weight were used. seventy-one horses from six farms were examined in vivo to investigate the influence of a ...200818485600
intestinal parasitism in the animals of the zoological garden "peña escrita" (almuñecar, spain).gastrointestinal parasites cause serious diarrhoea in captive animals. therefore, we have undertaken this study to establish programmes to prevent, control, and treat intestinal parasitism in the animals of the zoological garden "peña escrita" of almuñecar (granada). an annual survey was conduced to estimate the occurrence of gastrointestinal parasites and the seasonality of this parasitism. between june 2006 and may 2007, 432 samples were collected from primates, carnivores, perissoodactyla, ar ...200818639383
probable reason why small strongyle epg counts are returning "early" after ivermectin treatment of horses on a farm in central kentucky.critical tests were carried out in 2008 in four yearling horses (h-2, h-4, h-10, and h-11) born and raised together on a farm (mc) in central kentucky. these horses were treated intraorally with ivermectin paste at the dose rate of 200 microg/kg. the main interest was to try and determine more precisely, from posttreatment (pt) worm count data, the current activity of ivermectin against small strongyles in a horse herd. these horses had been treated repeatedly with this compound and counts of sm ...200918931857
field effectiveness of pyrantel and failure of parascaris equorum egg count reduction following ivermectin treatment in italian horse farms.a study was carried out to assess the field efficacy of ivermectin (ivm) and pyrantel pamoate (pyr) against parascaris equorum. seventy-three foals (3-18 months old) from 5 stud farms, not treated with anthelmintics in the previous 10 weeks and with individual faecal egg counts (fec) >200, were included in the study. for each stud farm, 5-7 foals were included in the ivm-treatment group (ivm 0.2%, 200 mcg/kg body weight) or in the pyr-treatment group (pyr 38%, 13.2mg/kg body weight) and 3 were u ...200919201100
gastrointestinal parasites of working donkeys of ethiopia.the general prevalence and population composition of gastrointestinal and pulmonary helminths of working donkeys were studied. for the purpose 2935 working donkeys were coprologically examined for nematode and cestode, and 215 donkeys for trematode infections. seven donkeys that died due to various health problems or were euthanased on a welfare ground were necropsied and the parasites were recovered and identified to the species level. the study was conducted during the periods 1996-1999.coprol ...201019548106
parasitism and colic.equids are hosts to dozens of species of internal parasites that infect no other domestic animals. virtually all horses, especially those exposed to pasture, experience some level of parasitism continuously. despite pathologic evidence of parasitic damage in various organs and tissues, few parasitisms are manifested systemically in well-managed horses. contrary to conventional wisdom, only three common parasitisms of horses are likely to be manifested as colic: strongylus vulgaris, parascaris eq ...200919580936
silvopastoralism and autochthonous equine livestock: analysis of the infection by endoparasites.two groups of autochthonous pura raza galega (prg) horses, one comprising 483 animals under a silvopasturing regime, and the other comprising 72 prg horses managed in farms, were used to analyse the effect of silvopasture on infection by endoparasites. results were considered according to the age and the sex of the horses. faecal samples were individually collected from each animal and analysed by the coprological flotation, sedimentation and migration techniques. coprocultures were also done to ...200919632049
viability of rhodococcus equi and parascaris equorum eggs exposed to high temperatures.there is great concern about the potential pathogen contamination of horse manure compost spread in the same fields horses graze in. to ensure that pathogen destruction occurs, temperatures need to be sufficiently high during composting. here, we investigated the survival rate of two marker organisms, rhodococcus equi and parascaris equorum eggs, exposed to temperatures potentially encountered during horse manure composting. our results show that the time required to achieve a 1 log10 reduction ...201019727941
diagnosis and control of anthelmintic-resistant parascaris equorum.abstract : since 2002, macrocyclic lactone resistance has been reported in populations of parascaris equorum from several countries. it is apparent that macrocyclic lactone resistance developed in response to exclusive and/or excessively frequent use of ivermectin or moxidectin in foals during the first year of life. the development of anthelmintic resistance was virtually inevitable, given certain biological features of parascaris and unique pharmacologic characteristics of the macrocyclic lact ...200919778469
anthelmintic efficacy on parascaris equorum in foals on swedish studs.in the last few years stud farms have experienced increasing problems with parascaris equorum infections in foals despite intensive deworming programs. this has led to the question as to whether the anthelmintic drugs used against this parasite are failing. this study aimed to investigate the efficacy of ivermectin, fenbendazole and pyrantel on the faecal output of ascarid eggs of foals.200919930608
[parasitological prevalence of cart-horses in curitiba, paraná].the carthorses are used as an alternative for people of low income for collecting recyclable material. however, these horses are managed without proper assistance, suffering several problems, among them the parasites. in this study we used 41 animals, their body condition score and other parameters were analyzed and parasite egg count was performed from fecal samples. it was determined the absence of eggs on 12% and parasite infection in 88%. strongylids were found in all contaminated animals, o ...200820059842
endoparasite control management on horse farms--lessons from worm prevalence and questionnaire data.increasing prevalence of anthelmintic resistance in equine nematodes calls for a reexamination of current parasite control programmes to identify factors influencing control efficacy and development of resistance.201020121919
efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of parascaris equorum in horses.the expanding prevalence of parascaris equorum populations that are resistant to macrocyclic lactone (ml) anthelmintics makes it desirable to identify dewormers which remain effective. the objective was to evaluate the efficacy of pyrantel pamoate in 14 suckling foals that had been infected orally with approximately 600 larvated eggs of a p. equorum isolate selected for ml resistance (ml-r). seventy days after inoculation, foals were weaned, housed individually, and fecal samples were examined f ...201020307936
biodiversity and distribution of helminths and protozoa in naturally infected horses from the biosphere reserve la sierra madre de chiapas", méxico.a cross sectional survey was performed to identify gastrointestinal helminths and protozoans in naturally infected horses from the biosphere reserve known as "la sierra madre de chiapas", mexico (el triunfo and la sepultura). during a three-year survey, fecal samples from 90 horses and parasites from 2 necropsied animals were collected. five families from the nematoda class: ascaridae, kathlanidae, oxyuridae, strongylidae and trichostrongylidae were found, whereas, only one family from the class ...201020307938
[a survey on anthelmintic resistance in strongyles to ivermectin and pyrantel and macrocyclic lactone-resistance in parascaris equorum.]this survey was carried out on a horse farm in order to acquire recent data on macrocyclic lactone-resistant parascaris equorum which had been previously detected on this farm and to determine efficacies of ivermectin and pyrantel against strongyles in order to determine whether a resistance problem also exists in these parasites. in the first part of the study, abamectin was given to horses infected with p. equorum. in 11 out of 12 horses, zero efficacy (0%) was seen against p. equorum. subsequ ...201020340086
determination of ivermectin efficacy against cyathostomins and parascaris equorum on horse farms using selective therapy.ivermectin resistance has recently been described in parascaris equorum and there have been reports from several countries of a shortened egg reappearance period (erp) following ivermectin treatment for cyathostomins. this study was aimed at determining the efficacy of ivermectin in treating cyathostomins and p. equorum in danish horses. a total of 196 animals were selected from 52 farms, all of which were using a selective anthelmintic treatment strategy. erp was investigated with weekly sample ...201120385508
are macrocyclic lactones useful drugs for the treatment of parascaris equorum infections in foals?a study was carried out to assess the field efficacy of moxidectin (mox) against parascaris equorum in foals. a total of 70 foals from 2 italian thoroughbred (farms 1 and 2) stud farms and one trotter stud farm (farm 3), aged 3-5 months and with faecal egg counts (fec) f>or=300 eggs per gram (epg) were included in the study. on each farm, foals were divided into 2 groups (of 10, 8 and 10 foals, respectively) and treated with either moxidectin (mox, 400 mcg/kg b.w.) or ivermectin (ivm, 200 mcg/kg ...201020471177
coprological prevalence and intensity of helminth infection in working horses in lesotho.this study aimed to (1) estimate infection prevalence of strongyle, oxyuris equi and parascaris equorum species and the intensity of infection with strongyles in working horses in lowland lesotho and (2) investigate associations between infection and horse age, sex and owner-reported use of anthelmintics. in a cross-sectional survey, fresh faecal samples were obtained from 305 randomly selected horses and worm egg counts performed using a validated field laboratory kit. details of anthelmintic u ...201020574819
prevalence of gastrointestinal parasites in working horses.fecal samples for detection of gastrointestinal parasites were collected from 221 working horses from september 2002 to may 2003 from 14 villages in urmia, north west of iran. fecal samples of 46 horses (20.8%) were negative for parasite eggs or oocysts. one hundred and seventy five positive horses (48.9%) were infected with a single parasite type and 49 (22.2%) and 18 (8.1%) of horses had multiple infections with two and three parasites, respectively. the highest prevalence and intensity rate b ...201020731187
analysis of multiyear studies in horses in kentucky to ascertain whether counts of eggs and larvae per gram of feces are reliable indicators of numbers of strongyles and ascarids present.increasing levels of anthelmintic resistance in equine nematodes have led to recommendations of more sustainable anthelmintic treatment protocols with emphasis on parasite surveillance and diagnosis, rather than prophylactic calendar-based treatments. this requires knowledge of the diagnostic test performance of techniques for counts of eggs per gram of feces (epg) as well as methods for culturing, counting and identifying third stage (l(3)) strongyle larvae per gram of feces (lpg). for horses, ...201020850927
4d chromatin dynamics in cycling cells: theodor boveri's hypotheses revisited.this live cell study of chromatin dynamics in four dimensions (space and time) in cycling human cells provides direct evidence for three hypotheses first proposed by theodor boveri in seminal studies of fixed blastomeres from parascaris equorum embryos: (i) chromosome territory (ct) arrangements are stably maintained during interphase. (ii) chromosome proximity patterns change profoundly during prometaphase. (iii) similar ct proximity patterns in pairs of daughter nuclei reflect symmetrical chro ...201021327076
parascaris and cyathostome nematodes in foals: parasite in transit or real infection?faecal egg counts were performed in 187 foals of a large polish stud farm between february and september 2007. eggs of parascaris equorum were present in faeces of 7% and those of cyathostomins in 13% of the foals aged less than 194 days. information dealing with age of foals and/or efficiency of ivermectin treatment as well as the nematode parasite prepatent periods, it can be conducted that most of the infections recorded on the basis of faecal egg counts were false-infections in animals up to ...201021370752
further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid parascaris equorum in horse foals on eight farms in central kentucky (2009-2010).the activity of three anthelmintics (fenbendazole-fbz; oxibendazole-obz; and pyrantel pamoate-prt) was ascertained against the ascarid parascaris equorum in horse foals on eight farms in central kentucky (2009-2010) in field tests. a total of 316 foals were treated, and 168 (53.2%) were passing ascarid eggs on the day of treatment. evaluation of drug efficacy was determined qualitatively by comparing the number of foals passing ascarid eggs in their feces before and after treatment. the main pur ...201121499750
impaired efficacy of ivermectin against parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in finland.in order to assess the resistance situation against macrocyclic lactones in parascaris equorum and against tetrahydropyrimidine derivatives in strongyles in finnish trotter horses, 112 foals on 18 farms, mostly 1 year old, were examined for these parasites with a modified mcmaster faecal flotation method. p. equorum positive foals (n=24) were given ivermectin orally at a dose of 200++g/kg b.w., while strongyle positive but p. equorum negative foals (n=38) received pyrantel embonate orally at a d ...201121689886
field study on the efficacy of an oral 2% ivermectin formulation in horses.twenty horses naturally infected with nematodes were included in a blind, controlled field study on efficacy and safety of an oral 2% ivermectin formulation at a dose of 0.2 mg.kg(-1). horses were divided into treated and non-treated (control) groups with ten animals each based on preliminary counts of eggs per gram of feces (epg). stool samples were collected after treatment for identification of nematode species. clinical evaluations and epg counts were performed on days 0, +5, +14 and +19. ni ...201121722495
anthelmintic resistance in non-strongylid parasites of horses.since 2002, selected populations of parascaris equorum in several countries have been reported to survive treatment with macrocyclic lactone (m/l) anthelmintics. clinical treatment failures are characterized by negligible fecal egg count reduction, but m/l resistance has been confirmed in ascarids by controlled efficacy testing. resistance was selected by current parasite control practices for foals, which often include exclusive and excessively frequent use of m/l dewormers, thereby minimizing ...201122078748
anthelmintic resistance in equine parasites - detection, potential clinical relevance and implications for control.during the past two decades anthelmintic resistance in equine parasites has been found in the group of small strongyle species (cyathostomins) and in the ascarid species parascaris equorum. the ubiquitous nature and possible severe consequences of disease with these nematodes make them the prime targets of current worm control programmes. traditional control strategies mainly rely on the strategic application of anthelmintics, currently represented by three major drug classes: benzimidazoles (bz ...201122100141
[Parasites observed in a zebra in izmir].This work consists of a case report on a zebra presented to our institute for the determination of the cause of death. The animal was subjected to necropsy before it was presented to our institute. During examination, ascarids in the intestines and myasis agents in the stomach were observed. The parasites seen in the stomach and the intestines were identified according to the identification key and afterwards counted. In this work, the ascarids were identified as Parascar ...201122198919
[effect of distribution of eggs of strongyles and parascaris equorum in faecal samples of horses on detection with a combined sedimentation-flotation method].results of parasitological examination of faecal aliquots may vary between diagnostic laboratories. to examine whether inhomogeneous distribution of worm eggs in faecal samples is responsible for this observation, horse faeces provided for routine diagnosis of helminth infection were examined. distribution of worm eggs was assessed by examining aliquots taken from different locations of the faecal sample by a combined sedimentation-flotation method (ksfv). in addition, it was tested, whether the ...201222331287
prevalence of parascaris equorum infection in foals on french stud farms and first report of ivermectin-resistant p. equorum populations in france. 201222494940
the effects of windrow composting on the viability of parascaris equorum eggs.parascaris equorum generally infects horses less than 18 months old and its pathological effects can be severe. infection occurs when larvated eggs, present in pastures, paddocks, stalls, and on feeding and watering equipment are ingested. the purpose of this study was to examine the effects of windrow composting on the viability of p. equorum eggs at a cooperating central kentucky horse farm. three grams of feces containing 2216 p. equorum eggs per gram were sealed in filter bag sentinel chambe ...201323000290
prevalence, intensity and seasonality of gastrointestinal parasites in abattoir horses in germany.prevalence and intensity of gastrointestinal parasites were studied through a longitudinal survey in 400 horses over a 17-month period in an abattoir in germany. three hundred and ten horses (77.5 %) were demonstrated harbouring endoparasites either by direct recovery of parasites from the digestive tract and/or in terms of faecal egg counts (strongyles). the following parasites were found (percentage prevalence, range of counts): gasterophilus intestinalis larvae (2.25 %, 1-154), gasterophilus ...201323052780
population genetics of parascaris equorum based on dna fingerprinting.the large roundworm of horses, parascaris equorum is considered ubiquitous in breeding operations, and is regarded as a most important helminth pathogen of foals. over the past decade, this parasite has been reported increasingly resistant to anthelmintic drugs worldwide. this paper reports analysis of the population genetic structure of p. equorum. adult parasites (n=194) collected from sweden, norway, iceland, germany, brazil and the usa were investigated by amplified restriction fragment leng ...201323168211
recent advances in diagnosing pathogenic equine gastrointestinal helminths: the challenge of prepatent detection.parasites infecting horses are ubiquitous and clinically important across the world. the major parasitic threats to equine health are cyathostomins, parascaris equorum, anoplocephala perfoliata, and strongylus vulgaris. increasing levels of anthelmintic resistance reported world wide in equine parasites have led to recommendations of constructing sustainable parasite control programmes based on systematic surveillance of parasite levels. regulations at the european union level now make anthelmin ...201323199789
duplex quantitative real-time pcr assay for the detection and discrimination of the eggs of toxocara canis and toxocara cati (nematoda, ascaridoidea) in soil and fecal samples.toxocarosis is a zoonotic disease caused by toxocara canis (t. canis) and/or toxocara cati (t. cati), two worldwide distributed roundworms which are parasites of canids and felids, respectively. infections of humans occur through ingestion of embryonated eggs of t. canis or t. cati, when playing with soils contaminated with dogs or cats feces. accordingly, the assessment of potential contamination of these areas with these roundworms eggs is paramount.201223216873
helminth egg excretion with regard to age, gender and management practices on uk thoroughbred studs.few studies have described the combined effect of age, gender, management and control programmes on helminth prevalence and egg shedding in grazing equines. here, fecal samples collected from 1221 thoroughbred horses, residing at 22 studs in the uk, were analysed. the distribution of strongyle eggs amongst individuals in relation to age, gender and management practices was investigated. fecal worm egg counts (fwecs), described as the number of eggs per gramme (epg) of feces, were determined usin ...201323351718
surgical treatment for acute small intestinal obstruction caused by parascaris equorum infection in 15 horses (2002-2011).there is a consensus in the veterinary literature that parascaris equorum (ascarid) impaction carries a poor prognosis. hence surgery is often delayed and foals are often subjected to euthanasia after diagnosis of ascarid impaction is established. our clinical impression was that ascarid impaction carries a better prognosis than previously reported.201223447889
prevalence and intensity of gastro-intestinal helminths in horses in the sudano-guinean climatic zone of cameroon.it is important to understand the biology and health impact of parasites affecting horses in the western highlands of cameroon.201223508513
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