| observations on malaria in an industrial area of chotonagpur. | | 1978 | 383847 |
| synchronization of plasmodium falciparum erythrocytic stages in culture. | synchronous development of the erythrocytic stages of a human malaria parasite, plasmodium falciparum, in culture was accomplished by suspending cultured parasites in 5% d-sorbitol and subsequent reintroduction into culture. immediately after sorbitol treatment, cultures consisted mainly of single and multiple ring-form infections. at the same time, varying degrees of lysis of erythrocytes infected with the more mature stages of the parasite was evident. approximately 95% of the parasites were i ... | 1979 | 383936 |
| plasmodium falciparum in culture: improved continuous flow method. | a new design of flow vessel provides a method for continuous culture of p. falciparum in a settled layer of human erythrocytes with a slow flow of culture medium over them. the parasitemia is kept fluctuating from approximately 1%, just after addition of fresh erythrocytes, to approximately 10%, 2 or 3 days later. each vessel provides each week 3 harvests, each containing approximately 0.6--1 x 10(9) parasites. | 1979 | 383969 |
| observations on gametogenesis in plasmodium falciparum from continuous culture. | gametocytes of plasmodium falciparum were produced in continuous cultures but eventually declined in numbers after 3--4 months in vitro. their development progressed in a consistent pattern, from small rounded, through triangular, to ellipsoidal, and finally after 8 days to crescentic forms. morphologic maturity occurred at 8--9 days, but the gametocytes would not exflagellate in vitro, even after 14--18 days of development. thus, current culture methods cannot produce a continuous supply of fun ... | 1979 | 383970 |
| [aspects of malaria epidemiology in the people's democratic republic of yemen]. | | 1979 | 384190 |
| [pressing problems of malaria prevention in the ussr]. | | 1979 | 384191 |
| [autochtone malaria]. | | 1979 | 384362 |
| the effect of prednisolone on red cell survival in patients with falciparum malaria. | radioisotope red-cell survival studies were carried out in 20 patients with falciparum malaria following quinine therapy. the mean parasite clearance time of the patients receiving quinine sulfate was 49 hours and those of the patients receiving quinine sulfate and prednisolone was 46 hours. the red-cell survival was correlated with the initial hematocrit level in both groups but the daily dose of 40 mg prednisolone did not mitigate the red cell survival. | 1979 | 384543 |
| treatment of falciparum malaria in thai children. | | 1979 | 384544 |
| in vivo and in vitro studies of quinine sensitivity of plasmodium falciparum in thailand. | forty-four patients with falciparum malaria were studied. nine patients were given quinine orally at a daily dose of 1.5 gm base for a period of 14 days. the mean parasite clearance in all 9 patients was 3.3 days, and none had recrudescence in follow-up examinations for 31 days. the in vivo study of these 9 patients showed sensitivity to quinine which correlated with the in vitro test, with concentration of quinine base 2.5-5.8 microgram/ml of blood that inhibited the maturation of plasmodium fa ... | 1979 | 384545 |
| [accidentally induced malaria]. | | 1979 | 384632 |
| the role of hemoglobins c, s, and nbalt in the inhibition of malaria parasite development in vitro. | the host cell competence of hemoglobin c (hbc)-containing erythrocytes for plasmodium falciparum was studied by in vitro culture. hbc homozygous red cells did not support the growth of the intracellular parasite. heterozygous cells, however, were competent. in addition, hbc increased the resistance of sicle cell hemoglobin (hbs) red cells when present in the double heterozygote, sc, cultured at low oxygen tension. this effect most likely resulted from the ability of hbc to enhance the sickling o ... | 1979 | 384816 |
| drug-resistant falciparum malaria among the mayongong indians in the brazilian amazon. | in april of 1977 an outbreak of falciparum malaria occurred among the mayongong indians, located at uauaris in the territory of roraima, brazil. blood specimens from 157 indians were examined for plasmodium; 62 were found to be infected. in three cases the infection was not cured with chloroquine but responded favorably to the drug combination of sulfadoxine and pyrimethamine (fansidar). | 1979 | 384818 |
| [autochthonous malaria and malarian liver. apropos of 1 case]. | report of the case of a patient, store-keeper at the roissy airport, suffering from an autochtonous primo-invasion falciparum malaria. the clinical symptoms were hectic fever and painful hepatomegalia, followed 14 days after by a typical tertian fever. all investigations being negative, a laparoscopy was carried out, which showed a black liver, and a biopsy demonstrated the malaria pigment in küpffer cells. malaria was confirmed by the study of a blood smear. this diagnostic hypothesis had not ... | 1978 | 385159 |
| ultrastructural damage to the malaria parasite in the sickled cell. | the process by which malaria parasites are killed in sickled erythrocytes was studied by electron microscopy. in vitro cultures of plasmodium falciparum in sickle cell hemoglobin (hbs) homozygous (ss) and heterozygous (sa) red cells were deoxygenated for up to 6 h and fixed under anaerobic conditions. parasites in ss cells appeared to be disrupted by intrusions of needle-like deoxyhbs aggregates; disintegration of cytoplasm and membranes followed. in sa red cells, the parasites were generally no ... | 1979 | 385855 |
| malaria in australia. | | 1979 | 386057 |
| chloroquine-resistant falciparum malaria. | | 1979 | 386060 |
| [a patient with tropical malaria acquired in a south african safari park]. | | 1979 | 386142 |
| [successes of modern malariology]. | malariological situation analysis in the ussr and world over testifies to increasing malaria incidence particularly in the countries where earlier it was almost fully eradicated. malaria epidemics in these countries (posteradication epidemics) is a new phenomenon in malariology. temporary success of the global campaign of malaria eradication has led to a deadlock in malariology which during the past 10 years is being successfully overcome. achievements of modern malariology are reviewed in the a ... | 1979 | 386234 |
| antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria. | serum samples from 158 west africans were tested for antibodies against sporozoites, the vector stage of the malaria parasite. antibodies specific for plasmodium falciparum sporozoites were detected by means of the circumsporozoite precipitation assay and indirect immunofluorescence. more than 90 percent of the serum samples from adults gave positive immunofluorescent reactions against falciparum sporozoites, whereas most of the samples from children gave low or negative reactions. | 1979 | 386511 |
| abnormal haemoglobins in the sudan savanna of nigeria. ii. immunological response to malaria in normals and subjects with sickle cell trait. | children born in areas hyperendemic for plasmodium falciparum are protected by maternal antibodies for up to about five months of life, after which they are subject to intense infection until they acquire sufficient immunity--by about five years of age. children with sickle cell trait (hb.as) are at an advantage during these critical years, probably because of preferential phagocytosis of parasitized red cells. this could lead to either (i) early processing of antigen by macrophages and an accel ... | 1979 | 386969 |
| studies on plasmodium falciparum in continuous cultivation. i. the effect of chloroquine and pyrimethamine on parasite growth and viability. | recent advances in the in vitro study of human malaria have provided the knowledge to maintain plasmodium falciparum in continuous culture. using relatively cheap and easily obtainable materials it is now possible to study many parameters including parasite chemotherapy. the activity of two standard antimalarials, chloroquine and pyrimethamine, has been examined in vitro. the effect on the parasite is easily observed and can be measured not only as a decrease in parasite density, but also as the ... | 1979 | 386970 |
| genetics of red cells and susceptibility to malaria. | | 1979 | 387115 |
| chloroquine-resistant falciparum malaria. | | 1979 | 388167 |
| tetraethylthiuram disulfide (antabuse) inhibits the human malaria parasite plasmodium falciparum. | plasmodium falciparum in culture grows optimally at 3% oxygen. oxygen levels down to 0.5% still support growth, but anaerobic conditions do not. these findings, and the absence of the krebs cycle in plasmodium, suggested that in this organism oxygen may not function in electron transport but rather may act through metalloprotein oxygenases. tetraethylthiuram disulfide (antabuse, disulfiram) and its reduction product diethyldithiocarbamate inhibit many metalloprotein oxygenases and have a lipid/h ... | 1979 | 388434 |
| characterization of a protein correlated with the production of knob-like protrusions on membranes of erythrocytes infected with plasmodium falciparum. | membranes of erythrocytes infected with plasmodium falciparum develop protrusions called "knobs." these protrusions are not apparent on erythrocytes infected with young parasites (rings) but develop with the growth of parasites to the trophozoite and schizont stages. the nature and origin of knobs were characterized by comparing the stage-specific proteins of two culture lines of p. falciparum, k+ and k-. k+ parasites produce knobs; k- parasites do not. erythrocytes infected with both types of p ... | 1979 | 388448 |
| possible chloroquine-resistant plasmodium falciparum in nigeria. | a 42-year-old hospital worker had a recrudescence of falciparum malaria after chloroquine therapy. further adequate treatment with chloroquine given orally did not clear the infection. he was then given a combination of sulphadiazine and pyrimethamine, which produced a radical cure. this points to the possibility of chloroquine-resistant plasmodium falciparum in nigeria, an african country where this has been thought to be unlikely. because of this and earlier reports, clinicians should be on th ... | 1979 | 389072 |
| the enzyme-linked immunosorbent assay (elisa) for malaria. ii. comparison with the malaria indirect fluorescent antibody test (ifa). | | 1979 | 389073 |
| chloroquine-resistant falciparum malaria in a bangladeshi girl with acute lymphoblastic leukaemia. | | 1979 | 389343 |
| cerebral malaria in the united kingdom. | four fatal cases of cerebral plasmodium falciparum malaria in english travellers returning from africa have been seen in the last 13 years. the haemorrhages, accumulations of microglia, and destruction of cerebral white matter around small veins as a result of blockage of cortical capillaries by parasitised red blood corpuscles resemble the effect of fat embolism. microglia in the lesions is demonstrated by special neuropathological techniques. attention is drawn to the need for a prompt recogni ... | 1979 | 389955 |
| [tropical malaria contracted the natural way in the netherlands]. | | 1979 | 390409 |
| [in vitro cultivation of plasmodium falciparum as a first step in the development of a malaria vaccine]. | | 1979 | 390410 |
| [demonstration of soluble parasite antigens, the corresponding antibodies and immune complexes in acute malaria]. | serum levels of malaria antigens, antimalaria antibodies, immune complexes and complement components have been followed up in 23 patients suffering from acute malaria infection and recovering under therapy. malarial antigens in serum were detected by counterimmunoelectrophoresis: the peak was observed before therapy started and their levels rapidly decreased. specific antimalarial antibodies became detectable 5--7 days after starting treatment in patients with a first infection. immune complexes ... | 1979 | 390695 |
| exchange transfusion in cerebral malaria complicated by disseminated intravascular coagulation. | a patient with cerebral malaria complicated by full-blown dic, after failing to respond to other forms of treatment, was successfully treated by exchange transfusion. to the best of the authors' knowledge, this may be first reported case of full-blown dic in malaria successfully treated by exchange transfusion. | 1979 | 390723 |
| bleeding diathesis in tropical diseases. | | 1979 | 390724 |
| studies on the occurrence of a strain of chloroquine-resistant plasmodium falciparum in papua new guinea. | | 1978 | 390920 |
| which prophylactic drugs for malaria? | | 1979 | 391331 |
| haemoglobin a2 in malaria. | | 1979 | 391709 |
| treatment and chemoprophylaxis of malaria. | | 1979 | 392489 |
| the concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and 'double' dosage in non-immunes: clinical implications. | the concentration of chloroquine in serum was analysed after one week, six weeks and one year on standard dose prophylaxis (300 mg chloroquine base once a week) and after six months on the double dose. after six weeks, the standard dose gave adequate protection against malaria. during the first weeks of prophylaxis insufficient protection might be achieved by the customary standard dose. in a double-dose group many values reached the point above which a higher incidence of side-reactions have be ... | 1979 | 393188 |
| in vitro response of chloroquine-resistant plasmodium falciparum to mefloquine. | the present study was conducted to evaluate the application of the in vitro microtechnique system in determining the response of chloroquine-resistant plasmodium falciparum to mefloquine.using isolates of p. falciparum from boa vista, brazil, and villavicencio, colombia, mefloquine was more than 7.7, 7.1, 7.1, and 6.4 times more effective than chloroquine in vitro at the ed(90), ed(95), ed(99), and ed(99.9) levels, respectively. | 1979 | 393426 |
| serum immunoglobulin concentrations, malarial and schistosomal antibodies in patients with massive splenomegaly in malawi. | serum immunoglobulin concentrations, malarial antibodies and schistosomal antibodies were measured in 33 patients with a provisional diagnosis of schistosomal splenomegaly, 16 with tss of presumed malarial aetiology and in 52 controls. igg and igm were higher in both splenomegaly groups than in the controls and igg was significantly higher in patients with schistosomal splenomegaly than in tss. although a very high igm was found more often in the tss group, there was no significant difference be ... | 1979 | 393837 |
| [epidemiological study of onchocerciasis and malaria in bamendjin dam area (cameroon). malacologic fauna and risks of schistosomian introduction (author's transl)]. | report of survey in bamendjin dam area indicates that 25 p. 100 of the population have a blood smear positive for malaria (p. falciparum) and 80 p. 100 have a positive indirect immunofluorescent test for malaria. the vector is a. funestus. in male inhabitants 23,2 p. 100 of the snip-biopsies are positive for o. volvulus and 40 p. 100 of the indirect immunofluorescent test are positive. in female inhabitants the respective ratios are 14,4 p. 100 and 48,8 p. 100. there is no urinary or intestinal ... | 1979 | 393936 |
| [central nervous system involvement in parasitic tropical diseases]. | | 1979 | 393944 |
| malaria in tonga: an imported case. | a case of falciparum malaria in tonga occurring in a tourist is reported and discussed with the emphasis on awareness of imported diseases to the pacific. | 1979 | 394052 |
| [malaria caused by plasmodium falciparum, with acute renal failure]. | | 1979 | 394232 |
| in vitro observations on hereditary spherocytosis and malaria. | | 1979 | 394413 |
| abo blood groups and falciparum malaria. | | 1979 | 394415 |
| quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. | a rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against cultured intraerythrocytic asexual forms of the human malaria parasite plasmodium falciparum. microtitration plates were used to prepare serial dilutions of the compounds to be tested. parasites, obtained from continuous stock cultures, were subcultured in these plates for 42 h. inhibition of uptake of a radiolabeled nucleic acid precursor by the parasites served as the in ... | 1979 | 394674 |
| malaria in rural quebec: the impossible infection. | | 1979 | 394827 |
| unexplained falciparum malaria in a patient with chronic lymphocytic leukemia. | | 1979 | 394830 |
| [the reaction of hyperbasophilic mononucleated cells during p. falciparum malaria; its role in the immune response]. | in 34 patients with a primary attack of p. falciparum malaria, hyperbasophilic mononucleated cells (atypical lymphocytes) were found 22 times. these cells appeared around the 3rd or 4th day of fever and represented 4 to 10% of all white blood cells in 14 cases, 10 to 15% in 6 cases, and 15 to 21% in 2 cases. their transitory appearance seems to reflect the involvement of cell-mediated immunity, and more specifically of k cell-related cytotoxicity. | 1979 | 394863 |
| gametocytogenesis of plasmodium falciparum in vitro: the cell-cycle. | reproducible growth of gametocytes of plasmodium falciparum in vitro was obtained from ring-stages taken directly from naturally infected patients and from the same material following storage in liquid nitrogen. progressive sexual differentiation in vitro was examined for a finite period of 9 days in microcultures and was, for convenience, divided into 5 stages using established morphological criteria (hawking, wilson & gammage, 1971). this microculture system was adapted as a bioassay for vario ... | 1979 | 395486 |
| the sequestration of plasmodium falciparum infected erythrocytes in the placenta. | | 1979 | 395729 |
| [case of heterozygotic sc hemoglobinopathy with high titre of indirect immunofluorescence reaction with plasmodium falciparum antigen]. | the authors report the first in the polish literature case of combined heterozygotic sc haemoglobinopathy in a nigerian aged 20 years. the diagnosis was based on the results of haemoglobin electrophoresis and clinical signs. the titre of ifp with plasmodium falciparum was very high and malarial pigment was found in lymph nodes. | 1979 | 395806 |
| [imported malaria in a tropical unit in paris. about 100 cases (author's transl)]. | from a hundred cases of imported malaria observed in paris, the authors emphasize the following points: annual increase of cases, lack or inadequacy of prophylaxis, frequent reinfestations among black africans living in france, and comming back in endemic area for a brief journey, high risks for pregnant women. | 1979 | 395872 |
| chemotherapy of falciparum malaria: regional differences in responsiveness to treatment. | a review of chloroquine and sulfa-antifol combination treated falciparum malaria patients revealed a high incidence of chloroquine-resistance, wither r1 or r2, in patients infected in southeast asia or oceania. in addition, more than one tenth of the patients infected in laos or thailand were resistant to sulfa-antifol combinations. chloroquine-resistant cases were sensitive to sulfa-antifol combinations. on the other hand, while all patients treated in tokyo who had been infected in africa or s ... | 1979 | 396391 |
| the pattern of parasitic infection in villages of lagos state, nigeria. | | 1979 | 396698 |
| caps jottings on malaria. 4. ronald ross. | | 1979 | 396986 |
| proteins and glycoproteins from human erythrocytes infected with plasmodium falciparum. | the purpose of this study was to determine whether metabolites of parasite origin are incorporated into the "knob-like" protrusions of membranes of erythrocytes infected with plasmodium falciparum. intraerythrocytic parasites were grown in culture and labelled metabolically with ((35)s)-methionine. fractions enriched in membranes with knobs and fractions poor in knobs were prepared and analysed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. labelled components were visualized by a ... | 1979 | 397004 |
| fractionation and characterization of plasmodium falciparum antigens. | in human malarial infections, the immunological importance of modified host cell components and of parasite antigens that may be released on spontaneous rupture of infected erythrocytes in vivo is not known. it is difficult, however, to analyse antigens extracted from entire parasitized red cells because of contamination with normal red cell constituents, notably haemoglobin. to overcome this problem, a simple chromatographic procedure has been developed that concentrates antigens and radiolabel ... | 1979 | 397005 |
| some aspects of serum requirements for continuous cultivation of plasmodium falciparum. | as possible substitutes or supplements for the human serum requirements for continuous cultures of plasmodium falciparum several different animal sera have been tried, including: fresh fetal bovine, sheep, horse, adult bovine, newborn calf, swine, commercially supplied fresh-frozen or lyophilized human sera, fatty acid-free bovine or human serum albumin, red cell extract, physiogel, and a serum substitute composed of bacto-peptone, yeastolate, lactalbumin hydrolysate, polyvinylpyrrolidone, and b ... | 1979 | 397006 |
| in vitro propagation of plasmodium falciparum for merozoite antigens. | a system with continuous flow of medium that uses disposable tissue culture flasks for the in vitro cultivation of p. falciparum is described. this scaled-up modification of the trager and jensen method gives merozoite yields sufficient for experimental vaccine studies in animals. a method of increasing the yield of merozoites by decreasing the ph of the medium is presented. | 1979 | 397007 |
| evidence for environmental modulation of gametocytogenesis in plasmodium falciparum in continuous culture. | with the introduction of continuous culture of plasmodium falciparum it has become possible to study the factors involved in gametocyte production in vitro and thus eliminate the uncontrollable in vivo variables of the host. the authors have developed a method for measuring quantitatively the rate of production of gametocytes at any time in such cultures. the method is based on an estimation of the percentage of ring forms that develop into stage ii gametocytes.using this approach, it was found ... | 1979 | 397008 |
| harvest of plasmodium falciparum merozoites from continuous culture. | spontaneously released merozoites were harvested from cultures in which 42-90% of the erythrocytes had been infected with mature forms of plasmodium falciparum at the start of incubation. the mature forms had been extracted from asynchronous cultures by the use of ficoll and plasmagel gradients. as the mature forms consisted of both trophozoites and schizonts, merozoites were released into the culture medium over a long period of time. the synchrony of merozoite release did not appear to be impr ... | 1979 | 397009 |
| in vitro production and partial purification of plasmodium falciparum antigen. | a simple technique for achieving high yields of plasmodium falciparum parasites on a continuous basis is described. the technique is applicable in any laboratory. the culture apparatus is also simple and inexpensive and allows multiple cultures to be run simultaneously. a total of approximately 1-2 x 10(9) parasites can be harvested per culture flask per week requiring the use of only 40.0 ml of culture medium (rpmi 1640), 5.0 ml of human sera, and 2.0 ml of outdated human whole blood. p. falcip ... | 1979 | 397010 |
| recent developments in enlarging the scale of production of plasmodium falciparum in vitro. | several methods are described for the cultivation of plasmodium falciparum. they include cultivation in (a) flow vessels that contain 12 ml of rbc suspension and are harvested three times a week, (b) a "tipper" that provides a similar yield, and (c) more recently, a large flat-bottomed vessel that holds 75 ml of suspension. attempts are being made to develop techniques for synchronizing the cultures. | 1979 | 397012 |
| some aspects of p. falciparum containment programme. | | 1979 | 398330 |
| chloroquine resistance in p. falciparum in assam state. | | 1979 | 398331 |
| in vivo chloroquine sensitivity tests of plasmodium falciparum in some parts of uttar pradesh and haryana states. | | 1979 | 398332 |
| results of chloroquine sensitivity tests in p. falciparum in some districts of gujarat and maharashtra states. | | 1979 | 398333 |
| results of in vivo chloroquine sensitivity tests in plasmodium falciparum in some parts of karnataka state. | | 1979 | 398334 |
| a note on chloroquine resistance tests on p. falciparum in nagaland. | | 1979 | 398335 |
| response of plasmodium falciparum to chloroquine in the meghalaya state. | | 1979 | 398336 |
| results of chloroquine sensitivity tests in plasmodium falciparum in orissa state. | | 1979 | 398337 |
| response to chloroquine with and without pyrimethamine in plasmodium falciparum in west bengal, tripura, mizoram, manipur and arunachal pradesh. | | 1979 | 398338 |
| results of presumptive treatment of malaria in orissa state. | | 1979 | 398339 |
| a preliminary report on serological studies on malaria in the rural population of karnataka state. | | 1979 | 398342 |
| studies on malaria transmission in two selected villages in alwar, rajasthan. | | 1979 | 398343 |
| simultaneous propagation of p. malariae and p. falciparum in a continuous culture. | | 1979 | 398344 |
| some transfusion-induced parasitic infections in zambia. | the risk of acquiring a transfusion-induced infection in zambia was studied for the first time. blood slide examination of donors, despite the insensitivity of the method, established malaria as the most serious hazard. the species involved was plasmodium falciparum, the cause of cerebral malaria, and which could be rapidly fatal in a non-immune host visiting an endemic area. microfilariae of dipetalonema perstans and wuchereria bancrofti were also found in donor populations. while no disease ma ... | 1979 | 399289 |
| [erythrocyte blood groups and geographic pathology (author's transl)]. | blood groups are an obstacle to reproduction, transfusion and transplantation. there are immunological abortions due to the antibodies of "p" phenotype women; and rh haemolytic disease of the new-born is in direct proportion to the frequency of the "r" gene in a given population; the problem of transfusional allo-immunisation is completely parallel. certain membrane anomalies (due to exceptional erythrocyte blood groups--rh null, rh mod or mcleod, for example), can provoke hemolytic anaemias, bu ... | 1979 | 400037 |
| [anti-malaria chemical prophylaxis in europeans and anti-plasmodium fluorescence antibodies]. | the authors recorded clinical histories and tested serum for the presence of malaria fluorescent antibodies in 160 healthy europeans who had been living for more than 4 weeks in west or central africa. malaria or fever of unknown origin occurred in 37 of 50 subjects who were careless about taking prophylactic drugs while abroad. out of 110 people regularly taking suppressive amino-4-quinoline therapy, 21 had presented febrile attacks but serological tests were only positive in 8 cases. positive ... | 1979 | 400122 |
| falciparum malaria and pregnancy. | during pregnancy an increase occurs in the prevalence and density of plasmodium falciparum malaria. the increase relative to non-pregnant women remains fairly constant with age though there is an over-all decrease in prevalence and density in both groups with age. the increase is at a height relatively early in pregnancy and declines after mid-term. at the height of the malaria season in the gambia less antimalarial antibody appears in cord bloods than in the early dry season when transmission i ... | 1979 | 400205 |
| [a rare cause of subdural effusion in children : cerebral malaria (author's transl)]. | | 1979 | 400277 |
| short term in vitro cultivation of malaria parasites in papua new guinea for preparation of biosynthetically-labelled parasite antigens. | short term in vitro cultivation has been used successfully for biosynthetic labelling of tca precipitable macromolecules of papua new guinean isolates of plasmodium falciparum. conditions satisfactory for completion of the asexual erythrocytic cycle were achieved with aa minimum of sophisticated equipment. the techniques used are described in detail and mention is made of possible applications to assessment of chloroquine resistance and the mode of action of inhibitory antisera. | 1979 | 400462 |
| studies on the nature of thyroidal suppression during acute falciparum malaria: integrity of pituitary response to trh and alterations in serum t3 and reverse t3. | the nature of the suppression of the pituitary-thyroid axis during infection was studied by testing the integrity of thyrotropin (tsh) and prolactin (prl) responses to thyrotropin-releasing hormone (trh) during acute falciparum malaria in human volunteers. during infection, tsh responses to trh were found to be intact while prl secretion was slightly increased. that serum t3 levels abruptly declined during infection while serum t4 was stable or increasing suggested an alteration in peripheral de ... | 1977 | 401826 |
| spleen-derived mononuclear cell chemotactic factor in malaria infections: a possible mechanism for splenic macrophage accumulation. | | 1977 | 402418 |
| drug-resistant malaria. | | 1977 | 402541 |
| sporozoite transmission of falciparum malaria (burma-thau. strain) from man to aotus monkey. | a sporozoite-induced infection of plasmodium falciparum (burma-thau. strain) was established in splenectomized aotus trivirgatus which received prior treatment with dlmethionine as a dietary supplement. this is the first recorded instance of infection of an aotus monkey with falciparum sporozoites of human origin. | 1977 | 402864 |
| studies on the santa lucia (el salvador) strain of plasmodium falciparum in aotus trivirgatus monkeys. | the santa lucia strain of plasmodium falciparum was isolated from el salvador, central america, and established in aotus trivirgatus monkeys. transmission from monkey to monkey via the bites of infected anopheles freeborni, a. maculatus, and a, albimanus mosquitoes was obtained in 20 of 27 attempts. prepatent periods in the monkeys ranged from 17 to 46 days with a mean of 24.3 days. parasitemias and mortality were higher following sporozoite inoculation into animals which had been previously inf ... | 1977 | 403272 |
| infectivity of the santa lucia (el salvador) strain of plasmodium falciparum to different anophelines. | anopheles freeborni mosquitoes were much more heavily infected with the santa lucia strain of plasmodium falciparum from coastal el salvador than were any of the other species tested. of 5 strains of a. albimanus examined, the most heavily infected was the ca-109a and the least was the melara, both of which come from coastal el salvador. of the exotic anophelines, the a. maculatus was infected at a slightly higher level than was the a. balabacensis. the incidence of highly infected individual mo ... | 1977 | 403273 |
| plasmodium falciparum and plasmodium coatneyi: immunogenicity of "knob-like protrusions" on infected erythrocyte membranes. | | 1977 | 405234 |
| an effective immunization of experimental monkeys against a human malaria parasite, plasmodium falciparum. | this is the first report of successful immunization of experimental monkeys against a human malaria parasite, plasmodium falciparum. of the five owl monkeys (aotus trivirgatus) used in this pilot study, two served as controls and the other three were immunized with p. falciparum antigen consisting primarily of mature segmenters containing fully developed merozoites. two injections of antigen emulsified with freund's complete adjuvant were administered intramuscularly 3 weeks apart. three weeks a ... | 1977 | 406671 |
| activities of various 4-aminoquinolines against infections with chloroquine-resistant strains of plasmodium falciparum. | the studies reported here stemmed from a personal report by geiman on the capacity of the 4-aminoquinoline amodiaquin to inhibit in vitro maturation of ring stages of the chloroquine-resistant monterey strain of plasmodium falciparum. this observation, confirmed in owl monkeys infected with this strain, led to a comparison of the activities of chloroquine, amodiaquin, amopyroquin, and dichlorquinazine (12,278 rp) against infections with various chloroquine-susceptible and chloroquine-resistant s ... | 1977 | 406829 |
| quantitative aspects of pyrimethamine-sulfonamide synergism. | the experiments described in this report have dealt with the dimensions of therapeutic potentiation achieved when combinations of pyrimethamine and sulfadiazine were administered to rhesus monkeys infected with a drug-susceptible strain of plasmodium cynomolgi or its pyrimethamine-resistant variant and to owl monkeys infected with strains of p. falciparum and p. vivax of varying degrees of resistance to this pyrimidine. these evaluations showed: 1) that when delivered in combination, the activit ... | 1977 | 410317 |
| hypothesis on the mechanism of erythrocyte invasion by malaria merozoites. | plasmodium knowlesi merozoites invade erythrocytes by a sequence of events: attachment, widespread deformation of the erythrocyte membrane, endocytosis, and resealing of the membrane and vesicle. the possible mechanisms by which these events occur are discussed. in particular, there is a detailed discussion of the role of the duffy blood group system in invasion. | 1977 | 412599 |
| an effective immunization of aotus trivirgatus monkeys against plasmodium falciparum: a research note. | | 1977 | 412606 |
| effects of autologous plasma on lymphocyte transformation in malaria and in acute protein-energy malnutrition. comparison of purified lymphocyte and whole blood cultures. | phytohaemagglutinin (pha) induced lymphocyte transformation in whole blood and in purified lymphocyte cultures was investigated in gambian children with acute plasmodium falciparum malaria or with acute protein-energy malnutrition (pem). responses of purified lymphocytes cultured in the absence of autologous plasma were normal, with one exception. autologous plasma depressed the response of purified lymphocytes to a low dose of pha in several malaria and pem patients. in whole blood cultures of ... | 1977 | 412777 |
| immunoprophylaxis of malaria: sporozoite-induced immunity. | | 1977 | 413344 |