Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| a quinoline methanol (wr 30090) for treatment of acute malaria. | wr 30090 at a dose of 230 mg every 8 hr for 6 days has proven to be a safe, well-tolerated compound with photosensitivity proving to be a minor consideration. wr 30090 was found to be an effective medication for the treatment of acute malaria caused by several strains of plasmodium falciparum. at the dose of 230 mg every 8 hr for 6 days, all of six men infected with a chloroquine-susceptible strain (uganda i) were cured, all of 13 subjects infected with moderately chloroquine-resistant strains ( ... | 1973 | 4597715 |
| prophylactic activity of a phenanthrene methanol (wr 33063) and a quinoline methanol (wr 30090) in human malaria. | wr 33063 (3-bromo-10-[alpha-hydroxy-beta-(n, n-diheptylamino)ethyl]-phenanthrene hydrochloride) and wr 30090 (6,8-dichloro-2,3,4-dichlorphenyl-di-n-butylaminoethyl-4- quinolinemethanol hydrochloride) were tested for suppressive prophylactic effect on induced malaria in nonimmune volunteers living in an area where malaria is not naturally transmitted. doses of 800 mg of wr 33063 and 690 or 460 mg of wr 30090 were given at weekly intervals to men exposed on the day of the first dose to mosquitoes ... | 1973 | 4597716 |
| treatment of falciparum malaria from vietnam with a phenanthrene methanol (wr 33063) and a quinoline methanol (wr 30090). | two new investigational antimalarial drugs developed by the u.s. army malaria research program were tested in patients with multi-drug-resistant falciparum malaria from vietnam. wr 33063, a phenanthrene methanol, cured 13 patients treated in the united states. all of these patients had suffered multiple recrudescences after treatment with standard antimalarial drugs. in addition, 23 of 25 patients with acute attacks of falciparum malaria treated in vietnam were cured. the rate of clinical respon ... | 1973 | 4597717 |
| sulfalene with pyrimethamine and chloroquine with pyrimethamine in single-dose treatment of plasmodium falciparum infections. a trial in a rural population in northern nigeria. | a comparative trial was carried out in northern nigeria of the ability of the drug combinations chloroquine-pyrimethamine and sulfalene-pyrimethamine to clear the peripheral blood stream of asexual forms of p. falciparum within 7 days. the reappearance of asexual p. falciparum forms within the 70-day follow-up period and the occurrence of vomiting during the 2-3 hours following administration of the drugs were also recorded. the purpose of the trial was to choose the more suitable of the two dru ... | 1973 | 4603037 |
| malaria in china and the equatorial pacific area from 1937 to 1943. | 1973 | 4611054 | |
| the challenge of drug-resistant malaria. | 1973 | 4631761 | |
| igm antibodies to red cells and autoimmune anemia in patients with malaria. | 1973 | 4631762 | |
| second roundtable discussion on taxonomic problems relating to malaria parasites. | 1973 | 4632261 | |
| rigidity of red cell during malarial infection. | 1973 | 4632768 | |
| [parasitology and splenomegaly]. | 1973 | 4599750 | |
| seroepidemiological evidence of eradication of malaria from mauritius. | 1973 | 4125305 | |
| the sensitivity of some human and simian haemosporidial antigens to detect fluorescent antibodies against human plasmodia. | 1973 | 4126540 | |
| serum glycoproteins and malaria in ethiopia. | 1973 | 4128005 | |
| identification of malaria parasites by fluorescence microscopy and acridine orange staining. | the need for a technique that is more sensitive than the use of romanowsky-stained thick blood films for detecting malaria parasites at low concentration in the blood is well recognized. one of the more promising methods appeared to be fluorochrome staining with acridine orange. however, reports on the efficacy of the technique were contradictory and it was not clear to what extent blood films taken under survey conditions would contain fluorescing artefacts that might confuse diagnosis. an inve ... | 1973 | 4130021 |
| enzyme typing of malaria parasites. | analysis of various isolates of plasmodium falciparum from east and west africa and from south-east asia showed that some of the parasite enzymes can exist in more than one electrophoretic form. at least one form of each enzyme was common to parasites from all three regions. the enzyme forms could be used to differentiate morphologically indistinguishable samples of p. falciparum. | 1973 | 4196338 |
| plasmodium falciparum and p. knowlesi: low temperature preservation using dimethylsulfoxide. | 1973 | 4197973 | |
| cross immunity studies with east and west african strains of plasmodium falciparum in owl monkeys (aotus trivirgatus). | 1973 | 4198111 | |
| prophylaxis of malaria in man using the sulfone dfd with pyrimethamine. | 1973 | 4198482 | |
| studies on human malaria in aotus monkeys. ii. establishment of a strain of plasmodium falciparum from panama. | 1973 | 4198647 | |
| comparison of precipitation malarial antibodies produced by indigenous immune gambians and an infected european. | 1973 | 4198756 | |
| the stability and fractionation of malarial antigens from the blood of africans infected with plasmodium falciparum. | 1973 | 4199255 | |
| chloroquine-resistant plasmodium falciparum: difference in the handling of 14c-amodiaquin and 14c-chloroquine. | (14)c-amodiaquin and (14)c-chloroquine were used to study drug binding by preparations of owl monkey erythrocytes infected either with a chloroquine-susceptible (cs) or with a chloroquine-resistant (cr) strain of p. falciparum. both of these drugs are derivatives of 4-aminoquinoline, but they differ in their side chains, and there are differences in the way they are handled by preparations of erythrocytes infected with malaria parasites. although the apparent association constant for the binding ... | 1973 | 4208293 |
| [treatment of cerebral malaria with a fansidar-hydergine combination]. | 1973 | 4206282 | |
| enzyme variants in primate malaria parasites. | 1973 | 4204741 | |
| 6-phosphogluconate dehydrogenase activity in malaria-infected erythrocytes. | 1973 | 4204745 | |
| a multi-species malaria antigen for use in the indirect fluorescent antibody test. | 1973 | 4204753 | |
| preparation and use of malarial placenta antigen for immunodiffusion studies in a nigerian population. | 1973 | 4205104 | |
| experience with mixed infections of plasmodium falciparum and vivax. | 1973 | 4200077 | |
| chemotherapy of malaria and resistance to antimalarials. report of a who scientific group. | 1973 | 4200089 | |
| suppression of plasmodium falciparum malaria in aotus monkeys by milk diet. | 1973 | 4200243 | |
| glomerular changes in acute plasmodium falciparum infection. an immunopathologic study. | 1973 | 4200428 | |
| immunoglobulin characteristics of antibodies to malarial s-antigens in man. | 1973 | 4200439 | |
| transmission of three strains of plasmodium falciparum from monkey to man. | 1973 | 4200700 | |
| heterologous immunity in human malaria. | 1973 | 4201093 | |
| malaria in vietnam (i corps sector): review of 214 cases including eeg patterns on 19 acutely ill patients. | 1973 | 4203605 | |
| absence of circulating interferon in patients with malaria and with american trypanosomiasis. | 1973 | 4203819 | |
| detection of malarial antibodies in man by fluorescent antibody test using plasmodium gallinaceum as antigen. | 1973 | 4147876 | |
| new developments in glucose-6-phosphate dehydrogenase deficiency. | 1973 | 4152522 | |
| antibodies against sporozoites of human and simian malaria produced in rats. | 1973 | 4405323 | |
| infections with plasmodium falciparum and plasmodium vivax in the owl monkey--model systems for basic biological and chemotherapeutic studies. | 1973 | 4206524 | |
| characterization of a drug resistant strain of plasmodium falciparum from burma. | 1973 | 4266743 | |
| bongkrekic acid and the adenosinetriphosphate requirement of malaria parasites. | 1973 | 4272633 | |
| comparison of indirect haemagglutination and immunofluorescence tests for malaria antibody in aotus monkeys infected with plasmodium falciparum. application of indirect haemagglutination tests for malaria. | longitudinal observations were made on 6 aotus monkeys repeatedly infected with plasmodium falciparum (west african and palo alto strains). immunofluorescence titres were higher than indirect haemagglutination titres in the primary phase of the infections. both serological tests were consistently positive later in the infections. precipitins were often not detectable even during episodes of parasitaemia. | 1973 | 4211057 |
| application of the indirect haemagglutination test for malaria: reproducibility with plasmodium falciparum-sensitized cells. | the reproducibility of the iha test was assessed. two batches of glutaraldehyde-fixed sheep cells were used and the cells were sensitized with different batches of p. falciparum antigen obtained from 4 owl monkeys. at the individual level the iha test appears to have a reproducibility of approximately 90%. | 1973 | 4211058 |
| immunity and malaria in man. | 1974 | 4212067 | |
| the production of antigens by plasmodium falciparum in vitro. | 1974 | 4213471 | |
| immunopathology of malaria. | antibodies with different spectra of reactivity are produced during malarial infections and marked changes in igg and igm levels occur. in addition malaria elicits serological changes that are usually associated with connective tissue disease. the excessive anaemia associated with malaria may, in part, be an autoimmune phenomenon. transient nephritis accompanies many plasmodial infections but chronic malarial nephrotic syndrome is specifically associated with quartan malaria. malarial infection ... | 1974 | 4216408 |
| prospects for vaccination against malaria in man. | rodents have been successfully protected against a challenge of viable plasmodium berghei by employing as vaccine: (1) the irradiated blood stages of the same parasite, or (2) the water-insoluble fraction of the blood stages, or (3) irradiated sporozoites; all these vaccines were shown to be stage-specific. a method is outlined for testing in the field, in the absence of any risks, the efficacy of analogous vaccines against falciparum malaria in man. it is emphasized that: (1) the efficacy of th ... | 1974 | 4216411 |
| recent advances in antimalarial chemotherapy and drug resistance. | 1974 | 4217563 | |
| chloroquine-resistant plasmodium falciparum: effect of substrate on chloroquine and amodiaquin accumulation. | glucose stimulates the high-affinity processes of chloroquine and amodiaquin accumulation in owl monkey erythrocytes infected with a chloroquine-susceptible strain of plasmodium falciparum. although these erythrocytes have greater ability to accumulate amodiaquin than chloroquine, glucose has relatively less effect on amodiaquin accumulation than on chloroquine accumulation. in contrast to these findings with chloroquine-susceptible p. falciparum, glucose stimulates amodiaquin but not chloroquin ... | 1974 | 4217585 |
| heterophilic antibodies in relation to malarial infection: population and experimental studies. | 1974 | 4219879 | |
| acute glomerulonephritis complicating plasmodium falciparum infection. | 1974 | 4273621 | |
| [hemoglobinuric bilious fever due to plasmodium falciparum infection. apropos of a fatal case]. | 1974 | 4440962 | |
| schistosomiasis and other human parasitoses of lake lindu in central sulawesi (celebes), indonesia. | 1974 | 4363039 | |
| [invasive malaria with hemoglobinuric bilious fever. apropos of a fatal case]. | 1974 | 4367442 | |
| intraspecific variation in plasmodium falciparum. | 1974 | 4367833 | |
| malaria antibody levels in patients with burkitt's lymphoma. | 1974 | 4367834 | |
| in vitro cultivation of plasmodium falciparum at high parasitemia. | 1974 | 4372903 | |
| a microplate method of enzyme-linked immunosorbent assay and its application to malaria. | a microplate method of enzyme-linked immunosorbent assay is described. this method, which may be of value in the measurement of antibodies in various infectious diseases, is simple, cheap, and easy to carry out on a large scale. for field use, results can be assessed subjectively. the potential of the test is illustrated by a small seroepidemiological study of malaria. | 1974 | 4377238 |
| studies on malaria and responses of anopheles balabacensis balabacensis and anopheles minimus to ddt residual spraying in thailand. i. pre-spraying observations. | 1974 | 4153083 | |
| a critical review of the field application of a mathematical model of malaria eradication. | a malaria control field research trial in northern nigeria was planned with the aid of a computer simulation based on macdonald's mathematical model of malaria epidemiology. antimalaria attack was based on a combination of mass drug administration (chloroquine and pyrimethamine) and ddt house spraying. the observed results were at great variance with the predictions of the model. the causes of these discrepancies included inadequate estimation of the model's basic variables, and overestimation, ... | 1974 | 4156197 |
| response to treatment in man of multi-drug resistant plasmodium falciparum from panama. | 1974 | 4204024 | |
| chemotherapeutic results in a multi-drug resistant strain of plasmodium falciparum malaria from vietnam. | 1974 | 4206160 | |
| acid protease activity in plasmodium falciparum and p. knowlesi and ghosts of their respective host red cells. | 1974 | 4206506 | |
| lymphocyte transformation in human plasmodium falciparum malaria. | 1974 | 4210880 | |
| studies on human malaria in aotus monkeys. iv. development of plasmodium falciparum in two subspecies of aotus trivirgatus. | 1974 | 4132255 | |
| letter: adrenaline provocative test in falciparum malaria. | 1974 | 4132472 | |
| editorial: malaria vaccine: promise or phantom. | 1974 | 4135252 | |
| gametocytes, sporozoites and liver schizonts. | 1974 | 4135674 | |
| some characteristics of the immune response to sporozoites of simian and human malaria. | 1974 | 4138052 | |
| studies on the motility of plasmodium sporozoites. | 1974 | 4138523 | |
| preservation of plasmodium falciparum-infected erythrocytes for in vitro cultures. | 1974 | 4599927 | |
| estimation of antimalarial antibody by radioimmunoassay. | 1974 | 4599928 | |
| the sites of sequestration of the uganda-palo alto strain of plasmodium falciparum-infected red blood cells in the squirrel monkey, samimiri sciureus. | 1974 | 4600380 | |
| malaria symposium--opening address. | 1974 | 4602109 | |
| the occurrence and diagnosis of malaria. | 1974 | 4602110 | |
| recent experiences with severe and cerebral malaria. | 1974 | 4602120 | |
| [malaria]. | 1974 | 4602602 | |
| chemoprophylaxis of malaria for travelers. | 1974 | 4602895 | |
| considerations on the use of sulphones and sulphonamides with a pyrimidine derivative. | 1974 | 4602988 | |
| [malaria is imported; prevention is vitally important for travelers to the tropics]. | 1974 | 4611079 | |
| management of malaria exposure among aircrew members. i. etiology. | 1974 | 4611184 | |
| the blood groups and haemoglobins of the kunama and baria of eritrea, ethiopia. | 1974 | 4611324 | |
| [cerebral tropical malaria with blackwater fever. a current diagnostic and therapeutic problem]. | 1974 | 4612704 | |
| immunization and other prophylactic measures. | 1974 | 4613420 | |
| early diagnosis and clinical picture of malaria. | as a result of extensive travel and temporary residence by people in areas where malaria is endemic, the disease is being reimported into countries from which it has been eradicated. owing to the lack of experience of malaria on the part of present-day physicians and the atypical presentation of some forms of the disease, it is not always recognized, which in the case of falciparum malaria may have grave consequences. in every case of an unexplained fever the possibility of malaria should be tak ... | 1974 | 4613500 |
| [diagnosis and treatment of cerebral malaria in nonendemic areas]. | 1974 | 4613501 | |
| clinical testing of new antimalarial compounds. | more than 200 000 chemical compounds have been screened for antimalarial activity over the past 10 years by the us army antimalarial drug development program. by means of extensive animal testing, 26 of these compounds were selected for clinical study in human subjects volunteering for such trials. of these, 7 have received complete clinical trials and are in various stages of field evaluation, 4 are currently undergoing clinical trial, and 2 are still awaiting testing in volunteer subjects. thu ... | 1974 | 4613503 |
| antifolic combinations in the treatment of malaria. | for the treatment of malaria, combinations of drugs with antifolic action have the great advantage, compared with other drug associations, of synergic action, which increases the effectiveness of the preparation, limits its toxicity, and reduces the risk of resistance. the associations of a sulfonamide (sulfalene, s) with a diaminopyrimidine derivative (pyrimethamine, p, or trimethoprim, t) have given good immediate clinical results. an analysis of the pharmacodynamic and pharmacokinetic charact ... | 1974 | 4613504 |
| treatment of drug-resistant malaria in man. | the progressive spread in asia and south america of falciparum malaria resistant to 4-aminoquinolines, and the focal occurrence in all malarious regions of infections resistant to dihydrofolate dehydrogenase inhibitors such as pyrimethamine and proguanil, make it everywhere necessary to be alert to the failure of accepted curative, prophylactic, or sporontocidal chemotherapeutic agents. resistance to 4-aminoquinolines may be met curatively with courses of treatment lasting 1-14 days, or more, th ... | 1974 | 4613507 |
| mechanisms of acquired immunity and epidemiological patterns of antibody responses in malaria in man. | this paper considers the participation of macrophages, thymus-dependent lymphocytes (t-cells), and thymus-independent lymphocytes (b-cells) in man's immune response to malaria. although phagocytosis by macrophages is an important feature of malaria the full extent of cooperation between these cells and t- and b-cells is not known. evidence that t-cells play an important defensive role is at present unconvincing. b-cells on the other hand function importantly in the synthesis of immunoglobulins a ... | 1974 | 4613508 |
| imported malaria. | there have been 4 waves of imported malaria in the usa. they occurred during the colonization of the country and during the second world war, the un police action in korea, and the viet-nam conflict. the first 3 episodes are briefly described and the data on imported malaria from viet-nam are discussed in detail.endemic malaria is resurgent in many tropical countries and international travel is also on the rise. this increases the likelihood of malaria being imported from an endemic area and int ... | 1974 | 4613510 |
| a malaria model tested in the african savannah. | a new mathematical model of malaria has been developed for comparing the effects of alternative control measures. it describes both the temporal changes of the p. falciparum infection rate and the immunity level of the population as a function of the dynamics and characteristics of the vector populations, which are summarized in the concept of vectorial capacity. a critical vectorial capacity is specified, below which malaria cannot maintain itself at an endemic level. the model has been tested ... | 1974 | 4613512 |
| acetylator phenotype in sulphonamide resistant falciparum malaria. | 1974 | 4614725 | |
| antimalarian precautions for scandinavian tourists. | 1974 | 4615297 | |
| acute falciparum malaria. complications and treatment. | 1974 | 4615381 | |
| experiences with malaria in the early phase of australian army involvement in south vietnam. | 1974 | 4616150 | |
| new perspectives on the chemotherapy of malaria, filariasis, and leprosy. | 1974 | 4616264 | |
| gastrointestinal function, quinine absorption and parasite response in falciparum malaria. | 1974 | 4617310 | |
| recrudescence, poor response or resistance to quinine of falciparum malaria in thailand. | 1974 | 4617311 |