Publications

acute pulmonary insufficiency in falciparum malaria: summary of 12 cases with evidence of disseminated intravascular coagulation.		1974	4603133
preliminary study of wr 33063 in the treatment of falciparum malaria in northeast thailand.		1974	4603134
evaluation of clindamycin in combination with quinine against multidrug-resistant strains of plasmodium falciparum.		1974	4603135
[plasmodium falciparum malaria after extracorporeal circulation].		1974	4603742
malaria in the united kingdom.	over the past decade the united kingdom had the second highest number of cases of imported malaria among european countries. there has been a substantial rise in recorded cases of malaria during the past three years though some of it may be due to improved notification. fatal cases of malaria in visitors to africa have averaged 6.5% of reported infections due to plasmodium falciparum. attacks of vivax malaria may occur several months after travellers return from a malarious country.	1974	4604717
the use of antimalarial drugs.		1974	4605355
[malaria].		1974	4605779
[tropical malaria with cerebral involvement].		1974	4606045
editorial: drugs for prevention of malaria.		1974	4606469
letter: research with plasmodium falciparum in volunteers.		1974	4606749
malaria transmission and fetal growth.	in view of the known relation between infection of the maternal circulation of the placenta with plasmodium falciparum and impaired fetal growth a study was made of the effect on birth weights of a malaria eradication campaign in the british solomon islands. mean birth weights rose substantially within months of starting antimalarial operations. the increases between 1969 and 1971 averaged 252 g in babies of primigravidae and 165 g in all babies. the proportion of babies with birth weights of le ...	1974	4606777
suspected chloroquine-resistant p. falciparum in indonesia: a case report.		1974	4607141
the philippine monkey (macaca philippinensis) as experimental model in the study of plasmodium falciparum.		1974	4607281
some pharmacological aspects of antimalarial drugs.		1974	4607434
fundamental facts concerning malaria in the north-eastern transvaal.		1974	4607552
neonatal malaria due to plasmodium vivax.		1974	4607621
acute renal failure following malaria: treatment by peritoneal dialysis.		1974	4607878
letter: falciparum malaria antigen slides for indirect immuno-fluorescence test made from in vitro cultures.		1974	4608046
letter: sporozoite induced immunity in man against an ethiopian strain of plasmodium falciparum.		1974	4608063
changing patterns of malaria in the united states.		1974	4608177
malaria control in the northern transvaal.		1974	4609013
chloroquine tolerance of ethiopian strains of p. falciparum.		1974	4609061
imported infections. unexplained fever.		1974	4609557
cerebral malaria. on the nature and significance of vascular changes.		1974	4609762
crises in malaria.		1974	4610527
serum folate and folic acid absorption in patients with plasmodium falciparum malaria.		1974	4610778
intestinal parasites and malaria in the poso valley, central sulawesi, indonesia.		1974	4610779
quinine fever in falciparum malaria.		1974	4610781
preliminary report of in vitro and in vivo studies on falciparum malaria in thailand.		1974	4610783
studies on human malaria in aotus monkeys. iv. development of plasmodium falciparum in two subspecies of aotus trivirgatus.		1974	4132255
letter: adrenaline provocative test in falciparum malaria.		1974	4132472
editorial: malaria vaccine: promise or phantom.		1974	4135252
gametocytes, sporozoites and liver schizonts.		1974	4135674
some characteristics of the immune response to sporozoites of simian and human malaria.		1974	4138052
studies on the motility of plasmodium sporozoites.		1974	4138523
studies on malaria and responses of anopheles balabacensis balabacensis and anopheles minimus to ddt residual spraying in thailand. i. pre-spraying observations.		1974	4153083
a critical review of the field application of a mathematical model of malaria eradication.	a malaria control field research trial in northern nigeria was planned with the aid of a computer simulation based on macdonald's mathematical model of malaria epidemiology. antimalaria attack was based on a combination of mass drug administration (chloroquine and pyrimethamine) and ddt house spraying. the observed results were at great variance with the predictions of the model. the causes of these discrepancies included inadequate estimation of the model's basic variables, and overestimation, ...	1974	4156197
immunity and malaria in man.		1974	4212067
the production of antigens by plasmodium falciparum in vitro.		1974	4213471
immunopathology of malaria.	antibodies with different spectra of reactivity are produced during malarial infections and marked changes in igg and igm levels occur. in addition malaria elicits serological changes that are usually associated with connective tissue disease. the excessive anaemia associated with malaria may, in part, be an autoimmune phenomenon. transient nephritis accompanies many plasmodial infections but chronic malarial nephrotic syndrome is specifically associated with quartan malaria. malarial infection ...	1974	4216408
prospects for vaccination against malaria in man.	rodents have been successfully protected against a challenge of viable plasmodium berghei by employing as vaccine: (1) the irradiated blood stages of the same parasite, or (2) the water-insoluble fraction of the blood stages, or (3) irradiated sporozoites; all these vaccines were shown to be stage-specific. a method is outlined for testing in the field, in the absence of any risks, the efficacy of analogous vaccines against falciparum malaria in man. it is emphasized that: (1) the efficacy of th ...	1974	4216411
recent advances in antimalarial chemotherapy and drug resistance.		1974	4217563
chloroquine-resistant plasmodium falciparum: effect of substrate on chloroquine and amodiaquin accumulation.	glucose stimulates the high-affinity processes of chloroquine and amodiaquin accumulation in owl monkey erythrocytes infected with a chloroquine-susceptible strain of plasmodium falciparum. although these erythrocytes have greater ability to accumulate amodiaquin than chloroquine, glucose has relatively less effect on amodiaquin accumulation than on chloroquine accumulation. in contrast to these findings with chloroquine-susceptible p. falciparum, glucose stimulates amodiaquin but not chloroquin ...	1974	4217585
heterophilic antibodies in relation to malarial infection: population and experimental studies.		1974	4219879
acute glomerulonephritis complicating plasmodium falciparum infection.		1974	4273621
response to treatment in man of multi-drug resistant plasmodium falciparum from panama.		1974	4204024
chemotherapeutic results in a multi-drug resistant strain of plasmodium falciparum malaria from vietnam.		1974	4206160
acid protease activity in plasmodium falciparum and p. knowlesi and ghosts of their respective host red cells.		1974	4206506
lymphocyte transformation in human plasmodium falciparum malaria.		1974	4210880
schistosomiasis and other human parasitoses of lake lindu in central sulawesi (celebes), indonesia.		1974	4363039
[invasive malaria with hemoglobinuric bilious fever. apropos of a fatal case].		1974	4367442
intraspecific variation in plasmodium falciparum.		1974	4367833
malaria antibody levels in patients with burkitt's lymphoma.		1974	4367834
in vitro cultivation of plasmodium falciparum at high parasitemia.		1974	4372903
a microplate method of enzyme-linked immunosorbent assay and its application to malaria.	a microplate method of enzyme-linked immunosorbent assay is described. this method, which may be of value in the measurement of antibodies in various infectious diseases, is simple, cheap, and easy to carry out on a large scale. for field use, results can be assessed subjectively. the potential of the test is illustrated by a small seroepidemiological study of malaria.	1974	4377238
[hemoglobinuric bilious fever due to plasmodium falciparum infection. apropos of a fatal case].		1974	4440962
letter: adjuvant treatment of severe falciparum malaria, intravascular coagulation, and heparin.		1975	46084
letter: disseminated intravascular coagulation and severe falciparum malaria.		1975	46976
refeeding-malaria and hyperferraemia.	during the central african (sahelian) drought, attacks of falciparum malaria were common in patients and their relatives shortly after their arrival in a hospital in eastern niger. a prospective study of 72 adult patients not admitted for malaria and 109 accompanying relatives was undertaken to investigate this observation. 23 attacks occurred in patients and 51 in relatives, with a peak frequency five days after arrival. on arrival, parasitaemia was low but reached a maximum by five days. s ...	1975	47080
complement changes and disseminated intravascular coagulation in plasmodium falciparum malaria.	complement activation as shown by increased clearance of radioactive c1q and reduction in serum-c3 level was found in fifteen (83%) of eighteen patients studied during plasmodium falciparum infection. six patients had haemostatic defects suggesting disseminated intravascular coagulation (d.i.c.), and five others had other clinical complications. a correlation was found between reduction of c3 and clinical complications as well as with the degree of anaemia and with thrombocytopenia. moreover, th ...	1975	48001
relation between malaria serum gamma-globulin concentration and the d-xylose absorption test.	d-xylose excretion after a 25 g. oral load was determined in 15 african subjects suffering from malaria. nine of them were re-investigated after the malaria had been or was being treated. malarial parasitaemia and pyrexia did not significantly influence results of the d-xylose test. however, in the untreated subjects, there was a significant inverse correlation between the weight of d-xylose excreted and the serum gamma-globulin concentrations. the observation may have a nutritional importance.	1975	49959
the indirect hemagglutination test for malaria. evaluation of antigens prepared from plasmodium falciparum and plasmodium vivax.	soluble antigens were prepared from plasmodium falciparum and p. vivax and were evaluated in the indirect hemagglutination test. these antigens, attached to aldehyde-fixed type "o" erythrocytes, detected antibodies in more than 91% of infections with the homologous plasmodium species. detection rates in infections caused by the heterologous species ranged from 72% to 76%. positive reactions occurred in less than 2% of sera from persons without malaria infection.	1975	50747
occurrence of s-antigens in serum in plasmodium falciparum infections in man.	gambians with severe plasmodium falciparum infections frequently have malarial s-antigens in their serum or plasma. detection of these with the available antisera which are from immune adults is complicated because there are many different s-antigens and none of the antisera contains antibodies to them all. despite this we found s-antigens in about 60% of a large series of malarious children and demonstrated that this was a considerable underestimate of the true incidence. we also showed that th ...	1975	59433
[chemotherapy in areas of persistent malaria transmission and resistence of plasmodium falciparum to chloroquine in panama].		1975	125597
parasitology survey and seroepidemiology of amoebiasis in south kalimantan (borneo), indonesia.	a parasitology surevy was conducted among inhabitants of 7 villages in 3 regencies in south kalimantan province, indonesia. a total of 2,169 stool specimens, 2,756 blood smears and 1,027 serum specimens were obtained, representing samples from approximately 10%, 12% and 5% of the population, respectively. one to 8 different intestinal parasitic infections were detected in 97% of the people. those parasites most frequently found were trichuris trichiura (83%), ascaris lumbricoides (79%), and hook ...	1975	167454
parasitic infections and the genitourinary tract.		1975	124862
[introduction of malaria into the rsfsr].		1975	126355
chloroquine-resistant malaria in burma.	two field trials to detect chloroquine-resistant malaria were conducted according to who recommendations in a malaria free area near rangoon. peripheral blood smears were examined for asexual forms of p. falciparum on day one through to day seven, on day 14, 21, and 28 after a standard dose of 1500 mg. of chloroquine base. haskins test to detect chloroquine in urine was done on all cases and plasma chloroquine levels were measured in some. out of 105 patients tested ri resistance was detected in ...	1975	128638
[gel diffusion tests in malaria. validity according to different techniques of extracting soluble antigens. sensitivity compared with indirect immunofluorescence].	the value of the gel diffusion test in human malaria varied considerably, depending on the different methods tested to obtain soluble antigens. with one of these antigens, a saponin lysate of plasmodium falciparum infected erythrocytes, the test proved as sensitive and specific as the ifa test with the homologous antigen.	1975	129243
patterns of plasmodium vivax recurrence in a high-incidence coastal area of el salvador, c. a.	during field studies carried out in 1971, 1972 and 1973 in a highly malarious coastal area of el salvador, it was possible to collect information on the patterns of plasmodium vivax parasite occurrence in a large number of infected individuals. in most of the persons who had experienced a malaria attack during the high transmission period in june, july, august and september, renewed activity occurred 5 to 8 months later, during the low transmission season the next year. subsequent activity in th ...	1975	239603
thick-smear plasmodium falciparum antigen from in vitro cultures for the indirect fluorescent antibody test.	an important prerequisite for serological studies is the availability of specific antigens with which a high, consistently reproducible degree of test sensitivity can be obtained. in the present study, thick films of p. falciparum antigen were made from in vitro cultures in order to evaluate this antigen in terms of the sensitivity and reproducibility of the indirect fluorescent antibody test, as compared with an antigen prepared from washed infected erythrocytes of aotus trivirgatus monkeys. th ...	1975	764994
observations on the recent incidence of malaria.		1975	765403
[perinatal transmission of plasmodium falciparum malaria].	two weeks after leaving nigeria for temperate zones and a few hours after giving birth to twins, a nigerian mother suffered an acute attack of malaria due to plasmodium falciparum accompanied by cerebral, renal and hematolgical complications. both infants were apparently healthy at birth, and no parasites were found on peripheral blood smears. both placentas were macroscopically normal. at two months of age the second infant, a boy, developed non-febrile hemolytic anemia due to plasmodium falci ...	1975	766166
treatment of p. falciparum with chloroquine and primaquine in dharmapuri district, tamil nadu.		1975	770319
sero-epidemiological surveillance of disappearing malaria in greece.		1975	772232
[50 cases of acute malaria: symptomatic study, especially cardiac].	the authors have studied 50 records of patients who had presented an acute attack of p. falciparum malaria. both sexes were equally implied. young people were predominant. the distribution of cases was about the same in the whole year. the fever decreases on the second day and increases on the third day (300/0). among the classical signs: relative rarity of hepatomegalia (100/0), splenomegalia (10 0/0), jaundice (140/0), nervous symptoms (100/0). vomiting is rather frequent (30 0/0). from the ca ...	1975	779991
[evaluation of plasmodium falciparum antigen of human origin using indirect immunofluorescence reaction in malaria].	the authors point out the use of p. falciparum antigens from man in the malaria ifa test. in malaria areas it is very easy to find them and although they are "coated" by antibodies they are quite valuable in significant titers. the use of p. falciparum from man is therefore very interesting for malaria diagnosis in non endemic areas and very useful for malaria surveys in endemic areas.	1975	779993
increased frequency of chloroquine resistant p. falciparum on a rubber estate in peninsular malaysia during two years of systematic chloroquine treatment.	chloroquine pressure was applied over a 22 month period on a somewhat isolated, malarious rubber estate by examination of residents at 4-week intervals and treatment of parasitaemias with chloroquine. during this time the monthly attack rate for p. falciparum rose four-fold to an average of nearly 18% per month, while that of p. vivax remained relatively constant at about 8%. eight in vivo chloroquine resistance studies, which allowed both detection of late recrudescing r-i resistance and estima ...	1975	775652
persistence and recurrence of s-antigen in plasmodium falciparum infections in man.	the persistence of heat stable malarial antigens (s-antigens) in the sera of gambian children following treatment for severe plasmodium falciparum infections was investigated. in most cases s-antigens ceased to be demonstrable within 7 days but in some they were detected for several weeks and their persistence correlated with both the density of parasitaemia and the antigen titre observed before treatment. an exponential loss of circulating antigen was, in the majority of individuals, accelerate ...	1975	779155
letter: response of ethiopian strains of plasmodium falciparum to amodiaquine.		1975	779158
the distribution of enzyme variation in populations of plasmodium falciparum in africa.	isolates of plasmodium falciparum collected from the east and west coasts of tropical africa and also from several inland regions have been examined for electrophoretic forms of the enzymes gpi, ldh and 6pgd. variation within and between isolates was found in the parasite forms of all three enzymes. while not disproving the existence of genetic divisions between p. falciparum populations in africa the distribution of this variation provides no evidence for such a hypothesis.	1975	766317
proceedings: invasion of human red cells by plasmodium falciparum in vitro.		1975	766322
coagulation studies in falciparum and vivax malaria.	coagulation factors and serum fibrin degradation products (fdp) were studied in 31 cases of acute falciparum malaria with severe complications, 13 cases without severe complications, and 6 cases of vivax malaria. seven of 13 cases of acute falciparum infection with severe complications died and the coagulation studies were markedly changed and there were high levels of serum fdp. the degree of changes in coagulation and serum fdp varied with the severity of the symptoms and signs and there were ...	1975	769173
jaundice and hepatomegaly in malaria.		1975	770013
response of p. falciparum infection to chloroquine therapy in some parts of tamil nadu and karnataka states.		1975	770318
receptivity to malaria in europe.	experimental work has confirmed the refractoriness of anopheles atroparvus to tropical strains of plasmodium falciparum to which a. labranchiae may also be refractory. this indicates a lower receptivity to malaria in europe than the existing vector densities and increasing number of parasite carriers would suggest.	1975	764992
malaria.		1975	802822
editorial: malaria vaccines on the horizon.		1975	803390
[malarial encephalopathy and disseminated intravascular coagulation (author's transl)].	clinical and anatomical studies of a case of malarial encephalopathy are described in a 51 year old man. in view of the typical symptomatology it was important to ascertain an period even brief of stay in an endemic area. only when this was confirmed the appropriate investigations could be planned (in thic case thick blood drop test) to identify the parassite. the physiopathological mechanisms through which the malarial infection causes the parenchymal lesions are considered. such lesions accord ...	1975	778999
fatal infections in protein-calorie malnourished children with thymolymphatic atrophy.	the clinicopathological features of 25 children who died with protein-calorie malnutrition were studied. all but four subjects were found at necropsy to have nutritional thymectomy and all but 3 died of infectious diseases. the infectious agents were chiefly intracellular micro-organisms including miliary tuberculosis, herpes simplex, varicella, measles, pneumocystis carinii, and plasmodium falciparum. staphylococcal infections, salmonellosis, shigellosis, strongyloidiasis, and hookworm were oth ...	1975	805568
antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria.	this presentation deals with the historical development of the antifolate pyrimidines and related compounds, first as antimalarial substances and later as potent antibacterial agents. it describes the first quantitation of the combined action, through sequential blockade, of the substances with sulfonamides, and outlines the usefulness of the combinations in the therapy of normally sensitive and multiresistant strains of plasmodium falciparum.	1975	805650
parasitological review. experimental monkey hosts for human plasmodia.		1975	807483
the search for new antimalarial drugs.		1975	813015
malaria in studies in vitro. iii: the protein synthesising activity of plasmodium falciparum in vitro after drug treatment in vivo.	aotus trivirgatus monkeys with established infections of plasmodium falciparum were treated orally with either chloroquine or the novel compound 1-amidino-3-(3-chloro-4-cyanophenyl) urea. blood samples were cultured in vitro, 18 hours after treatment, when no morphological abnormalities were apparent. the incorporation of radioactive leucine from the medium by the blood of treated monkeys was compared with that of the undosed control. parasite maturation was also examined. both chloroquine and t ...	1975	808180
protein synthesis in vitro by cryopreserved plasmodium falciparum.	plasmodium falciparum-parasitized erythrocytes obtained from infected owl monkeys (aotus trivirgatus) and stored in the frozen state retain both the capacity to incorporate 14c isoleucine into protein and to infect animals. the cryopreservation method involves the use of glycerol and the reconstitution of isotonicity after thawing. animals have been infected from material held for up to 273 days and protein synthesis has been demonstrated in vitro for up to 180 days after freezing. the specifici ...	1975	811124
invasion of erythrocytes by plasmodium falciparum in vitro.	the erythrocytic stages of plasmodium falciparum from aotus trivirgatus were grown in mill hill medium. significant invasion of erythrocytes was obtained by a subculture technique. this invasion, by parasites grown in aotus erythrocytes, was greater when human erythrocytes were added to the cultures than when parasites were allowed to invade aotus erythrocytes. this difference appeared to be a function of the properties of the erythrocyte and was not serum dependent.	1975	812039
studies on the infectivity of tropical african strains of plasmodium falciparum to some southern european vectors of malaria.	preliminary experiments in garki, nigeria, with a. atroparvus from italy have shown a refractoriness to infection with the local strain of p. falciparum. comparative studies involving a. labranchiae and two strains of a. atroparvus, all from italy, and one local strain of a. gambiae species b, were carried out at kismu, kenya. while oocysts developed in 77% of a. gambiae and, from day 14 onwards, 100% of the oocyst positive mosquitos had sporozoites in the salivary glands, oocysts were seen in o ...	1975	787897
a prospective study of the effects of ultralow volume (ulv) aerial application of malathion on epidemic plasmodium falciparum malaria. iv. epidemiologic aspects.	in the miragoane valley of haiti a consistent pattern in the incidence of plasmodium falciparum malaria over a 10-year period made it possible to predict an annual outbreak and perform a prospective study to test the effects of aerial ultralow volume (ulv) malathion on epidemic levels of this disease. at the end of october 1972, after epidemic levels (100 cases/month/10,000 population) had been reached, spray operations were begun. the first spray cycle produced a sharp and immediate drop in pop ...	1975	1091170
antimalarial effects of clindamycin in man.	clindamycin 450 mg every 8 hours for 3 days cured three non-immune patients of falciparum malaria, although the response was slow. the addition of quinine to this regimen provided an accelerated response and cured 3 of 5 other patients. single doses of clindamycin given daily for 3 days, with or without quinine, cured 1 of 3 patients. gastric intolerance to the drugs, probably accentuated by the clinical condition, was pronounced in some cases, the course of treatment being interrupted in three ...	1975	1091172
letter: prevention of chloroquine-resistant falciparum malaria.		1975	1091190