Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| geosentinel surveillance of illness in returned travelers, 2007-2011. | international travel continues to increase, particularly to asia and africa. clinicians are increasingly likely to be consulted for advice before travel or by ill returned travelers. | 0 | 23552375 |
| larval food quantity affects the capacity of adult mosquitoes to transmit human malaria. | adult traits of holometabolous insects are shaped by conditions experienced during larval development, which might impact interactions between adult insect hosts and parasites. however, the ecology of larval insects that vector disease remains poorly understood. here, we used anopheles stephensi mosquitoes and the human malaria parasite plasmodium falciparum, to investigate whether larval conditions affect the capacity of adult mosquitoes to transmit malaria. we reared larvae in two groups; one ... | 0 | 27412284 |
| causes of non-malarial fever in laos: a prospective study. | because of reductions in the incidence of plasmodium falciparum malaria in laos, identification of the causes of fever in people without malaria, and discussion of the best empirical treatment options, are urgently needed. we aimed to identify the causes of non-malarial acute fever in patients in rural laos. | 0 | 24748368 |
| mosquito biting activity on humans & detection of plasmodium falciparum infection in anopheles stephensi in goa, india. | knowledge of the bionomics of mosquitoes, especially of disease vectors, is essential to plan appropriate vector avoidance and control strategies. information on biting activity of vectors during the night hours in different seasons is important for choosing personal protection measures. this study was carried out to find out the composition of mosquito fauna biting on humans and seasonal biting trends in goa, india. | 0 | 22382193 |
| human antibodies fix complement to inhibit plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria. | antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. we have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasion through c1q fixation and activation of the classical complement pathway. antibody-mediated complement-dependent (ab-c') inhibition was the predominant invasion-inhibitory activit ... | 0 | 25786180 |
| a case report of plasmodium vivax, plasmodium falciparum and dengue co-infection in a 6 months pregnancy. | india being a tropical country, parasitic infections especially with plasmodium species are very common in this region. the present case report is that of plasmodium vivax, plasmodium falciparum and dengue co-infection in a 6 months pregnant lady who was timely diagnosed and appropriately treated followed by a complete recovery along with feto-maternal well-being. | 0 | 24349838 |
| a pfrh5-based vaccine is efficacious against heterologous strain blood-stage plasmodium falciparum infection in aotus monkeys. | antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite plasmodium falciparum. to date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. we recently showed that p. falciparum reticulocyte binding protein homolog 5 (pfrh5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutraliz ... | 0 | 25590760 |
| prediction of outcome of severe falciparum malaria in koraput, odisha, india: a hospital-based study. | infection with plasmodium falciparum, caused 627,000 deaths in 2012 in the world. p. falciparum infection causes myriads of clinical manifestations. exact clinical manifestation resulting in poor prognosis in hyper-endemic epidemiological settings need to be ascertained to save human lives. a hospital-based study was conducted to elucidate the different severe clinical presentations of falciparum malaria and to examine the critical clinical and laboratory parameters on the prognosis of these sev ... | 0 | 25250231 |
| response of malaria vectors to conventional insecticides in the southern districts of odisha state, india. | updating information on response (susceptible / resistant status) of vectors to the insecticides in use is essential to formulate and introduce appropriate resistance management strategy. therefore, a study was undertaken in the 10 southern districts of odisha state, which are endemic for plasmodium falciparum malaria, to determine the insecticide susceptibility/ resistance status of anopheles fluviatilis and an. culicifacies, the vectors of malaria. | 0 | 24718406 |
| neglected plasmodium vivax malaria in northeastern states of india. | the northeastern states of india are co-endemic for plasmodium falciparum and p. vivax malaria. the transmission intensity is low-to-moderate resulting in intermediate to stable malaria. malaria control prioritized p. falciparum being the predominant and life threatening infection (>70%). p. vivax malaria remained somewhat neglected. the present study provides a status report of p. vivax malaria in the northeastern states of india. | 0 | 26139771 |
| malaria transmission in tripura: disease distribution & determinants. | malaria is a major public health problem in tripura and focal disease outbreaks are of frequent occurrence. the state is co-endemic for both plasmodium falciparum and p. vivax and transmission is perennial and persistent. the present study was aimed to review data on disease distribution to prioritize high-risk districts, and to study seasonal prevalence of disease vectors and their bionomical characteristics to help formulate vector species-specific interventions for malaria control. | 0 | 26905237 |
| estimation of vectorial capacity of anopheles minimus theobald & an. fluviatilis james (diptera: culicidae) in a malaria endemic area of odisha state, india. | anopheles minimus and an. fluviatilis were incriminated as the major malaria vectors in keonjhar district of odisha state recently. this study was carried out to elucidate the potential role of these two vector species in transmission of malaria during different seasons, and vectorial capacity of these species was also estimated. | 0 | 25579148 |
| anopheles species composition explains differences in plasmodium transmission in la guajira, northern colombia. | malaria in la guajira, the most northern state of colombia, shows two different epidemiological patterns. malaria is endemic in the municipality of dibulla whereas in riohacha it is characterised by sporadic outbreaks. this study aimed to establish whether differences in transmission patterns could be attributed to different vector species. the most abundant adult female species were anopheles aquasalis, exclusive to riohacha, and anopheles darlingi, restricted to dibulla. anopheles mosquitoes w ... | 0 | 25411002 |
| recent advances in the management of plasmodium knowlesi infection. | plasmodium knowlesi (p. knowlesi) has been detected to be the fifth malarial parasite that can cause malaria in human beings. the parasite is known to commonly infect macaque monkeys. the infection is highly prevalent in south-east asia. it has morphologic similarities to plasmodium malariae and plasmodium falciparum. p. knowlesi is known to replicate every 24 h in the human host and hence, causes "quotidian malaria." it causes a wide spectrum of clinical manifestations and sometimes can cause f ... | 0 | 24754024 |
| investigation of a sudden malaria outbreak in the isolated amazonian village of saul, french guiana, january-april 2009. | malaria is endemic in french guiana. plasmodium falciparum and plasmodium vivax are the predominant species responsible and anopheles darlingi is described as the major vector. in mid-august 2008, an increase in malaria incidence was observed in saül. a retrospective cohort survey was performed. in vitro susceptibility profiles to antimalarials were determined on p. falciparum isolates. collections of mosquitoes were organized. the malaria attack rate reached 70.6/100. the risk of malaria increa ... | 0 | 22492141 |
| malaria situation in india with special reference to tribal areas. | in india, malaria is a major public health problem in states having predominantly tribal population. the objective of this analysis was to find out the incidence of malaria in various states/districts having varied proportions of tribal population using national vector borne disease control programme (nvbdcp) data. | 0 | 26139770 |
| evidence for carry-over effects of predator exposure on pathogen transmission potential. | accumulating evidence indicates that species interactions such as competition and predation can indirectly alter interactions with other community members, including parasites. for example, presence of predators can induce behavioural defences in the prey, resulting in a change in susceptibility to parasites. such predator-induced phenotypic changes may be especially pervasive in prey with discrete larval and adult stages, for which exposure to predators during larval development can have strong ... | 0 | 26674956 |
| analysis of human b-cell responses following chad63-mva msp1 and ama1 immunization and controlled malaria infection. | acquisition of non-sterilizing natural immunity to plasmodium falciparum malaria has been shown in low transmission areas following multiple exposures. however, conflicting data from endemic areas suggest that the parasite may interfere with the induction of effective b-cell responses. to date, the impact of blood-stage parasite exposure on antigen-specific b cells has not been reported following controlled human malaria infection (chmi). here we analysed human b-cell responses in a series of ph ... | 0 | 24303947 |
| vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent plasmodium falciparum infection. | malaria, which is the result of plasmodium falciparum infection, is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. recent phase 3 trials with malaria vaccine candidate rts,s/as01 (rts,s) in children has demonstrated modest efficacy against clinical and severe malaria. rts,s targets the pre-erythrocytic phase of the disease and induces high antibody titers against the p. falciparum circumsporozoite protein (csp) and a moderate cd4(+) t cell re ... | 0 | 24292709 |
| protective cd8+ t-cell immunity to human malaria induced by chimpanzee adenovirus-mva immunisation. | induction of antigen-specific cd8(+) t cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced cd8(+) t cells that correlate with efficacy in humans. here we demonstrate that a replication-deficient chimpanzee adenovirus vector followed by a modified vaccinia virus ankara booster induces exceptionally high frequency t-cell responses (median >2400 sfc/10(6) peripheral blood mononuclear cells) to the liver-stage plasmodium falciparum malaria a ... | 0 | 24284865 |
| evaluation of antiplasmodial activity of extracts and constituents from ampelozizyphus amazonicus. | ampelozizyphus amazonicus ducke, a plant that is widely used by the population of the amazonian region to prevent and treat malaria, was investigated in this work, which describes, for the first time, the antiplasmodial activity of its extracts and associates this activity with its isolated constituents. | 0 | 26664012 |
| a tetracycline-repressible transactivator system to study essential genes in malaria parasites. | a major obstacle in analyzing gene function in apicomplexan parasites is the absence of a practical regulatable expression system. here, we identified functional transcriptional activation domains within apicomplexan ap2 (apiap2) family transcription factors. these apiap2 transactivation domains were validated in blood-, liver-, and mosquito-stage parasites and used to create a robust conditional expression system for stage-specific, tetracycline-dependent gene regulation in toxoplasma gondii, p ... | 0 | 23245327 |
| hiv nonnucleoside reverse transcriptase inhibitors and trimethoprim-sulfamethoxazole inhibit plasmodium liver stages. | although nonnucleoside reverse transcriptase inhibitors (nnrtis) are usually part of first-line treatment regimens for human immunodeficiency virus (hiv), their activity on plasmodium liver stages remains unexplored. additionally, trimethoprim-sulfamethoxazole (tmp-smx), used for opportunistic infection prophylaxis in hiv-exposed infants and hiv-infected patients, reduces clinical episodes of malaria; however, tmp-smx effect on plasmodium liver stages requires further study. | 0 | 23125449 |
| quinolone-3-diarylethers: a new class of antimalarial drug. | the goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of the disease. the 4(1h)-quinolone-3-diarylethers are selective potent inhibitors of the parasite's mitochondrial cytochrome bc1 complex. these compounds are highly active against the human malaria parasites plasmodium falciparum and plasmodium vivax. they target both the liver and blood stages of the parasite a ... | 0 | 23515079 |
| human igf1 extends lifespan and enhances resistance to plasmodium falciparum infection in the malaria vector anopheles stephensi. | the highly conserved insulin/insulin-like growth factor (igf) signaling (iis) pathway regulates metabolism, development, lifespan and immunity across a wide range of organisms. previous studies have shown that human insulin ingested in the blood meal can activate mosquito iis, resulting in attenuated lifespan and increased malaria parasite infection. because human igf1 is present at higher concentrations in blood than insulin and is functionally linked with lifespan and immune processes, we pred ... | 0 | 23255191 |
| pfe0565w, a plasmodium falciparum protein expressed in salivary gland sporozoites. | because malaria is still a significant problem worldwide, additional control methods need to be developed. the plasmodium sporozoite is a good target for control measures because it displays dual infectivity for both mosquito and vertebrate host tissues. the plasmodium falciparum gene, pfe0565w, was chosen as a candidate for study based on data from plasmodb, the plasmodium database, indicating that it is expressed both at the transcriptional and protein levels in sporozoites, likely encodes a p ... | 0 | 22665598 |
| absence of asymptomatic malaria infection in endemic area of bashagard district, hormozgan province, iran. | a successful malaria elimination program calls for enough attention to parasite carriers, especially asymptomatic malaria, as well as the diagnosis and treatment of clinical cases. asymptomatic malaria is an infection that patients do not show any symptom; thus, these patients play critical role in the concept of an elimination program. the current investigation was conducted to evaluate the presence of these cases in bashagard district, formerly a high malaria transmission area in hormozgan pro ... | 0 | 23133470 |
| quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry. | there is an important role for in vitro assays to better understand the initial steps of malaria infection. in this section, we describe both microscopy-based and flow cytometry-based sporozoite invasion, migration and development assays with the rodent malaria parasites, plasmodium berghei and plasmodium yoelii, and the human malaria parasite, plasmodium falciparum. | 0 | 22990793 |
| real-time quantitative reverse transcription pcr for monitoring of blood-stage plasmodium falciparum infections in malaria human challenge trials. | to detect pre-patent parasitemia, we developed a real-time quantitative reverse transcription-polymerase chain reaction (qrt-pcr) for the asexual 18s ribosomal rna (rrnas) of plasmodium falciparum. total nucleic acids extracted from whole blood were combined with control rna and tested by qrt-pcr. the assay quantified > 98.7% of parasite-containing samples to ±0.5 log(10) parasites/ml of the nominal value without false positives. the analytical sensitivity was ≥ 20 parasites/ml. the coefficient ... | 0 | 22403305 |
| antibody and t-cell responses associated with experimental human malaria infection or vaccination show limited relationships. | this study examined specific antibody and t-cell responses associated with experimental malaria infection or malaria vaccination, in malaria-naive human volunteers within phase i/iia vaccine trials, with a view to investigating inter-relationships between these types of response. malaria infection was via five bites of plasmodium falciparum-infected mosquitoes, with individuals reaching patent infection by 11-12 days, having harboured four or five blood-stage cycles before drug clearance. infect ... | 0 | 25471322 |
| the remarkable journey of adaptation of the plasmodium falciparum malaria parasite to new world anopheline mosquitoes. | plasmodium falciparum originated in africa, dispersed around the world as a result of human migration and had to adapt to several different indigenous anopheline mosquitoes. anophelines from the new world are evolutionary distant form african ones and this probably resulted in a more stringent selection of plasmodium as it adapted to these vectors. it is thought that plasmodium has been genetically selected by some anopheline species through unknown mechanisms. the mosquito immune system can gre ... | 0 | 25185006 |
| evidence of an increased incidence of day 3 parasitaemia in suriname: an indicator of the emerging resistance of plasmodium falciparum to artemether. | the emerging resistance to artemisinin derivatives that has been reported in south-east asia led us to assess the efficacy of artemether-lumefantrine as the first line therapy for uncomplicated plasmodium falciparum infections in suriname. this drug assessment was performed according to the recommendations of the world health organization in 2011. the decreasing number of malaria cases in suriname, which are currently limited to migrating populations and gold miners, precludes any conclusions on ... | 0 | 24402149 |
| cross-reactive anti-pfclag9 antibodies in the sera of asymptomatic parasite carriers of plasmodium vivax. | the pfclag9 has been extensively studied because their immunogenicity. thereby, the gene product is important for therapeutics interventions and a potential vaccine candidate. antibodies against synthetic peptides corresponding to selected sequences of the plasmodium falciparum antigen pfclag9 were found in sera of falciparum malaria patients from rondônia, in the brazilian amazon. much higher antibody titres were found in semi-immune and immune asymptomatic parasite carriers than in subjects su ... | 0 | 23440122 |
| [anopheles (díptera: culicidae) vectors of malaria in puerto carreño municipality, vichada, colombia]. | the study of the biological aspects of anopheles spp., strengthens the entomological surveillance. | 0 | 23235809 |
| collapse of anopheles darlingi populations in suriname after introduction of insecticide-treated nets (itns); malaria down to near elimination level. | a longitudinal study of malaria vectors was carried out in three villages in suriname between 2006 and 2010. during 13,392 man hours of collections, 3,180 mosquitoes were collected, of which 33.7% were anophelines. of these, anopheles darlingi accounted for 88.1%, and an. nuneztovari accounted for 11.1%. the highest mean an. darlingi human biting rate (hbr) observed per survey was 1.43 bites/man per hour outdoor and 1.09 bites/man per hour indoor; 2 an. darlingi of the 683 tested were infected w ... | 0 | 22492150 |
| geographic distribution, evolution, and disease importance of species within the neotropical anopheles albitarsis group (diptera, culicidae). | the anopheles albitarsis group of mosquitoes comprises eight recognized species and one mitochondrial lineage. our knowledge of malaria vectorial importance and the distribution and evolution of these taxa is incomplete. we constructed ecological niche models (enms) for these taxa and used hypothesized phylogenetic relationships and enms to investigate environmental and ecological divergence associated with speciation events. two major clades were identified, one north (clade 1) and one south (c ... | 0 | 24820570 |
| insecticide-treated plastic sheeting for emergency malaria prevention and shelter among displaced populations: an observational cohort study in a refugee setting in sierra leone. | a double-blind phase iii malaria prevention trial was conducted in two refugee camps using pre-manufactured insecticide-treated plastic sheeting (itps) or untreated polyethylene sheeting (ups) randomly deployed to defined sectors of each camp. in largo camp the itps or ups was attached to inner walls and ceilings of shelters, whereas in tobanda the itps or ups was used to line only the ceiling and roof. in largo the plasmodium falciparum incidence rate in children up to 3 years of age who were c ... | 0 | 22855753 |
| genetic diversity of plasmodium falciparum merozoite surface protein-1 block 2 in sites of contrasting altitudes and malaria endemicities in the mount cameroon region. | the present study analyzed the relationship between the genetic diversity of plasmodium falciparum and parasitologic/entomologic indices in the mount cameroon region by using merozoite surface protein 1 as a genetic marker. blood samples were collected from asymptomatic children from three altitude zones (high, intermediate, and low). parasitologic and entomologic indices were determined by microscopy and landing catch mosquito collection/circumsporozoite protein-enzyme-linked immunosorbent assa ... | 0 | 22556072 |
| in vitro and in vivo antimalarial activity and cytotoxicity of extracts, fractions and a substance isolated from the amazonian plant tachia grandiflora (gentianaceae). | tachia sp. are used as antimalarials in the amazon region and in vivo antimalarial activity of a tachia sp. has been previously reported. tachia grandiflora maguire and weaver is an amazonian antimalarial plant and herein its cytotoxicity and antimalarial activity were investigated. spectral analysis of the tetraoxygenated xanthone decussatin and the iridoid aglyone amplexine isolated, respectively, from the chloroform fractions of root methanol and leaf ethanol extracts was performed. in vitro ... | 0 | 23827996 |
| characterization of the target of ivermectin, the glutamate-gated chloride channel, from anopheles gambiae. | the use of insecticide-treated nets and indoor residual insecticides targeting adult mosquito vectors is a key element in malaria control programs. however, mosquito resistance to the insecticides used in these applications threatens malaria control efforts. recently, the mass drug administration of ivermectin (ivm) has been shown to kill anopheles gambiae mosquitoes and disrupt plasmodium falciparum transmission in the field. we cloned the molecular target of ivm from a. gambiae, the glutamate- ... | 0 | 25994631 |
| monitoring parasite diversity for malaria elimination in sub-saharan africa. | the african continent continues to bear the greatest burden of malaria and the greatest diversity of parasites, mosquito vectors, and human victims. the evolutionary plasticity of malaria parasites and their vectors is a major obstacle to eliminating the disease. of current concern is the recently reported emergence of resistance to the front-line drug, artemisinin, in south-east asia in plasmodium falciparum, which calls for preemptive surveillance of the african parasite population for genetic ... | 0 | 25214619 |
| malaria parasitaemia among blood donors in ilorin, nigeria. | the prevalence of malaria parasitaemia among blood donors in ilorin has not been documented. in this study, we determined the prevalence of malaria parasitaemia among blood donors in ilorin, as well as, the sociodemographic and other factors associated with it. | 0 | 25722845 |
| transdermal diagnosis of malaria using vapor nanobubbles. | a fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. we designed a device for rapid (20-second) noninvasive diagnosis of plasmodium falciparum infection in a malaria patient without drawing blood or using any reagent. this method uses transdermal optical excitation and acoustic detection of vapor nanob ... | 0 | 26079141 |
| supergenomic network compression and the discovery of exp1 as a glutathione transferase inhibited by artesunate. | a central problem in biology is to identify gene function. one approach is to infer function in large supergenomic networks of interactions and ancestral relationships among genes; however, their analysis can be computationally prohibitive. we show here that these biological networks are compressible. they can be shrunk dramatically by eliminating redundant evolutionary relationships, and this process is efficient because in these networks the number of compressible elements rises linearly rathe ... | 0 | 25126794 |
| species composition and temporal distribution of mosquito populations in ibadan, southwestern nigeria. | nigeria has a high burden of vector borne diseases such as malaria and lymphatic filariasis (lf). this study aimed to determine the species composition of mosquitoes in ibadan, southwest nigeria as well as determine their role in malaria and lf transmission. adult mosquitoes were collected by pyrethrum spray catch (psc) and identified and graded according to their abdominal conditions. the mosquitoes were dissected to determine the parity status and to check for microfilariae of wuchereria bancr ... | 0 | 25520960 |
| insecticide exposure impacts vector-parasite interactions in insecticide-resistant malaria vectors. | currently, there is a strong trend towards increasing insecticide-based vector control coverage in malaria endemic countries. the ecological consequence of insecticide applications has been mainly studied regarding the selection of resistance mechanisms; however, little is known about their impact on vector competence in mosquitoes responsible for malaria transmission. as they have limited toxicity to mosquitoes owing to the selection of resistance mechanisms, insecticides may also interact with ... | 0 | 24850924 |
| climate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios. | despite the dependence of mosquito population dynamics on environmental conditions, the associated impact of climate and climate change on present and future malaria remains an area of ongoing debate and uncertainty. here, we develop a novel integration of mosquito, transmission and economic modelling to assess whether the cost-effectiveness of indoor residual spraying (irs) and long-lasting insecticidal nets (llins) against plasmodium falciparum transmission by anopheles gambiae s.s. mosquitoes ... | 0 | 25688017 |
| measuring changes in plasmodium falciparum transmission: precision, accuracy and costs of metrics. | as malaria declines in parts of africa and elsewhere, and as more countries move towards elimination, it is necessary to robustly evaluate the effect of interventions and control programmes on malaria transmission. to help guide the appropriate design of trials to evaluate transmission-reducing interventions, we review 11 metrics of malaria transmission, discussing their accuracy, precision, collection methods and costs and presenting an overall critique. we also review the nonlinear scaling rel ... | 0 | 24480314 |
| malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. | malaria is a mosquito-borne disease caused by parasites of the obligate intracellular apicomplexa phylum the most deadly of which, plasmodium falciparum, prevails in africa. malaria imposes a huge health burden on the world's most vulnerable populations, claiming the lives of nearly one million children and pregnant women each year. although there is keen interest in eradicating malaria, we do not yet have the necessary tools to meet this challenge, including an effective malaria vaccine and ade ... | 0 | 24655294 |
| potential risk of induced malaria by blood transfusion in south-eastern nigeria. | induced malaria by blood transfusion is a potential health hazard but is often neglected in many malaria endemic areas. standard parasitological technique was used to determine the prevalence of malaria among blood donors in the south-eastern nigeria. of the total 325 blood donors (310 males and 15 females) screened, 133 (40.9%, ci 95%: 35.6-46.2%) were infected with malaria parasite, 78 (58.6%) had 1-10 parasites per 100 thick film fields ('+' or 4-40 parasites per mm3) while 55 (41.4%) had 11- ... | 0 | 19529802 |
| plasmodium falciparum, anaemia and cognitive and educational performance among school children in an area of moderate malaria transmission: baseline results of a cluster randomized trial on the coast of kenya. | studies have typically investigated health and educational consequences of malaria among school-aged children in areas of high malaria transmission, but few have investigated these issues in moderate transmission settings. this study investigates the patterns of and risks for plasmodium falciparum and anaemia and their association with cognitive and education outcomes on the kenyan coast, an area of moderate malaria transmission. | 0 | 22950512 |
| sickle cell trait protects against plasmodium falciparum infection. | although sickle cell trait protects against severe disease due to plasmodium falciparum, it has not been clear whether sickle trait also protects against asymptomatic infection (parasitemia). to address this question, the authors identified 171 persistently smear-negative children and 450 asymptomatic persistently smear-positive children in bancoumana, mali (june 1996 to june 1998). they then followed both groups for 2 years using a cohort-based strategy. among the 171 children with persistently ... | 0 | 23035141 |
| genetic diversity and complexity of plasmodium falciparum infections in lagos, nigeria. | to analyse the genetic diversity of plasmodium falciparum (p. falciparum) using msp-1 and msp-2 as antigenic markers. | 0 | 25183154 |
| molecular epidemiology of plasmodium falciparum malaria outbreak, tumbes, peru, 2010-2012. | during 2010-2012, an outbreak of 210 cases of malaria occurred in tumbes, in the northern coast of peru, where no plasmodium falciparum malaria case had been reported since 2006. to identify the source of the parasite causing this outbreak, we conducted a molecular epidemiology investigation. microsatellite typing showed an identical genotype in all 54 available isolates. this genotype was also identical to that of parasites isolated in 2010 in the loreto region of the peruvian amazon and closel ... | 0 | 25897626 |
| chloroquine-resistant malaria in travelers returning from haiti after 2010 earthquake. | we investigated chloroquine sensitivity to plasmodium falciparum in travelers returning to france and canada from haiti during a 23-year period. two of 19 isolates obtained after the 2010 earthquake showed mixed pfcrt 76k+t genotype and high 50% inhibitory concentration. physicians treating malaria acquired in haiti should be aware of possible chloroquine resistance. | 0 | 22840888 |
| artemisinin-resistant plasmodium falciparum malaria. | for more than five decades, southeast asia (sea) has been fertile ground for the emergence of drug-resistant plasmodium falciparum malaria. after generating parasites resistant to chloroquine, sulfadoxine, pyrimethamine, quinine, and mefloquine, this region has now spawned parasites resistant to artemisinins, the world's most potent antimalarial drugs. in areas where artemisinin resistance is prevalent, artemisinin combination therapies (acts)-the first-line treatments for malaria-are failing fa ... | 0 | 27337450 |
| distribution of drug resistance genotypes in plasmodium falciparum in an area of limited parasite diversity in saudi arabia. | two hundred and three plasmodium falciparum isolates from jazan area, southwest saudi arabia, were typed for pfcrt, pfmdr1, dhps, and dhfr mutations associated with resistance to chloroquine, mefloquine, halofantrine, artemisinin, sulfadoxine-pyrimethamine, and the neutral polymorphic gene pfg377. a large proportion (33%) of isolates harbored double mutant dhfr genotype (51i,59c,108n). however, only one isolate contained mutation dhps-437g. for pfcrt, almost all examined isolates (163; 99%) harb ... | 0 | 22556074 |
| the cultivation of malarial plasmodia (plasmodium vivax and plasmodium falciparum) in vitro. | the asexual cycle of plasmodium vivax and plasmodium falciparum has been cultivated in vitro in human blood. the parasites have been grown also in red blood cells in the presence of locke's solution, free of calcium chlorid and in the presence of ascitic fluid. the parasites grow within red blood cells and there is no evidence that they can be grown outside of these cells. the parasites are destroyed in a very few minutes in vitro by normal human serum or by all modifications of serum that we ha ... | 1912 | 19867597 |
| experiments on the development of malaria parasites in three american species of anopheles. | since a knowledge of the susceptibility of any species of anopheles to infection with malaria parasites is of great importance in determining its part in the transmission of malaria, the experiments reported here were undertaken, and included the three most prevalent species of this genus occurring in the united states. as a result of these experiments anopheles punctipennis is shown to be an efficient host of the organisms of tertian and estivo-autumnal malaria, anopheles crucians of estivo-aut ... | 1916 | 19868018 |
| experimental inoculation of malaria by means of anopheles ludlowi. | three persons were experimentally inoculated with malaria by means of anopheles ludlowi reared from larvae and infected with a pure strain of subtertian plasmodium (plasmodium falciparum), thus proving that there exists no mechanical impediment or obstacle to the free exit of sporozoites from the salivary ducts or proboscis. in the dissection of infected mosquitoes there were no evidences of degenerated zygotes. sporozoites appeared promptly in the salivary glands (9 to 12 days). inoculation occ ... | 1920 | 19868447 |
| the relative numbers of male and female gametocytes in human malaria (plasmodium vivax, plasmodium falciparum and plasmodium malariae) and hoemoproteus in birds. | 1927 | 19985510 | |
| the relative numbers of male and female gametocytes in human malaria (plasmodium vivax, plasmodium falciparum and plasmodium malariæ) and hœmoproteus in birds. | 1927 | 20909907 | |
| complement fixation in human malaria with an antigen prepared from the monkey parasite plasmodium knowlesi. | in the studies of complement fixation described in this paper, the antigens were prepared from (a) normal monkey red cells, (b) parasitized red cells of monkeys dying with plasmodium knowlesi infection, (c) the spleens of monkeys dying with plasmodium knowlesi infection; the sera came from (a) normal human beings, (b) patients with syphilis, (c) patients with paresis who were receiving malaria therapy with plasmodium knowlesi, plasmodium vivax, or plasmodium falciparum, and (d) patients with mal ... | 1939 | 19870853 |
| malaria due to plasmodium falciparum in new york. | 1945 | 21003953 | |
| on the heterologous value of acquired immunity to plasmodium falciparum. | 1945 | 21016052 | |
| dividing forms of plasmodium falciparum in the peripheral blood of africans. | 1945 | 20293960 | |
| the effect of anti-malarial drugs on plasmodium falciparum (new guinea strains) developing in vitro. | 1946 | 20275227 | |
| plasmodium falciparum malaria; the coronary and myocardial lesions observed at autopsy in two cases of acute fulminating p. falciparum infection. | 1946 | 21019991 | |
| the behaviour of new guinea strains of plasmodium falciparum and plasmodium vivax when cultivated in vitro. | 1946 | 20994424 | |
| estivoautumnal (plasmodium falciparum) malaria; a survey of four hundred and ninety-three cases of infection with plasmodium falciparum in children. | 1946 | 20996441 | |
| a study of a strain of plasmodium falciparum indigenous to the belgian congo. | 1947 | 18861564 | |
| on the control of malaria in freetown, sierra leone; plasmodium falciparum and anopheles gambiae in relation to malaria occurring in infants. | 1947 | 18902137 | |
| serological tests for syphilis in treated plasmodium falciparum malaria. | 1947 | 20270459 | |
| the gametocytocidal action of paludrine upon infections of plasmodium falciparum. | 1948 | 18907589 | |
| infection of reticulocytes by plasmodium falciparum and plasmodium malariae in hyperendemic indigenous malaria. | 1948 | 18915551 | |
| a malarial death; case report of acute plasmodium falciparum para-sitization. | 1948 | 18858261 | |
| family traits and traitors. | 1948 | 18858262 | |
| studies on the chemotherapy of the human malarias; method for the quantitative assay of suppressive antimalarial action in falciparum malaria. | 1948 | 18860183 | |
| [experimental infection compared to a. moucheti evans and a. gambiae giles pa plasmodium falciparum]. | 1949 | 15398009 | |
| the action of antimalarial drugs in mosquitoes infected with plasmodium falciparum. | 1949 | 18110329 | |
| studies on a west african strain of plasmodium falciparum; the efficacy of paludrine as a prophylactic agent. | 1949 | 18117638 | |
| observations on the action of quinine, atebrin and plasmoquine on the gametocytes of plasmodium falciparum. | 1949 | 18118367 | |
| studies on a west african strain of plasmodium falciparum; the efficacy of paludrine as a therapeutic agent. | 1949 | 18118368 | |
| acquired resistance to proguanil in plasmodium falciparum. | 1949 | 18137351 | |
| experimental cortical necrosis of adrenal gland in the monkey in diphtheria and in malaria; with observations on a fatal human infection with plasmodium falciparum. | 1949 | 18138914 | |
| the pre-erythrocytic stage of plasmodium falciparum; a preliminary note. | 1949 | 15393036 | |
| on the control of malaria in freetown, sierra leone; control methods and the effects upon the transmission of plasmodium falciparum resulting from the reduced abundance of anopheles gambiae. | 1949 | 15393585 | |
| the diagnostic value of bone marrow biopsy in malaria caused by plasmodium falciparum. | 1949 | 15405632 | |
| chloroquine, proguanil, mepacrine and quinine in the treatment of malaria caused by plasmodium falciparum. | 1949 | 15405641 | |
| the experimental transmission of plasmodium falciparum by anopheles albimanus. | 1949 | 15407896 | |
| [mexican strains of plasmodium falciparum in malariotherapy]. | 1950 | 13047930 | |
| the comparative susceptibility of anopheles albimanus and anopheles quadrimaculatus to a south carolina strain of plasmodium falciparum. | 1950 | 14774536 | |
| [therapeutic malaria with plasmodium falciparum in negroes and mulattoes]. | 1950 | 14781093 | |
| the comparative susceptibility of anopheles quadrimaculatus and two strains of anopheles albimanus to a panama strain of plasmodium falciparum. | 1950 | 14804094 | |
| the pre-erythrocytic stage of plasmodium falciparum. | 1951 | 14817818 | |
| a study of gametocytes in a west african strain of plasmodium falciparum. | 1951 | 14817819 | |
| the duration of untreated or inadequately treated plasmodium falciparum infections in the human host. | 1951 | 14908561 | |
| observations on a gametocyteless strain of plasmodium falciparum. | 1951 | 14908562 | |
| [nosographic data on experimental infection with plasmodium falciparum]. | 1951 | 13028083 | |
| the treatment of plasmodium falciparum malaria with a single dose antimalarial; a preliminary report of the use of hydroxychloroquine, 7-chloro-4(4-(n-ethyl-n-b-hydroxyethylamino)-1-methylbutylamino)-quinoline diphosphate. | 1952 | 24541823 |