Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [suppressive effect of 3 combinations of antimalarials against plasmodium cynomolgi]. | 1987 | 3450444 | |
| [in vitro cultivation of plasmodium cynomolgi bastianelli in hepatocytes of the macaca rhesus]. | primary cultures of rhesus monkey were infected with sporozoites of p. c. bastianelli. despite a high level of contamination, two schizonts were seen at days 6 and 11. | 1987 | 3566091 |
| experimental studies on the effect of artesunate sustained released tablet on plasmodium cynomolgi. | 1987 | 3449712 | |
| attenuation of the virulence of the m strain of plasmodium cynomolgi during prolonged multiplication in splenectomized rhesus monkeys. | the primary data in this report showed that prolonged multiplication of the m strain of plasmodium cynomolgi in splenectomized rhesus monkeys led frequently to emergence of parasites whose virulence for monkeys with intact spleens was markedly attenuated while that for splenectomized monkeys was unimpaired. expressions of attenuation regularly included reductions in the height of the peak parasitemia and in some instances failure to induce infection with inocula 1,000-fold those infective for sp ... | 1987 | 3688305 |
| modifications of primaquine as antimalarials. 4. 5-alkoxy derivatives of primaquine. | thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (plasmodium berghei, mouse) and tissue schizonticides (plasmodium cynomolgi, monkey). several of these compounds were extremely active in both screens. such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the various relapsing and nonrelapsing malarias. | 1987 | 3599024 |
| the circumsporozoite gene of the plasmodium cynomolgi complex. | an analysis of the circumsporozoite (cs) genes of six closely related plasmodia is presented. like other plasmodial antigens, the cs protein contains tandem repeats flanked by conventional nonrepeated sequences. our analysis shows that the repeats, which encode the immunodominant epitope of the cs protein, diverge more rapidly than the remainder of the gene, and that the maintenance and evolution of the repeats cannot be explained as the result of selection at the protein level. we argue that a ... | 1987 | 3802196 |
| relapse patterns in plasmodium cynomolgi malaria. | 1987 | 3661833 | |
| further studies on the antigenic diversity of the circumsporozoite proteins of the plasmodium cynomolgi complex. | the circumsporozoite (cs) proteins of strains of the plasmodium cynomolgi complex have been examined using antisporozoite monoclonal antibodies (mab) in various immunologic assays. we found extensive antigenic diversity in the repeating immunodominant epitope of the cs proteins of the various strains. based on the antigenicity and the electrophoretic mobility of their cs protein, the 11 strains that we examined can be placed in 7 distinct groups. our data also indicate homology between the immun ... | 1986 | 2422969 |
| recombinant human gamma interferon inhibits simian malaria. | prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with plasmodium cynomolgi b sporozoites in rhesus monkeys. treatment with lower doses partially suppressed this infection. prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development. | 1986 | 3091507 |
| sequential changes in ifa titres and protein fractions of sera from plasmodium cynomolgi b infected simian hosts. | 1986 | 3570370 | |
| [on the residual activity of pyronaridine against plasmodium cynomolgi in rhesus monkeys]. | 1986 | 3769158 | |
| correlation of survival rates of anopheles dirus a (diptera: culicidae) with different infection densities of plasmodium cynomolgi. | the survival rates are described for 36 paired replicates of anopheles dirus a mosquitos that had been allowed to engorge themselves on rhesus monkeys that were either infected or non-infected with plasmodium cynomolgi. the survival rates of infected mosquitos with a mean number of oocysts less than 10 did not differ significantly from those that were non-infected; however, there was a significant difference in the survival rates of non-infected groups and those with a mean number of oocysts in ... | 1986 | 3493859 |
| 4,5-disubstituted primaquine analogues as potential antimalarial agents. | three 4,5-disubstituted primaquine analogues were synthesized and evaluated for radical curative activity against plasmodium cynomolgi in rhesus monkeys. one of the compounds showed moderate activity; however, none of the three compounds were as active as the lead compounds 5-methoxy-4-methylprimaquine and 4-(methoxy-methyl)-5-[m-(trifluoromethyl)phenoxy]primaquine. | 1986 | 3746825 |
| [further studies on the relapse of plasmodium cynomolgi in rhesus monkeys]. | 1986 | 3769157 | |
| genetic selection of a plasmodium-refractory strain of the malaria vector anopheles gambiae. | the anopheline mosquito is the target in most malaria control programs, primarily through the use of residual insecticides. a mosquito was studied that is refractory to most species of malaria through a genetically controlled mechanism. a strain of anopheles gambiae, which was selected for complete refractoriness to the simian malaria parasite plasmodium cynomolgi, also has varying degrees of refractoriness to most other malaria species examined, including the human parasites p. falciparum, p. o ... | 1986 | 3532325 |
| compatibility of relapse patterns of plasmodium cynomolgi infections in rhesus monkeys with continuous cyclical development and hypnozoite concepts of relapse. | this report encompasses the results of two studies on the relapse patterns of infections with the b strain of plasmodium cynomolgi treated repetitively with chloroquine. one study of sizeable dimensions dealt primarily with relapses that occurred within 120 days of onset of patency in infections induced with inocula of 10(5) to 7 x 10(6) sporozoites. the second study, of more limited dimensions, dealt with relapses that occurred over a 689-day period after inoculation with 5 x 10(0) to 5 x 10(6) ... | 1986 | 3538919 |
| evolutionary profile of the circumsporozoite gene of the plasmodium cynomolgi complex. | the circumsporozoite genes and flanking sequences of the ceylon, gombak, london, nih and mulligan strains of the plasmodium cynomolgi complex were isolated by molecular cloning and compared. about 11,000 bases of the gombak clone were mapped in detail and found to have their exact counterparts in all the other strains. in contrast the epitope-encoding region, a 600-base sequence consisting of short tandem repeats, exhibited no homology with any of the other clones. these findings show that diffe ... | 1986 | 3735434 |
| [action of nitroquine on tissue schizonts of plasmodium cynomolgi]. | 1986 | 2945393 | |
| enhancement of the curative activity of primaquine by concomitant administration of mirincamycin. | mirincamycin, a lincomycin derivative with unequivocal but limited activity against the pre-erythrocytic and persisting exoerythrocytic stages of plasmodium cynomolgi, has been evaluated for capacity to enhance the radical curative potential of the conventional primaquine-chloroquine combination. established infections with sporozoites of the above plasmodium in rhesus monkeys served this evaluation. the results showed that the dose of primaquine required for cure of 50% of active infections was ... | 1985 | 3885847 |
| circumsporozoite protein of plasmodium vivax: gene cloning and characterization of the immunodominant epitope. | the gene encoding the circumsporozoite (cs) protein of the human malaria parasite plasmodium vivax has been cloned. the deduced sequence of the protein consists of 373 amino acids with a central region of 19 tandem repeats of the nonapeptide asp-arg-ala-asp/ala-gly-gln-pro-ala-gly. a synthetic 18-amino acid peptide containing two tandem repeats binds to a monoclonal antibody directed to the cs protein of plasmodium vivax and inhibits the interaction of this antibody with the native protein in sp ... | 1985 | 2414847 |
| observations on early and late post-sporozoite tissue stages in primate malaria. iii. further attempts to find early forms and to correlate hypnozoites with growing exo-erythrocytic schizonts and parasitaemic relapses in plasmodium cynomolgi bastianellii infections. | rhesus monkeys were heavily infected with sporozoites of plasmodium cynomolgi bastianellii in an attempt to demonstrate the site of invasion of sporozoites into tissue cells and their growth there. further attempts were made to correlate the appearance and loss of hypnozoites with parasitaemic relapses. hypnozoites were demonstrated and once again shown to decrease in numbers over 229 days during which time the infection showed parasitaemic relapses. liver biopsies taken at two-day intervals for ... | 1985 | 4002302 |
| antimalarial activities and subacute toxicity of rc-12, a 4-amino-substituted pyrocatechol. | rc-12 [1,2-dimethoxy-4-(bis-diethylaminoethyl)-amino-5-bromobenzene] was evaluated for prophylactic, radical curative, and suppressive activities against infections with plasmodium cynomolgi and subacute toxicity in rhesus monkeys. applied as a prophylactic agent, rc-12, administered in doses of 6.25 to 25.0 mg/kg daily throughout the incubation period, provided near-complete to complete protection against 10(5) to 10(6) times the minimum infective dose of sporozoites. applied as a suppressive a ... | 1985 | 4091527 |
| antigenic diversity of the circumsporozoite proteins in the plasmodium cynomolgi complex. | antigenic diversity was observed in the circumsporozoite (cs) proteins of five of the six plasmodium cynomolgi isolates (nih, mulligan, london, gombak, ceylon, ro) that we examined. monoclonal antibodies were produced against salivary gland sporozoites of three of the isolates. interaction of these monoclonal antibodies with the sporozoites was isolate specific, the exception being the anti-nih monoclonals which also reacted with mulligan strain sporozoites. inhibition of binding between the dif ... | 1985 | 3982450 |
| sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents. | two isomeric sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2) were prepared and tested for antimalarial activity. the compounds were evaluated for blood schizonticidal activity against plasmodium berghei in mice and radical curative activity against plasmodium cynomolgi in rhesus monkeys. in addition, they were evaluated for causal prophylactic activity against plasmodium berghei yoelii in mice. both compounds were more active and less toxi ... | 1985 | 4068013 |
| [therapeutic effect of pyronaridine given intragastrically on plasmodium cynomolgi-infected rhesus monkeys]. | 1985 | 4072704 | |
| activities of the tetrahydrofuran derivative, ba-41,799, against plasmodium cynomolgi infections in rhesus monkeys. | ba-41,799, a tetrahydrofuran derivative that at one time attracted considerable interest as an antimalarial agent because of a combination of structural novelty with activities against infections with plasmodium berghei and plasmodium berghei yoelii in mice, has been evaluated for its capacities to effect prophylaxis and radical cure in rhesus monkeys challenged or already infected with sporozoites of the drug-susceptible ro strain or the pyrimethamine-resistant ro/pm strain of plasmodium cynomo ... | 1985 | 3985599 |
| infection of aotus azarae boliviensis monkeys with the ro strain of plasmodium cynomolgi. | 1985 | 4093822 | |
| 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents. | five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against plasmodium cynomolgi in rhesus monkeys and for blood schizonticidal antimalarial activity against plasmodium berghei in mice. in addition, they were evaluated for causal prophylactic antimalarial activity against plasmodium berghei yoelii in mice. one compound, 4-ethyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2b), showed radical curative activity equivalent to ... | 1985 | 4067985 |
| [antimalarial activities of hydroxypiperaquine and its phosphate against plasmodium berghei and plasmodium cynomolgi]. | 1984 | 6232823 | |
| interactions between oral contraceptives and malaria infections in rhesus monkeys. | the interaction of oral contraceptives with malaria infection (plasmodium cynomolgi b and p. coatneyi) in adult female rhesus monkeys (macaca mulatta) was studied. the oral contraceptives (norinyl and ovral-28) were administered for 12 consecutive menstrual cycles, from day 5 to 25 of each cycle, at either (1/3) of the human dose of norinyl (norethisterone 0.33 mg + ethinylestradiol 0.012 mg) or (1/6) of the human dose of ovral-28 (norgestrel 0.083 mg + ethinylestradiol 0.008 mg).the animals wer ... | 1984 | 6335851 |
| [continuous cultivation of erythrocytic plasmodium cynomolgi in vitro]. | 1984 | 6509747 | |
| an evaluation of plasmodium cynomolgi bastianellii and plasmodium knowlesi antigens in the seroepidemiology of human malaria using indirect haemagglutination test. | 1984 | 6536544 | |
| activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with plasmodium cynomolgi in rhesus monkeys. | the studies summarized in this report were concerned with the capacities of repository preparations of cycloguanil pamoate (cgt-p) to protect rhesus monkeys against infections with drug-susceptible and pyrimethamine-resistant strains of plasmodium cynomolgi. administered intramuscularly as a suspension in an oleaginous vehicle, cgt-p (i) provided long-term protection against single and repetitive challenges of rhesus monkeys with sporozoites of the drug-susceptible b and ro strains, (ii) effecte ... | 1984 | 6393864 |
| evaluation of plasmodium cynomolgi b antigen in enzyme linked immunosorbent assay (elisa) test for human malaria. | 1984 | 6399263 | |
| continuous in vitro cultivation of erythrocytic plasmodium cynomolgi. | 1984 | 6432472 | |
| sporozoite-induced plasmodium cynomolgi infections in captive born macaca fascicularis. | capability of captive born cynomolgus monkeys to substitute for rhesus in the plasmodium cynomolgi radical curative antimalarial drug development model was examined. eighteen monkeys divided into 3 groups were given standard or high doses of sporozoites intravenously. one group of 4 received 0.8 - 1.6 x 10(6) and a second group of 8 received 0.3 - 1.0 x 10(7) sporozoites. the third group of 6 was splenectomized and then received 3.0 - 4.0 x 10(6). the 2 groups of intact monkeys developed a persi ... | 1984 | 6740373 |
| [studies on the biological characteristics and the strain-type of plasmodium cynomolgi maintained in china]. | 1984 | 6518634 | |
| circumsporozoite gene of plasmodium cynomolgi (gombak):cdna cloning and expression of the repetitive circumsporozoite epitope. | we report the identification, sequence, and expression in escherichia coli of the immunodominant epitope of the circumsporozoite (cs) gene of plasmodium cynomolgi (gombak), a simian malaria parasite. this epitope is encoded by a dna sequence that is tandemly repeated 10 times in the cdna clone. subclones that contain and express only repeats and in variable number have been constructed. we show that the binding of a specific anti-cs protein monoclonal antibody correlates positively with the numb ... | 1984 | 6209717 |
| [a combined regimen of pyronaridin-artemether-chloroquine (pac) for the treatment of plasmodium cynomolgi infection in the rhesus monkey]. | 1984 | 6536163 | |
| evolutionary relatedness of plasmodium species as determined by the structure of dna. | malaria parasites can be grouped evolutionarily by analysis of dna composition and genome arrangement. those that vary widely with regard to host range, morphology, and biological characteristics fit into only a small number of distinctive groups. the dna of the human parasite plasmodium falciparum fits into a group that includes rodent and avian malarias and is unlike the dna of other primate malaria parasites. the dna of plasmodium vivax, which is also a human parasite, fits into a distinctly ... | 1984 | 6382604 |
| appraisals of compounds of diverse chemical classes for capacities to cure infections with sporozoites of plasmodium cynomolgi. | compounds (265) of widely diverse structures were appraised for radical curative activity in rhesus monkeys infected with sporozoites of the b strain of plasmodium cynomolgi, using an evaluation system that provided a preliminary assessment with from 0.1-1.0 g of compound and tests against one to five active infections. none of 32 compounds in a miscellaneous structure category, none of seven agents of antibiotic origin, none of 12 1,5-naphthyridines, and none of seven 7-aminoquinolines exhibite ... | 1983 | 6837838 |
| [biological characteristics of simian malaria model of plasmodium cynomolgi-anopheles stephensi system and its response to antimalarials]. | 1983 | 6679168 | |
| relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with plasmodium cynomolgi in rhesus monkeys. | evaluation of 200 8-aminoquinolines for the capacities to effect radical cure of infections with sporozoites of plasmodium cynomolgi in rhesus monkeys led to identification of 34 derivatives with activity equal or superior to that of primaquine and to characterization of substituents on the quinoline nucleus and side chain that favored or prejudiced curative activity. of the 34 derivatives, 19 were as active as primaquine, 9 were twice as active, and 6 were four times as active. with respect to ... | 1983 | 6660845 |
| timing of stages and changes in numbers of multiply-infected erythrocytes during the asexual cycle of plasmodium cynomolgi bastianellii. | previous evaluations of the timing of developing stages in the erythrocytic cycle of the simian malaria parasite, plasmodium cynomolgi, a frequently used model for relapsing malaria in man, have depended on procurement of blood samples at 4- or 6-hourly intervals. this brief report describes the blood cycle as determined from hourly bleedings, thus providing a more discriminating sequence usable for immunochemical or biochemical study of specific stages. the approximate timing of development for ... | 1983 | 6859395 |
| malaria parasites--discovery of the early liver form. | infections of mammalian malaria parasites start when sporozoites from an infected anopheline mosquito are injected into the bloodstream of the host. the sporozoites enter the hepatocytes and become transformed into exoerythrocytic schizonts. since the discovery of the primate parasite plasmodium cynomolgi in monkey hepatocytes and the rodent parasite plasmodium berghei in hamster hepatocytes, the ultrastructure of these stages has been extensively studied both in primate and rodent plasmodia. th ... | 1983 | 6339945 |
| [establishment of monkey model of plasmodium cynomolgi-anopheles stephensi system and its use for tissue shizontocide test]. | 1982 | 6216007 | |
| presbytis entellus and macaca radiata as new hosts for experimental plasmodium cynomolgi bastianellii infection. | 1982 | 7174004 | |
| antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. a highly effective series of blood and tissue schizonticidal agents. | a series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity. the compounds were tested for suppressive activity against plasmodium berghei in mice and for radical curative activity against plasmodium cynomolgi in the rhesus monkey. the compounds were not only significantly superior to primaquine as radical curative agents but also were suprisingly highly effective as suppressive agents. | 1982 | 7131488 |
| observations on early and late post-sporozoite tissue stages in primate malaria. ii. the hypnozoite of plasmodium cynomolgi bastianellii from 3 to 105 days after infection, and detection of 36- to 40-hour pre-erythrocytic forms. | confirmation of the existence of a persistent, uninucleate, dormant pre-erythrocytic stage, the hypnozoite, of the relapsing simian malaria parasite, plasmodium cynomolgi bastianellii, has been obtained by means of experiments involving the intravenous injection into susceptible monkeys of 48 to 85 x 10(6) sporozoites derived from mosquitoes of a different species and source than employed previously. the development of these hypnozoites was traced from 3 days until 105 days after sporozoite inoc ... | 1982 | 7041663 |
| response to plasmodium cynomolgi infection in a protein deficient host. | 1982 | 7152561 | |
| antimalarials. 13. 5-alkoxy analogues of 4-methylprimaquine. | a series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in mice and for radical curative antimalarial activity against plasmodium cynomolgi in the rhesus monkey. although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly ef ... | 1982 | 6750123 |
| observations on early and late post-sporozoite tissue stages in primate malaria. i. discovery of a new latent form of plasmodium cynomolgi (the hypnozoite), and failure to detect hepatic forms within the first 24 hours after infection. | previous work in this laboratory has demonstrated the ability of the immunofluorescence technique to detect pre-erythrocytic stages of the primate malaria parasite, plasmodium cynomolgi bastianellii, in hepatic tissue obtained as early as 48 hours after sporozoite inoculation. in an attempt to visualize still earlier post-sporozoite stages, hepatic tissue obtained from a rhesus monkey infected with 12,000,000 sporozoites was examined at 2, 12, 24, and 48 hours after inoculation, employing antise ... | 1982 | 7058977 |
| plasmodium cynomolgi infections in the rhesus monkey. | 1982 | 7081552 | |
| [effects of nitroquine on sporogenic cycle of plasmodium cynomolgi]. | 1982 | 6219546 | |
| synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines. | three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. it also possessed outstanding causal prophylactic activity against plasmodium cynomolgi in rhesus monkeys at very low dosages. | 1981 | 7205891 |
| comparative efficacies of quinine and chloroquine as companions to primaquine in a curative drug regimen. | a comparison has been made of the capacities of chloroquine and quinine to serve as companions to primaquine in curing established infections with sporozoites of the m or b strains of plasmodium cynomolgi in rhesus monkeys. the results indicated that chloroquine was slightly but consistently more effective than quinine in this role. this finding provides support for use of chloroquine as the companion blood schizonticide in the current experimental animal-based search for improved tissue schizon ... | 1981 | 7212167 |
| the 48-hour exoerythrocytic stage of plasmodium cynomolgi bastianellii. | detection and specific identification of the 48-hour exoerythrocytic stage of the primate malaria parasite, plasmodium cynomolgi bastianellii, was accomplished by means of a highly specific indirect immunofluorescence technique (ifa) applied to hepatic tissue fixed in carnoy's solution. the 48-hour forms appeared as round-to-slightly-oval bodies of average mean diameter 3.0 micrometers (9 parasites) and lying with the cytoplasm of individual hepatic parenchymal cells; each possessed one to three ... | 1981 | 7011070 |
| cultivation in vitro of the vivax-type malaria parasite plasmodium cynomolgi. | the vivax-type simian malaria parasite plasmodium cynomologi was cultured in vitro by both the candle jar method and the continuous flow technique, with rhesus monkey erythrocytes and rpmi 1640 medium supplemented with hepes buffer and human serum. after 6 weeks in culture, the growth of the parasite had permitted a 5 x 10(6) cumulative dilution of the original inoculum. cultured parasites remained infective to rhesus monkeys and exhibited a reversible decrease in the ameboid behavior of their t ... | 1981 | 7233207 |
| [two accidental human infections by plasmodium cynomolgi bastianellii. a clinical and serological study]. | 1980 | 7016051 | |
| plasmodium cynomolgi: folic acid antagonist combinations for treatment of malaria in rhesus monkeys. | 1980 | 6767622 | |
| synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics. | a series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against plasmodium berghei in mice and leishmania donovani in hamsters. 8-[[6-(diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against l. donovani. 2-ethyl-4-methylprimaquine (7a) was evaluated against plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine. | 1980 | 6770089 |
| enhancement of a simian malarial infection (plasmodium cynomolgi) in mosquitoes fed on rhesus (macaca mulatta) previously infected with an unrelated malaria (plasmodium knowlesi). | 1979 | 111568 | |
| freeze-fracture study of malaria sporozoites: antibody-induced changes of the pellicular membrane. | plasmodium cynomolgi, plasmodium knowlesi, and plasmodium berghei sporozoites, before and after incubation with immune serum, were studied after freeze-fracture by electron microscopy. there were evenly distributed numerous intramembranous particles (imp) on the p face of the outer membrane. the e face of the plasma membrane had fewer imp than its p face. the e face of the intermediate membrane had few imp and also linear arrays of slightly raised ridges running the length of the parasite. the p ... | 1979 | 385856 |
| studies on the 2,4-diamino-6 substituted quinazolines. i. antimalarial activities of 2,4-diamino-6-[(3,4-dichlorobenzyl)-nitrosoamino]-quinazoline (ci-679) as exhibited in rhesus monkeys infected with the ro or ro/pm strains of plasmodium cynomolgi. | this report summarizes the results of appraisals of various activities of ci-679 (a 2,4-diamino-6-amino-substituted quinazoline) in rhesus monkeys infected with the ro and ro/pm strains of plasmodium cynomolgi. in subjects inoculated with sporozoites, ci-679, administered in appropriate schedules in doses up to and including the maximum tolerated level, neither prevented development of infections with these strains nor cured those already established. although these evaluations showed that ci-67 ... | 1979 | 114064 |
| primaquine analogues: derivatives of 4-amino-2-methoxyacridine. | based on the antimalarial activity of primaquine (1a) and its 4-methyl analogue 1b, 4-aminoacridinyl analogues, 4-[(4-amino-1-methylbutyl)amino]-2-methoxyacridine (2a) and 4-[(4-amino-1-methylbutyl)amino]-2-methoxy-9-methylacridine (2b), were prepared and evaluated as potential tissue schizonticidal agents. these compounds were found to be substantially less active than primaquine against plasmodium cynomolgi in the rhesus monkey. the antileishmanial activity in hamsters of 4-[[6-(diethylamino)h ... | 1979 | 117105 |
| resolution of antimalarial agents via complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid. | the resolution of several antimalarial agents via pi-complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid (tapa) is reported. since this represents the first use of this agent for the resolution of amines, some details of the separations are presented. the method proved successful for resolving weakly alkaline amines that did not form stable salts with common resolving acids, highly insoluble amines that did not form soluble salts with usual resolving acids, ... | 1978 | 349156 |
| synthesis of 2-substituted primaquine analogues as potential antimalarials. | a series of 2-substituted primaquine analogues has been synthesized and evaluated against plasmodium berghei in the mouse and leishmania donovani in the hamster. three members (3a,d,e) of the series were evaluated against plasmodium cynomolgi in the rhesus monkey. one analogue (3d) was evaluated against trypanosoma rhodesiense in the mouse, and two (3b,e) were evaluated against schistosoma mansoni in the mouse. several analogues possessed significant activity against p. berghei (3e,f) and l. don ... | 1978 | 102798 |
| sporozoites of rodent and simian malaria, purified by anion exchangers, retain their immunogenicity and infectivity. | sporozoites of rodent malaria, plasmodium berghei, and simian malaria, plasmodium knowlesi and plasmodium cynomolgi, were partially separated from mosquito debris and microbial contaminants by passage of anopheles material through a deae-cellulose column. in addition to eliminating most of the contaminants (80-90%), this simple technic has made it possible to recover rapidly large numbers of viable sporozoites (55-75% yield), which have retained their infectivity, immunogenicity, and capacity to ... | 1978 | 351177 |
| plasmodium cynomolgi: effects of malaria infection on laboratory flight performance of anopheles stephensi mosquitoes. | 1977 | 403087 | |
| the characteristics of plasmodium cynomolgi infections in various old world primates. | 1977 | 405875 | |
| quantitative aspects of pyrimethamine-sulfonamide synergism. | the experiments described in this report have dealt with the dimensions of therapeutic potentiation achieved when combinations of pyrimethamine and sulfadiazine were administered to rhesus monkeys infected with a drug-susceptible strain of plasmodium cynomolgi or its pyrimethamine-resistant variant and to owl monkeys infected with strains of p. falciparum and p. vivax of varying degrees of resistance to this pyrimidine. these evaluations showed: 1) that when delivered in combination, the activit ... | 1977 | 410317 |
| antimalarials. 10. synthesis of 4-substituted primaquine analogues as candidate antimalarials. | primaquine (i) has been extensively used in combination with other drugs in the radical cure of relapsing malaria as well as for prophylaxis or the interruption of transmission. this, coupled with the activity data reported for 4-methylprimaquine (ii), has led to the synthesis of a series of 14 4-substituted analogues of i. in addition, three side-chain analogues of ii were prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in the rane mouse scre ... | 1977 | 411930 |
| synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials. | a series of 2-benzyloxy and 2-benzylthio analogues of primaquine has been synthesized and evaluated against plasmodium berghei in the mouse and plasmodium cynomolgi in the rhesus monkey. 8-aminoquinoline toxicity, as measured in the rane mouse screen, was reduced, and these compounds showed significant blood schizonticidal antimalarial activity in mice. in monkeys, significant tissue-schizonticidal activity was observed. | 1977 | 409843 |
| radical cure of infections with plasmodium cynomolgi: a function of total 8-aminoquinoline dose. | 1977 | 413444 | |
| comparison of the curative antimalarial activities and toxicities of primaquine and its d and l isomers. | this investigation was undertaken to determine whether either d-primaquine or l-primaquine has sufficient advantage over primaquine to warrant evaluation for curative activity in human volunteers infected with plasmodium vivax. it was found: (i) that the capacities of the isomers and the racemate to cure infections with plasmodium cynomolgi in rhesus monkeys were essentially identical; (ii) that the subacute toxicities of the isomers and racemate for this monkey were qualitatively the same, but ... | 1977 | 407841 |
| evaluating new antimalarial drugs against trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys. | an antimalarial drug testing system is described which utilizes trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys. the schizonticidal activity of standard antimalarial drugs in this system is reported. the system accurately predicted antimalarial activity in man of 8 of 9 compounds selected for clinical trials. | 1976 | 816211 |
| reduced 8-aminoquinoline analogues as potential antimalarial agents. | the synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-n,n-diethylaminoethyl)-8-(2-n,n-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline, and 2-substit ... | 1976 | 824447 |
| 5-aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials. | 5-(p-anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the plasmodium berghei and monkey prophylactic (plasmodium cynomolgi) tests. a new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. none of these compounds showed significant antimalarial or prophylactic activity. | 1976 | 824437 |
| transmission of plasmodium cynomolgi to aotus trivirgatus monkeys. | 1975 | 804032 | |
| incorporation of nucleic acid precursors by plasmodium cynomolgi in anopheles balabacensis. | autoradiography was used to study the incorporation of tritium-labelled nucleic acid precursors into the sporogonic stages of plasmodium cynomolgi in anopheles b. balabacensis. infected mosquitoes were fed on either 3h-adenine (5, 25 and 50 muci/ml or 3h-thymidine (50 muci/ml) for various periods after the blood meal. 3h-adenine was incorporated into dna and rna of the developing oocysts and the resulting sporozoites. midgut epithelial cells incorporated label from 3h-adenine into nuclear and cy ... | 1975 | 1189024 |
| plasmodium cynomolgi: influence of x-irradiation and sporozoite dilution on relapse patterns in infected rhesus monkeys. | 1974 | 4206933 | |
| studies on the antimalarial effects of rc-12 and wr 14,997 on the development of plasmodium cynomolgi in mosquitoes and rhesus monkeys. | 1974 | 4207342 | |
| gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. ii. action of the folic reductase inhibitors, chlorguanide, and pyrimethamine against plasmodium cynomolgi. | 1974 | 4413531 | |
| plasmodium cynomolgi malaria: accidental human infection. | 1973 | 4631763 | |
| plasmodium cynomolgi: the comparative infectiousness of individual rhesus monkeys. | 1973 | 4632461 | |
| gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. i. effect of single and multiple doses of primaquine on plasmodium cynomolgi. | 1973 | 4200769 | |
| accidental human infection with plasmodium cynomolgi bastianellii. | 1973 | 4207080 | |
| detection of early exoerythrocytic schizonts of plasmodium cynomolgi by immunofluorescence. | 1973 | 4123941 | |
| letter: the antimalarial activity of rc-12 against gametocytes and sporogony of plasmodium cynomolgi. | 1973 | 4204929 | |
| destruction of erythrocytes in monkeys (macaca mulatta) infected with plasmodium cynomolgi. | 1972 | 4621818 | |
| immunization of monkeys against plasmodium cynomolgi by x-irradiated sporozoites. | 1972 | 4624244 | |
| studies on the transmission of simian malaria. v. infection and transmission of the b strain of plasmodium cynomolgi. | 1972 | 4626891 | |
| studies on the prophylactic and radical curative activity of rc-12 against plasmodium cynomolgi in macaca mulatta. | the compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (rc-12) has been shown to be active against the exoerythrocytic (ee) stages of the malaria parasite. experiments on plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of ee stages. the usefulness of rc-12 for effecting radical cures is, however, still open to doubt. | 1972 | 4631044 |
| the action of 'terramycin' on the primary exoerythrocytic development of plasmodium vivax and plasmodium cynomolgi ceylonensis. | 1971 | 4993964 | |
| [the evolution of fluorescent antibodies in monkeys in the course of an experimental infection with plasmodium cynomolgi bastianellii]. | 1971 | 5005960 | |
| transformation of the plasmodium cynomolgi oocyst. | 1971 | 5547075 | |
| fine structure of the exoerythrocytic stage of plasmodium cynomolgi. | the light microscopy of primate exoerythrocytic stages (liver stage) of malaria is well described. this report demonstrates the ultrastructure of the 7-day exoerythrocytic stage of plasmodium cynomolgi in the liver of a rhesus monkey. | 1970 | 4990053 |
| [studies on immunity and serological reactions in monkeys after infection with plasmodium cynomolgi bastianelli]. | 1970 | 4990718 | |
| morphological characteristics of the sporogonous cycle of plasmodium cynomolgi in anopheles stephensi. | 1970 | 4904946 | |
| the activities of chlorinated lincomycin derivatives against infections with plasmodium cynomolgi in macaca mulatta. | 1970 | 4984584 |