Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| evolutionary profile of the circumsporozoite gene of the plasmodium cynomolgi complex. | the circumsporozoite genes and flanking sequences of the ceylon, gombak, london, nih and mulligan strains of the plasmodium cynomolgi complex were isolated by molecular cloning and compared. about 11,000 bases of the gombak clone were mapped in detail and found to have their exact counterparts in all the other strains. in contrast the epitope-encoding region, a 600-base sequence consisting of short tandem repeats, exhibited no homology with any of the other clones. these findings show that diffe ... | 1986 | 3735434 |
| 4,5-disubstituted primaquine analogues as potential antimalarial agents. | three 4,5-disubstituted primaquine analogues were synthesized and evaluated for radical curative activity against plasmodium cynomolgi in rhesus monkeys. one of the compounds showed moderate activity; however, none of the three compounds were as active as the lead compounds 5-methoxy-4-methylprimaquine and 4-(methoxy-methyl)-5-[m-(trifluoromethyl)phenoxy]primaquine. | 1986 | 3746825 |
| [further studies on the relapse of plasmodium cynomolgi in rhesus monkeys]. | 1986 | 3769157 | |
| [on the residual activity of pyronaridine against plasmodium cynomolgi in rhesus monkeys]. | 1986 | 3769158 | |
| the circumsporozoite gene of the plasmodium cynomolgi complex. | an analysis of the circumsporozoite (cs) genes of six closely related plasmodia is presented. like other plasmodial antigens, the cs protein contains tandem repeats flanked by conventional nonrepeated sequences. our analysis shows that the repeats, which encode the immunodominant epitope of the cs protein, diverge more rapidly than the remainder of the gene, and that the maintenance and evolution of the repeats cannot be explained as the result of selection at the protein level. we argue that a ... | 1987 | 3802196 |
| enhancement of the curative activity of primaquine by concomitant administration of mirincamycin. | mirincamycin, a lincomycin derivative with unequivocal but limited activity against the pre-erythrocytic and persisting exoerythrocytic stages of plasmodium cynomolgi, has been evaluated for capacity to enhance the radical curative potential of the conventional primaquine-chloroquine combination. established infections with sporozoites of the above plasmodium in rhesus monkeys served this evaluation. the results showed that the dose of primaquine required for cure of 50% of active infections was ... | 1985 | 3885847 |
| antigenic diversity of the circumsporozoite proteins in the plasmodium cynomolgi complex. | antigenic diversity was observed in the circumsporozoite (cs) proteins of five of the six plasmodium cynomolgi isolates (nih, mulligan, london, gombak, ceylon, ro) that we examined. monoclonal antibodies were produced against salivary gland sporozoites of three of the isolates. interaction of these monoclonal antibodies with the sporozoites was isolate specific, the exception being the anti-nih monoclonals which also reacted with mulligan strain sporozoites. inhibition of binding between the dif ... | 1985 | 3982450 |
| activities of the tetrahydrofuran derivative, ba-41,799, against plasmodium cynomolgi infections in rhesus monkeys. | ba-41,799, a tetrahydrofuran derivative that at one time attracted considerable interest as an antimalarial agent because of a combination of structural novelty with activities against infections with plasmodium berghei and plasmodium berghei yoelii in mice, has been evaluated for its capacities to effect prophylaxis and radical cure in rhesus monkeys challenged or already infected with sporozoites of the drug-susceptible ro strain or the pyrimethamine-resistant ro/pm strain of plasmodium cynomo ... | 1985 | 3985599 |
| observations on early and late post-sporozoite tissue stages in primate malaria. iii. further attempts to find early forms and to correlate hypnozoites with growing exo-erythrocytic schizonts and parasitaemic relapses in plasmodium cynomolgi bastianellii infections. | rhesus monkeys were heavily infected with sporozoites of plasmodium cynomolgi bastianellii in an attempt to demonstrate the site of invasion of sporozoites into tissue cells and their growth there. further attempts were made to correlate the appearance and loss of hypnozoites with parasitaemic relapses. hypnozoites were demonstrated and once again shown to decrease in numbers over 229 days during which time the infection showed parasitaemic relapses. liver biopsies taken at two-day intervals for ... | 1985 | 4002302 |
| 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents. | five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against plasmodium cynomolgi in rhesus monkeys and for blood schizonticidal antimalarial activity against plasmodium berghei in mice. in addition, they were evaluated for causal prophylactic antimalarial activity against plasmodium berghei yoelii in mice. one compound, 4-ethyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2b), showed radical curative activity equivalent to ... | 1985 | 4067985 |
| sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents. | two isomeric sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2) were prepared and tested for antimalarial activity. the compounds were evaluated for blood schizonticidal activity against plasmodium berghei in mice and radical curative activity against plasmodium cynomolgi in rhesus monkeys. in addition, they were evaluated for causal prophylactic activity against plasmodium berghei yoelii in mice. both compounds were more active and less toxi ... | 1985 | 4068013 |
| [therapeutic effect of pyronaridine given intragastrically on plasmodium cynomolgi-infected rhesus monkeys]. | 1985 | 4072704 | |
| antimalarial activities and subacute toxicity of rc-12, a 4-amino-substituted pyrocatechol. | rc-12 [1,2-dimethoxy-4-(bis-diethylaminoethyl)-amino-5-bromobenzene] was evaluated for prophylactic, radical curative, and suppressive activities against infections with plasmodium cynomolgi and subacute toxicity in rhesus monkeys. applied as a prophylactic agent, rc-12, administered in doses of 6.25 to 25.0 mg/kg daily throughout the incubation period, provided near-complete to complete protection against 10(5) to 10(6) times the minimum infective dose of sporozoites. applied as a suppressive a ... | 1985 | 4091527 |
| infection of aotus azarae boliviensis monkeys with the ro strain of plasmodium cynomolgi. | 1985 | 4093822 | |
| detection of early exoerythrocytic schizonts of plasmodium cynomolgi by immunofluorescence. | 1973 | 4123941 | |
| immune response of man to inoculation with plasmodium cynomolgi and challenge with p. vivax. | 1966 | 4161488 | |
| gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. i. effect of single and multiple doses of primaquine on plasmodium cynomolgi. | 1973 | 4200769 | |
| letter: the antimalarial activity of rc-12 against gametocytes and sporogony of plasmodium cynomolgi. | 1973 | 4204929 | |
| plasmodium cynomolgi: influence of x-irradiation and sporozoite dilution on relapse patterns in infected rhesus monkeys. | 1974 | 4206933 | |
| accidental human infection with plasmodium cynomolgi bastianellii. | 1973 | 4207080 | |
| studies on the antimalarial effects of rc-12 and wr 14,997 on the development of plasmodium cynomolgi in mosquitoes and rhesus monkeys. | 1974 | 4207342 | |
| biology of the simian malarias of southeast asia. 3. sporogony of the cambodian strain of plasmodium cynomolgi. | 1966 | 4381840 | |
| biology of the simian malarias of southeast asia. iv. sporogony of four strains of plasmodium cynomolgi. | 1966 | 4381841 | |
| [susceptibility of various anopheles species to the pathogenic agent of simian malaria, plasmodium cynomolgi bastinelli]. | 1968 | 4386476 | |
| gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. ii. action of the folic reductase inhibitors, chlorguanide, and pyrimethamine against plasmodium cynomolgi. | 1974 | 4413531 | |
| destruction of erythrocytes in monkeys (macaca mulatta) infected with plasmodium cynomolgi. | 1972 | 4621818 | |
| immunization of monkeys against plasmodium cynomolgi by x-irradiated sporozoites. | 1972 | 4624244 | |
| studies on the transmission of simian malaria. v. infection and transmission of the b strain of plasmodium cynomolgi. | 1972 | 4626891 | |
| studies on the prophylactic and radical curative activity of rc-12 against plasmodium cynomolgi in macaca mulatta. | the compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (rc-12) has been shown to be active against the exoerythrocytic (ee) stages of the malaria parasite. experiments on plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of ee stages. the usefulness of rc-12 for effecting radical cures is, however, still open to doubt. | 1972 | 4631044 |
| plasmodium cynomolgi malaria: accidental human infection. | 1973 | 4631763 | |
| plasmodium cynomolgi: the comparative infectiousness of individual rhesus monkeys. | 1973 | 4632461 | |
| [cross serological reactions between plasmodium falciparum and plasmodium cynomolgi bastianellii. application to the serodiagnosis, by immunofluorescence, of human plasmodium falciparum malaria]. | 1966 | 4860834 | |
| morphological characteristics of the sporogonous cycle of plasmodium cynomolgi in anopheles stephensi. | 1970 | 4904946 | |
| fluorescent-antibody studies on simian malaria. ii. development of antibodies to plasmodium cynomolgi. | 1967 | 4960704 | |
| antimalarial activity of tetrahydrohomopteroic acid. | tetrahydrohomopteroic acid, an analog of tetrahydrofolic acid, shows antimalarial activity against plasmodium cynomolgi and a pyrimethamine-resistant variant of this organism. | 1967 | 4960875 |
| activities of trimethoprim against infections with pyrimethamine susceptible and resistant strains of plasmodium cynomolgi. | 1969 | 4976952 | |
| immunological studies with simian malarias. i. antigenic variants of plasmodium cynomolgi bastianellii. | 1969 | 4978046 | |
| increased virulence of plasmodium cynomolgi bastianellii in the rhesus monkey. | 1969 | 4978542 | |
| activity of chlorinated lincomycin analogues against plasmodium cynomolgi in rhesus monkeys. | 1969 | 4978594 | |
| the activities of chlorinated lincomycin derivatives against infections with plasmodium cynomolgi in macaca mulatta. | 1970 | 4984584 | |
| fine structure of the exoerythrocytic stage of plasmodium cynomolgi. | the light microscopy of primate exoerythrocytic stages (liver stage) of malaria is well described. this report demonstrates the ultrastructure of the 7-day exoerythrocytic stage of plasmodium cynomolgi in the liver of a rhesus monkey. | 1970 | 4990053 |
| [studies on immunity and serological reactions in monkeys after infection with plasmodium cynomolgi bastianelli]. | 1970 | 4990718 | |
| the action of 'terramycin' on the primary exoerythrocytic development of plasmodium vivax and plasmodium cynomolgi ceylonensis. | 1971 | 4993964 | |
| [the evolution of fluorescent antibodies in monkeys in the course of an experimental infection with plasmodium cynomolgi bastianellii]. | 1971 | 5005960 | |
| [the use of plasmodium cynomolgi bastianellii in serodiagnosis, by means of immune-fluorescence, of human malaria]. | 1965 | 5334893 | |
| plasmodium cynomolgi: sources of variation in susceptibility of anopheles quadrimaculatus, a. balabacensis, and a. stephensi. | 1970 | 5413008 | |
| a note on the effects of antimalarial drugs on the sporogonous cycle of plasmodium cynomolgi in anopheles stephensi. | 1970 | 5483911 | |
| plasmodium cynomolgi: x-irradiation and development of exo-erythrocytic schizonts in macaca mulatta. | 1970 | 5499672 | |
| transformation of the plasmodium cynomolgi oocyst. | 1971 | 5547075 | |
| [comparative studies of the development of plasmodium cynomolgi bastianellii in anopheles stephensi and a. albimanus]. | 1968 | 5715367 | |
| biology of the simian malarias of southeast asia. ii. the susceptibility of some malaysian mosquitoes to infection with five strains of plasmodium cynomolgi. | 1966 | 5969101 | |
| circumsporozoite gene of plasmodium cynomolgi (gombak):cdna cloning and expression of the repetitive circumsporozoite epitope. | we report the identification, sequence, and expression in escherichia coli of the immunodominant epitope of the circumsporozoite (cs) gene of plasmodium cynomolgi (gombak), a simian malaria parasite. this epitope is encoded by a dna sequence that is tandemly repeated 10 times in the cdna clone. subclones that contain and express only repeats and in variable number have been constructed. we show that the binding of a specific anti-cs protein monoclonal antibody correlates positively with the numb ... | 1984 | 6209717 |
| [establishment of monkey model of plasmodium cynomolgi-anopheles stephensi system and its use for tissue shizontocide test]. | 1982 | 6216007 | |
| [effects of nitroquine on sporogenic cycle of plasmodium cynomolgi]. | 1982 | 6219546 | |
| [antimalarial activities of hydroxypiperaquine and its phosphate against plasmodium berghei and plasmodium cynomolgi]. | 1984 | 6232823 | |
| interactions between oral contraceptives and malaria infections in rhesus monkeys. | the interaction of oral contraceptives with malaria infection (plasmodium cynomolgi b and p. coatneyi) in adult female rhesus monkeys (macaca mulatta) was studied. the oral contraceptives (norinyl and ovral-28) were administered for 12 consecutive menstrual cycles, from day 5 to 25 of each cycle, at either (1/3) of the human dose of norinyl (norethisterone 0.33 mg + ethinylestradiol 0.012 mg) or (1/6) of the human dose of ovral-28 (norgestrel 0.083 mg + ethinylestradiol 0.008 mg).the animals wer ... | 1984 | 6335851 |
| malaria parasites--discovery of the early liver form. | infections of mammalian malaria parasites start when sporozoites from an infected anopheline mosquito are injected into the bloodstream of the host. the sporozoites enter the hepatocytes and become transformed into exoerythrocytic schizonts. since the discovery of the primate parasite plasmodium cynomolgi in monkey hepatocytes and the rodent parasite plasmodium berghei in hamster hepatocytes, the ultrastructure of these stages has been extensively studied both in primate and rodent plasmodia. th ... | 1983 | 6339945 |
| evolutionary relatedness of plasmodium species as determined by the structure of dna. | malaria parasites can be grouped evolutionarily by analysis of dna composition and genome arrangement. those that vary widely with regard to host range, morphology, and biological characteristics fit into only a small number of distinctive groups. the dna of the human parasite plasmodium falciparum fits into a group that includes rodent and avian malarias and is unlike the dna of other primate malaria parasites. the dna of plasmodium vivax, which is also a human parasite, fits into a distinctly ... | 1984 | 6382604 |
| activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with plasmodium cynomolgi in rhesus monkeys. | the studies summarized in this report were concerned with the capacities of repository preparations of cycloguanil pamoate (cgt-p) to protect rhesus monkeys against infections with drug-susceptible and pyrimethamine-resistant strains of plasmodium cynomolgi. administered intramuscularly as a suspension in an oleaginous vehicle, cgt-p (i) provided long-term protection against single and repetitive challenges of rhesus monkeys with sporozoites of the drug-susceptible b and ro strains, (ii) effecte ... | 1984 | 6393864 |
| evaluation of plasmodium cynomolgi b antigen in enzyme linked immunosorbent assay (elisa) test for human malaria. | 1984 | 6399263 | |
| continuous in vitro cultivation of erythrocytic plasmodium cynomolgi. | 1984 | 6432472 | |
| [continuous cultivation of erythrocytic plasmodium cynomolgi in vitro]. | 1984 | 6509747 | |
| [studies on the biological characteristics and the strain-type of plasmodium cynomolgi maintained in china]. | 1984 | 6518634 | |
| [a combined regimen of pyronaridin-artemether-chloroquine (pac) for the treatment of plasmodium cynomolgi infection in the rhesus monkey]. | 1984 | 6536163 | |
| an evaluation of plasmodium cynomolgi bastianellii and plasmodium knowlesi antigens in the seroepidemiology of human malaria using indirect haemagglutination test. | 1984 | 6536544 | |
| relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with plasmodium cynomolgi in rhesus monkeys. | evaluation of 200 8-aminoquinolines for the capacities to effect radical cure of infections with sporozoites of plasmodium cynomolgi in rhesus monkeys led to identification of 34 derivatives with activity equal or superior to that of primaquine and to characterization of substituents on the quinoline nucleus and side chain that favored or prejudiced curative activity. of the 34 derivatives, 19 were as active as primaquine, 9 were twice as active, and 6 were four times as active. with respect to ... | 1983 | 6660845 |
| [biological characteristics of simian malaria model of plasmodium cynomolgi-anopheles stephensi system and its response to antimalarials]. | 1983 | 6679168 | |
| sporozoite-induced plasmodium cynomolgi infections in captive born macaca fascicularis. | capability of captive born cynomolgus monkeys to substitute for rhesus in the plasmodium cynomolgi radical curative antimalarial drug development model was examined. eighteen monkeys divided into 3 groups were given standard or high doses of sporozoites intravenously. one group of 4 received 0.8 - 1.6 x 10(6) and a second group of 8 received 0.3 - 1.0 x 10(7) sporozoites. the third group of 6 was splenectomized and then received 3.0 - 4.0 x 10(6). the 2 groups of intact monkeys developed a persi ... | 1984 | 6740373 |
| antimalarials. 13. 5-alkoxy analogues of 4-methylprimaquine. | a series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in mice and for radical curative antimalarial activity against plasmodium cynomolgi in the rhesus monkey. although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly ef ... | 1982 | 6750123 |
| plasmodium cynomolgi: folic acid antagonist combinations for treatment of malaria in rhesus monkeys. | 1980 | 6767622 | |
| synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogues as potential antiparasitics. | a series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against plasmodium berghei in mice and leishmania donovani in hamsters. 8-[[6-(diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against l. donovani. 2-ethyl-4-methylprimaquine (7a) was evaluated against plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine. | 1980 | 6770089 |
| appraisals of compounds of diverse chemical classes for capacities to cure infections with sporozoites of plasmodium cynomolgi. | compounds (265) of widely diverse structures were appraised for radical curative activity in rhesus monkeys infected with sporozoites of the b strain of plasmodium cynomolgi, using an evaluation system that provided a preliminary assessment with from 0.1-1.0 g of compound and tests against one to five active infections. none of 32 compounds in a miscellaneous structure category, none of seven agents of antibiotic origin, none of 12 1,5-naphthyridines, and none of seven 7-aminoquinolines exhibite ... | 1983 | 6837838 |
| timing of stages and changes in numbers of multiply-infected erythrocytes during the asexual cycle of plasmodium cynomolgi bastianellii. | previous evaluations of the timing of developing stages in the erythrocytic cycle of the simian malaria parasite, plasmodium cynomolgi, a frequently used model for relapsing malaria in man, have depended on procurement of blood samples at 4- or 6-hourly intervals. this brief report describes the blood cycle as determined from hourly bleedings, thus providing a more discriminating sequence usable for immunochemical or biochemical study of specific stages. the approximate timing of development for ... | 1983 | 6859395 |
| the 48-hour exoerythrocytic stage of plasmodium cynomolgi bastianellii. | detection and specific identification of the 48-hour exoerythrocytic stage of the primate malaria parasite, plasmodium cynomolgi bastianellii, was accomplished by means of a highly specific indirect immunofluorescence technique (ifa) applied to hepatic tissue fixed in carnoy's solution. the 48-hour forms appeared as round-to-slightly-oval bodies of average mean diameter 3.0 micrometers (9 parasites) and lying with the cytoplasm of individual hepatic parenchymal cells; each possessed one to three ... | 1981 | 7011070 |
| [two accidental human infections by plasmodium cynomolgi bastianellii. a clinical and serological study]. | 1980 | 7016051 | |
| observations on early and late post-sporozoite tissue stages in primate malaria. ii. the hypnozoite of plasmodium cynomolgi bastianellii from 3 to 105 days after infection, and detection of 36- to 40-hour pre-erythrocytic forms. | confirmation of the existence of a persistent, uninucleate, dormant pre-erythrocytic stage, the hypnozoite, of the relapsing simian malaria parasite, plasmodium cynomolgi bastianellii, has been obtained by means of experiments involving the intravenous injection into susceptible monkeys of 48 to 85 x 10(6) sporozoites derived from mosquitoes of a different species and source than employed previously. the development of these hypnozoites was traced from 3 days until 105 days after sporozoite inoc ... | 1982 | 7041663 |
| observations on early and late post-sporozoite tissue stages in primate malaria. i. discovery of a new latent form of plasmodium cynomolgi (the hypnozoite), and failure to detect hepatic forms within the first 24 hours after infection. | previous work in this laboratory has demonstrated the ability of the immunofluorescence technique to detect pre-erythrocytic stages of the primate malaria parasite, plasmodium cynomolgi bastianellii, in hepatic tissue obtained as early as 48 hours after sporozoite inoculation. in an attempt to visualize still earlier post-sporozoite stages, hepatic tissue obtained from a rhesus monkey infected with 12,000,000 sporozoites was examined at 2, 12, 24, and 48 hours after inoculation, employing antise ... | 1982 | 7058977 |
| plasmodium cynomolgi infections in the rhesus monkey. | 1982 | 7081552 | |
| antimalarials. 14. 5-(aryloxy)-4-methylprimaquine analogues. a highly effective series of blood and tissue schizonticidal agents. | a series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity. the compounds were tested for suppressive activity against plasmodium berghei in mice and for radical curative activity against plasmodium cynomolgi in the rhesus monkey. the compounds were not only significantly superior to primaquine as radical curative agents but also were suprisingly highly effective as suppressive agents. | 1982 | 7131488 |
| response to plasmodium cynomolgi infection in a protein deficient host. | 1982 | 7152561 | |
| presbytis entellus and macaca radiata as new hosts for experimental plasmodium cynomolgi bastianellii infection. | 1982 | 7174004 | |
| synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines. | three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. it also possessed outstanding causal prophylactic activity against plasmodium cynomolgi in rhesus monkeys at very low dosages. | 1981 | 7205891 |
| comparative efficacies of quinine and chloroquine as companions to primaquine in a curative drug regimen. | a comparison has been made of the capacities of chloroquine and quinine to serve as companions to primaquine in curing established infections with sporozoites of the m or b strains of plasmodium cynomolgi in rhesus monkeys. the results indicated that chloroquine was slightly but consistently more effective than quinine in this role. this finding provides support for use of chloroquine as the companion blood schizonticide in the current experimental animal-based search for improved tissue schizon ... | 1981 | 7212167 |
| cultivation in vitro of the vivax-type malaria parasite plasmodium cynomolgi. | the vivax-type simian malaria parasite plasmodium cynomologi was cultured in vitro by both the candle jar method and the continuous flow technique, with rhesus monkey erythrocytes and rpmi 1640 medium supplemented with hepes buffer and human serum. after 6 weeks in culture, the growth of the parasite had permitted a 5 x 10(6) cumulative dilution of the original inoculum. cultured parasites remained infective to rhesus monkeys and exhibited a reversible decrease in the ameboid behavior of their t ... | 1981 | 7233207 |
| evolutionary relatedness of some primate models of plasmodium. | primate--and, specifically, monkey--malaria infections are commonly used for understanding the pathology of and immune response to the human disease because they are thought to resemble most closely the host-parasite relationship found in humans. plasmodium cynomolgi is used extensively as a model for the human parasite, p. vivax, and p. knowlesi is used primarily as a model for the development of erythrocytic-stage vaccines. both of these simian parasites can naturally infect man, resulting in ... | 1993 | 7689135 |
| use of the rhesus monkey as an experimental model to test the degree of efficacy of an anti-sporozoite peptide malaria vaccine candidate combined with copolymer-based adjuvants. | humoral response against sporozoites is not effective in protecting individuals from getting malaria. reduction in the infectivity of sporozoites has not been quantified for most anti-sporozoite vaccines tested. quantification requires animal models providing predictable prepatent periods, e.g., time elapsed between sporozoite inoculation and detection of parasitemia, to be used as an indicator of activity against sporozoites. a delay in prepatent period from vaccinated animals would therefore r ... | 1995 | 7741171 |
| immunologic characterization of plasmodium vivax antigens using plasmodium cynomolgi liver stage-primed immune sera. | we have shown in a previous study that immunization of a rhesus monkey (macaca mulatta) with inactivated liver stages of the simian malaria parasite plasmodium cynomolgi (b strain) produced high antibody titers against sporozoites, liver stages, and blood stages of p. cynomolgi. in the present study, we demonstrate that these anti-p. cynomolgi immune sera recognized p. vivax (salvador i) antigens. in an indirect immunofluorescence assay, both postimmunization and postchallenge sera reacted with ... | 1994 | 7943558 |
| the small ribosomal subunit rna isoforms in plasmodium cynomolgi. | we report the isolation, characterization and analysis of the small subunit rrna genes in plasmodium cynomolgi (ceylon). as in other plasmodium species, these genes are present in low copy number, are unlinked and form two types that are distinct in sequence and are expressed stage specifically. the asexually expressed (type a) genes are present in four copies in the ceylon- and in five copies in the berok-strain. surprisingly, the sexually expressed (type b) gene is present in a single copy. th ... | 1994 | 8005440 |
| removal of leucocytes from plasmodium vivax-infected blood. | 1994 | 8067817 | |
| [studies on the establishment of malarial animal model of short-term relapse. iv. short-term relapse in rhesus monkeys infected with sporozoites of plasmodium cynomolgi]. | the present paper reports that the short-term relapse could be artificially made by the application of the experimental method, and thus we established the monkey model of the short-term relapse. according to the experimental design, when the parasitemia was detected in rhesus monkeys infected with sporozoites of plasmodium cynomolgi, a combined therapy of pyronaridine 6 mg/kg body weight, artemether 10 mg/kg and chloroquine 20 mg/kg once daily for 3 days was carried out to clear the erythrocyti ... | 1993 | 8082260 |
| [progress on the study of the distribution of plasmodium cynomolgi in the world]. | 1994 | 8082460 | |
| evaluation of wr250417 (a proguanil analog) for causal prophylactic activity in the plasmodium cynomolgi-macaca mulatta model. | the plasmodium cynomolgi-macaca mulatta model has been used to test the antimalarial activity of new drugs for both radical cure and casual prophylaxis. the proguanil analog wr250417 (also known as ps-15) was evaluated for causal prophylactic activity in rhesus monkeys infected with p. cynomolgi bastianelli. four monkeys were orally dosed with 40 mg/kg/day of wr250417 over three days (-1, 0, and +1). sporozoite-induced infection of p. cynomolgi was initiated on day 0 with 1 x 10(6) sporozoites t ... | 1994 | 8116810 |
| [studies on the establishment of malarial animal model of short-term relapse. iii. combined therapy with pyronaridine-artemether-chloroquine for parasitemia clearance]. | to establish a plasmodium cynomolgi-monkey model of short-term relapse, different antimalarials have been used to inhibit recrudescence so as to elude the confusion between the two different onsets. when a single dose of effective schizonticides pyronaridine, artemether or chloroquine was administered, recrudesence readily occurred. this paper reports the results of the combined therapy with the above three drugs. seven rhesus monkeys from guangxi autonomous region infected with plasmodium cynom ... | 1993 | 8168239 |
| [studies on residual antimalarial activity of tripynadine in mice and monkeys]. | this paper reports the experiments in which tripynadine free base at a dose 4.5 times that of ed50 was given to mice by intragastric administration. on the 20th day following the administration the mice were inoculated with 1 x 10(7) rbc infected with plasmodium berghei anka strain. the infection rate was zero, implying that all mice had acquired protection. although the residual activity time of tripynadine phosphate was longer than that of tripynadine free base or piperaquine phosphate, but tr ... | 1993 | 8168241 |
| role of fatty infiltration during malaria in rhesus monkey. | p. cynomolgi b-rhesus monkey model of malarial infection has been used to study lipid infiltration in host tissues in early (exoerythrocytic) and late (chronic) stages of malaria infection. histochemically we could demonstrate significant infiltration of neutral & total lipids in liver during the exoerythrocytic stage and in liver and kidney in the erythrocytic stage. the parasite used in the study closely resembles the human parasite p. vivax. it has a defined prepatent period, can be cyclicall ... | 1994 | 8196503 |
| proguanil plus sulfamethoxazole is not causally prophylactic in the macaca mulatta--plasmodium cynomolgi model. | new drugs for causal prophylaxis of malaria are needed. a proguanil/sulfamethoxazole combination was investigated using a rhesus monkey model (macaca mulatta infected with plasmodium cynomolgi) to determine whether causal prophylaxis could be achieved. when a five-day regimen of proguanil (40 mg/kg/day) combined with sulfamethoxazole (100 mg/kg/day) was used, infection of all animals (6 of 6) was observed, with an extended prepatent period (median 40 days). two control animals became infected on ... | 1994 | 8203715 |
| causal prophylactic and radical curative activity of wr182393 (a guanylhydrazone) against plasmodium cynomolgi in macaca mulatta. | primaquine is the only currently available drug effective against persistent tissue stages of relapsing malaria in humans. causal prophylactic and radical curative properties of wr182393 (a guanylhydrazone) were investigated as part of an effort to evaluate alternatives to primaquine in the rhesus monkey (macaca mulatta)/plasmodium cynomolgi test model. the drug was suspended in dimethylsulfoxide for intramuscular (im) injection. a pilot study indicated causal prophylactic activity in a regimen ... | 1993 | 8214277 |
| association of two esterase genes, a chromosomal inversion, and susceptibility to plasmodium cynomolgi in the african malaria vector anopheles gambiae. | the ability of a selected strain of the malaria vector anopheles gambiae to encapsulate the early oocysts of the malaria parasite plasmodium cynomolgi b has previously been shown to be genetically linked to specific esterase phenotypes. this association between plasmodium susceptibility and esterase phenotype is found in the an. gambiae g3 strain from which the plasmodium-refractory and -susceptible mosquito strains were derived. genetic crosses had suggested that the esterase phenotypes reflect ... | 1993 | 8372956 |
| hydrolytic enzymes of rhesus placenta during plasmodium cynomolgi infection: ultrastructural and biochemical studies. | placenta in monkey demonstrated altered pathophysiology after p cynomolgi infection. the electronmicroscopic observations showed slight complete focal necrosis of the placental tissue, besides alterations in total protein, phosphatases and proteinases. these changes in cellular constituents of placenta during malaria infection may be responsible for malfunctioning of the organ and in turn, abnormal development of foetus. | 1993 | 8500817 |
| sequence analysis of apical membrane antigen 1 (ama-1) of plasmodium cynomolgi bastianelli. | 1995 | 8577338 |