| the action of metabolic inhibitors on microgametogenesis in plasmodium yoelii nigeriensis. | mature gametocytes of plasmodium yoelii nigeriensis were incubated in vitro with a variety of antibiotics whose activities were directed against dna, rna, protein and microtubule assembly. following incubation for periods between 5 and 90 min, exflagellation was induced and the degree of inhibition produced by each drug was assayed microscopically. the results obtained show that de novo synthesis of axonemes and proteins is essential to the events of microgametogenesis. the inhibitory effect of ... | 1977 | 919692 |
| the distribution, incidence and general ecology of saurian malaria in middle america. | | 1977 | 924716 |
| structure of aplasmomycin. | a new antibiotic, aplasmomycin, was isolated from a broth cultivated with a marine isolate of actinomycete, and inhibits gram-positive bacteria in vitro and plasmodium berghei in vivo. it is a natural ionophore and the structure of the ag-salt was solved by an x-ray crystallographic analysis. it has symmetric structure having boron in the centre of the molecule. | 1977 | 924893 |
| intra-erythrocytic death of the parasite in mice recovering from infection with babesia microti. | as mice recover from infection with babesia microti, abnormal forms of the parasite are present in some red cells. these forms are non-infective, indistinguishable by light microscopy from those present after treatment with amicarbalide, a babesicidal drug, and persist in splenectomized mice. electron microscopy confirmed that these abnormal forms are degenerating intra-erythrocytic parasites. in the absence of evidence for death of b. microti elsewhere in the body, it appears that infections of ... | 1977 | 927888 |
| algorithms in the diagnosis and management of exotic diseases. xiii. malaria. | | 1976 | 932498 |
| conformational changes induced in plasmodium actin polymer by ca2+ in the presence of muscle native tropomysin. | the flexible polymer of plasmodium actin (mg-polymer) combines with muscle native tropomyosin up to a weight ratio of actin: tropomyosin:troponin = 6:1:1. mg-polymer which combined with muscle native tropomyosin undergoes a conformational change when the ca2+ concentration of the solution is decreased by adding 0.5 mm ethylene glycol bis(beta-aminoethylether)-n,n'-tetraacetic acid (egta): the viscosity of the solution increases by 50% and its atpase activity decreases to about 20% of the origina ... | 1976 | 932566 |
| feeding mechanisms in extracellular babesia microti and plasmodium lophurae. | although large hemoglobin inclusions are observed in intraerythrocytic babesia microti parasites, they are absent from parasites freed of hamster red cells by immune lysis with anti-hamster erythrocyte serum. babesia microti has no cytostome. this parasite, therefore, does not appear to feed by phagocytosis of large boluses of hemoglobin, as does plasmodium. to determine whether babesia can pinocytose protein, free parasites were fed ferritin in an in vitro system. ferritin was taken up from the ... | 1976 | 933077 |
| does a histidine-rich protein from plasmodium lophurae have a function in merozoite penetration? | autoradiography was used to localize the distribution of l-[3h]histidine incorporated in vitro by developing segmenters of plasmodium lophurae. under conditions used for the visualization of high specific activity loci, radioactivity appeared associated mainly with the histidine-rich protein of cytoplasmic granules as well as with rhoptries and micronemes of merozoites. the isolated histidine-rich protein caused agglutination of erythrocytes and increased their osmotic fragility. based on the o ... | 1976 | 933084 |
| genetics of chloroquine resistance in malaria parasites. | | 1976 | 934297 |
| synthesis of ribosomal rna during the mitotic cycle on the slime mould physarum polycephalum. | 1. an isotope dilution technique has been used to analyze the synthesis of metabolically stable nucleic acids during the mitotic cycle in surface plasmodia of the slime mould physarum polycephalum. microplasmodia that had been labelled with [3h]uridine were used to prepare a surface culture, after a period of growth long enough to ensure that radioactivity was present only in trna, rrna and dna. the synthesis of rrna or nuclear dna during the growth of the surface plasmodium was then followed by ... | 1976 | 944125 |
| actomyosin content of physarum plasmodia and detection of immunological cross-reactions with myosins from related species. | the content of myosin in plasmodia of the myxomycete physarum polycephalum was measured by an immunological technique, quantitative microcomplement (c') fixation. migrating plasmodia (starved after growth on rolled oats) contained 0.60 +/- 0.08 (sd) mg myosin per g fresh plasmodia. myosin comprised 0.77% +/- 0.05 (sd) of the total plasmodial protein. when total plasmodial proteins were separated by electrophoresis on sds-polyacrylamide gels, a large amount of protein appeared in a band comigrati ... | 1976 | 944188 |
| beta-actinin-like protein from plasmodium. | a beta-actinin-like protein was isolated from plasmodia of the slime mold. the chain weight was the same as that of actin (43,000), but the amino acid composition was significantly different. the action of plasmodium beta-actinin on actin was the same as that of beta-actinin from rabbit skeletal muscle: inhibition of the recombination of f-actin fragments; formation of mg polymer; inhibition of interfilamental interaction of f-actin and retardation of depolymerization of f-actin. the only differ ... | 1976 | 945265 |
| parasitology survey in northern sumatra, indonesia. | a parasitology survey was conducted in five villages in north sumatra, indonesia. a total of 3,207 blood smears, 2,066 stool specimens and 969 sera were examined. sixty (1.9%) inhabitants had malaria (plasmodium vivax 41, p. falciparum 19), and 20 had brugia malayi microfilaraemia. the most common intestinal helminths were trichuris trichiura (87%), ascaris lumbricoides (75%) and hookworm (58%). other helminths found in low numbers were enterobius vermicularis, strongyloides stercoralis, taenia ... | 1976 | 950682 |
| plasmodium (giovannolaia) pedioecetii from gallinaceous birds of colorado. | forty-nine colorado birds of 6 galliform species were positive for plasmodium (giovannolaia) pedioecetii which we feel to be the same parasite described by wetmore (1939) from a shaptailed grouse from north dakota. except for its presence in darwin's tinamou (nothura darwinii) from colorado, it has been reported only from gallinaceous birds. most stages were predominantly subpolar to polar. there were a daily 8 am to noon peak of merozoite production, but no synchronicity. merozoite number range ... | 1976 | 957032 |
| restoration of cell morphology after culture of malarial parasites in vitro. | | 1976 | 957043 |
| successful immunization against the sexual stages of plasmodium gallinaceum. | gametocyte infectivity and oocyst development of the avian malaria parasite, plasmodium gallinaceum, can be reduced or eliminated in mosquitoes by immunizing the chickens on which the mosquitoes feed with infected red blood cells that have been treated with formalin or x-rays. protection of the mosquito appears to be related to the immobilization of the microgametes in its gut and is associated with the immunoglobulin g fraction of serum. | 1976 | 959832 |
| effect of host infection with plasmodium gallinaceum on the reproductive capacity of aedes aegypti. | | 1976 | 965781 |
| fluorescence study of n-(3-pyrene)maleimide conjugated to rabbit skeletal f-actin and plasmodium actin polymers. | a fluorescent probe n-(3-pyrene)maleimide was conjugated to rabbit skeletal f-actin at the site of most reactive sulfhydryl group (cys-373). its fluorescence anisotropy decay showed a single correlation time of 560 ns at 25 degrees c, which is in a very good agreement with the correlation time of the dansyl-l-cysteine group conjugated to the same site of f-actin reported very recently [wahl, ph., mihashi, k, and auchet, j-c. (1975) febs lett. 8, 164-167]. actin from plasmodia of myxomycates, phy ... | 1976 | 974110 |
| [prevention of post-transfusional malaria by sero-detection of latent plasmodium carriers among blood donors]. | the risks of post-transfusion malaria are becoming a worry and the sero-investigation of latent carriers of plasmodium, among donors, is certainly the only efficient prophylactic measure. this is the result of an investigation carried out between october 1973 and february 1975 in 18 blood tranfusion centres in france. out of 2.997 sera studied in immuno-fluorescence of malaria, 3 to 5.2% of sero-positivity have been noticed, depending on the antigen used (p. falciparum, p. malariae and p. cynomo ... | 1976 | 981873 |
| [results of a survey on post-transfusional malaria in france between 1960 and 1974]. | this inquire demonstrated that transfusion malaria was not so rare as we thought. so 56 cases have been numbered between 1960 and 1974, and probably they do not reflect exactly the real situation. in our country, plasmodium falciparum, specifically responsible of the most serious accidents, is the form most frequently incriminated and its frequency increases among the years: 76,1% of the infects between 1970 and 1974. at last we have confirmed that a prevent of those accidents must consider as a ... | 1976 | 981874 |
| [trial serologic detection of plasmodium carriers among blood donors of the centre de transfusion sanguine de marseiile]. | this paper is a survey of possible reservoir hosts of plasmodium among donors of the blood transfusion center of marseille, by ifa test with p. falciparum and p. cynomolgi bastianellii antigens. it was found 15,7 per cent of positivity among 644 sera carefully selected during 6 months. nord africa and west africa were the most dangerous countries, the former because of the great number of donors (332 of 744), the later because of the high rate (15,8 per cent) of positivity. the incidence of the ... | 1976 | 981875 |
| ferrokinetics in patients with malaria: haemoglobin synthesis and normoblasts in vitro. | bone marrow cultures in 15 plasmodium falciparum patients were studied both during and after parasitaemia. abnormalities were observed only in the group during parasitaemia. these abnormalities included: (1) decreased normoblastic number and cellular iron incorporation in all cases; (2) premature death of normoblasts during their development in the cultures in all cases; (3) defective haemoglobin synthesis in 3 of 11 cases (27%). a causal relationship between defective haemoglobin synthesis and ... | 1976 | 982520 |
| [structural and enzyme-histochemical changes of villous trophoblast during pregnancy]. | a critical examination of chorion epithel of terminal villi is made on 80 placentas between 8 and 28 as well as 37 and 41 weeks of gestation after a normal pregnancy (clinical and anamnestical) with structural (carbohydrates, albumines, nucleid-acids) and enzymhistochemical methods. the results of reactions signifies an incontinual morphological and functional differentiation of trophoblast between 16 and 28 weeks. the reduction of langhanscells and transformation of their predominant degree of ... | 1976 | 983488 |
| malaria transmission blocked by immunisation with gametes of the malaria parasite. | | 1976 | 986561 |
| [characteristics of the genus glugea (protozoa, microsporidia) based on the example of the type species glugea anomala (moniez, 1887) gurley 1893 and its varieties]. | a study of the life cycles of some varieties of glugea anomala has shown that the genus glugea is a distinct genus having the following diagnosis. sporoblasts and spores are formed as a result of step by step decay of the multinuclear plasmodium situated inside the sporogonal vacuole (sporont). ripe spores either remain connected together in groups with irregular (6 to 32) often uneven number of spores of lie singly, seldom in pairs. microsporidia are able to cause extremely strong hypertrophy o ... | 1976 | 989168 |
| immune complex extracted from acutely infected malarious chicken kidneys: physico-chemical properties of antigen part. | | 1976 | 992848 |
| ultrastructure of interlamellar henneguya exilis in the channel catfish. | ultrastructural aspects of interlamellar henneguya exilis infections in channel catfish are reported. the plasmodium wall of this form differs from that of other species in that it is composed of two outer unit membranes which give rise to a zone of numerous pinocytic canals. single-membraned canals appeared to be a stable feature of the wall while double-membraned canals are interpreted as those actively carrying out pinocytosis. evidence suggests that host cellular cytoplasm as well as interst ... | 1976 | 1003287 |
| designations of strains of parasitic protozoa. | | 1976 | 1006769 |
| morbidity from schistosoma mansoni infections: an epidemiologic study based on quantitative analysis of egg excretion in two highland ethiopian villages. | although human infection with schistosoma mansoni is known to be widespread in highland ethiopia, no information is available on its public health impact. a sample of the inhabitants of two typical villages in the endemic region north of lake tana were studied by clinical and quantitative parasitologic methods. one village had a moderately high prevalence (43.3%), while the second, chosen for comparison, had a very low prevalence (10.7%). no evidence of severe hepatosplenic disease was found in ... | 1976 | 1008126 |
| [case report. presumption of transfusion malaria]. | | 1976 | 1021879 |
| parasitological survey in gorontalo north sulawesi, indonesia. | a survey for blood and intestinal parasites was carried out in the municipality of gorontalo on the minahasa peninsula of north sulawesi. a total of 156 stool specimens were obtained from 83 males and 73 females. trichuris trichiura, ascaris lumbricoides, hookworm, unidentified dicrocoeliid-like ova and entamoeba coli, in that order, were the most common intestinal parasites detected. other intestinal parasites found less frequently were entamoeba histolytica, iodamoeba bütschlii, endolimax nan ... | 1976 | 1030844 |
| coezyme a requirement of malaria parasites: effects of coenzyme a precursors on extracellular development in vitro of plasmodium lophurae. | the extracellular development in vitro of the avian malaria plasmodium lophurae is favored by addition to the medium of coenzyme a at 0.05 mm. coenzyme a can be replaced by dephospho-coenzyme a and to some extent by phosphopantetheine, but not by phosphopantothenoylcysteine or by phosphopantothenic acid. the activity of the two former precursors results from their conversion to coenzyme a by enzymes in the erythrocyte extract of the culture medium in the presence of atp, also an essential ingred ... | 1975 | 1057772 |
| on primary structure and biosynthesis of histidine-rich polypeptide from malarial parasite plasmodium lophurae. | experiments on the primary structure of a histidine-rich polypeptide isolated from the malarial parasite plasmodium lophurae indicate that the smaller quantities of amino acids other than histidine form an integral part of the polypeptide and do not arise from a protein contaminating a histidine homopolymer. in culture, the parasites incorporate over 50% of exogenously supplied histidine into the histidine-rich polypeptide and this incorporation is inhibited by puromycin. | 1975 | 1059091 |
| malaria complicating neoplastic disease. | two patients with neoplastic disease had transfusion-induced malaria. in a patient with acute myelogenous leukemia infected with plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection. in a splenectomized patient with metastatic carcinoma of the colon, p malariae infection was associated with a fulminant course simulating cerebral malaria. despite delay in diagnosis, both patients responded drama ... | 1976 | 1065254 |
| photoreceptor pigment that induces differentiation in the slime mold physarum polycephalum. | an extract of small molecules (molecular weight less than 500) of the slime mold physarum polycephalum undergoes a shift in ultraviolet-visible absorption spectrum upon illumination. this illumination also confers on the extract the ability to induce sporulation when injected into a starved, unilluminated slime mold. the spectral shift and appearance of the sporulation-inducing activity both occur regardless of whether the illumination is carried out on an intact slime mold or on the plasmodium- ... | 1976 | 1069274 |
| nonsterilizing immunity in avian malaria: an antibody-independent phenomenon. | agammaglobulinemic chickens died with fulminating parasitemias following infection with p. gallinaceum. when rescued from otherwise fatal infection by means of chloroquine therapy, b-cell deficient chickens resisted challenge infection with the same parasite. the data suggest that nonsterilizing immunity to malaria in chickens is b-cell independent. | 1976 | 1082596 |
| immunopathology of nephropathies associated with malaria. | immune complexes play an important role in the pathogenesis of malaria-associated nephropathies. two main types of lesion are demonstrable: (a) acute (transient-reversible) lesions typical of falciparum infections in man, with mild clinical symptoms developing a week or two after infection. renal biopsies at that time show deposits of immunoglobulins, complement, and sometimes antigen. the lesions respond to antimalarials. (b) chronic (progressive) lesions characteristic of quartan infections in ... | 1975 | 1083308 |
| parasite cultivation in relation to research on the chemotherapy of malaria. | attempts to develop techniques for the continuous in vitro cultivation of the malaria parasite have not yet proved successful. it has not been possible to obtain the complete sporogonic development of the parasite in vitro although some progress was made with plasmodium relictum and p. berghei. exoerythrocytic stages of p. gallinaceum have been successfully cultivated in vitro in tissue explants and those of p. fallax have been grown in turkey primary embryo tissue cells. with the recent develop ... | 1976 | 1086733 |
| serum complement and immunity in experimental simian malaria. i. cyclical alterations in c4 related to schizont rupture. | previous studies indicated that the level of whole serum complement (c') falls during malaria, and that the fall in c' is linked to schizont rupture and the appearance of humoral antibody. for a more detailed study of the role of c' in malaria, levels of c4 were monitored in rhesus monkeys infected with plasmodium coatneyi. after one to two weeks of infection, significant and abrupt declines in c4 levels occurred, and these were temporally related to the process of schizont rupture. the level of ... | 1975 | 1089126 |
| investigation of the evi antibody in parasitic diseases other than american trypanosomiasis. an anti-skeletal muscle antibody in leishmaniasis. | the specificity of a circulating antibody observed in american trypanosomiasis and reacting with endocardium, blood vessels, and the interstitium of striated muscle (evi factor) was evaluated in the indirect fluorescent antibody test with 60 sera from patients with malaria, leishmaniasis, echinococcosis, amebiasis, african trypanosomiasis, toxoplasmosis, and trichinosis, collected from areas where chagas' disease is not endemic. two sera, 1 from a patient with plasmodium falciparum malaria and 1 ... | 1975 | 1089366 |
| inhibition of macromolecular synthesis in the malarial parasites by inhibitors of proteolytic enzymes. | | 1975 | 1089545 |
| motility of plasmodium berghei ookinetes in vitro. | | 1975 | 1089734 |
| host failure in treatment of malaria with sulfalene and pyrimethamine. | an individual infected with a multidrug-resistant strain of plasmodium falciparum failed to respond to treatment with sulfalene and pyrimethamine. subinoculation studies showed that parasite resistance to the drug combination was not present. plasma levels of sulfalene and pyrimethamine in this individual were similar to those of three individuals, subinoculated from him, who were cured by the drug combination. erythrocyte levels of sulfalene in this individual were similar to those in an indivi ... | 1975 | 1090224 |
| letter: unexplained fever. | | 1975 | 1090330 |
| plasmodium gallinaceum: avian immunologic tolerance to serum antigens. | | 1975 | 1090439 |
| plasmodium berghei: thyroid hyperplasia and thyroid hyperactivity in mice. | | 1975 | 1090441 |
| regional immunosuppression induced by plasmodium berghei yoelii infection in mice. | plasmodium berghei yoelii infection in mice severely depressed the splenic antibody response to sheep erythrocytes but had lettle effect on antibody formation in lymph nodes. | 1975 | 1090525 |
| the in vitro culture of the blood stages of plasmodium berghei. | | 1975 | 1090550 |
| humoral immunity in rodent malaria. iii: studies on the site of antibody action. | serum which protects rats against plasmodium berghei infections fails to sensitize parasitized erythrocytes in vitro for in vivo destruction. further, the efflux of 86rb from parasitized erythrocytes in the presence of complement is not accelerated. on administration to animals with preexisting malaria, it does, however, produce a relatively slow decline in parasitemia, a phenomenon interpreted in terms of the gradual production and/or release of reactive antigenic determinants associated with m ... | 1975 | 1090670 |
| development of infectivity by the plasmodium berghei sporozoite. | studies were done on the development of infectivity during ontogeny of the sporozoite of the rodent malaria parasite, plasmodium berghei. populations of sporozoites were separated from the oocysts, the hemocoel, and the salivary glands, with special precautions being taken to avoid cross-contamination between the different populations. the results indicated that populations of salivary gland sporozoites were more than 10,000 times as infective as populations of oocyst sporozoites from the same m ... | 1975 | 1090717 |
| the prevalence and relationships of malaria, anemia, and malnutrition in a coastal area of el salvador. | to study the relationships between malaria, anemia and malnutrition, 853 school-age children from a high malaria incidence area and an adjacent low incidence area were surveyed in september 1972. for the high incidence area the malaria slide positivity rate was 3.5%, spleen rate 7.6% and malaria (indirect fluorescent antibody) serology positivity 24.7%. contrasted to this, no positive slides, only 3 palpable spleens and a 3.4% serology positivity rate were found for the low incidence area. twent ... | 1975 | 1091165 |
| rodent systems (plasmodium berghei-anopheles stephensi) for screening compounds for potential causal prophylaxis. | an in vivo screening system is described in which drugs administered to rats or mice and challenged with sporozoites are evaluated for their antimalarial properties (causal prophylaxis, suppression, therapy) by the presence or absence of exoerythrocytic forms and parasitemia. the system is composed of a/j mice, sprague-dawley rats, plasmodium berghei, and anopheles stephensi. good correlation has been found between test results and practical application. | 1975 | 1091166 |
| a prospective study of the effects of ultralow volume (ulv) aerial application of malathion on epidemic plasmodium falciparum malaria. i. study design and perspective. | a large-scale prospective study was designed to test the effects of aerial ultralow volume (ulv) application of malathion on epidemic plasmodium falciparum malaria. the study was conducted during 1972 to 1973, in the miragoane valley of haiti, an area having annual anticipated outbreaks of malaria, which allowed prospective assessment. spraying of malathion at a dosage of 4.5 fluid ounces per acre reduced populations of adult anopheles albimanus to less than 1% of prespray levels and interrupted ... | 1975 | 1091167 |
| a prospective study of the effects of ultralow volume (ulv) aerial application of malathion on epidemic plasmodium falciparum malaria. ii. entomologic and operational aspects. | in a large-scale study in the miragoane valley of haiti, designed to test the effects of aerial ultralow volume (ulv) malathion on epidemic plasmodium falciparum malaria, spray operations resulted in an immediate and sharp decline in numbers of the vector, anopheles albimanus. the adult population of this mosquito remained at less than 1% of previous levels until several weeks after a 50-day spray period (27 october-16 december 1972) during which six cycles were completed. the study area offered ... | 1975 | 1091168 |
| a prospective study of the effects of ultralow volume (ulv) aerial application of malathion on epidemic plasmodium falciparum malaria. iii. ecologic aspects. | the effects of aerial ultralow volume (ulv) malathion on selected species of nontarget animals in haiti are reported. mortality of certain groups of insects such as bees, flies, beetles, and butterflies was observed immediately following spray application. minor fish mortality occurred only in shallow water exposed to direct spray. the brain acetylcholine esterase levels of living fish, tree lizards, birds and bats collected from treated areas were not significantly reduced. no ill or dead anima ... | 1975 | 1091169 |
| a prospective study of the effects of ultralow volume (ulv) aerial application of malathion on epidemic plasmodium falciparum malaria. iv. epidemiologic aspects. | in the miragoane valley of haiti a consistent pattern in the incidence of plasmodium falciparum malaria over a 10-year period made it possible to predict an annual outbreak and perform a prospective study to test the effects of aerial ultralow volume (ulv) malathion on epidemic levels of this disease. at the end of october 1972, after epidemic levels (100 cases/month/10,000 population) had been reached, spray operations were begun. the first spray cycle produced a sharp and immediate drop in pop ... | 1975 | 1091170 |
| antimalarial effects of clindamycin in man. | clindamycin 450 mg every 8 hours for 3 days cured three non-immune patients of falciparum malaria, although the response was slow. the addition of quinine to this regimen provided an accelerated response and cured 3 of 5 other patients. single doses of clindamycin given daily for 3 days, with or without quinine, cured 1 of 3 patients. gastric intolerance to the drugs, probably accentuated by the clinical condition, was pronounced in some cases, the course of treatment being interrupted in three ... | 1975 | 1091172 |
| letter: prevention of chloroquine-resistant falciparum malaria. | | 1975 | 1091190 |
| detailed purine salvage metabolism in and outside the free malarial parasite. | | 1975 | 1091492 |
| qualitative analysis of phospholipids isolated from nonviable plasmodium antigen. | | 1975 | 1091493 |
| [demonstration of chloroquine diphosphate resistance in plasmodium falciparum strains naturally infecting man in an area of the bolivar state, venezuela]. | | 1975 | 1091958 |
| suppression of malaria with monthly administration of combined sulphadoxine and pyrimethamine. | a trial of suppression of malaria by administration of combined sulphadoxine-pyrimethamine tablets every 28 days was undertaken in west malaysia during 1972. one thousand subjects were followed over a 10-month period, including control groups on placebo and on weekly chloroquine. subjects were examined monthly for parasitaemia, drug reactions, leucopenia, teratogenicity and haemolysis among the subjects deficient in glucose-6-phosphate dehydrogenase. rates of new infections in the placebo group ... | 1975 | 1092276 |
| chloroquine-resistant falciparum malaria from west irian and east kalimantan. | | 1975 | 1092277 |
| new serological test for malaria antibodies. | in an enzyme-linked immunosorbent assay test for malaria antibodies, antibodies to plasmodium vivax and p. falciparum in man are detected using a crude antigen prepared from the simian malaria parasite p. knowlesi. the test may be suitable for epidemiological studies. | 1975 | 1092412 |
| a new prodiginne (prodigiosin-like) pigment from streptomyces. antimalarial activity of several prodiginnes. | two prodigiosin-like pigments from streptomyces sp. were shown to be undecylprodiginine (i) and butylcycloheptylprodiginine (v). the antimalarial activity of five prodiginine pigments is given. | 1975 | 1092639 |
| effects of red cell extract on in vitro growth and multiplication of malarial parasites. | an extract of red blood cells was prepared from monkey blood. red cell extract (rce) of aotus monkeys was beneficial for the in-vitro cultivation of 2 strains of p. falciparum. the active material(s) in aotus rce was not sedimented by centrifugation at 34,800 g for 1 hr. rhesus monkey rce improved the growth of p. knowlesi for in-vitro cultivation through 4 schizogonous cycles (88 hr). | 1975 | 1092828 |
| synthesis and antimalarial activity of heterocyclic alkyl disulfides, thiosulfates, and dithio acid derivatives. | based on the antimalarial activity in mice of bis(4-rho-acetamidobenzenesulfonamidophenyl) disulfide, a series of n-heterocyclic alkyl disulfides and thiosulfates was synthesized and screened for antimalarial activity. several related dithio acid dianions and s- blocked derivatives were also screened to provide an indication of the possible role that thiol anions might play in malaria chemotherapy. activity was limited by toxicity with these compounds, and none of those tested, with the exceptio ... | 1975 | 1092835 |
| a model of how the sickle-cell gene produces malaria resistance. | | 1975 | 1092922 |
| immunosuppressive effects of experimental infection with plasmodium gallinaceum. | experimental infection of chickens with p. gallinaceum mardedly suppressed the splenic pfc response to srbc. suppression was most pronounced when birds were immunized at the time of peak parasitemia. the pfc response to e. coli lps was of low magnitiude in both normal and infected chickens; however, it, too, was suppressed in infected birds, but not to the same degree as observed in response to srbc. cellular immunity as evidenced by allograft rejection was not influenced by infection. | 1975 | 1093192 |
| falciparum malaria semi-resistant to clindamycin. | clindamycin, a semi-synthetic antibiotic of the lincomycin family, at a dose of 450 mg eight-hourly for three days in adults cured five out of 10 patients moderately ill with chloroquine-resistant falciparum malaria. combination therapy with full-dose quinine and clindamycin for three days cured all four patients so treated who were followed up, and with half dosage three out of five patients were cured. both combinations, however, caused upper gastrointestinal toxicity and appeared to potentiat ... | 1975 | 1093609 |
| falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine. | quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose of sulfadoxine-pyrimethamine (fansidar) is the most effective treatment of chloroquine-resistant falciparum malaria. this regimen cured 96% of patients (302 out of 314) with an average initial parasite count of 90 x 10-9/1. | 1975 | 1093610 |
| letter: treatment of falciparum malaria. | | 1975 | 1093620 |
| editorial: a final curtain. | | 1975 | 1093624 |
| synthesis and evaluation of 6-arylactamido-2,4-diaminoquinazolines and related compounds as folic acid antagonists. | a series of 2,4-diaminoquinazolines bearing an aryl function attached to the 6 position through an acetamido or related linkage was synthesized. each compound was evaluated as an inhibitor of rat liver dihydrofolate reductase as well as for suppressive antimalarial effects against plasmodium berghei in mice. significant in vivo activity was found to reside primarily with 5-chloro-6-arylacetamido derivatives. most of these compounds were also tested for prophylactic activity against sporozoite-in ... | 1975 | 1094114 |
| sulfadoxine and pyrimethamine in the treatment of falciparum malaria in vietnam. | | 1975 | 1094249 |
| malaria and its control in iran. | | 1975 | 1094644 |
| circadian and other rhythms of parasites. | | 1975 | 1094812 |
| "topical nephropathy" and "tropical extramembranous glomerulonephritis" of unknown aetiology in senegal. | a study of renal biopsy specimens obtained in senegal from 24 children and six adults with nephrotic syndrome showed two unusual varieties of nephropathy--namely, an extramembranous glomerulonephritis associated with hypocomplementaemia (four cases), a combination previously described only in systemic lupus erythematosus, and a "tropical nephropathy" (16 cases). the latter, though lacking the diffuse glomerular deposits of immunoglobulin described in quartan malarial nephropathy (q.m.n.), showed ... | 1975 | 1095112 |
| cerebral malaria. | cerebral malaria is an acute diffuse encephalopathy associated only with plasmodium falciparum. it is probably a consequence of the rapid proliferation of the parasites in the body of man in relation to red cell invasion, and results in stagnation of blood flow in cerebralcapillaries with thromobotic occlusion of large numbers of cerebral capillaries. the subsequent cerebral pathology is cerebral infarction with haemorrhage and cerebral oedema. the wide prevalence of p. falciparum in highly ende ... | 1975 | 1095294 |
| splenic mediated erythrocyte cytotoxicity in malaria. | cell-mediated cytotoxicity in virulent rodent malaria has been demonstrated in vitro, whereby splenic cells effected specific lysis of 51cr-labelled erythrocytes from parasitized animals. more than one cellular cytolytic effector system appeared to be operative in the mouse. one effector system involved splenic macrophages, from normal or immune animals, which were increasingly cytotoxic to target cells in the presence of antibody. a second effector system involved nylonpurified immune spleen ce ... | 1975 | 1095474 |
| chloroquine resistant malaria in west malaysia. | chloroquine resistance is a well established entity in south east asia, and presents a problem of increasing importance. strains of p. falciparum resistant to chloroquine have also been found to be resistant to amodiaquine and a combination of pyrimethamine and sulphadoxine. knowledge of the drug sensitivity of the strains of malaria parasite in a given locality is important so that the right choice of drugs can be made in treatment of the disease. the treatment of chloroquine resistant malaria ... | 1975 | 1095776 |
| antimalarial compounds. xiii. new derivatives of phenyl chloromethyl sulfone. | a series of chloromethylsulfonyl derivatives of amines, biguanides and amidineureas (scheme 1) has been prepared and their antimalarial properties investigated. | 1975 | 1096101 |
| antimalarial compounds. xiv. new derivatives of 2-bromo-n,n-bis-(diethylaminoethyl)-4,5-dimethoxyanaline (rc 12). | the molecule of rc 12 which was found previously to exhibit antimalarial activity has been modified, by replacing groups in positions 1 and 2 by nhar, s-ar, no2, sulfonamido and other substituents. the new derivatives (table 1) were tested for toxicity and antimalarial activity agains plasmodium berghei in mice (table 2). | 1975 | 1096102 |
| studies on coagulation and fibrinolysis in cases of falciparum malaria. | coagulation and fibrinolytic studies were conducted in 18 cases of severe falciparum malaria including cases with parasitaemia above 5% and with pernicious manifestations such as coma, jaundice, anuria, pulmonary oedema, bleeding tendency, etc., irrespective of parasitaemia. marked changes in blood coagulograms and high levels of serum fibrin degradation products appeared only in cases with very severe cerebral involvement and also in cases with very high parasitaemia alone. these investigations ... | 1975 | 1096306 |
| comparison of diaminodiphenylsulphonepyrimethamine and sulfadoxine-pyrimethamine combinations in the treatment of falciparum malaria in thailand. | | 1975 | 1096374 |
| cerebral malaria in a virulent rodent plasmodial infection. | | 1975 | 1096377 |
| anaemia in mice with concomitant schistosoma mansoni and plasmodium berghei yoelii infection. | 1. the effect on anaemia in mice given plasmodium berghei yoelii 3 and 5 weeks after exposure to schistosoma mansoni cercariae, was investigated. 2. haematological criteria (pcv and haemoglobin levels), reticulocytosis, parasitaemia and splenomegaly were used as indices. 3. anaemia was severe in the animals given p. b. yoelii and in those with mixed infection (p. b: yoelii plus s. mansoni). malaria was found to dominate the picture until the clearance of the parasitaemia. the effect of the inter ... | 1975 | 1096378 |
| the rapid isolation from human blood of concentrated, white-cell-free preparations of plasmodium falciparum. | the sucrose gradient centrifugation method has been applied to representative samples of human (gambian) blood infected with ring, trophozoite, schizont and gametocyte stages of p. falciparum in order to assess quantitatively the efficiency of recovery, white cell removal and the degree of enrichment of the infected cell fraction. maximal white cell removal was 90%. (a.v.) average infected cell recoveries varied with the level of white cell contamination, namely 47% (2-5% wbc), 34% (1-2% wbc) an ... | 1975 | 1096379 |
| counter-current immunoelectrophoresis for the demonstration of malarial antigens and antibodies in the sera of rats and mice. | | 1975 | 1096380 |
| plasmodium berghei: immunologic enhancement of antigen by adjuvant addition. | | 1975 | 1097263 |
| antibody-mediated elimination of malaria parasites (plasmodium berghei) in vivo. | an infective preparation of extracellular blood forms (fp) of plasmodium berghei was used to study some aspects of the interaction between protective antibodies and malaria parasites. fp but not infected erythrocytes (irbc) were shown by the fluorescent antibody technique to be coated by antibodies after in vitro incubation with immune serum. preincubation of both fp and irbc with immune serum followed by their washing did not result in enhanced elimination of the parasites in vivo. however, fp ... | 1975 | 1097338 |
| synthesis of (4-quinolinoamino)aminoalkyltetrahydronaphthalene derivatives for possible antimalarial activity. | (4-quinolinoamino)aminoalkyltetrahydronaphthalene derivatives were synthesized in an attempt to introduce new agents with antimalarial activity. | 1975 | 1097633 |
| potential antimalarials. 9. resolution of alpha-diheptylaminomethyl-6-bromo-9-phenanthrenemethanol by an unusual method. | | 1975 | 1097687 |
| quinoxaline studies. 23. potential antimalarials. substituted 5,8-dimethoxyquinoxalines. | two series of 2,3-disubstituted 5,8-dimethoxy-6-[n- (omega-dimethylaminoalkyl) amino] quinoxalines were prepared: the first series with identical 2,3-substituents h, ch3, c6h5, c6h4-4-cl, and ch2c6h5; and the second with identical styryl groups ch=chc6h5, ch=chc6h4-4-cl, ch=chc6h3-3,4-c12, ch=chc6h4-4-f, ch=chc6h4-4-cf3, and ch=chc6h4-4-no2. none of the substances possessed antimalarial activity; several were toxic at highest dosage levels. | 1975 | 1097693 |
| observations on malaria in indonesian timor. | malaria parasitemias were found in 35% of 520 individuals from a village in timor, indonesia. plasmodium falciparum accounted for 80% of infections. the existence of p. ovale in timor is reported for the first time. the who standard field test for drug resistance did not reveal significant resistance of p. falciparum or p. vivax to chloroquine. | 1975 | 1098490 |
| application of the indirect fluorescent antibody method in a study of malaria endemicity in mato grosso, brazil. | four surveys of malaria endemicity were conducted in the cuiabá sector of mato grosso state, brazil, at 6-month intervals during the period april 1970 to september 1971; during april 1970 a survey was also conducted in the campo grande sector. over 4,000 dual specimens--blood films for parasite diagnosis and filter paper blood spots for determination of fluorescent antibody (ifa) response--were collected from the general population, including school populations whenever possible. parasitologic e ... | 1975 | 1098491 |
| development of antibodies to plasmodium vivax as measured by two different serologic techniques. | sera from individuals infected with plasmodium vivax were tested for the presence of malarial antibodies using the indirect fluorescent antibody (ifa) and the indirect hemagglutination (iga) tests. the primary infection resulted in the conversion of all sera to a positive response in the ifa test, whereas only 50% gave a positive iga response. there was a direct relationship between the duration of the primary parasitemia and percentage giving positive iga response. relapse resulted in high leve ... | 1975 | 1098492 |
| pathogenesis of acute avian malaria. iv. immunologic factors in nephritis of acute plasmodium gallinaceum infections of chickens. | study of urinary waste of chickens with acute plasmodium gallinaceum malaria indicated that serum proteins of the globulin and albumin classes were passed. protein extravasation did not begin until globulin-associated serum antigen and its antibody were detected in the blood. both serum antigen and antibody were found in the wastes for as long as the antigen was present in the blood. extracts of kidney tissues contained serum proteins that were not present in extracts from normal kidneys, and se ... | 1975 | 1098493 |
| natural infections of anopheles albimanus with plasmodium in a small malaria focus. | entomologic surveys conducted in a small village in an area of known high malaria transmission in el salvador yielded a high rate of infection in anopheles albimanus collected inside houses in which cases of malaria had occurred. of 324 specimens dissected, 12 were found to harbor sporozoites or oocysts. this is in contrast to prior reports of extremely low infection rates in collections of this species from malarious areas, and suggests that under some circumstances a. albimanus does meet the c ... | 1975 | 1098498 |
| amodiaquine resistant falciparum malaria in thailand. | amodiaquine cured 38% (13/34) of patients with falciparum malaria in southeast thailand. chloroquine cured 0% (0/13). the cure rates with amodiaquine were the same whether a 1.5 g or 2.0 g course was used. most patients were resistant to amodiaquine at the ri level and to chloroquine at the rii level. in hospital, amodiaquine cleared parasitemia more frequently than did chloroquine. with the 2.0 g course of amodiaquine, the parasite clearance time was 77 hours; the fever clearance time of 36 hou ... | 1975 | 1098499 |