| transmission of plasmodium cynomolgi to aotus trivirgatus monkeys. | | 1975 | 804032 |
| blood protozoa of imported birds. | large numbers of birds, until recently, were brought into the united states each year. countries of origin were varied, and included those of australasia, africa, south america, and the caribbean islands, as well as other places. with them of course come their parasites, some of which may be potential pathogens to domestic avifauna. in part for this reason, a survey was undertaken of blood parasites of birds from pet shops and importers. so far a total of 1234 birds belonging to 186 species has ... | 1975 | 804038 |
| remarks on the status of the genus leucocytozoon sambon, 1908. | authorship of the genus leucocytozoon has been variously assigned to several investigatiors, especially danilewsky and ziemann. recently hsu, campbell & levine (1973) have credited it to berestneff. it is herein submitted that they erred in doing so and in relegating akiba bennett, garnham & fallis, 1965 and saurocytozoon lainson & shaw, 1969 to synonymy with it. an attempt is made to clarify the confusion that has increasingly surrounded the genus leucocytozoon, and it is recommended that th ... | 1975 | 804039 |
| chemotherapy of plasmodium vivax in saimiri and aotus models. | three standard antimalarial compounds were tested against trophozoite or sporozoite induced infections of the panamanian achiote strain of plasmodium vivax in two species of monkeys. in saimiri sciureus (24 subjects) and aotus trivirgatus (11 subjects), parasite clearance from the peripheral blood averaged 3 days after initiating chloroquine therapy (total dose of 25 mg base/kg body weight over 3 days or single dose of 10 mg base/kg. trophozoite induced infections were cured in all of 10 saimiri ... | 1975 | 804263 |
| biological screening in the u.s. army antimalarial drug development program. | the methods of testing drugs in the united states army antimalarial drug development program are described. to date over two hundred thousand compounds have been screened. for each 3,000 compounds evaluated in the primary screen, only 1 is assessed for efficacy in the final test system. of those potential antimalarials assessed in this last system, only about half are deemed worthy of preclinical toxicological evaluation. | 1975 | 804264 |
| pathogenesis of acute avian malaria. ii. anemia mediated by a cold-active autohemagglutinin from the blood of chickens with acute plasmodium gallinaceum infection. | a cold-active hemagglutinin for trypsinized human type "o" erythrocytes (cah) from blood of chickens with acute plasmodium gallinaceum malaria was found to be associated with 19 s and 7 s globulin fractions of malarious chicken blood, but cleavage with 2-mercaptoethanol indicated that it was primarily of the igm class of antibody. in serologic tests cah reacted with trypsinized erythrocytes, and anti-chicken globulin. it did not react with other of the antigens or antibodies detected in the bloo ... | 1975 | 804265 |
| pyruvate kinase in malaria host-parasite interaction. | | 1975 | 805379 |
| fatal infections in protein-calorie malnourished children with thymolymphatic atrophy. | the clinicopathological features of 25 children who died with protein-calorie malnutrition were studied. all but four subjects were found at necropsy to have nutritional thymectomy and all but 3 died of infectious diseases. the infectious agents were chiefly intracellular micro-organisms including miliary tuberculosis, herpes simplex, varicella, measles, pneumocystis carinii, and plasmodium falciparum. staphylococcal infections, salmonellosis, shigellosis, strongyloidiasis, and hookworm were oth ... | 1975 | 805568 |
| letter: malaria vaccines. | | 1975 | 805627 |
| antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria. | this presentation deals with the historical development of the antifolate pyrimidines and related compounds, first as antimalarial substances and later as potent antibacterial agents. it describes the first quantitation of the combined action, through sequential blockade, of the substances with sulfonamides, and outlines the usefulness of the combinations in the therapy of normally sensitive and multiresistant strains of plasmodium falciparum. | 1975 | 805650 |
| hematozoa of the anatidae of the atlantic flyway. ii. tthe maritime provinces of canada. | the prevalence of hematozoa (diagnosed from blood films) in a sample of 4200 anatids representing 14 species collected in new brunswick, nova scotia and prince edward island during the period 1969-1973 is given. thirty percent of the birds harboured hematozoa; the commonest blood parasite was haemoproteus (parahaemoproteus) nettionis (in 18% of the sample), followed by leucocytozoom simondi (in 14% of the sample). four species of plasmodium occurred in 5% of the sample-plasmodium circumflexum wa ... | 1975 | 806712 |
| centrifuge techniques in the preparation of malaria thin blood smears. | | 1975 | 806848 |
| studies on plasmodium gallinaceum and plasmodium juxtanucleare from the malayan jungle fowl gallue gallus spadiceus. | | 1975 | 806969 |
| studies on the structure and invasive behaviour of merozoites of plasmodium knowlesi. | | 1975 | 807001 |
| inducation of antibody against actin from myxomycete plasmodium and its properties. | plasmodium actin was highly purified by gel filtration of crude g-actin on sephadex g-100 followed by ultracentrifugation after polymerization in the presence of 1 m urea and 1 mm atp. purified actin showed a single band in the sodium dodecyl sulfate gel electrophoretic pattern. antibody against this purified actin was induced in rabbits. the antibody obtained was immunologically monospecific for plasmodium actin, judging from the following results. (1) the addition of the antibody to a plasmodi ... | 1975 | 807241 |
| letter: malaria vaccines. | | 1975 | 807288 |
| [blood relapses and modifications of the pre-erythrocytic shizonts of plasmodium yoelii using ethionine]. | injections of dl-ethionine during the preerythrocytic period of plasmodium yoeli in thammomys were followed by: 1. a delayed prepatent period; 2. a relapsing parasitaemia with alternatively positive and negative blood at subinoculation of clean mice; 3. a peculiar morphology of the exoerythrocytic schizonts which remain small with a scanty cytoplasm and very few large nuclei. although the authors consider the origin of the relapses to be the rupture of delayed hepatic schizonts under the influen ... | 1975 | 807419 |
| orally-administered silver sulfadiazine: chemotherapy and toxicology in cf-1 mice; plasmodium berghei (malaria) and pseudomonas aeruginosa. | silver sulfadiazine when administered orally and subcutaneously to cf-1 mice in doses not exceeding 1,050 mg/kg proved to have minimal toxicity. no pathology or abnormal reactions were seen in cf-1 mice after receiving 1,050 mg/kg orally and subcutaneously once a day for 30 days. silver sulfadiazine in doses of 1,050 mg/kg, once a day for 5 days cured mice of plasmodium berghei even after splenectomy. parasitemia was reduced to zero in 1-3 days and antimalarial activity was not inhibited signifi ... | 1975 | 807459 |
| parasitological review. experimental monkey hosts for human plasmodia. | | 1975 | 807483 |
| immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. | with strict adherence to ethical guidelines, a volunteer was immunized against sporozoites of plasmodium falciparum and p. vivax, the antigen consisting of attenuated sporozoites of each species inoculated through bites of mosquitoes x-irradiated at a minimum dosage of 15,000 rads. on one occasion this dosage did not render all p. vivax sporozoites noninfective. species specificity of antigen and antibody was demonstrated, but within each species a wide geographical diversity of strains proved i ... | 1975 | 808142 |
| malaria in studies in vitro. iii: the protein synthesising activity of plasmodium falciparum in vitro after drug treatment in vivo. | aotus trivirgatus monkeys with established infections of plasmodium falciparum were treated orally with either chloroquine or the novel compound 1-amidino-3-(3-chloro-4-cyanophenyl) urea. blood samples were cultured in vitro, 18 hours after treatment, when no morphological abnormalities were apparent. the incorporation of radioactive leucine from the medium by the blood of treated monkeys was compared with that of the undosed control. parasite maturation was also examined. both chloroquine and t ... | 1975 | 808180 |
| five species of panamarian monkeys as new experimental hosts for plasmodium simium. | | 1975 | 809569 |
| vaccination against plasmodium knowlesi malaria. | | 1975 | 809872 |
| studies on human malaria in aotus monkeys. vi. infectivity of plasmodium malariae to different anophelines. | anopheles freeborni, a. balabacensis balabacensis, a. atroparvus, a. stephensi, and a. maculatus mosquitoes were infected by feeding on 12 aotus trivirgatus monkeys infected with a nigerian strain of plasmodium malariae. comparative infectivity studies indicated that the first 2 species were the most heavily infected. | 1975 | 810562 |
| some protozoan parasites of wild birds from the vicinity of onderstepoort. | the protozoan parasites of wild birds from the vicinity of onderstepoort are recorded. new host records for the republic of south africa are: haemoproteus in threskiornis aethiopicus, francolinus swainsonii, columba guinea and streptopelia senegalensis; leucocytozoon in anas erythrorhyncha, netta erythrophthalma, c. guinea and passer domesticus and plasmodium in numida meleagris. | 1975 | 810756 |
| the release of antigens by plasmodium falciparum. | antigens were released in vitro human red cells infected with plasmodium falciparum only when parasites reached a late stage of schizogony (probably at rupture of infected red cells during reinvasion). immune complexes formed if antibody was present. serum from immune aotus monkeys opsonized parasite debris from artificially disrupted infected aotus red cells. | 1975 | 810759 |
| ribonucleic acid synthesis in plasmodium knowlesi maintained both in vivo and in vitro. | rna extracted from purified parasites of plasmodium knowlesi was fractionated using agarose gel electrophoresis. preparations from para sites grown both in vivo and in vitro contained species of rna with sedimentation coefficients of 4-0s, 5-0s, 16-6s, 24-2s, 31-4s, 38-0s and 48-3s. there was less rna present in parasites grown in vitro than the equivalent stage parasites grown in vivo but the proportional amounts of the various species of rna was similar in both cases. it is suggested that the ... | 1975 | 810760 |
| protein synthesis in vitro by cryopreserved plasmodium falciparum. | plasmodium falciparum-parasitized erythrocytes obtained from infected owl monkeys (aotus trivirgatus) and stored in the frozen state retain both the capacity to incorporate 14c isoleucine into protein and to infect animals. the cryopreservation method involves the use of glycerol and the reconstitution of isotonicity after thawing. animals have been infected from material held for up to 273 days and protein synthesis has been demonstrated in vitro for up to 180 days after freezing. the specifici ... | 1975 | 811124 |
| simian plasmodium knowlesi malaria: studies of coagulation and pathology. | uniformly fatal simian malaria was induced in ten rhesus monkeys by injection of plasmodium knowlesi. the results of serial studies of platelet and blood coagulation factor levels suggested the occurrence of intravascular coagulation during the last 48 hours of the disease, concurrent with a marked fall in hematocrit levels. fibrinogen survival was slightly decreased (two animals), but quantitative fibrinogen levels were elevated. pathologic studies revealed only minimal evidence of fibrin depos ... | 1975 | 811125 |
| amino acid analogs. iii: new syntheses of monomethyl- and monophenylglutamic acids. | glutamic acid analogs containing 3- and 4-methyl and 2-, 3-, and 4-phenyl substituents were prepared. the 3- and 4-methyl- and 3- and 4-phenylglutamic acids did not inhibit plasmodium berghei and were nontoxic to the host (mice) at 640 mg/kg. the five analogs in addition to 2-methlglutamic acid were inactive against lactobacillus casei at 1000 mug/ml in a defined medium: against escherichia coli, only 2-methylglutamic acid caused 27% inhibition at 10,000 mug/ml. all six analogs failed to inhibit ... | 1975 | 811786 |
| the ribosomes of the simian malaria, plasmodium knowlesi. i. isolation and characterization. | monomeric ribosomes, isolated from the monkey malaria plasmodium knowlesi by the combined use of low concentrations of triton x-100 and differential centrifugation, sedimented in the 80s range and could be dissociated into 60 and 40s subparticles. the base composition of the rrna was typically protozoan; that is, low in guanine and cytosine residues. | 1975 | 811791 |
| quinazolines as inhibitors of dihydrofolate reductase. 3. analogs of pteroic and isopteroic acids. | a series of 19 quinazoline analogs of pteroic and isopteroic acid was prepared with particular emphasis being placed upon carboxylic acid esters. each compound was evaluated as an inhibitor of the dihydrofolate reductases from rat liver as well as from streptococcus faecium. several of the more potent inhibitors were found to be inactive against l1210 leukemia in mice at low dose levels and were lethal to mice at 100 mg/kg. six compounds were also evaluated for antimalarial activity against plas ... | 1975 | 811798 |
| hemoprotozoa in mourning doves and other small birds of western oklahoma. | blood smears obtained from 370 birds live-trapped in western oklahoma were examined for hemoprotozoa. haemoproteus spp. were found in 189 (90.4%) mourning doves (zenaida macroura), one oriole (icterus galbula), two mockingbirds (mimus polyglottos), and three brown thrashers (toxostoma rufum). plasmodium sp. was present in one brown thrasher. haemoproteus spp. in the mourning dove were identified as h. sacharovi and h. maccallumi, with the latter species predominating. the average parasitemia for ... | 1975 | 811816 |
| invasion of erythrocytes by plasmodium falciparum in vitro. | the erythrocytic stages of plasmodium falciparum from aotus trivirgatus were grown in mill hill medium. significant invasion of erythrocytes was obtained by a subculture technique. this invasion, by parasites grown in aotus erythrocytes, was greater when human erythrocytes were added to the cultures than when parasites were allowed to invade aotus erythrocytes. this difference appeared to be a function of the properties of the erythrocyte and was not serum dependent. | 1975 | 812039 |
| in vitro isolation of plasmodium knowlesi merozoites using polycarbonate sieves. | a culture chamber fitted with a polycarbonate sieve has been used to isolate plasmodium knowlesi merozoites as they are released from schizonts. a 3 mum pore-size sieve allows passage of normal erythrocytes and red cells containing rings and trophozoites and can be used to concentrate schizonts from a mixed cell population. a 2 mum pore-size sieve retains normal and parasitized cells and provides uncontaminated merozoites in high yield (5 x 10(10) merozoites per ml schizonts). merozoite viabilit ... | 1975 | 812040 |
| nuclear organisation in gametocytes of plasmodium and hepatocystis: a cytochemical study. | | 1975 | 812282 |
| development of falciparum malaria in a panamanian subspecies of howler monkey. | | 1975 | 812370 |
| preliminary studies on tripiperaquine (m 1020). | | 1975 | 812675 |
| the search for new antimalarial drugs. | | 1975 | 813015 |
| developments in malaria immunology. report of a who scientific group. | | 1975 | 813400 |
| malaria parasites of lemurs. | | 1975 | 813552 |
| malarial infections in aotus trivirgatus with special reference to renal pathology. ii. p. falciparum and mixed malaria infections. | this paper describe the renal pathology in aotus trivirgatus (owl monkeys) following p. falciparum infections and also when the initial p. falciparum was followed by infection with p. malariae or p. brrasilianum. acute p. falciparum infections were associted with high parasitaemia but relatively mild changes in the glomeruli. this was also the case when a second infection with p. falciparum was given after the first infection had been terminated with chloroquine. four monkeys with multiple infec ... | 1975 | 813757 |
| antibody-induced ultrastructural changes of malarial sporozoites. | immunization with irradiated sporozoites produces a considerable degree protection against rodent, simian, and human malaria. this protection is in part antibody mediated. antibodies neutralize sporozoites (sna), i.e. abolish their infectivity, and cause, in vitro, the formation of a thread-like precipitate on the parasites (csp reaction). the present study was undertaken to characterize the ultrastructural aspects of antibody-sporozoite interaction. | 1976 | 815435 |
| relapse in malaria--an enigma. | | 1976 | 815536 |
| blood parasites of some birds from kenya, tanzania and zaire. | a total of 647 birds of 146 species representing 41 families from localities in kenya, tanzania and zaire were examined for blood parasites. a total of 242 (37.2%) birds harbored either single or multiple infections of haemoproteus (16%), leucocytozoon (14%), plasmodium (5.4%), trypanosoma (1.7%), microfilaria (2.9%) or a variety of babesioids and haemogregarines (4.3%). occurrence of blood parasites was greatest in zaire and least in kenya; the occurrence of the different genera varied markedly ... | 1976 | 815570 |
| evaluating new antimalarial drugs against trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys. | an antimalarial drug testing system is described which utilizes trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys. the schizonticidal activity of standard antimalarial drugs in this system is reported. the system accurately predicted antimalarial activity in man of 8 of 9 compounds selected for clinical trials. | 1976 | 816211 |
| complement alterations in rodent malaria. | in the course of rodent malaria, the ability of mouse serum to release immune complexes from lymphocytes (complex-release, or cra), a complement dependent function, becomes profoundly altered. these alterations occur in parallel with changes in the serum levels of the third complement component (c3). a transitory but significant increase in cra and c3 was noticed during the first 3 days after blood-induced plasmodium berghei infection. this was followed by a progressive decrease in cra, which wa ... | 1976 | 816212 |
| analysis of the phospholipid composition of plasmodium knowlesi and rhesus erythrocyte membranes. | | 1976 | 816224 |
| plasmodium simium:ultrastructure of erythrocytic phase. | | 1976 | 816667 |
| studies on human malaria in aotus monkey. vii. comparative infectivity of two strains of plasmodium vivax to to anopheles freeborni, a. maculatus, and for strains of a. albimanus. | a strain of plasmodium vivax from el salvador was shown to be more infectious to the apastepeque strain of anopheles albimanus from el salvador than was a strain of p. vivax from colombia, s. a. the apastepeque mosquito strain was also more susceptible to the savadoran strain of p. vivax than were 2 other strains of this mosquito from el salvador. a strain of a. albimanus from panama was more susceptible to both of the parasite than were any of the salvadoran strains of a. albimanus. | 1976 | 817008 |
| the effect of human immune igg on the in vitro development of plasmodium falciparum. | plasmodium falciparum parasites infecting aotus trivirgatus erythrocytes were cultured in media (harvard and tc199) augmented with human, foetal calf, or other sera. conditions were established which supported growth of parasites and allowed cyclical multiplication when fresh erythrocytes (from aotus or homo) were added in sub-culture (mean multiplication rate: x3). immunoglobulin g pools, prepared from plasma collected in endemic malarious areas in africa and from unexposed britons, were teste ... | 1976 | 817249 |
| chadwick lecture. cerebral malaria--the quest for suitable experimental models in parasitic diseases of man. | | 1976 | 817426 |
| experimental infection of aotus monkeys with plasmodium falciparum light and electron microscopic changes. | six splenectomized aotus owl monkeys were infected with p. falciparum. the animals were sacrificed when they became moribund and tissues were faken for light and electron microscopic studies. electron microscopy revealed marked structural changes in both the liver and the heart. in the liver there was glycogen depletion, lipid droplet infiltration mitochondrial disorganization with reduction in numbers and alterations of the microvilli in the sinusoidal pole and the bile canaliculi. in the heart ... | 1976 | 817680 |
| effect of vitamin a and undernutrition on the susceptibility of rodents to a malarial parasite plasmodium berghei. | the ability of vitamin a deficient rats to resist infection with p. berghei was investigated. when 10 x 10(6) erythrocytes bearing the parasite/100 g body weight were given to the vitamin a protein energy undernourished rats, parasitemia developed in these animals at a faster pace than the controls. a high number (60% to 95%) of red blood cells (rbc) carrying the parasite were noticeable within 6 to 7 days after infection, at which time most animals in this group died. the pair-fed controls (pro ... | 1976 | 818347 |
| [increased non-specific resistance to induction of malaria by sporozoites of plasmodium berghei yoëlii in mice pretreated with a bacterial phospholipid extract]. | the injection of a bacterial phosphospholipid extract increases resistance of mice subsequently challenged with sporozoïtes of plasmodium berghei yoëlii. the pretreatment consisted of one injection of a suspension containing various amounts of phospholipid extract. it was e-fective when it shortly preceded the sporozoïtes inoculation. this resulted in total protection of a great number of animals against various amounts of sporozoïtes. there was a correlation between the dose of ebp injected and ... | 1975 | 819147 |
| malarial infections in aotus trivirgatus with special reference to liver pathology. | | 1976 | 819657 |
| blood parasites of british birds and notes on their seasonal occurrence at two rural sites in england. | during 1972 and 1973, 309 blood smears were taken from 281 birds caught in yorkshire and in hampshire. a seasonal variation in the prevalence of blood parasites with a peak in may was observed. the percentage of birds infected in different months ranged from 3.8 to 15.9. a number of new host records for avian haemoprotozoa were found and these, together with previously unpublished results, are presented in a table which brings the check-list of known british hosts up to date. details are given o ... | 1976 | 819663 |
| haematozoa of east african birds: i. blood parasites of birds from marsabit, nakuru, ngulia and east rudolf in kenya. | blood smears were obtained from 116 birds of 46 species from four locations in kenya. the parasites observed included species of plasmodium, haemoproteus, leucocytozoon and trypanosoma. t. everetti is recorded for the first time from east africa. | 1976 | 819664 |
| demonstration of exoerythrocytic stages of plasmodium vivax in saimiri sciureus. | | 1975 | 820018 |
| techniques and applications of cell fusion and hybridisation: an introduction. | techniques to produce interspecific hybrid cells, and the means to recognise them and to isolate clones of viable cells are described. some applications are reviewed. | 1976 | 820054 |
| plasmodium knowlesi: morphology and course of infection in rhesus monkeys treated with clindamycin and its n-demethyl-4'-pentyl analog. | | 1976 | 820562 |
| role of the micropore in nutrition of the sporozoa. ultrastructural study of plasmodium cathemerium, eimeria ferrisi, e. stiedai, besnoitia jellisoni, and frenkelia sp. | | 1976 | 821187 |
| spectroscopic evidence for the uneven distribution of adenine and uracil residues in ribosomal ribonucleic acid of drosophila melanogaster and of plasmodium knowlesi and its possible evolutionary significance. | rna was isolated from subribosomal particles of the malaria parasite plasmodium knowlesi. the nucleotide composition (mole fraction) of the principal species was obtained (s-rrna, 0.295a, 0.36u, 0.25g, 0.105c: l-rrna, 0.326a, 0.31u, 0.228g, 0.144c). ribosomal rna was also isolated from drosophila melanogaster. optical properties of these a + u-rich species were measured. in all four cases analysis of the hypochromic effect revealed that adenine and uracil residues tended to form clusters along t ... | 1976 | 821475 |
| [chemotherapy and chemoprophylaxis of malaria (author's transl)]. | chloroquine and amodiaquine are demonstrably still the most reliable drugs for the treatment of malaria, except in the south east asia area, and in parts of south and central america where an altered sensitivity of falciparum plasmodia has been confirmed. the present position of malaria prophylaxis is, unfortunately, anything but satisfactory. but there are already some good preparations which, if correctly used with consideration of all available information, contribute considerably to the prev ... | 1976 | 822313 |
| letter: plasmodium vivax tissue stage in saguinus geoffroyi. | | 1976 | 822543 |
| delayed dermal hypersensitivity in rhesus monkeys (macaca mulatta) immunized against plasmodium knowlesi. | eighteen rhesus monkeys were immunized with a fresh or lyophilized antigen preparation obtained from erythrocytes infected with plasmodium knowlesi. sixteen of these monkeys showed a positive delayed hypersensitivity response when subsequently skin tested with the immunizing antigen. ten of the 16 positive reactors survived a p, knowlesi challenge, the remaining 6 showed several indications of protection. none of the 18 control monkeys gave a positive skin reaction or survived the challenging in ... | 1976 | 822621 |
| ultrastructural study of plasmodium knowlesi antigen used in vaccination of rhesus monkeys. | material from various steps obtained in the french pressure cell technic of preparing antigen from plasmodium knowlesi-infected red cells, was examined by elctron microscopy. a positively charged colloidal iron solution was used to differentiate between membranes of host red cells and parasites. red cell membranes take the stain, wheras parasite membranes do not. this antigen which has been used previously to protect monkeys against p. knowlesi appears to consist almost entirely of membrane-boun ... | 1976 | 823328 |
| [serodiagnosis of malaria (author's transl)]. | homologous and heterologous malaria pathogens were used as antigens for the determination of malaria antibodies by indirect immunofluorescence. homologous antibodies fell in the second half year, after successful treatment, down to the limit of demonstrability. in inhabitants of endemic malarial areas, who lived in the german federal republic, signs of a fall in antibodies could be observed after about 30 months. the predominance of particular malaria pathogens of the country of origin was recog ... | 1976 | 823409 |
| [different types of gametocytes in mammal's haemosporidia. correlations with the morphology of the tissue schizonts. hypothesis on the evolution of the group (author's transl)]. | the haemosporidia of mammals are classified in 3 groups according to the morphology of the gametocytes: 1) group "vivax" with hepatocystis and several species of plasmodium; 2) group "malariae" with nycteria and a second group of plasmodium; 3) group "falciparum" with only plasmodium. in each group there is a correlation between the morphology of the gametocytes and that of the exo-erythrocytic schizonts. through discussing the host-range and comparing the life cycles of haemosporidia in birds, ... | 1976 | 823859 |
| the preparation of malaria haemagglutination antigen. | methods of preparing malaria antigen were compared. in one experiment a ficoll density gradient was used to obtain a purified suspension of plasmodium knowlesi schizonts from which antigen was prepared. evaluation of methods such as freeze-thawing and the use of the french press following saponin lysis of schizonts demonstrated that a single freeze-thaw was the best method for obtaining the most antigen. a second experiment was done comparing the antigen prepared from schizont infected erythrocy ... | 1976 | 823879 |
| plasmodium knowlesi: in vitro biosynthesis of methionine. | | 1976 | 824155 |
| 5-aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials. | 5-(p-anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the plasmodium berghei and monkey prophylactic (plasmodium cynomolgi) tests. a new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. none of these compounds showed significant antimalarial or prophylactic activity. | 1976 | 824437 |
| reduced 8-aminoquinoline analogues as potential antimalarial agents. | the synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-n,n-diethylaminoethyl)-8-(2-n,n-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline, and 2-substit ... | 1976 | 824447 |
| the effect of incubation in vitro on the susceptibility of monkey erythrocytes to invasion by plasmodium knowlesi. | rhesus monkey erythrocytes when incubated in vitro under similar conditions to those used for the cultivation of plasmodium knowlesi-infected erythrocytes in vitro, exhibit an increase both in their osmotic fragility and in the activity of their acetylthiocholinesterase. no effect was observed on the catabolism of glucose through the glycolytic pathway or through the primary dehydrogenases of the pentose phosphate pathway. the atp content of normal monkey erythrocytes was also unchanged during i ... | 1976 | 824605 |
| [hepatocystis of malaysia. iii.--development of hepatocystis brayi in c. nubeculosus and c. variipenis (author's transl)]. | the development of h. brayi was followed mainly in c. variipenis up to the stage of mature oocysts. unlike h. kochi, the oocysts of h. brayi develop at the same site as those of plasmodium between the epithelium and the basal membrane of the stomach. | 1976 | 825010 |
| [unusual infectious diseases in a municipal hospital (author's transl)]. | the most important criteria for differential diagnosis are presented with reference to case histories: falciparum malaria: relapsing fever, hemolytic anemia, hepatosplenomegaly, leucopenia; kala-azar: insidious course with fever, pancytopenia, macrocytic anemia, hepatosplenomegaly, enlargement of lymph nodes; echinococcosis: symptoms of a benign tumor with displacement. diagnosis: by identification of the pathogen in malaria and kala-azar, serologically in all three diseases and also radiologica ... | 1976 | 825760 |
| culture of human malaria parasites plasmodium falciparum. | | 1976 | 825784 |
| blood parasites of taiwan birds. | blood films were examined from 1477 birds of taiwan (193 species, 49 families). haemoproteus kruse was by far the commonest parasite, with leucocytozoon danilewski a not very close second. it is probable that some of the haemoproteus infections represented new species, and 1 occurring in the bamboo partridge (bambusicola thoracica sonorivox gould) seemed characteristic enough to justify recognition as such; the name haemoproteus bambusicolae sp. n. is proposed for this organism. malaria was foun ... | 1976 | 826624 |
| studies with induced malarias in aotus monkeys. | aotus monkeys have been shown to be susceptible to the three most important species of human malaria as well as to simian, ape, and rodent malaria. the parasites natural to man were maintained by serial passages using trophozoite infected blood. it was then possible to transfer the infections to, and among, other new world monkeys which previously were refractory. the parasites retained their viability in the monkey, were infective to mosquitos, and were transmitted between monkeys and back to m ... | 1976 | 828228 |
| the quartan malarial nephrotic syndrome. | a specific relationship between p. malariae and the nephrotic syndrome, originally postulated on epidemiologic evidence, has been substantiated by clinical, pathologic and immunologic observations. it would appear that quartan malaria causes an immune complex nephritis in some individuals that, once established, is sustained by mechanisms not yet fully explained but which may involve an autoimmune process. evidence to support an immunologic pathogenesis of the renal lesions is provided by the pr ... | 1976 | 828446 |
| [effect of warm waters of the konakovskaia hydro-electric power plant on the infectibility of the young of the roach with myxosporidia]. | data are given on the effect of warm waters of the kanakovskaya hydro-electric power station on the infection level of the roach young with myxosporidians. 1641 one-year old specimens of roach were examined. 11 species of myxosporidians are reported from the zone of warm waters influence while in the control gulf beyond the warming zone--only 7 species. within the larval period only two species, chloromyxum legeri and zschokkella costata, were recorded. their developmental cycle was retraced. un ... | 1976 | 828718 |
| lipids of plasmodium lophurae, and of erythrocytes and plasma of normal and p. lophurae-infected pekin ducklings. | a lipid analysis was performed on the avian malaria parasite plasmodium lophurae, freed from duckling erythrocytes by immune hemolysis, and on the erythrocytes and plasmas of normal and p. lophurae-infected ducklings. major lipids of normal erythrocytes were: phosphatidylcholine (40% of total lipids), phosphatidylethanolamine (20%), cholesterol (20%), sphingomyelin (11%), and glycosphingolipids (5%). major fatty acids of erythrocyte total phospholipids (74% of total lipids) were 16:0 (22%), 18:2 ... | 1977 | 845741 |
| synthesis and in vivo antimalarial evaluation of isopropyl [(4-chlorophenyl)amino]iminomethylcarbamimidate. | isopropyl [(4-chlorophenyl)amino]iminomethylcarbamimidate was synthesized as a potential antimalarial agent. biological activity was evaluated against plasmodium lophurae in turkeys. the activity of this compound was compared to its nitrogen isostere, chloroguanide. | 1977 | 845808 |
| [culex pipiens fatigans: labeling of tissues of normal and infected (plasmodium cathemerium) females after feeding on tritiated amino acids (author's transl)]. | normal and infected culex females were fed 11 different amino acids. these substances were labeled with tritium and each was given separately in glucose solution. after the uptake the marker appears first in crop, cardia and midgut. later on the other tissues get labeled more or less. it seems that the labeling follows a characteristic pattern for each amino acid. essential amino acids are taken up intensively; for example leucine not only in the midgut epithelium but also in the ovary and the f ... | 1977 | 848081 |
| plasmodium yoelii: an inbred model for protective immunization against malaria in balb/c mice. | | 1977 | 849768 |
| plasmodium chabaudi: host lymphocyte-macrophage interaction in vitro. | | 1977 | 862706 |
| experimental infection with plasmodium chabaudi in rats. observations on adaptation and the immune responses to infection. | plasmodium chabaudi was adapted to rats after some initial refractoriness. progressive adaptation was indicated by shortening of the prepatent period and increases in peak parasitemia with successive passages. rats infected with parasites of early passages resisted the infection, and even splenectomized rats quickly recovered. however, the parasites appeared to become more virulent with successive passages and after the 45th passage, all adult rats inoculated with the parasite died with severe h ... | 1977 | 864563 |
| [ultrastructural study of multiple mitoses during sporogony of plasmodium b. berghei]. | | 1977 | 864828 |
| inhibition of the immune response to whooping cough and tetanus vaccines by malaria infection, and the effect of pertussis adjuvant. | plasmodium yoelii infection of mice depressed their capacity to build up humoral immune response to diphteria vaccine and protective immunity against tetanus toxin. this immunodepression was overcome by freund's complete adjuvant or killed pertussis bacilli (whooping cough vaccine). these results suggest that vaccines should be given in association in malaria endemic area. | 1977 | 869103 |
| the plasmodium lophurae (avian malaria) ribosome. | ribosomes were isolated from plasmodium lophurae by triton x-100 lysis and ultracentrifugation. plasmodium lophurae ribosomal subparticles, produced by treatment of ribosomes with puromycin, were separated by sucrose gradient centrifugation. the nucleotide base composition of p. lophurae ribosomal rna (rrna) from intact ribosomes and subparticels was low in guanine-cytosine content (approximately 37% g + c) whereas the rrna of the host cell (duck reticulocyte) was considerably higher (64% g + c) ... | 1977 | 881657 |
| cytofluorograf detection of plasmodium yoelii, trypanosoma gambiense, and trypanosoma equiperdum by laser excited fluorescence of stained rodent blood. | samples of rat blood infected with plasmodium yoelii (3% parasitized erythrocytes), trypanosoma gambiense, or trypanosoma equiperdum (greater than 50 trypanosomes per microscope field at 400 x) were fixed with 0.5% glutaraldehyde in phosphate buffered saline, then stained with acridine orange (ao) at 10(-4), 10(-5), or 10(-6) m for 0 to 15 min at 5 c or 25 c and/or ethidium bromide (eb) at 0.05 mg/ml for 20 min at 25 c. stained cells were analyzed with a laser cytofluorograf (bio/physics systems ... | 1977 | 886402 |
| malaria eradication in portugal. | research on malaria, which was endemic in several parts of portugal at the beginning of this century, was intensified in the 1940's and led to the development of better control methods, especially in the rice-growing areas of the country. in the 1950's residual ddt spraying was introduced and followed by extensive detection of cases of malaria and their treatment. plans for eradication of the disease were made, and by 1958 the transmission of the infection was interrupted in nearly all areas of ... | 1977 | 888169 |
| plasmodium gallinaceum: changing virulence patterns of malaria parasites during adaptation from neonate chick to chicken embryos. | | 1977 | 891706 |
| plasmodium gallinaceum: vaccination in chickens. | | 1977 | 891707 |
| [physiological age of anopheles labranchiae atroparvus van thiel in the gdańsk region]. | | 1977 | 899019 |
| [antimalarial 6-aminoquinolines, ix: 2-and 4-hydroxymethyl derivatives (author's transl)]. | | 1977 | 901146 |
| plasmodium ovale malaria in canada following transfusion. | | 1977 | 912619 |
| current concepts in parasitology. malaria. | | 1977 | 917071 |
| [present-day problems of malaria, parasitological recall]. | | 1977 | 918520 |
| survival of aegyptianella pullorum, anaplasma marginale and various parasitic protozoa following prolonged storage in liquid nitrogen. | various protozoa species were examined using in vivo and in vitro methods to determine their ability to survive prolonged periods of storage in liquid nitrogen. the following protozoan species were successfully recovered after they had been cryopreserved for a period over 10 years: trypanosoma lewisi, t. cruzi, t. congolense, t. brucei, t. rhodesiense, t. gambiense, t. evansi, t. equinum, t. equiperdum, leishmania donovani, plasmodium berghei, p. praecox (relictum), babesia rodhaini and b. canis ... | 1977 | 919686 |