| plasmodium (giovannolaia) pedioecetii from the lesser prairie chicken, tympanuchus pallidicinctus. | | 1978 | 739305 |
| [the question of anhaptoglobinemia in immigrants from west africa (author's transl)]. | studying the plasmatic level and the phenotype of haptoglobine (hp) in 71 west africans living in france, the authors did not record any case of absence of hp (hpo) and did not see any significant correlation between the hp and the duration of stay in france. they conclude that plasmodium falciparum likely does not play any role in the origin of the hpo peculiarity in west african immigrants. | 1978 | 745527 |
| chemotaxis and movement of physarum polycephalum and its responses to some neurotransmitters and psychomimetic compounds. | a method was developed for studying the effect of some neurotransmitters and drugs on the rate of movement and the chemotactic value of the plasmodium of physarum polycephalum. epinephrine (adrenaline) at a concentration of 1 mg/ml, reduced the rate of movement and shortened the length of the cycles of shuttle streaming, but did not affect the chemotactic response. the drugs dl-amphetamine, cannabinol and heroin diminished the rate of movement, whereas na-barbitol misled the chemotactic response ... | 1977 | 753899 |
| plasmodium malaria infection in a 4 month old infant. | | 1978 | 757838 |
| the treatment of malaria. | at least four doses of quinine followed by a single dose of mefloquine or by a single dose of sulfadoxine-pyrimethamine are two highly effective regimens for chloroquine-resistant falciparum malaria. mefloquine alone is valuable in ambulant patients. chloroquine-sensitive falciparum malaria can be treated with a course of chloroquine. vivax and all other types of malaria should be treated with sequential chloroquine and primaquine. quinine, by intravenous infusion, is the most effective drug for ... | 1976 | 764937 |
| receptivity to malaria in europe. | experimental work has confirmed the refractoriness of anopheles atroparvus to tropical strains of plasmodium falciparum to which a. labranchiae may also be refractory. this indicates a lower receptivity to malaria in europe than the existing vector densities and increasing number of parasite carriers would suggest. | 1975 | 764992 |
| a strain of plasmodium vivax characterized by prolonged incubation: morphological and biological characteristics. | numerous strains of p. vivax, distinguishable chiefly by their biological characteristics, are known to exist. two main varieties are recognized: the so-called temperate and tropical strains. the most extreme example of the former-designated by nikolaev as p. vivax hibernans-constantly exhibited an extremely long incubation period. the strain is no longer in existence and no type material has been preserved. in its place, a north korean strain with a generally long incubation period has been stu ... | 1975 | 764993 |
| thick-smear plasmodium falciparum antigen from in vitro cultures for the indirect fluorescent antibody test. | an important prerequisite for serological studies is the availability of specific antigens with which a high, consistently reproducible degree of test sensitivity can be obtained. in the present study, thick films of p. falciparum antigen were made from in vitro cultures in order to evaluate this antigen in terms of the sensitivity and reproducibility of the indirect fluorescent antibody test, as compared with an antigen prepared from washed infected erythrocytes of aotus trivirgatus monkeys. th ... | 1975 | 764994 |
| dynamics of thymidine incorporation by spleen cells from rats infected with plasmodium berghei. | the in vitro incorporation of thymidine by spleen cells of rat infected with plasmodium berghei was higher than that of normal rat spleen cells. the incorporation was proportional to the number of cells in the system and was related to the day of infection, e.g. spleen cells from malarious rats incorporated up to forty times as much thymidine as did normal spleen cells 21 days after inoculation. at the same time, the response of the malarious spleen cells to phytohaemagglutinin (pha) was only on ... | 1975 | 765025 |
| observations on the recent incidence of malaria. | | 1975 | 765403 |
| synthesis of 5-substituted aminomethyluracils via the mannich reaction. | an extension of the mannich reaction, in which aminomethylation of the five position of uracil, is reported. thus, primary and secondary alkylamines and primary aromatic amines containing ring-activating groups led to the title compounds 3-10. compound 11 in which the aromatic ring contains the ring-deactivating nitro group was synthesized in an alternative way. all compounds were characterized by their elemental and spectral properties. | 1976 | 765460 |
| protection of mice against babesia and plasmodium with bcg. | | 1976 | 765838 |
| [perinatal transmission of plasmodium falciparum malaria]. | two weeks after leaving nigeria for temperate zones and a few hours after giving birth to twins, a nigerian mother suffered an acute attack of malaria due to plasmodium falciparum accompanied by cerebral, renal and hematolgical complications. both infants were apparently healthy at birth, and no parasites were found on peripheral blood smears. both placentas were macroscopically normal. at two months of age the second infant, a boy, developed non-febrile hemolytic anemia due to plasmodium falci ... | 1975 | 766166 |
| the distribution of enzyme variation in populations of plasmodium falciparum in africa. | isolates of plasmodium falciparum collected from the east and west coasts of tropical africa and also from several inland regions have been examined for electrophoretic forms of the enzymes gpi, ldh and 6pgd. variation within and between isolates was found in the parasite forms of all three enzymes. while not disproving the existence of genetic divisions between p. falciparum populations in africa the distribution of this variation provides no evidence for such a hypothesis. | 1975 | 766317 |
| proceedings: changes in pha and lps responsiveness in murine malaria. | | 1975 | 766318 |
| proceedings: the passive transfer of immunity to plasmodium berghei yoelii. | | 1975 | 766319 |
| proceedings: the t-cell response in murine malaria. | | 1975 | 766320 |
| proceedings: pharmacology of plasmodium berghei. | | 1975 | 766321 |
| proceedings: invasion of human red cells by plasmodium falciparum in vitro. | | 1975 | 766322 |
| the plasmodium berghei-infection in isogenic f1 (c57bl x dba)-mice. i. the course of the infection and immunization experiments. | the malarial infection caused by plasmodium berghei (strain k 173) was observed in the isogenic mouse strains c3h, c57bl, dba, and the f1 (c57bl x dba)-hybrids. in addition immunization experiments were carried out by intermittent suppression of the parasite multiplication through maintaining the infected animals on a milk diet for various length of time. the f1-hybrids were the most resistant mice and immunization was most effective in these animals, too. but if the course of the infection was ... | 1975 | 766337 |
| malaria: macrophage migration inhibition factor (mif). | | 1976 | 768434 |
| malaria: decreased survival of transfused normal erythrocytes in infected rats. | | 1976 | 768435 |
| antimalarials. 8. synthesis of amino ethers as candidate antimalarials. | based upon the antimalarial activities demonstrated by compounds i and ii a series of amino ethers represented by structures iii-vi was synthesized. these structures incorporated several modifications of compound ii. the compounds prepared displayed no activity in either the rane p. berghei mouse screen or the rane p. gallinaceum sporozoite-induced chick test. | 1976 | 768473 |
| antimalarials. 11. 2-vinylogs of substituted 2-aryl-4-quinoline amino alcohols. | 3-(p-chlorobenzylidene)-5, 7-dimethyl-2, 3-dihydro-1h-cyclopenta[b]quinoline-9-(di-n-butylaminomethyl)methanol and 2-[beta-(p-chlorostyryl)]-6, 8-dimethylquinoline-4-(di-n-butylaminomethyl)methanol were synthesized from 6, -8-dimethyl-4-hydroxycarbostyril by 3, 3-dichlorination, dimethoxylation th the 3-ketal, basic hydrolysis to the glyoxal acetal, pfitzinger condensation with cylopentanone or acetone to the 2, 3-trimethylene or 2-methylquinoline, condensation with p-clphcho at the 2-methylene ... | 1976 | 768474 |
| coagulation studies in falciparum and vivax malaria. | coagulation factors and serum fibrin degradation products (fdp) were studied in 31 cases of acute falciparum malaria with severe complications, 13 cases without severe complications, and 6 cases of vivax malaria. seven of 13 cases of acute falciparum infection with severe complications died and the coagulation studies were markedly changed and there were high levels of serum fdp. the degree of changes in coagulation and serum fdp varied with the severity of the symptoms and signs and there were ... | 1975 | 769173 |
| the plasmodium berghei-infection in isogenic f1(c57b1 x dba)-mice. ii. antibodies and antigens in the serum. | using the fluorescent antibody technique it was possible to demonstrate antibodies in the sera of f1(c57b1 x dba)-mice already during the first week of infection with plasmodium berghei, strain k 173. these antibodies reached high titers during the second and third week, but, nevertheless, the animals died from the infection. coincidently with the fat-antibodies plasmodial antigens could be found in the sera of infected mice. the numbers of these antigens increased in the course of the infection ... | 1976 | 769269 |
| plasmodium berghei: characteristics of a selected population of small free blood stage parasites. | the characteristics of a selected population of small blood stage parasites obtained by differential centrifugation of a population of p. berghei parasites freed by continuous flow sonication are described. about 10% of these free parasites are merozoites, many others are transitional forms having some merozoite characteristics. the parasite preparations are infectious and sufficiently resistant to incubation at 37 degrees c to be useful experimentally. disc gel electrophoresis analysis indicate ... | 1976 | 769270 |
| transfusion malaria as a consequence of the 1974 war between turkey and greece--two cases. | two cases of transfusion induced plasmodium malariae malaria that occurred in august and september 1974 in new york city were direct results of the outbreak of war between turkey and greece on the island of cyprus in july 1974. the cases could be traced to two greek immigrants with latent infection (one being the longest ever recorded) who independently donated blood after solicitation for people in need living in the country of their ancestors. in view of current rules for donor acceptability, ... | 1976 | 769569 |
| chloroquine sensitivity of plasmodium falciparum in ethiopia. ii. results of an in vitro test. | field trials were performed in two areas of ethiopia with the rieckmann in vitro test for chloroquine sensitivity of plasmodium falciparum. blood cultures from 82 test subjects showed growth of trophozoites to the schizont stage in control vials. growth in test vials occurred in 21 cultures incubated with chloroquine at concentrations of 0.5 nanomoles or more per ml of blood. in vitro results confirm previous results obtained with an in vivo test. | 1976 | 769570 |
| febrile illnesses resulting in hospital admission: a bacteriological and serological study in jakarta, indonesia. | a study of 741 indonesian patients with fever was carried out in order to determine what serious febrile illnesses are prevalent in jakarta. all patients were hospitalized primarily because of fever and were studied by bacteriological and serological methods. bacteremia due to salmonella typhi (150 cases), s. enteritidis (36 cases), or both (2 cases) was common in both children and adults. one s. enteritidis isolate was chloramphenicol resistant. serological evidence of salmonella infection was ... | 1976 | 769571 |
| single-dose therapy of falciparum malaria using pyrimethamine in combination with diformyldapsone or sulfadoxine. | patients with naturally acquired chloroquine-resistant falciparum malaria were studied in thailand. the fixed combination of pyrimethamine 75 mg and sulfadoxine 1,500 mg (adult dose) cured 85% of patients with an average pretreatment parasite count of 60,000 per mm(3). the fixed combination of pyrimethamine 50 mg and 800 mg diformyldapsone (dfd) cured 43% of patients with an average pretreatment parasite count of only 17,000 per mm(3). the difference in cure rates was statistically significant ( ... | 1976 | 769572 |
| the seroepidemiology of malaria in middle america. iii. serologic assessment of localized plasmodium falciparum epidemics. | epidemiologic studies were done in two localities, one in panama and one in el salvador, where outbreaks of plasmodium falciparum malaria occurred. the indirect fluorescent antibody (ifa) method was helpful in defining the intensity of the outbreaks, the species of parasite involved, and, through parallel surveys of adjacent localities, the localized character of outbreaks. in escobal, panama 71 (34%) of 211 persons examined were ifa-positive for p. falciparum, although only 1 positive blood fil ... | 1976 | 769573 |
| chloroquine sensitivity of plasmodium falciparum in ethiopia. i. results of an in vivo test. | the in vivo response of plasmodium falciparum to the who single test dose (10 mg/kg body weight) of chloroquine base was examined in ethiopia at four localities where malaria was meso- or hyperendemic. parasitemias cleared by the 3rd day after chloroquine administration in all of the 150 test subjects. no recrudescences were detected during the 6-day or 11-day follow-up periods. the value of the in vivo test was severely limited by the inability to quarantine subjects and follow them for the 28- ... | 1976 | 769574 |
| malarial antibodies measured by the indirect hemagglutination test in west african children. | the indirect hemagglutination test with plasmodium falciparum antigen was used to measure malarial antibodies in filter paper blood specimens from 527 west african children. a slight decline in antibodies was noted in 6- to 8-month-old children wh o had no malaria parasites in their blood smears. children older than 10 months had similar antibody levels regardless of the presence or absence of demonstrated parasites in blood smears. | 1976 | 769576 |
| a temporal relationship between reticuloendothelial system phagocytic alterations and antibody responses in mice infected with plasmodium berghei (nyu-2 strain). | malaria-induced immunosuppression has been demonstrated in humans and experimental animals. the suppressed immune response has been suggested to be primarily humoral and not cellular in nature, since classical lymphocytic cell-mediated responses have been reported to be normal. since previous results have demonstrated that an impairment in macrophage antigen processing may be a contributing factor in malaria-induced immunosuppression, the present studies were conducted to determine if the macrop ... | 1976 | 769577 |
| suppressive activity of mefloquine in sporozoite-induced human malaria. | mefloquine hydrochloride [wr 142,490; alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride] was tested for suppressive effect on sporozoite-induced malaria in nonimmune volunteers living in an area where malaria is not naturally transmitted. single doses of 250 mg were given at weekly intervals, 500 mg at intervals of 2 weeks and 1,000 mg at intervals of 4 weeks, to men bitten by 10 to 15 mosquitoes heavily infected with a chloroquine- and pyrimethamine-resistant strain ... | 1976 | 769678 |
| editorial: transfusion malaria in developing countries. | | 1976 | 769889 |
| jaundice and hepatomegaly in malaria. | | 1975 | 770013 |
| response of p. falciparum infection to chloroquine therapy in some parts of tamil nadu and karnataka states. | | 1975 | 770318 |
| treatment of p. falciparum with chloroquine and primaquine in dharmapuri district, tamil nadu. | | 1975 | 770319 |
| adoptive transfer of immunity to plasmodium berghei by a population of immune rat spleen cells resistant to cyclophosphamide. | | 1976 | 770355 |
| the prevalence of babesia antibodies in nigerians. | | 1976 | 770357 |
| nonspecific resistance to infection induced in mice by a water-soluble adjuvant derived from mycobacterium smegmatis. | the effect of a nontoxic, water-soluble adjuvant (neo-wsa) from delipidated cells of mycobacterium smegmatis on the susceptibility of mice to infection with four challenge organisms was studied. an intravenous dose of 1 mg of neo-wsa per mouse 24 hr before challenge enhanced resistance to infection with a fungus (candida albicans), a gram-negative bacterium (klebsiella pneumoniae), and a gram-positive bacterium (streptococcus pneumoniae). protection by neo-wsa was not significant when the mice w ... | 1976 | 772130 |
| sero-epidemiological surveillance of disappearing malaria in greece. | | 1975 | 772232 |
| chloroquine-resistant falciparum malaria in east kalimantan, indonesia. | following the discovery of four imported chloroquine-resistant p. falciparum infections in the province of yogyakarta (island of java) sensitivity tests were carried out in the province of east kalimantan island of borneo). twenty subjects were given 25 mg. of chloroquine base per kilogram of body weight over three days. two infections were found resistant at the rii level and a third at the ri level with early recrudescence on day 7. in the other 17 cases followed up to day 21, six were found a ... | 1976 | 772235 |
| [letter: a recent case of human babesiasis]. | | 1976 | 772600 |
| histamine changes in plasmodium falciparum malaria. | histamine, serum complement factor 3 (c'3) and platelets were studied in 33 plasmodium falciparum patients. elevation of histamine level in the blood was found during acute infection but was more marked in the group of patients with systemic complications. a correlation between histamine changes, clinical complications, reduction of c'3 and degree of thrombocytopenia was observed. the possible role of histamine in the development of complications in p. falciparum infection and the possible relea ... | 1976 | 772896 |
| a new look at the protection of hemoglobin as and ac genotypes against plasmodium falciparum infection: a census tract approach. | a total of 4,097 randomly selected children under 5 years in accra, ghana were investigated for hb type, malarial parasite species, and parasite density. even though malarial infection rates in this metropolitan population were lower as compared to holoendemic areas, the differential survival of hb s carriers was confirmed. in addition, similar but less pronounced survival effects were seen in hb c heterozygotes. hb s carriers had the highest infection rates. more females than males were infecte ... | 1976 | 773175 |
| drug resistance in the human malarias. | | 1975 | 773274 |
| glucose-6-phosphate and 6-phosphogluconate dehydrogenase activities human erythrocytes infected with plasmodium falciparum. | | 1976 | 773316 |
| editorial: new look at malaria. | | 1976 | 773496 |
| quinine disposition during malaria and during induced fever. | quinine disposition was studied in 5 subjects before and during an experimentally induced infection with a chloroquine-resistant strain of plasmodium falciparum and in 2 individuals before and during artificially induced fever. plasma quinine levels were determined by both a benzene extraction method (qb), which measures principally unmetabolized quinine, and a metaphosphoric acid precipitation method (qmpa), which measures quinine and quinine metabolites. the ratio qb/qmpa in plasma was used to ... | 1976 | 773582 |
| plasmodium berghei berghei: irradiated sporozoites of the anka strain as immunizing antigens in mice. | | 1976 | 773654 |
| plasmodium berghei: i. immunochemical properties of fractions of a soluble extract. | | 1976 | 773655 |
| plasmodium berghei: ii. immunobiological properties of fractions of a soluble extract. | | 1976 | 773656 |
| an in vitro assay for t cell immunity to malaria in mice. | after infection with a nonlethal strain of murine malaria (17xnl plasmodium berghei yoelli), balb/c mice are then resistant to a lethal strain (17xl p.b. yoelli). balb/c mice were infected with 17xnl, anc challenged 3 weeks later, after clearing their parasitemias, with 17xl. three weeks thereafter, spleen cells from such immune animals were used to define an early peaking t-dependent (anti-theta sensitive) antigen-specific proliferative response when incubated in vitro with 17xl infected rbc, o ... | 1976 | 774978 |
| antimalarials v: aminobenzothiazoles. | four mono- and dialkylated 4-aminobenzothiazoles (vii-x) were prepared as analogs of potent causal prophylactic drugs in the 8-aminoquinoline series. compounds vii and viii were toxic at 80 mg/kg in the chick; ix was inactive at 640 mg/kg. in a sporozoite-induced mouse test system, x was inactive at 30 mg/kg and toxic at 480 mg/kg. none of the compounds was active as a suppressive drug. | 1976 | 775054 |
| antimalarial activity of some novel derivatives of 2,4-diamino-5(p-chlorophenyl)-6-ethylpyrimidine (pyrimethamine). | thirteen new analogs of 2,4-diamino-5(p-chlorophenyl)-6-ethylpyrimidine (daraprim, pyrimethamine) in which the alph position of the 6-ethyl substituent was modified were prepared. the respective oxygens analogs (ketals, ketone, alcohol), the dimethyl hydrazone, and the nitrone displayed activities in the range of 1/4 to 1/16 that of pyrimethamine toward plasmodium berghei in mice. the therapeutic ratios of some of these compounds may be slightly better than that of pyrimethamine. | 1976 | 775088 |
| chloroquine-resistant falciparum malaria from irian jaya (indonesian new guinea). | a strain of plasmodium falciparum, transmitted in irian jaya (indonesian new guinea) was isolated in 1974 and sent to the university of maryland for characterization in nonimmune volunteers. at maryland the indonesia (whit.) strain, as it has been designated, was transmitted to colonized anopheles stephensi. prophylactically, it was not suppressed by proguanil hydrochloride 100 mg. daily. curatively, parasitaemia was not cleared by treatment with 1-5 g. (base) in three days of chloroquine or amo ... | 1976 | 775119 |
| [malaria prophylaxis]. | | 1976 | 775347 |
| increased frequency of chloroquine resistant p. falciparum on a rubber estate in peninsular malaysia during two years of systematic chloroquine treatment. | chloroquine pressure was applied over a 22 month period on a somewhat isolated, malarious rubber estate by examination of residents at 4-week intervals and treatment of parasitaemias with chloroquine. during this time the monthly attack rate for p. falciparum rose four-fold to an average of nearly 18% per month, while that of p. vivax remained relatively constant at about 8%. eight in vivo chloroquine resistance studies, which allowed both detection of late recrudescing r-i resistance and estima ... | 1975 | 775652 |
| proceedings: the chemotherapeutic action of pam-780 against plasmodium berghei malaria in mice. | | 1975 | 775791 |
| spleen reactivity in experimental malaria of rodents. | | 1975 | 776124 |
| editorial: renal lesions in human malaria. | | 1976 | 776349 |
| malaria guidelines: cdc recommended treatment schedules, 1974. | | 1976 | 776514 |
| vivax cerebral malaria in jammu. | | 1976 | 776824 |
| letter: transfusion malaria and immigrant blood donors. | | 1976 | 778305 |
| viruslike particles in malaria parasites. | the ultrastructural appearance of viruslike particles in several malaria parasites at different times in sporogony is described in detail. emphasis is placed on particle size, 42 to 52 nm, density and the presence or absence of geometric configuration of particle aggregations in p. berghei ookinetes, and p. gallinaceum early oocysts. this particle appearance is compared with that noted in later oocysts of p. berghei, p. gallinaceum, and p. c. bastianelli and with negatively-stained particles obt ... | 1976 | 778372 |
| new synthesis of substituted pyrrolo[1,2-alpha][1,3]diazepine and its pharmacological activity. | a facile route for the synthesis of the substituted pyrrolo[1,2-alpha][1,3]diazepine nucleus from readily available starting material is reported. the compound was tested for antimalarial activity in mice, antineoplastic activity in mice, acute hypotensive activity in rats and dogs, effect on cholesterol-lipoprotein levels in rats, anti-inflammatory activity in rats, antiviral activity in mice, cns depressant or stimulant activity in mice, diuretic activity in fasted rats, and antidiabetic activ ... | 1976 | 778377 |
| synthesis and antimalarial activity of dibenz[c, e]azepine derivatives. | a series of 6-alkyl-2,10-bis(trifluoromethyl)-5h-dibenz-[c,e]azepines were synthesized via a condensation reaction between 5,5'-bis(trifluoromethyl)-2,2'-diformylbiphenyl and the appropriate amine. these compounds were screened for antimalarial activity and were found to be inactive. | 1976 | 778378 |
| the resistance factor to plasmodium vivax in blacks. the duffy-blood-group genotype, fyfy. | duffy-blood-group-negative human erythrocytes, fyfy, are resistant to invasion in vitro by plasmodium knowlesi. the fyfy genotype is found predominantly in african and american blacks, who are the only groups completely resistant to infection by p. vivax. to determine if the fyfy genotype is the vivax resistance factor, we performed blood typing on 11 black and six white volunteers who had been exposed to the bites of p. vivax-infected mosquitoes. only the five fyfy blacks were resistant to eryt ... | 1976 | 778616 |
| editorial: a new frontier for infectious disease research? | | 1976 | 778619 |
| [letter: transplacental passage of soluble plasmodial antigens. induction of a specific immune tolerance?]. | | 1976 | 778794 |
| [malarial encephalopathy and disseminated intravascular coagulation (author's transl)]. | clinical and anatomical studies of a case of malarial encephalopathy are described in a 51 year old man. in view of the typical symptomatology it was important to ascertain an period even brief of stay in an endemic area. only when this was confirmed the appropriate investigations could be planned (in thic case thick blood drop test) to identify the parassite. the physiopathological mechanisms through which the malarial infection causes the parenchymal lesions are considered. such lesions accord ... | 1975 | 778999 |
| persistence and recurrence of s-antigen in plasmodium falciparum infections in man. | the persistence of heat stable malarial antigens (s-antigens) in the sera of gambian children following treatment for severe plasmodium falciparum infections was investigated. in most cases s-antigens ceased to be demonstrable within 7 days but in some they were detected for several weeks and their persistence correlated with both the density of parasitaemia and the antigen titre observed before treatment. an exponential loss of circulating antigen was, in the majority of individuals, accelerate ... | 1975 | 779155 |
| chronic malarial infection in balb/c mice. effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen. | chronic malarial infection was established in balb/c mice by following plasmodium berghei yoelii with p.b. berghei infection. it was found that the igg plaque-forming cell response to sheep erythrocytes was depressed for at least six months. a preliminary investigation of the histological changes in the spleen and liver is described. the possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed. | 1975 | 779156 |
| letter: response of ethiopian strains of plasmodium falciparum to amodiaquine. | | 1975 | 779158 |
| development of different strains of plasmodium vivax in two species of anopheles. | anopheles freeborni mosquitoes with oocyst infections had salivary gland infections at a higher rate of plasmodium vivax from the new world than with strains from asia, particularly those from south vietnam. anopheles maculatus mosquitoes supported development from oocysts to heavily infected salivary glands for all the strains of p. vivax tested. the results suggest that p. vivax introduced from vietnam would be less likely to be transmitted by native a. freeborni mosiquitoes than would malaria ... | 1976 | 779500 |
| cross reactivity between anaplasma marginale and two plasmodium species as demonstrated by passive hemagglutination. | two types of antigens were prepared from each of 3 partially purified preparations of anaplasma marginale, plasmodium lophurae, and p berghei. hemagglutination tests were conducted with homologous serums to detect antigenic relationships between these organisms. serums were also absorbed with both homologous and heterologous antigen preparations. cross reactivity between these organisms was observed. | 1976 | 779540 |
| complement and malaria. | | 1976 | 779685 |
| a comparison of methods used for the removal of white cells from malaria-infected blood. | | 1976 | 779686 |
| [50 cases of acute malaria: symptomatic study, especially cardiac]. | the authors have studied 50 records of patients who had presented an acute attack of p. falciparum malaria. both sexes were equally implied. young people were predominant. the distribution of cases was about the same in the whole year. the fever decreases on the second day and increases on the third day (300/0). among the classical signs: relative rarity of hepatomegalia (100/0), splenomegalia (10 0/0), jaundice (140/0), nervous symptoms (100/0). vomiting is rather frequent (30 0/0). from the ca ... | 1975 | 779991 |
| [evaluation of plasmodium falciparum antigen of human origin using indirect immunofluorescence reaction in malaria]. | the authors point out the use of p. falciparum antigens from man in the malaria ifa test. in malaria areas it is very easy to find them and although they are "coated" by antibodies they are quite valuable in significant titers. the use of p. falciparum from man is therefore very interesting for malaria diagnosis in non endemic areas and very useful for malaria surveys in endemic areas. | 1975 | 779993 |
| a focus of hyperendemic plasmodium malariae-p. vivax with no p. falciparum in a primitive population in the peruvian amazon jungle. | findings in a sample population in southeastern peru with a very high rate of malaria infection, due to plasmodium malariae and p. vivax with apparently no p. falciparum, are described. the proportion of persons with p. malariae in this sample population, as determined by slide examination, appears to be the greatest ever reported for any area before the introduction of control measures. although very few p. vivax were found on stained slides, results of the indirect immunofluorescence test indi ... | 1975 | 779996 |
| peripheral lymphocyte subpopulations in human falciparum malaria. | the concentration of circulating t, b, and 'null' lymphocytes was determined in thirty children and three adults with plasmodium falciparum infections in west africa. during infection, both percentage as well as concentration of t cells were decreased as compared to levels following treatment. the percentage but not concentration of b cells was increased. both percentage and concentration of 'null' cells were increased in malaria. patients with splenomegaly had the most severe alterations in t-c ... | 1976 | 780013 |
| the reactivity of spleen cells from malarious rats to non-specific mitogens. | the reaction of spleen cells from rats infected with plasmodium berghei to non-specific mitogens has been measured. the cells have been stimulated in vitro by phytohaemagglutinin, concanavalin-a and by bacterial lypopolysaccharide. in addition the release of lymphocyte activating factor (laf) by splenic macrophages has been assayed using a heterologous thymocyte culture. the reactivity of spleen lymphocytes from malarious rats is severly affected. the cells do not react either to the t cell-spec ... | 1976 | 780016 |
| plasmodium berghei: adaptation of a mouse-adapted strain to the mongolian jird (meriones unguiculatus); infectivity and immunogenicity. | | 1976 | 780117 |
| plasmodium berghei: development of resistance to clindamycin and minocycline in mice. | | 1976 | 780118 |
| plasmodium berghei: phase contrast and electron microscopical evidence that certain antimalarials can both inhibit and reverse pigment clumping caused by chloroquine. | | 1976 | 780119 |
| plasmodium berghei: combining folic acid antagonists for potentiation against malaria infections in mice. | | 1976 | 780121 |
| t and b cell population changes in young and in adult rats infected with plasmodium berghei. | malaria infection in young rats is characterized by high parasitemia, severe anemia, and death. parasitemia is lower in older rats, and the rats usually survive. this study was designed to investigate the immunological basis of this difference. t cell numbers in the thymuses and spleens of young (4 weeks old) and in adult (18 weeks old) infected and control rats were determined by killing with anti-theta serum and complement. the number of complement receptor lymphocytes (b cells) in spleens was ... | 1976 | 780272 |
| adoptive transfer of immunity to plasmodium berghei with immune t and b lymphocytes. | immunity to malarial infection may be transferred with immune lymphocytes. this study was designed to determine which lymphocyte type is responsible for the adoptive transfer of immunity to malarial infection. in one set of experiments, the ability of immune t and b lymphocytes, separated by passage through nylon-wool columns, to transfer immunity to infection was determined. in another experiment, the effect of killing t lymphocytes with anti-theta serum on the transfer of immunity was determin ... | 1976 | 780273 |
| antimalarials. 3. 1,2,4-triazines. | the syntheses of a number of substituted 1,2,4-triazines as potential antimalarials are described. the structural requirements for antimalarial activity are discussed with reference to the substituents of a phenyl group in the 6 position and amino groups at the 3 and 5 positions. of the compounds tested, 2,5, and 7 produced cures in mice infected with plasmodium berghei. compounds 2(3,5-diamino-6-(4-trifluoromethylphenyl)-1,2,4-triazine),3,5,8,12,and 37 produced cures in chicks infected with pla ... | 1976 | 781244 |
| synthesis, antimalarial activity, and phototoxicity of some benzo(h)quinoline-4-methanols. | nine alpha-dibutylaminomethylbenzo[h]quinoline-4-methanols were synthesized from the corresponding 1-amino-naphthalenes by the following sequence: 1-aminonaphthalene leads to 1h-benz[g]indole-2,3-dione leads to benzo[h]quinoline-4-carboxylic acid leads to acid chloride leads to bromomethyl ketone leads to epoxide leads to benzo[h]quinoline-4-methanol. several acid chlorides substituted in the 3 position reacted incompletely with ethereal diazomethane but were efficiently converted, without isola ... | 1976 | 781245 |
| antimalarials. 9. methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols. | nine di- and trisubstituted 9-phenanthrenemethanols bearing methylthio and methylfulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against plasmodium berghei in mice. six of the nine compounds were curative at or below 160 mg/kg. the most active structures contained a methylthio substituent in combination with two chlorine atoms. | 1976 | 781249 |
| malaria eradication and control from a global standpoint. | | 1976 | 781250 |
| human malaria parasites in continuous culture. | plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees c in rpmi 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen (1 or 5 percent). the original parasite material, derived from an infected aotus trivirgatus monkey, was diluted more than 100 million times by the addition of human erythrocytes at 3- or 4-day intervals. the parasites continued to reproduce in their normal asexual cycle of approxima ... | 1976 | 781840 |
| the plasmodium berghei-infection in isogenic f1 (c57b1 x dba)- mice. iii. neonatal thymectomy and cell transfer experiments. | in neonatally thymectomized f1(c57bl x dba)-mice the course of an infection with plasmodium berghei, strain k 173, was unaltered if compared with the course in normal animals. no shortening of the survival time was observed. cell transfer experiments were carried out. in numerous trials it was not possible to convey the protective immunity of immune animals to non-immune animals by the transfer of lymphoid cells. if an acquired immunity was destroyed by heavy x-irradiation it could be restored b ... | 1976 | 781956 |
| malaria - the mime. recent lessons from a group of civilian travellers. | clinical data on 24 civilian patients hospitalized for malaria in the new york hospital were analyzed. of 16 patients infected with plasmodium falciparum, 14 acquired the disease in west africa. only three of the 24 had taken recommended courses of prophylaxis. diagnosis was invariably, and often dangerously, delayed because physicians often made diagnoses of viral syndromes or used antibiotics; only one patient had a blood smear taken by a personal physician. although all patients had fever and ... | 1976 | 782238 |
| [behavior of a strain of p.berghei after low temperature preservation during more than 10 years]. | | 1975 | 782384 |