Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| pseudallescheria boydii or aspergillus fumigatus in a lady with an unresolving lung infiltrate, and a literature review. | a 53-year-old lady with blood-stained sputum and pleuritic pain had a lingular opacity on cxr which failed to resolve. a bronchial aspirate and transbronchial biopsy revealed features of bronchocentric granulomatosis with dichotomous branching hyphae suggestive of aspergillus infection. however, subsequent fungal culture grew pseudallescheria boydii. this case demonstrates the similarity of clinical and histological features caused by these two fungi. this appears to be the first reported case o ... | 2008 | 18399878 |
| [case of cutaneous pseudallescheria boydii infection caused by trauma]. | pseudallescheria boydii is a ubiquitous filamentous fungus. we report a case of cutaneous p. boydii infection of the left knee in a 79-year-old japanese man who was receiving oral predonisolone (25 mg/day) for radiation pneumonitis after radiation therapy on left breast cancer. he presented with a 2-week-history of a lesion on the left knee. a biopsy specimen from the skin lesion revealed granulomatous inflammation with hyphae. culture of the pus from the skin specimen confirmed the diagnosis of ... | 2008 | 18451593 |
| development of an immunochromatographic lateral-flow device for rapid serodiagnosis of invasive aspergillosis. | aspergillus fumigatus is a cosmopolitan saprotrophic fungus that is second only to candida species as a cause of invasive fungal infections in immunocompromised humans. current immunodiagnostic tests for invasive aspergillosis (ia) are based on the detection of circulating galactomannan (gm) in a patient's serum by using a rat monoclonal antibody (mab), eb-a2, that binds to tetra (1-->5)-beta-d-galactofuranoside, the immunodominant epitope in gm. the potential cross-reactivity of mab eb-a2 with ... | 2008 | 18463222 |
| a study of the growth of pseudallescheria boydii isolates from sewage sludge and clinical sources on tributyrin, rapeseed oil, biodiesel oil and diesel oil. | the study compared the growth of pseudallescheria boydii isolates from sewage sludge and from clinical sources on tributyrin, rapeseed oil, biodiesel oil and diesel oil agars. the isolates grew on all substrates tested. the highest growth was observed on rapeseed oil agar, while the lowest on diesel agar. on tributyrin agar, hydrolysis zones were observed around or underneath the colonies. on rapeseed oil agar, no hydrolysis zones were formed, while most isolates formed such a zone on biodiesel ... | 2008 | 18581978 |
| estimation of the biodegradation rate of 2,3,7,8-tetrachlorodibenzo-p-dioxin by using dioxin-degrading fungus, pseudallescheria boydii. | we are developing a bioreactor system for treating dioxin-contaminated soil or water using the dioxin-degrading fungus, pseudallescheria boydii (p. boydii). in order to design the bioreactor system, this study estimated the rate at which p. boydii degraded 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tcdd), which is the most toxic of the dioxins. the experimental results showed that p. boydii degraded 2,3,7,8-tcdd during its logarithmic growth phase, using glucose as a carbon source for growth, ... | 2009 | 18584955 |
| different virulence of the species of the pseudallescheria boydii complex. | pseudallescheria boydii sensu lato is a complex of species involved in severe human infections. we have evaluated, using a murine model, the virulence of 2 strains of each of the most representative species of the complex, i.e., p. boydii sensu stricto, p. minutispora, scedosporium apiospermum, s. aurantiacum and s. dehoogii. we used two different inocula, i.e., 5 x 10(4) conidia/ml (for immunosuppressed animals) and 1 x 10(6) conidia/ml (for immunocompetent animals), which were administered int ... | 2009 | 18651312 |
| isolated frontal sinusitis due to pseudallescheria boydii. | we report a case of recurrent sino-nasal fungal infection due to pseudallescheria boydii (p. boydii) in a 33-year-old diabetic woman. it is very essential to identify p. boydii, as miconazole is the only antifungal drug of choice. however, histological examination of the specimen for clinching clues such as intercalary conidia and chlamydoconidia plays an important role in identifying p. boydii, when fungal culture fails to yield the growth. on follow-up, the woman responded for the treatment wi ... | 2008 | 18723984 |
| proteins and peptidases from conidia and mycelia of scedosporium apiospermum strain hlpb. | the conidia-mycelia transformation is an essential step during the life cycle of the fungal human pathogens of the pseudallescheria boydii complex. in the present study, we have analyzed the protein and peptidase profiles in two distinct morphological stages, conidia and mycelia, of scedosporium apiospermum sensu stricto. proteins synthesized by the mycelia, migrating at the ranges of 62-48 and 22-18 kda, were not detected from the conidial extract. conidia produced a single cellular peptidase o ... | 2009 | 18726166 |
| re-identification of clinical isolates of the pseudallescheria boydii-complex involved in near-drowning. | fungal infections caused by the members of the genera pseudallescheria and/or scedosporium are important complications in patients after near-drowning. as the taxonomy of pseudallescheria and scedosporium has been revised, clinical isolates from 11 patients, after near-drowning, previously identified as p. boydii or s. apiospermum had to be re-identified. s. apiospermum, now separated from p. boydii as a distinct species, was found most frequently (n = 8), while s. aurantiacum, recently describe ... | 2008 | 18782237 |
| pseudallescheria boydii brain abscess in a renal transplant recipient: first case report in southeast asia. | pseudallescheria boydii and its asexual form, scedosporium apiospermum, are ubiquitous filamentous fungi that rarely cause central nervous system (cns) infection. brain abscess caused by p. boydii is a highly lethal infection, usually seen in organ transplant recipients who receive a number of immunosuppressive agents. we have presented a case of a 48-year-old man 6 years after renal transplantation who received methylprednisolone followed by antithymocyte globulin for treatment of acute cellula ... | 2008 | 18790255 |
| fungal endophthalmitis: fourteen years' experience from a centre in india. | background:: as fungal endophthalmitis is an emerging challenge, the study was carried out to determine the prevalence and the spectrum of fungal agents causing endophthalmitis from a single center, to identify the risk factors, and to correlate clinical course of illness with the agents involved. methods:: the microbiological and clinical records of all fungal endophthalmitis diagnosed during january 1992 through december 2005 at a tertiary center in india were reviewed retrospectively. during ... | 2008 | 18791488 |
| allescheria boydii, causative agent in a case of meningitis. | 1948 | 18902459 | |
| fungal endophthalmitis: fourteen years' experience from a center in india. | as fungal endophthalmitis is an emerging challenge, the study was carried out to determine the prevalence and the spectrum of fungal agents causing endophthalmitis from a single center, to identify the risk factors, and to correlate clinical course of illness with the agents involved. | 2008 | 19009680 |
| antifungal activity against scedosporium species and novel assays to assess antifungal pharmacodynamics against filamentous fungi. | the saprophytic moulds scedosporium prolificans and scedosporium apiospermum/pseudallescheria boydii are an increasing cause of invasive fungal infections in immunocompromised hosts. the growing importance and high mortality rates of invasive disease caused by these fungi necessitates the search for newer treatment strategies. however, clinically available antifungal agents have modest to minimal activity against these organisms that has been confirmed by suboptimal responses in the clinic. due ... | 2009 | 19058049 |
| ecology of pseudallescheria and scedosporium species in human-dominated and natural environments and their distribution in clinical samples. | this study aims to determine the occurrence of pseudallescheria and scedosporium species in natural and human-dominated environments. habitats (136 sampling sites) in a transect with increasing human impact were investigated (natural areas, agricultural soils, urban playgrounds, industrial areas). physico-chemical parameters were measured to characterize the different areas included in this investigation. fungal identification was performed by morphology and sequence data analysis. comparative d ... | 2009 | 19085459 |
| in vitro activities of isavuconazole against opportunistic filamentous and dimorphic fungi. | the in vitro activity of isavuconazole was compared to those of amphotericin b, fluconazole, itraconazole, voriconazole, posaconazole, and ravuconazole against 300 clinical isolates of pseudallescheria boydii, paecilomyces lilacinus, fusarium spp., bipolaris spicifera, curvularia lunata, alternaria alternata, exophiala spp., rhizopus arrhizus, mucor circillenoides, absidia corymbifera, blastomyces dermatitidis, histoplasma capsulatum and coccidioides posadasii. mics were determined by a broth ma ... | 2009 | 19101837 |
| biochemical characterization of potential virulence markers in the human fungal pathogen pseudallescheria boydii. | the ubiquitous pseudallescheria boydii (anamorph scedosporium apiospermum) is a saprophytic filamentous fungus recognized as a potent etiologic agent of a wide variety of infections in immunocompromised as well as in immunocompetent patients. very little is known about the virulence factors expressed by this fungal pathogen. the present review provides an overview of recent discoveries related to the identification and biochemical characterization of potential virulence attributes produced by p. ... | 2009 | 19235547 |
| fatal mycotic aneurysm caused by pseudallescheria boydii after near drowning. | pseudallescheria boydii is a rare cause of mycotic infection. factors predisposing to systemic infection include traumas, immunosuppression, and near drowning. we report a case of multiple aneurysms caused by this hyalohyphomycete, occurred after near drowning. the car driven by a 53-year-old woman plunged into a canal in the netherlands. after a 20-min-long submersion, the woman was rescued. at hospital, a severe aspiration of muddy water and a mycotic pneumonia were diagnosed. despite the imme ... | 2010 | 19294403 |
| a review of german scedosporium prolificans cases from 1993 to 2007. | scedosporium prolificans is one of the most life-threatening fungal opportunistic pathogens due to its high resistance to common systemic antifungal agents. while a close relative of pseudallescheria boydii, s. prolificans has a more limited geographic range being primarily found in australia, usa and spain. infections have also been reported from several other european countries and from chile. twenty patients with scedosporium prolificans infection or colonization from august 1993 to may 2007 ... | 2009 | 19301173 |
| tracking the emerging human pathogen pseudallescheria boydii by using highly specific monoclonal antibodies. | pseudallescheria boydii has long been known to cause white grain mycetoma in immunocompetent humans, but it has recently emerged as an opportunistic pathogen of humans, causing potentially fatal invasive infections in immunocompromised individuals and evacuees of natural disasters, such as tsunamis and hurricanes. the diagnosis of p. boydii is problematic since it exhibits morphological characteristics similar to those of other hyaline fungi that cause infectious diseases, such as aspergillus fu ... | 2009 | 19321690 |
| pseudallescheria boydii (scedosporium species) in 3 lung transplant recipients: computed tomography findings and literature review. | objective: the objective of our study was to evaluate chest computed tomography (ct) findings in 3 lung transplant recipients infected with pseudallescheria boydii complex or its asexual anamorph, scedosporium apiospermum, 2 after double-lung transplant and 1 after single-lung transplantation. awareness and early diagnosis of this rare but potentially lethal infection are important, as it is largely refractory to treatment with the antifungal agents of choice used for the more common aspergillus ... | 2009 | 19346854 |
| tricuspid valve and pacemaker endocarditis due to pseudallescheria boydii (scedosporium apiospermum). | we report a case of native valve and pacemaker endocarditis in a 78-year-old male with diabetes mellitus who died after cardiac surgery. at autopsy, tricuspid valve vegetations and lung abscesses containing thick, hyaline, septate, and branching hyphae were present. the culture identified scedosporium apiospermum, an infrequent cause of opportunistic infections in immunocompromised hosts. | 2009 | 19373137 |
| heterothallism in scedosporium apiospermum and description of its teleomorph pseudallescheria apiosperma sp. nov. | scedosporium apiospermum has traditionally been thought of as the anamorph of pseudallescheria boydii (microascaceae, ascomycota), but recent molecular studies has demonstrated that they are different species. since a teleomorph was not observed among isolates recently identified as s. apiospermum, we investigated whether this species could be heterothallic. in this study, 15 isolates of s. apiospermum were paired in all possible combinations, including self-pairings. several combinations produc ... | 2010 | 19418347 |
| population-based surveillance for scedosporiosis in australia: epidemiology, disease manifestations and emergence of scedosporium aurantiacum infection. | australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. predisposing factors for isolation of scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. predictors of invasive disease (n=62) included haematological stem cell transplantation (n=7), leukaemia (n=16) and diabetes mellitus (n=8). of 183 phenotypically-speciated isolates, 75 (41%) were scedosporium p ... | 2009 | 19549223 |
| deep, respiratory tract and ear infections caused by pseudallescheria (scedosporium) and microascus (scopulariopsis) in finland. a 10-year retrospective multi-center study. | deep, respiratory tract and ear infections due to microascaceae (pseudallescheria, scedosporium, microascus or scopulariopsis) were studied nationwide in finland during 1993-2002. the data were based on 52,000 fungal cultures that represented about 50% of all such specimens in finland and included all finnish cases of profound immunosuppression. there were 39 cases that were re-evaluated as clinically significant, i.e., three pneumonias, two deep pedal infections and five wound infections, 11 si ... | 2010 | 19672782 |
| production of a fungistatic substance by pseudallescheria boydii isolated from soil amended with vegetable tissues and its significance. | four fungal isolates that were able to use vegetable tissues for multiplication in soil were isolated and identified as pseudallescheria boydii based on morphological characteristics and its sequence similarity. when grown in broth prepared from the same vegetable tissues used in soil amendment, all these isolates of p. boydii produced a substance capable of reducing the disease incidence of black leaf spot of spoon cabbage caused by alternaria brassicicola and inhibiting the germination of a. b ... | 2010 | 19760090 |
| multiple subcutaneous mycetomas caused by pseudallescheria boydii: response to therapy with oral potassium iodide solution. | we describe the case of a sixteen-year-old male who presented with multiple subcutaneous mycetomas proven on culture to be secondary to pseudallescheria boydi., the lesions responded completely to oral potassium iodide solution. to our knowledge this has never been reported in humans. | 2010 | 19761792 |
| disseminated pseudallescheriosis in a dog. | a case of disseminated pseudallescheriasis in a german shepherd bitch is presented. bones (ilium, a rib and phalanges), joints (elbow and acetabulum) and the surrounding tissues were the principal organs affected. in addition, pseudallescheria boydii was isolated, in lower numbers, from the eye, kidney, lymph nodes draining the affected regions and urine. the dog was euthanized. p. boydii was identified by morphologic characteristics and molecular techniques (beta tubulin sequence). in addition, ... | 2010 | 19886774 |
| invasive infection caused by pseudallescheria boydii in an immunocompetent patient. | pseudallescheria boydii is a saprophytic fungus frequently isolated from agricultural soil and polluted water. disseminated and invasive infections with this organism are seen primarily in the immunocompromised host. we present an unusual case of invasive p. boydii infection in an immunocompetent patient admitted to our hospital with clinical, laboratory and ecg findings of a possible acute myocardiac infarction. six hours after admission without treatment with thrombolytic agents she presented ... | 2009 | 19918311 |
| cutaneous pseudallescheria boydii infection in a renal transplant patient: a case report. | we describe the case of a 59-year-old male renal transplant recipient who presented with a 1 month history of nodular, erythematous, and crusted lesions on the anterior surface of the left leg. there was no history of trauma. the patient had no systemic signs or symptoms. a skin biopsy revealed evidence of a deep fungal infection, with septate and branching hyphae amongst the dermal inflammatory infiltrate, but the culture was negative. initial treatment with itraconazole proved ineffective and ... | 2009 | 19951626 |
| disseminated scedosporium/pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis. | we report a case of disseminated scedosporium/pseudallescheria infection due to pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis. dissemination occurred under voriconazole. despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. previously reported cases are reviewed. | 2010 | 20220160 |
| pharmacokinetic/pharmacodynamic profile of posaconazole. | posaconazole is a recently approved lipophilic triazole antifungal agent that exhibits potent and broad-spectrum antifungal activity in vitro and in vivo against most candida spp., cryptococcus neoformans, aspergillus spp., many zygomycetes, endemic fungi and dermatophytes. it has been documented that posaconazole has potency and spectrum of activity similar to those of itraconazole and superior to those of fluconazole against clinically important isolates of candida spp., c. neoformans and aspe ... | 2010 | 20481649 |
| human and animal isolates of pseudallescheria boydii and scedosporium species, from melbourne, australia, 1977-1995. | from 1977 to 1995, 25 of the fungal cultures referred to the microbiological diagnostic unit public health laboratory at the university of melbourne, victoria, australia were identified as scedosporium apiospermum, pseudallescheria boydii, or scedosporium prolificans. these cultures had been isolated from 22 patients at metropolitan hospitals and three animals at veterinary institutes. eight of the human isolates were identified as p. boydii, 11 as s. apiospermum and three as s. prolificans. iso ... | 2010 | 20492531 |
| characterization of pseudacyclins a-e, a suite of cyclic peptides produced by pseudallescheria boydii. | pseudallescheria boydii sensu lato is an emerging fungal pathogen causing fatal infections in both immunocompromised and immunocompetent hosts. in this work, two p. boydii isolates (human and animal origin) have been identified as being producers of cyclic peptides. five putative nonribosomal peptides with a unique structure, which have been named pseudacyclins, were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. the most abundant representative of the pseudacycl ... | 2010 | 20509707 |
| experimental murine scedosporiosis: histopathology and azole treatment. | the histopathology of clinical isolates of scedosporium apiospermum, scedosporium boydii, and scedosporium aurantiacum in immunosuppressed mice was evaluated. the organs most affected were the brain, kidneys, and spleen. s. aurantiacum produced more tissue damage than the other two species. amphotericin b (amb) was ineffective in the treatment of murine infections caused by such isolates, and posaconazole and voriconazole showed efficacy that correlated with the in vitro susceptibility data. | 2010 | 20547805 |
| infections caused by fungi of the scedosporium/pseudallescheria complex in veterinary species. | fungi belonging to the scedosporium/pseudallescheria complex (spcf) have been known to cause human infections for nearly a century and are important human pathogens, with an increasing frequency of infection in patients with underlying conditions. there appears to be a lower incidence of infections with spcf in veterinary species, although this may be related to a lack of awareness of these diseases. important recent taxonomic changes in this group of fungi include the classification of pseudall ... | 2011 | 20580291 |
| successful treatment of pseudallescheria boydii keratitis with topical natamycin as monotherapy. | to report a case of pseudallescheria boydii keratitis successfully treated with topical natamycin as monotherapy. | 2010 | 20925580 |
| tlr4 recognizes pseudallescheria boydii conidia and purified rhamnomannans. | pseudallescheria boydii (scedosporium apiospermum) is a saprophytic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections, particularly mycetoma, in immunocompromised and immunocompetent hosts. we have previously shown that highly purified α-glucan from p. boydii activates macrophages through toll-like receptor tlr2, however, the mechanism of p. boydii recognition by macrophage is largely unknown. in this work, we investigated ... | 2010 | 20959459 |
| clinical associations and prevalence of scedosporium spp. in australian cystic fibrosis patients: identification of novel risk factors? | risk factors for the association of scedosporium in cases of cystic fibrosis (cf) and its clinical implications are poorly understood. clinical, lung function and laboratory data of adult cf patients in sydney (april 2008-march 2009) were prospectively analysed for such risk factors. expectorated sputa were cultured for bacteria and examined for fungi using standard mycological and scedosporium-selective media, and by an internal transcribed spacer region-targeted multiplex pcr assay. scedospori ... | 2010 | 21067328 |
| lack of standardization in the procedures for mycological examination of sputum samples from cf patients: a possible cause for variations in the prevalence of filamentous fungi. | filamentous fungi and yeasts are increasingly isolated from respiratory secretions of patients with cystic fibrosis (cf), and persistent fungal colonization of the airways of such patients is thought to exacerbate lung damage. while many independent studies have identified aspergillus fumigatus complex as the principal colonizing fungus in cf, increased awareness of the role of fungi in cf pathology coupled with improved mycological culture and identification methods have resulted in a number of ... | 2010 | 21067335 |
| identification of fusarium species in formalin-fixed and paraffin-embedded sections by in situ hybridization using peptide nucleic acid probes. | fusarium has recently emerged as an opportunistic pathogen of humans, but the histological differentiation of fusarium from aspergillus and scedosporium is particularly difficult because these fungi may induce similar clinical features and exhibit filamentous development in host tissues. thus, there is a need to establish rapid and reliable methods that are applicable to pathological diagnoses. the aim of this study was to evaluate and establish in situ hybridization (ish) using peptide nucleic ... | 2010 | 21106796 |
| discrimination of scedosporium prolificans against pseudallescheria boydii and scedosporium apiospermum by semiautomated repetitive sequence-based pcr. | the laboratory identification of pseudallescheria and scedosporium isolates at the species level is important for clinical and epidemiological purposes. this study used semiautomated repetitive sequence-based polymerase chain reaction (rep-pcr) to identify pseudallescheria/scedosporium. reference strains of pseudallescheria boydii (n = 12), scedosporium prolificans (n = 8), scedosporium apiospermum (n = 9), and clinical/environmental isolates (p. boydii, 7; s. prolificans, 7; s. apiospermum, 7) ... | 2010 | 21108573 |
| ocular complications in patients with lung transplants. | aim to describe infectious and non-infectious ocular complications found in patients with lung transplants. methods 545 patients underwent lung transplantation from january 1998 to september 2008 at the cleveland clinic. patients who underwent ophthalmic examination at the cole eye institute after lung transplantation were included in the study. outcomes diagnoses, treatments, surgeries, laboratory parameters of immune status and patient survival were examined. results of the 545 patients who re ... | 2010 | 21131376 |
| identification of pseudallescheria and scedosporium species by three molecular methods. | the major clinically relevant species in scedosporium (teleomorph pseudallescheria) are pseudallescheria boydii, scedosporium aurantiacum, scedosporium apiospermum, and scedosporium prolificans, while pseudallescheria minutispora, petriellopsis desertorum, and scedosporium dehoogii are exceptional agents of disease. three molecular methods targeting the partial β-tubulin gene were developed and evaluated to identify six closely related species of the s. apiospermum complex using quantitative rea ... | 2010 | 21177887 |
| is hypogammaglobulinemia a constant feature in good's syndrome? | thymomas are rare tumors, which can be associated to a variety of paraneoplastic syndromes, including a fatal hypogammaglobulinemia, namely good?s syndrome (gs). although the combination of thymoma and hypogammaglobulinemia is regarded as sufficient for diagnosis of good?s syndrome, some thymoma patients with a clear clinical picture of immunodeficiency present normal levels of immunoglobulins. we describe the case of a patient, with a 20-year history of thymoma, who underwent several operations ... | 2010 | 21244779 |
| subconjunctival mycetoma caused by scedosporium apiospermum infection in a horse. | an 11-year-old american saddlebred gelding was presented for evaluation of a nonpainful subconjunctival mass involving the lateral canthus of the left eye. other findings included a central corneal scar and a small central cataract of the lens in the left eye. fine-needle aspiration of the mass was performed and cytologic examination revealed marked pyogranulomatous inflammation with intralesional fungal hyphae, consistent with mycetoma. the fungal structures were elongated and characterized by ... | 2011 | 21291482 |
| development and validation of a multiplex pcr for detection of scedosporium spp. in respiratory tract specimens from patients with cystic fibrosis. | the emergence of scedosporium infections in diverse groups of individuals, which are often treatment refractory, warrants timely and accurate laboratory diagnosis. species- or group-specific primers based on internal transcribed spacer (its) sequence polymorphisms were designed for scedosporium aurantiacum, scedosporium dehoogii, scedosporium prolificans, pseudallescheria boydii species complex (former clade 5)/pseudallescheria apiosperma (formerly classified as s. apiospermum sensu lato) and ps ... | 2011 | 21325557 |
| fatal mycotic aneurysms due to scedosporium and pseudallescheria infection. | angioinvasive complications of scedosporium infections are rare. we report two cases of mycotic aneurysm, following apparent localized infection, due to scedosporium apiospermum and pseudallescheria boydii. the thoracoabdominal aorta was affected in one patient, and cerebral vessels were affected in the other. despite voriconazole therapy and surgical resection, the patients died. previously reported cases are reviewed. | 2011 | 21430108 |
| pseudallescheria boydii lung infection in an immunocompetent adult, difficulties in diagnosis and management. | pseudallescheria boydii and its asexual state scedosporium apiospermum is a well known opportunistic pathogen among immunocompromised patients. however it is rare in immunocompetent patients. the optimum management of this infection is still not clear. the new azoles may show better efficacy than amphotericin b and additional surgery may play a pivotal role. we report a case of pseudallescheria boydii lung infection in an immunocompetent patient who had an old tuberculous cavity and presumed inh ... | 2010 | 21510115 |
| infections due to pseudallescheria/scedosporium species in patients with advanced hiv disease - a diagnostic and therapeutic challenge. | : the aim of this study is to highlight the importance of infections caused by members of the genera pseudallescheria/scedosporium in hiv-positive patients. | 2011 | 21511507 |
| pseudallescheria boydii infection of a prosthetic hip joint-an uncommon infection in a rare location. | pseudallescheria boydii infection of the hip joint was diagnosed 2.5 years after implantation of a prosthetic joint in a woman with rheumatoid arthritis. cure was achieved with a 10-month course of voriconazole coupled with removal of the prosthesis and repeat surgical debridement. pseudallescheria boydii is an environmental mold that can cause osteoarticular infection, most often not only after local trauma but also after local injections and surgical procedures. hip involvement was rarely repo ... | 2011 | 21681069 |
| management and outcome of microbial anterior scleritis. | : to evaluate the prevalence, predisposing factors, and outcomes of bacterial and fungal scleritis. | 2011 | 21694595 |
| in vitro antifungal activity of e1210, a novel antifungal, against clinically important yeasts and moulds. | e1210 is a new antifungal compound with a novel mechanism of action and broad-spectrum of antifungal activity. we investigated the in vitro antifungal activity of e1210 compared to that of fluconazole, itraconazole, voriconazole, amphotericin b, and micafungin against clinical fungal isolates. e1210 showed potent activity against most candida spp. (mic(90) of ôëñ0.008 to 0.06 ++g/ml) except for candida krusei (mics of 2 to >32 ++g/ml). e1210 showed equally potent activity against fluconazole-res ... | 2011 | 21825291 |
| pseudallescheria boydii species complex fungal rhinitis and sinusitis in a dog. | a 9 yr old male castrated australian shepherd mixed-breed dog with a 3 mo history of intermittent unilateral epistaxis was diagnosed with pseudallescheria boydii species complex fungal rhinitis and sinusitis. this fungal organism is a rare cause of disease in dogs and an emerging human pathogen. the dog was successfully treated with topical clotrimazole. | 2011 | 21852515 |
| tenosynovitis caused by a pseudallescheria boydii infection and symptoms of reflex sympathetic dystrophy after a dog bite. | tenosynovitis caused by a pseudallescheria boydii infection is an extremely rare complication after a dog bite and is easily misdiagnosed, leading to a delay in treatment. careful history taking and adequate cultures can lead to a timely diagnosis, and longstanding antimycotic treatment can successfully eradicate the fungus. | 2011 | 21946460 |
| reverse line blot hybridisation screening of pseudallescheria/scedosporium species in patients with cystic fibrosis. | the pcr-rlb (reverse line blot hybridisation) was applied as a molecular technique for the detection of members of pseudallescheria and scedosporium from sputum of patients with cystic fibrosis (cf). fifty-nine sputum samples were collected from 52 cf patients, which were analysed by culture and pcr-rlb. conventional and semi-selective culture yielded five positive samples, but the pcr-rlb hybridisation assay permitted the detection of members of pseudallescheria/scedosporium in 32 out of 52 pat ... | 2011 | 21995657 |
| infection and colonisation due to scedosporium in northern spain. an in vitro antifungal susceptibility and molecular epidemiology study of 60 isolates. | since the latest taxonomical changes in the genus scedosporium by gilgado et al. in 2010, no species-specific studies on epidemiology and antifungal susceptibility patterns (afsp) have so far been published. this study aimed to provide qualitative epidemiological data of scedosporium spp. isolated from cystic fibrosis (cf) patients and immunocompromised patients from northern spain. isolates were identified by using amplified fragment length polymorphism (aflp), and species-specific afsp were ge ... | 2011 | 21995658 |
| glycoconjugates and polysaccharides from the scedosporium/pseudallescheria boydii complex: structural characterisation, involvement in cell differentiation, cell recognition and virulence. | peptidorhamnomannans (prms), rhamnomannans and α-glucans are especially relevant for the architecture of the scedosporium/pseudallescheria boydii cell wall, but many of them are immunologically active, with great potential as regulators of pathogenesis and the immune response of the host. in addition, some of them can be specifically recognised by antibodies from the sera of patients, suggesting that they could also be useful in diagnosis of fungal infections. their primary structures have been ... | 2011 | 21995660 |
| scedosporium and pseudallescheria low molecular weight metabolites revealed by database search. | the potential of mmass software search tool with new compound libraries was demonstrated on metabolomics of scedosporium prolificans, s. apiospermum and pseudallescheria boydii sensu stricto. cyclic peptides pseudacyclins, small molecular weight tyroscherin analogues and various lipids were annotated by public software tool (http://www.mmass.org) utilising accurate matrix-assisted laser desorption/ionisation mass spectral data of intact fungal spores. electrospray ionisation combined with tandem ... | 2011 | 21995661 |
| phylogeny and immune evasion: a putative correlation for cerebral pseudallescheria/scedosporium infections. | representatives of the genus pseudallescheria (anamorph: scedosporium) are saprobes and the aetiologic agent of invasive mycosis in humans. after dissemination, the central nervous system (cns) is one of the most affected organs. prerequisites for the survival of pseudallescheria/scedosporium in the host are the ability to acquire nutrients and to evade the immune attack. the cleavage of complement compounds via the secretion of fungal proteases might meet both challenges since proteolytic degra ... | 2011 | 21995663 |
| a case of cutaneous scedosporium infection in an immunocompromised patient. | scedosporium apiospermum, the asexual stage of pseudoallescheria boydii, is a fungus ubiquitous in soil as well as organically polluted areas, where nitrogen-containing compounds are abundant. it is an emerging opportunistic pathogen that can range from cutaneous to disseminated infection and can be fatal within months of diagnosis. here we present a case of disseminated s. apiospermum infection with cutaneous manifestations in a 59-year-old woman with myelodysplastic syndrome, in remission from ... | 2011 | 22032175 |
| Rapid identification of pseudallescheria and scedosporium strains by using rolling circle amplification. | The Pseudallescheria boydii complex, comprising environmental pathogens with Scedosporium anamorphs, has recently been subdivided into five main species: Scedosporium dehoogii, S. aurantiacum, Pseudallescheria minutispora, P. apiosperma, and P. boydii, while the validity of some other taxa is being debated. Several Pseudallescheria and Scedosporium species are indicator organisms of pollution in soil and water. Scedosporium dehoogii in particular is enriched in soils contaminated by aliphatic hy ... | 2012 | 22057865 |
| proteomic analysis of the secretions of pseudallescheria boydii, a human fungal pathogen with unknown genome. | pseudallescheria boydii is a filamentous fungus that causes a wide array of infections that can affect practically all the organs of the human body. the treatment of pseudallescheriosis is difficult since p. boydii exhibits intrinsic resistance to the majority of antifungal drugs used in the clinic and the virulence attributes expressed by this fungus are unknown. the study of the secretion of molecules is an important approach for understanding the pathogenicity of fungi. with this task in mind ... | 2011 | 22142336 |
| structural analysis of fungal cerebrosides. | of the ceramide monohexosides (cmhs), gluco- and galactosyl-ceramides are the main neutral glycosphingolipids expressed in fungal cells. their structural determination is greatly dependent on the use of mass spectrometric techniques, including fast atom bombardment-mass spectrometry, electrospray ionization, and energy collision-induced dissociation mass spectrometry. nuclear magnetic resonance has also been used successfully. such a combination of techniques, combined with classical analytical ... | 2011 | 22164155 |
| maduromycosis "allescheria boydii" septic arthritis of the knee: a case report. | septic arthritis due to fungal agents is rare in temperate climates such as the united states, and maduromycosis due to auescheria boydii is especially uncommon. of the 21 previously reported cases, only two involved the knee j'oint. reported here is a case of allescheria hoyan infection of the left knee of a 5-yearold girl, with eventual successful cure by a combination of surgical synovectomy and amphotericin b chemotherapy. | 1981 | 24823095 |
| assessing micafungin/triazole combinations for the treatment of invasive scedosporiosis due to scedosporium apiospermum and scedosporium boydii. | scedosporium infections are associated with high therapeutic failure rates. combination therapy may be an alternative approach to improve outcome. the in vitro and in vivo efficacy of micafungin plus posaconazole or plus voriconazole was investigated herein. | 2014 | 24986494 |
| susceptibility and diversity in the therapy-refractory genus scedosporium. | scedosporium species show decreased susceptibility to the majority of systemic antifungal drugs. acquired resistance is likely to disseminate differentially with the mode of exchange of genetic material between lineages. inter- and intraspecific diversities of scedosporium species were analyzed for three partitions (rdna internal transcribed spacer gene [its], partial β-tubulin gene, and amplified fragment length polymorphism profiles), with the aim to establish distribution of resistance betwee ... | 2014 | 25070092 |
| mycetoma: experience of 482 cases in a single center in mexico. | mycetoma is a chronic granulomatous disease. it is classified into eumycetoma caused by fungi and actinomycetoma due to filamentous actinomycetes. mycetoma can be found in geographic areas in close proximity to the tropic of cancer. mexico is one of the countries in which this disease is highly endemic. in this retrospective study we report epidemiologic, clinical and microbiologic data of mycetoma observed in the general hospital of mexico in a 33 year-period (1980 to 2013). a total of 482 case ... | 2014 | 25144462 |
| purification and characterization of a mycelial catalase from scedosporium boydii, a useful tool for specific antibody detection in patients with cystic fibrosis. | scedosporium boydii is an opportunistic filamentous fungus which may be responsible for a wide variety of infections in immunocompetent and immunocompromised individuals. this fungus belongs to the scedosporium apiospermum species complex, which usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (cf) and may lead to allergic bronchopulmonary mycoses, sensitization, or respiratory infections. upon microbial infection, host phagocytic cells rel ... | 2015 | 25355796 |
| successful long-term management of invasive cerebral fungal infection following liver transplantation. | central nervous system (cns) infections after liver transplantation may be fungal in aetiology, with involvement from either common organisms such as cryptococcus neoformans and aspergillus spp. as well as less common organisms, such as the mucorales and scedosporium spp. although the mortality of cns fungal infections was nearly 100% in early series, more recent data has suggested that good outcomes can be achieved. this may be due to both improved diagnostic capabilities, such as the ability t ... | 2015 | 25590987 |
| a multifaceted study of scedosporium boydii cell wall changes during germination and identification of gpi-anchored proteins. | scedosporium boydii is a pathogenic filamentous fungus that causes a wide range of human infections, notably respiratory infections in patients with cystic fibrosis. the development of new therapeutic strategies targeting s. boydii necessitates a better understanding of the physiology of this fungus and the identification of new molecular targets. in this work, we studied the conidium-to-germ tube transition using a variety of techniques including scanning and transmission electron microscopy, a ... | 2015 | 26038837 |
| n-chlorotaurine exhibits fungicidal activity against therapy-refractory scedosporium species and lomentospora prolificans. | n-chlorotaurine (nct), a well-tolerated endogenous long-lived oxidant that can be applied topically as an antiseptic, was tested on its fungicidal activity against scedosporium and lomentospora, opportunistic fungi that cause severe infections with limited treatment options, mainly in immunocompromised patients. in quantitative killing assays, both hyphae and conidia of scedosporium apiospermum, scedosporium boydii, and lomentospora prolificans (formerly scedosporium prolificans) were killed by ... | 2015 | 26239996 |
| cluster analysis of scedosporium boydii infections in a single hospital. | scedosporiosis is a rare, but often fatal mycotic infection occurring in immunosuppressed as well as in immunocompetent patients. over a period of 14 months, scedosporium boydii isolates were sent to our reference laboratory from six immunocompetent patients treated at a single hospital in germany. in analogy to the eortc/msg criteria, four patients were classified as proven invasive scedosporiosis cases, and two patients as probable or possible cases. of note, in five patients scedosporiosis wa ... | 2015 | 26330287 |
| semi-automated repetitive sequence-based pcr amplification for species of the scedosporium apiospermum complex. | the scedosporium apiospermum species complex usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (cf), but little is known about the molecular epidemiology of the airway colonization. | 2016 | 26486722 |
| identification of scedosporium boydii catalase a1 gene, a reactive oxygen species detoxification factor highly expressed in response to oxidative stress and phagocytic cells. | scedosporium boydii is an opportunistic filamentous fungus which may be responsible for a large variety of infections in both immunocompetent and immunocompromised individuals. this fungus belongs to the scedosporium apiospermum species complex which usually ranks second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (cf). species of the s. apiospermum complex are able to chronically colonize the cf airways suggesting pathogenic mechanisms allowing persistenc ... | 2015 | 26615753 |
| the 'species complex' issue in clinically relevant fungi: a case study in scedosporium apiospermum. | the genus scedosporium currently comprises six species, scedosporium apiospermum, scedosporium boydii, pseudallescheria angusta, scedosporium minutisporum, scedosporium dehoogii, and scedosporium aurantiacum, most of which can be distinguished with the primary fungal dna barcode, the its1/2 region of the rdna gene cluster. in the present study, four additional genetic loci were explored from a phylogenetic point of view enabling a barcoding approach based on k2p pairwise distances to resolve the ... | 2016 | 26781369 |
| discriminative potential of some pcr-based and biochemical methods at scedosporium strains. | three innovative pcr-based methods (fluorescent-its, fluorescent-cbh and its-pcr dgge) were tested using a reference set of nine strains of scedosporium from the cbs fungal collection. cellulolytic, lipolytic and proteolytic potential and the ability to dissolve caco3 of the strains were evaluated in vitro by means of agar assays. f-its profiles almost recognized main species, although included "pseudallescheria" ellipsoidea and the scedosporium boydii cbs 117432 and cbs 120157 in the same clust ... | 2016 | 26781371 |
| towards proteomic species barcoding of fungi - an example using scedosporium/pseudallescheria complex isolates. | maldi-tof mass spectrometry offers fast and reliable species identification for bacteria and yeasts under clinical routine conditions. here, we produced mass spectra for identification of clinically important species of the pseudallescheria/scedosporium complex using the recently suggested new nomenclature and use this example to discuss to what extent the principle of dna barcoding might be transferred to mass spectrometry. | 2016 | 26781372 |
| endophthalmitis of probable endogenous origin caused by scedosporium boydii: a case report. | mycotic ocular infections caused by the scedosporium apiospermum species complex are challenging to treat because of the delayed diagnoses and poor responses to antifungal drugs and surgical treatment. | 2016 | 26874584 |
| new record of scedosporium dehoogii from chile: phylogeny and susceptibility profiles to classic and novel putative antifungal agents. | scedosporium species are considered emerging agents causing illness in immunocompromised patients. in chile, only scedosporium apiospermum, scedosporium boydii and lomentospora prolificans haven been reported previously. | 2016 | 27461998 |
| bactericidal and fungicidal activity of n-chlorotaurine is enhanced in cystic fibrosis sputum medium. | lung infections with multiresistant pathogens are a major problem of patients suffering from cystic fibrosis (cf). n-chlorotaurine (nct), a microbicidal active chlorine compound with no resistance development, is well tolerated upon inhalation. the aim of this study was to investigate nct on its bactericidal and fungicidal activity in vitro in artificial sputum medium (asm) mimicking the composition of cystic fibrosis mucus.the medium was inoculated with bacteria (staphylococcus aureus including ... | 2017 | 28223376 |
| dihydroorotate dehydrogenase inhibitor f901318 has potent in vitro activity against scedosporium species and lomentospora prolificans. | scedosporium species and lomentospora prolificans are increasing causes of invasive infections in immunocompromised hosts and many isolates are resistant to available antifungals. our objective was to assess the in vitro potency of f901318, a member of the orotomide class of antifungals, against scedosporium species and l. prolificans . | 2017 | 28333310 |