Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi. | the purpose of the study was to evaluate the interlaboratory agreement of broth dilution susceptibility methods for five species of conidium-forming (size range, 2 to 7 microns) filamentous fungi. the methods used included both macro- and microdilution methods that were adaptations of the proposed reference method of the national committee for clinical laboratory standards for yeasts (m27-p). the mics of amphotericin b, fluconazole, itraconazole, miconazole, and ketoconazole were determined in s ... | 1995 | 7726488 |
| ribosomal dna internal transcribed spacer analysis supports synonomy of scedosporium inflatum and lomentospora prolificans. | scedosporium inflatum is a dematiaceous opportunistic pathogen originally described by d. malloch and i.f. salkin (mycotaxon 21:247-255, 1984). however, e. gueho and g. s. de hoog (j. mycol. med. 118:3-9, 1991) recently suggested reducing this mold to synonomy with lomentospora prolificans on the basis of their similar morphological and molecular characteristics. we have investigated the ribosomal dna internal transcribed spacers (its), i.e., its i and its ii, of 18 isolates, including these two ... | 1994 | 7814476 |
| rapid method for detection of aspergillus 5s ribosomal rna using a genus-specific oligonucleotide probe. | ribosomal rna (rrna) is present in all prokaryotic and eukaryotic cells. although sequences are conserved, variations in nucleic acid composition are known to be species specific. formalin or bouin's fixed, paraffin-embedded tissue specimens from 17 cases of culture proven aspergillus sp infections were studied by a rapid (< 30 minutes) in situ hybridization procedure using a biotinylated oligonucleotide dna probe complementary to nucleic acids 1-22 of aspergillus sp 5s rrna sequence. positivity ... | 1995 | 7817944 |
| invasive pulmonary pseudallescheriasis with direct invasion of the thoracic spine in an immunocompetent patient. | most invasive pseudallescheriasis infections have occurred in immunocompromised patients. the case of an immunocompetent patient with invasive pulmonary pseudallescheriasis and subsequent contiguous extension to the ribs and spine is reported. aspergillosis was mistakenly diagnosed on histopathologic examination of the debrided tissue. culture of the debrided tissue yielded pseudallescheria boydii. | 1994 | 7843180 |
| phylogeny of dermatophytes and dimorphic fungi based on large subunit ribosomal rna sequence comparisons. | the phylogeny of dermatophytes and dimorphic fungi was considered using the large-subunit of ribosomal rna (25s rrna). aligned sequences of 595 nucleotides covering the two most divergent domains d1 and d2, permitted a comparison of phylogenetic relationships at different levels. the dimorphic species (onygenaceae) were significantly separated from dermatophytes (arthrodermataceae) and from a third group including geophilic or very weakly pathogenic species (onygenaceae and gymnoascaceae). on a ... | 1994 | 7844699 |
| ecology and physiology of the emerging opportunistic fungi pseudallescheria boydii and scedosporium prolificans. | nutritionally physiological patterns of pseudallescheria boydii (microascaceae) and the related species scedosporium prolificans were established. differences between the two species were found in assimilation of sucrose, ribitol, xylitol and l-arabinitol. in contrast, no physiological distinction could be made between the three intraspecific variants of p. boydii which have been recognized on the basis of ndna/dna homology data and of morphological and clinical differences. some potential virul ... | 1994 | 7845423 |
| prevalence of fungal corneal ulcers in northern india. | fungal corneal ulcer is common in india due to the tropical climate and a large agrarian population that is at risk. various factors such as trauma, the injudicious use of topical antibiotics and corticosteroids are involved. many of the age and sex-related risk factors also play a minor role. this 6-year study from northern india revealed that fungi were detected in 61 (8.4%) out of 730 patients investigated. direct microscopy was positive in 51 (7%) and culture in 53 (7.3%) patients. aspergill ... | 1994 | 7927819 |
| fungal panophthalmitis secondary to scedosporium apiospermum (pseudallescheria boydii) keratitis. | 1994 | 7943139 | |
| lumbar petriellidium boydii osteomyelitis with a systemic presentation. | 1994 | 7949705 | |
| fungal arthritis due to pseudallescheria boydii (scedosporium apiospermum). | musculoskeletal infections by fungal agents are uncommon conditions. pseudallescheria boydii is an ubiquitous saprophytic fungus frequently involved in maduromycosis but rarely in septic arthritis. we describe a case of pseudallescheria boydii destructive suppurative arthritis and osteomyelitis of the knee in an adult guadeloupean man. osteoarticular infections due to pseudallescheria boydii are reviewed. | 1994 | 8035409 |
| subcutaneous pseudallescheriasis in a renal transplant recipient. | this paper reports a case of a single subcutaneous nodule caused by pseudallescheria boydii in a renal transplant recipient, possibly of nontraumatic origin. the patient was treated surgically and with itraconazole. | 1994 | 8047106 |
| [pseudallescheria boydii fungal endophthalmitis. 6 years after trabeculectomy]. | a case is reported of a 67-year-old female patient, in whom a fungal endophthalmitis occurred 6 years after trabeculectomy. pseudallescheria boydii was isolated. this organism is a rare cause of infection. in the literature only 14 cases of keratitis and 8 cases of endophthalmitis have been reported. miconazole is the therapy of choice. however in 55% of the published cases, (as in the one reported here), an exenteration or enucleation of the affected bulbus was necessary. | 1994 | 8051902 |
| treatment of tropical mycoses. | several subcutaneous and deep-seated mycoses are either observed more frequently in the tropical areas or are restricted to certain regions within the tropics. these mycoses include sporotichosis, chromoblastomycosis, entomophthoromycosis, eumycetoma, lobomycosis, and paracoccidioidomycosis. in sporotrichosis and paracoccidioidomycosis, therapy often results in either complete resolution or marked improvement. for decades sporotrichosis has been treated successfully with potassium iodide, but re ... | 1994 | 8077517 |
| fungal sinusitis in patients with aids: report of 4 cases and review of the literature. | we report here 3 cases of aspergillus sinusitis in patients with aids and the 1st fully described case, to our knowledge, of sinusitis associated with pseudallescheria boydii in a patient with aids. we review the microbiology and pathology of fungal sinusitis in patients with aids and the morphologic and clinical features and treatment of p. boydii infection and aspergillus sinusitis. fungal sinusitis in patients with hiv or aids generally occurs later in the course of primary disease with low c ... | 1994 | 8152366 |
| successful bone marrow transplantation in patients with previous invasive fungal infections: report of four cases. | patients with previous invasive fungal infections (ifi) are at high risk of reactivation of the infection during bmt, even after an apparently curative antifungal treatment. we report four patients who suffered an ifi after intensive chemotherapy for acute leukemia and were later submitted for bmt. one patient had developed a chronic systemic candidiasis during consolidation chemotherapy and received prophylactic oral or iv fluconazole (200 mg daily) throughout bmt. two patients developed an inv ... | 1994 | 8199569 |
| fungal corneoscleritis complicating beta-irradiation-induced scleral necrosis following pterygium excision. | four cases of fungal corneoscleritis complicating beta-irradiation-induced scleral necrosis after pterygium excision have presented to our institution in recent years. two cases were due to petriellidium boydii and one each to fusarium and scedosporium inflatum. the condition may remain undiagnosed for weeks to months and becomes chronic with perforation or incipient perforation. the infections may masquerade as a chronic red eye, posterior scleritis or serous retinal detachment. penetrating or ... | 1993 | 8253231 |
| [disseminated infection due to scedosporium apiospermum in liver transplantation. differential diagnosis from invasive aspergillosis]. | a case of fatal disseminated infection due to scedosporium apiospermum occurring after liver transplantation is reported. diagnosis was made at autopsy, as numerous fungal colonies were found in the lungs, heart, brain, kidney, spleen and liver. scedosporium apiospermum was identified in pulmonary, cerebral and myocardial specimens by sabouraud's glucose agar cultures. infections due to scedosporium (s. apiospermum ou pseudallescheria boydii) occur in immunocompromised hosts, particularly after ... | 1993 | 8311860 |
| isolated sphenoid sinusitis due to pseudallescheria boydii. | a case of sphenoid sinusitis due to pseudallescheria boydii is described in a 52-year-old non-immunocompromised woman. treatment should always involve surgical drainage, and antifungal chemotherapy may be of benefit if there is histological evidence of invasion of surrounding tissue. for p. boydii infection miconazole should be the agent of choice, rather than amphotericin b. for this reason it is important to obtain culture and histological examination of sinus contents if fungal infection is s ... | 1993 | 8320525 |
| severe corneoscleral infection. a complication of beta irradiation scleral necrosis following pterygium excision. | to assess the precipitating factors, clinical course, and treatment of 11 cases of severe intraocular infections of radionecrosis after pterygium excision in an attempt to minimize the devastating ocular sequelae. | 1993 | 8328937 |
| allergic bronchopulmonary mycosis caused by pseudallescheria boydii. | two cases of allergic bronchopulmonary pseudallescheriosis (abpp) are described. these are the first cases of this allergic bronchopulmonary mycosis (abpm) reported in which the clinical and serologic criteria are described. the first case was in a patient with mild asthma, and it resolved spontaneously after expectoration of a mucous plug. the second was in a patient with recurrent allergic bronchopulmonary aspergillosis with an exacerbation of abpm caused by pseudallescheria boydii. the total ... | 1993 | 8368653 |
| successful treatment of simultaneous pulmonary pseudallescheria boydii and aspergillus terreus infection with oral itraconazole. | pseudallescheria boydii and aspergillus terreus are unusual opportunistic fungal pathogens that are often resistant to chemotherapy with amphotericin b. we report a case of simultaneous invasive pulmonary infection with these organisms occurring in a bone marrow transplant recipient who was successfully treated with the oral azole itraconazole. | 1993 | 8392389 |
| osteomyelitis due to pseudallescheria boydii. | this report describes an unusual opportunistic fungal infection in an immunocompetent young man who had no cutaneous involvement and whose infection was diagnosed 6 years after an accident. the unusual clinical presentation and difficulties in making a correct diagnosis are discussed and prophylactic antifungal chemotherapy is suggested. | 1993 | 8434301 |
| recurrent pseudallescheria boydii sinusitis in acute leukemia. | most episodes of fungal sinusitis in immunocompromised patients are caused by aspergillus species. to treat such infections, surgical debridement and anti-fungal therapy have been recommended; it is also clear however that an adequate neutrophil count is important in controlling such infections. we report a case in which fungal sinusitis was shown to be due to p. boydii and in which the infection recurred over a period of 2 years during episodes of neutropenia in spite of vigorous surgical and m ... | 1993 | 8511522 |
| arthritis without grains caused by pseudallescheria boydii. | severe infection of the knee joint by pseudallescheria boydii in a 23-year-old female resulted in complete destruction of the cartilaginous surface. the possibility of entry of the fungus through mild abrasions of unperforated skin is discussed. the clinical appearance is compared with that of scedosporium prolificans. antimycotic miconazole-itraconazole treatment, applied during a period of 4 months, was successful; no side-effects were noted. | 1995 | 8569811 |
| molecular probes for diagnosis of fungal infections. | we have developed 21 specific nucleic acid probes which target the large subunit rrna genes from aspergillus flavus, aspergillus fumigatus, aspergillus glaucus, aspergillus niger, aspergillus terreus, blastomyces dermatitidis, candida albicans, candida (torulopsis) glabrata, candida guilliermondii, candida kefyr, candida krusei, candida lusitaniae, candida parapsilosis, candida tropicalis, coccidioides immitis, cryptococcus neoformans var. gattii, cryptococcus neoformans var. neoformans, filobas ... | 1995 | 8576345 |
| pcr and single-strand conformational polymorphism for recognition of medically important opportunistic fungi. | the application of pcr technology to molecular diagnostics holds great promise for the early identification of medically important pathogens. pcr has been shown to be useful for the detection of the presence of fungal dna in both laboratory and clinical samples. considerable interest has been focused on the utility of selecting universal primers, those that recognize constant regions among most, if not all, medically important fungi. once an amplicon, or piece of amplified dna determined by the ... | 1995 | 8586705 |
| pseudallescheria boydii in an immunocompromised host. successful treatment with debridement and itraconazole. | 1996 | 8629840 | |
| cerebral pseudallescheria mycosis after near-drowning. | scedosporium apiospermum, an anamorph of pseudallescheria boydii, is a hyalohyphomycete which can be mistaken, histologically, for aspergillus. s. apiospermum is clinically distinguished by resistance to most antifungals and its ability to cause invasive mycoses in immunocompetent patients. here we present a typical case of lethal cerebral pseudallescheria mycosis in a child after near-drowning. | 1995 | 8720198 |
| fluconazole in the therapy of tropical deep mycoses. | a clinical study was conducted to test the efficacy of fluconazole in the treatment of tropical deep mycoses. two out of four patients with zygomycosis due to conidiobolus coronatus who were treated with the drug were completely cured; the other two patients exhibited considerable improvement but could not be followed up. two patients with eumycetoma, one due to an acremonium sp. and one due to pseudallescheria boydii, were treated successfully, whereas another patient with a eumycetoma caused b ... | 1995 | 8720201 |
| pseudo-allescheria boydii endophthalmitis. | 1996 | 8789871 | |
| fatal pseudallescheria boydii panencephalitis in a child after near-drowning. | 1996 | 8866809 | |
| scedosporium apiospermum pneumonia after autologous bone marrow transplantation. | although opportunistic infections after bone marrow transplantation (bmt) are very common, only five cases of pseudallescheria boydii infection have been reported in the literature, two of which were autopsy findings. a case of scedosporium apiospermum infection after bmt, treated initially with amphotericin b (total dose of 2.5 g) and then with itraconazole (for 25 days), is reported here. when the patient failed to improve, scedosporium apiospermum pneumonia was diagnosed and therapy was chang ... | 1996 | 8874080 |
| pseudallescheria boydii infection of the brain: imaging with pathologic confirmation. | pseudallescheria boydii is a rare opportunistic microorganism that usually infects immunosuppressed hosts. in this patient with cerebral infection by p boydii, imaging findings included enhancement of the ependyma of a lateral ventricle and of the caudate nucleus. | 1996 | 8881260 |
| immunoperoxidase staining for identification of aspergillus species in routinely processed tissue sections. | to evaluate the performance of an immunoperoxidase stain using the monoclonal antibody eb-a1 to detect aspergillus species in formalin fixed, paraffin wax embedded tissue. | 1996 | 8943743 |
| multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi. | a multicenter study was conducted to expand the generation and analysis of data that supports the proposal of a reference method for the antifungal susceptibility testing of filamentous fungi. broth microdilution mics of amphotericin b and itraconazole were determined in 11 centers against 30 coded duplicate pairs of aspergillus spp., fusarium spp., pseudallescheria boydii, and rhizopus arrhizus. the effect of inoculum density (approximately 10(3) and 10(4) cfu/ml), incubation time (24, 48, and ... | 1997 | 8968895 |
| pulmonary tuberculosis associated with invasive pseudallescheriasis. | a 54-year-old woman with pulmonary tuberculosis developed pneumonia caused by scedosporium apiospermum, the asexual stage of the fungus pseudallescheria boydii. mycobacterium tuberculosis and p boydii were cultured in bal fluid. the patient cleaned swimming pools in a spa health resort and was highly exposed to fungal conidia. she was successfully treated with antituberculosis drugs, miconazole nitrate and ketoconazole, leading to remission of her pulmonary infection. invasive pulmonary pseudall ... | 1997 | 9042007 |
| oral terbinafine for treatment of pulmonary pseudallescheria boydii infection refractory to itraconazole therapy. | 1997 | 9063671 | |
| vertebral osteomyelitis due to pseudallescheria boydii. | a case of primary vertebral osteomyelitis due to an opportunistic fungus, pseudallescheria boydii, in a child with acute myeloid leukemia, is reported. to our knowledge this is the first such case in a child, and only the second reported case in the international literature of primary spinal osteomyelitis due to this organism. we discuss the problems presented by this case both in terms of diagnosis and management. we also discuss the role of surgery and systemic antifungal chemotherapy in the t ... | 1997 | 9213351 |
| risk of reactivation of a recent invasive fungal infection in patients with hematological malignancies undergoing further intensive chemo-radiotherapy. a single-center experience and review of the literature. | patients with hematologic malignancies and a history of an invasive fungal infection are considered to be at high risk of suffering reactivation of the infection during subsequent intensive chemotherapy. | 1997 | 9234575 |
| infectious posterior scleritis caused by pseudallescheria boydii. clinicopathologic findings. | the purpose of the study is to describe an unusual case of infectious posterior scleritis after excision of a pterygium. | 1997 | 9261319 |
| immunohistologic identification of aspergillus spp. and other hyaline fungi by using polyclonal fluorescent antibodies. | isolation and identification of pathogenic aspergillus and fusarium spp. from clinical materials provide the most accurate means for establishing a diagnosis of infections by these molds. such efforts, however, are not always successful. histologic diagnosis also has its limitations. in vivo the hyphae of aspergillus and fusarium spp. are very similar and their in situ manifestations are not pathognomonic. to improve the histologic diagnosis of infections by aspergillus and fusarium species, we ... | 1997 | 9276388 |
| sulconazole in the therapy of dermatomycoses in nigeria. | a 1% cream of sulconazole nitrate, an imidazole derivative, was used to treat 38 patients with diverse clinical types of dermatomycoses, including 16 cases of pityriasis versicolor, 14 of dermatophytosis (tinea pedis, tinea cruris, tinea corporis), two of balanoposthitis due to candida albicans, another two of candidosis of the groin, one each of groin and foot infection due to trichosporon beigelii and one case each of lesions of the hand and trunk caused by petriellidium boydii and scytalidium ... | 1997 | 9375503 |
| invasive pseudallescheria boydii fungal infection of the temporal bone. | 1997 | 9419113 | |
| in vitro activity of the new triazole voriconazole (uk-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens. | the in vitro antifungal activity of a new triazole derivative, voriconazole, was compared with those of itraconazole and amphotericin b against 67 isolates of aspergillus flavus, aspergillus fumigatus, bipolaris spp., fusarium oxysporum, fusarium solani, pseudallescheria boydii, rhizopus arrhizus, blastomyces dermatitidis, histoplasma capsulatum, and sporothrix schenckii. the in vitro activities of voriconazole were also compared with those of amphotericin b, fluconazole, and itraconazole agains ... | 1998 | 9431946 |
| evaluation of possible correlations between antifungal susceptibilities of filamentous fungi in vitro and antifungal treatment outcomes in animal infection models. | nine isolates of filamentous fungi previously tested in 11 different laboratories for their susceptibilities to amphotericin b and itraconazole in vitro were injected intravenously into mice and guinea pigs, and responses to treatment with both agents were studied. the experiments were done in a single laboratory. mean survival times, the percentages of animals surviving 12 days after infection, and culture results for samples of deep organs obtained postmortem were used as markers of antifungal ... | 1998 | 9527773 |
| in vitro activity of a new oral triazole, bms-207147 (er-30346) | the antifungal activity of bms-207147 (also known as er-30346) was compared to those of itraconazole and fluconazole against 250 strains of fungi representing 44 fungal species. mics were determined by using the national committee for clinical laboratory standards (nccls)-recommended broth macrodilution method for yeasts, which was modified for filamentous fungi. bms-207147 was about two- to fourfold more potent than itraconazole and about 40-fold more active than fluconazole against yeasts. wit ... | 1998 | 9527778 |
| scedosporium apiospermum (pseudallescheria boydii) infection in a heart transplant recipient: a case of mistaken identity. | we report a case of fatal central nervous system infection with scedosporium apiospermum (pseudallescheria boydii) in a heart transplant recipient. this ubiquitous fungus is known to cause mycetoma and localized infections in patients with otherwise normal conditions. disseminated infections occur rarely and are seen primarily in patients who are receiving immunosuppressive medications or who have neutropenia. often life-threatening when infection is disseminated and involves the central nervous ... | 1998 | 9563611 |
| in vitro activity of two echinocandin derivatives, ly303366 and mk-0991 (l-743,792), against clinical isolates of aspergillus, fusarium, rhizopus, and other filamentous fungi. | ly303366 and mk-0991 (previously l-743,792) are new echinocandin derivatives with excellent broad-spectrum antifungal activity. we investigated the in vitro activity of ly303366, mk-0991, itraconazole, amnphotericin b, and 5-flucytosine against 51 clinical isolates of filamentous fungi, including aspergillus flavus (10), a. fumigatus (12), fusarium spp. (13), rhizopus spp. (6), pseudallescheria boydii (5), and one isolate each of acremonium spp., a. niger, a terreus, paecilomyces spp., and trich ... | 1998 | 9582584 |
| degradation of hydrocarbons in crude oil by the ascomycete pseudallescheria boydii (microascaceae). | four unique strains of pseudallescheria boydii were isolated from oil-soaked soils in british columbia and alberta and compared to strains from cattle dung and raw sewage. considerable variability in morphology, colony appearance, colony diameter, and temperature tolerance occurred among the strains. they also varied in the sporogenous states produced in culture; all strains had a scedosporium anamorph and either the graphium anamorph or cleistothecial teleomorph. conspecificity of the six isola ... | 1998 | 9606909 |
| rapid extraction of genomic dna from medically important yeasts and filamentous fungi by high-speed cell disruption. | current methods of dna extraction from different fungal pathogens are often time-consuming and require the use of toxic chemicals. dna isolation from some fungal organisms is difficult due to cell walls or capsules that are not readily susceptible to lysis. we therefore investigated a new and rapid dna isolation method using high-speed cell disruption (hscd) incorporating chaotropic reagents and lysing matrices in comparison to standard phenol-chloroform (pc) extraction protocols for isolation o ... | 1998 | 9620390 |
| cerebral pseudallescheriasis due to pseudallescheria boydii as the first manifestation of aids. | 1998 | 9636891 | |
| comparison of in vitro activities of the new triazole sch56592 and the echinocandins mk-0991 (l-743,872) and ly303366 against opportunistic filamentous and dimorphic fungi and yeasts. | the in vitro antifungal activities of sch56592, mk-0991, and ly303366 against 83 isolates of acremonium strictum, aspergillus flavus, aspergillus fumigatus, aspergillus terreus, bipolaris spp., blastomyces dermatitidis, cladophialophora bantiana, fusarium oxysporum, fusarium solani, histoplasma capsulatum, phialophora spp., pseudallescheria boydii, rhizopus arrhizus, scedosporium prolificans, and sporothrix schenckii were compared. the in vitro activities of these agents against 104 isolates of ... | 1998 | 9738049 |
| [pulmonary pseudallescheriasis in a patient with diabetes mellitus and alcoholic liver cirrhosis]. | a 62-year-old man with diabetes mellitus and alcoholic liver cirrhosis was admitted to the hospital because of hemoptysis. chest x-ray films and computed tomograms showed a dense infiltrative lesion and a healed tuberculous cavity with a possible fungus ball in the upper lobe of the right lung. bronchoscopy revealed that the hemoptysis originated from the right upper-lobe bronchus. the bleeding stopped after thrombin was applied into the bronchus. filamentous fungi were seen in lavage fluid from ... | 1998 | 9742872 |
| in vitro activity of a new triazole antifungal agent, sch 56592, against clinical isolates of filamentous fungi. | sch 56592 is a new triazole derivative that possesses potent, broad-spectrum antifungal activity. we evaluated the in vitro activity of sch 56592 compared with that of itraconazole, amphotericin b and 5-fluorocytosine against 51 clinical isolates of filamentous fungi, including aspergillus flavus (10), a. fumigatus (12), fusarium spp. (13), rhizopus spp. (6), pseudallescheria boydii (5), and one isolate each of acremonium spp., a. niger, a. terreus, paecilomyces spp., and trichoderma spp. in vit ... | 1998 | 9750338 |
| pcr-based identification of clinically relevant pseudallescheria/scedosporium strains. | pseudallescheria boydii (anamorph: scedosporium apiospermum) and s. prolificans can cause severe infections in both the immunocompromized host and accidentally injured people. a species-specific polymerase chain reaction (pcr) enabling detection and discrimination of these fungi has not been available to date. in view of the difficult treatment especially of s. prolificans infections, a pcr-based detection system has been developed. based on results of partial sequencing of ribosomal dna, scedos ... | 1998 | 9776815 |
| sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, pneumocystis carinii, and filamentous fungi. | gm 193663, gm 211676, gm 222712, and gm 237354 are new semisynthetic derivatives of the sordarin class. the in vitro antifungal activities of gm 193663, gm 211676, gm 222712, and gm 237354 against 111 clinical yeast isolates of candida albicans, candida kefyr, candida glabrata, candida parapsilosis, candida krusei, and cryptococcus neoformans were compared. the in vitro activities of some of these compounds against pneumocystis carinii, 20 isolates each of aspergillus fumigatus and aspergillus f ... | 1998 | 9797217 |
| pathology of hyalohyphomycosis caused by scedosporium apiospermum (pseudallescheria boydii): an emerging mycosis. | the genus scedosporium contains two medically significant species of emerging mycotic agents, s. apiospermum and s. prolificans, which have received scant attention. scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus pseudallescheria boydii, with both sharing the same risk factors for infection, clinical spectrum, and histopathologic features. scedosporium prolificans is a recently recognized agent of bone, soft tissue, and joint infections that occurs with hi ... | 1998 | 9824105 |
| [cutaneous scedosporium infection revealed by bullous-necrotic purpura]. | non-mycetomatous cutaneous scedosprium is an uncommon mycosis observed in immunodepressed subjects. we report a case with an inaugural presentation of bullous and necrotic purpura. | 1998 | 9835962 |
| pulmonary scedosporiosis. | a case of a solitary pulmonary nodule due to scedosporium apiospermum (pseudallescheria boydii) is related. a review of the pertinent literature was done and, in addition, similar lesions caused by other opportunistic fungi are commented. | 1998 | 9876438 |
| onychomycosis in white line disease in horses: pathology, mycology and clinical features. | this paper describes onychomycosis in horses and reports the pathological findings, associated fungi and incidence of concurrent white line disease. in addition to these observations, relevance between post mortem and clinical findings of onychomycosis are discussed in 3 necropsied horses. samples were collected from 100 hooves from a total of 51 thoroughbreds suffering from white line disease. of these, 15 hooves from 13 horses were also complicated with severe hoof wall fissure formation. prep ... | 1998 | 9932091 |
| pulmonary pseudallescherioma associated with systemic lupus erythematosus. | we report a case of fungus ball due to pseudallescheria boydii (pseudallescherioma) associated with systemic lupus erythematosus. direct microscopical examination revealed a fungus with broad septate hyphae resembling aspergillus and the fungus was identified as p. boydii on culture. surgical resection was required to control episodes of hemoptysis. cases of pulmonary pseudallescheriasis are rare, especially in japan. however, some cases previously diagnosed as pulmonary aspergillosis may have b ... | 1998 | 9932639 |
| pseudallescheria boydii infection in aids. | 1999 | 10048912 | |
| [fungal flora in chicken stalls and its etiopathogenic importance for humans and animals]. | in order to find out the mycoflora prevailing in chicken pens, and to appreciate the health hazards for employees (incl. veterinarians) and animals, twenty litter samples and 6 sedimented dust trials were analysed mycologically. the following results were found: bedding and dust samples all contained between 3.57 and 1.30 x 10(7) c.f.u./g dw. the commonest fungus is a. fumigatus with 3.41 x 10(4) - 1.30 x 10(7) c.f.u./g dw in bedding and 2.70 x 10(5) - 3.30 x 10(6) c.f.u./g dw in sedimented dust ... | 1999 | 10209909 |
| the influence of bacterial inoculants on the microbial ecology of aerobic spoilage of barley silage. | the aerobic decomposition of barley silage treated with two inoculants (laca and lacb) containing mixtures of lactobacillus plantarum and enterococcus faecium was investigated over a 28-day period. initially, yeast and bacterial populations were larger in silage inoculated with laca than in silage treated with lacb or water alone (control). differences in the succession of yeasts in silage treated with laca were observed relative to the other two treatments. from silage treatment with laca, issa ... | 1999 | 10349723 |
| [pseudallescheria boydii osteoarthritis in a patient with acute lymphoblastic leukemia: a case report]. | the outcome of neutropenic patients with pseudallescheria boydii infection is poor. | 1999 | 10365416 |
| radioiodine uptake in inactive pulmonary tuberculosis. | radioiodine may accumulate at sites of inflammation or infection. we have seen such accumulation in six thyroid cancer patients with a history of previously treated pulmonary tuberculosis. we also review the causes of false-positive radioiodine uptake in lung infection/inflammation. eight foci of radioiodine uptake were seen on six iodine-123 diagnostic scans. in three foci, the uptake was focal and indistinguishable from thyroid cancer pulmonary metastases from thyroid cancer. in the remaining ... | 1999 | 10369953 |
| fatal native valve endocarditis due to scedosporium apiospermum (pseudallescheria boydii) following trauma. | 1999 | 10421053 | |
| disseminated pseudallescheria boydii infection in a nonimmunocompromised host. | we present a highly unusual case of pulmonary pseudallescheria boydii infection in a nonimmunocompromised host with a cavitating mass lesion. the diagnosis was confirmed by open lung biopsy. the patient was treated at another institution with course of amphotericin b, considered an ineffective therapy for this infection, and presented to us with direct extension and invasion of the left atrial appendage and the pulmonary artery, followed by massive pulmonary embolization and hematogenous dissemi ... | 1999 | 10453893 |
| successful treatment of madura foot caused by pseudallescheria boydii with escherichia coli superinfection: a case report. | 1999 | 10459334 | |
| electrotransformation of the human pathogenic fungus scedosporium prolificans mediated by repetitive rdna sequences. | the regions encoding the 5.8s rrna and the flanking internal transcribed spacers (itsi and itsii) from two isolates of the human pathogenic fungus scedosporium prolificans and one isolate of the taxonomically related species pseudallescheria boydii (s. apiospermum) were sequenced. the sequences of the two s. prolificans isolates were identical. however, there were minor differences between both species. phylogenetic analysis of known fungal sequences confirmed a close relationship between s. pro ... | 1999 | 10459582 |
| case report. atypical cutaneous pseudallescheriosis refractory to antifungal agents. | we report on a 65-year-old male heart transplant recipient who was otherwise in good condition. the patient was immunocompromised secondarily due to cyclosporin, prednisolone and azathioprine when widespread pustular skin lesions with erythematous margins subsequently developed on his left forearm. there was no history of trauma or septic temperature. bacterial cultures were sterile and the results of native and cultural investigation studies were negative. a biopsy specimen of the lesion demons ... | 1999 | 10546493 |
| fungal susceptibility testing. | the utility of antifungal susceptibility testing has not been broadly determined. thus, susceptibility testing of fungal isolates is not recommended on a routine basis. for instance, susceptibilty testing may be considered for some candida species and for patients with pseudallescheria boydii infections. testing of yeasts for susceptiblity to azoles is of particular value due to their variability in response to these agents. it may also be important to test the susceptibility of new fungal organ ... | 1999 | 10571444 |
| in-situ detection of aspergillus fumigatus. | an in-situ hybridisation (ish) technique to detect aspergillus fumigatus in infected tissues was developed in which 568-bp, 333-bp and 154-bp pcr products of the alkaline proteinase gene were employed. dot-blot hybridisation with the 568-bp probe on a membrane containing genomic dna from several different fungi including a. flavus, a. niger, penicillium spp., mucor racemosus or pseudallescheria boydii gave negative results. ish was done on formalin-fixed, paraffin-embedded pulmonary tissues from ... | 2000 | 10707949 |
| antifungal activity of the new azole uk-109, 496 (voriconazole). | the in vitro activity of voriconazole fully includes aspergillus, and also emerging moulds like fusarium, pseudallescheria boydii, and penicillium marneffei. the minimal inhibitory concentrations of voriconazole for candida krusei and candida glabrata, which are resistant or less susceptible to fluconazole, promise clinical efficacy, although they are ten times higher (0.30-0.39 microgram/ml) than those for candida albicans and other candida spp. (0.001-0.05 microgram/ml). the endemic fungal pat ... | 1999 | 10865910 |
| activity of terbinafine against serious fungal pathogens. | although primarily indicated for dermatophyte infections, the allylamine terbinafine is active in vitro against a broad spectrum of filamentous and dimorphic fungi, in most cases with a primary fungicidal action. using the standard nccls m27-a assay, recent studies confirmed the high activity of terbinafine against dematiaceous fungi and other medically important moulds such as aspergillus and penicillium marneffei. terbinafine displayed a geometric mean mic of 1.4 micrograms/ml against candida ... | 1999 | 10865917 |
| meningitis caused by pseudallescheria boydii treated with voriconazole. | meningitis caused by pseudallescheria boydii is an uncommon infection of the cns that usually has a poor prognosis and a difficult treatment. we describe a case of chronic meningitis caused by p. boydii in an immunocompetent host that was successfully treated with voriconazole, a new antifungal agent. | 2000 | 10880322 |
| unusual presentations of isolated sphenoid fungal sinusitis. | isolated sphenoid fungal sinusitis is a rare and often difficult to diagnose condition as the presenting symptoms are often vague and non-specific. in this series each case has a different clinical presentation with a different causative fungus. although isolated fungal sphenoid sinusitis is usually seen in immunocompromised individuals, two of the three cases presented were immunocompetent. the fungi were pseudallescheria boydii, aspergillus fumigatus and schizophyllum commune. in order to illu ... | 2000 | 10912273 |
| molecular variability of pseudallescheria boydii, a neurotropic opportunist. | the sequences of the internal transcribed spacer (its) ribosomal dna (rdna) domain data obtained by restriction fragment length polymorphism analysis with 18s rdna and fingerprinting (m13) for clinical and environmental strains of pseudallescheria boydii (anamorph, scedosporium apiospermum) were compared to those for related species of pseudallescheria, petriella, and scedosporium. the infraspecific variability of p. boydii was considerable. there were five different lengths in the 18s rdnas wit ... | 2000 | 10970369 |
| in vitro susceptibility testing of filamentous fungi: comparison of etest and reference microdilution methods for determining itraconazole mics. | the performance of the etest for itraconazole susceptibility testing of 50 isolates of filamentous fungi was assessed in comparison with the national committee for clinical laboratory standards (nccls) proposed standard microdilution broth method. the nccls method employed rpmi 1640 broth medium, and mics were read after incubation for 48 h at 35 degrees c. etest mics were determined with rpmi agar containing 2% glucose and with casitone agar and were read after incubation for 24 h (aspergillus ... | 2000 | 10970383 |
| pseudallescheria boydii infection of the nasal cavity of a horse. | an 18-year-old 454-kg (1,000-lb) american quarter horse gelding was evaluated because of chronic intermittent malodorous right-sided nasal discharge. endoscopy revealed a mycotic plaque in the nasal cavity adjacent to the nasomaxillary opening of the right caudal maxillary sinus. the nasomaxillary opening appeared to be larger than normal. fungal culture of specimens of the mycotic plaque yielded pseudallescheria boydii. the horse was treated with 2% miconazole intranasally, sodium iodide i.v., ... | 2000 | 10976304 |
| pseudallescheria boydii brain abscess successfully treated with voriconazole and surgical drainage: case report and literature review of central nervous system pseudallescheriasis. | pseudallescheria boydii and its asexual form, scedosporium apiospermum, are ubiquitous, saprophytic fungi that commonly cause cutaneous infection. however, in certain circumstances, p. boydii can also cause invasive disease, which can involve the central nervous system (cns). when the cns becomes involved, treatment is difficult, therapeutic options are limited, and the prognosis is poor. we report a case of pseudallescheria brain abscess successfully treated with surgical drainage and systemic ... | 2000 | 11017814 |
| [new developments in therapy of deep mycoses]. | over the past two decades the incidence of deep mycoses caused by several major groups of fungal pathogens such as candida spp., aspergilli, cryptococcus neoformans and zygomycetes has risen steadily. moreover, opportunistic fungal infections due to fusarium spp., trichosporon spp., pseudallescheria boydii and other emerging pathogens, as well as fluconazole-resistant candida albicans, all of which are often resistant to existing antifungal drugs, are also encountered more and more frequently. t ... | 2000 | 11064319 |
| fungal keratitis caused by pseudallescheria boydii (scedosporium apiospermum). | keratitis is rarely caused by fungi. filamentous fungal keratitis is often preceded by corneal trauma and occurs mostly in previously healthy individuals. we studied a case of posttraumatic keratitis caused by pseudallescheria boydii, which belongs to the group of filamentous fungi. | 2000 | 11126674 |
| mycoflora and mycotoxins in brazilian black pepper, white pepper and brazil nuts. | a wide range of field and storage fungi were isolated from black pepper, white pepper and brazil nut kernels from amazonia. a total of 42 species were isolated from both peppers. aspergillus flavus and a. niger were isolated more frequently from black than from white pepper. other potential mycotoxigenic species isolated included: a. ochraceus, a. tamarii, a. versicolor, emericella nidulans and chaetomium globosum, penicillium brevicompactum, p. citrinum, p. islandicum and p. glabrum. species is ... | 2000 | 11229375 |
| a peptidorhamnomannan from the mycelium of pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen. | the ascomycete pseudallescheria boydii is an emerging human pathogen frequently found in soil and polluted water. a peptidopolysaccharide antigen has been isolated from mycelial forms of p. boydii, and characterized using chemical and immunological methods. monosaccharide composition, methylation analysis, and (1)h- and (13)c-nmr spectra indicated the presence of a rhamnomannan with a structure distinct from those of similar components isolated from other fungi, containing rhap(1-->3)rhap epitop ... | 2001 | 11390680 |
| emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty-first century. | opportunistic fungi have emerged during the past decade as important causes of morbidity and mortality in immunocompromised patients. candida species constitute the third to fourth most common causes of nosocomial blood stream infections, and aspergillus species have emerged as the most common infectious cause of pneumonic mortality in bone marrow/stem cell transplant recipients. among hiv-infected patients, meningoencephalitis due to cryptococcus neoformans ranks among the most common aids-defi ... | 1999 | 11428996 |
| endogenous pseudallescheria boydii endophthalmitis in a patient with ring-enhancing brain lesions. | a 46-year-old man, status post liver transplantation and taking immunosuppressive medications, was admitted after suffering a generalized seizure. magnetic resonance imaging of the brain revealed two ring-enhancing lesions and treatment was begun for presumed toxoplasmic encephalitis. he was already receiving amphotericin b for a skin lesion suspected to be caused by candidiasis. one day after the seizure, he complained of photophobia in the left eye. intraocular inflammation and a small infiltr ... | 2001 | 11475400 |
| vertebral osteomyelitis secondary to pseudallescheria boydii. | because pseudallescheria boydii vertebral osteomyelitis is rare and frequently resistant to available antifungal agents, the proper treatment of this lesion has not been defined. to better determine the best treatment of this lesion, the authors evaluated a case p. boydii vertebral osteomyelitis and reviewed the literature. a 48-year-old man had isolated thoracic vertebral osteomyelitis resulting from p. boydii and associated severe thoracic back pain and proximal lower extremity pain and weakne ... | 2001 | 11481561 |
| systemic antifungal agents. | anti-fungal agents are classified under two major headings, systematic and topical agents. only systematic anti-fungal agents will be discussed in this chapter. since the discovery in 1955, amphotericin b has been the cornerstone of anti-fungal treatment. it is active against most species of fungi. however, candida lusitaniae, pseudallescheria boydii, and fusarium spp have primary resistance to amphotericin b. recently, new liposomal preparations of amphotericin b have been developed. they are l ... | 2001 | 11519290 |
| uncommon opportunistic fungi: new nosocomial threats. | during the past two decades opportunistic fungal infections have emerged as important causes of morbidity and mortality in patients with severe underlying illnesses and compromised host defenses. while aspergillus and candida spp. collectively account for the majority of these infections, recent epidemiological trends indicate a shift towards infections by aspergillus spp., nonalbicans candida spp., as well as previously uncommon opportunistic fungi. apart from an expanding number of different z ... | 2001 | 11525222 |
| atypical skin lesions caused by curvularia sp. and pseudallescheria boydii in two patients after allogeneic bone marrow transplantation. | we report two patients who developed atypical skin lesions caused by curvularia sp. and pseudallescheria boydii after allogeneic bone marrow transplantation for severe aplastic anemia. the first patient (female, 18-year-old) had multiple hemorrhagic vesicles on day +30 after her second bmt for graft failure. pseudallescheria boydii was isolated from a skin biopsy. the patient died of respiratory failure probably as a consequence of systemic fungal infection. the second patient (male, 9-year-old) ... | 2001 | 11548851 |
| typing of scedosporium apiospermum by multilocus enzyme electrophoresis and random amplification of polymorphic dna. | the genetic diversity among epidemiologically unrelated strains of the human pathogenic fungus scedosporium apiospermum or its teleomorph, pseudallescheria boydii, from different areas in europe, was investigated by multilocus enzyme electrophoresis (mlee) and random amplification of polymorphic dna (rapd). fourteen enzyme activities were analysed by starch gel electrophoresis, corresponding to 27 polymorphic loci and 43 iso-enzymes. among the enzymes studied, propionate esterase, carboxyl ester ... | 2001 | 11599744 |
| pseudallescheria boydii knee arthritis in a young immunocompetent adult two years after a compound patellar fracture. | pseudallescheria boydii arthritis of the knee developed in a 32-year-old immunocompetent man 2 years after a compound patellar fracture contaminated with soil. no other potential portal of entry was identified, suggesting that the fungus remained latent for 2 years. pseudallescheria arthritis often occurs after a prolonged latency period, causing minimal symptoms that contrast with the frequently severe radiological changes. although this organism often shows limited sensitivity to most antifung ... | 2001 | 11808991 |
| fungal skin infections in organ transplant recipients. | transplantation is now currently and increasingly performed for the treatment of various acute and chronic diseases. today the kidney, heart, lung, heart-lung, liver, pancreas, kidney-pancreas, small bowel and bone marrow are being transplanted. the immunological status of patients receiving such transplants exposes them to the risk of developing bacterial, viral and fungal infections. the etiological agents of mycotic diseases involving the skin of transplant recipients range from the common de ... | 2002 | 11817966 |
| central nervous system aspergillosis: a 20-year retrospective series. | over the past 20 years at my institution, 71 patients with invasive necrotizing aspergillosis have been encountered; 42 have shown central nervous system (cns) involvement by autopsy (40) or surgical biopsy (2). most non-cns aspergillosis patients had invasive disease confined to the lung, and only 2 with dissemination to 3 or more organs did not have spread to the cns. in addition to the expected post-transplantation and hematologic malignancy cases, other risk groups identified included those ... | 2002 | 11823982 |
| pseudallescheriasis as an aggressive opportunistic infection in a bone marrow transplant recipient. | pseudallescheria boydii is a low-virulence fungus that is the main causative agent of posttraumatic mycetoma in a nonimmunocompromised host. immunocompromised patients are at high risk for locally invasive or disseminated pseudallescheria infection. however, aggressive opportunistic infections due to p boydii are reported infrequently because it morphologically resembles other fungi, especially aspergillus species, on tissue histology; therefore, such infections are not identified and treated pr ... | 2002 | 11825121 |
| cutaneous infection showing sporotrichoid spread caused by pseudallescheria boydii (scedosporium apiospermum): successful detection of fungal dna in formalin-fixed, paraffin-embedded sections by seminested pcr. | 2002 | 11843660 | |
| pulmonary scedosporium infection following lung transplantation. | infectious complications are frequent following lung transplantation. tracheobronchial aspergillosis is the predominant fungal infection in these patients. infections with scedosporium apiospermium (pseudoallescheria boydii) and scedosporium prolificans (scedosporium inflatum) have mainly been described in bone marrow transplant recipients and only occasionally in solid organ transplant recipients. we analysed risk factors, the clinical course and outcome of seven lung transplant recipients who ... | 2001 | 11844150 |
| a chemically modified tetracycline (cmt-3) is a new antifungal agent. | several chemically modified tetracycline analogs (cmts), which were chemically modified to eliminate their antibacterial efficacy, were unexpectedly found to have antifungal properties. of 10 cmts screened in vitro, all exhibited antifungal activities, although their efficacies varied. among these compounds, cmt-315, -3, and -308 were found to be the most potent as antifungal agents. the mics of cmt-3 against 47 strains of fungi in vitro were determined by using amphotericin b (amb) and doxycycl ... | 2002 | 11959581 |
| scedosporium apiospermum fungemia in a lung transplant recipient. | scedosporium apiospermum, the asexual anamorph of the cosmopolitan fungus pseudallescheria boydii, is emerging as an important cause of disseminated infection in immunocompromised patients. we present our experience with the first reported case of s apiospermum fungemia in a lung transplant patient. disseminated infection resulted in sepsis, multiorgan failure, and death. review of the literature highlights the diagnostic difficulties related to the similarities between s. apiospermum and asperg ... | 2002 | 12006471 |