| pathology of hyalohyphomycosis caused by scedosporium apiospermum (pseudallescheria boydii): an emerging mycosis. | the genus scedosporium contains two medically significant species of emerging mycotic agents, s. apiospermum and s. prolificans, which have received scant attention. scedosporium apiospermum is the anamorph, or asexual state, of the cosmopolitan fungus pseudallescheria boydii, with both sharing the same risk factors for infection, clinical spectrum, and histopathologic features. scedosporium prolificans is a recently recognized agent of bone, soft tissue, and joint infections that occurs with hi ... | 1998 | 9824105 |
| [cutaneous scedosporium infection revealed by bullous-necrotic purpura]. | non-mycetomatous cutaneous scedosprium is an uncommon mycosis observed in immunodepressed subjects. we report a case with an inaugural presentation of bullous and necrotic purpura. | 1998 | 9835962 |
| pulmonary scedosporiosis. | a case of a solitary pulmonary nodule due to scedosporium apiospermum (pseudallescheria boydii) is related. a review of the pertinent literature was done and, in addition, similar lesions caused by other opportunistic fungi are commented. | 1998 | 9876438 |
| pseudallescheria boydii infection in aids. | | 1999 | 10048912 |
| the influence of bacterial inoculants on the microbial ecology of aerobic spoilage of barley silage. | the aerobic decomposition of barley silage treated with two inoculants (laca and lacb) containing mixtures of lactobacillus plantarum and enterococcus faecium was investigated over a 28-day period. initially, yeast and bacterial populations were larger in silage inoculated with laca than in silage treated with lacb or water alone (control). differences in the succession of yeasts in silage treated with laca were observed relative to the other two treatments. from silage treatment with laca, issa ... | 1999 | 10349723 |
| [pseudallescheria boydii osteoarthritis in a patient with acute lymphoblastic leukemia: a case report]. | the outcome of neutropenic patients with pseudallescheria boydii infection is poor. | 1999 | 10365416 |
| fatal native valve endocarditis due to scedosporium apiospermum (pseudallescheria boydii) following trauma. | | 1999 | 10421053 |
| disseminated pseudallescheria boydii infection in a nonimmunocompromised host. | we present a highly unusual case of pulmonary pseudallescheria boydii infection in a nonimmunocompromised host with a cavitating mass lesion. the diagnosis was confirmed by open lung biopsy. the patient was treated at another institution with course of amphotericin b, considered an ineffective therapy for this infection, and presented to us with direct extension and invasion of the left atrial appendage and the pulmonary artery, followed by massive pulmonary embolization and hematogenous dissemi ... | 1999 | 10453893 |
| successful treatment of madura foot caused by pseudallescheria boydii with escherichia coli superinfection: a case report. | | 1999 | 10459334 |
| electrotransformation of the human pathogenic fungus scedosporium prolificans mediated by repetitive rdna sequences. | the regions encoding the 5.8s rrna and the flanking internal transcribed spacers (itsi and itsii) from two isolates of the human pathogenic fungus scedosporium prolificans and one isolate of the taxonomically related species pseudallescheria boydii (s. apiospermum) were sequenced. the sequences of the two s. prolificans isolates were identical. however, there were minor differences between both species. phylogenetic analysis of known fungal sequences confirmed a close relationship between s. pro ... | 1999 | 10459582 |
| immunoperoxidase staining for identification of aspergillus species in routinely processed tissue sections. | to evaluate the performance of an immunoperoxidase stain using the monoclonal antibody eb-a1 to detect aspergillus species in formalin fixed, paraffin wax embedded tissue. | 1996 | 8943743 |
| fungal susceptibility testing. | the utility of antifungal susceptibility testing has not been broadly determined. thus, susceptibility testing of fungal isolates is not recommended on a routine basis. for instance, susceptibilty testing may be considered for some candida species and for patients with pseudallescheria boydii infections. testing of yeasts for susceptiblity to azoles is of particular value due to their variability in response to these agents. it may also be important to test the susceptibility of new fungal organ ... | 1999 | 10571444 |
| in-situ detection of aspergillus fumigatus. | an in-situ hybridisation (ish) technique to detect aspergillus fumigatus in infected tissues was developed in which 568-bp, 333-bp and 154-bp pcr products of the alkaline proteinase gene were employed. dot-blot hybridisation with the 568-bp probe on a membrane containing genomic dna from several different fungi including a. flavus, a. niger, penicillium spp., mucor racemosus or pseudallescheria boydii gave negative results. ish was done on formalin-fixed, paraffin-embedded pulmonary tissues from ... | 2000 | 10707949 |
| antifungal activity of the new azole uk-109, 496 (voriconazole). | the in vitro activity of voriconazole fully includes aspergillus, and also emerging moulds like fusarium, pseudallescheria boydii, and penicillium marneffei. the minimal inhibitory concentrations of voriconazole for candida krusei and candida glabrata, which are resistant or less susceptible to fluconazole, promise clinical efficacy, although they are ten times higher (0.30-0.39 microgram/ml) than those for candida albicans and other candida spp. (0.001-0.05 microgram/ml). the endemic fungal pat ... | 1999 | 10865910 |
| emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty-first century. | opportunistic fungi have emerged during the past decade as important causes of morbidity and mortality in immunocompromised patients. candida species constitute the third to fourth most common causes of nosocomial blood stream infections, and aspergillus species have emerged as the most common infectious cause of pneumonic mortality in bone marrow/stem cell transplant recipients. among hiv-infected patients, meningoencephalitis due to cryptococcus neoformans ranks among the most common aids-defi ... | 1999 | 11428996 |
| endogenous pseudallescheria boydii endophthalmitis in a patient with ring-enhancing brain lesions. | a 46-year-old man, status post liver transplantation and taking immunosuppressive medications, was admitted after suffering a generalized seizure. magnetic resonance imaging of the brain revealed two ring-enhancing lesions and treatment was begun for presumed toxoplasmic encephalitis. he was already receiving amphotericin b for a skin lesion suspected to be caused by candidiasis. one day after the seizure, he complained of photophobia in the left eye. intraocular inflammation and a small infiltr ... | 2001 | 11475400 |
| vertebral osteomyelitis secondary to pseudallescheria boydii. | because pseudallescheria boydii vertebral osteomyelitis is rare and frequently resistant to available antifungal agents, the proper treatment of this lesion has not been defined. to better determine the best treatment of this lesion, the authors evaluated a case p. boydii vertebral osteomyelitis and reviewed the literature. a 48-year-old man had isolated thoracic vertebral osteomyelitis resulting from p. boydii and associated severe thoracic back pain and proximal lower extremity pain and weakne ... | 2001 | 11481561 |
| systemic antifungal agents. | anti-fungal agents are classified under two major headings, systematic and topical agents. only systematic anti-fungal agents will be discussed in this chapter. since the discovery in 1955, amphotericin b has been the cornerstone of anti-fungal treatment. it is active against most species of fungi. however, candida lusitaniae, pseudallescheria boydii, and fusarium spp have primary resistance to amphotericin b. recently, new liposomal preparations of amphotericin b have been developed. they are l ... | 2001 | 11519290 |
| uncommon opportunistic fungi: new nosocomial threats. | during the past two decades opportunistic fungal infections have emerged as important causes of morbidity and mortality in patients with severe underlying illnesses and compromised host defenses. while aspergillus and candida spp. collectively account for the majority of these infections, recent epidemiological trends indicate a shift towards infections by aspergillus spp., nonalbicans candida spp., as well as previously uncommon opportunistic fungi. apart from an expanding number of different z ... | 2001 | 11525222 |
| atypical skin lesions caused by curvularia sp. and pseudallescheria boydii in two patients after allogeneic bone marrow transplantation. | we report two patients who developed atypical skin lesions caused by curvularia sp. and pseudallescheria boydii after allogeneic bone marrow transplantation for severe aplastic anemia. the first patient (female, 18-year-old) had multiple hemorrhagic vesicles on day +30 after her second bmt for graft failure. pseudallescheria boydii was isolated from a skin biopsy. the patient died of respiratory failure probably as a consequence of systemic fungal infection. the second patient (male, 9-year-old) ... | 2001 | 11548851 |
| fungal keratitis caused by pseudallescheria boydii (scedosporium apiospermum). | keratitis is rarely caused by fungi. filamentous fungal keratitis is often preceded by corneal trauma and occurs mostly in previously healthy individuals. we studied a case of posttraumatic keratitis caused by pseudallescheria boydii, which belongs to the group of filamentous fungi. | 2000 | 11126674 |
| typing of scedosporium apiospermum by multilocus enzyme electrophoresis and random amplification of polymorphic dna. | the genetic diversity among epidemiologically unrelated strains of the human pathogenic fungus scedosporium apiospermum or its teleomorph, pseudallescheria boydii, from different areas in europe, was investigated by multilocus enzyme electrophoresis (mlee) and random amplification of polymorphic dna (rapd). fourteen enzyme activities were analysed by starch gel electrophoresis, corresponding to 27 polymorphic loci and 43 iso-enzymes. among the enzymes studied, propionate esterase, carboxyl ester ... | 2001 | 11599744 |
| pseudallescheria boydii knee arthritis in a young immunocompetent adult two years after a compound patellar fracture. | pseudallescheria boydii arthritis of the knee developed in a 32-year-old immunocompetent man 2 years after a compound patellar fracture contaminated with soil. no other potential portal of entry was identified, suggesting that the fungus remained latent for 2 years. pseudallescheria arthritis often occurs after a prolonged latency period, causing minimal symptoms that contrast with the frequently severe radiological changes. although this organism often shows limited sensitivity to most antifung ... | 2001 | 11808991 |
| fungal skin infections in organ transplant recipients. | transplantation is now currently and increasingly performed for the treatment of various acute and chronic diseases. today the kidney, heart, lung, heart-lung, liver, pancreas, kidney-pancreas, small bowel and bone marrow are being transplanted. the immunological status of patients receiving such transplants exposes them to the risk of developing bacterial, viral and fungal infections. the etiological agents of mycotic diseases involving the skin of transplant recipients range from the common de ... | 2002 | 11817966 |
| central nervous system aspergillosis: a 20-year retrospective series. | over the past 20 years at my institution, 71 patients with invasive necrotizing aspergillosis have been encountered; 42 have shown central nervous system (cns) involvement by autopsy (40) or surgical biopsy (2). most non-cns aspergillosis patients had invasive disease confined to the lung, and only 2 with dissemination to 3 or more organs did not have spread to the cns. in addition to the expected post-transplantation and hematologic malignancy cases, other risk groups identified included those ... | 2002 | 11823982 |
| fatal pseudallescheria boydii panencephalitis in a child after near-drowning. | | 1996 | 8866809 |
| in vitro activity of two echinocandin derivatives, ly303366 and mk-0991 (l-743,792), against clinical isolates of aspergillus, fusarium, rhizopus, and other filamentous fungi. | ly303366 and mk-0991 (previously l-743,792) are new echinocandin derivatives with excellent broad-spectrum antifungal activity. we investigated the in vitro activity of ly303366, mk-0991, itraconazole, amnphotericin b, and 5-flucytosine against 51 clinical isolates of filamentous fungi, including aspergillus flavus (10), a. fumigatus (12), fusarium spp. (13), rhizopus spp. (6), pseudallescheria boydii (5), and one isolate each of acremonium spp., a. niger, a terreus, paecilomyces spp., and trich ... | 1998 | 9582584 |
| pseudallescheriasis as an aggressive opportunistic infection in a bone marrow transplant recipient. | pseudallescheria boydii is a low-virulence fungus that is the main causative agent of posttraumatic mycetoma in a nonimmunocompromised host. immunocompromised patients are at high risk for locally invasive or disseminated pseudallescheria infection. however, aggressive opportunistic infections due to p boydii are reported infrequently because it morphologically resembles other fungi, especially aspergillus species, on tissue histology; therefore, such infections are not identified and treated pr ... | 2002 | 11825121 |
| cutaneous infection showing sporotrichoid spread caused by pseudallescheria boydii (scedosporium apiospermum): successful detection of fungal dna in formalin-fixed, paraffin-embedded sections by seminested pcr. | | 2002 | 11843660 |
| pulmonary scedosporium infection following lung transplantation. | infectious complications are frequent following lung transplantation. tracheobronchial aspergillosis is the predominant fungal infection in these patients. infections with scedosporium apiospermium (pseudoallescheria boydii) and scedosporium prolificans (scedosporium inflatum) have mainly been described in bone marrow transplant recipients and only occasionally in solid organ transplant recipients. we analysed risk factors, the clinical course and outcome of seven lung transplant recipients who ... | 2001 | 11844150 |
| [nine cases of maduromycosis in the belgian congo caused by allescheria boydii, monosporium apiospermum and nocardia madurae]. | | 1954 | 13229089 |
| a chemically modified tetracycline (cmt-3) is a new antifungal agent. | several chemically modified tetracycline analogs (cmts), which were chemically modified to eliminate their antibacterial efficacy, were unexpectedly found to have antifungal properties. of 10 cmts screened in vitro, all exhibited antifungal activities, although their efficacies varied. among these compounds, cmt-315, -3, and -308 were found to be the most potent as antifungal agents. the mics of cmt-3 against 47 strains of fungi in vitro were determined by using amphotericin b (amb) and doxycycl ... | 2002 | 11959581 |
| an abortion due to allescheria boydii and general observations concerning mycotic abortions of mares. | | 1965 | 14331433 |
| scedosporium apiospermum fungemia in a lung transplant recipient. | scedosporium apiospermum, the asexual anamorph of the cosmopolitan fungus pseudallescheria boydii, is emerging as an important cause of disseminated infection in immunocompromised patients. we present our experience with the first reported case of s apiospermum fungemia in a lung transplant patient. disseminated infection resulted in sepsis, multiorgan failure, and death. review of the literature highlights the diagnostic difficulties related to the similarities between s. apiospermum and asperg ... | 2002 | 12006471 |
| chronic sino-naso-orbital fungal infection due to pseudallescheria boydii in a nonimmunocompromised host--a case report. | a case of recurrent sino-naso-orbital fungal infection due to pseudallescheria boydii described in a 28 yrs. old man, who appeared immunocompetent, and was found negative for hiv i and ii by elisa tested on two occasions. the fungal culture was negative. it is very essential to identify p boydii as miconazole is the only antifungal drug of choice for this fungus. the pathologist plays an important role in identifying this fungus when fungal culture fails to yield the growth. the pathologist has ... | 2001 | 12024935 |
| characterization of glucosylceramides in pseudallescheria boydii and their involvement in fungal differentiation. | pseudallescheria boydii is a fungal pathogen that causes disease in immunocompromised patients. ceramide monohexosides (cmhs) were purified from lipidic extracts of this fungus, showing that, as described for several other species, p. boydii synthesizes glucosylceramides as major neutral glycosphingolipids. cmhs from p. boydii were analyzed by high-performance thin-layer chromatography, gas chromatography coupled to mass spectrometry, fast atom bombardment-mass spectrometry, and nuclear magnetic ... | 2002 | 12042248 |
| antifungal triazoles and polymorphonuclear leukocytes synergize to cause increased hyphal damage to scedosporium prolificans and scedosporium apiospermum. | scedosporium prolificans and scedosporium apiospermum (pseudallescheria boydii) cause pulmonary and disseminated infections refractory to most currently used antifungal agents in immunocompromised patients. we therefore investigated the potential antifungal activities of the triazoles itraconazole (itc), voriconazole (vrc), and posaconazole (psc) in combination with human polymorphonuclear leukocytes (pmns) against the hyphae of these fungal pathogens. a colorimetric assay with (2,3-bis[2-methox ... | 2002 | 12069979 |
| scedosporium apiospermum (pseudallescheria boydii) endocarditis. | scedosporium apiospermum, the asexual state of pseudallescheria boydii, is increasingly recognized as an opportunistic pathogen. we report a case of native valve endocarditis due to this organism that developed in an elderly patient following a prolonged hospitalization. literature on endocarditis caused by s. apiospermum and p. boydii is reviewed. | 2002 | 12099748 |
| a peptidorhamnomannan from the mycelium of pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen. | the ascomycete pseudallescheria boydii is an emerging human pathogen frequently found in soil and polluted water. a peptidopolysaccharide antigen has been isolated from mycelial forms of p. boydii, and characterized using chemical and immunological methods. monosaccharide composition, methylation analysis, and (1)h- and (13)c-nmr spectra indicated the presence of a rhamnomannan with a structure distinct from those of similar components isolated from other fungi, containing rhap(1-->3)rhap epitop ... | 2001 | 11390680 |
| pseudallescheria boydii (anamorph scedosporium apiospermum). infection in solid organ transplant recipients in a tertiary medical center and review of the literature. | (sca) is a ubiquitous filamentous fungus capable of causing invasive disease. we reviewed our electronic microbiology records and the english-language literature. between 1976 and december 1999 we identified 23 solid organ transplant recipients with sca infection, 7 of which occurred between december 1987 and december 1999 at our institution. overall incidence was 1 per 1,000 patients, with a trend of higher incidence in patients receiving lung transplants compared with other transplant organs ( ... | 2002 | 12352630 |
| an immunocompetent patient with primary scedosporium apiospermum vertebral osteomyelitis. | scedosporium apiospermum, the asexual anamorph of pseudallescheria boydii, is a ubiquitous saprophytic fungus that usually causes cutaneous/subcutaneous infection but may manifest as an invasive disease, often in immunocompromised hosts. following an extensive literature review, we think that this case represents the first documented report of a primary infection of the spine in an immunocompetent patient. despite extensive surgical debridement and itraconazole therapy, the patient died of multi ... | 2002 | 12394669 |
| case reports. infection due to scedosporium apiospermum in renal transplant recipients: a report of two cases and literature review of central nervous system and cutaneous infections by pseudallescheria boydii/sc. apiospermum. | two cases of infections due to scedosporium apiospermum in renal transplant recipients, one localized in the central nervous system, the other in the skin, are presented, and a literature review of 21 cases of central nervous system and cutaneous infections due to pseudallescheria boydii/sc. apiospermum is given. | 2002 | 12421295 |
| mycotic aneurysms as lethal complication of brain pseudallescheriasis in a near-drowned child: a ct demonstration. | intracranial true mycotic aneurysms are rare and generally lethal. we report a case of a near-drowned child with brain abscesses due to pseudallescheria boydii, a saprophytic fungus, who died after subarachnoid hemorrhage occurred. ct showed contrast-enhancing lesions indicative of aneurysms of basilar and right posterior cerebral arteries that could not be appreciated 2 days before. p. boydii is often resistant to commonly used antimycotic drugs. because cns infection is frequently associated w ... | 2002 | 12427626 |
| mycetoma due to pseudallescheria boydii and co-isolation of nocardia abscessus in a patient injured in road accident. | we report the case of a patient who developed a mycetoma after experiencing a road accident. from surgical biopsies pseudallescheria boydii was isolated. subsequently, after the infection had been treated with itraconazole, a gram-positive bacterium, identified as the newly described species nocardia abscessus, was cultured from wound fluids. | 2002 | 12462533 |
| scedosporium apiospermum pneumonia and sternal wound infection in a heart transplant recipient. | the most common fungi that cause invasive infection in transplant recipients are the spp, spp, and the endemic fungi such as and. recently, however, other fungal pathogens have emerged as important causes of invasive disease in these immunocompromised individuals, including the dematiaceous fungi, such as and the spp, species of and, and the hyalohyphomycoses, such as (pseudallescheria boydii) (1). | 2002 | 12490804 |
| disseminated pseudallescheria boydii (scedosporium apiospermum) infection in a renal transplant patient. | transplant recipients receive a number of immunosuppressive medications that result in an increased risk of infection, including infections with microbes that are normally not pathogenic. we describe a patient with end-stage renal disease who underwent kidney transplantation. six months postoperatively, he presented with a lesion on his ankle, multiple thigh nodules, and right testicular pain. biopsy of the ankle lesion demonstrated pseudallescheria boydii (scedosporium apiospermum), a common en ... | 2002 | 12535264 |
| breakthrough scedosporium apiospermum (pseudallescheria boydii) brain abscess during therapy for invasive pulmonary aspergillosis following high-risk allogeneic hematopoietic stem cell transplantation. scedosporiasis and recent advances in antifungal therapy. | systemic scedosporiasis due to the anamorph or asexual form scedosporium apiospermum (pseudallescheria boydii) has become an important cause of opportunistic mycosis, especially in patients undergoing high-risk hematopoietic stem cell transplantation. we report a case of rapidly progressive cerebellar hyalohyphomycosis due to scedosporium apiospermum in an allogeneic marrow graft recipient receiving treatment for severe graft-versus-host disease. this fatal breakthrough intracranial abscess, due ... | 2002 | 12535265 |
| detection and identification of fungi from fungus balls of the maxillary sinus by molecular techniques. | the aim of this study was to find a reliable method for the detection and identification of fungi in fungus balls of the maxillary sinus and to evaluate the spectrum of fungi in these samples. one hundred twelve samples were obtained from patients with histologically proven fungal infections; 81 samples were paraffin-embedded tissue sections of the maxillary sinus. in 31 cases, sinus contents without paraffin embedding were sent for investigation. pcr amplification with universal fungal primers ... | 2003 | 12574250 |
| involvement of peptidorhamnomannan in the interaction of pseudallescheria boydii and hep2 cells. | pseudallescheria boydii is an emerging fungal pathogen that has a worldwide distribution. virulence mechanisms of p. boydii are largely unknown. we studied the interaction between p. boydii and hep2 cells and demonstrated that conidia of p. boydii attached to, and were ingested by, hep2 cells in a time-dependent process. after 2 h of interaction, the conidia produced a germ-tube like projection, which was able to penetrate the epithelial cell membrane. recently, our group characterized a peptido ... | 2004 | 15555531 |
| cutaneous infection due to scedosporium apiospermum in an immunosuppressed patient. | scedosporium apiospermum, the anamorphic form of pseudallescheria boydii, is a filamentous fungus with low inherent virulence. increasing numbers of cases of this infection have been reported probably related to the rising number of immunosuppressed persons. apart from mycetoma, cutaneous and subcutaneous infection is rarely encountered in clinical practice. we describe a case of cutaneous infection caused by scedosporium apiospermum in a subject with rheumatoid arthritis and diabetes mellitus w ... | 2003 | 12602968 |
| in situ hybridization for the differentiation of aspergillus, fusarium, and pseudallescheria species in tissue section. | identification of fungi in tissue sections can be difficult. in particular, species of aspergillus, fusarium, and pseudallescheria all appear as septate, branched hyphae. however, their differentiation can have significant clinical implications, as the latter two groups are often resistant to commonly used antifungal agents. in situ hybridization may assist in rapidly distinguishing these organisms in the absence of available culture. oligonucleotide dna probes were directed against the 5s, 18s, ... | 2003 | 12605032 |
| [mycetoma: 130 cases]. | mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. it follows penetrating injury inoculating soil organisms, occurring preferentially in rural areas usually among labourers who work barefoot. mycetoma is a localized chronic, and deforming infectious disease of subcutaneous tissues, skin and bones. we report 130 cases of mycetoma in senegal from 1983 to 2000. | 2003 | 12605151 |
| activity of posaconazole against pseudallescheria boydii: in vitro and in vivo assays. | thirty isolates of pseudallescheria boydii were tested to compare the in vitro activity of posaconazole with those of fluconazole and itraconazole, using nccls methods. posaconazole was evaluated in an immunosuppressed mouse model of disseminated pseudallescheriasis. posaconazole was more effective than itraconazole and as effective as fluconazole in preventing death and significantly reducing the cfu of p. boydii from tissues. | 2003 | 12654687 |
| [mycetomas in central tunisia]. | mycetomas are inflammatory pseudo-tumors containing fungal or actinomycosic-type grains. they are frequent in tropical and subtropical countries and unknown in tunisia. | 2003 | 12843827 |
| scedosporium apiospermum keratitis treated with itraconazole. | mycotic keratitis usually occurs in conjunction with trauma to the cornea. scedosporium apiospermum, a dematiaceous fungus linked to the teleomorph pseudallescheria boydii is not a common agent of mycotic keratitis. a 22-year old male patient with mycotic keratitis due to s. apiospermum is presented. in in vitro susceptibility testing, the isolate showed resistance against amphotericin b (minimum inhibitory concentration [mic] 16 microg ml(-1)) but was susceptible to itraconazole (itc) and fluco ... | 2003 | 12964842 |
| onychomycosis in white line disease in horses: pathology, mycology and clinical features. | this paper describes onychomycosis in horses and reports the pathological findings, associated fungi and incidence of concurrent white line disease. in addition to these observations, relevance between post mortem and clinical findings of onychomycosis are discussed in 3 necropsied horses. samples were collected from 100 hooves from a total of 51 thoroughbreds suffering from white line disease. of these, 15 hooves from 13 horses were also complicated with severe hoof wall fissure formation. prep ... | 1998 | 9932091 |
| human phagocytic cell responses to scedosporium apiospermum (pseudallescheria boydii): variable susceptibility to oxidative injury. | scedosporium apiospermum (pseudallescheria boydii) is an emerging opportunistic filamentous fungus that causes serious infections in both immunocompetent and immunocompromised patients. to gain insight into the immunopathogenesis of infections due to s. apiospermum, the antifungal activities of human polymorphonuclear leukocytes (pmns), mononuclear leukocytes (mncs), and monocyte-derived macrophages (mdms) against two clinical isolates of s. apiospermum were evaluated. isolate sa54a was amphoter ... | 2003 | 14573669 |
| infection of the cns by scedosporium apiospermum after near drowning. report of a fatal case and analysis of its confounding factors. | this report describes a fatal case of central nervous system pseudallescheriasis. a 32 year old white man presented with headache and meningismus 15 days after nearly drowning in a swine sewage reservoir. computerised tomography and magnetic resonance imaging of the head revealed multiple brain granulomata, which vanished when steroid and broad spectrum antimicrobial and antifungal agents, in addition to dexamethasone, were started. cerebrospinal fluid analysis disclosed a neutrophilic meningiti ... | 2004 | 14747453 |
| structure and biological functions of fungal cerebrosides. | ceramide monohexosides (cmhs, cerebrosides) are glycosphingolipids composed of a hydrophobic ceramide linked to one sugar unit. in fungal cells, cmhs are very conserved molecules consisting of a ceramide moiety containing 9-methyl-4,8-sphingadienine in amidic linkage to 2-hydroxyoctadecanoic or 2-hydroxyhexadecanoic acids, and a carbohydrate portion consisting of one residue of glucose or galactose. 9-methyl 4,8-sphingadienine-containing ceramides are usually glycosylated to form fungal cerebros ... | 2004 | 15048196 |
| respiratory tract intracavitary colonization due to scedosporium apiospermum: report of four cases. | four cases of respiratory tract intracavitary colonization (fungus ball) due to scedosporium apiospermum (teleomorph, pseudallescheria boydii) are reported. the need for a careful search for anneloconidia, in order to establish the etiologic diagnosis in the clinical specimen by microscopy, is emphasized. | 2004 | 15057335 |
| experimental murine model of disseminated pseudallescheria infection. | pseudallescheria boydii is found in soil and has a worldwide distribution. this fungus was initially identified as a pathogen targeting a variety of tissues. there are fragmentary data in the literature on the in vitro susceptibility of p. boydii to different antifungal compounds. p. boydii is highly refractory to antifungal treatments. in this study, a murine model of disseminated pseudallescheria infection was developed to evaluate efficacy of different treatment regimens. a clinical strain of ... | 2002 | 12146753 |
| primary cutaneous fungal infections in solid organ transplantation: a case series. | cutaneous fungal infections in solid-organ transplant patients present in a variety of nonspecific ways, requiring a high index of suspicion to diagnose correctly. in the present series of four transplant recipients, subsequent primary cutaneous fungal infections presented as papules, plaques, ulcers and subcutaneous nodules. transplantations included one cardiac, two renal and one renal-pancreatic transplant. fungal infections were limited to the skin; there was no evidence of disseminated dise ... | 2002 | 12201372 |
| testicular involvement in disseminated fungal infection by pseudallescheria boydii. | we present an immunocompromised patient with a painless testicular mass. usually, this mass is suspicious for testicular cancer; however, a fungal abscess from pseudallescheria boydii was found. the patient eventually died from disseminating infection. this is the first such report of a testicular infection involving p. boydii. early diagnosis and treatment are paramount because of the poor outcome with disseminated disease. | 2004 | 15134998 |
| pseudoallescheria boydii pneumonia and empyema: a rare complication of heart transplantation cured with voriconazole. | pseudoallescheria boydii pneumonia is a rare occurrence, usually resistant to amphotericin b and other anti-fungal agents. we report a complete response to voriconazole in an immunosuppressed host. | 2004 | 15135387 |
| meningitis caused by pseudallescheria boydii. | we present a 43-year-old immunocompetent man who developed meningitis caused by pseudallescheria boydii. the patient had no history of near drowning, trauma, steroid administration, operations or any other underlying systemic disease. he presented with intermittent fever associated with headache, bilateral eye pain, and vomiting. progressive hydrocephalus was noted during the course of the disease. cerebrospinal fluid (csf) from the ventricular system allowed culture of the organism. although th ... | 2004 | 15149002 |
| otitis caused by scedosporium apiospermum in an immunocompetent child. | scedosporium apiospermum (pseudallescheria boydii) is a ubiquitous saprophytic mold. it is considered an infrequent but important and emerging human pathogen, mostly in immunocompromised hosts. otomycosis secondary to s. apiospermum is extremely rare. we report an 8-year-old immunocompetent male who developed otitis media and otitis externa from s. apiospermum, which was successful treated with combination of surgical debridement and topical clotrimazole therapy. a brief literature review of inf ... | 2004 | 15183592 |
| pulmonary pseudallescheria boydii infection with cutaneous zygomycosis after near drowning. | pseudallescheria boydii is a ubiquitously occurring fungus. while rarely causing opportunistic infection in humans, it is the most common cause of fungal pneumonia in cases of near drowning, and is associated with high mortality. p. boydii typically causes cutaneous mycetomas but may invade the lungs or brain. p. boydii infections are difficult to treat due to amphotericin b resistance and frequent need for surgical resection. zygomycetous infections, often referred to as "mucormycoses," usually ... | 2004 | 15301126 |
| [successful treatment with voriconazol of a pseudallescheria boydii fungus ball in a hiv positive patient and previous tuberculosis]. | we herein describe a patient with a pseudallescheria boydii fungus ball in a tuberculous lung cavity, which was successfully treated four years earlier. the patient was hiv positive classified as c3 with a previous history of i.v. heroin abuse. the clinical presumptive diagnosis was radiologically established combined with histological examination. culture of tissue confirmed and proved the fungal etiology. in vitro mic values for voriconazole (0.5 mg/ml) guided antifungal prophylactic treatment ... | 2003 | 15456374 |
| orbital apex syndrome secondary to pseudallescheria boydii fungal sinusitis in an immunocompetent patient. | orbital apex syndrome secondary to mucormycosis in immuno-compromised patients is well described; however, few reports exist of a paranasal sinus mycetoma resulting in this presentation in the immuno-competent patient. the case is reported of a 92-year-old man who developed orbital apex syndrome secondary to a sphenoidal sinus mycetoma of pseudallescheria boydii. | 2004 | 15498073 |
| pseudallescheria boydii cranial osteomyelitis and subdural empyema successfully treated with voriconazole: a case report and literature review. | described here is a case of pseudallescheria boydii cranial osteomyelitis and subdural empyema following craniotomy, which was successfully treated with surgical debridement and voriconazole. other reported cases of pseudallescheria boydii osteomyelitis are reviewed. the reported case suggests that voriconazole may represent a new therapeutic option for this infection. | 2004 | 15558341 |
| pulmonary pseudallescheriasis in a patient with healed tuberculosis. | pulmonary pseudallescheriasis in an immunocompetent patient without a pre-existing cavity or cyst is a rare phenomenon. we report a case of invasive pulmonary pseudallescheriasis in a lobectomised patient treated for tuberculosis. filamentous fungi with pyriform conidia were seen in the bronchoalveolar lavage fluid . the fungus was identified as pseudallescheria boydii on culture. | 2004 | 15645170 |
| cutaneous scedosporium apiospermum infection in an immunocompromised patient and a review of the literature. | scedosporium apiospermum (also known as pseudallescheria boydii) is a ubiquitous filamentous fungus. this fungus is known as a cause of mycetoma, which may occur in a normally immune host following trauma. however, in an immunocompromised host, s. apiospermum may cause a life-threatening infection. we describe a case of s. apiospermum infection of the right hand in a patient who was receiving long-term immunosuppressants for adult still's disease. we also review the cases of s. apiospermum infec ... | 2005 | 15823912 |
| successful treatment of multiple pseudallescheria boydii brain abscesses and ventriculitis/ependymitis in a 2-year-old child after a near-drowning episode. | we report on a cerebral infection by pseudallescheria boydii in a 21-month-old boy after a near-drowning episode. mri revealed multiple (> 60) intracerebral abscesses. | 2006 | 15864705 |
| structures of the o-linked oligosaccharides of a complex glycoconjugate from pseudallescheria boydii. | nonreducing o-linked oligosaccharides were obtained from the peptidorhamnomannan of mycelia of pseudallescheria boydii by alkaline beta-elimination under reducing conditions. they were separated by gel filtration chromatography to give three oligosaccharide fractions. the major oligosaccharide from fraction 1 was characterized by a combination of techniques including electrospray ionization quadrupole time-of-flight tandem mass spectrometry (esi ms/ms), matrix-assisted laser desorption ionizatio ... | 2005 | 15932920 |
| pulmonary pseudallescherioma associated with systemic lupus erythematosus. | we report a case of fungus ball due to pseudallescheria boydii (pseudallescherioma) associated with systemic lupus erythematosus. direct microscopical examination revealed a fungus with broad septate hyphae resembling aspergillus and the fungus was identified as p. boydii on culture. surgical resection was required to control episodes of hemoptysis. cases of pulmonary pseudallescheriasis are rare, especially in japan. however, some cases previously diagnosed as pulmonary aspergillosis may have b ... | 1998 | 9932639 |
| scedosporium/pseudallescheria infections. | the genus scedosporium comprises a group of filamentous fungi found ubiquitously in the environment. the two major human pathogens within this genus are s. apiospermum-the asexual state of pseudallescheria boydii-and s. prolificans. both histologically resemble aspergillus species, with hyphae that are septated and branching at acute angles. although scedosporium infections can occur in immunocompetent persons, the overall incidence has increased over the last decade as a consequence of improved ... | 2004 | 16088460 |
| scedosporium apiospermum brain abscess treated with surgery and voriconazole. case report. | scedosporium apiospermum is a fungus found in the soil and in contaminated water. common cutaneous manifestations include madura foot, a painless swelling on the sole of the foot. invasive infection is usually associated with immunosuppression. the authors present a 16-month-old immunocompetent boy who had a near-drowning event. following this, he was severely disabled with spastic quadriparesis. early computerized tomography scans revealed diffuse hypoxic injury. magnetic resonance images obtai ... | 2005 | 16122011 |
| activity of posaconazole in the treatment of central nervous system fungal infections. | a multinational, multicentre, open-label clinical trial was conducted to evaluate the safety and efficacy of posaconazole, an extended-spectrum triazole antifungal agent, in subjects with invasive fungal infections who had refractory disease or who were intolerant of standard antifungal therapy. in this subanalysis, we report on those subjects in this trial who had a fungal infection that involved the cns. | 2005 | 16135526 |
| pseudallescheriasis in the 21st century. | since its discovery as an agent of mycetoma nearly a century ago, pseudallescheria boydii with its asexual (synanamorphic) form, scedosporium apiospermum, is now recognized as an important emerging opportunistic pathogen causing invasive mycosis in immunocompromised patients. the clinical spectrum of pseudallescheriasis is wide. invasive disease of the lung, cns and dissemination are serious manifestations in immunocompromised patients. this organism responds poorly to amphotericin b, and its hi ... | 2005 | 16207168 |
| molecular phylogeny of the pseudallescheria boydii species complex: proposal of two new species. | pseudallescheria boydii (anamorph scedosporium apiospermum) is the species responsible for human scedosporiosis, a fungal infection with a high mortality rate and which is difficult to treat. recently, it has been demonstrated that high genetic variation exists within this species. we have performed a morphological and molecular study involving numerous strains of clinical or environmental origins and from different countries. the analysis of partial sequences of the beta-tubulin (two loci) and ... | 2005 | 16207945 |
| disseminated pseudallescheria boydii infection successfully treated with voriconazole. | | 2005 | 16291910 |
| in vitro activity of anidulafungin against selected clinically important mold isolates. | in this study, we evaluated the in vitro activity of anidulafungin against selected mold isolates. anidulafungin showed promising activity against bipolaris spicifera, exophiala jeanselmei, fonsecaea pedrosoi, madurella mycetomatis, penicillium marneffei, phialophora verrucosa, pseudallescheria boydii, sporothrix schenckii, and wangiella dermatitidis. | 2004 | 15105159 |
| susceptibility of pseudallescheria boydii and scedosporium apiospermum to new antifungal agents. | hyalohyphomycoses caused by pseudallescheria boydii and scedosporium apiospermum have recently been on the increase. to find the appropriate treatment for this emerging disease, we examined the antifungal susceptibility of 10 isolates of p. boydii and 17 isolates of s. apiospermum, most of which were isolated from clinical specimens. when the nccls m38-p microdilution method was used, itraconazole showed strong antifungal activities, while amphotericin b had little efficacy. a new triazole agent ... | 2004 | 15118667 |
| subcutaneous infection with pseudallescheria boydii in an immunocompromised patient. | with the broad employment of immunosuppressive therapy, the incidence of pseudallescheria boydii infections is rising. we report a first case of the localized subcutaneous p. boydii infection in a patient with microscopic polyangiitis. favorable outcome related to the treatment with voriconazole adds to the growing body of evidence supporting the use of this particular agent in p. boydii infections. | 2007 | 16572287 |
| pseudallescheria boydii keratitis. | we describe a patient with pseudallescheria boydii keratitis. the treatment of mycotic keratitis remains difficult. this case demonstrates that identification and susceptibility testing should be rapidly performed. in cases of indolent keratitis, the possibility of fungal infection should be kept in mind. | 2006 | 16598981 |
| periocular abscess caused by pseudallescheria boydii after a posterior subtenon injection of triamcinolone acetonide. | a posterior subtenon injection of triamcinolone acetonide is an alternative to intravitreal injection in diabetic macular edema and is known to have fewer vision-threatening complications. here, we report a case of periocular abscess following posterior subtenon injection of triamcinolone. | 2007 | 16612634 |
| [pseudoallescheria boydii (scedosporium apiospermum), cause of mycotic granulomatous osteomyelitis--case diagnosis]. | fungal bone infections constitute about 0.1-0.2% of all osteomyelitis cases. the disease, mycetoma pedis, most often affects the feet and is also known as madura foot. mycetoma, extremely rare in this geographic area, is endemic in tropical and subtropical regions. we present a case of mycetoma pedis (madura foot). the patient was a 50-year-old woman. the clinical signs included pain, indurations, and local redness. the anamnesis was very long, about 10 years. the operative material was routinel ... | 2005 | 16623262 |
| an alpha-glucan of pseudallescheria boydii is involved in fungal phagocytosis and toll-like receptor activation. | the host response to fungi is in part dependent on activation of evolutionarily conserved receptors, including toll-like receptors and phagocytic receptors. however, the molecular nature of fungal ligands responsible for this activation is largely unknown. herein, we describe the isolation and structural characterization of an alpha-glucan from pseudallescheria boydii cell wall and evaluate its role in the induction of innate immune response. these analyses indicate that alpha-glucan of p. boydi ... | 2006 | 16766532 |
| scedosporium apiospermum: changing clinical spectrum of a therapy-refractory opportunist. | current knowledge on the opportunist scedosporium apiospermum (teleomorph: pseudallescheria boydii), generated over a period of more than 120 years, is reviewed. the natural environmental habitat of the fungus is unknown; nutrient-rich, brackish waters like river estuaria have been suggested. the fungus is strongly promoted by agricultural and particularly by industrial pollution. | 2006 | 16772225 |
| extracellular peptidase in the fungal pathogen pseudallescheria boydii. | pseudallescheria boydii is a ubiquitous filamentous fungus capable of causing invasive disease in humans. in the present study, using sodium dodecyl sulfate-polyacrylamide gels containing bovine serum albumin as co-polymerized substrate, we identified a 28-kda proteolytic activity released to the extracellular environment by mycelia of p. boydii. this peptidase was detected during the growth of p. boydii in sabouraud-dextrose medium for 13 days and reached its maximal production on day 7. the 28 ... | 2006 | 16775782 |
| polycytella hominis is a mutated form of scedosporium apiospermum. | pcr amplification and sequencing of two separate regions of the nuclear ribosomal repeat region revealed that polycytella hominis, a hyphomycete isolated from a human case of mycetoma, was genetically indistinguishable from scedosporium apiospermum (the anamorph of pseudallescheria boydii). these organisms also exhibited remarkably similar susceptibility profiles to common antifungal agents. p. hominis is thus likely to be a mutant of s. apiospermum showing abnormalities of sporulation, for whic ... | 2006 | 16805091 |
| endobronchial fungal disease: an under-recognized entity. | most fungi enter the human body via inhalation; however, endobronchial fungal infection (ebfi) seems to be a rare manifestation compared to pulmonary or systemic disease. this presentation seems to be related to environmental factors as well as to the host status. with the increasing popularity of flexible bronchoscopy, it is being recognized with a higher frequency. bronchoscopic findings in ebfi vary from mild mucosal inflammation to central airway obstruction. we searched english literature r ... | 2007 | 16864987 |
| phytochemistry and antifungal properties of the newly discovered tree pleodendron costaricense. | gas chromatography analysis of the essential oils of leaves and bark collected from the newly discovered tree pleodendron costaricense identified alpha-pinene, beta-pinene, beta-myrcene, beta-thujene, and beta-caryophyllene as their major constituents. phytochemical analysis of p. costaricense parts led to the isolation and identification of delta-tocotrienol, beta-sitosterol, four known drimane-type sesquiterpenes, cinnamodial (1), cinnamosmolide (2), polygodial (3), and mukaadial (4), and two ... | 2006 | 16872133 |
| lethal brain abscess due to the fungus scedosporium apiospermum (teleomorph pseudallescheria boydii) after a near-drowning incident: case report and review of the literature. | a 39-year-old healthy man developed a brain abscess weeks after a near-drowning incident. scedosporium apiospermum, the anamorph of pseudallescheria boydii, was isolated from the abscess. the patient died 153 days after the accident despite antifungal therapy. we discuss the role of antifungals and review the literature for comparable cases. | 2006 | 16882615 |
| antifungal susceptibilities of the species of the pseudallescheria boydii complex. | eighty-four isolates belonging to eight species that constitute the pseudallescheria boydii complex were tested against 11 antifungal agents by using the microdilution method. there were significant differences among the species, with scedosporium aurantiacum being the most resistant. in general, voriconazole was the most active drug, followed by posaconazole. | 2006 | 17015631 |
| pseudallescheria boydii keratitis. | a case of pseudallescheria boydii keratitis is presented. the patient was successfully treated with topical natamycin and systemic itraconazole in conjunction with penetrating keratoplasty, leading to visual acuity of 20/40. | 2006 | 17148086 |
| pseudallescheriasis: a summary of patients from 1980-2003 in a tertiary care center. | pseudallescheria boydii is being increasingly isolated in immunocompromised patients. | 2006 | 17149961 |
| invasive fungal sinusitis caused by pseudallescheria boydii: case report and literature review. | fungal sinusitis secondary to pseudallescheria boydii is rare, as only 25 cases have been previously reported in the literature. although pboydii resembles aspergillus on pathologic examination, it is typically resistant to amphotericin b. therefore, culture is necessary to differentiate the two. patients with p boydii sinusitis should generally be treated with a combination of surgery and antifungal therapy. combination treatment is particularly important for immunocompromised patients with fun ... | 2006 | 17168149 |
| fungal endocarditis caused by pseudallescheria (petriellidium) boydii in an intravenous drug abuser. | we present a case of fungal endocarditis in a 42-year-old man with a history of intravenous drug abuse who required aortic valve replacement for severe aortic insufficiency. cultures of the resected valve grew pseudallescheria boydii. the patient subsequently developed persistent endocarditis of the prosthetic valve with systemic embolism. at autopsy, cultures of the prosthetic valve grew monosporium apiospermum, an anamorph of pseudallescheria boydii. although fungal endocarditis is not uncommo ... | 1987 | 15227321 |
| isolation of histoplasma capsulatum and allescheria boydii from soil. | | 1951 | 14845707 |