| pattern of dermatophytoses in and around varanasi. | four hundered cases of dermatophytoses confirmed microscopically, were analysed. it was more common in 11 to 20 years age group mid males. females acquired tinea corporis more commonly. tinea cruris was more frequent in males. ma3dmum cases were of tinea cruris followed by tinea cruris et corpmis and tinea corporis in that order. the isolation rate on culture was 70.75%. the relative incidence of trichophyton rubrum was maximum and it was found in all clinical entities. | 2017 | 28164906 |
| a clinico-mycological study of tinea pedis in north-eastern india. | a total of 2306 patients were examined for ' the clinical evidence of tinea pedis. only 52 of these were found to suffer from this condition. trichophyton rubrum was the commonest (47.6%) isolate and it produced predominantly non-inflammatory scaly lesions. t mentagrophytes was the next commonest (21.4%) agent: it was responsible for most of the macerated lesions. | 2017 | 28164875 |
| a comparison of antigens of trichophytion rubrum obtained by some methods of preparation. | westphal's and reyes and friedman's methods of extraction were used to study the antigens of trichophyton rubrum. three types of antigens were compared - phenolic (p) and aqueous (a) materials from mechanically ground organisms, precipitated by increasing gradients of ethanol and extra cellular (x) metabolites (concentrated medium) precipitated by increasing gradients of acetone. there was no yield after concentration of 75% for both ethanol and acetone. the extra cellar material (x) had the max ... | 2017 | 28176742 |
| infections due to trichophyton rubrum. | trichophyton rubrum is the most common dermatophyte encountered in our. | 2017 | 28176700 |
| onychomycosis in an infant. | distal subungual onychomycosis, caused by trichophyton rubrum, in an otherwise healthy three months old infant, is described. this appears to be the youngest patient with this disease reported in the english literature. | 2017 | 28176734 |
| dermatophytoses in davangere. | a clwco- mycological study of 130 cases of dermatophytoses undertaken during a period of i year is reported. the age and sex incidence, the clinical varieties. land the seasonal variations are analysed. the infection was predominantly seen in the age group of 11-50 years. men were more commonly affected. tinea glabrosa (89.249o) was the commonest clinical type encountered, followed by tinea capitis (6.93%). ar the cases were positive by direct microscopic examination and the different species of ... | 2017 | 28193927 |
| biomedical applications of green synthesized nobel metal nanoparticles. | synthesis of nobel metal nanoparticles, play a key role in the field of medicine. plants contain a substantial number of organic constituents, like phenolic compounds and various types of glycosides that help in synthesis of metal nanoparticles. synthesis of metal nanoparticles by green method is one of the best and environment friendly methods. the major significance of the green synthesis is lack of toxic by-products produced during metal nanoparticle synthesis. the nanoparticles, synthesized ... | 2017 | 28582711 |
| dna interaction, antimicrobial, anticancer activities and molecular docking study of some new vo(ii), cr(iii), mn(ii) and ni(ii) mononuclear chelates encompassing quaridentate imine ligand. | the present study was conducted to synthesis of some new imine cr(iii), vo(ii), mn(ii) and ni(ii) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. the prepared hnpn imine ligand was analyzed by its melting point, ir, (1)h nmr and (13)c nmr spectroscopies. the investigated hnpn imine complexes were characterized by elemental analysis, ft ir, uv-vis and thermal analysis (tga) under nitrogen atmosphere from ambient temperature to 750°c. the exp ... | 2017 | 28456118 |
| etiology of onychomycosis in patients, turkey. | onychomycosis is the chronic infection of the nails, and it is caused by dermatophytes, candida, non- dermatophyte molds, trichosporon genus. | 2017 | 28594608 |
| production, characterization, and antimicrobial activity of mycocin produced by debaryomyces hansenii dsmz70238. | the present study was conducted to estimate the antimicrobial activity and the potential biological control of the killer toxin produced by d. hansenii dsmz70238 against several pathogenic microorganisms. in this study, the effects of nacl, ph, and temperature, killer toxin production, and antimicrobial activity were studied. the results showed that the optimum inhibitory effect of killer toxin was at 8% nacl, and the diameters of clear zones were 20, 22, 22, 21, 14, and 13 mm for staphylococcus ... | 2017 | 28757872 |
| terbinafine resistance of trichophyton clinical isolates caused by specific point mutations in the squalene epoxidase gene. | terbinafine is one of the allylamine antifungal agents whose target is squalene epoxidase (sqle). this agent has been extensively used in the therapy of dermatophyte infections. the incidence of patients with tinea pedis or unguium tolerant to terbinafine treatment prompted us to screen the terbinafine resistance of all trichophyton clinical isolates from the laboratory of the centre hospitalier universitaire vaudois collected over a 3-year period and to identify their mechanism of resistance. a ... | 2017 | 28416557 |
| composition and antifungal activity of zhumeria majdae essential oil. | essential oils extracted from different plants are extensively used in perfume, beverage, and food industries and are reported to exhibit antimicrobial activities against a variety of fungi. zhumeria majdae belonging to the lamiaceae family is a rare and endemic medicinal plant species in iran, with a strong and pleasant odor. the leaves of this plant have been used for many years as an antiseptic carminative agent for the treatment of stomachache (especially in infants) and dysmenorrhea. | 2015 | 28680999 |
| longterm storage of post-packaged bread by controlling spoilage pathogens using lactobacillus fermentum c14 isolated from homemade curd. | one potent lactic acid bacterial strain c14 with strong antifungal activity was isolated from homemade curd. based on morphological as well as biochemical characters and 16s rdna sequence homology the strain was identified as lactobacillus fermentum. it displayed a wide antimicrobial spectrum against both gram-positive and gram-negative pathogenic bacteria, and also against number of food spoilage, plant and human pathogenic fungi. the cell free supernatant (cfs) of the strain c14 was also effec ... | 2017 | 28859156 |
| antifungal activity of gallic acid in vitro and in vivo. | gallic acid (ga) is a polyphenol natural compound found in many medicinal plant species, including pomegranate rind (punica granatum l.), and has been shown to have antiinflammatory and antibacterial properties. pomegranate rind is used to treat bacterial and fungal pathogens in uyghur and other systems of traditional medicine, but, surprisingly, the effects of ga on antifungal activity have not yet been reported. in this study, we aimed to investigate the inhibitory effects of ga on fungal stra ... | 2017 | 28524381 |
| prevalence, etiology, and risk factors of tinea pedis and tinea unguium in tunisia. | foot mycoses are a frequent disease that represents a public health problem worldwide. | 2017 | 28852411 |
| hemodialysis and kidney transplantation as predisposing conditions to onychomycosis. | onychomycosis (om) is one of the commonest superficial fungal infections. patients undergoing hemodialysis (hd) treatment and kidney transplant recipients (ktr) are considered at risk of contracting fungal infections, but the few published data do not reach the conclusion of whether they are predisposed to om. this study aimed to determine the prevalence and etiology of om in these patients and to determine the antifungal susceptibility profile of the isolated fungal species. | 2017 | 28609764 |
| production, characterization, and antifungal activity of a biosurfactant produced by rhodotorula babjevae ys3. | sophorolipids are one of the most promising glycolipid biosurfactants and have been successfully employed in bioremediation and various other industrial sectors. they have also been described to exhibit antimicrobial activity against different bacterial species. nevertheless, previous literature pertaining to the antifungal activity of sophorolipids are limited indicating the need for further research to explore novel strains with wide antimicrobial activity. a novel yeast strain, rhodotorula ba ... | 2017 | 28558761 |
| distribution of species of dermatophyte among patients at a dermatology centre of nghean province, vietnam, 2015-2016. | vietnam is a tropical country so fungal diseases including dermatophytosis may be prevalent, but epidemiological profiles of agents responsible for the infection have rarely been reported. | 2017 | 28831770 |
| diagnosis of dermatophytosis by conventional methods and comparatative analysis of sabouraud dextrose agar and dermatophyte test medium for isolation of dermatophytes. | dermatophytosis is a fungal disease which ranked as one of the most common cutaneous condition in all over the world. the aim of this cross sectional observational study is to identify the etiological agent of dermatophytosis and comparison of sabouraud dextrose agar (sda) and dermatophyte test medium (dtm) for the primary isolation of dermatophytes among the clinically suspected cases of dermatophytosis from the outpatient department of dermatology and venereology, mymensingh medical college ho ... | 2017 | 28588164 |
| the tetrazole vt-1161 is a potent inhibitor of trichophyton rubrum through its inhibition of t. rubrum cyp51. | prior to characterization of antifungal inhibitors that target cyp51, trichophyton rubrum cyp51 was expressed in escherichia coli, purified, and characterized. t. rubrum cyp51 bound lanosterol, obtusifoliol, and eburicol with similar affinities (dissociation constant [kd ] values, 22.7, 20.3, and 20.9 μm, respectively) but displayed substrate specificity, insofar as only eburicol was demethylated in cyp51 reconstitution assays (turnover number, 1.55 min(-1); km value, 2 μm). the investigational ... | 2017 | 28483956 |
| quantitative and structural analyses of the in vitro and ex vivo biofilm-forming ability of dermatophytes. | the aim of this study was to evaluate the in vitro and ex vivo biofilm-forming ability of dermatophytes on a nail fragment. | 2017 | 28708048 |
| common dermatophytes and in vitro anti-fungal susceptibility testing in patients attending the dermatological clinic at the hospital for tropical medicine, bangkok. | dermatophytes comprising the genera trichophyton, microsporum, and epidermophyton are important causes of superficial mycoses. the number of infected patients and the distribution of species of these organisms in our hospital were unknown. we therefore aimed to investigate the clinical pattern of dermatophyte infections and to identify the species of these dermatophytes at the dermatological clinic of the hospital for tropical medicine, faculty of tropical medicine, mahidol university, bangkok i ... | 2017 | 28513812 |
| performance of mycology and histopathology tests for the diagnosis of toenail onychomycosis due to filamentous fungi: dermatophyte and non-dermatophyte moulds. | improvement of laboratory diagnosis of onychomychosis is important so that adequate treatment can be safely implemented. to evaluate and compare the performance of mycological and histopathological examinations in onychomycoses caused by dermatophyte and non-dermatophyte moulds. patients with lateral/distal subungual onychomycosis in at least one hallux were enrolled in the protocol and assessed via mycological and histopathological tests. the isolation of filamentous fungi was considered the go ... | 2017 | 28504456 |
| the immunomodulatory effect of trichophyton rubrum exoantigens in the treatment of experimental septic arthritis. | understanding the nature and function of fungal exoantigens might lead to novel approaches in the treatment and prophylaxis of some infectious diseases. septic arthritis represents a serious problem for medicine due to the high incidence rate and severe complications. | 2017 | 28659996 |
| the survey of tinea capitis and scalp dermatophyte carriage in nursing home residents. | tinea capitis is a contagious dermatophyte infection of scalp and associated hairs. on the other hand, asymptomatic carriage is a status of positive dermatophyte scalp culture, but without signs or symptoms of tinea capitis, and no evidence of hair shaft invasion confirmed by direct microscopy. tinea capitis and asymptomatic carriage mostly occur in children, but adult females are becoming another population in recent decades. in this study, we focused on the prevalence and related fungi of tine ... | 2017 | 28525623 |
| the efficacy of fractional carbon dioxide (co2) laser combined with terbinafine hydrochloride 1% cream for the treatment of onychomycosis. | although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects and the efficacy of topical agents is not satisfying. currently, laser treatment has been studied for its efficacy in the treatment of onychomycosis. our study was aimed to evaluate the efficacy of fractional carbon dioxide (co2) laser treatment combined with terbinafine cream for 6 months in the treatment of onychomycosis and to analyze the influencing factors. | 2017 | 28557542 |
| the first succinylome profile of trichophyton rubrum reveals lysine succinylation on proteins involved in various key cellular processes. | dermatophytes, the most common cause of fungal infections, affect millions of individuals worldwide. they pose a major threat to public health because of the severity and longevity of infections caused by dermatophytes and their refractivity to therapy. trichophyton rubrum (t. rubrum), the most common dermatophyte species, is a promising model organism for dermatophyte research. post-translational modifications (ptms) have been shown to be essential for many biological processes, particularly in ... | 2017 | 28778155 |
| topical nitric oxide releasing nanoparticles are effective in a murine model of dermal trichophyton rubrum dermatophytosis. | systemic therapies are preferred for treating dermal dermatophytosis due to inadequate penetration of topical agents. however, systemic antifungals are associated with off-target effects and limited tissue penetration, and antimicrobial resistance is a growing concern. to address this, we investigated topical nitric oxide-releasing nanoparticles (no-np), which have been used against superficial fungal infections and bacterial abscesses. in addition to enhanced penetration and permeation conferre ... | 2017 | 28712918 |
| in vitro fungicidal effects of methylene blue at 625-nm. | the aim of the study is to confirm the effectiveness of photodynamic therapy (pdt) as a significant inhibitor of trichophyton rubrum (t. rubrum) and to determine the most appropriate dose and rate of delivery. trichophyton rubrum is the most common dermatophyte worldwide, responsible for the majority of superficial fungal infections. the traditional treatment of t. rubrum has known adverse effects. an alternative treatment is warranted. photosensitised t. rubrum specimens were treated with 625-n ... | 2017 | 28699222 |
| antifungal and ichthyotoxic sesquiterpenoids from santalum album heartwood. | in our continuing study on a survey of biologically active natural products from heartwood of santalum album (southwest indian origin), we newly found potent fish toxic activity of an n-hexane soluble extract upon primary screening using killifish (medaka) and characterized α-santalol and β-santalol as the active components. the toxicity (median tolerance limit (tlm) after 24 h at 1.9 ppm) of α-santalol was comparable with that of a positive control, inulavosin (tlm after 24 h at 1.3 ppm). these ... | 2017 | 28698478 |
| [effect of intense pulsed light on trichophyton rubrum growth in vitro]. | to investigate the inhibitory effect of 420 nm intense pulsed light on trichophyton rubrum growth in vitro and explore the mechanism. | 2017 | 28669966 |
| molecular strain typing of clinical isolates, trichophyton rubrum using non transcribed spacer (nts) region as a molecular marker. | dermatophytes are a group of fungi which infect keratinized tissues and causes superficial mycoses in humans and animals. the group comprises of three major genera, trichophyton, microsporum and epidermophyton. among them trichophyton rubrum is a predominant anthropophilic fungi which causes chronic infections. although, the infection is superficial and treatable, reinfection/coinfection causes inflation in the treatment cost. identifying the source and mode of transmission is essential to preve ... | 2017 | 28658757 |
| keratitis-ichthyosis-deafness syndrome accompanied by disseminated cutaneous fungal infection. | keratitis-ichthyosis-deafness (kid) syndrome is a rare genodermatosis. it is mostly associated with mutations of the connexin 26 gene, resulting in keratitis, erythrokeratoderma and neurosensory deafness. in addition to the clinical triad, the kid syndrome patients are at high risk for infectious complications, while the mechanisms are poorly understood. in the present article, we described an asian case of kid syndrome accompanied by fungal infection. the present study was designed to define th ... | 2017 | 28635012 |
| invasive trichophyton rubrum mimicking blastomycosis in a patient with solid organ transplant. | we present a case of tissue invasive trichophyton rubrum (t. rubrum) histologically mimicking blastomycosis in a patient with kidney transplant on chronic immunosuppression. invasive dermatophyte infections are rare, and present a diagnostic challenge to the dermatopathologist due to atypical clinical and histopathological presentations. | 2017 | 28627008 |
| terbinafine resistance conferred by multiple copies of the salicylate 1-monooxygenase gene in trichophyton rubrum. | resistance to antifungals is a leading concern in the treatment of human mycoses. we demonstrate that the sala gene, encoding salicylate 1-monooxygenase, is involved in resistance of the dermatophyte trichophyton rubrum to terbinafine, one of the most effective antifungal drugs against dermatophytes. a strain with multiple copies of sala was constructed and exhibited elevated expression of sala and increased terbinafine resistance. this reflects a mechanism not yet reported in a pathogenic fungu ... | 2017 | 28582544 |
| a giant dermatophyte abscess caused by trichophyton rubrum in an immunocompromised patient. | a 73-year-old male who had been receiving immunosuppressive drugs for 15 years developed a nodule on the left buttock region. the nodule slowly grew into a 15-cm fluctuant multilocular subcutaneous cyst. serum beta-d-glucan levels were high, and the yellow purulent fluid obtained from the cyst was positive for trichophyton rubrum. granuloma formation in the cyst wall and large abscesses in the central cystic area were found, and septated hyphae were observed in both tissues. the cyst was surgica ... | 2017 | 28566660 |
| production of trichophyton rubrum microspores in large quantities and its application to evaluate amorolfine/azole compound interactions in vitro. | trichophyton rubrum is the most frequently isolated dermatophyte species in european countries. the lack or poor sporulation of t. rubrum has always been a major complication and a limiting factor when performing antifungal susceptibility testing. therefore, we describe an in vitro method aiming to enhance sporulation of various t. rubrum isolates in order to perform antifungigrams. a combination of high co2 tensions and incubation on pda growth medium revealed to be optimal for sporulation of a ... | 2017 | 28480990 |