Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| ocular changes in a cat with disseminated blastomycosis. | a domestic shorthair cat examined because of dyspnea was found to have ophthalmoscopic and radiographic changes suggestive of systemic mycosis. the cat died despite antifungal therapy. histologic examination revealed blastomyces dermatitidis in the eyes, brain, lungs, stomach, liver, kidneys, spleen, pancreas, and adrenal glands. the pathologic changes were similar, but more widespread than those typically seen with canine blastomycosis. | 1985 | 4086373 |
| enhanced oxidative burst in immunologically activated but not elicited polymorphonuclear leukocytes correlates with fungicidal activity. | polymorphonuclear neutrophils (pmn) induced locally in immune mice by intraperitoneal injection of antigen exhibit enhanced fungicidal activity compared with pmn elicited with thioglycolate. the mechanism of the differences in these pmn populations was studied. sublethal infection was used to produce immunity to blastomyces dermatitidis. a correlation was sought between the ability of pmn to kill, or not kill, b. dermatitidis and the production of the oxidative burst, as measured by luminol-enha ... | 1985 | 3894234 |
| treatment of systemic mycoses with ketoconazole: in vitro susceptibilities of clinical isolates of systemic and pathogenic fungi to ketoconazole. | ketoconazole was tested in vitro in three different media against 69 isolates of pathogenic fungi by using a macro-broth dilution procedure. the dimorphic systemic pathogens were highly susceptible, with most isolates of blastomyces dermatitidis and histoplasma capsulatum being inhibited and killed by concentrations less than or equal to 0.39 micrograms of ketoconazole/ml. most isolates of coccidioides immitis were also inhibited or killed by 0.39 micrograms of ketoconazole/ml; however, several ... | 1985 | 3905985 |
| intracellular growth and phagocytosis of blastomyces dermatitidis by monocyte-derived macrophages from previously infected and normal subjects. | blastomyces dermatitidis evokes responses of human cellular immunity typical of other intracellular fungal pathogens. differences in growth rates of intracellular blastomyces yeast and the differences in amounts of yeast phagocytized by macrophages were determined for macrophages derived from peripheral blood monocytes from 11 persons with treated blastomycosis and 11 normal, healthy persons. cellular immunity was examined by lymphocyte uptake of [3h]thymidine in response to a specific antigen o ... | 1985 | 3965594 |
| in-vitro studies with sf 86-327, a new orally active allylamine derivative. | sf 86-327 (sandoz forschungsinstitut) is an orally active allylamine derivative related to naftifine. the antifungal activity of sf 86-327 was compared in vitro with those of naftifine, ketoconazole, and itraconazole (r 51,211, janssen pharmaceutica) by agar dilution. 120 fungal isolates were tested. also, the antifungal activities of sf 86-327 and naftifine against 18 dimorphic pathogens were assayed in vitro by broth dilution. results of these studies support claims that sf 86-327 is a broad s ... | 1985 | 2990057 |
| characteristics of the pulmonary cellular immune response to two strains of blastomyces dermatitidis in the mouse. | in order to assess the cellular responses in the lung in murine pulmonary blastomycosis, serial lung lavages were performed in normal balb/cbyj mice that had received an intranasal inoculation with 1 of 2 strains of blastomyces dermatitidis of opposite virulence. the virulent strain, atcc 26199, induced an increasing number of neutrophils recovered from the lung lavages. an early peak of incoming neutrophils was seen at 1 to 2 days, followed by a more rapid accumulation of intraalveolar neutroph ... | 1985 | 2416256 |
| comparison of the enzyme immunoassay, immunodiffusion, and complement fixation tests in detecting antibody in human serum to the a antigen of blastomyces dermatitidis. | using a new enzyme immunoassay (eia) and standard immunodiffusion (id) and complement fixation techniques for antibody to the a antigen of blastomyces dermatitidis, we tested serum from 27 patients with blastomycosis diagnosed histopathologically or by culture; 20 with diagnoses made during 1981 through 1983 (group a) and 7 during 1974 through 1976 (group b). we also studied 30 control subjects with mycoplasma pneumoniae infection (17 subjects), histoplasmosis (6 subjects), coccidioidomycosis (1 ... | 1986 | 3079974 |
| grouping of aspergillus species with exoantigens. | ninety-two slant extracts prepared from 2-week-old cultures of seven aspergillus groups, nonsporulating "albino-type" a.fumigatus, blastomyces dermatitidis, histoplasma capsulatum, 3 penicillium spp., 2 pseudallescheria spp., 3 paecilomyces spp., and acremonium sp., were analyzed concurrently against antisera to a. fumigatus, a. flavus, a. nidulans, a. niger, and a. terreus. the extract of each of the aforementioned five pathogenic aspergillus spp. produced 2-11 specific antigen-antibody complex ... | 1986 | 3086014 |
| an overview of macrophage-fungal interactions. | a review of the literature (148 references) on the interactions of fungi with polymorphonuclear cells, monocytes and macrophages is presented. the interactions of aspergillus species, coccidioides immitis, blastomyces dermatitidis, histoplasma capsulatum, cryptococcus neoformans, candida albicans, and candida species with human and experimental animal derived immune cells are examined in this overview. an effort has been made to present the reader with a comprehensive list of references with the ... | 1986 | 3520327 |
| development and characterization of histoplasma capsulatum-reactive murine t-cell lines and clones. | experimental studies have suggested that antigen-specific t lymphocytes are important mediators of resistance to infection with the pathogenic fungus histoplasma capsulation. to gain a better understanding of the role of t lymphocytes, we developed murine t-cell lines and clones that recognized histoplasma antigens. these t cells were of the helper/inducer phenotype (thy-1.2+ lyt-1+ l3t4+ lyt-2-) and exerted multiple immunological functions. t-cell lines and 12 clones proliferated vigorously in ... | 1986 | 2430887 |
| splenic abscess caused by blastomyces dermatitidis. | we have reported a case of fungal splenic abscess caused by blastomyces dermatitidis. splenic abscess is an uncommon disorder, and fungus as the causative organism is rare. the diagnosis of splenic abscess can be rapidly made with radionuclide and ct scanning and ultrasonography. splenectomy with appropriate antifungal chemotherapy is the currently recommended therapy. | 1986 | 3715545 |
| monoclonal antibodies against the m-protein and carbohydrate antigens of histoplasmin characterized by the enzyme-linked immunoelectrotransfer blot method. | monoclonal antibodies (mabs) of two different specificities were produced by immunizing mice with the semipurified m antigen of histoplasmin. one type, from clone cb4, was an immunoglobulin m that precipitated a polysaccharide present in histoplasmin and also formed immunoprecipitates with a cross-reactive polysaccharide present in extracts of blastomyces dermatitidis and coccidioides immitis. the second type of mab, from clone ec2, was an immunoglobulin g that reacted in the enzyme-linked immun ... | 1986 | 3017863 |
| evaluation of cross-reactions in histoplasma capsulatum serologic tests. | cross-reactivity in histoplasma serologic tests was evaluated by using sera from patients with histoplasmosis and other infections. serum samples from 127 of 134 (95%) patients with histoplasmosis were judged positive by complement fixation tests, and 121 (90%) showed h bands, m bands, or both by immunodiffusion. of these 134 patients, cross-reactions were seen to blastomyces dermatitidis in 53 patients (40%), to coccidioides immitis in 20 patients (16%), and to aspergillus fumigatus in 3 patien ... | 1986 | 2420821 |
| fungicidal activity of murine inflammatory polymorphonuclear neutrophils: comparison with murine peripheral blood pmn. | a characteristic of inflammation is the influx of polymorphonuclear neutrophils (pmn) from peripheral blood to the inflammatory reaction. we report on metabolic alterations and alterations in fungicidal activity in pmn elicited intraperitoneally with different inflammatory agents. the fungicidal activity of murine peripheral blood pmn (pb-pmn) against phagocytosable candida albicans and nonphagocytosable blastomyces dermatitidis was compared to that of murine inflammatory pmn. pmn elicited with ... | 1986 | 3552339 |
| comparative activities of uk-49,858 and amphotericin b against blastomyces dermatitidis infections in mice. | uk-49,858, a new antifungal triazole derivative, was compared with amphotericin b in the treatment of pulmonary infections by blastomyces dermatitidis in male balb/cbyj mice. administration of uk-49,858 in daily doses of 25 or 50 mg/kg for 21 days gave 30 and 100% survival rates, respectively. these results compared with 100% mortality in infected controls and 100% survival among mice treated with amphotericin b. uk-49,858 did not eradicate the fungus from the lungs of surviving animals, while a ... | 1986 | 3015001 |
| isolation of blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in wisconsin. | in investigating six cases of blastomycosis in two school groups that had separately visited an environmental camp in northern wisconsin in june 1984, we identified a large outbreak of the disease and isolated blastomyces dermatitidis from soil at a beaver pond near the camp. of 89 elementary-school children and 10 adults from the two groups, 48 (51 percent) of the 95 evaluated in september had blastomycosis. of the cases, 26 (54 percent) were symptomatic (the median incubation period was 45 day ... | 1986 | 3945290 |
| fungicidal activity of murine broncho-alveolar macrophages against blastomyces dermatitidis. | the fungicidal activity of murine broncho-alveolar macrophages (bam) against the yeast form of a virulent strain of blastomyces dermatitidis was studied in the small-volume wells of a terasaki plate. in a 4-h fungicidal assay, significant killing (16-33%) of the fungus by unstimulated bam was demonstrated with bam from normal mice and from mice rendered immune to lethal infection with b. dermatitidis. no significant differences between the activity of bam from these two sources could be identifi ... | 1986 | 3950963 |
| isolation of blastomyces dermatitidis from an earthen floor in southwestern ontario, canada. | the first canadian isolation of blastomyces dermatitidis from nature is recorded. this was from the earthern floor of a petroleum filtering shed located in southwestern ontario. a technician working in this environment became infected and was diagnosed as having systemic blastomycosis with meningeal involvement. | 1986 | 3771778 |
| immunodiagnosis of blastomycosis. | the diagnosis of blastomycosis has long been a challenge for the clinician. primarily a pulmonary disease, blastomycosis is difficult to differentiate from other respiratory infections by clinical symptoms alone. substantial improvement in the diagnosis of blastomycosis can be attributed to the availability of the purified a antigen of blastomyces dermatitidis and its homologous antibody and the incorporation of these reagents into diagnostic tests. reliable procedures for accurately and rapidly ... | 1986 | 3317596 |
| epidemiologic aspects of blastomycosis, the enigmatic systemic mycosis. | a growing body of epidemiologic information derives from the study of sporadic cases and seven epidemics of blastomycosis, although a complete epidemiologic description of the disease is impeded by the absence of a skin test and difficulty isolating the causative fungus, blastomyces dermatitidis, from nature. most cases occur sporadically in humans and dogs in a worldwide distribution. endemic areas in the united states include southeastern, southcentral, and midwestern states, particularly arka ... | 1986 | 3317597 |
| blastomycotic meningitis. | a difficult and tragic case of central nervous system blastomycosis is presented as the basis for a review of the diagnostic criteria required to establish this diagnosis and to present a scheme for the diagnosis and therapy of chronic meningitis. the diagnosis in our case was complicated by preexisting inadequately treated tuberculosis; a prepontine mass; and a cervical intradural, extramedullary, circumferential mass. this exceptional case of chronic basilar meningitis with cervical myelopathy ... | 1986 | 3726746 |
| survival of blastomyces dermatitidis in the gastrointestinal tract of an orally infected insectivorous bat, rhinopoma hardwickei hardwickei gray. | the survival of blastomyces dermatitidis with markedly reduced population, in the gastrointestinal tract and faeces of rhinopoma hardwickei orally infected with 2.5 x 10(5) colony forming units of the fungus, is reported. b. dermatitidis was cultured from the stomach, intestine and faeces up to 16-24 h and from rectum up to 48 h post infection. the results demonstrate that orally infected r. hardwickei hardwickei bats transiently shed b. dermatitidis through their faeces but the significance of ... | 1986 | 3746588 |
| medium for susceptibility testing and yeast phase conversion of blastomyces dermatitidis. | cottonseed protein agar and a modified tween-albumin casein hydrolysate (tac) medium were compared for the yeast phase conversion of blastomyces dermatitidis strains including fresh isolates as well as strains maintained in long-term storage. it was found that both media converted all the b. dermatitidis (mycelial phase) strains studied to yeast phase in three days. the tac medium has the added advantage that it is clear and the growth can be recognized earlier than in the opaque cottonseed agar ... | 1986 | 3762656 |
| intracerebellar blastomycosis abscess in an african man. | the case of a solitary cerebellar abscess in a 36-year-old rwandese male is described. first it was considered to be tuberculosis, but at microscopal examination of the lesion after neurosurgical excision the true germ was found: blastomyces dermatitidis. this solitary intracerebellar blastomycosis abscess is only the fifth case reported worldwide and the first in african medical annals. | 1986 | 3780110 |
| reliability of exoantigens for differentiating blastomyces dermatitidis and histoplasma capsulatum from chrysosporium and geomyces species. | a recent study suggested that chrysosporium species have the same diagnostic antigens as histoplasma capsulatum and blastomyces dermatitidis and, thus, compromise the antigenic identification of these pathogens. in light of these findings, studies were undertaken to determine the reliability of the exoantigen tests for identifying b. dermatitidis and h. capsulatum organisms from cultures. sixty-three slant or shake culture extracts, or both, were derived from c. asperatum, c. keratinophilum, c. ... | 1986 | 3956141 |
| blastomycosis of the eyelid. | an 84-year-old man had a verrucous lesion of the left lower eyelid that caused progressive ectropion. cultures of the lesion taken at the time of surgical excision demonstrated blastomyces dermatitidis. histologically, the excised tissue demonstrated pseudoepitheliomatous hyperplasia, a characteristic change of cutaneous blastomycosis. | 1986 | 3942552 |
| canine blastomycosis in southern saskatchewan. | the incidence of canine blastomycosis in southern saskatchewan is examined and three clinical cases are described. nineteen cases of the disease have been diagnosed in southern saskatchewan since april of 1981. eight cases were diagnosed during a six month period from august 1985 to february 1986 in dogs residing in a small central area of regina. the geographical and chronological clustering of cases suggests a local source of exposure to blastomyces dermatitidis, not previously considered to b ... | 1986 | 17422705 |
| chronic murine pulmonary blastomycosis induced by intratracheally inoculated blastomyces dermatitidis conidia. | groups of 6-wk-old male balb/cbyj mice were injected intratracheally (it) with viable conidia from blastomyces dermatitidis strains (fw or cr) harvested from 2-wk-old cultures (pine-drouhet agar at 30 degrees c) and separated from hyphal elements by polycarbonate filtration (5 micron). inocula (0.05 ml) were 93 to 97% conidia in nonpyrogenic normal saline (npns) with greater than 90% viability. quantitative cultures of the lungs and trachea of mice killed immediately after injection of 10(4) con ... | 1987 | 3800145 |
| mycelial- to yeast-phase transitions of the dimorphic fungi blastomyces dermatitidis and paracoccidioides brasiliensis. | the physiological changes that occur during the mycelial- to yeast-phase transitions induced by a temperature shift from 25 to 37 degrees c of cultures of blastomyces dermatitidis and paracoccidioides brasiliensis can be divided into three stages. the triggering event is a heat-related insult induced by the temperature shift which results in partial uncoupling of oxidative phosphorylation and declines in cellular atp levels, respiration rates, and concentrations of electron transport components ... | 1987 | 3624202 |
| use of a urease-antibody conjugate in an enzyme immunoassay for the detection of blastomycosis. | a urease-antibody conjugate was used in an enzyme-linked immunoassay (elisa) for the detection of antibodies in blastomycosis. a blastomyces dermatitidis immunodiffusion antigen was used as the reference antigen in a solid phase indirect elisa procedure and the endpoints were determined visually. urease elisa results on serum specimens from patients with blastomycosis compared favorably (90%) with results obtained spectrophotometrically by the alkaline phosphatase enzyme system. specificity was ... | 1987 | 3668759 |
| development of a comparative dot elisa for the detection of antibodies in blastomycosis. | we present a preliminary study utilizing an enzyme immunoassay for the detection of antibodies in blastomycosis using nitrocellulose membrane as the solid support. the comparative dot enzyme-linked immunosorbent assay (cde) utilizing blastomyces dermatitidis, histoplasma capsulatum, and coccidioides immitis antigens allows rapid screening of specimens and determination of a serum profile with respect to anti-blastomyces antibodies. sensitivity (76% or greater) and specificity (approximately 12% ... | 1987 | 3691032 |
| severe uterine hemorrhage from blastomycosis of the endometrium. a case report. | a 32-year-old black woman presented in the emergency room with vaginal bleeding. physical examination revealed a granulomatous lesion on the thigh and a breast abscess. histopathologic examination and culture of an endometrial biopsy revealed blastomyces dermatitidis. the breast abscess and thigh lesion were found to contain b. dermatitidis as well. | 1987 | 3572911 |
| effect of a local immune reaction on peripheral blood polymorphonuclear neutrophil microbicidal function: studies with fungal targets. | peripheral blood polymorphonuclear neutrophils (pmn) from mice immunized with blastomyces dermatitidis and then stimulated locally (intraperitoneally, ip) with b. dermatitidis antigen had enhanced killing of b. dermatitidis in vitro (54.4 +/- 19.49 of inoculum) compared to nonimmune mice (32.7 +/- 8.7%; p less than 0.02), nonimmune mice given antigen ip (30.6 +/- 14.0%; p less than 0.05), or immune mice not given antigen ip (15.4 +/- 9.9%; p less than 0.01). peripheral blood pmn from all four gr ... | 1987 | 2960460 |
| growth inhibition of blastomyces dermatitidis in alveolar and peripheral macrophages from patients with blastomycosis. | blastomyces dermatitidis evokes a pyogranulomatous disorder with organisms frequently found inside giant cells. macrophages from bronchoalveolar lavage fluid and peripheral blood in monolayer cell cultures were challenged with live yeast organisms to examine phagocytosis and intracellular growth. a greater number of macrophages from patients recovering from blastomycosis had phagocytized blastomyces compared with macrophages from healthy control donors. no differences were detected within the gr ... | 1987 | 3813204 |
| disseminated blastomyces dermatitidis infection in a non-endemic area. a case report. | in areas where tuberculosis is endemic other causes of respiratory infection are often overlooked. a pulmonary infiltrate associated with skin lesions without a microbiological diagnosis of tuberculosis should arouse suspicion of a fungal infection. this was demonstrated in a patient in whom blastomyces dermatitidis, a rare pathogen in southern africa, was isolated. | 1987 | 3589869 |
| cutaneous blastomycosis as a complication of transthoracic needle aspiration. | a patient with an ill defined density in the left upper lobe underwent transthoracic needle aspiration. a diagnosis of blastomyces dermatitidis was made from the aspiration. the patient later returned with a cutaneous ulcer at the site of needle aspiration. b dermatitidis was subsequently recovered from the skin lesion. | 1987 | 3581941 |
| activation of pulmonary macrophages for fungicidal activity by gamma-interferon or lymphokines. | the ability of murine recombinant gamma interferon (ifn) or lymphokines to enhance the fungicidal activity of murine pulmonary macrophages (pum) was studied in in vitro. pum monolayers were incubated overnight with ifn, lymph node cells (lnc) plus concanavalin a, supernatants from con a stimulated lnc or spleen cell cultures (con a sup), or tissue culture medium (tcm) +/- con a (5 micrograms/ml) or +/- lipopolysaccharide (lps, 10 ng to 10 micrograms/ml). after treatment, culture fluids were remo ... | 1987 | 3124995 |
| two outbreaks of blastomycosis along rivers in wisconsin. isolation of blastomyces dermatitidis from riverbank soil and evidence of its transmission along waterways. | blastomycosis cannot yet be prevented or controlled, in part because the natural habitat of the causative fungus, blastomyces dermatitidis, remains ill defined. in investigating 2 outbreaks of blastomycosis that occurred in the summer of 1985 among persons engaged in activities along rivers in contiguous central wisconsin counties, we isolated b. dermatitidis from soil at one of the riverbanks. blastomycosis developed in 7 (58%) of 12 residents and guests who had gathered at a pheasant farm on t ... | 1987 | 3688635 |
| recovery of blastomyces dermatitidis from blood of a patient with disseminated blastomycosis. | this report describes the first well-documented reported case of the recovery of blastomyces dermatitidis from the blood of a patient with disseminated blastomycosis. the isolate was recovered by using a lysis-centrifugation method and inhibitory mold agar after 6 days of incubation at 30 degrees c. one of six blood samples collected yielded a positive culture. | 1987 | 3624440 |
| survival and growth of ajellomyces (blastomyces) dermatitidis on oak leaves coated with saliva. | yeast-form cells of ajellomyces dermatitidis transferred to unsterilized and sterilized oak leaves in a humidity chamber failed to grow and produce mycelium. transfers of these cells to mycobiotic agar resulted in the growth of a. dermatitidis from all 5 autoclaved and 4 of the 11 unsterilized leaves. soaking oak leaves with human airways secretions or saliva and inoculating them with yeast-form cells, and pouring sterile h2o on the leaves 10 days to 2 months later, permitted growth on 11 out of ... | 1987 | 3627223 |
| serological tests for blastomycosis: assessments during a large point-source outbreak in wisconsin. | enzyme immunoassay (eia), immunodiffusion (id), and complement fixation (cf) tests for antibody to the a antigen of blastomyces dermatitidis were assessed in 47 patients in an epidemic of blastomycosis and in 89 control subjects with lower respiratory tract illness. antibody was detected by eia, id, and cf in 77%, 28%, and 9% of the patients, respectively. eia titers ranged from 1:8-1:512 (median titer, 1:128). antibody detected by id or cf was always detectable by eia. antibody was detected by ... | 1987 | 3100658 |
| activation of murine polymorphonuclear neutrophils for fungicidal activity by recombinant gamma interferon. | recombinant murine gamma-interferon (ifn) was tested for its ability to enhance murine polymorphonuclear neutrophil (pmn) fungicidal activity in vitro. pmns, elicited by intraperitoneal injection of thioglycollate 4 hr prior to collection, were treated with 0.00003-300,000 units of ifn per milliliter for 1 hr prior to challenge with yeast form blastomyces dermatitidis. these pmns were not fungicidal for blastomyces in the absence of ifn; significant enhancement of pmn fungicidal activity by ifn ... | 1987 | 3106548 |
| fungicidal mechanisms of activated macrophages: evidence for nonoxidative mechanisms for killing of blastomyces dermatitidis. | the mechanism(s) by which lymphokine-activated peritoneal macrophages kill blastomyces dermatitidis was studied. resident peritoneal macrophages from balb/cbyj mice, when treated overnight with lymph node cells plus concanavalin a, supernatants from concanavalin a-stimulated spleen cells, or recombinant gamma interferon, were then able to kill a virulent b. dermatitidis isolate (atcc 26199) (at levels of 25% +/- 4%, 28% +/- 8%, and 21% +/- 5%, respectively). killing was not significantly decreas ... | 1987 | 3316037 |
| fungal-strain-dependent alterations in the time course and mortality of chronic murine pulmonary blastomycosis. | intratracheal injection of 10(4) conidia of blastomyces dermatitidis strain m1-a into mice was shown in previous work to induce chronic pulmonary and disseminated infection with histopathologic features of chronic human blastomycosis. furthermore, 10-fold variations in inoculum density produced marked changes in mean survival times (msts), i.e., 32 days at 10(6), 36 days at 10(5), 97 days at 10(4), and 172 days at 10(3). a second strain (m1-b) failed to induce death in this model. to assess fung ... | 1988 | 3335407 |
| blastomycosis presenting as polyarticular septic arthritis. | articular infection with blastomyces dermatitidis frequently is difficult to diagnose as it resembles bacterial arthritis in several ways. this report of an elderly man who had initially monoarticular and eventually polyarticular arthritis illustrates the clinical and laboratory findings that should suggest blastomycosis. treatment with amphotericin b and ketoconazole in sequence led to complete resolution of the infection. | 1988 | 3199404 |
| enzyme immunoassay detection of antibodies in north american blastomycosis: comparison of three blastomyces dermatitidis antigens. | 1988 | 3200261 | |
| experimental blastomycosis pneumonia in mice by infection with conidia. | we describe a murine model of acute blastomycosis pneumonia induced by blastomyces dermatitidis conidia. anesthetized mice were infected by placing a droplet containing conidia suspended in sterile saline on the nares and allowing the suspension to be aspirated into the lungs. conidia were obtained from mycelia derived from the yeast forms of two well characterized strains of b. dermatitidis, atcc 26199 and 26197. atcc 26199 yeast and conidia were highly virulent in balb/cbyj mice whereas both f ... | 1988 | 3246623 |
| failure of ketoconazole treatment of blastomyces dermatitidis [corrected] due to interaction of isoniazid and rifampin. | 1988 | 3190036 | |
| systemic fungal infections: diagnosis and treatment. i. sporotrichosis. | sporotrichosis is a fungal infection caused by the dimorphic fungus sporothrix schenckii. although this fungal microorganism is labeled a true pathogen, its virulence is less than that of other fungal pathogens, such as coccidioides immitis, histoplasma capsulatum, and blastomyces dermatitidis. this article discusses its clinical manifestations, experimental models, diagnosis, and therapy. | 1988 | 3062093 |
| in vitro interactions between blastomyces dermatitidis and other zoopathogenic fungi. | the results of in vitro interactions between colonies of blastomyces dermatitidis and six other zoopathogenic fungi are reported. the interactions were found to range from neutral with histoplasma capsulatum and candida albicans to strongly antagonistic with microsporum gypseum, pseudallescheria boydii, and sporothrix schenckii, and including lysis by cryptococcus neoformans. these observations suggest that interactions between zoopathogenic fungi may be one of the biotic factors likely to influ ... | 1988 | 3058276 |
| enhanced oxidative mechanisms in immunologically activated versus elicited polymorphonuclear neutrophils: correlations with fungicidal activity. | peritoneal polymorphonuclear neutrophils (pmn) from mice were tested for their ability to kill the yeast form of blastomyces dermatitidis (bd) in vitro and for their fungicidal mechanisms. pmn elicited from immune mice by the intraperitoneal injection of non-viable bd (referred to as immunologically activated pmn or actpmn) showed significantly enhanced fungicidal activity in comparison with pmn elicited with thioglycollate medium (thiopmn) [means = 44.7% (sd 12.8%) and 16.4% (sd 9.2%) killed; n ... | 1988 | 2828626 |
| preparation and elisa evaluation of blastomyces dermatitidis yeast phase lysate antigens. | enzyme-linked immunosorbent assay (elisa) comparative studies are described in which 10 blastomyces dermatitidis antigenic preparations from human, dog, and soil strains were used for the detection of rabbit serum antibodies directed against b. dermatitidis killed yeast cells of human and dog origin as well as detection of antibodies in human serum samples. reactive reagents were produced from all 10 strains, but two antigens (k-le and t-043324) demonstrated exceptional sensitivity with moderate ... | 1988 | 3229098 |
| latent disseminated blastomycosis with choroidal involvement. | a 36-year-old man developed blurred vision and a cough five months after traveling to an area from where a large outbreak of acute blastomycosis had been reported. examination revealed a left choroidal lesion in the macular region, skin lesions on the right calf, and a left lung apical infiltrate. histopathologic examination of the skin lesion demonstrated a granulomatous inflammation and broad based, budding yeast characteristic of blastomyces dermatitidis. amphotericin b therapy produced a rap ... | 1988 | 3355423 |
| in vivo and in vitro activation of pulmonary macrophages by ifn-gamma for enhanced killing of paracoccidioides brasiliensis or blastomyces dermatitidis. | the fungicidal capacity of murine pulmonary macrophages (pum) activated in vitro with ifn or lymphokines or in vivo with ifn was studied. pum treated overnight with ifn (1000 u/ml), con a-stimulated spleen cell culture supernatants, or lymph node cells plus con a significantly killed yeast cells of the gar w isolate of paracoccidioides brasiliensis 45.5 +/- 2.1%, 72.0 +/- 4.2%, and 51.5 +/- 0.7% respectively. two other isolates of p. brasiliensis (ru and la) were also killed (45 and 34%) by pum ... | 1988 | 3128610 |
| in vitro conversion of african isolates of blastomyces dermatitidis to their yeast form. | 1988 | 3059184 | |
| characterization of murine bronchoalveolar macrophage respiratory burst: comparison of soluble and particulate stimuli. | stimulation of the respiratory burst of murine bronchoalveolar macrophages obtained by lung lavage was studied using four different stimuli and different assay conditions. one soluble stimulus, phorbol myristate acetate (pma), two intracellular particles, zymosan and blastomyces dermatitidis conida, and one extracellular particle, b. dermatitidis yeast, were incubated with either freshly obtained macrophages in suspension or 2- and 48-hour macrophage monolayers. suspension cultures were incubate ... | 1988 | 2848085 |
| systemic fungal infections: diagnosis and treatment. i. blastomycosis. | blastomycosis is a rare systemic fungal infection caused by blastomyces dermatitidis, which is often difficult to diagnose because of its spectrum of manifestations, varying severity, and unusual occurrence in most geographic areas. because routine serologic methods and skin tests are not reliable for this pathogen, diagnosis is made by visualization of the organism in tissue, sputum, or exudate, or by culture. once blastomycosis is diagnosed, therapeutic options include treatment with amphoteri ... | 1988 | 3062092 |
| arterial thromboembolic disease in a dog with blastomycosis localized in a hilar lymph node. | an 8-year-old mixed-breed dog was evaluated for caudal paresis. transient lameness of the left hind and left forelimbs had developed during the preceding week. clinical findings included conscious proprioceptive deficits, hyporeflexive tendon reflexes and decreased pain perception, coolness in the hind limbs and left forelimb, and absence of femoral pulses. a fluid-dense mass was radiographically identified adjacent to the left atrium. echocardiography revealed a mass in the left atrium and spon ... | 1988 | 3192466 |
| immunoidentification of histoplasma capsulatum and blastomyces dermatitidis with commercial exoantigen reagents. effect of culture age. | we have studied the effect of the length of incubation on the reliability of commercial exoantigen test reagents (nolan/scott biological laboratories inc, and immuno-mycologics inc). antigen extracts, tested in each commercial system, were prepared from duplicate sets of cultures of histoplasma capsulatum (12 isolates) and of blastomyces dermatitidis (11 isolates) after one to six weeks of growth. for isolates of h capsulatum, antigens necessary for immunoidentification were detected in most cul ... | 1988 | 3358653 |
| community-acquired fungal pneumonias. | histoplasma capsulatum, coccidioides immitis, blastomyces dermatitidis, and cryptococcus neoformans can cause acute community-acquired pneumonia. all are soil-dwelling fungi and disturbance of contaminated soil is necessary for infection in man. each has particular epidemiologic considerations that may offer a clue to diagnosis, but the clinical presentation is not sufficiently characteristic to be of diagnostic help. infection may produce variable symptoms, ranging from asymptomatic skin test c ... | 1989 | 2652235 |
| blastomyces dermatitidis infections in the rsa. | twenty cases of blastomycosis have been confirmed in the rsa, 9 of which are presented for the first time. patients came from all four provinces and the mean age was 40 years. six cases were diagnosed between 1985 and 1987. differences between strains of blastomyces dermatitidis isolated in the rsa and in north america include morphological and cultural characteristics, mycelial-yeast conversion, antigenic structure, and compatibility in cross-mating experiments. the diagnosis of this disease ca ... | 1989 | 2662433 |
| in vivo activation of peripheral blood polymorphonuclear neutrophils by gamma interferon results in enhanced fungal killing. | the effect of in vivo administration of murine recombinant gamma interferon (ifn) on the fungicidal activity of murine peripheral blood polymorphonuclear neutrophils (pb-pmns) was studied. mice were injected intramuscularly with 250, 2,500, 25,000 or 250,000 u of ifn 5 h before collection of peripheral blood. purified pb-pmns were cocultured in vitro with blastomyces dermatitidis yeast cells for 2 h. pb-pmns from untreated mice killed 44.5 +/- 12.5% of the fungal inoculum, whereas pb-pmns from m ... | 1989 | 2550367 |
| concurrent pulmonary blastomyces dermatitidis and mycobacterium tuberculosis infection in an hiv-1 seropositive man. | 1989 | 2509572 | |
| production and characterization of murine monoclonal antibodies to histoplasma capsulatum yeast cell antigens. | four monoclonal antibodies (mabs) were produced by immunizing mice with a disrupted yeast cell homogenate of histoplasma capsulatum. mabs 1 and 2 reacted only with the yeast cell antigens of h. capsulatum and blastomyces dermatitidis, whereas mabs 3 and 4 showed broader cross-reactivity. mab 3 cross-reacted with b. dermatitidis, paracoccidioides brasiliensis, sporothrix schenckii, and candida albicans, and mab 4 cross-reacted with b. dermatitidis, c. albicans, coccidioides immitis, aspergillus f ... | 1989 | 2917790 |
| blastomycosis. | blastomycosis is an uncommon, sometimes self-healing, sometimes fatal, infectious disease caused by the fungus blastomyces dermatitidis. although amphotericin b is still considered the drug of choice, ketoconazole and several other imidazole drugs--miconazole, itraconazole, econazole--have shown promise in the treatment of blastomycosis. | 1989 | 2670369 |
| blastomycosis in africa. a review of known cases diagnosed between 1951 and 1987. | the known african cases of blastomycosis to 1987 are presented, including thirteen previously undescribed cases. this brings to 81 the total number of cases known to have occurred in africa. the question of whether the disease in africa is the same in all respects as that in north america is addressed; the age and sex distributions of patients are similar. minor differences in the clinical features relate particularly to the type of skin lesion, the more frequent bone involvement and the less fr ... | 1989 | 2682252 |
| cholangitis due to blastomyces dermatitidis. | a 70-yr-old woman presented with nonspecific complaints and had findings of a cholestatic liver enzyme pattern and a dilated left intrahepatic ductal system by radiographic imaging. endoscopic retrograde cholangiopancreatography revealed multiple irregular flat stones and a fixed filling defect of the left hepatic duct. at the time of surgery a stonelike lesion of this ductal orifice was found along with a miliary pattern of infection of the left liver lobe. histologic and microbiologic studies ... | 1989 | 2703118 |
| case 49-1988: histoplasma capsulatum or blastomyces dermatitidis? | 1989 | 2725627 | |
| unexpected recovery of blastomyces dermatitidis from an anaerobic pleural empyema. | 1989 | 2729345 | |
| activity of ici 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis. | ici 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. no other previously tested azole has shown similar activity. fungicidal activity against blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses. | 1989 | 2729949 |
| blastomycosis in washington parish, louisiana, 1976-1985. | for the period 1976-1985, the authors attempted to identify all cases of blastomycosis in louisiana and studied in detail one county (washington parish) suspected by local physicians of having an unusually high incidence of the disease. the mean annual incidence rates for louisiana and for washington parish were 0.23 and 6.8 cases per 100,000 population, respectively. to the authors' knowledge, the rate for washington parish is the highest annual incidence rate documented for a population in a n ... | 1989 | 2787106 |
| divergent patterns of pulmonary blastomycosis induced by conidia and yeasts in athymic and euthymic mice. | athymic nude (nu/nu) mice are uniformly more susceptible than euthymic nu/+ mice to lethal infection with intranasally inoculated blastomyces dermatitidis, whether infection is initiated by yeasts or conidia. conidial infection requires a high inoculum size; the disease produced is prolonged and disseminated. yeasts are infective at a low inoculum size and produce a rapidly fatal pneumonia. thymus transplantation is more protective for conidia-infected than yeast-infected nude mice, presumably b ... | 1989 | 2526607 |
| dna probe for the identification of histoplasma capsulatum. | a 1.85-kilobase hindiii nuclear dna probe from histoplasma capsulatum g217b detected polymorphic restriction fragments within whole-cell dna from different clinical isolates of h. capsulatum, consistent with the previous system of classification. the probe failed to hybridize to dna from blastomyces dermatitidis, candida spp., saccharomyces cerevisiae, sepedonium chrysospermum, and chrysosporium keratinophilum under low-stringency conditions and therefore may have value as a diagnostic reagent t ... | 1989 | 2573616 |
| dimorphism in histoplasma capsulatum: a model for the study of cell differentiation in pathogenic fungi. | several fungi can assume either a filamentous or a unicellular morphology in response to changes in environmental conditions. this process, known as dimorphism, is a characteristic of several pathogenic fungi, e.g., histoplasma capsulatum, blastomyces dermatitidis, and paracoccidioides brasiliensis, and appears to be directly related to adaptation from a saprobic to a parasitic existence. h. capsulatum is the most extensively studied of the dimorphic fungi, with a parasitic phase consisting of y ... | 1989 | 2666842 |
| correlative studies of blastogenic responses and interleukin 1 production by mononuclear cells from patients with zoopathogenic fungal infections. | the production of interleukin 1 (il 1) by adherent peripheral blood mononuclear cells (pbmc) was quantitated in 16 individuals infected with histoplasma capsulatum or blastomyces dermatitidis and 16 age-matched controls. in parallel, we measured blastogenic responses to phytohemagglutinin (pha) by pbmc from patients and controls. of the 16 patients, six had pulmonary histoplasmosis, six had disseminated histoplasmosis, two had pulmonary blastomycosis, and two had disseminated blastomycosis. at t ... | 1989 | 2789278 |
| enhanced killing of blastomyces dermatitidis by gamma interferon-activated murine peripheral blood polymorphonuclear neutrophils. | normal peripheral blood polymorphonuclear neutrophils (pb-pmns), challenged in vitro with yeast form blastomyces dermatitidis, reduced inoculum colony-forming units of a virulent strain by 37.5 +/- 9.5%. pre-incubation of pb-pmns with 10-100,000 u/ml of purified recombinant murine gamma-interferon (ifn) for 1 h prior to challenge with fungi resulted in significant enhancement of pb-pmn fungicidal activity. no direct fungicidal activity by ifn alone was observed. pretreatment of selected concentr ... | 1989 | 2515161 |
| evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens. | cilofungin (ly121019) is a new lipopeptide antifungal drug. we tested this drug against 141 pathogenic fungal isolates. all fungal species were tested by broth dilution at 35 degrees c. malassezia furfur was tested by agar dilution. the results demonstrate the specificity of cilofungin activity. candida albicans, candida tropicalis, and malassezia pachydermatis were highly susceptible, whereas candida parapsilosis, candida pseudotropicalis, candida krusei, torulopsis glabrata, blastomyces dermat ... | 1989 | 2802565 |
| isolation and partial characterization of a plasma membrane-enriched fraction of blastomyces dermatitidis. | the isolation and characterization of a plasma membrane-enriched fraction is reported from the pathogenic fungus blastomyces dermatitidis employing a simplified and inexpensive procedure. the yeast cells, suspended in an osmotic stabilizer buffer, were subjected to gentle mechanical disruption followed by a three-step differential centrifugation to obtain a 40,000 x g sediment. this fraction showed 2.7- and 3.3-fold relative enrichment of the plasma membrane marker enzymes mg2(+)-atpase and 5'-n ... | 1990 | 2139489 |
| isolation, purification, and radiolabeling of a novel 120-kd surface protein on blastomyces dermatitidis yeasts to detect antibody in infected patients. | no well-defined blastomyces-specific antigens are currently available. we used sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting to identify immunologically active molecules in the cell wall of b. dermatitidis. a major immunoreactive 120-kd protein (wi-1) was present in all five strains studied and comprised 5% of the protein in the cell wall extract obtained after freezing and thawing yeast cells. wi-1 was recognized by serum from all 10 patients with blastomycosis bu ... | 1990 | 2295693 |
| attachment of blastomyces dermatitidis conidia to murine bronchoalveolar macrophages: characterization of binding and elicitation of respiratory burst. | we studied the mechanisms of adherence of blastomyces dermatitidis conidia to murine bronchoalveolar macrophages and the ability of the conidia to elicit an increase in macrophage o2- production, using an avirulent fungal strain. the number of cell associated conidia was counted by visual inspection of 2 hour macrophage monolayers incubated with conidia and o2- was measured by reduction of ferricytochrome c. adherence of conidia to bronchoalveolar macrophages was time dependent and reached a pla ... | 1990 | 2164798 |
| blastomycosis: fungal infections of the lung update: 1989. | three additions to the understanding of blastomycosis have been noted over the past several years. first, blastomyces dermatitidis has now been grown from soil in association with epidemics of infection, indicating that microfoci of the organism exist in nature. second, immune markers of previous infections have been used to help confirm that subclinical or asymptomatic cases occur in endemic areas. this is well recognized for other fungal infections, like histoplasmosis, and is increasingly rec ... | 1990 | 2247705 |
| comparison of enzyme immunoassay and immunodiffusion for the detection of canine blastomycosis. | two blastomyces dermatitidis commercial immunodiffusion antigens, meridian diagnostics and nolan-scott laboratories, and two b. dermatitidis yeast phase lysate antigens, t-58 and k-le, prepared in our laboratory were utilized in an enzyme-linked immunosorbent assay (elisa) for the detection of antibodies in 61 serum specimens from dogs with blastomycosis. all antigens used in the elisa were diluted to 50 ng of protein ml-1. immunodiffusion (id) tests were also performed on the sera using a nolan ... | 1990 | 2128645 |
| enzymatic activity profiling as a potential biotyping method for ajellomyces dermatitidis. | enzyme profiling was investigated as a means of recognizing biotypes and individual strains of ajellomyces dermatitidis (anamorph, blastomyces dermatitidis). eighteen north american and 2 african representatives were tested with the yeast-ident enzymatic activity profiling system (analytab products, plainview, n.y.). significant variation was found between isolates, particularly in beta-galactosaminidase activity. | 1990 | 2351722 |
| cottonseed extract versus pharmamedia for the in vitro mould-yeast conversion of blastomyces dermatitidis. | a cottonseed medium, based on a 1% aqueous extract of seeds of any of the eight indigenously available varieties of cotton belonging to gossypium hirsutum or gossypium arboreum, was evaluated for the mould-yeast conversion of blastomyces dermatitidis in vitro, and compared with pharmamedia agar as a control. the cottonseed agar was found to be as efficient as pharmamedia agar for the mould-yeast conversion of the 19 b. dermatitidis strains tested. therefore, cottonseeds provide an adequate and i ... | 1990 | 2380881 |
| therapeutic effect of the triazole bay r 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis. | a new triazole, bay r 3783, was compared with ketoconazole, itraconazole, and fluconazole, which were given via the alimentary tract at three dosages, and amphotericin b, which was given at 1 mg/kg intraperitoneally, in murine models of the systemic mycoses coccidioidomycosis, histoplasmosis, and blastomycosis. in a pulmonary coccidioidomycosis model, bay r 3783, fluconazole, and itraconazole were essentially equally efficacious and more active than ketoconazole in protecting mice against death; ... | 1990 | 2393272 |
| treatment of murine pulmonary blastomycosis with sch 39304, a new triazole antifungal agent. | sch 39304, a broad-spectrum azole derivative, was evaluated in an experimental mouse model of blastomycosis pneumonia. five days after being inoculated with blastomyces dermatitidis, infected mice were treated with either oral sch 39304, fluconazole, or intraperitoneal amphotericin b. a dose response protective effect was observed with sch 39304 at 5 to 100 mg/kg of body weight per day, with 5 mg of sch 39304 per kg per day providing activity similar to that of 100 mg of fluconazole per kg per d ... | 1990 | 2360825 |
| evaluation of nikkomycins x and z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis. | nikkomycins x and z, competitive inhibitors of fungal chitin synthase, were evaluated as therapeutic agents in vitro and in mouse models of coccidioidomycosis, histoplasmosis, and blastomycosis. in vitro, the nikkomycins were found to be most effective against the highly chitinous, dimorphic fungi coccidioides immitis and blastomyces dermatitidis, were less effective against yeasts, and were virtually without effect on the filamentous fungus aspergillus fumigatus. additionally, by transmission e ... | 1990 | 2344165 |
| development of long-term specific cellular immunity after acute blastomyces dermatitidis infection: assessments following a large point-source outbreak in wisconsin. | ninety-five persons exposed to a point-source of blastomyces dermatitidis in wisconsin in 1984 were evaluated 3 months after exposure for the development of specific cellular immunity, and the 48 infected persons were again evaluated 7 and 21 months after exposure. the immune response was assessed by an assay of [3h]thymidine uptake by lymphocytes proliferating in response to stimulation with blastomyces alkali- and water-soluble antigen (b-asws) or blastomycin and by skin testing with blastomyc ... | 1990 | 2295863 |
| endophthalmitis due to blastomyces dermatitidis. case report and review of the literature. | blastomycosis very rarely affects ocular structures other than the eyelid. it is even more unusual for involvement to occur in the absence of active widespread disease. the authors report a 71-year-old woman with unresponsive endophthalmitis of the right eye who underwent enucleation. results of microscopic examination of the globe showed severe acute and chronic granulomatous and nongranulomatous endophthalmitis as well as numerous fungi having the histologic features of blastomyces dermatitidi ... | 1990 | 2326009 |
| evidence of subclinical blastomycosis in forestry workers in northern minnesota and northern wisconsin. | to investigate the incidence of remote subclinical blastomycosis in a high-risk population of forestry workers. | 1990 | 2220880 |
| histoplasmosis duboisii (african histoplasmosis). an african case reported from chile with ultrastructural study. | a case of histoplasmosis duboisii in a 30 year-old engineer is presented. the diagnosis was made with the help of light microscopy, electron microscopy and cultures. although diagnosed in chile, the patient probably acquired the disease in the endemic african area, more precisely in the ivory coast. differential diagnosis between histoplasma capsulatum var. capsulatum and histoplasma capsulatum var. duboisii is based primarily on the larger in-vivo yeast form size of the latter. electron microsc ... | 1990 | 2247379 |
| giant forms of blastomyces dermatitidis in the pulmonary lesions of blastomycosis. potential confusion with coccidioides immitis. | typical yeast-phase cells of blastomyces dermatitidis have a characteristic appearance in tissue sections. fungal morphologic variation occurs infrequently in the lesions of blastomycosis, yet it can complicate the differential diagnosis, particularly if fresh tissue is not available for microbiologic culture. the authors report a case of pulmonary blastomycosis, confirmed by culture and direct immunofluorescence, in which some of the yeast-like cells were abnormally large. these giant yeast-lik ... | 1990 | 2321590 |
| fluconazole: a new triazole antifungal agent. | fluconazole is a fluorine-substituted, bis-triazole antifungal agent. its mechanism of action, like that of other azoles, involves interruption of the conversion of lanosterol to ergosterol via binding to fungal cytochrome p-450 and subsequent disruption of fungal membranes. activity against aspergillus spp., blastomyces dermatitidis, candida spp., coccidioides immitis, cryptococcus neoformans, histoplasma capsulatum, and paracoccidioides brasiliensis has been demonstrated in several animal mode ... | 1990 | 2260347 |
| efficacy of brain heart infusion-egg albumen agar, yeast extract phosphate agar and peptone glucose agar media for isolation of blastomyces dermatitidis from sputum. | the efficacy of brain heart infusion (bhi)-egg albumen agar, yeast extract phosphate agar and several modified peptone glucose agar media was evaluated for isolation of blastomyces dermatitidis from sputum concomitantly seeded with the yeast form of the pathogen and candida albicans. based upon high per cent culture positivity of sputum, improved recovery (cfu/ml) of the seeded inoculum, faster growth rate of b. dermatitidis and low level of contamination, bhi-egg albumen agar, followed by yeast ... | 1990 | 2293031 |
| enzyme immunoassay detection of antibodies in canine blastomycosis using blastomyces dermatitidis lysate antigens. | a blastomyces dermatitidis yeast phase lysate antigen (t-58) prepared in our laboratory was used in an enzyme-linked immunosorbent assay (elisa) for the detection of antibodies in 201 serum specimens from dogs with blastomycosis. in addition 36 sera from non-infected dogs from an endemic area for blastomycosis and 36 sera from non-infected dogs residing in a blastomycosis non-endemic area were assayed. sensitivity values ranged from 96.2% (53 pre-treatment sera) to 88.5% (148 post-treatment sera ... | 1990 | 2093845 |
| comparison of fluconazole and ketoconazole in experimental murine blastomycosis. | fluconazole, a new oral triazole antifungal agent, was tested against blastomyces dermatitidis in vitro and in a murine model (pulmonary challenge) and compared with ketoconazole, an oral imidazole known to be effective against this agent in mice and in humans. although fluconazole appeared less active than ketoconazole in vitro, in experiments involving 3 weeks of treatment and 2 months of observation, fluconazole was greater than 10 times as potent (mg/kg) in vivo against blastomycosis (prolon ... | 1990 | 2139516 |
| detection of antibody responses and delayed dermal hypersensitivity with blastomyces dermatitidis yeast and mycelial lysate antigens. | yeast cell lysate and mycelial lysate antigens prepared from one strain (t-58) of blastomyces dermatitidis were evaluated with respect to the detection of antibodies and delayed dermal hypersensitivity. comparable elisa sensitivity values were evidenced with the two antigens when assayed against serum specimens from dogs with blastomycosis, sera from non-infected dogs residing in endemic and non-endemic areas for blastomycosis and sera from rabbits that were hyperimmunized with b. dermatitidis a ... | 1991 | 1886639 |
| concurrent infection with sporotrichosis and blastomycosis: an unusual case. | two facial nodules and a pulmonary infiltrate occurred in a twenty-one-year-old man. tissue cultures from one of the facial lesions showed both sporothrix schenckii and blastomyces dermatitidis. cultures from lung biopsy tissue grew b. dermatitidis. this is the first known reported case of sporotrichosis and blastomycosis occurring concurrently in the same cutaneous lesion. | 1991 | 1935247 |
| variable colonial phenotypic expression and comparison to nuclei number in blastomyces dermatitidis. | we examined colonial phenotypes of five isolates of blastomyces dermatitidis at 33, 35 and 37 degrees c on four growth media. three different colony types were identified: yeast, mycelial, and a mixed type consisting of both yeast and mycelia. each isolate varied in its ability to grow on the different media and at different temperatures, and in the types of colonies it produced in the various temperature-media combinations. quantification of the number of nuclei per yeast cell by fluorescent st ... | 1991 | 1716307 |
| fulminant blastomycosis with blastomycotic infection of a cerebral glioma. light microscopic and ultrastructural observations. | except for isolated case reports, blastomycosis has not been identified as a significant problem in immunosuppressed patients. we describe an unusual case with blastomycotic infection of a cerebral glioma in a 56-year-old man who underwent radiotherapy for his tumor and died of fulminant blastomycotic pneumonia. this is believed to be the first reported case of blastomyces dermatitidis infection of a cerebral glioma. the light microscopic and ultrastructural features of b. dermatitidis, the gian ... | 1991 | 1767635 |