Publications

pneumocystis carinii pneumonia presenting as localized nodular densities.		1974	4547531
histopathology of pneumocystis carinii infestation and infection in malignant disease in childhood.		1974	4547556
editorial: a safe procedure for diagnosis of pneumocystis carinii pneumonia.		1974	4547557
the role of membrane lung support in transient acute respiratory insufficiency of pneumocystis carinii pneumonia.		1974	4547590
transbronchial forceps lung biopsy through the fiberoptic bronchoscope in pneumocystis carinii pneumonia.		1974	4547596
continuous negative chest-wall pressure as therapy for severe respiratory distress in older children.	continuous negative chest-wall pressure (cnp) was used to treat five children, 4 to 11 years of age, who had progressively severe respiratory distress caused by pneumocystis carinii penumonitis. after initial improvement, two patients developed progressive increases in respiratory rate, alveolar-arterial oxygen gradient, intrapulmonary right-to-left shunt, and hypoxia. the disease ended fatally in both. the remaining three patients continued to improve and recovered from their pulmonary disease. ...	1975	1080095
letter: pneumocystis carinii in a husband and wife.		1975	51439
current status of laboratory diagnosis of pneumocystis carinii pneumonitis.		1975	52430
editorial: pneumocystis carinii pneumonitis.		1975	53502
letter: pneumocystis carinii pneumonitis.		1975	53762
[altered morphopathological aspects of pneumocystis carinii pneumonia].	the present paper reports a study on 27 children who died of interstitial pneumonia due to pneumocystis carinii in the clinics of pediatrics, cluj, in the course of 3 years (1971-1973). the incidence was 10% of the children who died from acute pneumonia. the authors show the morphopathologic possibilities of identifying the pictures modified by plasmocytic pneumonia due to association of the disease with bacterial and viral infections. these cases represent a quarter of the authors' cases. the i ...	1975	128100
an autopsy case of generalized cytomegalic inclusion disease associated with pneumocystis carinii pneumonia.		1975	173920
pulmonary infections after kidney transplantation.	seventy-five pulmonary infections out of 173 kidney transplantations have been observed in 62 graft-recipients, from 1965 to 1973. the aetiologic organism is a bacteria in 80% of the cases, a fungus in 8% of the cases, cytomegalovirus and pneumocystis carinii in 11% of the cases. a close relationship between infection and a previous transplant crisis was noted in 66% of the cases. the most efficient diagnostic procedures were pleural and open lung biopsy as well as cultures of blood, pleural fl ...	1975	172885
the air bronchogram in interstitial disease of the lungs. a radiological-pathological correlation.	the air bronchogram classically signals an end-air-space or "alveolar" filling process such as alveolar proteinosis and bronchioloalveolar-cell carcinoma. however, it can also occur in interstitial diseases, possibly leading to compressive atelectasis and causing crowding of tissue around open airways. in addition, such disease processes may encroach on distal airways, producing obstructive pneumonia which may then surround open proximal airways, as in sarcoidosis and lymphoma. in mixed "alveola ...	1975	166409
roentgenographically atypical pneumocystis carinii pneumonia.	two patients with renal transplants were admitted for evaluation of fever. during the course of hospitalization both had hectic fever and arthralgia. pulmonary symptoms were absent or minimal. in one patient the admitting chest roentgenogram was entirely normal and in the other only a small focal abnormality was apparent. hypoxemia occurred even in the presence of normal or nearly normal chest roentgenograms. the diagnosis of pneumocystis carinii infection was made by bronchoscopic brush biopsy ...	1975	163066
letter: early diagnosis of pneumocystis carinii infection.		1975	52098
diagnosis and therapy of primary defects of immunity (author's transl).	immunological responses are divided into those mediated by humoral antibody (b-cells) and those by cells (t-cells). both depend upon the activity of small lymphocytes which become thymus or bursa analogue dependent during embryonic development. primary immundeficiencies are therefor defects of lymphocytes attributed in most cases to gene defects. early diagnosis is the necessary prerequisit for possible treatment. tests for assessing the cellular immune status are: skin testes and in vitro tests ...	1975	2800
current status of treatment of pneumonia.	proper treatment of pneumonia is dependent upon a correct diagnosis. pneumonia may be due to infectious agents, allergic phenomena, or chemical causes. treatment regimens are outlined for the various types of pneumonia--pneumococcal, staphylococcal, fungal, and pneumonia due to gram-negative and anaerobic gram-negative bacilli, to blastomyces dermatitidis, and to the parasite pneumocystis carinii. in discussing current concepts of treatment, several well-known methods are emphasized, as well as ...	1975	792
an autopsy case of lymphosarcoma associated with pneumocystis carinii pneumonia, cytomegalovirus infection, and miliary tuberculosis.		1975	181106
diagnostic fiberoptic bronchoscopy: techniques and results of biopsy in 600 patients.	six hundred patients underwent diagnostic flexible fiberoptic bronchoscopy (ffb). the two diseases most frequently encountered were bronchogenic carcinoma in 330 patients (55 percent) and bacterial infection in 94 (16 percent). a positive cytology on biopsy material was obtained in 279 of 330 patients (85 percent) with primary lung cancer. fluoroscopy was a valuable aid in diagnosing bronchogenic carcinoma, since 42 percent of the tumors were not visible endoscopically and required fluoroscopic ...	1975	168036
compatible bone marrow transplantation and immunologic reconstitution of combined immunodeficiency disease.	to date, bone marrow transplantation affords the only successful means of achieving full immunologic reconstitution of patients with severe combined immunodeficiency disease (scid). we have achieved immunologic reconstitution in 6 of 7 scid patients using marrow transplants from compatible sib donors. one child died of pneumocystis carinii pneumonia following early immunologic reconstitution. a second child died of sepsis without evidence of engraftment, despite 3 marrow grafts, and a third died ...	1975	238681
[pneumocystis carinii infections following kidney transplantation].	four adult recipients of cadaveric renal homografts acquired pneumocystis carinii infections from which they subsequently died. the disease in adults under immunosuppressive therapy runs a course different from the disease observed in newborns. the clinical course is rapidly progressive and early diagnosis by means of aggressive diagnostic procedures is mandatory. to prevent a fatal outcome, treatment even on suspicion is suggested. epidemiologically, a person-to-person spread seems possible and ...	1975	766162
fatal infections in protein-calorie malnourished children with thymolymphatic atrophy.	the clinicopathological features of 25 children who died with protein-calorie malnutrition were studied. all but four subjects were found at necropsy to have nutritional thymectomy and all but 3 died of infectious diseases. the infectious agents were chiefly intracellular micro-organisms including miliary tuberculosis, herpes simplex, varicella, measles, pneumocystis carinii, and plasmodium falciparum. staphylococcal infections, salmonellosis, shigellosis, strongyloidiasis, and hookworm were oth ...	1975	805568
pneumocystis carinii infection in splenectomized owl monkeys.	interstitial pneumonia due to pneumocystis carinii was diagnosed in 2 splenectomized owl monkeys. pneumonia was considered an important lesion in 1 monkey, but only an incidental finding in the 2nd monkey. nephritis was considered to be the primary lesion in both monkeys.	1975	809395
the effect of dimethyl sulfoxide on pneumocystis carinii.		1975	1079424
treatment of pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole.	pneumocystis carinii pneumonitis (pcp) is fatal in 90 to 100% of the cases if no treatment is given. trimethoprim-sulfamethoxazole (tmp-smx) was used at one of two dosage levels in the treatment of 20 children with pcp and cancer. of 14 patients treated with 20 mg tmp--100 mg smx/kgd, 12 recovered and 2 died. treatment of the fatal cases and one of the patients who recovered was supplemented with pentamidine. when six patients were treated with 4 to 7 mg tmp--20 to 35 mg smx/kgd, four recovered ...	1975	1079469
letter: pneumocystis carinii pneumonia.		1975	1079057
pneumocystis carinii infestation.		1975	1080481
letter: smooth muscle antibody in children with pneumocystis carinii pneumonia.		1975	1081135
letter: pneumocystis carinii in a vietnamese foundling.		1975	1081338
[2 cases of pneumocystis carinii pneumonia. case 1: diffuse interstitial pneumonia observed in a case simulating dermatomyositis. case 2: diffuse interstitial pneumonia in acute myelocytic leukemia].		1975	1082043
[interstitial pneumonia in children on cystostatic treatment for malignant systematic disease (author's transl)].	the radiologic appearances of interstitial pneumonia are described as they appeared in 39 children treated with immunosuppressive and cytostatic substances given for malignant systemic disease. at the time most of the children were in a stage of remission of their basic illness. in most of them there may have been a pneumocystis carinii infection. 15 children died of this pneumonia. in the majority of post-mortem examinations pneumocysts could be detected.	1975	1082626
infections in children with acute leukemia.	twenty children with all that died in 1959-1960 and 59 children with all that died in 1969-1970 were analyzed according to the infections at both their terminal illness and their initial presentations. despite the availability of more effective agents for pseudomonas and staphylococcus, the pattern of infecting organisms at the terminal illness did not change appreciably in this decade. e. coli, pseudomonas, staphylococcus, and candida were the principal organisms involved as a cause of death. t ...	1975	778573
pneumocystis and histoplasma infections in wild animals from the amazon region of brazil.	routine examination of tissues from wild forest rodents from amapá, north brazil, revealed pneumocystis carinii in lung smears from a newly captured oryzomys capito (cricetidae). acute, fatal infections with this parasite are also recorded in a number of captive "coatimundis", nasua narica (carnivora: procyonidae) and a sloth, bradypus tridactylus (edentata). pneumocystis was also encountered in lung smears from a newly captured and apparently healthy sloth, choloepus didactylus. the presence of ...	1975	1084602
latent pneumocystis carinii infections in some mammals from taipei hsien, taiwan.		1975	1083423
[pneumonia as a cause of death in children (author's transl)].	the yearly death-rate from pneumonia in children aged one month to 15 years has fallen in schleswig-holstein from 1.8 (1954-1958) to 0.6 per ten thousand (1969-1973). at the same time, total death-rate in the same age group has fallen from 14.5 to 9.3 per ten thousand children. the proportion of pneumonia in the total death-rate was 5.3% in 1971-1973, 1.6% in the first month of life and, after the sixteenth year, 2.3%. pneumonia was in fourth place (after accident, malformation and neoplasm) as ...	1975	805694
failure of pentamidine isethionate to provide chemoprophylaxis against pneumocytis carinii infection in rats.	latent pneumocystis carinii infections were exacerbated in 54 adult male sprague-dawley rats by administration of alternating subcutaneous doses of hydrocortisone-21-phosphate and of cortisone acetate three times a week, plus 0.5% chlortetracycline in their drinking water, until death or the termination of the experiment at 120 days. twenty-eight of the rats were also given pentamidine isethionate (4mg/kg) intramuscularly daily for 14 days. pentamidine-treated animals that died within the 120 da ...	1975	1079218
[pneumocystis carinii pneumonia after kidney transplantation. early diagnosis by distal bronchial brushing].	distal bronchial brushing is one of the methods used in the in vivo indentification of pneumocystis carinii, a parasite associated with severe pneumonia, the development of which is induced by immuno-depression, particularly after renal transplantation. in three patients the pathogenic agent was demonstrated in alveolar material obtained in this way. the technique is simple and risk-free. it may be used early and repeatedly.	1975	1093127
pneumocystis carinii pneumonia. diagnosis by lung biopsy.	pneumocystis carinii pneumonia was suspected in 52 patients who underwent lung biopsy for diagnosis of diffuse pulmonary infiltrates. all but five of the procedures were limited thoracotomies. there were no instances of significant postoperative hemorrage or of pneumothorax compromising ventilation. the diagnosis of p. carinii pneumonia was made rapidly from imprints of the lung stained by the gram-weigert method in the 18 patients who had p. carinii pneumonia. over-all, the rate of recovery fro ...	1975	1079692
letter: roentgenographically atypical pneumocystis carinii pneumonia.		1975	1098535
pneumocystis carinii infections in zoo animals.	pneumocystis carinii was found to be present in the lungs of twenty-three zoo animals in the netherlands. the following species were represented: red kangaroo, common tree shrew, senegal-galago, demidoff's-galago, brown howler monkey, woolly monkey, long-haired spider monkey, white-eared marmoset, chimpanzee, three-toed sloth, palm squirrel, red panda, fennec fox, tree hyrax and large-toothed hyrax.	1975	1079994
transbronchial lung biopsy via the fiberoptic bronchoscope. experience with 107 consecutive cases and comparison with bronchial brushing.	transbronchial lung biopsy (tbb) was performed during fiberoptic bronchoscopy under fluoroscopic guidance in 107 patients. tbb was diagnostic in 17 of 21 (81 percent) cases with localized malignant lesions greater than 4 cm in diameter and bronchial brushing was positive in 12 (57 percent). tbb was diagnostic in 14 of 24 (58 percent) cases with localized malignant lesions equal to or less than 4 cm in diameter, whereas brush biopsy was positive in 7 (29 percent). in 13 cases with suspected pneum ...	1975	1080700
intensity of immunosuppressive therapy and the incidence of pneumocystis carinii pneumonitis.	one hundred and forty-nine children with acute lymphocytic leukemia treated according to a prospective protocol were randomized after induction of remission and central nervous system (cns) irradiation to receive maintenance chemotherapy with 1, 2, 3, or 4 chemotherapy agents. the incidence of p. carinii pneumonitis (pcp) was 5.0, 2.3, 2.2, and 22.4%, respectively, during the period of maintenance therapy. an additional 31 patients enrolled in the same study were placed in special categories to ...	1975	1081905
atypical radiographic features in pneumocystis carinii pneumonia.	the chest films in 30 proved cases of pneumocystis carinii pneumonia were reviewed to determine the incidence of atypical radiographic findings. seventeen of 30 patients or 56% presented at least one atypical radiographic finding during the course of the disease. unilateral distribution, lobar involvement, abscess formation, fulminant progression, and atelectatic changes were observed in more than half the patients. a classic radiographic presentation, justifying treatment without biopsy, was se ...	1975	1082150
[fever, edema, eosinophilia and acute pneumonia: bilateral, diffuse pneumocystis carinii pneumonia and candida pneumonia of the left lung (evaluation of eosinophilia)].		1975	1082519
pulmonary granulomatous pneumocystosis following renal transplantation. report of a case.	pulmonary granulomas of sarcoid type in a patient who was on long-term immunosuppressive therapy following renal transplantation are described. pneumocystis carinii was identified within the lesions. this is believed to be the first description of this type of reaction to pneumocystis in the adult patient on immunosuppressive therapy.	1975	1090147
pneumocystis carinii pneumonia: a cluster of eleven cases.	an unusual cluster of 11 patients with pneumocystis carinii pneumonia occurred in a 3-month period at memorial hospital, new york. ten of the 11 patients had lymphoma or leukemia. in 7 patients, corticosteroid therapy was decreased or stopped shortly before pneumocystis pneumonia was diagnosed. the pediatric patients had extensive contact in the outpatient department, and three of them had roomed together, suggesting the possibility of man to man transmission. tree of 4 adult patients with hodgk ...	1975	1094880
pulmonary and extrapulmonary support for patients with pneumocystis carinii pneumonia.	temporary extrapulmonary oxygenation may benefit selected patients with pneumocystis carinii pneumonia who exhibit severe respiratory insufficiency. four persons were considered candidates for extrapulmonary oxygenation with a membrane lung while under treatment for pneumocystis pneumonia. in one patient, attempts to institute membrane lung circulation were postponed until his condition was terminal. in another individual, membrane lung support was discontinued prematurely because of complicatio ...	1976	1087954
pneumocystis carinii pneumonia and primary immune deficiency diseases.	during a 3-year period, 50 cases of pneumocystis carinii pneumonia in children less than 5 years old were reported to the parasitic disease drug service, center for disease control. primary immune deficiency diseses constituted the most frequent underlying diseases in patients less than 1 year old (24/29 cases, 83%), whereas acute lymphatic leukemia was the most common underlying diseases in children 1-4 years old (17/21 cases, 81%). severe combined immunodeficiency was the most common type of i ...	1976	1087961
atypical radiographic features in pneumocystis carinii pneumonia.	in a review of clinical, pathologic, and radiographic findings from 30 patients with confirmed pneumocystis pneumonia, the disease presented a typical radiographic picture of acute bilateral perihilar and basilar infiltrate progressing to diffuse alveolar consolidation within 3-5 days and unassociated with adenopathy or pleural changes in 13 patients. however, the incidence of atypical radiographic features was appreciable (17 of the 30 patients showed at least one atypical finding) and, in addi ...	1976	1087962
pneumocystis carinii pneumonia in children with acute leukemia.		1976	1088423
transbronchial lung biopsy via the fiberoptic bronchoscope in the diagnosis of diffuse pulmonary infiltrates in the immunosuppressed host.	the differential diagnosis of diffuse pulmonary infiltrates in the immunosuppressed patient is broad. many of the etiologies are amenable to specific therapy. although endobronchial brush biopsy has been used to identify many infections, including pneumocystis carinii, it was less effective in the diagnosis of noinfectious infiltrates. transbronchial lung biopsy via the fiberoptic bronchoscope provided lung tissue that could be studied histologically, which increased the diagnostic yield without ...	1976	1087949
percutaneos pulmonary needle diagnosis of pneumocystis carinii pneumonitis.	percutaneous pulmonary needle aspiration (pc-a) is one of several diagnostic techniques capable of providing material in which pneumocystis carinii organisms can be identified. this simple procedure, readily performed by most physicians, can be rapidly done under local anesthesia, requiring no sedation, general anesthetic, or multiple support personnel. when the chest roentgenographic evidence suggests diffuse involvement, pc-a may be performed at the bedside; if more patchy in distribution, und ...	1976	1087950
open lung biopsy in the diagnosis of pneumocystis carinii pneumonia.	lung biopsy remains the essential cornerstone in the diagnosis of pneumocystis pneumonia. whatever technique can establish this diagnosis safely and early in order to get treatment started quickly should be used. open lung biopsy remains a candidate for the diagnostic method of choice because if offers some advantages over percutaneous needle biopsy. there is a greater supply of competent thoracic surgeons in most hospitals than of physicians who are proficient with needle biopsy. the direct vis ...	1976	1087951
pneumocystis carinii infection: diagnosis and pathogenesis.	the methods of diagnosis of pneumocystis carinii infection are reviewed; a high index of suspicion of the disease, particularly in the immunodeficient patient, is stressed and the classic morphology of the organism is described. discussed are the known immunologic features gleaned from clinical and pathologic data from the literature and the reported cases from the university of minnesota hospitals. the importance of the complete investigation of the immune status of every patient who develops p ...	1976	1087952
cytologic diagnosis of pneumocystis carinii.		1976	1087953
[radiological evaluation of the course of pneumocystosis (author's transl)].	serial chest x rays were performed on 124 infants in an orphanage with endemic pneumocystic carinii infection. the infection was serologically and autoptically proven in 98 cases. the interstitial infiltrate in the lungs is not specific for pneumocystis carinii infection, but is the result of the host reaction, which persists after the antigen has been destroyed. the interstitial infiltrate is therefore neither time-related nor diagnostic and cannot be used as a guideline for therapy. the treatm ...	1976	1083036
[diagnosis of pneumocystic carinii pneumonia by lavage of the bronchial system (author's transl)].	this report deals with a 10 year old girl suffering from an acute lymphoblastic leukemia since 1971. the child was hematologically in full remission, when she developed a pneumonia due to pneumocystis carinii. the diagnosis was established by demonstrating the agent in bronchial secretions. the material was obtained by rinsing the bronchial system. the patient was treated with pentamidine and co-trimoxazol (bactrim) with good success.	1976	1086403
pneumocystis carinii pneumonia in two vietnamese refugee infants.		1976	1084514
pneumocystis carinii pneumonia.		1976	1086376
[parasites of the respiratory system: research and significance (author's transl)].	a review is made of the methods of diagnosing both autochthonous and exotic protozoal and helminthic diseases of the respiratory system. referring to protozooses, recent findings on respiratory pathology due to amoebae of the genus acanthamoeba are commented, and modern methods are discussed of checking for pneumocystis carinii in the patient, not just on autopsy material. referring to helminthiases, in addition to pulmonary echinococcosis which is of prevalent interest in italy, attention is al ...	1976	1087869
trimethoprim-sulfamethoxazole treatment of pneumocystis carinii pneumonia in adults.		1976	1085413
editorial: treatment of pneumocystis carinii pneumonitis.		1976	1085414
unusual roentgenographic manifestation of pneumocystis carinii pneumonia.	an immunologically deficient patient had two large nodular densities on the chest x-ray film. on autopsy, large solid accumulations and diffuse pneumonitis with pneumocystis carinii were found. this represents an unusual manifestation of pneumocystis carinii.	1976	1085688
[pneumocystis carinii pneumonia associated with stomach neoplasm and liver cirrhosis--an autopsy study and statistical observation].		1976	1085829
treatment of pneumocystis carinii pneumonia: current status of the regimens of pentamidine isethionate and pyrimethamine-sulfadiazine.	a randomized clinical trial is under way comparing the relative merits of pentamidine isethionate and pyrimethamine-sulfadiazine in the management of patients with pneumocystis carinii pneumonia. twenty-one patients have entered the trial. both regimens have produced at least one complete recovery in biopsy-proved pneumocystis pneumonia. two patients have died from pneumocystis pneumonia after being treated with a combination of both regimens. initial observations on comparative toxicity indicat ...	1976	1087955
treatment of pneumocystis carinii pneumonia in infancy.	pentamidine is recommended for the therapy of pneumocystis carinii pneumonia either alone or, in severe cases, combined with pyrimethamine. attention is drawn to the importance of supporting symptomatic treatment, particularly with the promethazine-hydergine cocktail, and to the possibilities for general and drug prophylaxis.	1976	1087956
endemic infantile pneumocystis carinii infection: the shiraz study.	orphanage epidemics of interstitial plasma cell pneumonia (ipcp) occur among premature infants whose passive immunity due to maternally transferred antibodies has lost its effectiveness before the infants' humoral immune systems have reached sufficient maturity to respond effectively to pneumocystis carinii. ipcp occurs also among mature newborns receiving substandard care in understaffed and crowded orphanages. infantile diarrhea in these institutions leads to marasmus and deficient immune resp ...	1976	1087958
pneumocystis carinii pneumonia in the united states: epidemiologic, diagnostic, and clinical features.	analysis of 194 patients with confirmed pneumocystis carinii pneumonia in the united states over a 3-year period revealed that p. carinii pneumonia occurred almost exclusively in the immunosuppressed host who had a serious underlying disease. the epidemiologic features of pneumocystis pneumonia primarily reflected those of the underlying disease. p. carinii was identified antermortem in 81% of the cases usually by biopsy or needle aspiration of the lung, procedures associated with considerable m ...	1976	1087960
neurologic involvement in seven patients with behçet's disease.	of 25 patients with behçet's disease seen in five years at the mayo clinic, seven had central nervous system involvement. the mean interval from onset of behçet's disease to central nervous system involvement was 1.3 years, and the mean period of observation thereafter was 3.8 years. all patients had headache and fever during or preceding exacerbations of the central nervous system disease, and all had cerebrospinal fluid pleocytosis (white cell counts ranged from 6 to 490/mm3) with predominant ...	1976	952291
combination chemotherapy with adramycin (nsc-123127) and dimethyl triazeno imidazole carboxamide (dtic) (nsc-45388) in children with metastatic sold tumors.	combination chemotherapy with adriamycin and dtic was used in 102 evaluable patients under 15 years of age who had previously treatted metastatic solid tumors. responses, defined as 50% or more reduction in all tumor masses, occured in 10 out of 27 patients with neuroblastoma, 3 out of 8 patients with wilms tumor, 7 out 15 patients with ewing sarcoma, 2 out of 6 patients with osteosarcoma, 5 out of 13 patients with rhabdomyosarcoma, and 15 out of 33 patients with miscellaneous tumors which incl ...	1976	958160
pharmacologic aspects of pentamidine.	pentamidine is an aromatic diamidino compound synthesized originally for the therapy of trypanosomiasis. the pharmacologic effects of pentamidine vary, depending on its route of administration. in animals, the dominant effects have been a precipitous, transitory drop in blood pressure after injection and renal toxicity following repeated administration. to avoid the possibility of immediate toxic reactions associated with iv administration, we now usually give the drug im to humans. further inte ...	1976	1018718
[current aspects of differentiation and treatment of pneumocystis carinii pneumonia (author's transl)].	there are two types of pneumocystis carinii pneumonia. one is seen in premature and atrophic infants mainly during the 2nd to 6th month, with massive interstitial proliferation of plasmacells and acute respiratory crisis. the second typ is observed in immunodeficient children and adults with only little or no plasmacell infiltration due to the hypoimmune, hypoergic state. pentamidine is the drug of choice in the therapy of pneumocystis carinii pneumonia; in serious cases it will be combined with ...	1976	1084954
microtubules in pneumocystis carinii.		1976	1086555
[assessment of the respiratory system in children following pneumocystis carinii pneumonia].		1976	1087402
lung complications during immunosuppressive treatment in renal transplant recipients.	pulmonary complications among 77 renal transplant recipients have been analysed. in the immediate postoperative period complications occurred with the same frequency as after other operations. later on, usually within 6 months, pneumonia caused by bacteria, pneumocystis carinii, cytomegalovirus and fungi occurred. the lung changes may indicate the underlying infecting organisms. mortality from pneumonia was 14% (11/77) including two patients with lung aspiration following emergency surgery. pulm ...	1976	781834
[diagnosis of pneumocystis carinii pneumonia by indirect immunofluorescence. technic, value of limitations of the method].	the diagnosis of pneumocystis pneumonia can be established by indirect immunofluorescence test performed on the sera of the patients. this investigation has proved to be valid since it gives 50 p.cent of positive results in 16 confirmed cases. the false negative results can be imputed in some patients, to the extreme severity of the immune deficiency.	1976	792806
pneumocystis carinii as the cause of human disease: historical perspective and magnitude of the problem: introductory remarks.	the history of the discovery of pneumocystis carinii as the cause of interstitial plasma cell pneumonia of infants and of opportunistic infection with this parasite in the lungs of immuno-suppressed or severely debilitated adults and children is summarized with an extensive bibliography of the world literature through 1959. the problem of incriminating a nearly ubiquitous saprophyte as the cause of a disease and of elucidating the factors responsible for its causing pathogenesis in certain indiv ...	1976	798122
pulmonary pneumocystosis in nonhuman primates.	pulmonary infection with pneumocystis carinii was detected in two aged owl monkeys (aotus trivirgatus) and two young chimpanzees (pan troglodytes). the clinical histories of the owl monkeys were similar and included progressive weight loss, anorexia, failure to thrive, and death. one of the owl monkeys had no concurrent disease, whereas the other had been experimentally inoculated with treponema pallidum 44 months before death. in both chimpanzees, an underlying myeloproliferative malignant neop ...	1976	814879
therapy and prophylaxis of pneumocystis carinii pneumonia.	pentamidine isethionate and sulfadoxine plus pyrimethamine are excellent therapeutic agents in experimental and hypoergic, hypoimmune pneumocystosis as well as in focal interstitial plasma cell pneumonia (ipcp) in infants. their effectiveness is seriously limited in cases in which either a diffuse massive plasma cell exudate has been established or in adults in whom the phagocytic and resorptive facility is depressed. infantile pneumocystosis leading to ipcp can be completely prevented by proper ...	1976	828241
[interstitial pneumopathies in children treated for malignant diseases].	the authors report 21 cases of severe interstitial pneumonitis observed in 1974 in paris, in children with malignancies, either solid tumours or leukemias. twelve patients died. the incidence of these complications in children with intensive chemotherapy and the clinical symptoms which may reveal them are reviewed; the bad prognosis of measles in these patients is stressed. radiological findings are described and the possible wrong diagnoses are listed. among viral infections, measles is the sev ...	1976	1085139
[immunologic aspects of pneumocystis carinii pneumonia in the adult].		1976	1085397
[pneumocystis carinii pneumonias in the adult].		1976	1085398
abnormal pulmonary gallium accumulation in p. carinii pneumonia.	the potentially fatal interstitial pneumonia of pneumocystis carinii is a frequent opportunistic invader of patients treated for malignancy with immunosuppressive and cytotoxic agents. generalized ga-67 pulmonary localization which is markedly disproportionate to the clinical and radiographic findings has led to earlier diagnoses by open lung biopsy in this setting. the potential usefulness of gallium scintigraphy in patients with suspected p. carini pneumonia is presented.	1976	1083546
[pneumocystis carinii pneumonia in infants at the children's hospital in warsaw].		1976	1083982
[progress in the diagnosis and treatment of pneumocystis carinii pneumonia].		1976	1084066
infection due to pneumocystis carinii simulating lobar bacterial pneumonia.		1976	1084255
[autoantibodies in children with pneumocystis carinii pneumonia].		1976	1083006
pneumocystis pneumonia: the importance of early open lung biopsy.	pulmonary infection due to pneumocystis carinii is now recognized as the leading cause of death from infection in patients with a hematologic malignancy who are in remission. effective treatment requires suspicion of the infection in susceptible patients and rapid identification of the organism. in most patients, open lung biopsy performed through a small anterior thoracotomy provides immediate identification or exclusion of the organism, thus allowing treatment of infected patients and avoidanc ...	1976	1083218
bilateral interstitial pneumonia in acute lymphoblastic leukemia.	of 148 children with acute lymphoblastic leukemia (all) 34 had bilateral interstitial pneumonia (bip). their records were reviewed retrospectively to evaluate the incidence of this pneumonia and delineate the various etiologic factors involved. all but 1 were in remission; 82% of the episodes occurred within the first 6 months, the majority of these occurring during the first 3 months of diagnosis of all; 16 were receiving methotrexate (mtx), and 14 were receiving combination chemotherapy with v ...	1976	1069476
infections with pneumocystis carinii.	studies were reviewed on attempts to apply serologic methods for the laboratoary diagnosis of pneumocystis pneumonia and for epidemiologic surveillance in outbreaks of this disease. at autopsy the parasite was found in 7.7% of patients with a clinically latent infection. in this series of patients, parasitologic findings were not correlated with the results of a complement fixation (cf) test or with those of an indirect fluorescent antibody test. the high incidence of serologic reactivity in the ...	1976	798123
immunopathologic aspects of pneumocystis carinii pneumonia in infants as revealed by immunofluorescence and electron microscopy.	lung tissue, lymph nodes, and spleen from infants 4-15 weeks old who died of pneumocystis carinii pneumonia were studied by immunofluorescence and immunoelectron microscopy. the results strongly suggest that antibodies to p. carinii synthetized in lungs by inflammatory infiltrates and in regional lymph nodes are essential in the elimination of p. carinii from infected lungs through their opsonization of the p. carinii organisms. disintegration of p. carinii conglomerates subsequent to the bindin ...	1976	798124
pneumocystis carinii pneumonia in renal transplant recipients.	discussed are incidence, predisposing factors, presenting symptoms, diagnostic and isolation procedures, and therapy of pneumocystis carinii pneumonia in renal transplant recipients. a case is reported of a 46-year-old recipient of a cadaveric kidney, who develop p. carinii infection and was successfully treated with pentamidine isethionate.	1976	798125
[pneumocystis carinii pneumonia in infants].		1976	821124
[alveolo-interstitial pneumocystis carinii pneumonia].		1976	821125
[unusual complication under immunosuppressive treatment: pneumocystis carinii pneumonia].		1976	793201
[anatomo-clinical and experimental studies on pneumocystis carinii. preliminary note].	the authors have been interested over the last year in the detection of pneumocystis carinii in patients with immune deficiencies, whether natural or artificial. after a brief historical and general introduction, they discuss their procedures, the pathological substances available, the staining techniques and the examination of autopsy specimens. they undertook experimental work on this micro-organism, e.g. the development of the germ in immuno-depressed rats and, from this material, numerous va ...	1976	185701
diagnosis of cytomegalovirus pneumonia in compromised hosts.	sixteen patients with cytomegalovirus pulmonary infection are described. in 11 the diagnosis was made antemortem by lung aspirate or biopsy, and in five the diagnosis was made at postmortem by typical lung histology and positive viral lung cultures. all patients were immunosuppressed by both their underlying diseases and treatment with corticosteroids and other chemotherapy. although other pathogens were identified at lung biopsy in most patients (73 per cent), primarily pneumocystis carinii, ev ...	1976	183499
[infectious complications observed during the use of antimitotic agents in hematology].	during acute lymphoblastic leukemia in children, bacterial infections occur during initial treatment, whereas virus infections are observed during remission. mycoses and pneumocystis carinii infections are the commonest late complications. during agranulocytosis, any prolonged fever should be considered as due to infection and probably septicemia. the bacteria are usually of digestive origin. antibiotic therapy is only very inconstantly efficacious, and the course follows closely the number of g ...	1976	185705
signs, symptoms, and pathophysiology of pneumocystis carinii pneumonitis.	in 80 patients with pneumocystis pneumonitis, the intial signs and symptoms of infection were usually fever and cough, followed by tachypnea and coryza. flaring of the nasal alae and cyanosis occurred later. blood gas composition was markedly altered in its acid-base profile in most patients at admission. there was moderate to severe respiratory alkalosis and hypoxia. clinical manifestations were correlated with the extent of histopathologic changes in the lung. (deprivation of protein in the di ...	1976	14304