Publications

TitleAbstractYear(sorted ascending)
Filter
PMID
Filter
distribution and corticosteroid regulation of glucocorticoid receptor in the brain of xenopus laevis.glucocorticoids (gcs) play essential roles in physiology, development, and behavior that are mediated largely by the glucocorticoid receptor (gr). although the gr has been intensively studied in mammals, very little is known about the gr in nonmammalian tetrapods. we analyzed the distribution and gc regulation of gr in the brain of the frog xenopus laevis by immunohistochemistry. gr-immunoreactive (gr-ir) cells were widely distributed, with the highest densities in the medial pallium (mp; homolo ...200818399546
sex differences in brain developing in the presence or absence of gonads.brain sexual differentiation results from the interaction of genetic and hormonal influences. this study used a unique agonadal mouse model to determine relative contributions of genetic and gonadal hormone influences in the differentiation of selected brain regions. sf-1 knockout (sf-1 ko) mice are born without gonads and adrenal glands and are not exposed to endogenous sex steroids during fetal/neonatal development. consequently, male and female sf-1 ko mice are born with female external genit ...200818418875
how often are potential patient safety events present on admission?data fields that capture whether diagnoses are present on admission (poa)--distinguishing comorbidities from potential in-hospital complications--became part of the uniform bill for hospital claims in 2007. the ahrq patient safety indicators (psis) were initially developed as measures of potential patient safety problems that use routine administrative data without poa information. the impact of adding poa information to psis was examined.200818419045
two challenges for here and now. grappling with rac and poa requirements. 200818421997
ipsilateral and contralateral serotonergic projections from dorsal and median raphe nuclei to the forebrain in rats: immunofluorescence quantitative analysis.the objective of this study was to clarify the 5-ht projections from the right and left sides of the dorsal (drd), ventral (drv) and lateral (drl) subdivisions of the middle level of the dorsal (dr) raphe nucleus and median (mr) raphe nucleus to the lateral septum (ls), preoptic area (poa) or ventromedial hypothalamus (vmh), which are important neural substrates for neuroendocrine regulation of reproduction. a retrograde neural tracer, fluoro-gold (fg), was infused into the right side of these r ...200818423675
can fine particulate matter explain the paradoxical ozone associations?our previous paper entitled "paradoxical ozone associations could be due to methyl nitrite from combustion of methyl ethers or esters in engine fuels" (env. int.. 2007;33;1090) reviewed 11 studies of the impact of ozone on human health that, paradoxically, found a negative coefficient for ozone-morbidity associations. we argued that the most likely explanation for this effect would be methyl nitrite (mn) as an unsuspected exhaust component of engines with methyl ether in the fuel. the basis of t ...200818430471
do the ahrq patient safety indicators flag conditions that are present at the time of hospital admission?the agency for healthcare research and quality (ahrq) developed 20 patient safety indicators (psis) to identify potentially preventable complications of acute inpatient care based on administrative data. the objective of this patient safety performance study was to assess the impact of cases flagged by each psi for diagnoses that were actually present on admission on unadjusted psi rates.200818438200
neonatal stimulation of 5-ht(2) receptors reduces androgen receptor expression in the rat anteroventral periventricular nucleus and sexually dimorphic preoptic area.masculinization of the brain is dependent upon a perinatal surge in testosterone. it also requires a transient decrease in hypothalamic 5-ht concentration and turnover and an increase in androgen receptor (ar) expression during the second postnatal week. we have previously shown that increasing 5-ht activity over this period in male or androgenized female rats feminizes their adult behaviour and also feminizes the size of their anteroventral periventricular nucleus (avpv) and sexually dimorphic ...200818445234
studies on land application of sewage sludge and its limiting factors.field experiments were conducted to study the effect of sewage sludge application on the heavy metal content in soils and grasses. the sewage sludge was obtained from northern shenyang wastewater treatment plant, china, and applied at 0, 15, 30, 60, 120 and 150tha(-1). native grasses zoysia japonica and poa annua were chosen as experimental plants. the experimental results showed that nutrient content of the soil, especially organic matter, was increased after sewage sludge application. the gras ...200818456400
impact of livestock grazing on abundance of miridae and reduviidae (hemiptera) in crested wheatgrass pastures.miridae of the genera labops and irbisia, collectively referred to as "black grass bugs," can cause significant damage to wheatgrasses (poaceae) of several genera on western north american rangeland. another mirid in the same area, capsus cinctus (kolenati), causes damage to bluegrass (poa spp.). previous studies suggest that grazing management may reduce mirid populations on rangeland by eliminating preferred oviposition sites and reducing accumulations of litter that provide diurnal refuges fo ...200818459393
central pathway for spontaneous and prostaglandin e2-evoked cutaneous vasoconstriction.a reduction of heat loss to the environment through increased cutaneous vasoconstrictor (cvc) sympathetic outflow contributes to elevated body temperature during fever. we determined the role of neurons in the dorsomedial hypothalamus (dmh) in increases in cvc sympathetic tone evoked by pge2 into the preoptic area (poa) in chloralose/urethane-anesthetized rats. the frequency of axonal action potentials of cvc sympathetic ganglion cells recorded from the surface of the tail artery was increased b ...200818463193
for poa, put focus on patient care not billing. 200818472721
quantification of seed oil from species with varying oil content using supercritical fluid extraction.the quantity and composition of seed oil affects seed viability and storability and hence the value of a species as a resource for nutrition and plant conservation. supercritical fluid extraction with carbon dioxide (sfe-co2) offers a rapid, environmentally friendly alternative to traditional solvent extraction.200818473329
regulation of pseudosexual behavior in the parthenogenetic whiptail lizard, cnemidophorus uniparens.neuroendocrine mechanisms underlying complementary behaviors like male-typical mounting and female-typical receptivity are most often studied independently in males and females, respectively. cnemidophorus uniparens is a unisexual lizard species consisting only of females that alternately express male- and female-like pseudosexual behavior across the ovarian cycle. intact, postovulatory (postov), and ovariectomized (ovx), androgen-implanted animals [ovx plus testosterone (t)] exhibit male-like m ...200818483155
an epidemiological study of the perception of asthenia by oncologists in cancer patients: poa study.despite the high prevalence of asthenia in cancer patients, around 50-75%, and its impact on quality of life, it continues to be a difficult symptom to assess and manage. this study defines the extent of perception and diagnosis of asthenia associated with cancer among spanish oncologists.200818490246
nell2 participates in formation of the sexually dimorphic nucleus of the pre-optic area in rats.formation of the sexually dimorphic nucleus of the pre-optic area (sdn-poa) in the rat hypothalamus shows a sexually differential development of neurons. volume of the sdn-poa in males is much bigger than that in females which is because of a neuroprotective effect of estradiol converted from circulating testosterone during a critical period of brain development. we found that neural epidermal growth factor-like like-2 (nell2), a neural tissue-enriched protein, is a potential downstream target o ...200818513367
seabream gnrh immunoreactivity in brain and pituitary of xx and xy nile tilapia, oreochromis niloticus during early development.seabream gonadotropin-releasing hormone (sbgnrh)-the chief preoptic area-hypothalamus (poa-h) form of gnrh in tilapia is involved in sexual maturation. in this study, we investigated the qualitative changes in ontogeny of sbgnrh immunoreactivity (ir-), between sexes to understand its impending role during sex differentiation. for this, the differences in immunocytochemical localization of sbgnrh in genetically male (xy) and female (xx) fish were studied from 1 day after hatching (dah), through t ...200818521911
does autoimmunity play a role in the pathophysiology of premature ovarian ageing?to determine a possible causative association between autoimmunity and premature ovarian ageing (poa), 394 women undergoing ivf at an academically affiliated private ivf centre were retrospectively evaluated for the presence of autoimmune-related diseases. out of 162 poa women, 13 (8.0%) demonstrated a history of autoimmune disease(s), while autoimmunity was present in 28 (12.1%) of 232 controls. poa women with poor response (four oocytes or fewer) despite high-dose treatment presented autoimmun ...200818549693
affinity capture of uropathogenic escherichia coli using pigeon ovalbumin-bound fe3o4@al2o3 magnetic nanoparticles.escherichia coli and staphylococcus saprophyticus are the most common causes of urinary tract infections, with 80% of these infections caused by uropathogenic e. coli. because the p fimbriae of e. coli have specificity toward gal(alpha1-4)gal beta units, pigeon ovalbumin (poa), whose structure contains terminal gal(alpha1-4)gal beta moieties, was used as a probe for interaction with p fimbriated e. coli. the functional affinity probes for these bacteria by immobilizing poa--a phosphoprotein--ont ...200818553981
orphanin fq and glutamate connection in the regulation of gonadotropin-releasing hormone secretion in the preoptic area of conscious male rats.utilizing the method of push-pull perfusion and radioimmunoassay (ria), the secretory profile of gonadotropin-releasing hormone (gnrh) in the preoptic area (poa) and serum-luteinizing hormone (lh) levels were examined in conscious male rats after administration of [nphe(1)]nc(1-13)nh(2), a competitive antagonists of the opioid receptor-like 1 receptor (orl1 receptor) which is endogenous receptor for orphanin fq (ofq). glutamate release in the poa was also measured by high-performance liquid chro ...200818562103
effects of grass silage and soybean meal supplementation on milk production and milk fatty acid profiles of grazing dairy cows.the effects of supplementation with grass silage and replacement of some corn in the concentrate with soybean meal (sbm) on milk production, and milk fatty acid (fa) profiles were evaluated in a replicated 4 x 4 latin square study using 16 dairy cows grazing pasture composed of ryegrass, kentucky bluegrass, and white clover. each experimental period lasted for 3 wk. the 4 dietary treatments were pc, 20 h of access to grazing pasture, supplemented with 6 kg/d of corn-based concentrate mixture (96 ...200818565932
mango: multiple alignment with n gapped oligos.multiple sequence alignment is a classical and challenging task. the problem is np-hard. the full dynamic programming takes too much time. the progressive alignment heuristics adopted by most state-of-the-art works suffer from the "once a gap, always a gap" phenomenon. is there a radically new way to do multiple sequence alignment? in this paper, we introduce a novel and orthogonal multiple sequence alignment method, using both multiple optimized spaced seeds and new algorithms to handle these s ...200818574861
poor attentional function predicts cognitive decline in patients with non-demented parkinson's disease independent of motor phenotype.postural instability gait difficulty (pigd) motor phenotype in parkinson's disease (pd) is associated with a faster rate of cognitive decline than in tremor dominant cases and may be a risk factor for incident dementia. people with pd display attentional deficits; however, it is not clear whether attentional deficits in patients with non-demented pd are associated with (i) pigd phenotype and/or (ii) subsequent cognitive decline.200818586866
neural substrates for sexual preference and motivation in the female and male rat.rodents identify a mating partner by using olfactory cues. female rats in estrus spend a longer time sniffing odors of sexually active males when physical contacts are hampered. sexually active males are attracted by odors of receptive females. the preference in either sex disappears when the subjects are gonadectomized, an effect reversible by supplement with estrogen or testosterone. thus, circulating sex steroids determine the odor preference in both sexes. in both sexes, olfactory cues get t ...200818591469
sex and seasonal differences in morphology of limbic forebrain nuclei in the green anole lizard.sex and seasonal differences in the brain occur in many species and are often related to behavioral expression. for example, morphology of limbic regions involved in male sex behavior are larger in males than in females, and sometimes are larger in the breeding than non-breeding season. morphology can often be altered in adulthood by manipulating levels of steroid hormones. in untreated green anole lizards, previous work indicated that neuron soma size and density did not differ between the sexe ...200818598684
analysis of poa and hospital-acquired conditions data. part 1. 200818604981
o/c and om/oc ratios of primary, secondary, and ambient organic aerosols with high-resolution time-of-flight aerosol mass spectrometry.a recently developed method to rapidly quantify the elemental composition of bulk organic aerosols (oa) using a high-resolution time-of-flight aerosol mass spectrometer (hr-tof-ams) is improved and applied to ambient measurements. atomic oxygen-to-carbon (o/c) ratios characterize the oxidation state of oa, and o/c from ambient urban oa ranges from 0.2 to 0.8 with a diurnal cycle that decreases with primary emissions and increases because of photochemical processing and secondary oa (soa) product ...200818605574
nonclassical mechanisms of progesterone action in the brain: ii. role of calmodulin-dependent protein kinase ii in progesterone-mediated signaling in the hypothalamus of female rats.in addition to the activation of classical progestin receptor-dependent genomic pathway, progesterone (p) can activate nonclassical, membrane-initiated signaling pathways in the brain. we recently demonstrated rapid p activation of second-messenger kinases, protein kinase a, and protein kinase c in the ventromedial nucleus (vmn) and preoptic area (poa) of rat brain. to determine whether p can activate yet another ca+2 dependent kinase, we examined the rapid p modulation of calcium and calmodulin ...200818617607
nonclassical mechanisms of progesterone action in the brain: i. protein kinase c activation in the hypothalamus of female rats.the modulation of gene regulation by progesterone (p) and its classical intracellular regulation by progestin receptors in the brain, resulting in alterations in physiology and behavior has been well studied. the mechanisms mediating the short latency effects of p are less well understood. recent studies have revealed rapid nonclassical signaling action of p involving the activation of intracellular signaling pathways. we explored the involvement of protein kinase c (pkc) in p-induced rapid sign ...200818617608
characterization and in vitro degradation of poly(octadecanoic anhydride).poly(octadecanoic anhydride) (poa) has been prepared by melt polycondensation of octadecanoic diacid. poa was characterized by fourier-transform infrared spectroscopy (ftir), differential scanning calorimetry (dsc) and wide angle x-ray diffraction (waxd). the results of in vitro degradation and sem micrographs show that the erosion process of poa is neither bulk nor perfect surface erosion but rather has elements of both in phosphate buffer at 37 degrees c. the moving erosion front is characteri ...200817577635
suffer the little children: fixed intraoral habit appliances for treating childhood thumbsucking habits: a critical review of the literature.a critical review of the literature is presented covering the treatment of childhood thumbsucking habits using fixed intraoral habit appliances (hayrake, palatal crib). the habit appliances are classified into type and function. data is tabulated for key references revealing the fragmented and distorted nature of the literature and its lack of consistency. a chronological approach is presented to confirm the confused and idiosyncratic character of the literature. information is provided on the e ...200819545090
improvement of cognitive test performance in patients undergoing primary cabg and other cpb-assisted cardiac procedures.cardiac surgical procedures assisted by cardiopulmonary bypass (cpb) impair cognitive functions. several studies, however, showed that cognitive functions were unaffected in patients undergoing either primary coronary artery bypass grafting (cabg) or more complex surgery assisted by cpb. therefore, we conducted a straightforward study to compare patient groups who differed significantly in terms of risk factors such as prolonged cpb times. consecutive patients (n = 54) were included, undergoing ...200819346264
food and feeding preferences of himalayan gray goral (naemorhedus goral bedfordi) in pakistan and azad jammu and kashmir.himalayan gray goral is endemic to himalayas and hindukush ranges. analysis of 15 fecal samples and field observations from different areas of pakistan and azad kashmir suggest that goral consumes foliage of a minimum of 28 plant species. trees, shrubs and grasses appear in the ratio of 1:36:63 and hence the species is a grazer, though may opt for browsing when forced. the species mainly subsists on six species of grasses (chrysopogon aucheri=17.97%, themeda anathera=13.03%, poa pratensis=11.23% ...200819360631
distribution, biology and pathology of anguina pacificae.anguina pacificae is distributed along a narrow strip on the pacific coast of northern california where it forms galls on the shoots of poa annua and causes significant damage to golf course greens. methods were developed for the continuous propagation of a. pacificae on p. annua in growth chambers, and they were used to examine the life cycle and host-parasite relationships of the nematode. at a mean temperature of 20 degrees c (22 degrees c day/18 degrees c night) the life cycle was completed ...200819440264
water deficit and induction of summer dormancy in perennial mediterranean grasses.summer dormancy is a trait conferring superior drought survival in mediterranean perennial grasses. as the respective roles of environmental factors and water deficit on induction of summer dormancy are unclear, the effect of intense drought were tested under contrasting day lengths in a range of forage and native grasses.200919369219
discrepancy between admission and discharge diagnoses as a predictor of hospital length of stay.the addition of clinical data or present on admission (poa) codes to administrative databases improves the accuracy of predicting clinical outcomes, such as inpatient mortality. other poa information may also explain variation in hospital outcomes, such as length of stay (los), but this potential has not been previously explored.200919388065
use of disposed waste ash from landfills to replace portland cement.in this study, waste ash was utilized as a pozzolanic material in blended portland cement in order to reduce negative environmental effects and landfill volume required to dispose of waste ash. the influence of waste ash, namely palm oil fuel ash, rice husk ash and fly ash on compressive strength and sulfate resistance in mortar were studied and evaluated by some accelerated short-term techniques in sodium sulfate solutions. ordinary portland cement (opc) was partially replaced with ground palm ...200919423600
characterization and mapping of sleep-waking specific neurons in the basal forebrain and preoptic hypothalamus in mice.we recorded 872 single units across the complete sleep-waking cycle in the mouse preoptic area (poa) and basal forebrain (bfb), which are deeply involved in the regulation of sleep and wakefulness (w). of these, 552 were sleep-active, 96 were waking-active, 106 were active during both waking and paradoxical sleep (ps), and the remaining 118 were state-indifferent. among the 872, we distinguished slow-wave sleep (sws)-specific, sws/ps-specific, ps-specific, w-specific, and w/ps-specific neurons, ...200919285545
different populations of prostaglandin ep3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions.the central mechanism of fever induction is triggered by an action of prostaglandin e(2) (pge(2)) on neurons in the preoptic area (poa) through the ep3 subtype of prostaglandin e receptor. ep3 receptor (ep3r)-expressing poa neurons project directly to the dorsomedial hypothalamus (dmh) and to the rostral raphe pallidus nucleus (rrpa), key sites for the control of thermoregulatory effectors. based on physiological findings, we hypothesize that the febrile responses in brown adipose tissue (bat) a ...200919327390
mineral concentration in selected native temperate grasses with potential use as biofuel feedstock.stands of native grasses along roadways, in buffer strips, riparian zones and grass prairies have potential utility as feedstock for bioenergy production. the sustainability of harvesting these stands is reliant, in part, on knowledge of the mineral concentration of the harvested grasses because removal of mineral nutrients such as phosphorus (p) and potassium (k) can impact subsequent biomass production and ecosystem services associated with these stands. mineral content of biomass, particularl ...200919329307
mass spectrometric investigation of molecular variability of grass pollen group 1 allergens.natural grass pollen allergens exhibit a wide variety of isoforms. precise characterization of such microheterogeneity is essential to improve diagnosis and design appropriate immunotherapies. moreover, standardization of allergen vaccine production is a prerequisite for product safety and efficiency. both qualitative and quantitative analytical methods are thus required to monitor and control the huge natural variability of pollens, as well as final product quality. a proteomic approach has bee ...200919572759
audio-visual identification of place of articulation and voicing in white and babble noise.research shows that noise and phonetic attributes influence the degree to which auditory and visual modalities are used in audio-visual speech perception (avsp). research has, however, mainly focused on white noise and single phonetic attributes, thus neglecting the more common babble noise and possible interactions between phonetic attributes. this study explores whether white and babble noise differentially influence avsp and whether these differences depend on phonetic attributes. white and b ...200919603894
pyrethroid resistance mediated by enzyme detoxification in listronotus maculicollis (coleoptera: curculionidae) from connecticut.in 2009, pyrethroid resistance was confirmed for seven "annual bluegrass weevil" listronotus maculicollis kirby (coleoptera: curculionidae) adult populations from southern new england. the mechanisms responsible for conferring this resistance were unknown. in this study, topical application bioassays with bifenthrin and bifenthrin combined with synergists affecting three detoxification systems were conducted on four field-collected adult populations of l. maculicollis from connecticut to determi ...200919610439
development of binomial sequential sampling plans for forecasting listronotus maculicollis (coleoptera: curculionidae) larvae based on the relationship to adult counts and turfgrass damage.binomial sequential sampling plans were developed to forecast weevil listronotus maculicollis kirby (coleoptera: curculionidae), larval damage to golf course turfgrass and aid in the development of integrated pest management programs for the weevil. populations of emerging overwintered adults were sampled over a 2-yr period to determine the relationship between adult counts, larval density, and turfgrass damage. larval density and composition of preferred host plants (poa annua l.) significantly ...200919610454
do etiologies of premature ovarian aging (poa) mimic those of premature ovarian failure (pof)?it is unknown whether etiologies differ between milder forms of premature ovarian senescence (the acronym given here 'premature ovarian aging, poa'), and premature ovarian failure (pof).200919617205
the anti-dopaminergic agent, haloperidol, antagonises the feminising effect of neonatal serotonin on sexually dimorphic hypothalamic nuclei and tyrosine hydroxylase immunoreactive neurones.there is a transient fall in hypothalamic serotonin (5-hydroxytryptamine; 5-ht) activity in the second week post partum in male but not female rats. when this fall is masked by administration of the 5-ht(2) agonist (-) 2,5-dimethoxy-4-iodophenyl]-2-aminopropane hydrochloride [(-)doi], over days 8-16 post partum, males are feminised in adulthood. to investigate whether the effect of 5-ht is mediated by dopamine and whether testosterone exerts its masculinising effect by reducing 5-ht and dopamine ...200919453825
[responses of subalpine meadow poa botryoides to climate change].based on the field plot observation and related meteorological data, the effects of climate change in 1985-2005 on the growth and development of subalpine meadow poa botryoides in maqu county of gansu province were analyzed. the results showed that during study period, the annual precipitation in the maqu county had a decreasing trend, with a rate of -9.895 mm x (10 a)(-1) and a cycle of 3 years, while the annual air temperature had an increasing trend, with a rate of 0.341 degrees c x (10 a)(-1 ...200919459365
medicare's value-based payment initiatives: impact on and implications for improving physician documentation and coding.medicare has introduced a number of new payment initiatives that will have a profound effect on hospital reimbursement and quality and safety ratings. the new medical severity diagnosis-related group (ms-drg) payment system adds a number of new drg categories to more adequately account for patient severity. the new present-on-admission (poa) initiative is designed to withhold additional reimbursement for selected complications that were not recorded as being poa but that occurred during the cour ...200919461068
heat loss responses and blockade of prostaglandin e2-induced thermogenesis elicited by alpha1-adrenergic activation in the rostromedial preoptic area.the unilateral microinjection of noradrenaline (na), but not vehicle solution, into the rostromedial preoptic area (poa) elicited simultaneous increases in cutaneous temperatures of the tail and sole of the foot and decreases in the whole-body o(2) consumption rate, heart rate, and colonic temperature in urethane-chloralose-anesthetized rats, suggesting a coordinate increase in heat loss and decrease in heat production. the magnitude of these responses increased dose-dependently over the range o ...200919465086
gonadotrophin-releasing hormone and gnrh-associated peptide neurobiology from the rearing period until puberty in the female sheep.using morphological criteria we describe the postnatal ontogeny of gonadotrophin-releasing hormone (gnrh) and gnrh-associated peptide (gap) of the gnrh prohormone in the ovine preoptic area (poa)-hypothalamus. the immunohistochemical gnrh- and gap-neuroanatomy was investigated in infantile (12-week-old weanlings), prepubertal (15-, 22-week-old juveniles), peripubertal (30-, 52-week-old during maturational quiescence) and pubertal (63-week-old) females born after the summer solstice, thus undergo ...200919465112
sexually dimorphic estrogen receptor alpha mrna expression in the preoptic area and ventromedial hypothalamus of green anole lizards.estradiol (e2) is important in activation of male reproductive behaviors, and masculinizes morphology of associated brain regions in a number of mammalian and avian species. in contrast, it is testosterone, rather than its metabolites, that is the most potent activator of male sexual behavior in green anole lizards. as in other vertebrate groups, however, e2 is critical for receptivity in females of this species. aromatase, the enzyme which converts testosterone to e2, is more active in the male ...200919470372
effects of intrauterine 2,3,7,8-tetrachlorodibenzo-p-dioxin on the development and function of the gonadotrophin releasing hormone neuronal system in the male rat.2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is an environmental disrupter that continues to be generated from numerous industrial processes. in utero and lactational exposure of rats to levels of tcdd similar to those encountered by human populations have profound and persistent effects on growth, the reproductive axis and spatial learning and memory. tcdd is thought to act through the aryl hydrocarbon receptor, which displays crosstalk with estrogen-mediated genomic activation. an in vitro super ...200919490993
lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against m. tuberculosis.pyrazinamide (pza) is active against m. tuberculosis and is a first line agent for the treatment of human tuberculosis. pza is itself a prodrug that requires activation by a pyrazinamidase to form its active metabolite pyrazinoic acid (poa). since the specificity of cleavage is dependent on a single bacterial enzyme, resistance to pza is often found in tuberculosis patients. esters of poa have been proposed in the past as alternatives to pza however the most promising compounds were rapidly degr ...200919491013
the role of parliamentarians in promoting sexual and reproductive health and rights.parliamentarians are central to the full implementation of the international conference on population and development programme of action (icpd poa). we promote, review, and adopt sexual and reproductive health and rights (srhr) legislation, including budget appropriations. parliamentarians also approve policies formulated by government and endorse resolutions and statements in support of srhr. all party parliamentary groups on population, development, and reproductive health have now been estab ...200919535070
phylogenetic divergence, morphological and physiological differences distinguish a new neotyphodium endophyte species in the grass bromus auleticus from south america.the fungi of genus neotyphodium are systemic, constitutive, symbionts of grasses of subfamily pooideae. in the southern hemisphere most of these asexual endophytes are the result of the hybridization between two sexual species, epichlo" festucae and e. typhina, from the northern hemisphere. however the ancestral sexual species have not been detected in this region. several grasses from argentina are infected by neotyphodium species. these endophytes are in general very similar macro- and micromo ...200919537207
in vitro cross-reactivity between tomato and other plant allergens.cross-reactivity among fruits and different pollen and fruit species has been extensively reported.200919927542
development of a validation algorithm for 'present on admission' flagging.the use of routine hospital data for understanding patterns of adverse outcomes has been limited in the past by the fact that pre-existing and post-admission conditions have been indistinguishable. the use of a 'present on admission' (or poa) indicator to distinguish pre-existing or co-morbid conditions from those arising during the episode of care has been advocated in the us for many years as a tool to support quality assurance activities and improve the accuracy of risk adjustment methodologi ...200919951430
immunological characterization and distribution of three gnrh forms in the brain and pituitary gland of chub mackerel (scomber japonicus).the presence of three gonadotropin-releasing hormone (gnrh) forms in the brain of the chub mackerel, scomber japonicus, namely, salmon gnrh (sgnrh), chicken gnrh-ii (cgnrh-ii), and seabream gnrh (sbgnrh), was confirmed by combined high performance liquid chromatography (hplc) and time-resolved fluoroimmunoassay (tr-fia). immunocytochemical localization of the three gnrh forms in the brain was investigated by using specific antisera, to elucidate possible roles of each gnrh form in reproduction i ...200919968470
persistent primitive olfactory artery aneurysm.a hypertensive 69-year-old man presented with an incidentally discovered non-ruptured aneurysm of the persistent primitive olfactory artery (poa). the poa originates at the terminal portion of the internal carotid artery, runs along the olfactory tract anteriorly toward the crista galli, and forms an acute angle with the distal anterior cerebral artery. the aneurysm was located at this characteristic acute angle. the persistent poa aneurysm associated with an anterior communicating artery aneury ...200919633402
motherhood and nursing stimulate c-fos expression in the rabbit forebrain.mother rabbits nurse once daily with circadian periodicity. the authors investigated brain structures involved in regulating this activity by quantifying c-fos-immunoreactive (ir) cells in the forebrain of: (1) mothers killed on postpartum day 1 (ppd 1) after nursing (group 1) or not given pups (group 2); (2) mothers killed on ppd 7 after nursing (group 3) or not given pups on such day (group 4); (3) unmated virgins (group 5). groups 1 through 4 showed similar numbers of c-fos-ir cells in the pr ...200919634930
using a selectivity index to evaluate logarithmic spraying in grass seed crops.grass seed crops are minor crops that cannot support the development of selective herbicides for grass weed control in grass seed crops. an option is to screen for selective herbicides with the use of logarithmic spraying technology. the aim of this paper is to assess selectivity of various herbicides in grass seed crops by using dose-response curves.200919655396
simulating the formation of semivolatile primary and secondary organic aerosol in a regional chemical transport model.recent developments in our understanding of atmospheric organic particulate matter formation have been used to develop a state-of-the-art organic aerosol module for regional chemical transport models (ctms). the module has been added to the regional ctm, pmcamx, and has been evaluated against observations in the eastern u.s. the new module uses the volatility basis set framework to simulate primary organic aerosol (poa) partitioning between the gas and particulate phases and the gas-phase oxidat ...200919673257
constraining the volatility distribution and gas-particle partitioning of combustion aerosols using isothermal dilution and thermodenuder measurements.the gas-particle partitioning of primary organic aerosol (poa) emissions from a diesel engine and the combustion of hard- and soft-woods in a stove was investigated by isothermally diluting them in a smog chamber or by passing them through a thermodenuder and measuring the extent of evaporation. the experiments were conducted at atmospherically relevant conditions: low concentrations and small temperature perturbations. the partitioning of the poa emissions from both sources varied continuously ...200919673261
noradrenaline involvement in the negative-feedback effects of ovarian steroids on luteinising hormone secretion.noradrenaline has been shown to modulate the ovarian-steroid feedback on luteinising-hormone (lh) release. however, despite the high amount of evidence accumulated over many years, the role of noradrenaline in lh regulation is still not clearly understood. the present study aimed to further investigate the involvement of noradrenaline in the negative-feedback effect of oestradiol and progesterone on basal lh secretion. in experiment 1, ovariectomised (ovx) rats received a single injection of oil ...200919686440
c-fos expression in preoptic nuclei as a marker of sleep rebound in the rat.thermoregulation is known to interfere with sleep, possibly due to a functional interaction at the level of the preoptic area (poa). exposure to low ambient temperature (t(a)) induces sleep deprivation, which is followed by sleep rebound after a return to laboratory t(a). as two poa subregions, the ventrolateral preoptic nucleus (vlpo) and the median preoptic nucleus (mnpo), have been proposed to have a role in sleep-related processes, the expression of c-fos and the phosphorylated form of the c ...200919686475
premier/ihi algorithms automate process for identifying patient harm.no recognized standard for determining harm currently exist. harm data can be used to improve quality of care. accurate poa coding is critical to get true picture of patient harm.200919697805
chemically-resolved volatility measurements of organic aerosol fom different sources.a newly modified fast temperature-stepping thermodenuder (td) was coupled to a high resolution time-of-flight aerosol mass spectrometer for rapid determination of chemically resolved volatility of organic aerosols (oa) emitted from individual sources. the td-ams system was used to characterize primary oa (poa) from biomass burning, trash burning surrogates (paper and plastic), and meat cooking as well as chamber-generated secondary oa (soa) from alpha-pinene and gasoline vapor. almost all atmosp ...200919708365
giant cavernous aneurysm associated with a persistent trigeminal artery and persistent otic artery.primitive trigeminal artery (pta) and primitive otic artery (poa) is a very rare entity in adult life. we present a case of pta and poa associated with a giant unruptured cavernous aneurysm in a 54-year-old woman. the pta and the poa arose from the sac of the aneurysm directly, which greatly complicated endovascular therapy management.200919721839
brassicaceae tissues as inhibitors of nitrification in soil.brassicaceae crops often produce an unexplained increase in plant-available soil n possibly related to bioactive compounds produced from glucosinolates present in the tissues. our objective was to determine if glucosinolate-containing tissues inhibit nitrification, thereby potentially explaining this observation. ammonium, no(2)(-), and no(3)(-) n were measured in soils amended with brassicaceae ( isatis tinctoria l., brassica napus l., brassica juncea l., and sinapis alba l.) tissues containing ...200919722704
sex-specific modulation of cell proliferation by socially relevant stimuli in the adult green treefrog brain (hyla cinerea).social experience plays an important role in regulating the neural, physiological and hormonal changes that accompany the expression of reproductive behavior in vertebrates. this suite of functions is sexually dimorphic, with different neural control areas preeminent in males and females. in anuran amphibians, social experience comes in the form of acoustic communication, which is central to their reproductive behavior. we sought to determine whether acoustic cues regulate cell proliferation in ...200919729900
anatomical localization of the effects of reproductive state, castration, and social milieu on cells immunoreactive for gonadotropin-releasing hormone-i in male european starlings (sturnus vulgaris).gonadotropin-releasing hormone-i (gnrh-i) cells are localized primarily to the septopreoptic area (poa) and are responsible for regulating gonadotropin release from the anterior pituitary. some songbird species exhibit dramatic seasonal variation in the number of detectable gnrh-i immunoreactive cells, with higher numbers being observed during the breeding season. here we investigated the anatomical distribution of gnrh-i-immunoreactive cells in male starlings that varied in response to manipula ...200919731303
dopamine agonist signalling in the hypothalamus of female rats is independent of calcium-dependent kinases.we have previously demonstrated that dopamine agonist, skf38396 (skf), can substitute for progesterone in the facilitation of female reproductive behaviour in oestradiol benzoate-primed female rats and mice. we also reported that both progesterone- and skf-initiated signalling were mediated by the camp-dependent protein kinase a signal transduction cascade. as the rapid effects of progesterone are also mediated by calcium-dependent kinases, calcium- and calmodulin-dependent kinase (camkii) and p ...200919732294
identification of pseudomonas aeruginosa using functional magnetic nanoparticle-based affinity capture combined with maldi ms analysis.pa-il is a galactophilic lectin that is found on the outer membrane of pseudomonas aeruginosa. pigeon ovalbumin (poa), a phosphoprotein, contains high levels of terminal gal alpha(1-->4)gal units. thus, magnetic nanoparticles with immobilized poa can be used as affinity probes for p. aeruginosa, functioning via the recognition of galactophilic pa-il. we fabricated poa-bound nanoparticles (nps) by immobilizing poa onto the surface of core/shell magnetic iron oxide/alumina nps via metal-phosphate ...200919768218
evaluation of molecular basis of cross reactivity between rye and bermuda grass pollen allergens.allergenic cross reactivity between the members of the pooids (lolium perenne, phleum pratense, and poa pratensis) and chloridoids (cynodon dactylon and paspalum notatum) is well established. studies using crude extracts in the past have demonstrated limited cross reactivity between the pooids and the chloridoids suggesting separate diagnosis and therapy. however, little is known regarding the molecular basis for the limited cross reactivity observed between the 2 groups of grasses. the present ...200919776679
synthesis of poly(o-anisidine)/h(2)so(4) film for the development of glucose biosensor.the poly(o-anisidine)-sulfuric acid-glucose oxidase (poa-h(2)so(4)-gox) electrode has been investigated in the present work. platinum electrode was used for the synthesis of poly (o-anisidine)-sulfuric acid (poa-h(2)so(4)) film using galvanostatic method with 0.2 m o-anisidine, 1.0 m h(2)so(4) solution, 1.0 ph and 2 ma/cm(2) applied current density. the synthesized film was characterized using electrochemical technique, conductivity measurement, uv-visible spectroscopy, fourier transform infrare ...200919802711
central role of traf-interacting protein in a new model of brain sexual differentiation.sexually dimorphic brain nuclei underlie gender-specific neural functions and susceptibility to disease, but the developmental basis of dimorphisms is poorly understood. in these studies, we focused on the anteroventral periventricular nucleus (avpv), a nucleus that is larger in females and critical for the female-typical cyclic surge pattern of luteinizing hormone (lh) release. sex differences in the size and function of the avpv result from apoptosis that occurs preferentially in the developin ...200919805359
phytoremediation of metal-contaminated soil in temperate humid regions of british columbia, canada.the suitability of five plant species was studied for phytoextraction and phytostabilisation in a region with temperate maritime climate of coastal british columbia, canada. pot experiments were conducted using lolium perenne l (perennial rye grass), festuca rubra l (creeping red fescue), helianthus annuus l (sunflower), poa pratensis l (kentucky bluegrass) and brassica napus l (rape) in soils treated with three different metal (cu, pb, mn, and zn) concentrations. the bio-metric characters of pl ...200919810356
kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge.kisspeptin is the product of the kiss1 gene that regulates gnrh secretion. in sheep, kiss1 mrna-expressing cells are found in the preoptic area (poa) and arcuate nucleus (arc), and expression is up-regulated in the caudal arc during the periovulatory period. we hypothesized that kisspeptin neurons in the arc are activated by estradiol-17beta prior to the preovulatory lh surge. ovariectomized ewes were treated as follows: 1) estradiol-17beta implants (sc 2 wk) to cause tonic negative feedback; 2) ...200919819940
melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe.to further test the hypothesis that melanocortins stimulate the reproductive axis, we treated ewes with melanocortin agonist (mtii) in the luteal phase of the estrous cycle and during seasonal anestrus. lateral ventricular infusion of mtii (10 microg/h) during the luteal phase increased lh secretion. retrograde neuronal tracing in the brain showed few proopiomelanocortin or kisspeptin cells in the arcuate nucleus, but more than 70% of kisspeptin cells in the dorsolateral preoptic area (poa), pro ...200919819961
influence of ethynylestradiol and methyltestosterone on the hypothalamo-hypophyseal-gonadal axis of adult air-breathing catfish, clarias gariepinus.adult male and female air-breathing catfish clarias gariepinus were treated with ethynylestradiol (ee(2)) and methyltestosterone (mt) at concentrations of 1microg/l, respectively for 21 days. ee(2) treatment caused disappearance of spermatids/sperm from several testicular lumen/lobules in males while mt treatment to females led to precocious ovarian development. ee(2) caused significant fluid retention in all tissues including peritoneal cavity and seminal vesicles. immunocytochemical localizati ...200919836846
prostaglandin e2-induced masculinization of brain and behavior requires protein kinase a, ampa/kainate, and metabotropic glutamate receptor signaling.prostaglandin e(2) (pge(2)) mediates the masculinization of adult sex behavior in rats in response to the surge in serum testosterone at approximately birth. measures of behavioral masculinization correlate with a twofold increase in spinophilin protein and the density of dendritic spines in the medial preoptic area (poa). of the four receptors for pge(2), ep(2) and ep(4) are required for the masculinization of behavior by pge(2). ep(2) and ep(4) couple to g(s)-proteins, activating protein kinas ...200919846715
annual checkup: the cms pressure ulcer present-on-admission indicator.purpose: to provide the wound care practitioner with information about the centers for medicare and medicaid services (cms) pressure ulcer present-on-admission (poa) indicators. target audience: this continuing education activity is intended for physicians and nurses with an interest in skin and wound care. objectives: after reading this article and taking this test, the reader should be able to: 1. describe the history and rationale for the cms financial incentives for pressure ulcer (pru) prev ...200920026923
postmenopausal increase in kiss-1, gpr54, and luteinizing hormone releasing hormone (lhrh-1) mrna in the basal hypothalamus of female rhesus monkeys.the g-protein coupled receptor, gpr54, and its ligand, kisspeptin-54 (a kiss-1 derived peptide) have been reported to be important players in control of lhrh-1 release. however, the role of the gpr54 signaling in primate reproductive senescence is still unclear. in the present study we investigated whether kiss-1, gpr54, and lhrh-1 mrna in the brain change after menopause in female rhesus monkeys using quantitative real-time pcr. results indicate that kiss-1, gpr54, and lhrh-1 mrna levels in the ...200918619506
the anterolateral projections of the medial basal hypothalamus affect sleep.the role of the medial basal hypothalamus (mbh) and the anterior hypothalamus/preoptic area (ah/poa) in sleep regulation was investigated using the halász knife technique to sever mbh anterior and lateral projections in rats. if both lateral and anterior connections of the mbh were cut, rats spent less time in non-rapid eye movement sleep (nrems) and rapid eye movement sleep (rems). in contrast, if the lateral connections remained intact, the duration of nrems and rems was normal. the diurnal rh ...200919193940
identification of hospital-acquired catheter-associated urinary tract infections from medicare claims: sensitivity and positive predictive value.hospital-acquired catheter-associated urinary tract infection (cauti) is one of the first 6 conditions medicare is targeting to reduce payment associated with hospital-acquired conditions under congressional mandate. this study was to determine the positive predictive value (ppv) and sensitivity in identifying patients in medicare claims who had urinary catheterization and who had hospital-acquired cautis.200919194330
estradiol modulates behavioral arousal and induces changes in gene expression profiles in brain regions involved in the control of vigilance.estrogens reduce lipocalin-type prostaglandin d synthase (l-pgds) expression in a region-dependent manner in the mouse preoptic area (poa). this result linked sex hormones with sleep-wake cycle regulation. in turn, the somnogenic effects of prostaglandin d(2) have been shown to be mediated via increases in adenosine, and a select group of sleep-active ventrolateral preoptic nucleus (vlpo) neurons are directly activated by adenosine 2a (a(2a)) agonists. we hypothesized that increased arousal afte ...200919200066
effect of altitude on the genetic structure of an alpine grass, poa hiemata.the persistence of plants inhabiting restricted alpine areas under climate change will depend upon many factors including levels of genetic variation in adaptive traits, population structure, and breeding system.200919208670
developmental profiles of neuroendocrine gene expression in the preoptic area of male rats.reproductive function is controlled by gnrh cells and their steroid-sensitive regulatory inputs. the proper maturation of this system is critical to sexual development and maintenance of adult function. however, the molecular mechanisms underlying these developmental changes, and the potential roles of gonadal hormones in sculpting these processes, have not been fully explored. we performed a developmental profile from postnatal day (p) 1 through p60 of a network of five genes in the preoptic ar ...200919147677
cloning of gonadotropin-releasing hormone i complementary dnas in songbirds facilitates dissection of mechanisms mediating seasonal changes in reproduction.temperate zone animals exhibit seasonal variation in reproductive physiology. in most cases, seasonal changes in reproductive states are regulated by changes in gnrh1 secretion, rather than synthesis, from the preoptic area (poa)/anterior hypothalamus. an important exception occurs in some songbirds that become photorefractory to the stimulatory effects of long days and show profound decreases in brain gnrh1 protein content. whether this decline reflects changes in gene expression is unknown bec ...200919131568
frequent fire promotes diversity and cover of biological soil crusts in a derived temperate grassland.the intermediate disturbance hypothesis (idh) predicts that species diversity is maximized at moderate disturbance levels. this model is often applied to grassy ecosystems, where disturbance can be important for maintaining vascular plant composition and diversity. however, effects of disturbance type and frequency on cover and diversity of non-vascular plants comprising biological soil crusts are poorly known, despite their potentially important role in ecosystem function. we established replic ...200919132400
identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala.the development of the amygdala, a central structure of the limbic system, remains poorly understood. we found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. we found that dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. moreover, dbx1-derived cells comprise ...200919136974
age-related changes in hypothalamic androgen receptor and estrogen receptor alpha in male rats.the control of reproductive function involves actions of sex steroids upon their nuclear receptors in the hypothalamus and preoptic area (poa). whether hypothalamic hormone receptors change their expression in aging male mammals has not been extensively pursued, although such changes may underlie functional losses in reproductive physiology occurring with aging. we performed a stereologic analysis of immunoreactive androgen receptor (ar) and estrogen receptor alpha (eralpha) cells in three poa n ...200919051266
morphology and estrogen receptor alpha mrna expression in the developing green anole forebrain.sex differences in forebrain morphology arise during development and are often linked to hormonal changes. these dimorphisms frequently occur in regions related to reproductive behaviors. little is known about the normal ontogeny of reproductive nuclei in the green anole lizard, including whether steroid hormones influence their development. to address this issue, brain region volume, cell density, soma size, and estrogen receptor alpha (eralpha) mrna expression were characterized in the preopti ...200919065643
steroidogenic enzyme gene expression in the brain of the parthenogenetic whiptail lizard, cnemidophorus uniparens.the steroidogenic enzyme cyp17 is responsible for catalyzing the production of androgenic precursors, while cyp19 converts testosterone to estradiol. de novo neurosteroidogenesis in specific brain regions influences steroid hormone dependent behaviors. in the all-female lizard species cnemidophorus uniparens, individuals alternately display both male-like mounting and female-like receptivity. mounting is associated with high circulating concentrations of progesterone following ovulation (postov) ...200919084508
expression of leptin and long-form leptin-receptor proteins in porcine hypothalamus during oestrous cycle and pregnancy.in this study, we examined the levels of leptin and ob-rb protein expression in the discrete areas of the porcine hypothalamus (mediobasal hypothalamus--mbh, pre-optic area--poa, stalk median eminence--sme) during mid- and late-luteal phases of the oestrous cycle (days 10-12 and 14-16) as well as two stages of pregnancy (days 14-16 and 30-32). the analysis showed that during the cycle, leptin protein expression in mbh was higher in the mid-luteal phase than late-luteal phase. in the case of ob-r ...200919000220
a role for atp-sensitive potassium channels in male sexual behavior.atp-sensitive potassium (k(+)(atp)) channels regulate cell excitability and are expressed in steroid-responsive brain regions involved in sexual behavior, such as the preoptic area (poa) and medial basal hypothalamus (mbh). we hypothesized that k(+)(atp) channels serve as a mechanism by which testosterone can control the electrical activity of neurons and consequently elicit male sexual responsiveness. rt-pcr analysis indicated that castration induces, while testosterone inhibits, mrna expressio ...200918950632
the brighter side of soils: quantum dots track organic nitrogen through fungi and plants.soil microorganisms mediate many nutrient transformations that are central in terrestrial cycling of carbon and nitrogen. however, uptake of organic nutrients by microorganisms is difficult to study in natural systems. we assessed quantum dots (fluorescent nanoscale semiconductors) as a new tool to observe uptake and translocation of organic nitrogen by fungi and plants. we conjugated quantum dots to the amino groups of glycine, arginine, and chitosan and incubated them with penicillium fungi (a ...200919294917
central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area.it is widely assumed that lps lowers arterial pressure during sepsis by stimulating release of tnf-alpha and other vasoactive mediators from macrophages. however, recent data from this and other laboratories have shown that lps hypotension can be prevented by inhibiting afferent impulse flow in the vagus nerve, by blocking neuronal activity in the nucleus of the solitary tract, or by blocking alpha-adrenergic receptors in the preoptic area/anterior hypothalamic area (poa). these findings suggest ...200919295473
strategies to use phytoextraction in very acidic soil contaminated by heavy metals.in microcosm experiments, the use of inorganic and organic amendments has been studied as potential agents to reduce heavy metal bioavailability in an acidic soil highly contaminated by cu, zn and ni, that has to be remediated by phytoremediation. the concentrations of heavy metals in the original soil (o-soil) produced phytotoxic effects with a strong reduction in biomass yield that hinder the utilization of this technology. to overcome phytotoxicity the use of three immobilizing agents was eva ...200919217142
gonadal steroid action and brain sex differentiation in the rat.gonadal steroids that establish sexually dimorphic characteristics of brain morphology and physiology act at a particular stage of ontogeny. testosterone secreted by the testes during late gestational and neonatal periods causes significant brain sexual dimorphism in the rat. this results in both sex-specific behaviour and endocrinology in adults. sexual differentiation may be due to neurogenesis, migration or survival. each mechanism appears to be uniquely regulated in a site-specific manner. t ...200919226349
Refresh
firstprev
...111213141516171819
nextlast
Displaying items 1601 - 1700 of 1897