| effects of hydro-alcoholic extract from arctium lappa l. (burdock) root on gonadotropins, testosterone, and sperm count and viability in male mice with nicotinamide/ streptozotocin-induced type 2 diabetes. | reproductive dysfunction is a complication of diabetes. arctium lappa (burdock) root has hypoglycemic and antioxidative properties, which are traditionally used for treatment of impotence and sterility. therefore, the aim of this study is to investigate the effects of its hydro alcoholic extract on gonadotropin, testosterone, and sperm parameters in nicotinamide/ streptozotocin-induced diabetic mice. | 2017 | 26023292 |
| observational study of arctium lappa in the treatment of acne vulgaris. | arctium lappa (lappa) is used in traditional western and chinese medicine for acne. it is mentioned in homeopathic literature for acne, but its effect has not previously been evaluated. | 2014 | 24931753 |
| mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines. | the lignan arctigenin (arg) from the herb arctium lappa l. possesses anti-cancer activity, however the mechanism of action of arg has been found to vary among tissues and types of cancer cells. the current study aims to gain insight into the arg mediated mechanism of action involved in inhibiting proliferation and inducing apoptosis in lung adenocarcinoma cells. this study also delineates the cancer cell specificity of arg by comparison with its effects on various normal cell lines. arg selectiv ... | 2013 | 24021157 |
| four new neolignan glucosides from the fruits of arctium lappa. | four new neolignan glucosides named (7s, 8r)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-o-4'-neolignan-9'-o-β-d-apiofuranosyl-(1 → 6)-o-β-d-glucopyranoside (1), (8r)-4,9,9'-trihydroxy-3,3'-dimethoxy-7-oxo-8-o-4'-neolignan-4-o-β-d-glucopyranoside (2), (7r, 8s)-dihydrodehydrodiconiferyl alcohol-7'-oxo-4-o-β-d-glucopyranoside (3), and (7's, 8'r, 8s)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-o-β-d-glucopyranoside (4) were isolated from the fruits of arctium lappa l. their structures and ... | 2015 | 25978776 |
| hepatoprotective effect of arctium lappa root extract on cadmium toxicity in adult wistar rats. | this study was performed to determine the effects of arctium lappa (al) to protect against cadmium damage in the rat liver. male rats received a single i.p. dose of cdcl2 (1.2 mg/kg body weight (bw)) with or without al extract administered daily by gavage (300 mg/kg bw) for 7 or 56 days. after 7 days, al caused plasma transaminase activity to diminish in groups al (glutamic oxaloacetic transaminase (got) and glutamic pyruvic transaminase (gpt)) and cdal (gpt). after 56 days, got and gpt plasma a ... | 2014 | 24929543 |
| arctigenin promotes apoptosis in ovarian cancer cells via the inos/no/stat3/survivin signalling. | arctigenin is a biologically active lignan extracted from the seeds of arctium lappa and shows anticancer activity against a variety of human cancers. the aim of this study was to determine the effects of arctigenin on ovarian cancer cell proliferation and survival and associated molecular mechanisms. human ovarian cancer ovcar3 and skov3 cells were treated with arctigenin, and cell proliferation and apoptosis were assessed. western blot analysis was used to examine signal transducer and activat ... | 2014 | 24842412 |
| in vitro and in vivo antimutagenic effects of dig, a herbal preparation of berberis vulgaris, taraxacum officinale and arctium lappa, against mitomycin c. | dig, a liquid herbal preparation made from a mixture of diluted mother tinctures of berberis vulgaris, taraxacum officinale and arctium lappa, was assessed for its antimutagenic properties against mitomycin c. the micronucleus assay on chinese hamster ovary (cho)-k1 cells was used to evaluate the in vitro anticlastogenic activity of dig compared to those of separately diluted mother tinctures. the micronucleus assay was performed on mouse erythrocytes and the comet assay was performed on mouse l ... | 2015 | 25666712 |
| identification of a dicaffeoylquinic acid isomer from arctium lappa with a potent anti-ulcer activity. | leaves of arctium lappa contain several mono- and dicaffeoylquinic acids, as evaluated by liquid chromatography-mass spectrometry. in order to investigate the protection on gastric mucosa against ulcers, rats were treated with fractions from leaf extract prior to ethanol-induced ulcers. the original fraction obtained as ethanol soluble fraction from hot aqueous extract was able to protect de gastric mucosa, and this effect was retained in the ethyl acetate fraction, obtained from liquid/liquid f ... | 2015 | 25640125 |
| arctigenin protects against lipopolysaccharide-induced pulmonary oxidative stress and inflammation in a mouse model via suppression of mapk, ho-1, and inos signaling. | arctigenin, a bioactive component of arctium lappa (nubang), has anti-inflammatory activity. here, we investigated the effects of arctigenin on lipopolysaccharide (lps)-induced acute lung injury. mice were divided into four groups: control, lps, lps + dmso, and lps + arctigenin. mice in the lps + arctigenin group were injected intraperitoneally with 50 mg/kg of arctigenin 1 h before an intratracheal administration of lps (5 mg/kg). lung tissues and bronchoalveolar lavage fluids (balfs) were coll ... | 2015 | 25616905 |
| metabolite profiling of the response of burdock roots to copper stress. | arctium lappa l. (asteraceae), also known as burdock, has a long history of cultivation as a dietary vegetable worldwide. stress in plants disrupts metabolic homeostasis and requires adjustment of metabolic pathways. exposure to heavy metals is one of the most prevalent environmental stresses encountered by plants. in this study, metabolite profiling based on (1)h nmr and gc-ms was used to obtain a holistic view of the response of burdock roots to copper stress. the principal component analysis ... | 2015 | 25578619 |
| chemical analysis of raw and processed fructus arctii by high-performance liquid chromatography/diode array detection-electrospray ionization-mass spectrometry. | in traditional chinese medicine (tcm), raw and processed herbs are used to treat the different diseases. fructus arctii, the dried fruits of arctium lappa l. (compositae), is widely used in the tcm. stir-frying is the most common processing method, which might modify the chemical compositions in fructus arctii. | 2014 | 25422559 |
| behavioral and electroantennogram responses of plum curculio, conotrachelus nenuphar, to selected noxious plant extracts and insecticides. | behavioral and electroantennogram responses of plum curculio, conotrachelus nenuphar (herbst) (coleoptera: curculionidae), adults were tested for several methanolic plant extracts and organically approved insecticides. plant extracts were evaluated for their potential as antifeedants or oviposition deterrents. these extract responses were also compared to those elicited by the non-neurotoxic, organic irritant-insecticide kaolin clay. both sexes of plum curculio exhibited antennal response as mea ... | 2014 | 25368046 |
| protective effects of arctium lappa l. roots against hydrogen peroxide-induced cell injury and potential mechanisms in sh-sy5y cells. | accumulated evidence has shown that excessive reactive oxygen species (ros) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. this study was designed to explore neuroprotective effects of ethyl acetate extract of arctium lappa l. roots (eal) on hydrogen peroxide (h2o2)-induced cell injury in human sh-sy5y neuroblastoma cells. the cell viability was significantly decreased after exposure to 200 μm h2o2, whereas pretreatment with different concen ... | 2015 | 25352420 |
| effects of arctium lappa l. (burdock) root tea on inflammatory status and oxidative stress in patients with knee osteoarthritis. | this study was designed to examine the effect of burdock root tea on inflammatory markers and oxidative stress indicators in patients with knee osteoarthritis (oa). | 2016 | 25350500 |
| evaluation of hypoglycemic activity of total lignans from fructus arctii in the spontaneously diabetic goto-kakizaki rats. | fructus arctii, called "niubangzi" in china (great burdock achene in english), is a well-known chinese materia medica. it is the dried ripe fruit of arctium lappa l. (family asteraceae) and was included in the chinese pharmacopoeia for its traditional therapeutic actions. meanwhile it has been utilized extensively in a number of classical drug formulas as a major component for the treatment of noninsulin-dependent diabetes mellitus. it has also been reported recently that the clinical use of fru ... | 2014 | 24269245 |
| arctigenin but not arctiin acts as the major effective constituent of arctium lappa l. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice. | the crude powder of the fruit of arctium lappa l. (alf) has previously been reported to attenuate experimental colitis in mice. but, its main effective ingredient and underlying mechanisms remain to be identified. in this study, alf was extracted with ethanol, and then successively fractionated into petroleum ether, ethyl acetate, n-butanol and water fraction. experimental colitis was induced by dextran sulfate sodium (dss) in mice. among the four fractions of alf, the ethyl acetate fraction sho ... | 2014 | 25284342 |
| increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. | the low bioavailability of most flavonoids limits their application as anti-carcinogenic agents in humans. a novel approach of treatment with a mixture of bioactive compounds that share molecular anti-carcinogenic targets may enhance the effect on these targets at low concentrations of individual compound, thereby overcoming the limitations of reduced bioavailability. we therefore investigated whether a combination of three natural products arctigenin (arc), a novel anti-inflammatory lignan from ... | 2014 | 25243063 |
| study on human intestinal bacterium blautia sp. auh-jld56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin. | arctium lappa l. (a. lappa) is a popularly used vegetable as well as herbal medicine. human intestinal microflora was reported to convert arctiin, the lignan compound with highest content in the dried fruits of arctium lappa, to a series of metabolites. however, the specific bacterium responsible for the formation of 3'-desmethylarctigenin (3'-dmag), the most predominant metabolite of arctiin by rat or human intestinal microflora, has not been isolated yet. in the present study, we isolated one ... | 2013 | 24236649 |
| lappaol f, a novel anticancer agent isolated from plant arctium lappa l. | in an effort to search for new cancer-fighting therapeutics, we identified a novel anticancer constituent, lappaol f, from plant arctium lappa l. lappaol f suppressed cancer cell growth in a time- and dose-dependent manner in human cancer cell lines of various tissue types. we found that lappaol f induced g(1) and g(2) cell-cycle arrest, which was associated with strong induction of p21 and p27 and reduction of cyclin b1 and cyclin-dependent kinase 1 (cdk1). depletion of p21 via genetic knockout ... | 2014 | 24222662 |
| effect of arctium lappa (burdock) extract on canine dermal fibroblasts. | although the biological activities of arctium lappa (burdock) have been already investigated in human and other species, data evaluating the molecular mechanisms have not been reported in the dog. in this study we analyzed for the first time the effect of a root extract of burdock on molecular responses in canine dermal fibroblasts with h2o2 stimulation (h group), with burdock treatment (b group) and with h2o2 stimulation and burdock treatment (bh group), using rnaseq technology. differentially ... | 2013 | 24192279 |
| arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ros/p38 mapk pathway and epigenetic regulation. | this study investigates the anticancer effect of arctigenin (atg), a natural lignan product of arctium lappa l., in human breast cancer mda-mb-231 cells. results indicate that atg inhibits mda-mb-231 cell growth by inducing apoptosis in vitro and in vivo. atg triggers the mitochondrial caspase-independent pathways, as indicated by changes in bax/bcl-2 ratio, resulting in aif and endog nuclear translocation. atg increased cellular reactive oxygen species (ros) production by increasing p22(phox)/n ... | 2014 | 24140706 |
| plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by hplc-uv and lc-ms. | the pharmacokinetic profile of arctiin, the major active lignan in fruits of arctium lappa l., was investigated. its main meta"bolite arctigenin was identified by an lc-ms method, and an hplc-uv technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. chromatographic separation was performed on an agilent™ c₁₈ hplc column with acetonitrile and water by linear gradient elution. arctiin and arctigenin were identified on-line by lc-ms. the phar ... | 2012 | 22499560 |
| arctigenin promotes cholesterol efflux from thp-1 macrophages through ppar-γ/lxr-α signaling pathway. | cholesterol efflux from macrophages is a critical mechanism to prevent the development of atherosclerosis. here, we sought to investigate the effects of arctigenin, a bioactive component of arctium lappa, on the cholesterol efflux in oxidized low-density lipoprotein (oxldl)-loaded thp-1 macrophages. our data showed that arctigenin significantly accelerated apolipoprotein a-i- and high-density lipoprotein-induced cholesterol efflux in both dose- and time-dependent manners. moreover, arctigenin tr ... | 2013 | 24140409 |
| arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium. | arctigenin, a lignan extract from arctium lappa (l.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. however, the effects of arctigenin on bronchus relaxation are not well investigated. this study aimed to investigate how arctigenin regulates bronchus tone and calcium ion (ca(2+)) flow. trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, kcl, and cacl2, respectively. furthermore, l-type calcium channel cur ... | 2013 | 24114345 |
| preparation of inulin-type fructooligosaccharides using fast protein liquid chromatography coupled with refractive index detection. | a fast protein liquid chromatography coupled with refractive index detection (fplc-rid) method was firstly developed for preparation and purification of fructooligosaccharides with different degree of polymerization from burdock, arctium lappa. after extraction with 60% ethanol and decolorization with mci gel chp20p, total fructooligosaccharides were purified on bio-gel p-2 column eluted with water at the flow rate of 0.3 ml/min, which was the optimized conditions. the obtained fructooligosaccha ... | 2013 | 23962565 |
| arctigenin effectively ameliorates memory impairment in alzheimer's disease model mice targeting both β-amyloid production and clearance. | alzheimer's disease (ad) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. the β-amyloid (aβ)-induced neurodegeneration is believed to be the main pathological mechanism of ad, and aβ production inhibition or its clearance promotion is one of the promising therapeutic strategies for anti-ad research. here, we report that the natural product arctigenin from arctium lappa (l.) can both inhibit aβ prod ... | 2013 | 23926267 |
| burdock fructooligosaccharide induces stomatal closure in pisum sativum. | burdock fructooligosaccharide (bfo) isolated from the root tissue of arctium lappa is a reserve carbohydrate that can induce resistance against a number of plant diseases. stomatal closure is a part of plant innate immune response to restrict bacterial invasion. in this study, the effects of bfo on stomata movement in pisum sativum and the possible mechanisms were studied with abscisic acid (aba) as a positive control. the results showed that bfo could induce stomatal closure accompanied by ros ... | 2013 | 23911508 |
| update on phase i studies in advanced pancreatic adenocarcinoma. hunting in darkness? | over the last twenty years, there is a limited number of effective cytotoxic or biological agents that managed to get approval in advanced pancreatic ductal adenocarcinoma. despite numerous trials, investments in translational research and generally in health care, the survival of pancreatic cancer patients has improved by a few only months. this disappointing reality necessitates a better understanding of the pathogenesis of this disease and the identification of targetable alterations which mi ... | 2013 | 23846926 |
| in vitro and in vivo antioxidant activity of a fructan from the roots of arctium lappa l. | to explore new antioxidant resource from food, a water-soluble polysaccharide (alp1) was extracted and purified from the roots of arctium lappa l. (a. lappa l.) through hot water extraction followed by ethanol precipitation, ion-exchange chromatography and gel filtration. the antioxidant activity of alp1 was then evaluated in vitro and in vivo. alp1 was characterized as a fructan composed of fructose and glucose in the ratio of 13.0:1.0, with an average molecular weight of 4600 da. the linkages ... | 2014 | 24508920 |
| arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent nfatc1 pathways. | arctigenin, a lignan-derived compound, is a constituent of the seeds of arctium lappa. arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. here, we showed that arctigenin inhibited the action of nuclear factor of activated t-cells, cytoplasmic 1 (nfatc1), a key transcription factor for osteoclastogenesis. nfatc1 in osteoclast precursors was activated through two distinct pathways: the calcineurin-dependent and osteoblastic c ... | 2014 | 24465763 |
| inhibitory effect of arctigenin from fructus arctii extract on melanin synthesis via repression of tyrosinase expression. | to identify the active compound arctigenin in fructus arctii (dried seed of medicinal plant arctium lappa) and to elucidate the inhibitory mechanism in melanogenesis, we analyzed melanin content and tyrosinase activity on b16bl6 murine melanoma and melan-a cell cultures. water extracts of fructus arctii were shown to inhibit tyrosinase activity in vitro and melanin content in α -melanocyte stimulating hormone-stimulated cells to similar levels as the well-known kojic acid and arbutin, respective ... | 2013 | 23781272 |
| determination of fructooligosaccharides in burdock using hplc and microwave-assisted extraction. | the root of burdock ( arctium lappa l.) is a commonly used vegetable in asia. fructooligosaccharides (fos) are usually considered as its main bioactive components. thus, quantitative analysis of these components is very important for the quality control of burdock. in this study, an hplc-elsd and microwave-assisted extraction method was developed for the simultaneous determination of seven fos with degrees of polymerization (dp) between 3 and 9, as well as fructose, glucose, and sucrose in burdo ... | 2013 | 23745967 |
| anti-austeric activity of phenolic constituents of seeds of arctium lappa. | from seeds of arctium lappa l. (asteraceae) we obtained arctigenin (1), arctiin (2), chlorogenic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5), 3,4-dicaffeoylquinic acid (6), matairesinol (11), isolappaol a (12), lappaol f (14), and lappaol b (15), together with 1:1 mixtures of isolappaol c (7) and lappaol c (8), arctignan e (9) and arctignan d (10), and 12 and lappaol a (13), while 3,3',4'-tri-o-demethylarctigenin (16), 3,3'-di-o-demethyl-4'-dehydroxyarctigenin (17), an ... | 2013 | 23738454 |
| hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by lc/ms/ms after oral administration in rats. | the phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. using lc/ms/ms, three novel metabolites of arctigenin, namely, arctigenic acid, arctigenin-4-o'-glucuronide, and 4-o-demethylarctigenin were identified after oral administration of arctigenin in rats for the first time. another potential metabolite of arctigenin, arc ... | 2013 | 23519790 |
| arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the pi3k/akt pathway and polarizing m1 macrophages to m2-like macrophages. | seeds of arctium lappa, containing arctigenin and its glycoside arctiin as main constituents, have been used as a diuretic, anti-inflammatory and detoxifying agent in chinese traditional medicine. in our preliminary study, arctigenin inhibited ikkβ and nf-κb activation in peptidoglycan (pgn)- or lipopolysaccharide (lps)-induced peritoneal macrophages. to understand the anti-inflammatory effect of arctigenin, we investigated its anti-inflammatory effect in lps-stimulated peritoneal macrophages an ... | 2013 | 23375938 |
| anti-inflammatory intestinal activity of arctium lappa l. (asteraceae) in tnbs colitis model. | in brazilian traditional medicine, arctium lappa (asteraceae), has been reported to relieve gastrointestinal symptoms. | 2013 | 23313393 |
| arctiin induces an uvb protective effect in human dermal fibroblast cells through microrna expression changes. | ultraviolet (uv) radiation induces severe alterations in the molecular and cellular components of normal human dermal fibroblast (nhdf) cells by disrupting many intracellular transduction cascades. although uv responses have been well documented at the genome and proteome levels, uv protective effects have not been elucidated at these levels. the aim of the present study was to demonstrate that arctiin, a phytochemical isolated from the plant arctium lappa, induced a protective effect against uv ... | 2014 | 24398562 |
| the efficacy and safety of a proposed herbal moisturising cream for dry skin and itch relief: a randomised, double-blind, placebo-controlled trial--study protocol. | moisturisers prevent and treat dry skin. they can also protect sensitive skin, improve skin tone and texture, and mask imperfections. herbal medicines or their extracts have been available as topical formulations and cosmetics. arctium lappa l. (asteraceae) has been used to treat inflammatory disorders and various skin problems. it could be a candidate herbal medicine for treating dry skin condition.this study aims to establish the efficacy and safety of a proposed herbal moisturising cream cont ... | 2013 | 24274317 |
| ethanolic extract of roots from arctium lappa l. accelerates the healing of acetic acid-induced gastric ulcer in rats: involvement of the antioxidant system. | we evaluate the curative efficacy of the ethanolic extract (eet) of roots from arctium lappa (bardana) in healing of chronic gastric ulcers induced by 80% acetic acid in rats and additionally studies the possible mechanisms underlying this action. oral administration of eet (1, 3, 10 and 30mg/kg) reduced the gastric lesion area in 29.2%, 41.4%, 59.3% and 38.5%, respectively, and at 10mg/kg promoted significant regeneration of the gastric mucosa, which was confirmed by proliferating cell nuclear ... | 2013 | 23036453 |
| body weight management effect of burdock (arctium lappa l.) root is associated with the activation of amp-activated protein kinase in human hepg2 cells. | burdock (arcticum lappa l.) root is used in folk medicine and also as a vegetable in asian countries. in the present study, burdock root treatment significantly reduced body weight in rats. to evaluate the bioactive compounds, we successively extracted the burdock root with ethanol (al-1), and fractionated it with n-hexane (al-2), ethyl acetate (al-3), n-butanol (al-4), and water (al-5). among these fractions, al-2 contained components with the most effective hypolipidemic potential in human hep ... | 2012 | 25005949 |
| arctium lappa ameliorates endothelial dysfunction in rats fed with high fat/cholesterol diets. | arctium lappa l. (asteraceae), burdock, is a medicinal plant that is popularly used for treating hypertension, gout, hepatitis, and other inflammatory disorders. this study was performed to test the effect of ethanol extract of arctium lappa l. (eal) seeds on vascular reactivity and inflammatory factors in rats fed a high fat/cholesterol diet (hfcd). | 2012 | 22866890 |
| effects of arctiin on streptozotocin-induced diabetic retinopathy in sprague-dawley rats. | diabetic retinopathy is one of the most common and severe complications of diabetes mellitus. arctiin, a bioactive compound isolated from the dry seeds of arctium lappa l., has been reported to have antidiabetic activity. in this study, we investigated the effect of arctiin on the serum glucose and hba1c levels, the blood viscosity, and vegf expression in the retinal tissues of rats with diabetic retinopathy. we first extracted arctiin from fructus arctii and then investigated its chemopreventiv ... | 2012 | 22753037 |
| arctigenin alleviates er stress via activating ampk. | to investigate the protective effects of arctigenin (atg), a phenylpropanoid dibenzylbutyrolactone lignan from arctium lappa l (compositae), against er stress in vitro and the underlying mechanisms. | 2012 | 22705729 |
| cytotoxic effect of some medicinal plants from asteraceae family on j-45.01 leukemic cell line--pilot study. | in this study the in vitro cytotoxic properties of ethanol extracts from the herbs, inflorescents and roots of selected asteraceae species: arctium lappa, artemisia absinthium, calendula officinalis, centaurea cyanus, tanacetum vulgare and tragopogon pratensis on j-45.01 human acute t leukemia cell line was examined. all tested samples possess antileukemic properties and induce cells death via apoptosis. the correlation between antileukemic activity and total polyphenol content was determined. | 2012 | 22568040 |
| comparative analysis of caffeoylquinic acids and lignans in roots and seeds among various burdock (arctium lappa) genotypes with high antioxidant activity. | caffeoylquinic acids and lignans in the crude extracts of both roots and seeds from different burdock ( arctium lappa l.) genotypes were simultaneously characterized and systematically compared by lc-ms and matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight mass spectrometry (maldi-qit-tof ms), and their antioxidant activities were also investigated. a total of 14 lignans were identified in burdock seeds and 12 caffeoylquinic acids in burdock roots. high levels of caf ... | 2012 | 22497441 |
| lapacho tea (tabebuia impetiginosa) extract inhibits pancreatic lipase and delays postprandial triglyceride increase in rats. | earlier work in our laboratory indicated that ethanolic extracts of tabebuia impetiginosa, arctium lappa l., calendula officinalis, helianthus annuus, linum usitatissimum and l. propolis, inhibit pancreatic lipase in vitro. in a follow-up study we assessed their effects on plasma triglycerides in rats fed on a fatty meal. extracts, orlistat or only ethanol were given orally to the rats together with the test meal and the rate of increase of postprandial triglycerides was assessed over 4 h. clear ... | 2012 | 22431070 |
| optimum yields of dibenzylbutyrolactone-type lignans from cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods. | dibenzylbutyrolactone-type lignans are the physiologically active constituents of the achene fruits of cynareae. these lignans occur in glycoside/aglycone forms: in the highest quantity of the arctiin/arctigenin, matairesinoside/matairesinol and tracheloside/trachelogenin pairs found in the fruits of arctium lappa l., centaurea scabiosa l. and cirsium arvense (l.) scop. | 2013 | 22396124 |
| new expectations from the well-known medicinal properties of arctium lappa. | amp-activated protein kinase (ampk) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. indeed, ampk has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. in this issue of diabetologia (doi: 10.1007/s00125-011-2366-3 ), huang and co-workers report that arctigenin activates muscle uptake of glucose and inhibits hepatocyte gluconeogenesis and lipogenesis by reducing mitochondrial respir ... | 2012 | 22358500 |
| tumor specific cytotoxicity of arctigenin isolated from herbal plant arctium lappa l. | the effectiveness of cancer chemotherapy is often limited by the toxicity to other tissues in the body. therefore, the identification of non-toxic chemotherapeutics from herbal medicines remains to be an attractive goal to advance cancer treatments. this study evaluated the cytotoxicity profiles of 364 herbal plant extracts, using various cancer and normal cell lines. the screening found occurrence of a549 (human lung adenocarcinoma) specific cytotoxicity in nine species of herbal plants, especi ... | 2012 | 22350142 |
| evaluation of the antiproliferative activity of the leaves from arctium lappa by a bioassay-guided fractionation. | arctium lappa l. (asteraceae) is used in folk medicine around the world, and shows several kinds of biological activity, particularly in vitro antitumor activity in different cell lines. this study evaluated the antiproliferative activity of the crude extract, semipurified fractions, and isolated compounds from the leaves of a. lappa, through bioassay-guided testing in caco-2 cells. the crude extract was obtained with a 50% hydroethanolic extract and then partitioned with hexane, ethyl acetate, ... | 2012 | 22334063 |
| moisture sorption isotherms and glass transition temperature of elecampe (inula helenium l.) and burdock (arctium lappa l.) roots at 25°c. | sorption isotherms of elecampe (inula helenium l.) and burdock (arctium lappa l.) root samples were obtained at 25 °c. elecampe exhibited hysteresis loop in the range of 0.35-0.90 a(w) , whereas burdock roots showed significant differences between adsorption and desorption isotherms from 0.65 to 0.80 a(w) . blahovec-yanniotis was considered to give the best fit over the whole range of a(w) tested. various parameters describing the properties of sorbed water derived from gab, henderson and blahov ... | 2012 | 22328123 |
| essiac tea: scavenging of reactive oxygen species and effects on dna damage. | essiac, a tea reportedly developed by the ojibwa tribe of canada and widely publicized as a homeopathic cancer treatment, is prepared from a mixture of four herbs arctium lappa, rumex acetosella, ulmus rubra and rheum officinale. each of these herbs has been reported to possess antioxidant and anti-cancer activity. essiac itself has also been reported to demonstrate anti-cancer activity in vitro, although its effects in vivo are still a matter of debate. we prepared an extract of essiac tea from ... | 2006 | 16226859 |
| effect of aqueous extract of arctium lappa l. (burdock) roots on the sexual behavior of male rats. | arctium lappa l. root has traditionally been recommended as an aphrodisiac agent. it is used to treat impotence and sterility in china, and native americans included the root in herbal preparations for women in labor. however, its use has not been scientifically validated. the present study therefore investigated the effects of aqueous extract of arctium lappa l. roots on sexual behavior in normal male rats. | 2012 | 22296876 |
| anti-ulcerogenic mechanisms of the sesquiterpene lactone onopordopicrin-enriched fraction from arctium lappa l. (asteraceae): role of somatostatin, gastrin, and endogenous sulfhydryls and nitric oxide. | arctium lappa l. has been used in folk medicine as a diuretic, depurative, and digestive stimulant and in dermatological conditions. the mechanisms involved in the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (onp)-enriched fraction (termed the onp fraction), obtained from a. lappa leaves, were studied. the gastroprotective mechanism of the onp fraction was evaluated in experimental in vivo models in rodents, mimicking this disease in humans. onp fraction (50 mg/kg, p.o.) signif ... | 2012 | 22191571 |
| [study on correlation between its sequence of arctium lappa and quality of fructus arctii]. | to study the correlation between its sequence of arctium lappa and fructus arctii quality of different origin. | 2011 | 22016962 |
| triterpenoids from arctium lappa. | phytochemical investigation of the leaves of arctium lappa led to the isolation of two triterpenoids, characterised by nmr, ir and ms as 3α-hydroxylanosta-5,15-diene and 3α-acetoxy-hop-22(29)-ene. 3α-hydroxylanosta-5,15-diene is a new triterpenoid and is isolated for the first time from this genus. | 2012 | 21848484 |
| identification and characterization of five new classes of chlorogenic acids in burdock (arctium lappa l.) roots by liquid chromatography/tandem mass spectrometry. | burdock (arcticum lappa l.) roots are used in folk medicine and also as a vegetable in asian countries especially japan, korea, and thailand. we have used lc-ms(n) (n = 2-4) to detect and characterize in burdock roots 15 quantitatively minor fumaric, succinic, and malic acid-containing chlorogenic acids, 11 of them not previously reported in nature. these comprise 3-succinoyl-4,5-dicaffeoyl or 1-succinoyl-3,4-dicaffeoylquinic acid, 1,5-dicaffeoyl-3-succinoylquinic acid, 1,5-dicaffeoyl-4-succinoy ... | 2011 | 21773587 |
| arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the stat3 signaling pathway. | arctigenin is a dibenzylbutyrolactone lignan isolated from bardanae fructus, arctium lappa l, saussureamedusa, torreya nucifera, and ipomea cairica. it has been reported to exhibit anti-inflammatory activities, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappab (nf-κb). but the role of arctigenin in jak-stat3 signaling pathways is still unclear. in present study, we investigated the effect of arctigenin on signal transducer and activator of transcriptio ... | 2011 | 21608020 |
| uplc and hplc of caffeoyl esters in wild and cultivated arctium lappa l. | analytical methods including ultra-performance liquid chromatography (uplc) and high-performance liquid chromatography (hplc) with photodiode array (pda) detector were developed for the analysis of caffeoylquinic acid derivatives in seeds, leaves and roots of arctium lappa l. separation was performed on c(18) column utilising 5% (v/v) acetic acid in water and acetonitrile at 330 nm. both methodologies were validated in terms of linearity, precision, and recovery. the results showed that the majo ... | 2013 | 23265494 |
| effect of arctiin on glomerular filtration barrier damage in stz-induced diabetic nephropathy rats. | diabetic nephropathy (dn) is the major life-threatening complication of diabetes. abnormal permeability of glomerular basement membrane plays an important role in dn pathogenesis. this study was performed to assess the effect of arctiin, the lignan constituent from arctium lappa l., on metabolic profile and aggravation of renal lesions in a rat model of streptozotocin (stz)-induced dn. stz-induced diabetic rats were treated with arctiin at the dosage of 60 or 40 mg/kg/day via intraperitoneal inj ... | 2013 | 23147865 |
| isolation and characterization of a xyloglucan from gobo (arctium lappa l.). | a xyloglucan was isolated from the 24% koh extract of gobo (edible burdock, arctium lappa l.). a methylation analysis and enzymic degradation studies on the polysaccharide showed that gobo-xyloglucan was built up predominantly of repeating-oligosaccharide units of hepta-(glc:xyl = 4:3), nona- (glc:xyl:gal:fuc = 4:3:1:1) and deca- (glc:xyl:gal:fuc = 4:3:2:1) saccharides in an approximate molar ratio of 14:12:5, which are the typical structural units of dicot xyloglucans. | 1993 | 7764226 |
| purification and characterization of arctium lappa l. (edible burdock) polyphenol oxidase. | polyphenol oxidase of arctium lappa l. (edible burdock) has been purified by chromatographies on deae-cellulose, sephadex g-75, and phenyl-cellulofine to a homogeneous state as judged by sds polyacrylamide gel electrophoresis. the molecular weight of the purified enzyme was estimated to be 31,000 by sds-page and 25,000 by gel filtration on tskgel g2000sw. the optimum ph was 7.0 and the enzyme was stable at ph 7.0-9.0. the enzyme oxidized triphenols such as pyrogallol and phloroglucinol, and was ... | 1993 | 27314765 |
| [studies on the chemical constituents of arctium lappa l]. | six compounds were isolated from the seeds of arctium lappa l. one of them is a new lignan named neoarctin b(vi). the structure has been elucidated on the basis of spectral (uv, ir, 1h-nmr, 13c-nmr, dept, 2d-nmr and ms) analysis. the other five compounds were identified as daucosterol (i), arctigenin (ii), arctiin (iii), matairesinol (iv) and lappaol f (v). | 1993 | 8030415 |
| in vitro anti-inflammatory effects of arctigenin, a lignan from arctium lappa l., through inhibition on inos pathway. | arctigenin, a bioactive constituent from dried seeds of arctium lappa l. (compositae) which has been widely used as a traditional chinese medicine for dispelling wind and heat included in chinese pharmacophere, was found to exhibit anti-inflammatory activities but its molecular mechanism remains unknown yet. | 2009 | 19429312 |
| metabolic profile of the bioactive compounds of burdock (arctium lappa) seeds, roots and leaves. | in this work the bioactive metabolic profile, the antioxidant activity and total phenolic content of burdock (arctium lappa) seeds, leaves and roots were obtained. teac values and total phenolic content for hydro-alcoholic extracts of burdock ranged from 67.39 to 1.63 micromol trolox equivalent/100g dry weight (dw), and from 2.87 to 45 g of gallic acid equivalent/100g dw, respectively. phytochemical compounds were analyzed by liquid chromatography coupled to electrospray tandem mass spectrometry ... | 2010 | 19375261 |
| identification of hydroxycinnamoylquinic acids of arnica flowers and burdock roots using a standardized lc-dad-esi/ms profiling method. | a screening method using lc-dad-esi/ms was developed for the identification of common hydroxycinnamoylquinic acids based on direct comparison with standards. a complete standard set for mono-, di-, and tricaffeoylquinic isomers was assembled from commercially available standards, positively identified compounds in common plants (artichokes, asparagus, coffee bean, honeysuckle flowers, sweet potato, and vernonia amygdalina leaves) and chemically modified standards. four c18 reversed phase columns ... | 2008 | 18837557 |
| screening report on the antitumor activity of purified arctium lappa extracts. | | 2008 | 5962247 |
| [macroscopic differentiation of tussilago farfara l. from arctium lappa l. and petasites officinalis moench]. | | 1955 | 14391351 |
| [nutritional demands of the great thistle (arctium lappa l)]. | | 1952 | 13003515 |
| diarctigenin, a lignan constituent from arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of dna binding ability of nuclear factor-kappab in macrophages. | diarctigenin was previously isolated as an inhibitor of nitric oxide (no) production in macrophages from the seeds of arctium lappa used as an alternative medicine for the treatment of inflammatory disorders. however, little is known about the molecular basis of these effects. here, we demonstrated that diarctigenin inhibited the production of no, prostaglandin e(2), tumor necrosis factor-alpha, and interleukin (il)-1beta and il-6 with ic(50) values of 6 to 12 micirom in zymosan- or lipopolysacc ... | 2008 | 18694995 |
| arctigenin: a lignan from arctium lappa. | the title compound {systematic name: (3r-trans)-4-[(3,4-dimethoxy-phen-yl)meth-yl]-3-[(4-hydr-oxy-3-methoxy-phen-yl)meth-yl]-4,5-dihydrofuran-2(3h)-one}, c(21)h(24)o(6), has a dibenz-yl-butyrolactone skeleton. the two aromatic rings are inclined at a dihedral angle of 68.75 (7)° with respect to each other. the lactone ring adopts an envelope conformation. a series of o-h⋯o and c-h⋯o hydrogen bonds contribute to the stabilization of the crystal packing. the absolute configuration was assigned on ... | 2008 | 21203243 |
| a new lignan from the seeds of arctium lappa. | a new compound, neoarctin a (1), together with nine known compounds (2-10), were obtained from the ethanolic extract of the seeds of arctium lappa. the structure of 1 was elucidated on the basis of spectral and chemical evidence. | 2009 | 17885842 |
| [relative adscriptions of components in the effective fractions of yinqiao decoction and its composing individual herbs]. | hplc and lc-ms/ms were used to establish a comprehensive hplc analytical method of yinqiao decoction and identify the chemical constituents of the whole and individual herbs of yinqiao decoction. ywg-c18 (250 mm x4. 6 mm id, 10 microm) column was used; the mobile phase was composed of acetonitrile (a) and water ( b, with 3% acetic acid) with gradient elution; the flow rate was 1. 0 ml x min(-1) and the column temperature was set up at 25 degrees c. the detection wavelength was 280 nm. the chroma ... | 2007 | 17518050 |
| lignans from arctium lappa and their inhibition of lps-induced nitric oxide production. | a new butyrolactone sesquilignan, isolappaol c (1), together with four known lignans, lappaol c (2), lappaol d (3), lappaol f (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the arctium lappa plant. the structure of isolappaol c (1) was determined by spectral analysis including 1d- and 2d-nmr. all the isolates were evaluated for their inhibitory effects on the lps-induced nitric oxide production using murine macrophage raw264.7 cells. lappaol f (4) and diar ... | 2007 | 17202721 |
| [study on condition for extraction of arctiin from fruits of arctium lappa using supercritical fluid extraction]. | to study the feasibility of supercritical fluid extraction (sfe) for arctiin from the fruits of arctium lappa. | 2006 | 17048565 |
| antioxidant activity of medicinal plant polysaccharides. | eleven polysaccharides have been isolated from the leaves of arctium lappa var. herkules, aloe barbadensis, althaea officinalis var. robusta, plantago lanceolata var. libor, aerial parts and roots of rudbeckia fulgida var. sullivantii, stems of mahonia aquifolium, and peach-tree (prunus persica) gum exudates. the polysaccharides were investigated for their ability to inhibit peroxidation of soyabean lecithin liposomes by oh radicals. the highest inhibition was found with glucuronoxylans of a. of ... | 2006 | 16797146 |
| antiproliferative and apoptotic effects of butyrolactone lignans from arctium lappa on leukemic cells. | in the course of screening for pharmacologically active substances from extracts of crude drugs used traditionally in sino-japanese herbal medicines, it was found that the 70 % ethanol extract from the fruits of arctium lappa l. (compositae) showed potent antiproliferative activity against b cell hybridoma cell, mh60. by bioassay-guided purification, a new lignan, (+)-7,8-didehydroarctigenin, together with the known lignans (-)-arctigenin and (-)-matairesinol were isolated as the active ingredie ... | 2006 | 16534737 |
| [dyuamical studies on metabolic chemistry of lignans from seeds of arctium lappa]. | to study the metabolic chemistry and pharmaco-dynamics characters of ligan from seeds of arctium lappa. | 2005 | 16245912 |
| isolation and identification of arctiin and arctigenin in leaves of burdock (arctium lappa l.) by polyamide column chromatography in combination with hplc-esi/ms. | a simple method involving polyamide column chromatography in combination with hplc-pad and hplc-esi/ms for isolating and identifying two kinds of lignans, arctiin and arctigenin, in the leaves of burdock (arctium lappa l.) has been established. after extraction of burdock leaves with 80% methanol, the aqueous phase of crude extracts was partitioned between water and chloroform and the aqueous phase was fractionated on a polyamide glass column. the fraction, eluting with 100% methanol, was concen ... | 2012 | 15881114 |
| application of preparative high-speed counter-current chromatography for separation and purification of arctiin from fructus arctii. | following an initial clean-up step on the ab-8 resin (polystyrene resin, 0.3-1.25 mm: nankai chemical factory, tianjin, china), high-speed counter-current chromatography (hsccc) was used to purify an arctiin from an extract of the fruits of the arctium lappa l. arctiin is a major lignan compound in the traditional chinese medicinal herb a. lappa l. the two-phase solvent system used was composed of ethyl acetate-n-butanol-ethanol-water at an optimized volume ratio of 5:0.5:1:5 (v/v/v/v). the uppe ... | 2005 | 15700478 |
| arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits map kinases and ap-1 activation via potent mkk inhibition: the role in tnf-alpha inhibition. | arctigenin, naturally occurring in bardanae fructus, saussurea medusa, arctium lappa l., torreya nucifera and ipomea cairica, is a phenylpropanoid dibenzylbutyrolactone lignan with antioxidant and anti-inflammatory activities. previously, we showed that arctigenin potently inhibited the induction of nitric oxide synthase (inos) by lipopolysaccharide (lps), which involved suppression of nf-kappab activation. in the present study, we examined the effects of arctigenin on mitogen-activated protein ... | 2004 | 15313439 |
| stereochemical diversity in lignan biosynthesis of arctium lappa l. | the stereochemistry of lignan biosynthesis in arctium lappa l. is regulated organ-specifically. (+)-secoisolariciresinol [81% enantiomeric excess (e.e.)] was isolated from a. lappa petioles. in sharp contrast, lignans whose predominant enantiomers have the opposite absolute configuration to that of (+)-secoisolariciresinol [i.e., (-)-matairesinol (>99% e.e.), (-)-arctigenin (>99% e.e.), and (-)-secoisolariciresinol (65% e.e.)] were isolated from seeds of the species. the stereochemical diversity ... | 2002 | 12162547 |
| [metabolism in arctium lappa l. at the primary stage of germination]. | to investigate the metabolic changes of the seeds at the primary stage of germination in arctium lappa. | 1998 | 11599357 |
| hepatoprotective effects of arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. | the root of arctium lappa linne (a. lappa) (compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. in order to investigate the hepatoprotective effects of a. lappa, male icr mice were injected with carbon tetrachloride (ccl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.). a. lappa suppressed the sgot and sgpt elevations induced by ccl4 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological ob ... | 2000 | 10999435 |
| stereochemical difference in secoisolariciresinol formation between cell-free extracts from petioles and from ripening seeds of arctium lappa l. | cell-free extracts from ripening seeds of arctium lappa l. catalyzed the enantioselective formation of (-)-pinoresinol, (-)-lariciresinol and (-)-secoisolariciresinol from achiral coniferyl alcohol in the presence of nadph and h2o2. the enantioselectivity of the lignan formation was opposite to that of the (+)-secoisolariciresinol formation catalyzed by cell-free extracts from petioles of the same plant species. | 1998 | 27397009 |
| cloning and functional characterization of a fructan 1-exohydrolase (1-feh) in edible burdock (arctium lappa l.). | we have previously reported on the variation of total fructooligosaccharides (fos), total inulooligosaccharides (ios) and inulin in the roots of burdock stored at different temperatures. during storage at 0°c, an increase of fos as a result of the hydrolysis of inulin was observed. moreover, we suggested that an increase of ios would likely be due to the synthesis of the ios by fructosyltransfer from 1-kestose to accumulated fructose and elongated fructose oligomers which can act as acceptors fo ... | 2011 | 21463533 |
| a review of the pharmacological effects of arctium lappa (burdock). | arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy and nutritive food in chinese societies. burdock has been used therapeutically in europe, north america and asia for hundreds of years. the roots, seeds and leaves of burdock have been investigated in view of its popular uses in traditional chinese medicine (tcm). in this review, the reported therapeutic effects of the active compounds present in the different botanical parts of burdock are summarized. in the ro ... | 2011 | 20981575 |
| allergic contact dermatitis due to burdock (arctium lappa). | | 1995 | 8549139 |
| determination of the major constituents in fruit of arctium lappa l. by matrix solid-phase dispersion extraction coupled with hplc separation and fluorescence detection. | the arctiin and arctigenin in the fruit of arctium lappa l. were extracted by matrix solid-phase dispersion (mspd) and determined by high-performance liquid chromatography (hplc) with fluorescence detection. the experimental conditions for the mspd were optimized. silica gel was selected as dispersion adsorbent and methanol as elution solvent. the calibration curve showed good relationship (r>0.9998) in the concentration range of 0.010-5.0μgml(-1) for arctiin and 0.025-7.5μgml(-1) for arctigenin ... | 2010 | 20810325 |
| on-line coupling of counter-current chromatography and macroporous resin chromatography for continuous isolation of arctiin from the fruit of arctium lappa l. | in this work, we have developed a novel hybrid two-dimensional counter-current chromatography and liquid chromatography (2d ccc x lc) system for the continuous purification of arctiin from crude extract of arctium lappa. the first dimensional ccc column has been designed to fractionalize crude complex extract into pure arctiin effluent using a one-component organic/salt-containing system, and the second dimensional lc column has been packed with macroporous resin for on-line adsorption, desalina ... | 2010 | 20619844 |
| determination of arctiin and arctigenin in fructus arctii by reverse-phase hplc. | the fruits of arctium lappa l. is an often-used herbal drug in traditional chinese medicine for the treatment of common cold caused by wind and heat. this drug contained many constituents, principally arctiin, with arctigenin in smaller amount. in this work, arctiin has been isolated from the fruits of arctium lappa, and then enzymolyzed into arctigenin. the obtained arctiin and arctigenin were characterized and then used as standards for their determination in the crude drug by hplc. the method ... | 1992 | 1442089 |
| [on the constituents of the fruit of arctium lappa (author's transl)]. | | 1976 | 1035634 |
| beneficial effect of dietary fiber on the upper gastrointestinal transit time in rats suffering from a toxic dose of amaranth. | gobo dietary fiber (gdf) obtained from the roots of edible burdock (arctium lappa l.) was examined for its protective role against amaranth (food red no. 2, am) toxicity in the upper gastrointestinal tract (from the mouth to the ileal end) of rats. ileorectostomized rats were examined for their growth response to feeding with a purified basal diet containing 4% am with or without 7.5% gdf. the transit half-time (tt50) through the upper gastrointestinal tract was also examined with ileostomized r ... | 1992 | 27280645 |