Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the effect of hypophysectomy on 9,10-dimethyl-1,2-benzanthracene-induced carcinogenesis [abstract]. | in view of the findings of moon, simpson, and evans (science, 116:331,1952) that the hypophysectomized rat was refractory to the carcinogenic effect of methyl-cholanthrene, similar experiments have been conducted but using the more powerful carcinogen 9,10-dimethyl-1,2-benzanthracene. the results of 2 separate experiments were as follows: all animals received 5 mg in sesame oil of the carcinogen intramuscularly. in the control animals, 15 showed discrete sarcoma out of 21 animals in 4-5 month ... | 1954 | 12338146 |
| repeated anabolic-androgenic steroid treatment during adolescence increases vasopressin v(1a) receptor binding in syrian hamsters: correlation with offensive aggression. | repeated anabolic-androgenic steroid treatment during adolescence increases hypothalamic vasopressin and facilitates offensive aggression in male syrian hamsters (mesocricetus auratus). the current study investigated whether anabolic-androgenic steroid exposure during this developmental period influenced vasopressin v(1a) receptor binding activity in the hypothalamus and several other brain areas implicated in aggressive behavior in hamsters. to test this, adolescent male hamsters were administe ... | 2002 | 12367571 |
| healing action of nerve growth factor on lameness in adult goats. | we investigated the effect of nerve growth factor in goats affected by lameness, a condition that is associated with cutaneous ulcers, abscesses and granulomas. lesions were treated daily with 1 microgram of nerve growth factor (ngf), dissolved in 100 microliters of sesame oil or with sesame oil only. healthy controls were treated with sesame oil only for periods ranging from two to four weeks and behavioral, biochemical and histopathological conditions were evaluated. topical application of ngf ... | 2002 | 12387143 |
| microbial retention characteristics of sterilizing-grade membrane filters with alginate substituted for oil-based products. | for oil-based products, fda recommends substitution of the oil with a compound which has similar viscosity and physical characteristics. in this study, a substitute for oil-based products was screened by measuring the viscosity and filterability, and examined for the presence of cell clumps in the various test fluids using an optical microscopy. the viscosity of the test fluids measured in the range of about 60-75 cp. brevundimonas diminuta (formerly pseudomonas diminuta), a standard challenge t ... | 2002 | 12404720 |
| preparation and characterization of papain-modified sesame (sesamum indicum l.) protein isolates. | defatted sesame meal ( approximately 40-50% protein content) is very important as a protein source for human consumption due to the presence of sulfur-containing amino acids, mainly methionine. sesame protein isolate (spi) is produced from dehulled, defatted sesame meal and used as a starting material to produce protein hydrolysate by papain. protein solubility at different ph values, emulsifying properties in terms of emulsion activity index (eai) and emulsion stability index (esi), foaming pro ... | 2002 | 12405787 |
| high levels of estradiol impair spatial performance in the morris water maze and increase 'depressive-like' behaviors in the female meadow vole. | the present study investigated sex differences and the effect of a high level of estradiol in the female meadow vole on performance in the forced swim test (fst) and the morris water maze in meadow voles. female meadow voles were ovariectomized (ovx) and administered either vehicle (sesame oil) or estradiol for 2 days prior to performing the fst. four days following the fst, all animals were run in the morris water maze. results indicated that estradiol-injected female meadow voles showed more ' ... | 2002 | 12419397 |
| posttraining androgens' enhancement of cognitive performance is temporally distinct from androgens' increases in affective behavior. | steroid hormone-induced variations in spatial learning and memory tasks have been reported. in this study, androgens' effects in various cognitive and affective tasks were investigated in order to determine whether any observed differences in cognitive performance could be due to affective changes produced by the hormones. ovariectomized rats (n = 72) received 0.0, 3.0, or 7.5 mg/kg subcutaneously, of testosterone (t), dihydrotestosterone (dht), or 5 alpha-androstane-3 alpha,17 beta-diol (3 alph ... | 2001 | 12467112 |
| bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. | the industrial chemical, 4-vinylcyclohexene diepoxide (vcd), kills oocytes within immature follicles in the ovaries of mice and rats and is considered a potential occupational health hazard. it has been reported that vcd-induced follicle loss occurs via a cell death process involving elevated expression of bax, a proapoptotic bcl-2 family member, and increased caspase-3-like activity. we have previously shown that oocytes lacking acid sphingomyelinase (asmase; an enzyme that generates the proapo ... | 2003 | 12488331 |
| preimplantation mouse embryo development as a target of the pesticide methoxychlor. | effects of methoxychlor (mxc) and estradiol-17beta (e) were studied in mouse preimplantation embryos. pregnant mice received s.c. injections of sesame oil only, 10 microg e, or 0.5 mg purified (95%) mxc on days 2-4 of pregnancy (plug = day 1). another group received a single dose of 2.5 microg e on day 2 only. based on the average weight of pregnant females, 10 microg of estradiol was equivalent to 0.33 mg/kg of bw, 2.5 microg of estradiol was equivalent to 0.082 mg/kg of bw, and the 0.5-mg dose ... | 2003 | 12507662 |
| bisphenol a increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats. | recently, we reported that bisphenol a (bpa), an endocrine disrupter, increased progesterone receptor (pr) mrna in the preoptic area (poa) in adult ovariectomized rats. in the present study, we examined whether bpa also induced expression of pr proteins in both the poa and the ventromedial hypothalamic nucleus (vmh), and whether those proteins were involved in the induction of sexual behaviour. two weeks after ovariectomy, rats received a subcutaneous (s.c.) injection of bpa, 17 beta-oestradiol ... | 2003 | 12535155 |
| hypothalamic indolamines during embryonic development and effects of steroid exposure. | the serotonin system has been implicated in the modulation of endocrine and behavioral components of reproduction. in this study, we examined endogenous hypothalamic indolamines during sexual differentiation and long-term effects of exogenous steroids during this time. in experiment 1, japanese quail were studied during the last half of embryonic development and early post-hatch. samples were taken at embryonic day 10 (e10), e12, e14, e16, hatch (day 0), and days 3 and 5, post-hatch. hypothalami ... | 2003 | 12535620 |
| passive transfer of nut allergy after liver transplantation. | an anaphylactic reaction to cashew nut developed in a nonatopic 60-year-old man 25 days after receiving a liver allograft from a 15-year-old atopic boy who died of anaphylaxis after peanut ingestion. the liver recipient had no history of nut allergy. posttransplantation skin prick test results were positive for peanut, cashew nut, and sesame seed, and the donor had allergen-specific ige antibodies to the same 3 allergens. contact tracing of the recipients of other solid organs from the same dono ... | 2003 | 12546616 |
| effect of excessive intake of thermally oxidized sesame oil on lipids, lipid peroxidation and antioxidants' status in rats. | fresh and thermally oxidized sesame, groundnut and coconut oils were fed to different groups of rats, as high fat diet (20%). feeding fresh and thermally oxidized oils increased the levels of total cholesterol, low density lipoprotein cholesterol (ldl-c), and phospholipids but high density lipoprotein cholesterol (hdl-c) decreased in all the experimental animals. the levels of very low density lipoproteincholesterol (vldl-c) and triacylglycerol increased only in groundnut and coconut oils-fed gr ... | 2000 | 12557909 |
| ntp studies of magnetic field promotion (dmba initiation) in female sprague-dawley rats (whole-body exposure/gavage studies). | electric and magnetic fields are associated with the production, transmission, and use of electricity; thus, the potential for human exposure is high. these elec-tric and magnetic fields are predominantly of low fre-quency (60 hz in the united states and 50 hz in europe) and generally of low intensity. because some epidemiology studies and initiation/promotion studies in rats have suggested a potential for increased breast cancer rates with increasing magnetic field exposure, the ability of 50- ... | 1999 | 12563342 |
| edible oil crops and their integration with the major cereals in north shewa and south welo, central highlands of ethiopia: an ethnobotanical perspective. | a total of 1050 sorghum (sorghum bicolor) and tef (eragrostis tef) fields distributed in six study sites within north shewa and south welo (central highlands of ethiopia) were systematically surveyed to examine the status of integration of edible oil crops into the cereal-based farming system. farmers' criteria for, and perception on, integration between edible oil crops and the major cereals at field level as well as integration between the cereal grains and the oilseeds in food making at home ... | 2002 | 12564630 |
| overload-induced androgen receptor expression in the aged rat hindlimb receiving nandrolone decanoate. | this study's purpose was to examine whether functional overload with nandrolone decanoate (nd) administration increased muscle mass and steroid receptor concentration in aged rat soleus (sol) and plantaris (plan) muscle. nd (6 mg/kg body wt) was administered once a week for 4 wk, whereas control rats received sesame seed oil injections. functional overload of the hindlimb sol and plan was induced by synergistic gastrocnemius muscle ablation at the beginning of the fourth week. adult (5 mo of age ... | 2003 | 12571141 |
| estrogen modulation of nmda-induced seizures in ovariectomized and non-ovariectomized rats. | the objective of this study was to examine the neuroprotective effects of estrogen in response to n-methyl-d-aspartate (nmda)-induced seizures in both male and female rats. thirty-eight long-evans rats were divided into five groups: ovariectomized females, non-ovariectomized females, ovariectomized females with estrogen replacement (10 microg 17beta-estradiol in 100 microl sesame oil), males given exogenous estrogen and males receiving no estrogen. using stereotaxic surgery, a cannula was placed ... | 2003 | 12576185 |
| simple physical treatment as an effective tool to improve the functional properties of rapeseed (brassica campestris var. toria) and sesame seed (sesamum indicum) meals. | dry and 24-h imbibed rapeseeds and sesame seeds were defatted with hexane, and freeze-dried powder was analysed for the functional properties of the meals. the water absorption capacity of the imbibed rapeseed meal and the fat absorption capacity of both the imbibed meals were higher than dry meals. protein solubility of the rapeseed meal was improved by imbibition and both the imbibed meals exhibited maximum protein solubility at ph 12. the rapeseed meal possessed better foaming properties and ... | 2002 | 12590740 |
| the analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine pivalate, in rats. | nalbuphine is an opioid-analgesic with agonist-antagonist properties. recently, we have synthesized a nalbuphine prodrug, nalbuphine pivalate. the aim of the present study was to evaluate the analgesic effect and the analgesic duration of this prodrug. | 2002 | 12596618 |
| role of ovarian progesterone and potential role of prostaglandin f2alpha and prostaglandin e2 in modulating the uterine response to infectious bacteria in postpartum ewes. | in sheep and cattle, the postpartum uterus is resistant to bacterial challenge until after corpora lutea develop. a 2 x 2 factorial arrangement of treatments was used to determine whether prostaglandins may mediate the effects of progesterone in transforming the postpartum uterus from resistant to susceptible. on d 14 postpartum, ewes (n = 6/group) were ovariectomized or sham ovariectomized, and the vena cava was catheterized for daily collection of uteroovarian-enriched blood. from d 15 to 20, ... | 2003 | 12597400 |
| effect of pygeum africanum tadenan on micturition and prostate growth of the rat secondary to coadministered treatment and post-treatment with dihydrotestosterone. | pretreatment with oral tadenan (tad) has been shown to possess a protective effect on bladder dysfunction-induced obstruction. we evaluated the functional influence of cotreatment and post-treatment with oral tad on the frequency/volume characteristics of micturition of conscious rats stimulated with exogenous dihydrotestosterone (dht) to induce experimental prostate growth. | 2003 | 12597984 |
| novel antioxidative metabolites in rat liver with ingested sesamin. | sesamin, a major lignan in sesame oil, is known to have many biological activities, especially protective effects against oxidative damage in the liver. as sesamin itself has no antioxidative properties in vitro, to elucidate the mechanism of its antioxidative effects, the reaction products of sesamin in rat liver homogenate were analyzed. the methylenedioxyphenyl moiety in the structure of sesamin was shown to be changed into a dihydrophenyl (catechol) moiety. the enzymatic reaction products in ... | 2003 | 12617602 |
| isolation and characterization of a myo-inositol 1-phosphate synthase cdna from developing sesame (sesamum indicum l.) seeds: functional and differential expression, and salt-induced transcription during germination. | a cdna (semips1) encoding myo-inositol 1-phosphate synthase (ec 5.5.1.4) (mips) has been characterized from sesame (sesamum indicum l. cv. dan-baek) seeds and its functional expression analyzed. the semips1 protein was highly homologous with those from other plant species (88-94%), while a much lower degree of sequence homology (53-62%) was found with other organisms such as humans, mouse, algae, yeast, drosophila, bacteria and other prokaryotes. a yeast-based complementation assay in yeast muta ... | 2003 | 12624775 |
| changes in telomerase activity in experimentally induced atretic follicles of immature rats. | follicular atresia is characterized by apoptosis of granulosa cells, and telomerase plays an important role in the apoptotic process. to study the relationship between follicular atresia and telomerase activity, we investigated changes in telomerase activity and localization in experimentally induced atretic follicles of immature rats. immature female sprague-dawley rats received 15 iu equine cg (ecg) by subcutaneous injection. rats were killed under ether anesthesia at 2, 3, 4, or 5 days after ... | 2002 | 12625407 |
| estradiol valerate and alcohol intake: a comparison between wistar and lewis rats and the putative role of endorphins. | studies show that estrogens can influence alcohol consumption; however, findings are variable and an etiology remains unknown. furthermore, estrogen administration can alter several neurotransmitter systems implicated in alcohol consumption, including the beta-endorphin (beta-ep) system. the present studies investigate (a) whether estradiol valerate (ev) alters voluntary alcohol consumption in wistar and lewis rats, (b) if an effect of ev on drinking is associated with changes in hypothalamic or ... | 2003 | 12642176 |
| increase of viability of entrapped cells of lactobacillus delbrueckii ssp. bulgaricus in artificial sesame oil emulsions. | a technique was developed to protect lactic acid bacteria (lactobacillus delbrueckii ssp. bulgaricus) against simulated gastrointestinal conditions by encapsulation of bacterial cells within artificial sesame oil emulsions. purified sesame oil bodies consisting of approximately 99% oil, 0.5% phospholipid, and 0.5% protein were decomposed by heating at 70 degrees c for 1 h. the bacteria cultured in nonfat milk were encapsulated in artificial oil emulsions constituted with decomposed sesame oil bo ... | 2003 | 12647948 |
| estradiol alters afterdischarge threshold and acquisition of amygdala kindled seizures in male rats. | we have previously shown that estradiol (e(2)) can initially increase and then decrease kindle seizure parameters in amygdala kindled male rats. this study focuses on the effects of estradiol benzoate (eb) on afterdischarge (ad) threshold and electrical kindling acquisition in intact male rats. after implantation of tripolar and monopolar electrodes in amygdala and dura surface respectively, effects of eb on ad threshold and electrical kindling acquisition were investigated by daily injection of ... | 2003 | 12648754 |
| oilcakes as protein sources in supplementary diets for the growth of cirrhinus mrigala (ham.) fingerlings: laboratory and field studies. | five isonitrogenous diets (1-5) with 40% protein using oilcakes as protein sources were formulated and fed to cirrhinus mrigala fingerlings maintained both under laboratory and field conditions. water soaking of oilcakes for 24 h before incorporation in the diets helped in the reduction of antinutrient factors (phytase and tannins). live weight gain in fish fingerlings fed on a diet containing groundnut oilcake (gnoc) was significantly (p < 0.05) enhanced in comparison to the other dietary treat ... | 2003 | 12688472 |
| temporal association of ca(2+)-dependent protein kinase with oil bodies during seed development in santalum album l.: its biochemical characterization and significance. | calcium-dependent protein kinase (cdpk) is expressed in sandalwood (santalum album l.) seeds under developmental regulation, and it is localized with spherical storage organelles in the endosperm [anil et al. (2000) plant physiol. 122: 1035]. this study identifies these storage organelles as oil bodies. a 55 kda protein associated with isolated oil bodies, showed ca(2+)-dependent autophosphorylation and also cross-reacted with anti-soybean cdpk. the cdpk activity detected in the oil body-protein ... | 2003 | 12721377 |
| [cycling and balance of copper in farmland ecosystem of jianghan plain in hubei province]. | the cycling and balance of copper in 8 cropping systems, i.e., wheat-rice, rice-rice, rape-soybean, rape-peanut, wheat-sesame, wheat-cotton, pepper-cabbage and radish-eggplant in jianghan plain of hubei province were studied. the results showed that the main output of copper was crop harvesting, up to 85.9%-95.1% of total output, and the output of copper by field runoff and soil leaching was low. the main inputs of copper were organic fertilizer, rainfall, falldrop, and natural return. the input ... | 2003 | 12722442 |
| chronic administration of corticosterone impairs spatial reference memory before spatial working memory in rats. | corticosterone (cort), the predominant glucocorticoid in rodents, elevated for 21 days damages hippocampal subregion ca3. we tested the hypothesis that cort would impair spatial memory, a hippocampal function. in each of the three experiments, rats received daily, subcutaneous injections of either cort (26.8 mg/kg body weight in sesame oil) or sesame oil vehicle alone (veh). cort given for 21 or 56 days effectively attenuated body weight gain and reduced selective organ and muscle weights. all b ... | 2003 | 12737930 |
| methoxychlor modifies the ultradian secretory pattern of prolactin and affects its trh response. | methoxychlor (mtx) is an insecticide characterized by both estrogenic and antiandrogenic properties that may modify the secretory pattern of prolactin. the objective of the present work was to analyze mtx's effects on changes in the episodic secretion of prolactin induced by thyrotropin-releasing hormone (trh). | 2003 | 12761465 |
| distribution of zoosporic fungi in the mud of major egyptian lakes. | twenty-six identified and three unidentified species belonging to eight genera of zoosporic fungi were recovered from seventy-six mud samples of egyptian lakes using sesame seeds as baits. nineteen samples were collected along the borders of four major lakes. pythium, phytophthora and allomyces, yielded the highest spectra of zoosporic species, while aqualinderella, blastocladia and dictyuchus, had one species. pythium, aphanomyces, allomyces, aqualinderella, phytophthora and saprolegnia were th ... | 2003 | 12761768 |
| central administration of the neurotensin receptor antagonist sr48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. | tardive dyskinesia is a movement disorder that develops in 20-30% of patients treated with chronic neuroleptics. whilst the pathogenesis of tardive dyskinesia remains unclear, altered expression of neuropeptides in the basal ganglia has been implicated in its emergence. the peptide neurotensin is expressed in both dopamine d1 receptor-bearing neurons of the direct striatonigral pathway and dopamine d2 receptor-bearing neurons of the indirect striatopallidal pathway. increased levels of striatal ... | 2003 | 12770567 |
| decontamination of seeds for seed sprout production by high hydrostatic pressure. | garden cress, sesame, radish, and mustard seeds immersed in water were treated with high pressure (250, 300, 350, and 400 mpa) for 15 min at 20 degrees c. after treatment, percentages of seeds germinating on water agar were recorded for up to 11 days. of the seeds tested, radish seeds were found to be the most pressure sensitive, with seeds treated at 250 mpa reaching 100% germination 9 days later than untreated control seeds did. garden cress seeds, on the other hand, were the most pressure res ... | 2003 | 12800989 |
| immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus. | very little is known about the impact of selective estrogen receptor modulators (serms) on the brain. we examined the effects of tamoxifen (tamox) and the synthetic estrogen 17alpha-ethynylestradiol (ee) on estrogen-dependent gene expression and receptor binding in the female rat brain. both immediate and residual effects were examined in both the presence and absence of 17beta-estradiol. two groups of adult, ovariectomized, female rats (n=30 per group) were injected with tamox (5 mg/kg), ee (0. ... | 2003 | 12834913 |
| timing of oral glutamine on dmba-induced tumorigenesis. | a single dose of oral 7,12-dimethylbenz(a)anthracene (dmba) in pubertal rats causes breast tumors by 11 weeks and is associated with ablation of the normal gut glutathione (gsh) production for up to 4 weeks. we hypothesized that glutamine (gln), known to restore the gut gsh production inhibited by dmba, given only during this 4-week period, would prevent breast cancer initiation. | 2003 | 12842461 |
| the effect of ovariectomy and estradiol replacement on collagen and elastic fibers in the bladder of rats. | the authors quantified the collagen and elastic fibers in the bladder wall of ovariectomized rats with and without estradiol replacement. this study was conducted on 60 3-month-old wistar rats. group 1 remained intact; group 2 underwent bilateral ovariectomy and were sacrificed after 30 days; group 3 were sham operated and sacrificed after 30 days; group 4 had a bilateral ovariectomy and after 30 days were started on subcutaneous injections of 17beta-estradiol (10 microg/kg body weight) for 90 d ... | 2003 | 12851753 |
| delayed implantation induced by fadrozole hydrochloride in rats. | the effect of aromatase inhibitors on the implantation process is not well known. this study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (fad). continuous subcutaneous infusion of fad at 300 microg/day from day 1 (the day of sperm detection) through day 7 of pregnancy using a mini-osmotic pump was found to delay the initiation of implantation by 1 or 2 days with no negative effects on embryonic viability. ... | 2003 | 12878290 |
| classification of edible oils by employing 31p and 1h nmr spectroscopy in combination with multivariate statistical analysis. a proposal for the detection of seed oil adulteration in virgin olive oils. | a combination of (1)h nmr and (31)p nmr spectroscopy and multivariate statistical analysis was used to classify 192 samples from 13 types of vegetable oils, namely, hazelnut, sunflower, corn, soybean, sesame, walnut, rapeseed, almond, palm, groundnut, safflower, coconut, and virgin olive oils from various regions of greece. 1,2-diglycerides, 1,3-diglycerides, the ratio of 1,2-diglycerides to total diglycerides, acidity, iodine value, and fatty acid composition determined upon analysis of the res ... | 2003 | 12952424 |
| oral testosterone-triglyceride conjugate in rabbits: single-dose pharmacokinetics and comparison with oral testosterone undecanoate. | development of a safe and effective oral form of testosterone has been inhibited by the rapid hepatic metabolism of nonalkylated androgens. since triglycerides are absorbed via lymphatics and bypass the liver, we hypothesized that a testosterone-triglyceride conjugate (ttc) might allow for safe and effective oral testosterone therapy. therefore, we studied the single-dose pharmacokinetics of oral administration of ttc in rabbits. female new zealand rabbits were administered 2, 4, or 8 mg/kg of t ... | 2003 | 12954663 |
| protective effects of sesamin and sesamolin on hypoxic neuronal and pc12 cells. | reactive oxygen species (ros) are important mediators of a variety of pathological processes, including inflammation and ischemic injury. the neuroprotective effects of sesame antioxidants, sesamin and sesamolin, against hypoxia or h2o2-induced cell injury were evaluated by cell viability or lactate dehydrogenase (ldh) activity. sesamin and sesamolin reduced ldh release of pc12 cells under hypoxia or h2o2-stress in a dose-dependent manner. dichlorofluorescein (dcf)-sensitive ros production was i ... | 2003 | 13130514 |
| effects of testosterone, sesame oil, and castration on tissue respiration of male rats exposed to cold. | 1957 | 13453456 | |
| influence of estradiol-17-beta, progesterone and hydrocortisone on 3-methylcholanthrene-induced mammary cancer in intact and ovariectomized sprague-dawley rats. | 1963 | 14068828 | |
| the metabolism of mucopolysaccharides. i. adrenal steroids and the synthesis of glucosamine-6-phosphate. | 1963 | 14083978 | |
| dietary protein level and the turnover rate of tissue proteins in rats. | 1963 | 14101006 | |
| deposition of benzo(a)pyrene in mouse fat after oral administration. | 1964 | 14115696 | |
| skin response to solenamine, a hemolytic component of fire-ant venom. | 1963 | 14156164 | |
| effects of sex steroids on the choline acetylase activity in the hypothalamus of female rats. | 1964 | 14168328 | |
| a study of the uterine cervix of the mouse. | 1964 | 14218417 | |
| inhibitory effect of testosterone on luteinizing hormone secretion in immature and adult rats. | 1965 | 14268458 | |
| action of fats and linoleic acid on intestinal synthesis of thiamine in thiamine-deficient rats. | 1965 | 14290858 | |
| the supplementary value of certain processed protein foods based on blends of groundnut, soya-bean, sesame, chick-pea (cicer arietinum) flours and skim-milk powder to a maize--tapioca diet. | 1962 | 14452512 | |
| short-term estrogen treatment in ovariectomized rats augments hippocampal acetylcholine release during place learning. | estrogen modulates learning and memory in ovariectomized and naturally cycling female rats, especially in tasks using spatial learning and navigation. estrogen also modulates cholinergic function in various forebrain structures. past studies have shown positive correlations between hippocampal ach output and performance on hippocampus-dependent tasks. the present study examined whether estradiol replacement would potentiate hippocampal ach release during place learning. in vivo microdialysis and ... | 2003 | 14521873 |
| the effects of sex steroids on the formation of gap junctions between folliculo-stellate cells; a study in castrated male rats and ovariectomized female rats. | we investigated the relationship between gap junction formation and the sex steroids testosterone, progesterone and 17beta-estradiol in the anterior pituitary glands of castrated male rats and ovariectomized female rats. male and female 30-day-old wistar-imamichi strain rats were castrated or ovariectomized, and 30 days later they were subcutaneously injected with the above sex steroids. they were divided into six groups according to the injected materials: sesame oil (control), testosterone, pr ... | 2003 | 14527164 |
| [antitumor effect of alcohol extract from sesamum indicum flower on s180 and h22 experimental tumor]. | to investigate the antineoplasm effect of extract from sesamum indicum l. flower. | 2003 | 14528695 |
| effect of sesame antioxidants on lps-induced no production by bv2 microglial cells. | sesame antioxidants have been shown to inhibit lipid peroxidation and regulate cytokine production. in this study, we focused on the effect of sesamin and sesamolin, on nitric oxide (no) induction by lipopolysaccharides (lps) in the murine microglial cell line bv-2 and rat primary microglia. the results showed that sesamin and sesamolin significantly inhibited no production, inos mrna and protein expression in lps-stimulated bv-2 cells. sesamin or sesamolin significantly reduced lps-activated p3 ... | 2003 | 14534426 |
| use of folk remedies among patients in karachi pakistan. | the concept that food is medicine is being practiced in certain parts of the world, with positive outcomes on health of the population. we have such practice in pakistan but it needs to be brought in line with the available scientific evidence. | 2003 | 14552245 |
| rhoa induction by functional overload and nandrolone decanoate administration in rat skeletal muscle. | the regulation of skeletal muscle regeneration and growth in response to functional overload is a coordinated interaction of mechanical and endocrine signaling pathways. this study's purpose was to determine if rhoa expression and activity in rat plantaris muscle was induced by functional overload with or without anabolic steroid administration. male sprague dawley (125 g) rats were subjected to bilateral ablation of the gastrocnemius muscle for 3 and 21 days and treated with nandrolone decanoat ... | 2003 | 14556075 |
| fermented grain products, production, properties and benefits to health. | fermented foods such as japanese traditional food "miso (fermented soy bean paste)" have been shown to be rich source of micronutrients with the potential to prevent various human diseases. we have introduced effects of a new dietary supplement of fermented grain foods mixture containing extracts from wheat germ, soybeans, rice bran, tear grass, sesame, wheat, citrus lemon, green tea, green leaf extract and malted rice under the trade name of antioxidant biofactor (aob). chemical analysis of aob ... | 2003 | 14567925 |
| antioxidant and anti-inflammatory effects of a diet supplemented with sesamin on hepatic ischemia-reperfusion injury in rats. | the antioxidant and anti-inflammatory properties of sesamin (a non-fat constituent of sesame oil) have been attributed to an increased accumulation of dihomo-y-linolenic acid, a precursor of 1-series prostaglandins, and the decreasing production of proinflammatory 2-series prostaglandins and 4-series leukotrienes by inhibiting the delta-5 desaturase activity. we investigated the effects of a diet containing sesamin on hepatic ischemia-reperfusion injury in rats. | 2003 | 14571796 |
| increased production of antioxidative sesaminol glucosides from sesame oil cake through fermentation by bacillus circulans strain yus-2. | bacillus circulans strain yus-2 was isolated as the strongest antioxidant-producer in fermentation of sesame oil cake (soc, defatted residue yielded from sesame seed oil production). two major strong antioxidants from fermented soc were purified and identified as known sesaminol triglucoside and sesaminol diglucoside, however, our results demonstrated that the fermentation process with b. circulans yus-2 was highly effective to gain the extraction efficiency of the sesaminol glucosides. | 2003 | 14586130 |
| dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. | we have previously reported that dietary sesamin and sesaminol, major lignans of sesame seed, elevate the alpha-tocopherol concentration and decrease the thiobarbituric acid reactive substance (tbars) concentration in the plasma and liver of rats. in this study, the effects of dietary sesamin and sesaminol on the lipid peroxidation in the plasma and tissues of rats fed docosahexaenoic acid (dha, 22:6 n-3) were examined. male wistar rats (4-wk-old) were divided into the following six experimental ... | 2003 | 14598914 |
| the antinociceptive effect of a long-acting nalbuphine preparation in rabbits. | an analgesic with a long-lasting effect is particularly desirable to patients suffering from long-standing pain. the aim of this study was to evaluate the antinociceptive effect and duration of action of an oily dosage form of nalbuphine base and to see whether its effect could last longer compared with nalbuphine hcl. | 2003 | 14601195 |
| oral glutamine (aes-14) supplementation inhibits pi-3k/akt signaling in experimental breast cancer. | 7,12-dimethylbenz [a] anthracene (dmba) administration to pubertal rats causes breast tumors and inhibits glutathione (gsh) production. our previous results have established that oral glutamine (gln) supplementation significantly reduced tumor development, restored the depressed gsh production, and caused a significant decrease in the circulating levels of insulinlike growth factor-1 (igf-1). the present study was designed to investigate the involvement of the igf-1-activated phosphatidylinosito ... | 2003 | 14621121 |
| triclabendazole in the treatment of paragonimiasis skrjabini. | to observe triclabendazole effect on paragonimus skrjabini in experimentally infected rats,and to develop a new drug for treating paragonimiasis. | 2003 | 14642135 |
| effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats. | in the present study, we evaluated the relationship between the antihypertensive effect of sesamin, a lignan from sesame oil, and its antioxidative activity in deoxycorticosterone acetate (doca)-salt hypertensive rats. after a 5-week treatment period, systolic blood pressure was significantly elevated in normal diet-fed doca-salt animals compared with cases in sham-operated animals. sesamin feeding, tempol (a superoxide dismutase mimetic) treatment or antihypertensive drugs combination (triple t ... | 2003 | 14646174 |
| comparative analysis of expressed sequence tags from sesamum indicum and arabidopsis thaliana developing seeds. | sesame (sesamum indicum) is an important oilseed crop which produces seeds with 50% oil that have a distinct flavor and contains antioxidant lignans. because sesame lignans are known to have antioxidant and health-protecting properties, metabolic pathways for lignans have been of interest in developing sesame seeds. as an initial approach to identify genes involved in accumulation of storage products and in the biosynthesis of antioxidant lignans, 3328 expressed sequence tags (ests) were obtaine ... | 2003 | 14682612 |
| estradiol and testosterone modulate the anesthetic action of the gaba-a agonist thip, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat. | as sex steroids modify the number and distribution of brain gamma-aminobutyric acid (gaba)a receptor subunits, we investigated the potential modulation of anesthesia, induced by agents acting on the gabaa receptor, by estrogen and androgen. | 2004 | 14685643 |
| sesame oil protects against lipopolysaccharide-stimulated oxidative stress in rats. | the aim of this study was to determine the effects and the defense mechanisms of sesame oil on lipopolysaccharide-induced oxidative stress in rats. | 2004 | 14707583 |
| salmonella in sesame seed products. | in the context of an international outbreak of multiresistant salmonella typhimurium dt 104 that was correlated to the consumption of halvah ("helva," an asian candy made from sesame seed), we examined several sesame seed products for the occurrence of salmonella. of 117 ready-to-eat food items containing sesame, we isolated salmonellae from 11 (9.4%) samples. in addition to finding salmonella typhimurium dt 104 in the halvah involved in the outbreak, we also isolated different salmonella typhim ... | 2004 | 14717370 |
| methods for allergen analysis in food: a review. | food allergies represent an important health problem in industrialized countries. undeclared allergens as contaminants in food products pose a major risk for sensitized persons. a proposal to amend the european food labelling directive requires that all ingredients intentionally added to food products will have to be included on the label. reliable detection and quantification methods for food allergens are necessary to ensure compliance with food labelling and to improve consumer protection. me ... | 2004 | 14744677 |
| p-nonylphenol, 4-tert-octylphenol and bisphenol a increase the expression of progesterone receptor mrna in the frontal cortex of adult ovariectomized rats. | alkylphenols, such as p-nonylphenol (np) and 4-tert-octylphenol (op) and bisphenol a (bpa) are thought to mimic oestrogens in their action, and are called endocrine disrupters. we examined whether these endocrine disrupters affected progesterone receptor (pr) mrna expression in the adult female rat neocortex. in one experiment, at 12.00 h, ovariectomized rats were given a subcutaneous injection of 10 mg of np, 10 mg of op or 10 mg of bpa, or sesame oil alone as control. twenty-four hours after i ... | 2004 | 14763995 |
| value of corozo palm nut and sesame oil meals, bananas, a.p.f. and cow manure in rations for growing and fattening pigs. | 1951 | 14832163 | |
| comparative effects of flaxseed and sesame seed on vitamin e and cholesterol levels in rats. | flaxseed and sesame seed both contain more than 40% fat, about 20% protein, and vitamin e, mostly gamma-tocopherol. furthermore, both contain considerable amounts of plant lignans. however, flaxseed contains 54% alpha-linolenic acid, but sesame seed only 0.6%, and the chemical structures of flaxseed and sesame lignans are different. in this study, we investigated the differential effects of flaxseed and sesame seed on plasma and tissue gamma-tocopherol, tbars, and cholesterol concentrations. rat ... | 2003 | 14870927 |
| studies on mold lipase; comparative study of lipases obtained from molds grown on sesamum indicum. | 1952 | 14953422 | |
| [the effects of early intermittent high-dose estrogen treatment on bone structure of ovariectomized rats]. | the effects of various estrogen replacement protocols to prevent bone loss following ovariectomy have been the subject of many studies in rats. this study was designed to determine the effects of early intermittent high-dose estrogen replacement therapy, which has hitherto not been studied, on bone structure of ovariectomized rats. | 2003 | 14963397 |
| methoxychlor-induced atresia in the mouse involves bcl-2 family members, but not gonadotropins or estradiol. | methoxychlor (mxc) is an organochlorine pesticide that increases the rate of ovarian atresia. to date, little is known about the mechanism by which mxc induces atresia. because bcl-2 (an antiapoptotic factor), bax (a proapoptotic factor), gonadotropins, and estradiol are important regulators of atresia in the ovary, the purpose of this study was first to examine whether mxc-induced atresia occurred through alterations in bcl-2 or bax, and second, to examine the effect of mxc on gonadotropins, es ... | 2004 | 14973267 |
| effects of sesamin and capsaicin on the mrna expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes. | sesamin, a lignan in sesame seeds and sesame seed oil, and capsaicin, the pungent principle of hot red pepper, affect lipid metabolism. sesamin specifically inhibits delta5 desaturase activity in the mortierella alpina fungus and rat liver microsomes, however, the effects of sesamin and capsaicin on mrna expressions of delta6 and delta5 desaturases are not still clear. in this study, we investigated the effects of sesamin and capsaicin on the desaturation indexes of delta6 [(gamma-linolenic acid ... | 2003 | 14974737 |
| progesterone promotes oocyte maturation, but not ovulation, in nonhuman primate follicles without a gonadotropin surge. | during the periovulatory interval, intrafollicular progesterone (p) prevents follicular atresia and promotes ovulation. whether p influences oocyte quality or maturation and follicle rupture independent of the midcycle gonadotropin surge was examined. rhesus monkeys underwent controlled ovarian stimulation with recombinant human gonadotropins followed by a) experiment 1: an ovulatory bolus of hcg alone or with a steroid synthesis inhibitor (trilostane, trl), or trl + the progestin r5020; or b) n ... | 2004 | 14985242 |
| cloning, functional expression, and characterization of cystatin in sesame seed. | a cdna fragment encoding cystatin, a cysteine protease inhibitor, was obtained from maturing sesame seeds. the clone was constructed in a nonfusion or fusion vector and then overexpressed in escherichia coli. the recombinant cystatins were found in the soluble fraction of cell extract and were demonstrated to be functionally active in a reverse zymographic assay. the corresponding endogenous 22 kda cystatin of low abundance in mature seeds was purified to homogeneity via a papain-coupling affini ... | 2004 | 14995145 |
| phytoestrogen genistein decreases contractile response of aortic artery in vitro and arterial blood pressure in vivo. | to determine the mechanisms of effects of phytoestrogen genistein on the contracted rabbit aortic arteries in vitro, and observe the effect of genistein and 17-beta estradiol on mean arterial pressure (map) in ovariectomized (ovx) rats. | 2004 | 15000884 |
| antinociceptive effect of a novel long-acting nalbuphine preparation. | a long-acting analgesic may be particularly desirable in patients suffering from long-lasting pain. the aim of the study was to evaluate the antinociceptive effect of a novel nalbuphine preparation and to determine its duration of action. | 2004 | 15003978 |
| species differences in the physiological activity of dietary lignan (sesamin and episesamin) in affecting hepatic fatty acid metabolism. | the effect of sesame (sesamum orientale) lignan preparation containing equivalent amounts of sesamin and episesamin on hepatic fatty acid metabolism was compared in rats, mice and hamsters. animals were fed on either a diet free of lignan or a diet containing 2 g lignan/kg for 15 d. the lignan preparation greatly increased hepatic activity and the mrna levels of enzymes involved in fatty acid oxidation, while it strongly down-regulated those of enzymes involved in lipogenesis in rats. in contras ... | 2004 | 15005823 |
| solubilizing excipients in oral and injectable formulations. | a review of commercially available oral and injectable solution formulations reveals that the solubilizing excipients include water-soluble organic solvents (polyethylene glycol 300, polyethylene glycol 400, ethanol, propylene glycol, glycerin, n-methyl-2-pyrrolidone, dimethylacetamide, and dimethylsulfoxide), non-ionic surfactants (cremophor el, cremophor rh 40, cremophor rh 60, d-alpha-tocopherol polyethylene glycol 1000 succinate, polysorbate 20, polysorbate 80, solutol hs 15, sorbitan monool ... | 2004 | 15032302 |
| parenteral sesame oil attenuates oxidative stress after endotoxin intoxication in rats. | sesame oil is regarded as a daily nutritional supplement to increase cell resistance to lipid peroxidation. the aims of this study were to examine the effects of parenteral sesame oil on oxidative stress and hepatic disorder induced by lipopolysaccharide and to determine the defense mechanisms involved in sesame oil-associated anti-oxidative effects in rats. oxidative stress was induced by lipopolysaccharide (5 mg/kg, intraperitoneally) and assessed by determination of lipid peroxidation. sesame ... | 2004 | 15036764 |
| sex differences in severity of inflammation-induced anorexia and weight loss. | food intake and body weight changes in response to induction of acute inflammation were examined in intact cycling females, ovariectomized females, and sham-operated male rats. in intact females, body weight and feeding responses were compared between rats in which inflammation was induced on day of estrus with rats in which inflammation was induced on day of diestrus. anorexia and weight loss were more severe in the female rats with inflammation induced on estrus day, which coincides with peak ... | 2004 | 15068655 |
| [a mouse model of hypospadias induced by flutamide]. | to establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology. | 2004 | 15080058 |
| effects of maitake mushroom fractions on blood pressure of zucker fatty rats. | a link exists between insulin resistance and many chronic disorders of aging including advancing-age. a safer means to prevent or, at least, slow the erosion of insulin sensitivity would provide a novel approach to better health. we compared the ability of a specific extract labeled fraction sx, as well as whole maitake powder, fraction es and fraction d of maitake to influence sbp and various pertinent biochemical parameters when given orally to zucker fatty rats, a model of insulin resistance ... | 2002 | 15080498 |
| effects of sesame oil on oxidative stress and hepatic injury after cecal ligation and puncture in rats. | oxidative stress is known to be involved in the development of organ failure and death in sepsis. sesame oil attenuates oxidative stress induced by endotoxin; however, whether sesame oil is still effective in rats with sepsis has never been investigated. the aim of the present study was to determine the effect of sesame oil on oxidative stress-associated hepatic injury in cecal ligation and puncture-induced rats with sepsis. we examined the effect of sesame oil (4 ml/kg daily for 1 week) on lipi ... | 2004 | 15087824 |
| the influence of chlordecone and oestrogen on the secretion of proteinaceous molecules of the mouse uterus. | ovariectomised mice were treated with sesame seed oil, oestradiol, or one of three different levels of the insecticide chlordecone (1, 1a, 3, 3a, 4, 5, 5a, 6-decachloro-octahydro-1, 3, 4-metheno-2h-cyclobuta[cd] pentalen-2-one). after 9 days of treatment, the uteri were injected with (35)s-methionine and radiolabelled proteins were flushed from uteri 4 h later. reproductive tract weights and the total amount of radioactivity in uterine flushings were measured. reproductive tract weights increase ... | 1987 | 15092725 |
| a novel medium for the enhanced cell growth and production of prodigiosin from serratia marcescens isolated from soil. | prodigiosin produced by serratia marcescens is a promising drug owing to its reported characteristics of having antifungal, immunosuppressive and antiproliferative activity. from an industrial point of view the necessity to obtain a suitable medium to simultaneously enhance the growth of serratia marcescens and the pigment production was the aim of this work. the usage of individual fatty acid as substrate in industries would be cost-effective in the long run and this paved the way for us to try ... | 2004 | 15113456 |
| hippocampal prosaposin changes during stress: a glucocorticoid-independent event. | several studies indicate that stress can produce remarkable effects on neurotrophic factors. in this regard, hippocampus is the most interesting structure of the brain because of its broad involvement in behavioral and neuroendocrine phenomena. in the present study, we investigated the effect of stress on hippocampal prosaposin, which is known to act as a neurotrophic and neuroprotective factor. rats subjected to restraint stress (120 min) had a significant and transient reduction of hippocampal ... | 2004 | 15132426 |
| method for bacterial expression and purification of sesame cystatin via artificial oil bodies. | a method was developed for production of sesame cystatin, a thermostable cysteine protease inhibitor. sesame cystatin was first expressed in escherichia coli as an insoluble recombinant protein fused to oleosin, a unique structural protein of seed oil bodies, by a short hydrophilic linker peptide. stable artificial oil bodies were constituted with triacylglycerol, phospholipid, and the insoluble oleosin-cystatin fusion protein. after centrifugation, the oleosin-cystatin fusion protein was exclus ... | 2004 | 15137862 |
| interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. | the interaction of sesamin, one of the most abundant lignans in sesame seed, and types of dietary fats affecting hepatic fatty acid oxidation was examined in rats. rats were fed purified experimental diets supplemented with 0% or 0.2% sesamin (1:1 mixture of sesamin and episesamin), and containing 8% of either palm, safflower or fish oil for 15 days. among the groups fed sesamin-free diets, the activity of various fatty acid oxidation enzymes was higher in rats fed fish oil than in those fed pal ... | 2004 | 15158759 |
| chronic treatment with progesterone but not medroxyprogesterone acetate restores the endothelial control of vascular tone in the mesenteric artery of ovariectomized rats. | to examine whether chronic administration of the natural hormone progesterone or a synthetic progestogen, medroxyprogesterone acetate, to ovariectomized rats affects the endothelial control of arterial tone in the isolated mesenteric artery. | 2004 | 15167304 |
| behavioral training interferes with the ability of gonadal hormones to increase ca1 spine synapse density in ovariectomized female rats. | estradiol benzoate (eb) has repeatedly been shown to increase hippocampal ca1 spine synapse density in ovariectomized female rats. although this increase has been assumed to enhance memory, a direct link between increased spine synapse density and memory has not been demonstrated. furthermore, while androgens, such as testosterone propionate (tp) and dihydrotestosterone (dht), also increase spine synapse density in females, their effects on memory have yet to be investigated. in the present stud ... | 2004 | 15182310 |
| influence of estradiol on insulin-like growth factor-1-induced luteinizing hormone secretion. | several studies suggest an interrelationship between estradiol (e2) and insulin-like growth factor-1 (igf-1) at the hypothalamic level. the present study was designed to discern if the capability of igf-1 to release lh and influence the timing of female puberty is influenced by e2. twenty-eight-day-old female rats were ovariectomized (ovex), then implanted with a third ventricular (3v) cannula. two weeks later, these animals received subcutaneous (s.c.) injection of oil, or either one or two inj ... | 2004 | 15196971 |
| divergent roles for estrogens and androgens in the expression of female goat sexual behavior. | we tested the hypothesis that the activation of the androgen receptor (ar) is required for full expression of female goat sexual behavior. once a week for 6 weeks, ovariectomized (ovx) females were given priming doses of progesterone 72 and 48 h before behavioral observation. estradiol (e(2); 100 microg), testosterone (t; 100 mg), or sesame oil was supplied 14 h before behavioral testing. six goats received the ar antagonist flutamide (9 mg/kg sc) 8 h before and 4 h after steroid injection. six ... | 2004 | 15215042 |
| effects of aluminum on phosphate metabolism in rats: a possible interaction with vitamin d3 renal production. | the effect of chronic aluminum (al) administration on the phosphorous (pi) metabolism of different target tissues was studied. male wistar rats received aluminum lactate for 3 months (5.75 mg/kg bodyweight of al, i.p., three times per week). the animals were studied at the end of the 1st, 2nd and 3rd month of treatment. they were housed individually in metabolic cages for 4 days to study pi and calcium (ca) balance. daily food and water intakes were recorded for all animals and urine and feces w ... | 2004 | 15221202 |