Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| treadmill exercise training augments brain norepinephrine response to familiar and novel stress. | in a test of hypothalamic-pituitary-adrenal (hpa) cortical and hypothalamic-pituitary-gonadal (hpg) interaction during familiar and novel stress, we previously reported that treadmill exercise training led to blunted plasma adrenocorticotrophin (acth) response to acute treadmill running but a hyper-responsiveness of acth after novel immobilization. in this follow-up analysis, we examined whether those results might be plausibly explained by a similar effect of treadmill exercise training on incr ... | 2000 | 10922511 |
| identification of a taurine transport inhibitory substance in sesame seeds. | an ethanol extract from sesame seeds inhibited the taurine uptake in human intestinal epithelial caco-2 cells. the uptake of such alpha-amino acids as leucine and glutamic acid was not inhibited by the extract, indicating that this inhibition is specific to the taurine uptake. the unknown inhibitor in the sesame extract was purifled by reversed-phase hplc by monitoring the inhibitory effect on taurine uptake. the isolated substance was identified as lysophosphatidylcholine, linoleoyl (lyso-pc), ... | 2000 | 10923786 |
| a cortisol surge mediates the enhanced polyamine synthesis in porcine enterocytes during weaning. | this study was conducted to determine whether a cortisol surge mediates the enhanced expression of intestinal ornithine decarboxylase (odc) in weanling pigs. piglets were nursed by sows until 21 days of age, when 40 pigs were randomly assigned into one of four groups (10 animals/group). group 1 continued to be fed by sows, whereas groups 2-4 were weaned to a corn and soybean meal-based diet. weanling pigs received intramuscular injections of vehicle solvent (sesame oil), ru-486 (a potent blocker ... | 2000 | 10938245 |
| androgens are neuroprotective in the dentate gyrus of adrenalectomized female rats. | neuroprotective effects of androgens have not been well-characterized, but there is evidence that 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol) has anti-seizure effects. to further examine androgens' neuroprotective effects, testosterone (t), dihydrotestosterone (dht), 3 alpha-diol (1.0 mg/kg sc daily), or sesame oil vehicle was administered to adrenalectomized or sham-operated, young, female long evans rats (n = 52). after seven days, animals were perfused and trunk blood was collecte ... | 2000 | 10938579 |
| possible estrogenic and/or antiandrogenic effects of methoxychlor on prolactin release in male rats. | methoxychlor (mtx) is a pesticide currently used as a substitute for dichloro-diphenyl-trichloroethane (ddt). this organochloride insecticide has some estrogenic properties, and may modify the feedback mechanisms of steroids on the hypothalamus and pituitary. this work was undertaken to explore the possible effects of mtx on the episodic prolactin release and to analyze whether these effects are mediated by dopamine (da), luteinizing hormone (lh), and/or testosterone. adult male sprague-dawley r ... | 2000 | 10959802 |
| effect of testosterone on the number of nadph diaphorase-stained nerve fibers in the rat corpus cavernosum and dorsal nerve. | to elucidate the effect of testosterone on penile nerve supply. | 2000 | 10962339 |
| effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor alpha in rats. | sesamin, a nonfat constituent of sesame oil, inhibits delta(5)-desaturase activity, resulting in accumulation of dihomo-gamma-linolenic acid (dgla), which displaces arachidonic acid (aa) and consequently decreases the formation of proinflammatory 2-series prostaglandins. | 2000 | 10966903 |
| experimental hyperprolactinemia in a rat model: alteration in centrally mediated neuroerectile mechanisms. | the purpose of this study was to induce hyperprolactinemia in adult male rats and determine its effect on the central and peripheral mediated neurogenic as well as myogenic mechanisms of erectile function/dysfunction in a rat model. the use of penile reflexes in awake animals was used to test the effect of both central and peripheral mechanisms. electrical stimulation of the cavernous nervous was used to test peripheral neural function and intracorporal injection of papaverine was used to test t ... | 2000 | 10982309 |
| sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity. | the effects of sesamol, a phenolic compound responsible for the high resistance of sesame oil to oxidative deterioration as compared with other vegetable oils, have been investigated after mutagen treatment in various strains of salmonella typhimurium. sesamol was shown to exhibit strong antimutagenic effects in the ames tester strains ta100 and ta102. the ta102 strain has been shown to be highly sensitive to reactive oxygen species. mutagenicity was induced by the generation of oxygen radicals ... | 2000 | 10986476 |
| luteinizing hormone secretion as affected by hypophyseal stalk transection and estradiol-17beta in ovariectomized gilts. | the objectives were to determine hypothalamic regulation of pulsatile luteinizing hormone (lh) secretion in female pigs and the biphasic feedback actions of estradiol-17beta (e(2)-17beta). in the first study, the minimum effective dosage of e(2)-17beta that would induce estrus in ovariectomized gilts was determined to be 20microg/kg body weight. in the second study, ovariectomized gilts were assigned randomly on day 0 to treatments: (a) hypophyseal stalk transection (hst), (b) cranial sham-opera ... | 2000 | 10989235 |
| effects of sesamin on altered vascular reactivity in aortic rings of deoxycorticosterone acetate-salt-induced hypertensive rat. | the effect of sesamin, a lignan from sesame oil, on altered vasodilator and vasoconstrictor responses in aortic rings from deoxycorticosterone acetate (doca)-salt-induced hypertensive rats, were examined. the systolic blood pressure after 5-weeks doca-salt treatment was 195.0+/-2.8 mmhg, which was much higher than that of sham-operated control animals (131.2+/-2.4 mmhg). sesamin feeding significantly suppressed the development of this hypertension (167.1+/-8.6 mmhg). acetylcholine (ach)-induced ... | 2000 | 10993201 |
| congenital anomalies in mice induced by etretinate. | we report on the experimental induction of anorectal malformations (arm) and other internal and external malformations in mouse fetuses induced by maternal administration of etretinate, a long-acting vitamin a analogue. the teratogen was administered to pregnant mice between the 7th and 10th gestational days (e7 and e10). the mice of the control group were given pure sesame oil on e9. we examined survival rates, crown-rump length, and the incidence of internal and external malformations, with pa ... | 2000 | 11034515 |
| effect of all-trans and 9-cis retinoic acid on growth and metastasis of xenotransplanted canine osteosarcoma cells in athymic mice. | to determine effects of all-trans and 9-cis retinoic acid (ra) on tumor growth and metastatic ability of canine osteosarcoma cells transplanted into athymic (nude) mice. | 2000 | 11039554 |
| cytochrome p4503a-dependent metabolism of tocopherols and inhibition by sesamin. | carboxychroman metabolites of the major dietary tocopherols are excreted in human urine, but the mechanism of their synthesis is unknown. we employed well-characterized inhibitors of specific cytochrome p-450 (cyp) enzymes to determine which form was likely involved in tocopherol side chain oxidation. ketoconozole (1.0 microm), a potent and selective inhibitor of cyp3a, substantially inhibited metabolism of gamma- and alpha-tocopherol in rat primary hepatocytes, and metabolism of gamma- and delt ... | 2000 | 11061988 |
| previous experience of diazepam withdrawal prevents the formation of a withdrawal-conditioned taste aversion: test of a blocking hypothesis. | prior experience of withdrawal from chronic diazepam treatment reduces the aversiveness of withdrawal when precipitated withdrawal is made the unconditioned stimulus in a conditioned taste aversion (cta) paradigm. accounts of the mechanism by which unconditioned stimulus pre-exposure reduces its effectiveness in cta postulate that unconditioned stimulus pre-exposure leads to the formation of associations with the environment, resulting in blocking of taste conditioning. we tested whether a block ... | 2000 | 11103913 |
| behavioral and neural toxicity of the artemisinin antimalarial, arteether, but not artesunate and artelinate, in rats. | three artemisinin antimalarials, arteether (ae), artesunate (as), and artelinate (al) were evaluated in rats using an auditory discrimination task (adt) and neurohistology. after rats were trained on the adt, equimolar doses of ae (25 mg/kg, in sesame oil, n=6), as (31 mg/kg, in sodium carbonate, n=6), and al (36 mg/kg, in saline, n=6), or vehicle (sodium carbonate, n=6) were administered (im) for 7 consecutive days. behavioral performance was evaluated, during daily sessions, before, during, an ... | 2000 | 11113482 |
| beneficial effects of flavonoids from sesamum indicum, emblica officinalis and momordica charantia. | flavonoids from sesamum indicum (gingili), emblica officinalis (gooseberry) and momordica charantia (bittergourd) were analysed for their biological activities. of the three sources, flavonoids isolated from emblica officinalis exerted the maximum beneficial action by eliciting highly potent hypolipidaemic and hypoglycaemic activities. moreover these flavonoids were effective in raising the haemoglobin levels in rats. | 2000 | 11113993 |
| immature rat uterotrophic assay of bisphenol a. | we used the immature rat uterotrophic assay to determine the estrogenicity of bisphenol a (bpa). we administered bpa (in sesame oil) to rats subcutaneously (sc; 0, 8, 40, and 160 mg/kg/day) or orally (0, 40, 160, and 800 mg/kg/day) for 3 days beginning on postnatal day (pnd) 18; rats were sacrificed 24 hr after the last administration. uterine wet, blotted, and relative weights increased in all groups given bpa sc. after oral administration, uterine relative weight increased in 160 and 800 mg/kg ... | 2000 | 11133394 |
| female steroid hormones modulate receptors for nerve growth factor in rat dorsal root ganglia. | calcitonin gene-related peptide (cgrp) is a vasodilatory peptide, and it is primarily synthesized in dorsal root ganglia (drg). plasma cgrp levels increase during pregnancy and with steroid hormones, and nerve growth factor (ngf) stimulates calcitonin/cgrp promoter and cgrp synthesis in drg. we previously showed that cgrp levels in drg were stimulated with steroid hormone treatments in vivo but not in vitro. thus, the stimulation of cgrp by these hormones may be indirect through the upregulation ... | 2001 | 11133691 |
| investigation of the teratogenic potential of a zingiber officinale extract in the rat. | the teratogenicity of ev.ext 33, a patented zingiber officinale extract, was examined in wistar spf rats according to glp guidelines. ev.ext 33 was administered by oral gavage in concentrations of 100, 333, and 1000 mg/kg, to three groups of 22 pregnant female rats from days 6 to 15 of gestation. for comparison, a fourth group received the vehicle, sesame oil. body weight and food and water intake were recorded during the treatment period. the rats were killed on day 21 of gestation and examined ... | 2001 | 11137381 |
| increased survival after cecal ligation and puncture in mice consuming diets enriched with sesame seed oil. | lignans that present in the nonfat portion of sesame seed oil (sso) can inhibit delta-5 desaturase activity, resulting in an increase in the accumulation of dihomo-gamma-linolenic acid and, subsequently, decrease the production of proinflammatory dienoic eicosanoids with a concomitant increase in the secretion of less inflammatory monoenoic eicosanoids. | 2001 | 11176174 |
| stress produced by gavage administration in the rat. | this research project examined the relationship between gavage administration of various vehicles and induction of the stress response, as defined by increased plasma corticosterone levels, in the rat. in addition, we assessed elicitation of clinical signs of distress and aspiration leading to airway/pulmonary changes. we studied various vehicles used in toxicology studies, including water, corn oil, and 1% methylcellulose/0.2% tween 80. male cd rats received a single gavage administration of ve ... | 2000 | 11178310 |
| sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia molt 4b cells. | the exposure of human lymphoid leukemia molt 4b cells to sesamolin, a component of sesame seed led to both growth inhibition and the induction of apoptosis. morphological change showing apoptotic bodies was observed in the cells treated with sesamolin. the fragmentation of dna by sesamolin to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. these findings suggest that growth inhibition of molt 4b cells by sesamolin resul ... | 2001 | 11254875 |
| evidence of sex hormone binding globulin binding sites in the medial preoptic area and hypothalamus. | we have demonstrated a high density of both radiolabeled progesterone and estradiol conjugated to bovine serum albumin binding sites in the medial preoptic area and hypothalamus. infusions of sex hormone binding globulin into the medial preoptic area of rats increased their female sexual receptivity similarly to the effect of estradiol conjugated to bovine serum albumin, suggesting sex hormone binding globulin acts at binding sites for estradiol conjugated to bovine serum albumin. in this study ... | 2001 | 11280718 |
| corn and sesame oils increase serum gamma-tocopherol concentrations in healthy swedish women. | we studied the effects of dietary intervention with three vegetable oils (linola, corn or sesame oil, all good sources of gamma-tocopherol) on absolute and relative concentrations of alpha- and gamma-tocopherol in human serum. the oils contained only small amounts of linolenic acid but varying amounts of oleic and linoleic acids, and they had different concentrations of alpha-tocopherol. forty healthy female students (mean age 26 y) were randomly assigned to one of three groups and consumed a di ... | 2001 | 11285325 |
| diverse biological activities of healthy foods. | diverse biological activities of 7 healthy foods [powdered pine needle, citrate-fermented sesame, powdered coffee, royal jelly, propolis, pollen and white sesame oil (extracted by super critical state (40 degrees c, 350 atmospheric pressure))] were investigated. the pine needle, sesame and powdered coffee was also extracted successively by ethanol and hot water, and lyophilized. the pine needle and coffee extracts, and propolis showed higher in vitro cytotoxic, bactericidal and oxidation activit ... | 2001 | 11286123 |
| pharmacologic, but not dietary, genistein supports endometriosis in a rat model. | endometriosis is a disease in which uterine tissue proliferates in extrauterine sites. using a surgical model to simulate endometriosis, we explored the potential for the phytoestrogen genistein, by injection and diet, to sustain endometriosis in rats. uterine tissue was attached to intestinal mesentery of 8-week-old sprague dawley rats. after 3 weeks, the rats were ovariectomized and the implants measured. following 3 weeks of daily injections or exposure to dietary genistein, animals were necr ... | 2001 | 11294976 |
| sesaminol from sesame seed induces apoptosis in human lymphoid leukemia molt 4b cells. | the exposure of human lymphoid leukemia molt 4b cells to sesaminol, a component of sesame oil led to both growth inhibition and the induction of apoptosis. morphological change showing apoptotic bodies was observed in the cells treated with sesaminol. the fragmentation of dna by sesaminol to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. these findings suggest that growth inhibition of molt 4b cells by sesaminol result ... | 2001 | 11295108 |
| lipid transfer proteins and 2s albumins as allergens. | plant lipid transfer proteins, a widespread family of proteins, have been recently identified as important food allergens. their common structural features, such as eight conserved cysteines forming disulfide bridges, basic isoelectric point and high similarity in amino acid sequence, are the basis of allergic clinical cross-reactivity. this has been demonstrated for the ltp allergens of the prunoideae subfamily, whose similarity is about 95% as demonstrated for the purified allergens of peach, ... | 2001 | 11298008 |
| effect of culture conditions on lipase production by fusarium solani in batch fermentation. | lipase (glycerol ester hydrolase ec 3.1.1.3.) from a brazilian strain of fusarium solani fsi has been investigated. the effect of different carbon sources and trace elements added to basal medium was observed with the aim of improving enzyme production. lipase specific activity was highest (0.45 u mg(-1)) for sesame oil. when this medium was supplemented with trace elements using olive oil, corn oil and sesame oil the lipase specific activity increased to 0.86, 1.89 and 1.64 u mg(-1), respective ... | 2001 | 11315806 |
| effects of estradiol-17beta administration on steady-state messenger ribonucleic acid (mrna) encoding equine alpha and lh/cgbeta subunits in pituitaries of ovariectomized pony mares. | the process of sexual recrudescence in the springtime in mares is characterized by renewal of follicular growth and acquisition of steroidogenic competence. concomitant with renewal of follicular steroidogenesis is re-establishment of lh biosynthesis and secretion. research results from our laboratory indicate that increased estradiol and lh secretion occur in close temporal association before the first ovulation of the year. therefore, the hypothesis tested in this experiment was that estrogen ... | 2001 | 11322236 |
| coconut fat and serum lipoproteins: effects of partial replacement with unsaturated fats. | the aim of the present study was to examine the effect of reducing saturated fat in the diet, or partly replacing it with unsaturated fat, on the serum lipoprotein profile of human subjects. the study had two intervention periods, 8 weeks (phase 1) and 52 weeks (phase 2). in phase 1, total fat was reduced from 31 to 25% energy (polyunsaturated fatty acids (pufa):saturated fatty acids (sfa) ratio increased from 0.2 to 0.4) by reducing the quantity of coconut fat (cf) in the diet from 17.8 to 9.3% ... | 2001 | 11348573 |
| noncovalent immobilization of bovine serum albumin on oxidized cellulose. | immobilization of bovine serum albumin (bsa) on oxidized cellulose (oc) containing carboxylic groups, a biocompatible and bioresorbable polymer, was investigated in water and different buffer solutions (ph 2-7) at 5 degrees c. the maximum amounts of bsa loaded on oc in ph 2, 3, 4, 6, and 7 buffer media were 9.82, 10.52, 8.86, 9.16, 6.05, and 2.69% (w/w), respectively. in water, the corresponding value was 9.82%. the release study was performed on powder, pellet and suspension (in castor and sesa ... | 2001 | 11358036 |
| bisphenol a inhibits testicular functions and increases luteinizing hormone secretion in adult male rats. | effects of a xenobiotic estrogen, bisphenol a (bpa), on reproductive functions were investigated using adult male rats. bpa was dissolved into sesame oil and injected s.c. every day (1 mg/rat) for 14 days. animals were killed by decapitation after the final administration of bpa, and the trunk blood, pituitary, and testes were collected. plasma concentrations of prolactin were dramatically increased and pituitary contents of prolactin were slightly increased in the bpa group compared to the cont ... | 2001 | 11361040 |
| nutritional quality of sesame seed protein fraction extracted with isopropanol. | the nutritional effect of diet containing decorticated sesame seed extracted with isopropanol (dss-iso) was evaluated on growth performance, food efficiency ratio, plasma and tissue lipid profile, plasma protein content, and erythrocyte membrane lipid profile of rats on a comparative basis with diets containing casein (control), soybean meal, and decorticated sesame seed extracted with hexane (dss-hex). rats fed a dss-iso-based diet showed body weight gain and food efficiency ratio similar to th ... | 2001 | 11368648 |
| effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver. | activities of enzymes involved in hepatic fatty acid oxidation and synthesis among rats fed sesame (sesamum indicum l.) differing in lignan content (sesamin and sesamolin) were compared. sesame seeds rich in lignans from two lines, 0730 and 0732, lines established in this laborary, and those from a conventional cultivar (masekin) were employed. seeds from the 0730 and 0732 lines contained sesamin and sesamolin at amounts twice those from masekin. sesame seeds were added at levels of 200 g/kg to ... | 2001 | 11368649 |
| pregnancy and steroid hormones enhance the systemic and regional hemodynamic effects of calcitonin gene-related peptide in rats. | calcitonin gene-related peptide (cgrp) is a potent vasodilator neuropeptide known to be involved in the regulation of vascular resistance. several lines of evidence suggest that cgrp plays a role in the vascular adaptations that occur during normal pregnancy; however, the effects of exogenous cgrp on systemic and regional hemodynamics during pregnancy remain unknown. therefore, the purpose of this study was to determine the hemodynamic effects of systemically administered cgrp in adult pregnant ... | 2001 | 11369608 |
| effects of olive, corn, sesame or peanut oil on the body weights and reproductive organ weights of immature male and female rats. | olive, corn, sesame or peanut oil which have been used as vehicles in the immature rat uterotrophic assay or hershberger assay, for detection of endocrine disrupting effects of environmental chemicals, was administered to ten immature female rats by subcutaneous injection from postnatal day (pnd) 21 for 3 or 7 days, and each oil was also administered to ten male rats from pnd 21 for 7 and 10 days. the body weights, and the weights of sex and sex accessory organs in female and male rats were meas ... | 2001 | 11381622 |
| [positive ratio of allergen specific ige antibodies in serum, from a large scale study]. | incidences of allergen specific ige antibodies in a large japanese population(n = 4,797,158) were studied. sera from patients were collected in our laboratories during 1994-1998, and assayed with pharmacias cap system feia. values greater than 0.70 ua/ml(score 2) were considered positive. japanese cedar pollen showed the highest ige response(positive ratio), followed by house dust, and dust mite. among food allergens, apple had the highest response, followed by sesame seed, egg white, potato, an ... | 2001 | 11391952 |
| effect of antioxidants on l-glutamate and n-methyl-4-phenylpyridinium ion induced-neurotoxicity in pc12 cells. | the neuropathology associated with parkinson's disease within and around the substantia nigra is thought to involve excessive production of free radicals, dopamine autoxidation, defects in the expression of glutathione peroxidase, attenuated levels of reduced glutathione, altered calcium homeostasis, excitotoxicity and genetic defects in mitochondrial complex i activity. while the neurotoxic mechanisms are vastly different for excitotoxins and n-methyl-4-phenylpyridinium ion (mpp+), both are tho ... | 2001 | 11405259 |
| effects of estradiol on glucoprivic transactivation of catecholaminergic neurons in the female rat caudal brainstem. | hyperphagic and hypothalamic neuroendocrine responses to acute glucose deprivation are modified by the ovarian steroid estradiol (e). observations of genomic activation of catecholaminergic (ca) neurons in the hindbrain lateral reticular nucleus, nucleus of the solitary tract, and area postrema (ap) by glucopenia support their potential function in pathways mediating regulatory effects of this metabolic challenge within the brain. expression of e receptors by these cells suggests that their acti ... | 2001 | 11408778 |
| inhibition of 5alpha-reductase enzyme or gaba(a) receptors in the vmh and the vta attenuates progesterone-induced sexual behavior in rats and hamsters. | progesterone (p) to the ventromedial hypothalamus (vmh) and the ventral tegmental area (vta) of ovariectomized (ovx), estradiol benzoate (eb)-primed rats and hamsters produces female sexual behavior similar to that seen in proestrous, receptive rodents. because p's 5alpha-reduced metabolites can have facilitative effects on female sexual receptivity through actions at gaba(a)/benzodiazepine receptor complexes (gbrs), the role of 5alpha-reductase and gbrs in the vmh and the vta was investigated. ... | 2001 | 11434663 |
| intestinal zonulin: open sesame! | 2001 | 11454785 | |
| the endocrine disrupters butyl benzyl phthalate and bisphenol a increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats. | butyl benzyl phthalate (bbp) and bisphenol a (bpa), so-called endocrine disrupters, are known to mimic the action of estrogens: they are thus liable to influence reproductive functions. since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mrnas, i.e., progesterone receptor (pr) mrna, preproenkephalin (ppe) mrna and neurotensin (nt) mrna, in the hypothalamus and pituitary of adult ... | 2001 | 11474214 |
| effects of estrogen and progesterone on the expression of connexin-36 mrna in the suprachiasmatic nucleus of female rats. | to determine the effects of ovarian steroid hormones on gap junction communication in the suprachiasmatic nucleus (scn), we examined the effects of estrogen and/or progesterone on the expression of connexin-36 mrna in the scn and cerebral cortex (cx) of female rats. ovariectomized adult rats were injected with 20 microg 17beta-estradiol or sesame oil 48 h before sacrifice and further injected with 1.5 mg progesterone or sesame oil 24 h before sacrifice. northern blot revealed that estrogen signi ... | 2001 | 11489541 |
| estradiol treatment increases feeding-induced c-fos expression in the brains of ovariectomized rats. | the steroid hormone estradiol decreases meal size by increasing the potency of negative-feedback signals involved in meal termination. we used c-fos immunohistochemistry, a marker of neuronal activation, to investigate the hypothesis that estradiol modulates the processing of feeding-induced negative-feedback signals within the nucleus of the solitary tract (nts), the first central relay of the neuronal network controlling food intake, and within other brain regions related to the control of foo ... | 2001 | 11506987 |
| potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (d4) and the linear siloxane hexamethyldisiloxane (hmds) in immature rats using the uterotrophic assay. | the cyclic siloxane octamethylcyclotetrasiloxane (d4) and the linear siloxane hexamethyldisiloxane (hmds) have numerous industrial and consumer applications and thus have the potential for human exposure. the present study was undertaken to examine potential estrogenic and antiestrogenic activities of d4 and hmds. to address potential differences in sensitivity between rat strains the study used both sprague-dawley (sd) and fischer 344 (f-344) rats. estrogenicity of the test compounds was determ ... | 2001 | 11509742 |
| effect of 7,12-dimethylbenz[a]anthracene (dmba) on gut glutathione metabolism. | one mechanism of the mammary carcinogenesis of 7,12-dimethylbenz[a]anthracene (dmba) is thought to be the generation of reactive oxygen species known to play an important role in initiation and progression. we hypothesized that dmba would disrupt gut glutathione (gsh) metabolism and this disruption would correlate with mammary cell carcinogenesis. | 2001 | 11516216 |
| [teratogenicity study of 2,2,3,3,3-pentafluoro-1-propanol (5fp) in rats by oral administration]. | teratogenicity of 2,2,3,3,3-pentafluoro-1-propanol (5fp), an alternative cleaning agent for chlorofluorocarbon, was examined in rats. 5fp was diluted with sesame oil and given to pregnant rats (crj: wistar) by gavage once a day from day 7 to 17 of pregnancy at doses of 0, 250, 500 and 1000 mg/kg/day. the pregnant rats were sacrificed on day 20 of pregnancy and their fetuses were examined for malformation. in the pregnant rats, 5fp caused wheezing, salivation, ptosis, reduced body weight gain and ... | 2000 | 11534126 |
| oxygen insertion in sesamum indicum furanofuran lignans. diastereoselective syntheses of enzyme substrate analogues. | the furofuran lignans in sesame seed have an unusual oxygen insertion between their furan and aryl rings. in our continuing investigations on the isolation and characterization of the enzyme(s) involved, the diastereoselective syntheses of various substrate analogues for the oxygen insertion step were developed for future substrate specificity and inhibitor studies. this synthetic strategy also provided entry to so-called furofuranone epoxy-lignans, such as salicifoliol from bupleurum sp., and a ... | 1997 | 11540412 |
| estradiol increases glucagon's satiating potency in ovariectomized rats. | estradiol decreases meal size, food intake, and body weight in female rats. to investigate whether these effects of estradiol involve a change in the sensitivity of the signaling pathway through which pancreatic glucagon released during meals contributes to meal termination (satiation), glucagon or glucagon antibodies were infused via the hepatic portal vein in ovariectomized rats that were chronically treated with estradiol benzoate (2 microg/day sc) or vehicle alone (100 microl sesame oil). in ... | 2001 | 11557638 |
| effects of dietary sesame seeds on plasma tocopherol levels. | the tocopherols, the major vitamers of vitamin e, are believed to play a role in the prevention of human aging-related diseases such as cancer and heart disease, yet little is known concerning determinants of their plasma concentrations. evidence from animal studies suggests that the dietary source of gamma-tocopherol can significantly affect plasma levels of this tocopherol as well as its functional vitamin e activity. to determine whether plasma levels of tocopherols in humans are similarly al ... | 2001 | 11588904 |
| effect of chronic treatment with haloperidol on vasopressin release and behavioral changes by osmotic stimulation of the supraoptic nucleus. | chronic treatment with dopamine d2 blockers in schizophrenic patients has been proposed as one of the causes of polydipsia and water intoxication, but this conclusion is still controversial. to investigate the relationship between dopamine d2 blockers and these syndromes, we designed a behavioral and neurochemical study using hyperosmotic stimulation in the supraoptic nucleus (son) by microdialysis after chronic treatment with haloperidol in rats. animals were injected with haloperidol decanoate ... | 2001 | 11669458 |
| determination of the disappearance rate of iodine-125 labelled oils from the injection site after intramuscular and subcutaneous administration to pigs. | the rate of disappearance of clinically used vegetable oils, viscoleo, sesame oil, castor oil and isopropyl myristate, from the injection site after intramuscular (i.m.) or subcutaneous (s.c.) administration to pigs were determined by using a non-invasive gamma-scintigraphy method. all the oil vehicles were spiked with 2.5% (v/v) (125)i-triolein and six injections of 1.9 ml were given to each of 12 pigs. no significant difference (anova) in disappearance rate of each individual oil vehicle from ... | 2001 | 11672957 |
| in vivo inhibition of keratinocyte growth factor receptor expression by estrogen and antagonism by progesterone in the mouse mammary gland. | mammary gland development is regulated by complex interactions among mammogenic hormones and locally derived paracrine growth factors. in epithelial tissues, keratinocyte growth factor (kgf or fgf-7) originates in the stroma while its receptor (kgfr or fgfr2-iiib) is present only in the epithelium. previous work showed that estrogen but not progesterone could stimulate the synthesis of kgf in mammary stroma in vivo. the effects of 17 beta-estradiol and progesterone on kgfr expression in vivo wer ... | 2001 | 11691652 |
| dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil. | the metabolism of tocotrienol remains unclear. we studied the distribution of tocotrienol in rats fed the tocotrienol-rich fraction extracted from palm oil. we have previously shown that dietary sesame seeds markedly elevate the tocopherol concentration in rats. in this study, we also examined the effect of dietary sesame seeds on the tocotrienol concentration. in experiment 1, rats (4-wk-old) were fed the diet with alpha-tocopherol alone or with alpha- and gamma-tocotrienols. in experiment 2, t ... | 2001 | 11694614 |
| high levels of estradiol disrupt conditioned place preference learning, stimulus response learning and reference memory but have limited effects on working memory. | the present study investigated the effects of high levels of estradiol in female rats on four different radial arm maze tasks: the hippocampus-dependent spatial working-reference memory task; the prefrontal cortex-hippocampus dependent delayed win-shift task; the striatum-dependent cued win-stay task; and the amygdala-dependent conditioned place preference task. ovariectomized female rats were injected daily with either 10 microg of estradiol benzoate or sesame oil vehicle approximately 4 h prio ... | 2001 | 11704257 |
| effect of short-term calf removal at three stages of a follicular wave on fate of a dominant follicle in postpartum beef cows. | the hypothesis that ovulation in response to short-term (48 h) calf removal (cr) is dependent on the developmental stage of the dominant follicle was tested in two studies. the objective of exp. 1 was to characterize the fate of a dominant follicle following 48-h cr on d 2, 4, or 8 of a postpartum follicular wave. ovaries of 61 beef cows were examined daily by transrectal ultrasonography starting at d 20 to 21 postpartum. treatments were no cr (n = 14) and cr on d 2 (n = 12), 4 (n = 16), or 8 (n ... | 2001 | 11721849 |
| comparison of the lymphatic transport of a lipophilic drug from vehicles containing alpha-tocopherol and/or triglycerides in rats. | the applicability of alpha-tocopherol as a lymphotropic carrier for a highly lipophilic drug has been evaluated. transport to the intestinal lymph of the highly lipophilic model drug, lu28-179, in rats after administration to the stomach in an alpha-tocopherol emulsion was compared with lymphatic transport after administration of a sesame oil emulsion and an alpha-tocopherol/sesame oil emulsion. lymphatic transport of the triglycerides and of alpha-tocopherol was determined. a conscious rat mode ... | 2001 | 11732746 |
| dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. | chronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. for example, both stress and chronic administration of corticosterone produce dendritic atrophy in hippocampal neurons (woolley c, gould e, mcewen bs. 1990. exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. brain res 531:225-231; watanabe y, gould e, mcewen bs, 1992b. stress induces atrophy of apical dendrites of hippocampal ca3 pyramid ... | 2001 | 11745662 |
| sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. | the effect of sesamin, one of the most abundant lignans in sesame seed, on hepatic fatty acid synthesis was examined in rats. rats were fed experimental diets containing varying amounts (0, 0.1 and 0.2% for exp. 1 and 0, 0.2 and 0.4% for exp. 2, respectively) of sesamin for 15 days. the activity and gene expression of enzymes involved in fatty acid synthesis including acetyl-coa carboxylase, fatty acid synthase, atp-citrate lyase and glucose-6-phosphate dehydrogenase decreased as the dietary lev ... | 2001 | 11750882 |
| hypoglycemic effect of a hot-water extract from defatted sesame (sesamum indicum l.) seed on the blood glucose level in genetically diabetic kk-ay mice. | genetically diabetic (type ii) kk-ay mice, male and 5 weeks of age, were divided into one group of 12 mice that were fed on a basal (bas) diet and three groups of 6 mice each that were fed on the test diets for 4 weeks. each test diet contained 4.0% of the hot-water extract (hes) from defatted sesame (sesamum indicum l.) seed, 1.4% of the water eluent fraction (wfh) of hes or 0.7% of the methanol eluent fraction (mfh) of hes from a glass column packed with hp-20 resin. at the end of the feeding ... | 2001 | 11758931 |
| estrogenic regulation of hsp90 kd synthesis in rat urinary bladder. | the role of heat shock protein (hsp90 kd) has been investigated in regard to its association with steroid receptors. hsp90 kd may play a role in steroid receptor stabilization and activation. oophorectomized sprague-dawley rats (n = 25) were placed into five groups and injected subcutaneously with 30 microg beta-estradiol 17-benzoate in sesame oil, with one group injected with carrier oil (control). after estrogen administration, the rats were killed, and their bladders removed for immunostainin ... | 2001 | 11762796 |
| effects of vitamin e and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. | the preventive effects of sesamin, a lignan from sesame oil, and vitamin e on hypertension and thrombosis were examined using stroke-prone spontaneously hypertensive rats (shrsp). at 5 weeks of age the animals were separated into four groups: (i) a control group; (ii) a vitamin e group, which was given a 1,000 mg alpha-tocopherol/kg diet; (iii) a sesamin group, given a 1,000 mg sesamin/kg diet; and (iv) a vitamin e plus sesamin group, given a 1,000 mg alpha-tocopherol plus 1,000 mg sesamin/kg di ... | 2001 | 11768736 |
| testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-jun nh2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for alzheimer's disease. | we have shown previously that glycogen synthase kinase-3 beta (gsk-3 beta), cyclin-dependent kinase 5, and c-jun nh(2)-terminal kinase become overactivated and hyperphosphorylate tau in heat-shocked female rats. this hyperphosphorylation of tau is estrogen-independent, prevented by androgens, and similar to alzheimer's disease. in this study, ovariectomized (ovx) sprague-dawley rats (n = 75) received daily injections of 10 microg of 17 beta-estradiol benzoate (eb), or 250 microg of testosterone ... | 2002 | 11805297 |
| preparation and stability of agarose microcapsules containing bcg. | an emulsification/internal gelation method of preparing small-sized agarose microcapsules containing bacillus calmette-guerin (bcg) is reported. agarose microcapsules have been prepared by the emulsification of the hydrogel within a vegetable oil followed by its gelation due to the cooling of the system. four different oils (sesame, sweet almonds, camomile and jojoba) were assayed. the rheological analysis of the oils showed a newtonian behaviour, with viscosity values of 37.7, 51.2, 59.3 and 67 ... | 2002 | 11837978 |
| antithrombotic lipid minor constituents from vegetable oils. comparison between olive oils and others. | many epidemiological studies suggest that vegetable oils and especially olive oil present a protective effect against atherosclerosis. in this study, total lipids (tl) of greek olive oils and seed oils of four kinds, namely, soybean, corn, sunflower, and sesame oil, were separated into total polar lipids (tpl) and total neutral lipids (tnl) via a novel extraction procedure. tpl and tnl of olive oil were fractionated by hplc for further study. each lipid fraction from hplc separation along with t ... | 2002 | 11853496 |
| estrogen's effects on activity, anxiety, and fear in two mouse strains. | estrogen has effects on activity levels and emotional reactivity in both humans and rats. in a recent study conducted in ovariectomized (ovx) c57bl/6 (c57) mice we found that treatment with estradiol benzoate (eb) increased anxiety, fear learning, and running wheel activity relative to vehicle control (veh). the present study was conducted to examine the stability of these findings across mouse strains (c57 and swiss-webster; sw), to get a better sense of the magnitude of the anxiety response by ... | 2002 | 11853861 |
| effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeys. | gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. sex differences have also been observed in the antinociceptive effects of opioid agonists. these findings suggest that gonadal hormones may modulate opioid antinociception. | 2002 | 11862360 |
| suppressive action of orexin a on pulsatile luteinizing hormone secretion is potentiated by a low dose of estrogen in ovariectomized rats. | orexins are hypothalamic neuropeptides which stimulate luteinizing hormone (lh) secretion in estrogen- and progesterone-treated ovariectomized (ovx) rats and suppress it in ovx rats not treated with estrogen, suggesting a modulation by estrogen of the response to orexins. we examined the effects of orexin a on pulsatile lh secretion in ovx rats treated with a very small dose of estrogen so as to maintain the pulsatile secretion of lh. the estrogen treatment was done 24 h before the blood samplin ... | 2002 | 11914586 |
| simple physical treatment as an effective tool to improve the functional properties or rapeseed (brassica campestris var. toria) and sesame seed (sesamum indicum) meals. | dry and 24 h imbibed rapeseeds and sesame seeds were defatted with hexane and the resulting freeze-dried powder was analysed for the functional properties of the meals. water absorption capacity (wac) of imbibed rapeseed meal and fat absorption capacity (fac) of both the imbeded meals were higher than those for dry meals. protein solubility of rapeseed meals was improved by imbibition and both the imbibed meals exhibited maximum protein solubility at ph 12. rapeseed meal possessed better foaming ... | 2002 | 11939112 |
| steroleosin, a sterol-binding dehydrogenase in seed oil bodies. | besides abundant oleosin, three minor proteins, sop 1, 2, and 3, are present in sesame (sesamum indicum) oil bodies. the gene encoding sop1, named caleosin for its calcium-binding capacity, has recently been cloned. in this study, sop2 gene was obtained by immunoscreening, and it was subsequently confirmed by amino acid partial sequencing and immunological recognition of its overexpressed protein in escherichia coli. immunological cross recognition implies that sop2 exists in seed oil bodies of ... | 2002 | 11950969 |
| developmental effects of perinatal exposure to bisphenol-a and diethylstilbestrol on reproductive organs in female mice. | reproductive tract development is influenced by estrogen. the aim of this study was to determine the effects of an environmental estrogenic chemical bisphenol-a (bpa) on prenatal and postnatal development of female mouse reproductive organs. in the prenatal treatment group, bpa or the synthetic estrogen diethylstilbestrol (des) were given by subcutaneous (s.c.) injections to pregnant mice during gestational days 10-18. some offspring treated prenatally with 10 and 100 mg/kg bw bpa or 0.67 and 67 ... | 2002 | 11955941 |
| [testosterone induction of metallothionein in accessory genital organs of male domestic cats]. | orchidectomy of cats resulted in a decrease of metallothionein (mt) in the dorsolateral and ventral lobes of the prostate and in the urethral gland to 21.2% (p<0.01), 88.4% (p>0.05) and 18.5% (p<0.01) of those of intact domestic cats respectively. mt content in the dorsolateral lobe and urethral gland was not restored in orchidectomized cats injected with sesame oil. after injection of a single subcutaneous dose of 10 microg/kg bw of testosterone (t) for 3 d in succession, the mt contents in the ... | 1999 | 11972185 |
| dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol. | we showed previously that dietary sesame seed and its lignans elevate the tocopherol concentration in rats. to clarify their effect on tocopherol metabolism, we determined in this study the urinary excretion of 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (gamma-cehc), a gamma-tocopherol metabolite, in rats fed sesame seed or its lignans. rats were fed diets with or without sesame seed for 28 d in experiment 1, and for 1, 3 and 7 d in experiment 2. on d 28, dietary sesame seed elevated (p ... | 2002 | 11983822 |
| comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. | sesamin is one of the most abundant lignans in sesame seed. episesamin, a geometrical isomer of sesamin, is not a naturally occurring compound and is formed during the refining process of non-roasted sesame seed oil. we compared the physiological activities of these compounds in affecting hepatic fatty acid metabolism in rat liver. rats were fed either a control diet free of lignan or diets containing 0.2% of sesamin or episesamin for 15 days. these lignans increased the mitochondrial and peroxi ... | 2002 | 12015159 |
| developmental exposure to polychlorinated biphenyls affects sexual behavior of rats. | polychlorinated biphenyls (pcbs) are persistent environmental contaminants that have the potential to disrupt reproduction through a variety of different pathways. in the present study, we investigated the effects of fetal and lactational pcb exposure on reproductive behavior in male and female laboratory rats. these pregnant rats were injected daily with either 2,4,2',4'-tetrachlorobiphenyl (pcb 47) at the dosage of 1 or 20 mg/kg body weight or 3,4,3',4'-tetrachlorobiphenyl (pcb 77) at the dosa ... | 2002 | 12020734 |
| effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin e concentrate rich in tocotrienols. | we have shown that sesame lignans added to rat diet resulted in significantly greater plasma and tissue concentrations of alpha- and gamma-tocopherol concentrations in supplemented rats than in rats without supplementation. in the present studies we examined whether sesaminol, a sesame lignan, enhances tocotrienol concentrations in plasma and tissues of rats fed diets containing a tocotrienol-rich fraction of palm oil (t-mix). in experiment 1, effects of sesaminol on tocotrienol concentrations i ... | 2002 | 12030315 |
| evidence for [1,5] sigmatropic rearrangements of cla in heated oils. | linoleic acid was heated at 200 degrees c under helium. analysis of degradation products by gc on a long polar open tubular capillary column showed the presence of cla isomers. the identified mono trans cla isomers were cis-9,trans-11, trans-9,cis-11, trans-10,cis-12, cis-10,trans-1 2, trans-8,cis-10, and cis-11,trans-13 18:2 acids. oils containing different levels of linoleic acid (peanut, sesame seed, and safflower seed oils) were also heat treated, resulting in similar cla distributions. elut ... | 2002 | 12030325 |
| comparative study of three different methods for the determination of aflatoxins in tahini. | aflatoxins spiked at three different levels (6.5, 13.0, and 19.5 microg/kg) in tahini, a sesame butter, were analyzed by using three different methods: high-performance liquid chromatography (hplc), fluorometry, and enzyme-linked immunosorbent assay (elisa). an immunoaffinity column was used for cleanup and purification of extracts prior to detection by hplc and fluorometry. all methods were statistically evaluated for accuracy, precision, and simple correlations. additionally, 14 tahini samples ... | 2002 | 12033798 |
| butyl benzyl phthalate, an endocrine disrupter, inhibits pulsatile luteinizing hormone secretion under an insulin-induced hypoglycaemic state in ovariectomized rats. | butyl benzyl phthalate (bbp) and bisphenol a (bpa), termed endocrine disrupters, are known to mimic oestrogen in their actions, and therefore there is concern about their effect on reproductive functions. since it is reported that the inhibitory action of oestrogen on the pulsatile secretion of luteinizing hormone (lh) is enhanced under insulin-induced hypoglycaemia, whether this also applies to bbp and bpa was examined in the present study. in adult ovariectomized (ovx) rats, the pulsatile lh s ... | 2002 | 12047723 |
| in vivo investigation of progressive alterations in rat mammary gland tumors by near-infrared spectroscopy. | we have investigated mammary gland tissues of female rats treated with 7,12-dimethylbenz[a]anthracene in sesame oil by a near infrared (nir) spectroscopy finding that the dna and water contents in the cancerous tissues were larger than those in the normal tissues but that the lipid content in the former was less than that in the latter. with protein contents, however, little difference was observed between the two. thus, we used a lipid band around 1725 nm (the first overtone of n-alkane) and a ... | 2002 | 12054444 |
| gibberellin and auxin-indole production by plant root-fungi and their biosynthesis under salinity-calcium interaction. | rhizosphere and rhizoplane of fababean (vicia faba), melochia (corchorus olitorius), sesame (sesamum indicum) and soyabean (glycine max) plants are inhabited with fungi, mostly aspergillus flavus, a. niger, fusarium oxysporum, penicillium corylophilum, p. cyclopium, p. funiculosum and rhizopus stolonifer. all fungal species have the ability to produce gibberellin (ga) but f. oxysporum was found to produce both ga and indole-acetic acid (iaa). the optimum period for ga and iaa production by f. ox ... | 2002 | 12073817 |
| corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis. | prenatal stress strongly affects sexual dimorphism of male rats. much less information is instead available on the effects of postnatal stress on sexual maturation during the so-called stress hyporesponsive period (shrp). for this reason, we compared corticosterone-treated (cs; 10 mg/kg sc, suspended in sesame oil) or maternally separated pups (ms; 5 h/day in the first week of life) with control rats. control and ms pups also received sesame oil injections. the effects of these procedures on phy ... | 2002 | 12076728 |
| long-term effects of the mammary carcinogen 7,12-dimethylbenz(a) anthracene on hypothalamic gonadotropin-releasing hormone and its pituitary receptor gene expression, during the promotion stage, in female sprague-dawley rats. | a single intragastric administration of 7,12-dimethylbenz(a)anthracene (dmba) has been shown to induce mammary tumors in young cycling female sprague-dawley rats. the appearance of these tumors is preceded by a series of neuroendocrine disturbances, including attenuation of the preovulatory luteinizing hormone (lh) surge and amplification of the preovulatory 17beta-estradiol surge, and gonadotropin-releasing hormone (gnrh) released in vitro. in this study, we examined the hypothesis that dmba ad ... | 2002 | 12083628 |
| identification of sesame seed allergens by 2-dimensional proteomics and edman sequencing: seed storage proteins as common food allergens. | sesame seed allergy is becoming increasingly prevalent, probably because of its use in international fast-food and bakery products. despite this fact, few studies have focused on the identification of its major allergenic proteins. | 2002 | 12110835 |
| influence of testosterone on autotomy in castrated male rats. | sex-related differences exist in nociception and gonadal steroids influence the analgesic response in animals and humans. as we have shown previously, estrogen could modify autotomy in female rats using the sciatic nerve transection model. to further characterize the relationship between gonadal steroid and nociception, the role of testosterone on autotomy in sciatic nerve sectioned rats was investigated. twenty male rats were subjected to orchiectomy (orx). then ten rats received subcutaneous s ... | 2002 | 12150198 |
| serotonin modulates offensive attack in adolescent anabolic steroid-treated hamsters. | chronic anabolic-androgenic steroid (aas) treatment during adolescence facilitates offensive aggression in male syrian hamsters (mesocricetus auratus). the current study assessed whether adolescent aas-facilitated offensive attack was modulated by serotonin (5-ht) and if aas exposure during this developmental period influenced 5-ht innervation to areas of hamster brain implicated in aggressive behavior. in a first experiment, hamsters were administered high-dose aas throughout adolescence, and t ... | 2002 | 12151048 |
| methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. | methoxychlor (mxc) is currently used to protect agricultural products from insects. previous studies show that mxc adversely affects the ovary, but the target cells were not revealed by those studies. therefore, the purpose of this study was to test the hypothesis that mxc induces ovarian changes by adversely affecting the antral follicles and the ovarian surface epithelium in the mouse. to test this hypothesis, cycling female cd-1 mice (39 days) were dosed with mxc (8, 16, or 32 mg/kg/day), kep ... | 2002 | 12151644 |
| chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the epstein-barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. | resveratrol, sesamol, sesame oil and sunflower oil are known natural dietary components with intrinsic cancer chemopreventive potentials. as a part of our study of dietary constituents as potential cancer chemopreventive agents, we have assessed the anti-cancer potentials of these products in the promotion stage of cancer development employing the in vitro epstein-barr virus early antigen activation assay induced by the tumor promoter 12-o-tetradecanoylphorbol 13-acetate (tpa). further, we studi ... | 2002 | 12162952 |
| sesame oil attenuates multiple organ failure and increases survival rate during endotoxemia in rats. | to investigate the effects and the possible mechanism of sesame oil on multiple organ failure induced by lipopolysaccharide in rats. | 2002 | 12163806 |
| neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents. | the neurotoxicity of beta-arteether (ae) is related to drug accumulation in blood due to slow and prolonged absorption from the intramuscular injection sites. in this efficacy and toxicity study of ae, the traditional sesame oil vehicle was replaced with cremophore to decrease the accumulation and toxicity of ae. dihydroartemisinin (dqhs), a more toxic and active metabolite of ae, was also analyzed. when administered at a daily dosage of 25 mg/kg for seven days, blood accumulation of ae with ses ... | 2002 | 12201585 |
| progesterone inhibits rejection of xenogeneic transplants in the sheep uterus. | one of the proposed roles of progesterone is to prevent maternal immunological destruction of the allogeneic conceptus. here, it was demonstrated that progesterone allows survival of a xenotransplant placed in the uterine lumen. | 2002 | 12218378 |
| antihypertensive effect of sesamin. iv. inhibition of vascular superoxide production by sesamin. | we previously demonstrated the preventive effect of sesamin, a lignan from sesame oil, on the development of several experimental models of hypertension. in the present study, we explored the mechanisms underlying the antihypertensive effect of sesamin using the deoxycorticosterone acetate (doca)-salt rat hypertensive model. after a 5-week treatment period, aortic superoxide (o2-) production was measured in the lucigenin chemiluminescence assay. chemiluminescence signals significantly decreased ... | 2002 | 12230131 |
| lipids, proteins, and structure of seed oil bodies from diverse species. | oil bodies isolated from the mature seeds of rape (brassica napus l.), mustard (brassica juncea l.), cotton (gossypium hirsutum l.), flax (linus usitatis simum), maize (zea mays l.), peanut (arachis hypogaea l.), and sesame (sesamum indicum l.) had average diameters that were different but within a narrow range (0.6-2.0 [mu]m), as measured from electron micrographs of serial sections. their contents of triacylglycerols (tag), phospholipids, and proteins (oleosins) were correlated with their size ... | 1993 | 12231682 |
| uterine-ovarian biochemical and developmental interactions to the postimplantation treatment with a butadiene metabolite, diepoxybutane, in pregnant rats. | an industrial chemical used in synthetic rubber production, 1,3-butadiene, is toxic to reproduction in rats and mice. bioactivation of butadiene to reactive intermediates, i.e. diepoxybutane and other metabolites, is responsible for this toxicity. the present study examines the biochemical and developmental mechanisms of diepoxybutane at the feto-maternal placental axis during gestation. female sprague-dawley rats were administered four daily intraperitoneal doses of diepoxybutane in groups (0.2 ... | 2002 | 12242682 |
| studies on some feed additives giving partial protection against ochratoxin a toxicity in chicks. | significant protective effects of the feed additives: water extract of artichoke, sesame seed, roxazyme-g and l-beta phenylalanine against the growth inhibitory effect of ochratoxin a (ota) and associated pathomorphological changes were seen. similarly, there was less ota-induced decrease in serum total protein and increase of serum creatinine and urea in the chicks. whereas ota induced strong degenerative changes and an increase in weight of kidneys and liver as well as a decrease of the weight ... | 2002 | 12243862 |
| histological study on norethynodrel treated rat ovary. | in an attempt to disclose the antiovulatory mechanism of norethynodrel, a progestational compound having slight estrogenic action, a histological study of treated rat ovaries was made. 4 test animals were injected daily for 14 days with 1 mg of norethynodrel in .3 ml sesame oil. all were killed 24 hr after the last injection. ovaries of treated rats showed follicular degeneration (cystic atresia), interstitial cell degeneration, and cellular hypertrophy of lutein cells. immature follicles di ... | 1968 | 12254411 |
| cyclosporine attenuates the autonomic modulation of reflex chronotropic responses in conscious rats. | cyclosporine a (cya), an immunosuppressant drug, has been shown to attenuate the baroreflex control of heart rate (hr). this study investigated whether or not the cya-induced baroreflex dysfunction is due to alterations in the autonomic (sympathetic and parasympathetic) control of the heart. we evaluated the effect of muscarinic or beta-adrenergic blockade by atropine and propranolol, respectively, on reflex hr responses in conscious rats treated with cya (20 mg x kg(-1) x day(-1) dissolved in s ... | 2002 | 12269786 |
| changes in structure and function of the preputial glands following daily injections of estrone or testosterone propionate in ovariectomized, "normal" and neonatally estrogenized rats. | these experiments were undertaken to determine if there is any difference in response of the preputial glands to estrogen or androgen between neonatally estrogenized adult female rats when ovariectomized and normal female rats similarly ovariectomized. 23 sprague-dawley females were given daily injections of estrone for 20 days from day of birth. doses were 50 mcg in .2 ml sesame oil for the first 10 days and 100 mcg in .04 ml of oil for the next 10 days. these are referred to as estrogenize ... | 1970 | 12304872 |