Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| regulation of steroid 21-hydroxylation by 17 beta-estradiol in rat liver: in vivo and in vitro study. | in various extraadrenal organs, progesterone (p4) is converted to deoxycorticosterone (doc) by steroid 21-hydroxylation. to investigate the regulation of extraadrenal 21-hydroxylase activity by 17 beta-estradiol (e2), the following two experiments were performed. exp. 1). three-week-old male sd rats were testectomized (tx) and injected with e2 (1 mg) or sesame-oil s.c. sham rats were treated with sesame-oil. in these groups the serum concentration of doc and corticosterone (b), microsomal 21-hyd ... | 1993 | 7951505 |
| urinary enzyme excretion as a parameter for detection of acute renal damage mediated by n-(3,5-dichlorophenyl)succinimide (ndps) in fischer 344 rats. | the kidney has been identified as the specific target organ for in vivo exposure to an agricultural fungicide, n-(3,5-dichlorophenyl)succinimide (ndps). the goal of this study was to determine if urinary protein and enzyme excretion were sensitive, non-invasive markers for ndps-induced renal damage. the proximal tubular enzymes that were monitored were the brush-border enzyme alkaline phosphatase (alp) and the lysosomal enzyme n-acetyl-beta-d-glucosaminidase (nag). male fischer 344 (f344) rats w ... | 1994 | 7963241 |
| a comparison of the effects of repeated stressor exposures and corticosterone injections on plasma cholesterol, thyroid hormones and corticosterone levels in rats. | persistently elevated serum cholesterol (chol) levels have been observed in rats given repeated stressor exposures and fed a normal laboratory diet. to determine the relative contribution of persistent hormone changes in the hypothalamic-pituitary-adrenal (hpaa) and thyroid axes to persistent stress-induced chol elevations, the present experiment assessed the contribution of persistently elevated corticosterone (cort) from both endogenous and exogenous sources. groups of rats were exposed for 7 ... | 1994 | 7968235 |
| [improvement of protein quality of popped sorghum with soybean grain]. | the present study was carried out to evaluate the chemical composition and protein quality of popped sorghum by thermic dry processing. the chemical results indicated losses in the ether extract and increases in crude fiber. likewise, losses were found in the essential amino acids, lysine and tryptophan, of 26 and 45%, respectively. the loss in these amino acids was confirmed by biological studies in which the protein quality of the raw sorghum, based on a per was 32% of the casein value and of ... | 1993 | 8002702 |
| reproductive toxicity of butylated triphenyl phosphate and tricresyl phosphate fluids in f344 rats. | the effects of tricresyl phosphate (tcp) and butylated triphenyl phosphate (btp)-based hydraulic fluid on reproduction were studied in f344 rats using a modification of the national toxicology program's continuous breeding protocol. groups of breeding pairs received single daily oral doses of an equal volume of either 0, 0.6, 1.0 g btp/kg or 0.4 tcp/kg in sesame oil or 1.7 g neat btp/kg for up to 135 days. a naive control group allowed to breed, but not dosed or handled daily, demonstrated that ... | 1994 | 8050634 |
| effect of chronic haloperidol treatment on dopamine-induced inositol phosphate formation in rat brain slices. | the effects of chronic haloperidol administration on the accumulation of inositol phosphates were examined in rat brain slices pre-labeled with [3h]myo-inositol and incubated with various dopaminergic drugs. rats were treated with haloperidol-decanoate or its vehicle (sesame oil) for two, four or six weeks. dopamine and the selective d1 agonist, skf38393, induced a significant increase in lithium-dependent accumulation of [3h]inositol monophosphate (ip1) in the frontal cortex, hippocampus and st ... | 1994 | 8065524 |
| [occupational asthma caused by organic substances]. | occupational asthma (oa) to organic substances is frequently related to ige-dependent hypersensitivity. new etiological agents are latex and vegetal gums, in health care personnel as in carpet-making manufactures. bakers are exposed to numerous allergens: wheat and cereal flours, sesame and other seed proteins, alpha-amylase and other enzymes. alpha-amylase extracted from aspergillus orizae is a potent allergen. plant derived materials have been identified as allergens in the floral industry (fi ... | 1994 | 8079074 |
| cessation of the electrical activity of gonadotropin-releasing hormone pulse generator during the steroid-induced surge of luteinizing hormone in the rat. | neuronal activity in the mediobasal hypothalamus was recorded during the steroid-induced surge of luteinizing hormone (lh) in ovariectomized female rats by means of multiunit activity (mua) recording techniques. the day of subcutaneous implantation of estradiol-containing silastic tubing, which was done at 12.00 h, was designated as day 1, and progesterone (1 mg) dissolved in sesame oil was injected at 12.00 h on day 5. the hypothalamic mua and serum lh level were monitored between 10.00 and 20. ... | 1994 | 8084374 |
| mammary gland morphology and responsiveness to regulatory molecules following prenatal exposure to diethylstilbestrol. | female aci rats were exposed to diethylstilbestrol (des) in utero to evaluate the effects on the peri-pubertal mammary gland with respect to 1) mammary gland morphology, 2) sensitivity to natural and synthetic estrogens, and 3) sensitivity to endogenous epidermal growth factor (egf). pregnant rats were injected with vehicle (sesame oil) or des (total dose, 8.0 micrograms) on days 15 and 18 of gestation. des-exposed and control offspring were ovariectomized at 34 days of age and sacrificed at day ... | 1993 | 8102210 |
| progesterone and estradiol interaction in the regulation of rat uterine weight and estrogen receptor concentration. | autologous down-regulation of hormone receptors has been shown for several steroid hormones. we have previously shown estradiol (e2) regulates estrogen receptor (er) in ovariectomized (ovx) rats. these studies have been extended to investigate the interaction between progesterone (p) and e2 in the regulation of er and uterine weight. we implanted silastic capsules containing varying concentrations of e2 (0.0005 mg e2/ml to 5.0 mg e2/ml of sesame oil) into adult female sprague-dawley rats one wee ... | 1994 | 8108464 |
| early exposure to low levels of estradiol (e2) mitigates e2-induced conditioned taste aversions in prepubertally ovariectomized female rats. | 17 beta-estradiol (e2) can serve as a potent unconditioned stimulus in producing a conditioned taste aversion to saccharin in rats, with the effect being greater in males than in females. to determine whether the female's lower susceptibility to such conditioning is due, in part, to early experience with estrogen, we performed the following experiment. first, we pretreated groups of prepubertally ovariectomized female rats with either sesame oil (control group) or low doses of e2 (0.3, 0.75, or ... | 1994 | 8140166 |
| a slow release formulation for recombinant bovine interferon alpha i-1. | recombinant bovine interferon-alpha i1 (rboifn-alpha) has known antiviral and immunomodulatory effects which have been exploited to reduce clinical disease in a number of clinical situations including bovine respiratory diseases. a slow release rboifn-alpha formulation may be of value to reduce bovine respiratory disease under field conditions by extending the period of protection, and hence improving the prophylactic benefits of rboifn-alpha. in this report, we describe a formulation of rboifn- ... | 1994 | 8141591 |
| developmental changes in the gonadotropin releasing hormone neuron of the female rabbit: effects of tamoxifen citrate and pregnant mare serum gonadotropin. | developmental changes in immunostained gonadotropin releasing hormone neurons were demonstrated in female rabbits assigned to the following treatment groups: (i) tamoxifen citrate, 10 mg.kg-1 x day-1, in sesame seed oil (vehicle) (n = 24) or (ii) vehicle alone (control, n = 24) for 108 days; and (iii) 50 iu of pregnant mare serum gonadotropin on postnatal days 22 and 25 (n = 24) or vehicle on nontreatment days. treatments had no effect on the total number of immunostained cells, but there was a ... | 1993 | 8143234 |
| phytogrowth-inhibitory activities of 2-thiophenecarboxylic acid and its related compounds. | 2-thiophenecarboxylic acid (i) exhibited growth-inhibitory activity in five kinds of plants. in particular, i strongly inhibited the growth of the roots of lactuca sativa l. var. longifolia lam and echinochloa utilis ohwi et yabuno, even at the low concentration of 5.0 x 10(-3) m. furthermore, all of the i-related compounds (ii-v and vii-x) except for vi, showed more or less obvious inhibitory activity on the seeds of sesamum indicum l. compounds vii-x, in which the carboxyl group of i was repla ... | 1994 | 8148810 |
| a magnesium-deficient high fructose diet augments bone-sparing action of exogenous oestrogen in ovariectomized rats. | to investigate interactions between circulating oestrogen, high dietary fructose, and low dietary magnesium on bone mineral density and numbers of trabeculae, 10 week old ovariectomized (ovx) and sham-ovariectomized (sovx) rats were studied. the ovx animals were divided into three groups: one-third of the animals were injected with beta-oestradiol-3-benzoate dissolved in sesame oil twice a week; another one-third were injected with testosterone cypionate; and the remaining ovx and all of the sov ... | 1993 | 8155484 |
| interrelationship between thyroxine and estradiol on the secretion of thyrotropin-releasing hormone and dopamine into hypophysial portal blood in ovariectomized-thyroidectomized rats. | effects of thyroxine (t4) on the secretion of thyrotropin-releasing hormone (trh) and catecholamines into hypophysial portal blood and on the concentrations of arterial plasma thyroid-stimulating hormone (tsh) and prolactin (prl) in ovariectomized and thyroidectomized (ovx-tx) rats were studied. immediately after ovariectomy, rats were tx or sham tx. the ovx-tx rats were injected subcutaneously with estradiol benzoate (eb, 0.5 microgram/kg b.w.) or sesame oil, and t4 (20 micrograms/kg b.w.) or s ... | 1994 | 8159269 |
| acute n-(3,5-dichlorophenyl)succinimide nephrotoxicity in female fischer 344 rats. | the agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) is an established nephrotoxicant in male fischer 344 rats at i.p. doses of > or = mmol/kg. since gender differences often exist in the susceptibility to toxicants, the nephrotoxic potential of ndps was examined in female fischer 344 rats. rats (4-5/group) were administered ndps (0.1, 0.2, 0.4, or 1.0 mmol/kg, i.p.) or vehicle (sesame oil, 2.5 ml/kg) and renal function monitored for 48 h. at a dose of 0.1 mmol/kg, ndps had no eff ... | 1994 | 8160197 |
| pathogenesis of cholesteryl lipidosis of adrenocortical and ovarian interstitial cells in f344 rats caused by tricresyl phosphate and butylated triphenyl phosphate. | triaryl phosphates including tricresyl phosphate (tcp) and butylated triphenyl phosphate (btp) are organophosphates used in the commercial manufacture of plastics, lubricants, and hydraulic fluids. rat steroidogenic tissues such as adrenocortical (ac), ovarian interstitial (oi), and leydig cells use an intracellular pathway to store cholesterol (substrate for biosynthesis of steroid hormones) as cholesteryl ester (ce). this pathway and the pathway for uptake of serum cholesterol are less used in ... | 1993 | 8212010 |
| coconut oil and sesame oil affect lymphatic absorption of cholesterol and fatty acids in rats. | five groups of male wistar rats weighing approximately 200 g consumed 12 or 24% sesame oil or coconut oil diets or a control diet (14% corn oil) ad libitum for 4 wk. the thoracic ducts of these rats were cannulated, and a lipid emulsion containing [3h]cholesterol and [14c]oleic acid was given through a duodenal catheter. lymph was collected for 24 h and the isotopic tracers for cholesterol and fatty acid were measured. rats fed the 24% sesame oil diet had significantly lower lymphatic cholestero ... | 1993 | 8229300 |
| effect of formulation on the pharmacokinetics and efficacy of doramectin. | the pharmacokinetics of doramectin, a novel avermectin, were evaluated following parenteral administration in a range of oil-based formulations in an attempt to optimise the formulation. therapeutic and persistent efficacies against cooperia oncophora were also evaluated. this approach led to the identification of formulations based upon sesame oil and ethyl oleate which gave more prolonged doramectin plasma concentrations with no loss in therapeutic efficacy and improved persistent efficacy fol ... | 1993 | 8236734 |
| up-regulation of androgen receptor immunoreactivity in the rat brain by androgenic-anabolic steroids. | to characterize central nervous system changes that occur with anabolic steroid abuse in humans, immunocytochemical localization of androgen receptors in the brains of 10 intact and 10 castrated male rats was conducted after the administration of high levels of androgenic-anabolic steroids (aas; 14 daily injections of sesame oil or a cocktail of 2 mg/kg testosterone cypionate, 2 mg/kg nandrolone decanoate, and 1 mg/kg boldenone undecylenate). in normal intact oil-treated males, nuclear androgen ... | 1993 | 8242360 |
| lysine requirement of broiler chicks as affected by protein source and method of statistical evaluation. | 1. an experiment was designed to test if the lysine requirement, expressed as g lysine/kg cp, was the same for several protein sources. 2. groundnut meal, groundnut meal adjusted with indispensable amino acids or sesame meal supplied the dietary cp at 180 g/kg diet. increments of lysine (1.5 g/kg diet) were added to each of these diets. 3. the gain, food intake and food efficiency responses of broiler chicks were analysed using a quadratic equation and a two-slope method. an estimate of lysine r ... | 1993 | 8242410 |
| [effects of testosterone on smooth muscle in the isolated rabbit corpus cavernosum penis]. | it has been reported that there is no relationship between serum testosterone level and erectile function and that testosterone mainly acts on the brain and not on the penis. however, we have found that erectile dysfunction in some patients with low serum testosterone improved after androgen replacement therapy. we therefore studied the effects of testosterone on the contraction and relaxation of the corpus cavernosum penis. four groups of rabbits were studied over a similar time span. the testo ... | 1993 | 8255041 |
| effect of microsomal enzyme modulators on n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs)-induced nephrotoxicity in the fischer 344 rat. | we have previously reported that phenobarbital (pb) pretreatment enhances and piperonyl butoxide (pibx) pretreatment or cobalt chloride (cocl2) pretreatment decreases the nephrotoxicity induced by the model nephrotoxicant n-(3,5-dichlorophenyl)succinimide (ndps) in the fischer 344 rat. the objective of this study was to determine the effect of a microsomal enzyme inducer (pb) or microsomal enzyme inhibitor (pibx or cocl2) on a single intraperitoneal (i.p.) injection of n-(3,5-dichlorophenyl)-2-h ... | 1993 | 8266334 |
| in vivo induction of increased dna ploidy of mouse cervicovaginal epithelium by neonatal estrogen treatment. | the purpose of this study was to test the hypothesis that exposure to natural estrogen early in the development of hormone-dependent tissue induces a change in nuclear dna content. female balb/c mice were treated neonatally with daily s.c. injections of either 25 micrograms of 17 beta-estradiol (e2) in 0.02 ml of sesame oil (vehicle) or vehicle alone for 5 days. treatment was begun either within 15 h of birth or 6 days after birth. one set each of 10-day-old e2-treated and control mice received ... | 1993 | 8286586 |
| antiestrogen u23,469 induced alterations of catecholamine levels on plasma and central nervous system. | the effect of antiestrogen u23,469 administration in vivo on the concentration of dopamine, norepinephrine and epinephrine in the plasma, cerebral cortex and hypothalamus in ovariectomized rats was investigated. rats were treated with estradiol benzoate, progesterone and u23,469 in different doses, s.c., daily for 6 days. control group was injected with sesame oil. catecholamines were estimated by radioenzymatic assay. six days of u23,469, estradiol benzoate, progesterone or its combination alte ... | 1993 | 8292874 |
| inhibition of rat mammary carcinogenesis by inositol hexaphosphate (phytic acid). a pilot study. | since phytic acid (inositol hexaphosphate, insp6) and inositol (ins) have been demonstrated to have anti-tumor and anti-cell proliferative action in several experimental models of carcinogenesis, in a pilot study we have examined their effect on 7,12-dimethylbenz(a)anthracene (dmba)-induced rat mammary tumor model. starting a week prior to induction with dmba, the drinking water of female sprague-dawley rats was supplemented with either: 15 mm insp6, 15 mm ins, or 15 mm insp6 + 15 mm ins; a cont ... | 1993 | 8293426 |
| estrogen modulates the growth-associated protein gap-43 (neuromodulin) mrna in the rat preoptic area and basal hypothalamus. | growth-associated protein gap-43 is a membrane-bound phosphoprotein which has been implicated in axonal elongation and synaptogenesis. gap-43 has been detected in the developing and adult preoptic area and basal hypothalamus. since estrogen is thought to influence neuronal connectivity and synaptic remodeling in the hypothalamus, the present study investigated estrogen modulation of gap-43 mrna in the preoptic area and ventromedial nucleus of the adult hypothalamus. female rats were bilaterally ... | 1993 | 8321416 |
| effects of testosterone on the development of endometrial tumors in female rats. | long-term treatment of mature virgin female rats with a high dose of testosterone (24 weeks at a total dose of 300 mg) was associated with the development of endometrial adenomatous hyperplasia and resulted in a high incidence of adenocarcinoma when administered in combination with 7,12-dimethyl-benz[a]anthracene (dmba; 2 mg in 0.1 ml sesame oil) introduced into the uterine cavity. adenomatous hyperplasia occurred in all testosterone-treated rats, both with and without ovaries. testosterone may ... | 1993 | 8349175 |
| gadolinium-dtpa enhanced mri demonstrates uterine vascular changes associated with artificially induced decidualization and ovoimplantation in rats. | gadolinium-dtpa enhanced magnetic resonance (mr) imaging has been used to demonstrate uterine vascular changes during ovoimplantation and artificially induced decidualization in rats. evans blue dye and gd-dtpa were injected i.v. into rats 10 h after unilateral decidualization was induced by injection of sesame oil into the lumen of one uterine horn. animals were killed various times later and uteri were removed, t1-weighted proton imaging was performed, and mean image intensities for stimulated ... | 1993 | 8350726 |
| increased concentrations of atrial and plasma atrial natriuretic peptide in castrated male rats. | the effects of orchiectomy and testosterone replacement on the plasma concentration and the atrial stores of atrial natriuretic peptide (anp) were studied in the rats. male rats were orchiectomized (orc) three weeks before replacement with testosterone propionate (tp, 20 mg/ml/kg body weight) or sesame oil for five days. immunoreactive anp (ir-anp) in the extracted right atria and plasma of experimental rats was measured. plasma anp concentrations were 206 +/- 22, 927 +/- 151, and 264 +/- 61 pg/ ... | 1993 | 8355561 |
| alpha 1 adrenergic regulation of estrogen-induced increases in luteinizing hormone-releasing hormone mrna levels and release. | prazosin, an alpha 1 adrenergic antagonist, was used to examine the relationship between adrenergic inputs and the stimulatory effects of estrogen on lhrh mrna and release. bilateral cannulae were implanted just dorsal to the preoptic area (poa). estrous cycles were monitored daily by vaginal smears. on the morning of diestrus, each rat was ovariectomized and assigned to one of three treatment groups: control--injected with sesame oil (n = 5); surge--injected with estradiol benzoate (eb, 10 micr ... | 1993 | 8381912 |
| an investigation into the role of neutrophils in decidualization and early pregnancy in the rat. | possible roles for neutrophils in the response of sensitized rat uteri to a deciduogenic stimulus were investigated. ovariectomized rats were sensitized for the decidual cell reaction by the administration of estradiol and progesterone. sesame oil was injected into one uterine horn as a deciduogenic stimulus on the equivalent of day 5 of pseudopregnancy. neutrophil numbers in the endometrium, as determined by microscopy after application of the stimulus, were dependent on time and stimulation. v ... | 1993 | 8391331 |
| intratumoral chemotherapy with cisplatin in oily emulsion in horses. | twenty horses with 30 lesions were studied to evaluate the effects of intratumoral chemotherapy with cisplatin in sesame oil on equine sarcoids (n = 19), squamous cell carcinomas (n = 7), and squamous cell papillomas (n = 4). treatment consisted of 4 sessions of intratumoral cisplatin chemotherapy at 2-week intervals. a controlled-release formulation of cisplatin in sesame oil was used to limit drug egress from the injection site. mean dosage per session was 0.97 (+/- 0.17, sem) mg of cisplatin/ ... | 1993 | 8428832 |
| interrelationships between porcine somatotropin and dietary lysine on growth performance and carcass characteristics of finishing swine. | seventy-two barrows (initial weight = 57.1 kg) were used to determine the interrelationship between porcine somatotropin (pst) and dietary lysine and their effects on growth performance and carcass characteristics. pigs were injected daily in the extensor muscle of the neck with either 4 or 8 mg of pst and fed a pelleted corn-soybean meal-sesame meal diet (.8% lysine; 17.8% cp) or diets containing 1.0, 1.2, or 1.4% lysine provided by additions of l-lysine.hcl (2 x 4 factorial arrangement). contr ... | 1993 | 8463154 |
| estrogen-induced left ventricular chamber enlargement in ewes. | we studied the chronic effect of administration of a single large intramuscular dose of 17 beta-estradiol on left ventricular chamber size and output in the ewe. fourteen oophorectomized ewes were successfully instrumented and studied, with measurements made of left ventricular, aortic, right and left atrial pressures, left ventricular stroke volume, and left ventricular minor axis dimension. unanesthetized ewes were studied before and 1, 2, and 3 wk after intramuscular administration of 0.6 mg/ ... | 1993 | 8476027 |
| uterine extracellular fluid volume and blood flow after artificial uterine stimulation to rats differentially sensitized for the decidual cell reaction. | uterine extracellular fluid volume (ecfv) and blood flow (bf) were assessed after unilateral intrauterine injection of sesame oil to rats given either ideal sensitization for the decidual cell reaction or one of several forms of non-ideal sensitization. the study was intended to determine how changes in uterine ecfv and bf might contribute to the evans blue dye reaction that can be elicited during early decidualization. uterine ecfv was determined by the uterine volume of distribution of 51cr-ed ... | 1993 | 8485256 |
| dibromomethane and carbon monoxide in the rat: comparison of the cardiovascular and metabolic effects. | the goals of this study were to examine the cardiovascular and metabolic responses to a dihalogenated methane and to compare them to inhaled co. one group of male sprague-dawley rats received an i.p. injection of either 3 or 6 mmol kg-1 dibromomethane (dbm) diluted 1:3 with sesame oil. measurements of carboxyhemoglobin (cohb), rectal body temperature (bt), heart rate, systolic blood pressure (bp) and blood glucose and lactate concentrations were made at times 0, 30, 60, 120, 240, 360, 480, 600, ... | 1993 | 8486914 |
| estradiol induces plasticity of gabaergic synapses in the hypothalamus. | the number of axosomatic synapses on arcuate neurons of the adult rat hypothalamus fluctuates following the sequence of increasing circulatory estradiol during the ovarian cycle. to determine whether estrogen is affecting gabaergic synaptic contacts we studied the number of gaba-immunoreactive axosomatic synapses in adult ovariectomized rats injected either with 17 beta estradiol (100 micrograms/100 g body weight) or with sesame oil vehicle. the number of immunoreactive axosomatic synapses was s ... | 1993 | 8492911 |
| effect of n-(3,5-dichlorophenyl)-2-hydroxysuccinimide on renal function and hemodynamics in the anesthetized rat. | the experimental agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) is a nephrotoxicant in the fischer 344 rat. ndps induces nephrotoxicity via metabolic bioactivation to one or more metabolites. both n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs) and n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (ndhsa), oxidative metabolites of ndps, are more potent nephrotoxicants than the parent compound. preliminary studies in our laboratory indicate that altered renal hemodynamics may co ... | 1993 | 8497867 |
| effect of naloxone and pulsatile luteinizing-hormone-releasing hormone infusions on oestradiol-induced luteinizing hormone surges in immature gilts. | the aim of the study was to understand why immature 60-day-old gilts produce delayed low amplitude luteinizing hormone (lh) surges in response to oestradiol benzoate. in expt 1, gilts (n = 36) were challenged with oestradiol benzoate and subsequently received either no further treatment or were infused with saline or various doses of the opioid antagonist, naloxone, for 6-48 h during the expected lh surge (48-96 h after oestradiol benzoate). no differences were observed among groups in the magni ... | 1993 | 8501710 |
| gonadal steroids modulate the growth-associated protein gap-43 (neuromodulin) mrna in postnatal rat brain. | gonadal steroid hormone action during early postnatal life determines the growth and connectivity of certain neuronal populations in the hypothalamus. the results of recent studies indicate that steroid hormones modulate the growth-associated protein gap-43 mrna in the adult rodent hypothalamus. since gap-43 is concentrated in axonal growth cones and has been implicated in axonal elongation and synaptogenesis, the present study investigated the effect of various gonadal hormonal conditions on ga ... | 1993 | 8513551 |
| differential sensitivity of rat uterine growth and epithelium hypertrophy to estrogens and antiestrogens. | triphenylethylene antiestrogens are considered weak estrogen agonists based on their limited ability to induce estrogen responses, in particular uterine growth. we compared the uterotrophic activity of naturally occurring and synthetic estrogens with that of antiestrogens by quantitating uterine wet weight and hypertrophy in the uterine luminal and glandular epithelium. immature rats received five daily injections of either an estrogen (17 beta-estradiol [e2], diethylstilbestrol [des], or ethyny ... | 1993 | 8516342 |
| triglyceride uptake in muscles in rats. | exogenous lipid is assimilated with different priorities in adipose tissue regions and varies in the fasting and fed conditions. the quantitative role of uptake of lipid in muscle has not been evaluated. in order to examine the uptake in other than adipose tissues, u14c-oleic acid in sesame oil was administered orally to conscious rats, and lipid label measured after different times in serum, heart, liver, mesenteric, retroperitoneal, inguinal and epididymal fat pads, as well as in red and white ... | 1995 | 8521161 |
| tissue reaction and immunity in swine immunized with actinobacillus pleuropneumoniae vaccines. | these studies were done to develop a subunit vaccine for swine that would protect against disease, but not create unacceptable tissue reactions at the immunization site. swine were used to evaluate the local effects of subunit vaccines prepared from extracts of actinobacillus pleuropneumoniae serotype 1 containing one of a wide variety of adjuvants. the antigen was an anionic fraction of a saline extract of a. pleuropneumoniae (anex). the adjuvants used were vegetable oils (peanut, sesame, canol ... | 1995 | 8548692 |
| progesterone and oestrogen receptors in the decidualized mouse uterus and effects of different types of anti-progesterone treatment. | pseudopregnant mice were treated systemically with monoclonal anti-progesterone antibody (db3) (model 1), or progesterone receptor antagonists ru486 or zk98,299 (zk299) (model 2) on day 3 post coitum. on day 4, sesame oil was administered intraluminally into one uterine horn to induce decidualization. on day 7, the average mass of the oil-injected horn was 335.2 +/- 52.4 mg, eight times greater than that of the non-injected horn (40.8 +/- 5.3 mg; p < 0.001). after treatment with db3, ru486 or zk ... | 1995 | 8568763 |
| sesame seed and its lignans produce marked enhancement of vitamin e activity in rats fed a low alpha-tocopherol diet. | three series of experiments demonstrated that sesame seed and its lignans cause significant elevation of alpha-tocopherol content in rats. in experiment 1, 20% sesame seed (with a negligible amount of alpha-tocopherol) supplementing 10 (low), 50 (normal), or 250 (high) mg/kg alpha-tocopherol diets (protein and fat concentrations in diets were adjusted to 200 and 110 g/kg, respectively) all caused a significant increase of alpha-tocopherol in the blood and tissue of rats. in experiment 2, groups ... | 1995 | 8569430 |
| the neurosteroid 3 alpha, 5 apha-thp has antiseizure and possible neuroprotective effects in an animal model of epilepsy. | some anticonvulsant drugs may suppress seizures by enhancing activity of gabaergic systems. progesterone (p)'s anti-convulsant and neuroprotective effects may be due to the steroid's actions on gabaa-benzodiazepine receptor complexes (gbrs) rather than intracellular progestin receptors (prs), as many p metabolites have a greater effect in vitro on benzodiazepine binding and cl-flux than p, but poor affinity for prs. if p's actions are due to metabolism to a progestin more potent at gbrs, then sy ... | 1995 | 8574658 |
| characterization of the mycoplasmalike organism associated with witches'-broom disease of lime and proposition of a candidatus taxon for the organism, "candidatus phytoplasma aurantifolia". | witches'-broom disease of small-fruited acid lime (wbdl) is a severe disease caused by a mycoplasmalike organism (mlo) in the sultanate of oman and the united arab emirates. the wbdl mlo was characterized by studying its genome size, the sequences of its 16s ribosomal dna and the 16s-23s ribosomal dna spacer region, and hybridization profiles obtained by using wbdl mlo-specific probes. the size of the wbdl mlo genome is 720 kbp. genomic similarities with the mlos of sunhemp, sesame, and alfalfa ... | 1995 | 8590671 |
| subchronic toxicity evaluation of lewisite in rats. | health and exposure criteria have not been established for lewisite [dichloro(2-chlorovinyl)arsine], a potent toxic vesicant that reacts with the sulfhydryl groups of proteins through its arsenic group. sixty sprague-dawley rats of each sex, 6-7 wk old, were divided into 6 groups (10/group/sex) and gavaged with either 0, 0.01, 0.1, 0.5, 1.0, or 2.0 mg/kg of lewisite in sesame oil 5 d/wk for 13 wk. no significant dose-related change in body weight was observed. at the high dose, serum protein, cr ... | 1996 | 8600286 |
| intratumoral administration of carboplatin for treatment of squamous cell carcinomas of the nasal plane in cats. | to develop a slow-release carboplatin formulation for intratumoral administration to cats. | 1996 | 8633809 |
| nephrotoxicity of n-(3-bromophenyl)-2-hydroxysuccinimide: role of halogen groups in the nephrotoxic potential of n-(halophenyl) succinimides. | among n-(halophenyl)succinimides. n-(3,5-dichlorophenyl)succinimide (ndps) is a potent nephrotoxicant as well as an agricultural fungicide. although two chloride groups on the phenyl ring are essential to induce optimal nephrotoxicity, the role of halogen groups in ndps nephrotoxicity is not clear. in this study, n-(3-bromophenyl)-2-hydroxysuccinimide (nbphs) was prepared as a monohalophenyl derivative of n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs), an oxidative and nephrotoxicant metabol ... | 1996 | 8658556 |
| influence of hormone treatment on prostate growth and micturition characteristics of the rat. | the influence of dihydrotestosterone propionate (dht) and estradiol (e) on prostate growth and micturition was evaluated. complete studies were carried out on 49 sprague-dawley rats over a 14-day period. rats were divided into three groups: (1) controls, (2) dht, and (3) dht + e. all groups were injected daily with 0.1 ml of sesame oil, together with 1.25 mg/kg of dht for group 2 and 1.25 dht + 0.125 mg/kg e for group 3. physiological measurements of micturition were done weekly by subcutaneousl ... | 1996 | 8685052 |
| analysis of the relative biomechanical effects of alpha 1 and alpha 2 antagonists in modifying the compliance of the prostate and micturition parameters of the hormonally manipulated male rat. | the potential of the alpha 1 and alpha 2 antagonists to modify prostate compliance, and micturition characteristics of rats with hormonally enlarged prostates was studied. prostate growth was induced in sprague-dawley rats using dihydrotestosterone (dht) and estradiol (e) by daily subcutaneous injections of dht 1.25 mg/kg and e 0.25 mg/kg together with 0.1ml of sesame oil, as a vehicle, for a period of 3 weeks. a control group of six rats was used wherein the vehicle alone was administered. dose ... | 1996 | 8696360 |
| cloning of extracellular lipase gene from xanthomonas campestris pathovar sesami on to escherichia coli. | a lipase gene from x. campestris pv. sesami (strain xcs 1) causal agent of leaf spot disease of sesamum indicum, was cloned onto e. colt. xcs showed the presence of lip+ transformants on dye's medium with 1% glycerol as sole carbon source. the recombinant plasmids were isolated and when digested with eco r1, yielded 2 fragments with molecular weights 4.0 and 4.8 kb. thus a 8.8 kb insert dna fragment was obtained which showed lipase activity. | 1996 | 8698403 |
| a study of the luteolytic mechanism of the antiprogesterone ru486 during the late-luteal phase in pseudopregnant rats. | the purpose of this study was to examine the possible mechanism through which ru486 induces luteolysis during the late-luteal phase in pseudopregnant (psp) rats. psp rats received a subcutaneous injection of ru486 in sesame oil (5 mg/kg body weight) or sesame oil alone once a day between day 9 and day 11 of pseudopregnancy. serial blood samples were collected on days 5, 9, 10, 11 and 12 and assayed for progesterone content. to examine the possible action of ru486 through a uterine and/or a pitui ... | 1996 | 8708568 |
| modulation of immune responses by anabolic androgenic steroids. | anabolic androgenic steroids (as) have recently been placed on the food and drug administration's (fda's) list of controlled substances, because of the adverse effects seen in athletes taking accelerated dosages in attempts to enhance performance. reported deleterious effects on abusers include sterility, gynecomastia in males, acne, balding, psychological changes, and increased risks of heart disease and liver neoplasia. considering the roles of the immune and neuroendocrine systems and their i ... | 1995 | 8788115 |
| changes in interleukin-1 production of peritoneal macrophages during estrous cycle in golden hamsters. | the present study demonstrated the change in interleukin-1 (il-1) production of peritoneal macrophages during the estrous cycle in golden hamsters and discussed its possible roles in ovarian function. macrophages were collected from the peritoneal cavity at 0900 h on various days of the estrous cycle and incubated for 6 h in the presence of ovine pituitary lh (500 ng/ml). the il-1 concentration in the media was measured by bioassay with the a375s2 human melanoma cell line. the number of macropha ... | 1996 | 8793329 |
| enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat. | 4-vinylcyclohexene diepoxide (vcd) destroys small preantral (25-100 microns) ovarian follicles after repeated dosing in mice and rats. a previous study determined this follicular destruction is via apoptosis (physiological cell death). the purposes of this study were to examine the effects of vcd on amounts of mrna for several genes that might be involved in this ovotoxic response and to determine the specificity of this response for small preantral follicles. the genes of interest were bax, a c ... | 1996 | 8806858 |
| effects of ceruletide on perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine. | the effects of repeated administration of ceruletide (100 micrograms/kg/perday, i.p. for 3 days) on perioral movements and the striatal dopamine receptor adenylate cyclase system were examined in rats chronically treated with fluphenazine enanthate (fpz) (25 mg/kg i.m. every 3 weeks for 30 weeks) and sesame oil-treated (control) rats. after the tenth injection of fluphenazine, the rats started to display five types of perioral movements (teeth chattering, chewing, tongue protrusion, mouth openin ... | 1996 | 8815952 |
| exogenous oestrogen affects calcium metabolism differently from exogenous testosterone in ovariectomized or orchiectomized rats fed a high fructose diet severely deficient in magnesium. | to investigate interactions between sex hormones, dietary fructose, and a severe magnesium deficiency on calcium metabolism, 10 week old ovariectomized (ovx) female, and orchiectomized (orx) males rats were studied. the ovx and orx animals were divided into two groups: one half of the animals in each group was injected with beta-oestradiol-3-benzoate dissolved in sesame oil twice a week; the other half was injected with testosterone cypionate in sesame oil twice a week. all animals were pari-fed ... | 1996 | 8819091 |
| subchronic toxicity evaluation of sulfur mustard in rats. | occupational exposure criteria have not been established for sulfur mustard (bis(2-chlorethyl) sulfide), a strong alkylating agent with known mutagenic properties. seventy-two sprague-dawley rats of each sex, 6-7 weeks old, were divided into six groups (12 of each sex per group) and gavaged with 0, 0.003, 0.01, 0.03, 0.1 or 0.3 mg kg-1 sulfur mustard in sesame oil for 5 days a week for 13 weeks. no dose-related mortality was observed. a significant decrease (p > 0.05) in body weight was observed ... | 1996 | 8821670 |
| sex differences in estrogen receptor and progestin receptor induction in the guinea pig hypothalamus and preoptic area. | quantitative in vitro autoradiography was used to determine if regional sex differences in estrogen receptor (er) content and/or estrogen responsiveness, as indicated by an increase in progestin receptor (pr), are present in the adult guinea pig brain. adult male and female guinea pigs were gonadectomized 1 week before subcutaneous injection of 25 micrograms estradiol benzoate (eb)/kg body wt or the sesame oil vehicle. animals were killed by decapitation 44 h after injection. unoccupied prs, and ... | 1996 | 8828584 |
| antihypertensive effect of sesamin. ii. protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy. | we investigated the antihypertensive effect of sesamin, a lignan from sesame oil, using two-kidney, one-clip (2k,1c) renal hypertensive rats. after clipping the left renal artery, animals were assigned to either a normal diet group (control group) or a sesamin-containing (1% (w/w)) diet group (sesamin group). the sham-operated rats (sham group) were fed a normal diet and tap water. the systolic blood pressure of the control group increased progressively in comparison with the sham group. this 2k ... | 1995 | 8845824 |
| estradiol benzoate potentiates neuroactive steroids' effects on pain sensitivity. | progesterone (p), its metabolites, and other neuroactive steroids alter pain thresholds consistent with their efficacies at modulating gamma-aminobutyric acid (gabaa) receptor complexes. we investigated whether estradiol benzoate (eb) potentiates low dosages of neuroactive steroids' effects on pain. subcutaneous eb (10 micrograms) or sesame oil vehicle was administered to ovariectomized long-evans rats (n = 40) 48 h before intracerebroventricular (icv) infusion of a neuroactive steroid (0.0, 0.1 ... | 1996 | 8848456 |
| adolescent anabolic steroid use and aggressive behavior in golden hamsters. | in the present study, the ability of high-dose androgens, namely aas, administered during adolescence to facilitate aggressive behavior in experimental animals was examined. data from these studies show clearly that exposure to high doses of multiple aas during adolescent development can predispose animals to intense bouts of aggressive behavior during young adulthood. specifically, young adult hamsters treated with high doses of aas throughout adolescence were more likely to attack and bite int ... | 1996 | 8853620 |
| maintenance of decidual cell reaction by androgens in the mouse. | in the mouse, estrogen and progesterone are required to prime the uterus for decidual cell reaction (dcr) in response to an intraluminal stimulus and, once dcr is induced, progesterone is required to maintain dcr. however, some evidence indicates that certain nonprogestational steroid hormones may also be involved in regulating dcr. the present study determined whether androgen plays any role in dcr. adult cd1 mice were ovariectomized and treated with a regimen of estradiol and progesterone to p ... | 1996 | 8862767 |
| behavioral effects of 3 alpha-androstanediol. i: modulation of sexual receptivity and promotion of gaba-stimulated chloride flux. | pregnane neurosteroids may initiate sexual receptivity not only via actions at intracellular receptors, but by affecting gamma-aminobutyric acid (gaba) receptor complexes (gbrs). to investigate whether gbr-mediated actions of an androgenic neurosteroid 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-androstanediol; 3 alpha-diol) may influence the expression of sexual behavior, ovariectomized (ovx) rats received daily injections of 3 alpha-diol (0.6, 3.0, 6.0 and 7.5 mg/kg) or vehicle (10% (v/v ... | 1996 | 8883822 |
| inhibition by memantine of the development of persistent oral dyskinesias induced by long-term haloperidol treatment of rats. | 1. tardive dyskinesia (td) is a serious side-effect of long-term treatment with neuroleptics. to investigate if neuroleptic-induced excessive stimulation of striatal glutamate receptors may underlie td development, the effect of the nmda antagonist, memantine (1-amino-3,5-dimethyladamantane), was studied in a rat model of td. 2. in an acute experiment, six groups of rats were treated daily for 1 week with either vehicle or memantine 20 or 40 mg kg-1 day-1, and on the seventh day they received on ... | 1996 | 8904651 |
| follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. | the mechanism of 4-vinylcyclohexene diepoxide (vcd)-induced oocyte destruction in small preantral follicles of rats and mice has not been elucidated. this study examined the effects of daily dosing of female rats with vcd on protein synthesis and follicle viability. an investigation of granulosa cells as a target for vcd was also made. small preantral follicles (25 to 100 microns) isolated from untreated immature rats (day 28) as well as from rats injected daily for 10 d with vcd (0.57 mmol/kg, ... | 1996 | 8919611 |
| effect of sesame oil on serum and liver lipid profiles in the rat. | in our previous study (satchithanandam, s., reicks, m., calvert, r.j., cassidy, m.m. and kritchevsky, d. (1993) j. nutr. 123, 1852-1858), we found that the absorption of lymphatic cholesterol by rats fed diets containing 24% sesame oil was about 50% less than that by rats fed the control diet containing no sesame oil. the effect of sesame oil on serum cholesterol levels was not determined at that time. in the present study, three groups of male wistar rats (75-100 g) were fed a control diet or a ... | 1996 | 8979168 |
| differential induction of fos in the female rat brain following different amounts of vaginocervical stimulation: modulation by steroid hormones. | vaginocervical stimulation (vcs), produced either by copulation with intromission or by manual stimulation of vagina and cervix with a glass rod, induces neuroendocrine and behavioral responses that are critical for female reproduction in many species. we and others have shown that fos mrna and protein are induced within different estrogen-concentrating and -non-concentrating regions of the female rat brain following copulation with intromission and manual vcs. in the present study, we investiga ... | 1996 | 9001738 |
| chronic treatment with diazepam or abecarnil differently affects the expression of gabaa receptor subunit mrnas in the rat cortex. | diazepam and abecarnil produce their overt effects by interaction with the gabaa receptor. chronic treatment with abecarnil, however, does not induce diazepam-like tolerance. this study investigates the effects of chronic diazepam and abecarnil treatment on expression of gabaa receptor alpha 1-6 beta 1-3 and gamma 1-3 subunit isoform mrnas in rat cortex. male sprague-dawley rats were injected subcutaneously once daily for 7 or 14 days with 15 mg/kg diazepam or 6 mg/kg abecarnil in sesame-oil veh ... | 1996 | 9014161 |
| whey mineral supplementation and arterial tone in mineralocorticoid-nacl hypertension. | the aim was to study the effects of supplementation of rat chow diet with whey mineral concentrate (whey), a diet rich in milk minerals, on arterial responses in vitro in mineralocorticoid-nacl hypertension. | 1996 | 9015414 |
| effect of adrenalectomy and corticosterone substitution on glucose and glycogen metabolism in rat brain. | in non-nervous tissues, glucocorticoids (gcs) counteract the effects of insulin and stimulate gluconeogenesis. the present study was designed to investigate whether or not adrenalectomy (adx) and glucocorticoid substitution influence the pathway of both glucose and glycogen metabolism in cerebral parietotemporal cortex and hippocampus, and if so how. the activities of respective key enzymes, such as hexokinase (hk), phosphofructokinase (pfk), pyruvate kinase (pk), glucose-6-phosphatase (g6pase) ... | 1996 | 9026380 |
| buthionine sulfoximine (bso) and n-(3,5-dichlorophenyl)succinimide nephrotoxicity: temporal aspects of bso administration and bso effects on renal transport systems. | the agricultural fungicide, n-(3,5-dichlorophenyl)succinimide (ndps) induces acute polyuric renal failure which is attenuated by pretreatment with the glutathione depletors, diethyl maleate or buthionine sulfoximine (bso). in the present study, the temporal aspects of bso attenuation of ndps nephrotoxicity were investigated. in addition, the ability of bso to alter the renal accumulation of selected organic ions was examined as a possible mechanism for bso's ability to attenuate ndps nephrotoxic ... | 1997 | 9057900 |
| lack of gonadotropin-positive feedback in the male rat is associated with lack of estrogen-induced synaptic plasticity in the arcuate nucleus. | we have demonstrated that estrogen induces synaptic reorganization in the hypothalamic arcuate nucleus of female rats during the ovarian cycle and proposed that estrogen-induced synaptic retraction plays a role in the disinhibition of gonadotropin secretion that occurs during the afternoon of proestrus. this so-called positive feedback of gonadotropins is developmentally determined. it is present in female rats and absent in males. to confirm the role of the estrogen-induced synaptic retraction ... | 1997 | 9067991 |
| temporal- and hormone-dependent changes in uterine sensitization for the decidual cell reaction and decidualization in vitro of rat endometrial stromal cells. | the ability of endometrial stromal cells from nonsensitized rat uteri to undergo decidualization in vitro was investigated. cells were obtained by enzymatic dispersion from uteri of ovariectomized, steroid-treated rats at the equivalent of day 4, 5 or 6 of pseudopregnancy, or on day 5 from rats treated with 0, 0.3 or 1.0 microgram oestradiol (low, intermediate or high doses of oestradiol, respectively) on day 4, and cultured for 24, 48 or 72 h. decidualization in vivo, as assessed by uterine mas ... | 1997 | 9068424 |
| 7-sulfooxymethylbenz[a]anthracene is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene. | the hypothesis was tested that 7-sulfooxymethylbenz[a]anthracene (7-sba) is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene. in conformity with this hypothesis, 7-sba was more carcinogenic than 7-hba in inducing sarcomas at the site of repeated subcutaneous injection. these metabolites were individually administered to female sprague-dawley rats, beginning at 30 days of age, in 0.2 mumol doses given three times each week for 20 doses. one year after the first ... | 1997 | 9070878 |
| sesame lignans modulate cholesterol metabolism in the stroke-prone spontaneously hypertensive rat. | 1. effects of sesamin and episesamin (an epimer of sesamin) on lipid metabolism, in particular cholesterol metabolism, were examined in normocholesterolaemic and hypercholesterolaemic stroke-prone spontaneously hypertensive rats (shrsp). 2. in normocholesterolaemic shrsp fed a regular diet, both sesamin and episesamin significantly increased the concentration of serum total cholesterol, which was due to an increase of high density lipoprotein (hdl) subfraction rich in apoe (apoe-hdl). in additio ... | 1995 | 9072406 |
| dietary and hypothalamic changes in delta 4-androstenedione-treated zucker rats. | dehydroepiandrosterone (dhea) has been shown to alter hypothalamic monoamines and reduce energy intake (ei) in zucker rats (zrs). we hypothesized that a metabolite of dhea, delta 4-androstenedione (delta 4), may mediate these effects. male lean and obese zrs (lzr, ozr) were fed control chow (cc) for 7 days, during which basal ei was recorded, various concentrations of delta 4 for 7 days, during which 0.6 and 0.3% delta 4 reduced ei significantly, and cc for 7 days, which resulted in a return of ... | 1997 | 9108584 |
| enhanced metabolism of arginine and glutamine in enterocytes of cortisol-treated pigs. | this study was designed to determine whether cortisol plays a role in arginine and glutamine metabolism in enterocytes and, more specifically, whether cortisol regulates metabolic changes in these cells during weaning. twenty-eight 21-day-old suckling pigs were randomly assigned to one of four groups (7 animals in each) and received intramuscular injections of vehicle solution (sesame oil) (control group), hydrocortisone 21-acetate (hyd) (25 mg/kg body wt), ru-486 (10 mg/kg body wt) (a potent bl ... | 1997 | 9124567 |
| the effect of streptozotocin-induced diabetes on dopamine2, serotonin1a and serotonin2a receptors in the rat brain. | the effect of streptozotocin (stz)-induced diabetes and a combination of chronic treatment with haloperidol (hpd) on dopamine (da)d2, serotonin (5-ht) 5-ht1a and 5-ht2a receptors was investigated in rat brain. rats were randomly assigned to one of four groups: vehicle-vehicle, stz-vehicle, vehicle-hpd, and stz-hpd groups. four weeks after single administration of stz (65 mg/kg iv) or vehicle (citrate buffer), rats received depot hpd (4 mg/kg im) or vehicle (sesame oil) once a week for 4 weeks. s ... | 1997 | 9138434 |
| arteether: risks of two-week administration in macaca mulatta. | male rhesus monkeys (macaca mulatta) were administered daily doses of the antimalarial drug arteether. the 14-day treated group received either 24 mg/kg/day, 16 mg/kg/day, or 8 mg/kg/day. the seven-day treatment group received either 24 mg/kg/day or 8 mg/kg/day. all control cases in each group received the sesame oil vehicle alone. neurologic signs were absent for animals in the seven and 14-day treatment groups except for one monkey which showed diffuse piloerection on day 14, and another monke ... | 1997 | 9158046 |
| effects of toremifene on neonatal rat uterine growth and differentiation. | in the developing rodent uterus, the estrogen agonist activity of triphenylethylene antiestrogens such as tamoxifen alters uterine luminal epithelium morphology and inhibits uterine gland genesis. we examined uterine growth and differentiation in female offspring from date-mated sprague-dawley rats given the structurally related antiestrogen, toremifene, by s.c. injection in 10 microl of sesame oil on postnatal days (pnd) 1-5, 10-14, or 20-24. toremifene given on pnd 10-14, a period of rapid ute ... | 1997 | 9160724 |
| sex differences in the effects of gonadectomy and acute swim stress on gabaa receptor binding in mouse forebrain membranes. | gonadectomy of male mice resulted in a significant increase in gabaa receptor binding in forebrain membranes at gaba concentrations of 100-1000 nm, whereas gonadectomy of female mice resulted in no significant change in such binding. acute swim stress (3 min swim at 32 degrees c) in gonadectomised female mice resulted in a significant increase in gabaa receptor binding in forebrain membranes at gaba concentrations of 400-1000 nm and in the plasma levels of corticosterone, whereas this stress pro ... | 1997 | 9185158 |
| the heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for alzheimer disease. | we have shown that heat shock induces rapid dephosphorylation of tau in both female and male rats followed by hyperphosphorylation only in female rats. to investigate the role of gonadal hormones, rats were ovariectomized (ovx), orchiectomized (orx), or sham-gonadectomized and received replacement therapy with estradiol benzoate (eb), testosterone propionate (tp), or sesame oil (so) vehicle for 2-3 weeks, respectively. at 0, 3, 6, and 12 hr after heat shock, immunoblot analysis of sds cerebral e ... | 1997 | 9192613 |
| sesamol as an inhibitor of growth and lipid metabolism in mucor circinelloides via its action on malic enzyme. | sesamol, a nonoil component of sesame seed oil, inhibited growth, fatty acid synthesis, and desaturation by mucor circinelloides in vivo. although sesamol also inhibited the growth of other fungi and yeasts, its effect on the lipid metabolism of m. circinelloides was exceptional. an enzymological study demonstrated that sesamol affected lipid synthesis primarily by the inhibition of malic enzyme activity, thereby limiting the nadph supply for fatty acid synthesis and desaturation. sesamol itself ... | 1997 | 9208389 |
| diet and stomach cancer in korea. | stomach cancer is the most prevalent malignant neoplasm in korea. as of 1991-1992 in seoul, the cumulative rates reported for the age span 0-74 were 7.6% in males and 3.1% in females. a recent case-control study reported that several food items and cooking methods are associated with increased or decreased risk of stomach cancer among koreans. an increased risk of stomach cancer was noted among people who frequently consume broiled meats and fishes, salted side dishes (salted/fermented fish prod ... | 1997 | 9209012 |
| the effects of type i and type ii corticosteroid receptor agonists on exploratory behavior and spatial memory in the y-maze. | we investigated the effects of two adrenal steroid agonists on adrenalectomized (adx) rats' performance on the y-maze. the y-maze was chosen because memory can be assessed quickly and because it is sensitive to various parameters of exploratory behavior and spatial memory performance. four days after surgery, adx rats were injected with aldosterone (aldo, a selective type i receptor agonist), ru362 (a selective type ii receptor agonist) or sesame vehicle at three different time points (120 min p ... | 1997 | 9219865 |
| chronic zolpidem treatment alters gaba(a) receptor mrna levels in the rat cortex. | the effect of chronic zolpidem treatment on the steady-state levels of gamma-aminobutyric acida alpha1-6, beta1-3 and gamma1-3 subunit mrnas in rat cortex has been investigated. male sprague-dawley rats were injected once daily, for 7 or 14 days, with 15 mg/kg of zolpidem in sesame oil vehicle. the levels of the alpha4 and beta1 subunit mrnas were significantly increased after 7 days of treatment and the level of alpha1 subunit mrna was significantly decreased after 14 days of treatment, as dete ... | 1997 | 9226404 |
| discrepancy between in vitro and in vivo antifungal activity of albendazole. | albendazole has in vitro activity against cryptococcus neoformans and reduced in vitro activity for albendazole when compared with candida albicans. the major metabolite of albendazole, albendazole sulphoxide showed no in vitro activity against isolates of either fungus. immunocompetent mice infected intravenously (i.v.) with c. albicans were treated with albendazole doses of 20-600 mg kg-1 per day in noble agar or sesame oil for per oral (po) administration, or 80 mg kg-1 per day in dmso for in ... | 1997 | 9229330 |
| studies on the mechanism of absorption of depot neuroleptics: fluphenazine decanoate in sesame oil. | the purpose of the present study was to investigate the pharmacokinetic characteristics of fluphenazine (flu) and its decanoate (flu-d) after intravenous and intramuscular administration to dogs. | 1997 | 9279892 |
| utilisation of u-14c-lysine by young turkeys. | 1. u-14c-lysine was administered by tube into the crop to turkey poults fed on assay diets (maize + sesame + maize gluten meal) containing varying concentrations of lysine, and partition of the label into body components, carbon dioxide, and excreta was measured. 2. deposition of 14c label into breast and heart muscles responded positively to dietary lysine concentration. there was no apparent relationship between dietary lysine intake and deposition of label into carbon dioxide or excreta. 3. e ... | 1997 | 9280354 |
| production of bcg alginate-pll microcapsules by emulsification/internal gelation. | a biocompatible emulsification method for microencapsulation of live cells and enzymes within a calcium alginate matrix applied to bacillus calmette-guérin (bcg) has been developed. small-diameter alginate beads (microcapsules) were formed via internal gelation of an alginate solution emulsified within vegetable oil. five different oils (sesame, sweet almond, perhydrosqualene, camomile and jojoba) were used. the rheological analysis of the oils showed a newtonian behaviour, with viscosities = 30 ... | 1997 | 9292438 |
| effects of prenatal testosterone on sexual behavior, reproductive morphology and lh secretion in the female rat. | sexual differentiation of many brain structures and functions is dependent on levels of testosterone (t) or its metabolites during certain 'sensitive' developmental periods. if t is present during these perinatal periods, masculinization and defeminization of sexual behavior occur; also, reproductive physiology, and central nervous system morphology and function are altered. the purpose of the present study was to characterize the influence of t at specific prenatal developmental intervals on of ... | 1997 | 9323463 |
| effects of sodium sulfate on acute n-(3,5-dichlorophenyl)succinimide (ndps) nephrotoxicity in the fischer 344 rat. | the agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) induces acute polyuric renal failure in rats. results of previous studies have suggested that ndps may induce nephrotoxicity via conjugates of ndps metabolites. thus, the purpose of this study was to examine if administered sodium sulfate could alter ndps nephrotoxicity. male fischer 344 rats (four rats per group) were administered a single intraperitoneal (i.p.) injection of sodium sulfate (0.035, 0.07, 0.35 or 3.5 mmol/kg) or ... | 1997 | 9347919 |
| the effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats. | pth treatment can result in dramatic increases in cancellous bone volume in normal and osteopenic rats. however, this potentially beneficial response is only observed after pulsatile treatment; continuous infusion of pth leads to hypercalcemia and bone abnormalities. the purpose of these studies was to determine the optimal duration of the pth pulses. a preliminary study revealed that human pth-(1-34) (hpth) is cleared from circulation within 6 h after sc administration of an anabolic dose of th ... | 1997 | 9348185 |
| cloning, expression and isoform classification of a minor oleosin in sesame oil bodies. | the oil bodies of plant seeds contain a triacylglycerol matrix surrounded by a monolayer of phospholipids embedded with alkaline proteins termed oleosins. two distinct oleosins are present in the oil bodies of diverse angiosperms, and classified as high and low mr isoforms according to their relative molecular masses in each species. in sesame oil bodies, besides the two ubiquitous oleosin isoforms (17 and 15 kda), an additional minor oleosin (15.5 kda) was revealed on tricine sds-page. a full-l ... | 1997 | 9399587 |
| decreased superovulation in adult mice following neonatal exposures to technical methoxychlor. | to examine the effects of technical methoxychlor (mxc) on superovulation, neonatal mice received intraperitoneal (i.p.) injections of either sesame oil, 10 micrograms of estradiol 17 beta, or 0.1, 0.5, or 1 mg of technical mxc. at 2 and 4 months, half of the mice received a superovulatory regimen of 10 iu pregnant mare's serum gonadotropin followed by 10 iu human chorionic gonadotropin. the mice were sacrificed 15 to 20 h later, the number of ovulated oocytes were counted, and the ovaries were r ... | 1997 | 9407591 |