Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| effects of high fat diet on fecal contents of bile acids in rats. | the effects of dietary oils and fats used in japan on the fecal contents of bile acids in rats were studied. f344/du crj female rats (8 weeks old) were fed on diet containing 20% corn oil, rape seed oil, sesame oil, soybean oil, lard, or tallow as high oil or fat diets or on 0.2% linoleic acid diet as a low fatty acid diet for 4 weeks, and then their feces were collected. bile acids in the feces were partially purified and analyzed by high-performance liquid chromatography. analyses showed that ... | 1987 | 3121554 |
| effect of testosterone on growth hormone secretion in female rats during a continuous infusion of growth hormone releasing factor. | the effect of testosterone on growth hormone (gh) secretory pattern during a 6-hour continuous infusion of human gh-releasing factor (grf) (1-44) nh2 was observed in unrestrained adult female wistar rats. rats had been ovariectomized or sham operated 6 weeks previously. three weeks after the ovariectomy, the rats received sesame oil or testosterone propionate at a dose of 1 or 2 mg s.c. daily for 21 days. all rats were provided with two indwelling cannulae: one in the right atrium for undisturbe ... | 1988 | 3125487 |
| in vivo utilization of lysine and arginine in young chicks fed monensin. | three chick growth assays were conducted to investigate the effects of monensin on lysine and arginine utilization in crossbred chicks (new hampshire x columbian). chicks were fed either a low lysine corn-sesame meal diet containing graded increments of crystalline lysine.hcl (assay 1) or an arginine-deficient casein-dextrose diet (assay 2) supplemented with graded levels of l-arginine.hcl in the presence or absence of supplemental monensin (121 mg/kg). based upon analysis by slope-ratio methodo ... | 1988 | 3132706 |
| bioavailability of lysine in l-lysine.hcl. | true digestibility of lysine (lys) in crystalline l-lys.hcl and casein determined in cecectomized adult roosters was not significantly different from 100%. subsequent 9-d growth assays were conducted to determine the bioavailability of lys in casein, in l-lys.hcl, and in a mixture of crystalline amino acids simulating casein's amino acid profile. based on slope-ratio methodology, lys bioavailability relative to casein was estimated to be 101.4 and 99.9% in l-lys.hcl and in the casein-simulated a ... | 1988 | 3143708 |
| seedborne fungi of sesame (sesamum indicum l) in sierra leone and their potential aflatoxin/mycotoxin production. | sesame seeds (sesamum indicum l) from four different geographic locations in sierra leone were sampled for their mycoflora. three toxigenic aspergillus species: a. flavus link ex fries, a. ochraceus wilhelm, and a. tamarii kita were common to all samples. penicillium citrinum thom and two fusarium sp. were found in samples from two localities. the mycotoxins aflatoxin b1 and g1, ochratoxin a and b, and citrinin were positively identified. | 1988 | 3146700 |
| [use of sunflower (heliantus annus, l.) in human foods. ii. enrichment of sunflower protein concentrate with fish and sesame flour]. | the first part of this study revealed that a sunflower meal submitted to thermic treatment resulted in a protein of better quality when supplemented with lysine, while the meal not subjected to thermic treatment, supplemented with methionine, did not increase its nutritional value. these data indicated, therefore, that the limiting amino acid in sunflower meal is lysine, and not methionine. based on these findings, and in order to confirm previous results, fish flour (high in lysine) and sesame ... | 1988 | 3154070 |
| [sesame seed (sesamum indicum, l.). i. methods for preparing an edible white flour]. | methods for processing of the sesame seed were tested in order to obtain an edible meal. the nutritive value of this meal was evaluated by chemical and biological analyses. according to the results obtained, it was concluded that the best method is to submit the seeds to a maceration process and to a vapor treatment. the sesame flour protein is of reasonable quality, rich in sulfur amino acids. although is has a low lysine level, it can be utilized for complementing the amino acid pattern of oth ... | 1988 | 3154071 |
| [sesame seed (sesamum indicum, l.). ii. use of sesame flour in protein mixtures]. | the results obtained in the first part of this study demonstrated that the sesame flour protein is of reasonable quality and can be utilized, although it has a low lysine content and is rich in sulfur amino acids. based on the initial data, the sesame flour was supplemented with other meals: "carioca" beans, pigeon pea, and soybean. nine diets were prepared and the best combination was that of 50% sesame flour protein and 50% pigeon pea, the per of which was 2.28. breads were made with these sys ... | 1988 | 3154072 |
| influence of spironolactone on urinary prostaglandin e2 and kinin excretion in rats. | spironolactone was administered to spontaneously hypertensive rats (shrs) in order to examine the urinary excretions of prostaglandin e2 (pge2) and kinin. thirteen shrs were divided into 2 groups: 0.1 ml of sesame oil was administered to one group (the spironolactone-lactone-untreated group, n = 6) and 20 mg of spironolactone in 0.1 ml of sesame oil was administered to the other group (the spironolactone-treated group, n = 7) by the subcutaneous route for 10 days in succession. determinations we ... | 1988 | 3163804 |
| the role of anabolic steroids on baseline and stress heart rate in cynomolgus monkeys. | this investigation examined the role of anabolic steroids on baseline heart rate (hr) and hr responses to the threat of capture in macaca fascicularis. ten cynomolgus monkeys were randomly assigned either to a steroid or to a sham control group. steroid-treated animals were given testosterone injections biweekly for 10 weeks, whereas sham controls received injections of sesame oil on an identical schedule. pretreatment and posttreatment hrs were evaluated to establish both baseline and acute-str ... | 1988 | 3168976 |
| effect of exogenous progesterone on prostaglandin f2 alpha release and the interestrous interval in the bovine. | the present study was developed to determine if administration of progesterone, early in the estrous cycle of the cow, stimulated an advanced pulsatile release of pgf2 alpha from the uterine endometrium resulting in a decreased interestrous interval. twenty-three cyclic beef cows were randomly assigned to receive either sesame oil or progesterone (100 mg) on day 1, 2, 3 and 4 of the estrous cycle. peripheral plasma concentrations of progesterone and the metabolite of prostaglandin f2 alpha, 15-k ... | 1988 | 3175025 |
| uterine decidualization in hypophysectomized-ovariectomized rats: effects of pituitary hormones. | decidualization of the endometrial stroma occurs in rats in response to implanting blastocysts or after the application of an appropriately timed artificial stimulus. it is well established that decidualization is regulated by estrogens and progesterone (p). the present study investigated the role of pituitary hormones in this response. decidualization produced by the bilateral intrauterine injection of 100 microliter sesame oil was compared in ovariectomized (ovx) and hypophysectomized (hypox)- ... | 1988 | 3179384 |
| enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis. | the existence of a rare syndrome of "enflurane hepatitis" similar to that described for halothane and of a cross-sensitization between halothane and enflurane has been controversial, largely due to equivocal clinical case reports and a lack of a plausible molecular mechanism for the hepatotoxicity. the present study suggests a possible hypersensitivity basis for enflurane hepatitis and the apparent cross-sensitization between halothane and enflurane involving covalently bound liver microsomal ad ... | 1988 | 3195754 |
| evidence for maternal regulation of early conceptus growth and development in beef cattle. | fifty-one cyclic beef cows were mated with fertile bulls. at 36 h after the start of oestrus, cows were assigned to receive sesame oil (controls) or progesterone (100 mg) on days 1, 2, 3 and 4 of pregnancy. peripheral plasma concentration of progesterone was measured until slaughter on days 5 or 14. cows were randomly assigned to be slaughtered on days 5 or 14 or remain intact and palpated per rectum on day 40 to verify pregnancy. uteri on days 5 and 14 were flushed for recovery of luminal prote ... | 1988 | 3199361 |
| nephrotoxicity of n-(3,5-dichlorophenyl)succinimide metabolites in vivo and in vitro. | the experimental fungicide n-(3,5-dichlorophenyl)succinimide (ndps) has been shown to produce selective nephrotoxicity at least in part through the actions of one or more metabolites. the purpose of this study was to (1) determine the nephrotoxic potential of three known ndps metabolites; n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs), n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (ndhsa), and n-(3,5-dichlorophenyl)malonamic acid (dma) and (2) examine the role of renal biotransformation in ... | 1988 | 3206523 |
| activation of antioxidant activity in natural medicinal products by heating, brewing and lipophilization. a new drug delivery system. | on the basis of the authors' previous hypothesis (1) that treatment of natural plant products with heating and gastric juice results in liberation of low molecular weight compounds with antioxidant activity that exist in the native products as repeating subunits of high molecular weight polymers, they have developed specially treated natural health or medicinal products in which several identifiable low molecular weight compounds with antioxidant activity are liberated and activated. the princip ... | 1988 | 3219997 |
| the effects of ovarian hormones on glucose and fatty acid oxidation during exercise in female ovariectomized rats. | the effects of ovarian hormones on glucose and fatty acid oxidation during exercise were investigated in adult female ovariectomized rats. rats subdivided into 3 groups received intraperitoneal injections of hormones or sesame oil for 8 days. estrogen (e) treated rats received 17-beta estradiol in daily doses of 2 micrograms. estrogen and progesterone treated rats (ep) received 17-beta estradiol in daily doses of 2 micrograms and 2 mg, respectively. control rats (s) received sesame oil alone. af ... | 1988 | 3220443 |
| chlamydial salpingitis in female guinea pigs receiving oral contraceptives. | female guinea pigs were given daily doses of a combination of oral contraceptive (oc) agents, consisting of mestranol and norethynodrel suspended in sesame oil or distilled h2o, and were infected in the genital tract with the chlamydial agent of guinea pig inclusion conjunctivitis (gpic). counts of chlamydial inclusions in cells of vaginal smears collected during infection, showed prolongation and enhancement of infection in oc-treated animals as compared with controls. appearance of igg and iga ... | 1988 | 3227473 |
| ocular absorption and disposition of phenylephrine and phenylephrine oxazolidine. | the ocular bioavailability of phenylephrine oxazolidine (po), a prodrug intended for rapid corneal penetration, was micronized and suspended in sesame oil (1 and 10 per cent) and compared in bioavailability to phenylephrine hc1 (pe) dissolved (10 per cent) in a buffered (ph 5.75), viscous (30 centipoise) vehicle. cornea and aqueous humor of new zealand rabbits were measured over time following 10 microliter instillation to the eye. based upon auc measurements, corneal and aqueous humor levels we ... | 1988 | 3228574 |
| gender-specific and gonadectomy-specific effects upon swim analgesia: role of steroid replacement therapy. | both gender-specific and gonadectomy-specific effects have been observed for the analgesic responses following continuous and intermittent cold-water swims (ccws and icws respectively): female rats display significantly less analgesia than males, and gonadectomized rats display significantly less analgesia than sham-operated controls. the present study evaluated the effects of steroid replacement therapy with testosterone propionate (tp: 2 mg/kg, sc) upon ccws and icws analgesia on the tail-flic ... | 1988 | 3237832 |
| partial reversal of the iminodipropionitrile-induced hyperkinetic syndrome in rats by alpha-tocopherol (vitamin e). | rats were treated with the neurotoxin iminodipropionitrile (idpn), which causes an irreversible movement disorder accompanied by axonal damage similar to that seen in vitamin e deficiency. animals that received 2 g/kg vitamin e concurrently with 100 mg/kg idpn for 10 days demonstrated a significantly reduced severity of idpn-induced dyskinesia (as measured by vertical head movements) compared to animals that received idpn alone. when animals were treated with 100 mg/kg idpn for 10 days and then ... | 1988 | 3251508 |
| [obtention and evaluation of a precooked flour of auyama (cucurbita maxima) and rice, enriched with oleaginous proteins and/or skim milk]. | the purpose of the present study was the production of a precooked blend made of pumpkin squash and rice flour (prb), processed with drum dyer. the blend was supplemented with different protein sources: soy, sesame and deffated milk. the following formulations were obtained: i) prb + 10.5% deffated soy flour; ii) prb + 15% deffated milk; iii) prb + 5% deffated sesame flour + 10% deffated milk; iv) prb + 5% deffated soy flour + 10% deffated sesame flour, and v) prb + 9.5% deffated soy flour + 9.5 ... | 1988 | 3256284 |
| [influence of spironolactone on urinary prostaglandin e2 and kinin excretions in spontaneously hypertensive rats]. | spironolactone was administered to spontaneously hypertensive rats (shrs) in order to examine the urinary excretions of prostaglandin e2 (pge2) and kinin. thirteen shrs were divided into 2 groups, and 0.1 ml of sesame oil was administered to one of 2 groups (spironolactone-untreated group) (n = 6) and 20 mg of spironolactone in 0.1 ml of sesame oil was administered to the other group (spironolactone-treated group) (n = 7) by the subcutaneous route for 10 days in succession, followed by the deter ... | 1988 | 3288509 |
| effects of sesame and cod liver oils on prostacyclin synthesis by the rat thoracic aorta. | the influence of sesame and cod liver oils (0.5 and 1 g/kg/day s.c. for 2 weeks) on arterial pgi2 synthesis in the rat was investigated using a rat platelet antiaggregatory bioassay and hplc methods. smaller doses did not affect pgi2 synthesis. however, sesame oil at a dose of 1 g/kg/day significantly stimulated pgi2 synthesis, whereas cod liver oil at the same dose significantly decreased the synthesis. incubation of control tissues in presence of exogenous arachidonic acid (33 microm) signific ... | 1988 | 3293541 |
| neuropeptide y stimulates the release of luteinizing hormone-releasing hormone from medial basal hypothalamus in vitro: modulation by ovarian hormones. | these studies investigated the effects of neuropeptide y (npy) on in vitro release of luteinizing hormone-releasing hormone (lhrh) from the medial basal hypothalmus (mbh) and tested whether ovarian steroids modulate the lhrh response to npy. ovariectomized rats were implanted with 20-mm-long silastic capsules containing a low concentration of estradiol (e2) (150 micrograms/ml oil), a high concentration of e2 (250 micrograms/ml oil), or sesame oil vehicle. additional animals received high-dose e2 ... | 1987 | 3306435 |
| effects of castration, exogenous testosterone and estrogen on endotoxin response in male rats. | using an experimental model of continuous endotoxin infusion, the effects of castration, testosterone and estrogen substitution on disseminated intravascular coagulation in male rats were investigated. male rats which are not pretreated react in the same way to an endotoxin infusion as female animals, with an increase in free plasma hemoglobin, decrease of fibrinogen level, decrease of hematocrit and platelets and glomerular fibrin depositions. different experimental groups of testectomized rats ... | 1987 | 3308574 |
| soleus muscle atrophy in rats induced by cast immobilization: lack of effect by anabolic steroids. | to test the hypothesis that an anabolic steroid such as nandrolone decanoate (nd) will ameliorate or abolish disuse-mediated alterations resulting from five weeks of hindlimb immobilization, female sprague-dawley rats were divided into six groups: control, control + nd, shortened-immobilized, shortened-immobilized + nd, stretched-immobilized, and stretched-immobilized + nd. immobilization was accomplished by wrapping hindlimbs with plaster of paris. nandrolone decanoate in sesame oil was adminis ... | 1988 | 3341898 |
| effects of the antiestrogen ly 117018 on the modulation by ethinyl estradiol of the metabolism of [1-14c]oleic acid by perfused livers from normal and ovariectomized rats. | intact female sprague-dawley rats (195-249 g) and rats that had been ovariectomized (210-285 g) were injected subcutaneously for 14 days with ethinyl estradiol (15 micrograms/kg), the antiestrogen ly 117018 (500 micrograms/kg), both drugs simultaneously, or the vehicle (sesame oil) alone. livers were removed and perfused in vitro in a recycling system. the administration of ly 117018 alone did not affect the secretion of triacylglycerol by livers from normal rats but decreased the secretion of t ... | 1988 | 3342088 |
| effect of preparturient 17 beta-estradiol and relaxin on parturition and pup survival in the rat. | this study examined the requirement for 17 beta-estradiol (e) and relaxin (r) during the preparturient period (approximately the last 30 h of gestation) for normal parturition and pup survival in the rat. on the evening of day 21 of pregnancy, primiparous sprague-dawley rats were bilaterally ovariectomized or sham operated and fitted with silastic capsules containing one of four doses of e (6.0, 11.4, 45.6, or 68.4 micrograms in sesame oil) or sesame oil only. these rats were also injected sc wi ... | 1988 | 3359970 |
| pressor response to vasopressin and norepinephrine in doc-salt hypertensive and prehypertensive rats. | pressor responses to arginine-vasopressin (avp) and norepinephrine (ne) were studied in deoxycorticosterone (doc)-salt hypertensive and prehypertensive rats. doc-salt rats received weekly subcutaneous injection of doc acetate (30 mg/kg) and given 1% saline for drinking. salt and control rats received injections of sesame oil and given 1% saline or tap water, respectively. on the 5th day (prehypertensive stage) and at 6th week (hypertensive stage) after treatment had started, pressor responses we ... | 1988 | 3381222 |
| is high dosage testosterone an effective male contraceptive agent? | in male contraceptive trials, approximately half of normal men become azoospermic on high dosages of testosterone enanthate (te), whereas the other half of men become severely oligozoospermic. to determine whether sperm function is reduced in men with severe oligozoospermia induced by te, we studied sperm function in six normal men whose sperm counts were reduced to less than or equal to 5 x 10(6)/ml but not to azoospermia by high-dosage te administration for 5 to 6 months and five normal men wh ... | 1988 | 3396702 |
| stimulatory effects of prostaglandins upon endometrial alkaline phosphatase activity during the decidual cell reaction in the rat. | an early event of the decidual cell reaction in response to either natural or artificial deciduogenic stimuli is an increase in the activity of alkaline phosphatase in endometrial stromal cells. since it is known that prostaglandins have a stimulatory role in other events of the decidual cell reaction, this study addressed whether prostaglandins have any role in the increase in alkaline phosphatase activity. mature ovariectomized rats were sensitized for the decidual cell reaction with s.c. inje ... | 1988 | 3408781 |
| sensitivity of caudal arteries and the mesenteric vascular bed to norepinephrine in doca-salt hypertension. | this study was undertaken to determine what factors might contribute to arterial supersensitivity to norepinephrine associated with deoxycorticosterone acetate (doca)-salt hypertension in the rat. experimental groups of male rats were uninephrectomized and 1 week later began receiving twice weekly injections of doca (20 mg/kg s.c. in sesame oil) plus 1% nacl and 0.2% kcl in their drinking water. for each experimental group, a group of age-matched male rats underwent a sham operation and received ... | 1988 | 3410523 |
| intrauterine infusion of prostaglandins and decidualization in rats with uteri differentially sensitized for the decidual cell reaction. | experiments were performed to determine if the time- and hormone-dependencies of the decidual cell reaction in rats were maintained when prostaglandins (pgs) were infused into the uterine lumen from alzet osmotic mini-pumps. ovariectomized rats treated with estradiol and progesterone were used. in the infusion experiments, to reduce uterine pg production during decidualization, the rats received a single s.c. injection of 2 mg indomethacin before pump insertion, and the infusion vehicle containe ... | 1986 | 3456802 |
| 6-keto-prostaglandin e1 and the decidual cell reaction in rats. | although there is considerable evidence that prostaglandins (pgs) are involved in the decidual cell reaction in rats, which pgs are involved is uncertain. in the present study, we investigated the possibility that 6-keto-pge1 is involved. to determine its ability to induce decidualization, 6-keto-pge1 was infused unilaterally from alzet osmotic minipumps into the uterine lumen of ovariectomized rats treated with estrogen and progesterone to sensitize their uteri for the decidual cell reaction. t ... | 1986 | 3469690 |
| age-related decline in deciduogenic ability of the rat uterus. | to study age-related changes in uterine responsiveness to deciduogenic stimuli, virgin female rats of the t strain were ovariectomized at 4, 8, 10, or 12 mo of age and given daily s.c. injections of 3 mg progesterone for 7 days, commencing on the day after operation, and a single s.c. injection of 0.1 microgram estradiol-17 beta on the third day of the period. endometrial stimulation was effected by either endometrial traumatization or intraluminal instillation of sesame oil or prostaglandin e2 ... | 1987 | 3480007 |
| a prenatal source for defeminization of female rats is the maternal ovary. | sexual behavior in laboratory rats is influenced by a variety of factors in the perinatal environment. male rats are masculinized and defeminized in response to circulating testosterone perinatally. females undergo a process of feminization but in some cases are exposed to testosterone. previous work has shown that during prenatal development female rats normally undergo a partial masculinization and defeminization of sexual behavior as reflected by altered responsiveness to gonadal hormones in ... | 1987 | 3557331 |
| indomethacin and the epinephrine-induced breakdown of the blood-ocular barrier in rabbits. | using aqueous and vitreous fluorophotometry, the authors examined the blood-aqueous and blood-retinal barrier functions in three groups of pigmented rabbits. epinephrine (1.25%) was applied topically five times daily and indomethacin (0.5% sesame oil suspension) was applied topically three times daily to one eye of each of the animals in group 1; under the same regimen, epinephrine and indomethacin placebo were administered to one eye of each of the animals in group 2 and epinephrine placebo and ... | 1987 | 3557860 |
| an electron microscopic study of endrin induced alterations in unmyelinated fibers of mouse sciatic nerve. | this study examined the ultrastructural alterations in peripheral nerve of adult mouse following repeated sublethal exposures to endrin, a toxic chlorinated hydrocarbon which produces symptoms indicative of neuromuscular dysfunction. male mice were given 20 daily ip injections of endrin in sesame oil (0.2 ml) in doses that increased from 1.5 mg/kg on days 0-3, to 2.0 mg/kg on days 4-11, and to 4.0 mg/kg on days 12-19. controls were given the same intraperitoneal volume of sesame oil without endr ... | 1987 | 3561898 |
| the effect of probenecid on acute n-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in the fischer 344 rat. | n-(3,5-dichlorophenyl)succinimide (ndps), an experimental agricultural fungicide, has been shown to produce selective nephrotoxicity in rats. previous studies have shown that a metabolite(s) of extrarenal origin contributes to acute ndps-induced nephrotoxicity. the purpose of this study was to determine if the organic acid transport inhibitor probenecid could modify the renal toxicity produced by ndps administration. male fischer 344 rats were administered a single intraperitoneal (i.p.) injecti ... | 1987 | 3564052 |
| interference with the preovulatory luteinizing hormone surge and blockade of ovulation in immature pregnant mare's serum gonadotropin-primed rats with the anti-androgenic drug, hydroxyflutamide. | the involvement of androgens in the control of ovulation has been assessed by administration of the androgen antagonist, hydroxyflutamide, to prepubertal rats treated with pregnant mare's serum gonadotropin (pmsg) to induce first estrus and ovulation. without human chorionic gonadotropin (hcg) injection, only 46% of rats that received six 5-mg, s.c. injections of hydroxyflutamide at 12-h intervals, beginning an hour before s.c. injection of 4 iu pmsg on day-2 (day 0 = the day of proestrus), had ... | 1987 | 3593836 |
| retinol-induced stage synchronization in seminiferous tubules of the rat. | vitamin a deficiency (vad) in rats causes a progressive germ cell depletion and cessation of spermatogenesis resulting in seminiferous tubules which contain only sertoli cells, spermatogonia and a small number of preleptotene spermatocytes. spermatogenesis can be rapidly restored by the administration of retinol. our preliminary studies suggested a partial stage synchronization of many seminiferous tubules in vad male rats subsequently treated with retinol. to confirm this observation and to ach ... | 1987 | 3595524 |
| development of pig blastocysts in a uterine environment advanced by exogenous oestrogen. | routine embryo transfer techniques were used to establish recipient groups in which blastocysts were either asynchronous (blastocysts 24 h behind recipient uterus) or synchronous with their uterine environment. oestradiol valerate (5 mg) was administered on day 11 of the recipient's cycle to stimulate release of uterine secretion in the synchronous gilts (group se) and one group (ae) of asynchronous gilts. the gilts in the other asynchronous group (group ac) were injected with vehicle (sesame oi ... | 1987 | 3598949 |
| role of glutathione in acute n-(3,5-dichlorophenyl) succinimide-induced nephrotoxicity in sprague-dawley and fischer 344 rats. | n-(3,5-dichlorophenyl)succinimide (ndps), an experimental agricultural fungicide, has been shown to be a selective nephrotoxin in sprague-dawley and fischer 344 rats. previous studies have demonstrated that a toxic metabolite contributes to or is responsible for acute ndps-induced nephrotoxicity. the purpose of this study was to investigate the role of glutathione in ndps-induced renal effects. in 1 set of experiments, male sprague-dawley or fischer 344 rats received a single intraperitoneal (i. ... | 1987 | 3603574 |
| long-term alterations in histology and steroid receptor levels of the genital tract and mammary gland following neonatal exposure of female balb/ccrgl mice to various doses of diethylstilbestrol. | the relation of the dosage of diethylstilbestrol (des) administered neonatally to the incidence and severity of genital tract and mammary gland lesions and to the levels of sex hormone receptors was examined using a mouse model for human intrauterine des exposure. female balb/ccrgl mice received various doses of des (ranging from 5 x 10(-1)-10(-5) micrograms daily for the first 5 days of life) or the sesame oil vehicle alone. in the vagina, at all ages examined (1, 2, 6, and 12 months) cytosolic ... | 1987 | 3607758 |
| transplacental effects of diethylstilbestrol on mammary development and tumorigenesis in female aci rats. | female aci rats were exposed to diethylstilbestrol (des) transplacentally and followed to 10 months of age to assess the effect of the drug on mammary development and tumorigenesis. pregnant rats were given injections of vehicle (sesame oil) or des (total dose, 0.8 micrograms = low des or 8.0 micrograms = high des) on days 15 and 18 of gestation. pellets containing 2.5 mg des + 17.5 mg cholesterol (des pellet) or 20 mg cholesterol (chol pellet) were implanted s.c. into 12-week-old female offspri ... | 1987 | 3607779 |
| incorporation of amino acids into proteins of the hypothalamus of prepuberal female rats after estradiol treatment. | the arcuate nucleus-median eminence complex (am) undergoes major structural and functional changes during normal puberty or if exposed to a pulse of estradiol in the prepuberal period. those changes are expressed by increased synaptogenesis and by a drastic alteration in the feedback control of anterior pituitary gland hormone release. in this study we investigated the effects of estradiol benzoate (eb) on specific proteins in this hypothalamic area. prepuberal, 25-day-old female rats were admin ... | 1987 | 3614550 |
| structure-nephrotoxicity relationships for meta-substituted n-phenylsuccinimides. | the n-phenylsuccinimides are being evaluated as experimental agricultural fungicides. the purpose of this study was to examine the relationship between the electron withdrawing or electron donating properties of phenyl ring substituents on meta-substituted n-phenylsuccinimide (nps) derivatives and the nephrotoxic potential of the corresponding fungicides. male fischer 344 rats were administered a single intraperitoneal injection of a succinimide (0.4 or 1.0 mmol/kg) or vehicle (sesame oil, 2.5 m ... | 1987 | 3624773 |
| effect of microsomal enzyme activity modulation on n-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity. | n-(3,5-dichlorophenyl)succinimide (ndps) is an experimental agricultural fungicide which has been shown to be a selective nephrotoxin. the purpose of this study was to determine if a ndps metabolite contributes to acute ndps-induced nephrotoxicity. male sprague-dawley or fischer 344 rats were pretreated with a microsomal enzyme inducer [phenobarbital (pb) or 3-methylcholanthrene (3-mc)] or inhibitor [cobalt chloride (cocl2) or piperonyl butoxide (pibx)] followed by a single intraperitoneal injec ... | 1987 | 3629611 |
| acetone effects on n-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity. | acetone has been shown to potentiate the toxicity of many halogenated hydrocarbons. the purpose of this study was to determine if acetone could alter the acute nephrotoxicity produced by the experimental fungicide n-(3,5-dichlorophenyl)succinimide (ndps). male fischer 344 rats were administered acetone (1, 5 or 10 mmol/kg) or acetone vehicle (corn oil, 10 mg/kg) orally followed 16 h later by a single intraperitoneal injection of ndps (0.2 or 0.4 mmol/kg) or ndps vehicle (sesame oil, 2.5 ml/kg) a ... | 1987 | 3629627 |
| increasing the breaking strength of wounds exposed to preoperative irradiation using vitamin e supplementation. | this study investigated if the prophylactic administration of vitamin e, an antioxidant, normalizes the healing of wounds exposed to preoperative ionizing radiation. vitamin e was given intraperitoneally to three experimental groups of rats every other day at doses of 10, 20 or 40 international units (iu) until a total dose of 30, 60 or 120 iu respectively was administered. there were three control groups: non-irradiated control, irradiated, non-supplemented control and irradiated, sesame oil-su ... | 1987 | 3654105 |
| plasma and tissue levels of vitamin e in sheep following intramuscular administration in an oil carrier. | the bioavailability of two vitamin e preparations (d-alpha-tocopherol and dl-alpha-tocopherol) suspended in sesame oil solution and administered intramuscularly was evaluated in sheep. in sheep administered d-alpha-tocopherol and killed after 360 hr (group 2), there was a higher (p less than 0.01) bioavailability than for sheep injected with d-alpha-tocopherol (group 3) or dl-alpha-tocopherol (group 1) and killed 240 hr after dosing. in the 3 groups (5 sheep each) the highest blood plasma alpha- ... | 1987 | 3679697 |
| response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement. | light microscope autoradiography was utilized to investigate the separate proliferative activities of the basal and glandular cell types during androgen-mediated restoration of the ventral prostatic epithelium in castrated rats. our objective was to determine whether the proliferative population of the prostatic epithelium is restricted to the basal cell subtype under these experimental conditions. in the intact animal, substantial numbers of basal as well as glandular cells were found to be pro ... | 1987 | 3684783 |
| acute n-(3,4,5-trichlorophenyl)succinimide-induced nephrotoxicity in sprague-dawley and fischer-344 rats. | previous studies have shown that the experimental agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) produces acute nephrotoxicity via a reactive intermediate in sprague-dawley and fischer-344 rats. the purpose of this study was to examine if an arene oxide intermediate is a toxic metabolite contributing to ndps-induced nephropathy in rats. n-(3,4,5-trichlorophenyl)succinimide (ntps) was prepared to prevent arene oxide formation of ndps, and its nephrotoxic potential was determined ... | 1986 | 3726898 |
| pseudopregnancy and the decidual response in the obese zucker rat: a reexamination. | the ability to induce the pseudopregnant (psp) state and the decidual response (dr) in the obese zucker rat was reexamined. lean and obese rats were cervically stimulated on the evening of proestrus or morning of estrus. this procedure lengthened the period of vaginal diestrus in both groups to approximately 13 days. the percentage of obese rats (70.0%) that became psp was not significantly different from that of lean rats (72.2%). to test sensitivity to a decidual stimulus, sesame oil was injec ... | 1986 | 3730477 |
| angiographic, hemodynamic, and histologic evaluation of portal hypertension and periportal fibrosis induced in the dog by retrograde biliary injections of sesame oil. | periportal fibrosis and portal hypertension were induced by periodic retrograde biliary injections of sesame oil for two to three months in 12 cholecystectomized dogs equipped with thomas cannulas. stable portal hypertension between 18 and 24 cm of water occurred in four of 12 dogs (baseline: 10.4 +/- 0.5 cm of water); the remaining eight dogs required continuous biliary oil injections to maintain the portal pressure in that range. portosystemic venous collaterals were first seen three weeks aft ... | 1986 | 3733382 |
| effects of tamoxifen citrate and cycloheximide on estradiol induction of rat myometrial gap junctions. | longitudinal muscle of myometrial tissues from immature rats were examined by quantitative thin section electron microscopy for the presence of gap junctions after treatment with estradiol with and without tamoxifen, and cycloheximide for 1-6 days. gap junctions were present between myometrial cells on days 4, 5, and 6 after treatment with estradiol (500 micrograms/day). tamoxifen administered concomitantly with estradiol over the 6-day period completely prevented induction of the junctions. gap ... | 1986 | 3756620 |
| new injectable testosterone ester maintains serum testosterone of castrated monkeys in the normal range for four months. | two groups of four long-term orchidectomized cynomolgus monkeys, macaca fascicularis, weighing 2.8-4.6 kg received either a single intramuscular injection of 40 mg of a new testosterone ester, testosterone-trans-4-n-butylcyclohexyl-carboxylate (20 aet-1) in an aqueous suspension or 32.8 mg testosterone oenanthate dissolved in sesame oil. both preparations contained equal amounts of testosterone, namely 23.6 mg. testosterone oenenthate injections resulted in supraphysiological serum testosterone ... | 1986 | 3766044 |
| improving the ocular absorption of phenylephrine. | an oxazolidine prodrug of phenylephrine and the base form of phenylephrine were synthesized, suspended in sesame oil, and tested for mydriatic activity against phenylephrine hcl. the hcl salt was formulated as a viscous aqueous solution and as a sesame oil suspension. a dosing volume of 10 microliter was instilled into rabbit eyes and the pupillary diameter was measured over time. a 0.045 m prodrug suspension was judged equal in mydriatic activity to a 0.45 m viscous solution of phenylephrine hc ... | 1986 | 3779036 |
| effects of exercise and anabolic steroids on total and lipoprotein cholesterol concentrations in male and female rats. | forty male and 40 female rats were randomly assigned to 1 of 4 experimental groups. half of the animals of each gender were exercised by jumping (weighted by a vest with up to 70% body weight) to a height of 16 cm 20 times x d-1 (30 s between jumps) 5 d x wk-1 for 8 wk. half of the exercised animals and half of the sedentary animals were injected with the anabolic steroid durabolin (0.2 mg in 0.1 ml sesame seed oil) 6 d x wk-1 for the last 3 wk of the 8-wk exercise program. the other animals wer ... | 1986 | 3784880 |
| effect of oestrogen on pasteurella pneumotropica in rat vagina. | the effects of ovarian hormones on the vaginal population of pasteurella pneumotropica in rats were investigated. specified-pathogen-free adult female wistar-imamichi rats with a 4 day oestrous cycle were inoculated with p. pneumotropica in the vagina. cyclic changes in the vaginal population of p. pneumotropica were not observed in ovariectomized rats and the bacterial population was at a similar level to that at normal dioestrus. administration of oestrogen to ovariectomized rats caused an inc ... | 1986 | 3795854 |
| cyclic djungarian hamsters, phodopus campbelli, lack the progesterone surge normally associated with ovulation and behavioral receptivity. | serum levels of 17 beta-estradiol and progesterone were assayed at 4- to 5-h intervals across the estrous cycle in female djungarian hamsters, phodopus campbelli. the pattern of secretion for estradiol is similar to that described for the rat and the syrian hamster, rising slowly from a baseline of 54 +/- 2 pg/ml during the morning of estrus to a peak of 187 +/- 16 pg/ml in the early afternoon of proestrus, then falling rapidly back to baseline levels. the pattern of progesterone secretion is si ... | 1987 | 3830052 |
| comparison of the effects of sesame oil and oleic acid as suspension vehicles on gastrointestinal absorption of phenytoin in rats. | 1985 | 3830426 | |
| long-term responses of the mouse uterus to neonatal diethylstilbestrol treatment and to later sex hormone exposure. | the effects of ovariectomy at 1 month of age and continuous 17 beta-estradiol (e2) and/or progesterone (p) replacement on the uterus of balb/ccrgl mice neonatally treated with diethylstilbestrol [(des) cas: 56-53-1; alpha-alpha'-diethyl-4,4'-stilbenediol] or sesame oil were recorded after 1, 4, 7, and 10 months of treatment. des-exposed uteri were found to be hypoplastic, less responsive to the growth-promoting effects of e2, and more likely to develop smooth muscle abnormalities after continuou ... | 1985 | 3855473 |
| gonadotropin-releasing hormone within the organum vasculosum lamina terminalis in the ovariectomized, estrogen/progesterone-treated rat: a quantitative immunocytochemical study using image analysis. | no specific function has been ascribed to the high gonadotropin-releasing hormone (gnrh) content of the organum vasculosum lamina terminalis (ovlt). the objective of this study was to determine whether levels of gnrh within the ovlt are altered during cyclic gonadotropin secretion. gnrh levels were determined at various times during an estrogen/progesterone (e/p)-induced lh surge. groups of e/p and sesame oil-treated animals were decapitated at 12.00 h, 14.00 h, 16.00 h, 18.00 h, and 22.00 h fol ... | 1985 | 3896396 |
| alterations in the onset of ovulatory failure and gonadotropin secretion following steroid administration to lightly androgenized female rats. | the present studies were designed to characterize the gonadotropin response to exogenous steroids in neonatally androgenized female rats in various states of reproductive decline. female rats were androgenized by the administration of a single injection of testosterone propionate (tp) (10 or 100 micrograms) at 5 days of age. control rats received sesame oil. treatment with 100 micrograms tp resulted in persistent vaginal estrus (pve) from the onset of vaginal introitus. treatment with 10 microgr ... | 1985 | 3921068 |
| the effect of pelleting feed supplemented with lysine on its utilization by young pigs. | the aim of the experiment was to study the effect of pelleted and meal-form of a diet supplemented with lysine on passage rate through the digestive tract (dt) and utilization by young pigs. the experiment was carried out on 20 young boars of about 10 kg live weight, divided into 3 groups. the experimental diet composed of feeds of plant origin (barley 80.0%, sesame meal 10.6%, soybean meal 7.0%; total crude protein 15.3%) and supplemented with l-lysine to total level of 0.8% was fed twice daily ... | 1985 | 3927873 |
| the pattern of progesterone secretion in hypophysectomized rats bearing pituitary transplants: effects of hysterectomy, estrogen, and indomethacin. | cyclic rats were hypophysectomized and their pituitaries transplanted beneath the kidney capsule on day 2 (day 1, ovulation); they were then either hysterectomized or sham hysterectomized (uterus intact rats) and injected sc daily with either 1.0 micrograms 17 beta-estradiol (e1) or with the sesame oil vehicle until autopsy on day 105. blood samples were drawn by jugular venipuncture every 2 to 3 days until day 21 and once weekly thereafter. in these rats the serum progesterone level rose until ... | 1985 | 3967627 |
| n-(3,5-dichlorophenyl)succinimide nephrotoxicity in the fischer-344 rat. | the nephrotoxic potential of n-(3,5-dichlorophenyl)succinimide (ndps) was examined, in male fischer-344 rats. rats were administered ndps (0.1, 0.2, 0.4 or 1.0 mmol/kg intraperitoneally (i.p.) or sesame oil (2.5 ml/kg, i.p.), and renal function was monitored at 24 and 48 h. ndps (0.1 mmol/kg) stimulated organic ion uptake at 48 h. ndps (0.2 mmol/kg) produced diuresis but did not alter blood urea nitrogen (bun), kidney weight or organic ion uptake by renal cortical slices at 48 h. high-dose ndps ... | 1985 | 3975935 |
| acute nephrotoxicity of n-phenyl and n-(monochlorophenyl) succinimides in fischer 344 and sprague-dawley rats. | the experimental fungicide n-(3,5-dichlorophenyl)succinimide (ndps) has been shown to be nephrotoxic in sprague-dawley and fischer 344 rats. the purpose of this study was to evaluate the role of the chlorine atoms in ndps-induced nephropathy. male sprague-dawley or fischer 344 rats received a single intraperitoneal injection of a phenylsuccinimide (0.4 or 1.0 mmol/kg) or sesame oil (2.5 ml/kg), and renal function was monitored at 24 h and 48 h. in sprague-dawley rats urine volume was increased b ... | 1985 | 3992588 |
| effects of benzene and other organic solvents on the decarboxylation of some brain aromatic-l-amino acids. | the intraperitoneal administration of benzene produced marked increases in mouse striatal concentrations of beta-phenylethylamine, p-tyramine and, to a lesser extent, m-tyramine. similar increases were observed in rat striatal p- and m-tyramine. the subcutaneous administration of benzene dissolved in sesame oil increased mouse striatal p-tyramine but did not change m-tyramine. benzene administration to mice pretreated with p-tyrosine produced marked increases in mouse striatal p-tyramine as well ... | 1985 | 3994754 |
| some functional properties of oilseed proteins. | oilseeds have potential food uses because of their high protein content. besides, these proteins when added to a type of foods, supply desirable functional properties, such as whipping capacity and viscosity, emulsification and water and oil holding capacities. rapeseed and soybean protein isolates were found to possess whipping capacity followed by those of sunflower, peanut, sesame, cottonseed and safflower. the addition of sugar improved the whipping properties of oilseed proteins. the whippi ... | 1985 | 4000248 |
| structure-nephrotoxicity relationships for para-substituted n-phenylsuccinimides in sprague-dawley and fischer 344 rats. | n-(3,5-dichlorophenyl)succinimide (ndps) has proven to be one of the most nephrotoxic compounds of a series of n-(halophenyl)succinimides. previous studies in our laboratory have demonstrated that chlorine content and position on the phenyl ring are important determinants for ndps-induced nephrotoxicity. the purpose of this study was to investigate the relationship between the electron donating or withdrawing nature of phenyl group substituents and the nephrotoxic potential of the corresponding ... | 1985 | 4024126 |
| mesenteric vascular reactivity in dexamethasone-treated hypertensive rats. | possible alterations in mesenteric vascular reactivity to norepinephrine, angiotensin ii, and arginine vasopressin and its relationship to prostaglandins in dexamethasone-induced hypertension in rats were investigated. the animals were treated with dexamethasone or its vehicle (sesame oil) for 1 day (1.8 mg/kg) and for 14 days (1.8 mg/kg/wk). the superior mesenteric artery with its branches was isolated and perfused with tyrode's solution at a constant flow rate of 5 ml/min. administration of no ... | 1985 | 4030047 |
| promotion of the selective lymphatic delivery of cyclosporin a by lipid-surfactant mixed micelles. | the absorption of an immunosuppressive drug, cyclosporin a (csa), with the aid of lipid-surfactant mixed micelles from the rat gastrointestinal (gi) tract and lymphatic delivery were studied. the administration of csa in oily solution, sesame oil or linolic acid, into the rat duodenum indicated a small amount of csa both in the plasma and lymph for about 6 h. the administration of csa in the mixed micellar solution composing of linolic acid and hco-60, polyoxyethylated (60 mol) hydrogenated cast ... | 1985 | 4032221 |
| the extrarenal effects of aldosterone on the distribution of extracellular fluid in conscious adrenalectomized-nephrectomized rats. | in order to examine the extrarenal roles of aldosterone in cardiovascular homeostasis, the present study compared blood pressure, extracellular fluid volume (ecfv) and plasma volume (pv) in the three following groups: 10 nephrectomized (nx) rats, 10 nephrectomized-adrenalectomized (nx-ax) rats, and 10 nx-ax and aldosterone-treated (nx-ax-a) rats. two-hundred and fifty micrograms of aldosterone, mixed with sesame oil, was given subcutaneously in the nx-ax-a rats. mean arterial pressure (map) was ... | 1985 | 4034372 |
| absence of progesterone effects on chlamydial genital infection in female guinea pigs. | the effect of progesterone alone and in combination with estradiol was investigated in ovariectomized and gonadally intact female guinea pigs infected with the chlamydial agent of guinea pig inclusion conjunctivitis (gpic). the course of the infection, as determined by the percentage of cells with gpic (chlamydia) inclusions in giemsa-stained vaginal scrapings, was not affected in animals receiving 5.0 mg of progesterone daily. progesterone had no influence on the enhancement of infection by est ... | 1985 | 4035522 |
| the embryotoxicity of gossypol. | in utero development was analyzed in pregnancies that resulted from matings between gossypol-treated male rats and untreated female rats and in pregnancies in which gossypol was administered to the pregnant rat only. gossypol treatment of males had no effect on the outcome of pregnancy. there was no significant effect on resorption, fetal growth, or malformation rate. similarly, gossypol administered to pregnant dams at stages during organogenesis had no observable effect on pregnancy. under the ... | 1985 | 4049283 |
| effect of succinimide ring modification on n-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in sprague-dawley and fischer 344 rats. | n-(3,5-dichlorophenyl)succinimide (ndps) has proven to be an effective experimental agricultural fungicide. however, ndps produces marked nephrotoxicity in sprague-dawley and fischer 344 rats. the purpose of this study was to determine the importance of an intact, unsubstituted succinimide ring for acute ndps-induced nephrotoxicity. structural modifications included ring opening, reduction of one or both carbonyl groups, breaking the ethylene carbon-carbon bond and mono- or dialkyl substitution ... | 1985 | 4060170 |
| effects of 17 beta-estradiol and methyl testosterone on the activity of the thyroid gland in rainbow trout, salmo gairdneri richardson. | methyl testosterone (mt) and 17 beta-estradiol (e2), suspended either in sesame oil (and injected on alternate days) or in warm hydrogenated coconut oil (and injected once in the form of an "implant"), were administered intraperitoneally to nonvitellogenic rainbow trout (salmo gairdneri richardson). when given as sesame oil injections e2 significantly reduced plasma triiodo-l-thyronine (t3) levels and thyroid epithelial cell height (teh), but had no apparent effect on plasma l-thyroxine (t4) lev ... | 1985 | 4076757 |
| nitrogen transformation in soils. ii. in sandy soil under horse-bean and sesame in a two years' rotation. | 1973 | 4353660 | |
| tetrahydrocannabinol, sesame oil and biogenic amines: a preliminary report. | 1974 | 4407739 | |
| the effect of copper salts on ovulation, especially on hypothalamic ovulatory hormone releasing factor. | in this study the influence of copper salts on the hypothalamic ovulatory hormone releasing factor was studied in vivo. 321 healthy adult female rabbits were used. 85 mcg of estradiol-17-beta-benzoate dissolved in 1 ml of sesame oil was injected intramuscularly for 2 days. absence of ovulation and an active corpus luteum were confirmed by laparotomy. (for the measurement of lh rats were injected with 1000 iu of pms and 64 hours later with 50 iu of hcg subcutaneously. bioassay was conducted ... | 1972 | 4648397 |
| the lysine requirement of growing chicks fed sesame meal-gelatin diets at three protein levels. | 1973 | 4709408 | |
| effect of aureofungin on seedling mortality and growth of two varieties of sesame with seed-borne infection of fusarium solani. | 1973 | 4763647 | |
| nitrogen retention of adult human subjects who consumed wheat and rice supplemented with chickpea, sesame, milk, or whey. | 1973 | 4800394 | |
| effect of dehulling and heat processing on nutritional value of sesame proteins. | 1974 | 4826076 | |
| direct action of estradiol on rat mammary tumors. | this study reports a direct action of 17-beta-estradiol on protein synthesis by 7, 12-dimethylbenz (alpha) anthracene (dmba) induced rat mammary tumors. sprague-dawley female rats were given 20 mg of dmba in sesame oil by gastric tube. mammary tumors developed. when tumors reached 1.5 to 2 cm in diameter, animals were ovariectomized. at 4-7 days later animals were killed and tumors removed. microscopic examination confirmed the tumors to be carcinoma of adenoid cystic variety with regressiv ... | 1974 | 4855761 |
| effect of preservatives on the heat sterilization of sesame oil. | 1967 | 4964774 | |
| the availability of calcium from mexican and californian sesame meals. | 1967 | 4965061 | |
| influence of quinestrol on th histology and phosphatase activity of the simian uterus. | the purpose of this study was to evaluate the endometrial acid and alkaline phosphatase activity in rhesus monkeys chronically treated for 24 months with 3 levels of quinestrol (17-ethynlestradiol cyclopentyl ether). the 3 levels were: 1) 4 animals, 4 mcg/kg;2) 3 animals, 20mcg/kg; 3) 4 animals 100 mcg/kg. there were 4 animals included as sesame oil controls. all monkeys receiving quinestrol had some degree of cystic endometrial hyperplasia, dose-related, ranging from trace, to weak, to moder ... | 1971 | 4994113 |
| studies of dimethylpolysiloxane compared to sesame oil as a vehicle for progesterone injection. | 1972 | 5029461 | |
| effect of histidine on tibia alkaline phosphatase of chicks fed zinc-deficient sesame meal diets. | 1972 | 5074345 | |
| the amino acid sequence of sesame (sesamum indicum l.) and castor (ricinus communis l.) cytochrome c. | the amino acid sequences of sesame (sesamum indicum l.) and castor (ricinus communis l.) cytochrome c were determined by using 1.5mumol of protein from each species. both molecules consist of a single chain of 111 amino acid residues and are homologous with other mitochondrial cytochrome c molecules. both have an n-acetylated ;tail' of eight amino acids and two in-n-trimethyl-lysine residues, as also reported for wheat germ (delange, glazer & smith, 1969) and mung-bean cytochrome c (thompson, la ... | 1971 | 5119781 |
| [the possible use of sesame flour for human consumption]. | 1971 | 5136115 | |
| amino acid supplementation of a protein-rich mixture of crushed groundnut, chickpea and sesame. | 1970 | 5418186 | |
| reduction of carcinogen-induced breast cancer in rats by an anti-fertility drug. | the dmba (dimethylbenz[a]anthracene)-induced mammary cancer systems seemed to be an ideal model for the study of the influence of oral contraceptives (ocs) on endocrine-related cancers. groups of 20 female sprague-dawley rats, age 40-45 days, weight approximately 150 g, were given 3.0 or 0.3 mg of crystalline enovid suspended in 1 ml of sesame oil per dose for 45 days. the controls consisted of a group of 20 rats given a single dose of 15 mg of dmba, of 2 groups of 10 rats administered daily d ... | 1968 | 5641718 |
| studies on sesame oil cake meal (sesamum indicum) in chick mash. | 1968 | 5693493 | |
| influence of two contraceptives on induction of mammary cancer in rats. | this study assesses the influence of 2 popular oral contraceptive (oc) agents that seem to act like progesterone in the induction of mammary cancer in rats. 35 day old rats were maintained on a diet of wayne lab-blox ad lib, which was tested by the manufacturer for freedom from estrogen. at 48 days, 1/2 of the rats were subjected to bilateral oophorectomy. at 49 days, all of the animals except the control group were started on one of the 2 ocs, either enovid or norlestrin at 2 different dosag ... | 1965 | 5862377 |
| amino acid supplementation of a sesame meal diet. | 1967 | 6081748 |