Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| recent clinical experience with dronabinol. | dronabinol, delta-9-tetrahydrocannabinol in sesame oil, has been used for several years as an antiemetic for patients receiving cancer chemotherapy. in combination studies with prochlorperazine, enhancement of efficacy, as measured by duration of episodes of nausea and vomiting and by severity of nausea, has been found. the incidence of psychotropic effects from dronabinol appears to be decreased by concomitant administration of prochlorperazine. in open pilot studies, dronabinol caused weight g ... | 1991 | 1666930 |
| organochlorine pesticide residues in different indian cereals, pulses, spices, vegetables, fruits, milk, butter, deshi ghee, and edible oils. | a total of 244 samples of cereals (wheat flour, rice, and maize), pulses (arhar, moong, gram, lentil, and black gram), spices (turmeric, chili, coriander, and black pepper), vegetables (potato, onion, spinach, cabbage, brinjal, and tomato), fruits (mango, guava, apple, and grape), milk, butter, deshi ghee, and edible oils (vegetable, mustard, groundnut, and sesame) collected from different cities of northern province (utter pradesh) were analyzed by gas liquid chromatography for the presence of ... | 1990 | 1698760 |
| in vivo 5-hiaa release from the anterior hypothalamus in the ovariectomized and estradiol treated rat following perfusion with progesterone. | in the present study the frequency and magnitude of the release of 5-hydroxyindoleacetic acid (5-hiaa) was measured from the anterior hypothalamus of ovariectomized (ovx) and ovx rats treated with estradiol (e2). female, holtzman strain rats were maintained on a photoperiod of 14 h light from 0100 to 1500 h and experiments performed from 0900 to 1700 h. animals exhibiting four-day estrous cycles (250-300 gms) were ovx (20 days recovery) and a push-pull-cannula (ppc) implanted and stereotaxically ... | 1990 | 1699143 |
| estrogen induces ultrastructural changes in progesterone receptor-containing gaba neurons of the primate hypothalamus. | estrogen affects gonadotrophin levels and sex behavior in monkeys. this action could be via inhibitory gaba-ergic neurons in the hypothalamus. we tested for direct estrogen actions on such neurons. seven days after ovariectomy (ovx) or ovx + estrogen treatment (10 mg estradiol valerate in 1 ml sesame oil s.c. on the day of ovx), light- and electron-microscopic double immunostaining procedures were used for simultaneous visualization of immunoreactivity for progesterone receptors (pr) and glutami ... | 1991 | 1723787 |
| effects of prenatal administration of testosterone and cortisone on the reproductive system of the female rat. | testosterone propionate, cortisone, or sesame oil vehicle were given to rats during the last week of pregnancy so that effects of the hormones on anogenital distance, breeding capacity and vaginal opening of the female progeny could be contrasted. testosterone significantly increased anogenital distance and delayed vaginal opening of progeny. when females that had been exposed to testosterone in utero were tested for breeding capacity, a significantly smaller number mated than in the control gro ... | 1992 | 1740970 |
| estrogens reduce bone loss in the ovariectomized, lactating rat model. | estrogen treatment of ovariectomized, lactating rats improved retention of bone mineral mass by 15-25% compared to ovariectomized, lactating rats receiving vehicle only. on the second day postpartum all lactating rats were ovariectomized and were placed along with age-matched non-mated controls on a whole-wheat flour-based diet with 0.1% calcium and 0.4% phosphorus. on day 6 postpartum estrogen treatment was begun with either implantation of a slow-release 17 beta-estradiol pellet or with the fi ... | 1991 | 1747566 |
| estrogen increases spine density in ventromedial hypothalamic neurons of peripubertal rats. | using the single-section golgi impregnation technique, sex differences in hypothalamic ventromedial (vmn) neurons of gonadectomized juvenile and peripubertal rats were assessed. the effect of estrogen treatment on vmn neurons was also investigated. juvenile rats were gonadectomized at 16 days of age and peripubertal rats at 36 days. at 5 days after surgery, the rats were injected with estradiol benzoate (20 micrograms/kg) or sesame oil for 2 days after which they were perfused and the brains pro ... | 1991 | 1758578 |
| 4-mapc, a 5 alpha-reductase inhibitor, reduces rat ventral prostate weight, dna, and prostatein concentrations. | several compounds, such as 4-mapc (4-methyl-3-oxo-4-aza-5 alpha-pregnane-20- carboxylate), that inhibit conversion of testosterone (t) to dihydrotestosterone (dht) by 5 alpha-reductase have been demonstrated to reduce prostate size in rats and dogs. the current studies were undertaken to determine if this effect is due to a reduction in cell number, in epithelial cell synthetic activity, or both. eight-week-old intact rats were treated daily for 14 days with sesame seed oil, 4-mapc (10 mg/kg), 4 ... | 1991 | 1765567 |
| acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat: part 2. | acute intravenous administration of the phytoestrogen genistein (g) blocks the gonadotropin-releasing hormone-(gnrh)-induced rise of luteinizing hormone (lh) in ovariectomized rats. the present experiments were performed to determine whether subacute administration of g or the mycoestrogens zearalenone and zearalenol would affect gnrh-induced or progesterone-induced lh secretion in ovariectomized rats. charles river cd rats were ovariectomized and used 2 to 5 weeks later. blood samples were obta ... | 1991 | 1807544 |
| effects of methoxychlor on the reproductive system of the adult female mouse. 1. gross and histologic observations. | the purpose of this study is to examine the effects of the pesticide methoxychlor (mxc) on the reproductive system of the adult female mouse. sexually mature (7- to 8-week) virgin female cd-1 mice were exposed to 1.25, 2.5, or 5.0 mg mxc (50% technical grade) via oral gavage for 5 consecutive days each week for either 2 or 4 weeks. control groups received either 0.025 mg estradiol-17 beta (e-17 beta) or the sesame oil vehicle for the same time period. vaginal smears were taken daily, and weights ... | 1991 | 1807545 |
| mycoflora associated with five species of freshwater leeches. | twenty-two species belonging to 11 genera of zoosporic fungi were collected from 10 freshwater sites and from five species of leeches on sesame and hemp seeds, maize grains and pinus pollen grains as baits at 22 degrees c. dictyuchus, achlya, pythium, allomyces and saprolegnia were the most common genera. the highest population of zoosporic fungi was estimated from batracobdelloides tricarinata, the lowest from barbronia assiuti. in addition fifty-three species and 1 variety representing 23 terr ... | 1991 | 1818104 |
| inhibition of cholesterol absorption and synthesis in rats by sesamin. | the effects of sesamin, a lignan from sesame oil, on various aspects of cholesterol metabolism were examined in rats maintained on various dietary regimens. when given at a dietary level of 0.5% for 4 weeks, sesamin reduced the concentration of serum and liver cholesterol significantly irrespective of the presence or absence of cholesterol in the diet, except for one experiment in which the purified diet free of cholesterol was given. on feeding sesamin, there was a decrease in lymphatic absorpt ... | 1991 | 1856608 |
| comparison of sesame cake and cottonseed as supplementary sources of protein to weaned n'dama bull calves in the gambia. | the potential for increased productivity of n'dama cattle in response to small supplementary inputs of proteinaceous by-products has been shown to be substantial under village husbandry conditions in the gambia. young n'dama bulls were used to compare sesame cake with cottonseed as sources of supplementary protein during the wet and early dry seasons of 1987. they were fed 0, 40, 80 or 160 g crude protein/day in these forms for four months. supplementation significantly increased growth rate fro ... | 1991 | 1858165 |
| effect of estrogen and progesterone on the growth of human ovarian dysgerminoma heterotransplanted to athymic nude mice. | the effects of estrogen and progesterone on the growth of dysgerminoma of ovary heterotransplanted to ovariectomized athymic nude mice (ovx-nus) were examined. ovx-nus were divided into 6 groups and a subcutaneous injection of either 1 micrograms or 10 micrograms of estradiol (e1 or e10), 0.1 mg or 1 mg of progesterone (p0.1 or p1), or a combination treatment of e1 and p1 (e1 + p1), or sesame oil as a vehicle control (oil) was given every other day for 2 weeks. tumor size was recorded every day ... | 1991 | 1867584 |
| ethanol inhalation and dietary n-6, n-3, and n-9 fatty acids in the rat: effect on platelet and aortic fatty acid composition. | the effects of 18-carbon n-6, n-3, and n-9 fatty acid diets and ethanol exposure on the fatty acyl composition of platelets and vascular tissue were examined. an experimental design was devised to control the dietary content of 18-carbon fatty acids. the levels of 18:3n6, 18:3n3 and 18:1n9 were varied by a formulation of dietary oils which contained similar proportions of 18:2n6. male sprague-dawley rats were fed a purified diet containing 11% by weight of either borage oil (bor) rich in 18:3n6, ... | 1991 | 1877733 |
| effect of buthionine sulfoximine on n-(3,5-dichlorophenyl)-2-hydroxysuccinimide and n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid nephrotoxicity. | n-(3,5-dichlorophenyl)succinimide (ndps) is an agricultural fungicide which induces acute tubular necrosis as its primary toxicity. two ndps metabolites, n-(3,5-dichlorophenyl)-2-hydroxysuccinimide (ndhs) and n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (ndhsa) previously have been shown to be more potent nephrotoxicants than ndps. in addition, buthionine sulfoximine (bso), a glutathione synthesis inhibitor, was found to attenuate ndps-induced nephrotoxicity. the purpose of this study was to ... | 1991 | 1882389 |
| trichloroaniline effects on renal function in vivo and in vitro. | previous studies have demonstrated that mono- and dichloroanilines are capable of inducing acute renal failure in vivo and altering organic ion accumulation by renal cortical slices in vitro. the purpose of this study was to determine the nephrotoxic potential of 4 trichloroaniline (tca) isomers in vivo and to examine their effects on organic ion accumulation in vitro. in the in vivo experiments, male fischer-344 rats (4 rats/group) were administered a tca (0.8 or 1.5 mmol/kg) intraperitoneally ... | 1991 | 1882391 |
| facilitation of dimethylbenz[a]anthracene-induced rat mammary tumorigenesis by restraint stress: role of beta-endorphin, prolactin and naltrexone. | in order to investigate the involvement of opioid peptides and prolactin in stress-facilitated mammary cancer, we studied the effect of chronic restraint stress on dimethylbenz[a]-anthracene (dmba)-induced mammary tumorigenesis and the effect of an opiate antagonist, naltrexone, on this process. female fischer-344 rats (n = 160) were administered 15 mg dmba/ml of sesame oil/rat by intragastric intubation. eighty rats were subjected to daily 30 min restraint stress in a plastic cylinder, and 80 r ... | 1991 | 1901524 |
| sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis. | incubation with sesame oil increases the mycelial dihomo-gamma-linolenic acid content of an arachidonic acid-producing fungus, mortierella alpina, but decreases its arachidonic acid content [shimizu, s., k. akimoto, h. kawashima, y. shinmen and h. yamada (1989) j. am. oil chem. soc. 66, 237-241]. the factor causing these effects was isolated and identified to be (+)-sesamin. the results obtained in experiments with both a cell-free extract of the fungus and with rat liver microsomes demonstrated ... | 1991 | 1943494 |
| role of sympathetic nerves in effects of estradiol on rat white adipose tissue. | two experiments examined the role of the sympathetic nerves in estradiol-induced fat pad weight losses in ovariectomized (ovx) rats. rats were ovx, and the retroperitoneal white adipose tissue (rwat) was unilaterally denervated 4 wk later. after 14 days of treatment with estradiol benzoate (eb, 2 micrograms/day), the intact pads lost 23% more weight than the denervated pads. there was no effect of denervation on fat pad weight or on cytosol estrogen receptor concentration in rwat in the animals ... | 1991 | 1992827 |
| effect of injected bovine interferon-alpha i1 on estrous cycle length and pregnancy success in sheep. | in exp. 1 twice daily i.m. injections of 2 mg recombinant bovine ifn-alpha i1 (rboifn-alpha i1) (n = 24) or placebo (n = 25) were administered to ewes from day 12 to day 16 during a normal oestrous cycle. treatment did not increase (p greater than 0.10) oestrous cycle length (20.7 +/- 1.2 versus 18.5 +/- 1.4 days). in exp. 2, ewes were injected twice daily with 2 mg ifn (n = 34) or placebo (n = 36) from days 11 to 18 after natural mating. the rboifn-alpha i1 significantly (p = 0.05) improved pre ... | 1991 | 1995858 |
| effect of calcium antagonism by nifedipine and chlorpromazine on acute n-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in fischer 344 rats. | the nephrotoxicity induced by a wide variety of chemical compounds can be attenuated by agents which modify calcium ion (ca2+) movement across membranes or calcium-dependent processes. the purpose of this study was to examine the ability of nifedipine, a calcium channel blocking drug, and chlorpromazine (cpz), an antagonist of many calcium-dependent processes, to attenuate the nephrotoxicity induced by the agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) or its metabolite n-(3,5-d ... | 1991 | 1996465 |
| enhancement of in vivo humoral immunity by estrogen: permissive effect of a thymic factor. | physiological levels of estrogen enhance humoral immune responses. several in vitro studies indicate the hormone to have a direct effect on immune cells, and other studies show that estrogen may affect humoral immunity indirectly through the thymus. therefore, we have conducted experiments to investigate the requirement of the thymus in the enhancement of humoral immune responsiveness by estrogen. in exp i, adult ovariectomized lewis rats were thymectomized or sham thymectomized and given estrad ... | 1991 | 1999157 |
| the use of sesame oil and other vegetable oils in the inhibition of human colon cancer growth in vitro. | sesame contains large quantities of the essential polyunsaturated fatty acid (pufa), linoleic acid, in the form triglycerides. the antineoplastic properties of many pufas such as linoleic acid and their metabolites are known. we tested the hypothesis that natural vegetable oils, such as sesame oil and its component linoleic acid, when added to human colon adenocarcinoma cells growing in tissue culture would inhibit their growth and that normal colon cells would not be similarly affected. three h ... | 1991 | 2018355 |
| distribution and regulation by estrogen of progesterone receptor in the hypothalamus of the cat. | the diencephalon is critically involved in the estrogen-dependent receptor-mediated stimulation of respiration by progesterone in cats. to identify a neuroanatomic basis for this effect of progesterone, the diencephalon of the ovariectomized cat was examined immunohistochemically with an antiprogesterone receptor (anti-pr) monoclonal antibody. no immunostaining was found in ovariectomized animals pretreated with sesame oil alone. in contrast, numerous cells in the ventromedial aspect of the hypo ... | 1991 | 2019267 |
| synergistic induction of aromatase activity in the rat brain by estradiol and 5 alpha-dihydrotestosterone. | estrogens are produced locally from androgen precursors by cells within the hypothalamus and preoptic area (poa). the activity of the aromatase enzyme complex responsible for this intracellular conversion is controlled by gonadal steroids. the purpose of this study was to determine: (1) whether estrogen acts together with androgen to regulate aromatase activity (aa) and (2) whether nuclear androgen receptor levels are increased after exposure to combined treatment with estradiol benzoate (eb) an ... | 1991 | 2046863 |
| preventive effect of angiotensin i on weight reduction in the adrenal glands of doca/salt hypertensive rats. | we examined the effect of angiotensin i (ai), without the effect of angiotensin ii (aii) converted from ai, on the weight of the adrenal glands, adrenal corticosterone (b) and adrenal aldosterone under conditions where the renin-angiotensin system was suppressed, since a reduction in the size of the adrenal glands is often observed in doca/salt hypertensive rats. sixty male wistar rats fed on a 1% nacl solution were divided into 6 groups as follows: a) salt group: received sesame oil and vehicle ... | 1990 | 2083530 |
| acute effect of basic fibroblast growth factor on secretion of prolactin as assessed by the reverse hemolytic plaque assay. | the effect of basic fibroblast growth factor (bfgf) on acute secretion of prl by pituitary lactotrophs was examined under basal conditions and after treatment with trh or dopamine. we used the reverse hemolytic plaque assay (rhpa) to determine the amount of prl secreted per lactotroph and the percentage of pituitary cells secreting prl. young (2- to 3-month-old) female sprague-dawley rats were ovariectomized and 1 week later implanted with a silastic capsule containing 180 micrograms/ml estradio ... | 1990 | 2105207 |
| effect of nicotine on 7,12-dimethylbenz[a]anthracene carcinogenesis in hamster cheek pouch. | we divided 40 male syrian golden hamsters into four groups of 10 animals each, and we treated both cheek pouches of each hamster three times a week as follows: group 1, 50 microl of sesame oil; group 2, 50 microl of 6% nicotine in sesame oil; group 3, 50 microl of 1% 7,12-dimethylbenz[a]anthracene (dmba) in sesame oil; and group 4, 50 microl of 1% dmba in 6% nicotine in sesame oil. cheek pouches were examined clinically and histologically after 12 weeks of treatment. hamsters treated with dmba a ... | 1990 | 2110268 |
| tumour reducing and anticarcinogenic activity of selected spices. | tumour reducing activity of extracts of eight commonly used spices in india were studied in mice transplanted intraperitoneally with ehrlich ascites tumour. oral administration of extracts of black pepper, asafoetida, pippali and garlic could increase the percentage of life span in these mice by 64.7%, 52.9%, 47% and 41.1%, respectively. however intraperitoneal administration of spice extracts did not produce any significant reduction in tumour growth except for sesame (38.8%). garlic extract an ... | 1990 | 2110862 |
| the effects of porcine somatotropin and dietary lysine on growth performance and carcass characteristics of finishing swine. | seventy-two finishing pigs (initial weight = 57.6 kg) were utilized to determine the effects of porcine somatotropin (pst) and dietary lysine level on growth performance and carcass characteristics. pigs were injected daily with 4 mg pst in the extensor muscle of the neck and fed either a pelleted corn-sesame meal diet (.6% lysine, 17.8% cp) or diets containing .8, 1.0, 1.2 or 1.4% lysine provided by additions of l-lysine.hcl. all diets were formulated to contain at least twice the required amou ... | 1990 | 2123846 |
| age-related differences in the release of luteinizing hormone and gonadotropin-releasing hormone in ovariectomized rats. | the effect of aging on the release of gonadotropin-releasing hormone (gnrh) in vitro and of luteinizing hormone (lh) both in vivo and in vitro in ovariectomized (ovx) rats was studied. old (21-24 months) and young (3-4 months) rats were ovx before use. they were injected subcutaneously with estradiol benzoate (25 micrograms/kg) or sesame oil for 3 days and then challenged with gnrh (0.5, 2 or 10 micrograms/kg) via a jugular catheter. blood samples were collected immediately before and at 5, 10, ... | 1990 | 2125700 |
| inverse relationship between poly (adp-ribose) polymerase activity and 2',5'-oligoadenylates core level in estrogen-treated immature rat. | the activity of poly (adp-ribose) polymerase (adprp) and the content of 2',5'-oligodenylates core (2',5'an; n = 2,3 and 4) were measured in homogenates of the uterus and of the liver of immature rats immediately before (time 0) or at different times after injection of estradiol-valerate. adprp activity increased gradually, starting 6 hours after estrogen injection, for about 4 days. instead, the content of 2',5'an decreased by about 50% within 6 hours, and thereafter more slowly for 4 days to ab ... | 1990 | 2126338 |
| administration of testosterone fails to attenuate axotomy-induced motoneuron loss but results in castration-like effect in young male rats. | it was shown previously that the severity of motoneuron loss induced by nerve transection in rats 3 or 6 weeks of age was correlated inversely with the level of testosterone in circulation [yu, w.h.a., exp. neurol. 102: 230-235, 1988], and that administration of testosterone to female rats attenuated axotomy-induced neuronal cell loss in a dose-dependent manner [yu, w.h.a., j. neurosci. 9: 3908-3914, 1989]. the present study was undertaken to examine whether elevation of the level of plasma test ... | 1990 | 2126609 |
| left ventricular structure and performance in middle-aged rats with deoxycorticosterone acetate-salt hypertension. | we designed this study to establish the structural and functional characteristics of the hypertrophied left ventricle of middle-aged rats during mineralocorticoid-salt hypertension. treatment was initiated at 12 months of age, and the rats were studied at either 13 or 15 months of age (after 1 or 3 months of treatment). all rats were unilaterally nephrectomized. one group received deoxycorticosterone acetate (doca) injections (30 mg/kg s.c.) biweekly and 1% nacl drinking water (doca salt), and t ... | 1990 | 2137430 |
| n-(3,5-dichlorophenyl)succinimide nephrotoxicity in streptozotocin-induced diabetic rats. | n-(3,5-dichlorophenyl)succinimide (ndps) is an experimental fungicide which induces renal toxicity. the following study examined the nephrotoxicity induced by ndps in streptozotocin (stz) diabetic rats. male fischer 344 (f344) rats were injected with 35 mg/kg stz (i.p.) or citrate buffer. fourteen days after stz or citrate buffer injection, the rats (4-6 rats/group) were injected with (0.4 or 1.0 mmol/kg) ndps or vehicle (sesame oil, 2.5 ml/kg). kidney weight, blood urea nitrogen (bun) levels, m ... | 1990 | 2145659 |
| an investigation of the dissociation and denaturation of legumin by salts using laser light scattering and circular dichroism spectroscopy. | the dissociation of legumin, a 12 s seed storage globulin from pisum sativum, has been studied by laser light scattering and circular dichroism spectroscopy. salts from the hofmeister series, in particular sodium perchlorate, were used as dissociating agents. the mr 360,000 hexameric protein was found to dissociate first to trimers and further to monomers and the number of amino acids involved in the trimer-trimer interaction estimated to be 23(+/-4). native legumin appears to be more strongly b ... | 1990 | 2153027 |
| endogenous excitatory amino acid neurotransmission regulates the estradiol-induced lh surge in ovariectomized rats. | the present study was designed to evaluate the relative contribution of endogenous excitatory amino acids to the control of the estradiol-induced lh surge using specific blockers for n-methyl-d-aspartic acid (nmda) and non-nmda receptor types. adult female rats ovariectomized for 2-3 weeks were implanted with third ventricular cannulae one week before the experiments. silastic capsules (3 cm active surface) containing estradiol benzoate (250 micrograms/ml dissolved in sesame oil) were implanted ... | 1990 | 2155110 |
| interaction of naltrexone with postnatal administration of testosterone and estrogen on neurobehavioral sexual differentiation in rats. | the present study examined whether some effects of gonadal sex hormones on neurobehavioral sexual differentiation might be mediated by endogenous opioids. male and female pups were administered sesame oil, testosterone propionate (tp; 25 micrograms) or estradiol benzoate (eb; 10 micrograms) on postnatal days 2 and 3. half of each group was also administered naltrexone (n; 50 micrograms) twice daily on these two days. females were studied for effects of the treatments on puberty. males and female ... | 1990 | 2158483 |
| effects of early exposure to diethylstilbestrol on cellular protein expression by mouse vaginal epithelium and fibromuscular wall. | epithelia and fibromuscular walls were dissociated from the vaginae of ovariectomized balb/ccrgl mice (ca. 41 days old) exposed neonatally to diethylstilbestrol (des) or sesame oil and purified by centrifugation through percoll density gradients. neonatal exposure to des caused the vaginal epithelium to become permanently proliferated and partially keratinized; the control epithelium was low cuboidal. the major cellular proteins expressed in each tissue compartment were examined by two-dimension ... | 1990 | 2172995 |
| effect of long-term administration of testosterone oenanthate on sympathetic neurotransmission to rat isolated seminal vesicles. | 1. the effects of prolonged administration of testosterone oenanthate (te) on sympathetic neurotransmission to the rat isolated seminal vesicle were examined. 2. te was administered at either 1.2 or 2.4 mg/kg subcutaneously (s.c.) thrice weekly for 8 weeks. a separate group of rats was administered the vehicle, sesame oil, 0.5 ml/kg, s.c. at the same regime and used as controls. te administration increased plasma testosterone and dihydrotestosterone levels and seminal vesicle weights. te 2.4 mg/ ... | 1990 | 2176938 |
| relationship between maternal milk pge2 and gastric acid secretion in newborn rats. | we previously demonstrated that in rats gastric acid secretion declines after birth and drops steeply on day 12 of life. in the present study, we investigated the part played in this decline by prostaglandin e2 (pge2) from maternal milk. pge2 content was first measured in the milk of untreated dams 0, 1, 5, 10, 12, 15, and 18 days after parturition. pge2 levels were high during the first 5 days (123.5-200.5 pg/ml), declined significantly between days 10 and 15 (56.6-85.4 pg/ml; p less than 0.05) ... | 1990 | 2240214 |
| estradiol distribution and penetration in rat skin after topical application, studied by high resolution autoradiography. | transdermal pathways and targets in the skin for estradiol were investigated using dry-mount autoradiography. 3h-estradiol-17 beta was applied at doses of 30.1 pmol, 120.4 pmol and 301 pmol/cm2 to shaved rat skin in the dorsal neck region. vehicles were dmso, ethylene glycol or sesame oil. after 2 h of topical treatment with 30.1 pmol 3h-estradiol x cm-2 dissolved in dmso a distinct cellular distribution was apparent. target cells with concentrations of radioactivity were found in epidermis, seb ... | 1990 | 2286532 |
| [a comparative study of c19 steroid-induced hypertension and deoxycorticosterone acetate (doca)-salt hypertension]. | in order to evaluate the hypertensinogenic action of 19-hydroxyandrostenedione (19-oh-ad), which has been reported to be an amplifier of mineralocorticoid, the changes in several humoral factors were observed in 19-oh-ad treated rats as compared to those in doca hypertensive rats. twenty-five male wistar rats were castrated at 11 weeks of age, and the experiments were begun at 12 weeks of age. the rats were divided into 3 groups. the control group (n = 8) was given an s.c. injection of 0.2 ml of ... | 1990 | 2307256 |
| inhibitory effects of technical grade methoxychlor on development of neonatal male mouse reproductive organs. | effects of technical grade methoxychlor (mx), an estrogenic insecticide, and 17 beta-estradiol (e2) were examined on serum testosterone (t) concentrations and growth and histology of neonatal male mouse reproductive organs. male nih/swiss mice received i.p. injections daily from birth to day 9 with one of the following: 10 micrograms e2 or 0.1 or 1.0 mg mx or sesame oil vehicle. the mice were killed on day 10. mx or did not affect body weights or mortality. serum t concentrations in control mice ... | 1990 | 2340338 |
| effect of buthionine sulfoximine on acute n-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in fischer 344 rats. | the experimental agricultural fungicide n-(3,5-dichlorophenyl)succinimide (ndps) has been shown to be a nephrotoxicant in fischer 344 rats. results of a previous study conducted in our laboratory suggested that glutathione might be an important modulator of ndps-induced nephrotoxicity. the purpose of this study was to examine the effect of dl-buthionine-(s,r)-sulfoximine (bso), an inhibitor of glutathione synthesis, on ndps-induced renal effects. male fischer 344 rats received an intraperitoneal ... | 1990 | 2356574 |
| corpus callosum: effects of neonatal hormones on sexual dimorphism in the rat. | the rat's corpus callosum is sexually dimorphic, with the male's being larger. in addition, giving rats extra stimulation in infancy via handling increases callosal area in males, but not in females. to determine if this dimorphism is testosterone-dependent, male pups were castrated on day 1 of life while females received an injection of testosterone propionate (tp) on day 4. control males had sham surgery and control females received an injection of sesame oil. all animals were handled daily fr ... | 1990 | 2357549 |
| acute toxicity induced by 2-aryl-n-methylsuccinimides. | phensuximide (psx) is a 2-arylsuccinimide useful in the treatment of absence seizures. psx is a mild urotoxicant and is structurally related to n-phenylsuccinimide (nps) and its antifungal derivatives. since substitution of the phenyl ring of nps with chloro or tert-butyl groups can produce compounds with enhanced nephrotoxic potential, it was felt that similar substitutions on the phenyl ring of psx also might produce derivatives with enhanced nephrotoxic potential. three derivatives of psx wer ... | 1990 | 2362080 |
| mycological contamination of ogiri (fermented sesame seeds) during production in sierra leone. | 'ogiri' (fermented sesame seeds) was prepared in the laboratory and at home by selected participants. no fungal participation was observed during the normal fermentation process. however, fungal contamination was observed when improper handling techniques were employed. out of the 49 samples examined, 41 fungal isolates were made. aspergillus spp were the dominant group irrespective of the locality. toxigenic aspergillus included a. flavus link ex fries, a. tamarii kita and a. ochraceus wilhelm. ... | 1990 | 2366851 |
| ocular pharmacokinetics and pharmacodynamics of phenylephrine and phenylephrine oxazolidine in rabbit eyes. | the aqueous humor concentration of phenylephrine and its corresponding mydriatic response were measured over time in new zealand albino rabbit eyes following a 10-microliters topical instillation of a phenylephrine hcl viscous solution (10%) or a phenylephrine oxazolidine (prodrug) suspension in sesame oil (1 and 10%). the bioavailability of a 1% prodrug suspension in the rabbit eye (auc of aqueous humor concentration vs time) was 30% lower than that of a 10% phenylephrine solution (p less than ... | 1990 | 2367315 |
| effect of indomethacin and prostaglandin e2 on structural differentiation of rat endometrium during artificially induced decidualization. | morphological differentiation of uterine stromal and luminal epithelial cells was studied in steroid-injected ovariectomized rats following unilateral intrauterine instillation of sesame oil, phosphate-buffered saline containing gelatin (pbsg), pbsg + indomethacin (im; an inhibitor of prostaglandin synthesis), or pbsg + im + prostaglandin e2 (pge2). the latter two treatments were preceded by a subcutaneous injection of im. uteri were examined by light and electron microscopy at intervals between ... | 1990 | 2375280 |
| acute effects of the antiepileptic succinimides on the urinary tract and potentiation of phensuximide-induced urotoxicity by phenobarbital. | phensuximide (psx), methsuximide (msx) and ethosuximide (esx) are succinimide antiepileptic agents used worldwide in the treatment of absence seizures. a previous study from our laboratory demonstrated that psx (0.3 or 0.6 mmol kg-1 day-1, i.p.) induced urotoxicity following daily administration for 5-7 days in fischer 344 rats, but psx (1.25 mmol kg-1, i.p.) induced only minimal urotoxicity following acute administration. the purpose of this study was to determine the acute nephrotoxic potentia ... | 1990 | 2380483 |
| occurrence of zoosporic and terrestrial fungi in some ponds of kharga oases, egypt. | thirty-nine species belonging to 13 genera of zoosporic fungi were collected from 33 water samples on sesame and hemp seeds as baits at 22 degrees c. five genera were isolated in high occurrence: allomyces (2 species), achlya (9 species), dictyuchus (4 species), pythium (5 species) and saprolegnia (5 species). aphanomyces (4 species) and isoachlya (2 species) were of moderate frequencies. the remaining six genera were less frequent: anisolpidium, brevilegnia, calyptralegnia, leptolegnia, pythiop ... | 1990 | 2384873 |
| ru 486 (mifepristone): induction of dose dependent elevations of estradiol receptor in endometrium from ovariectomized monkeys. | this study was designed to investigate the effect of the anti-progestin ru 486 on estradiol receptor concentrations in the endometrium of monkeys given physiologic estrogen replacement therapy. estradiol-17 beta (e2) silastic implants were inserted infrascapularly into 12 long-term ovariectomized cynomolgus monkeys (macaca fascicularis) resulting in an average peripheral serum level of approximately 100 pg/ml estradiol. on day 6 of e2 treatment four treatment groups were initiated: group i--estr ... | 1990 | 2401709 |
| transmission and scanning electron microscopic study of chlordecone (kepone) induced changes in the male mouse choroid plexus. | to investigate the effects of the estrogenic insecticide chlordecone on the morphology of mouse choroid plexus, 4 different doses (100.0, 250.0, 500.0 and 1000.0 micrograms) of the chemical were administered intraperitoneally to groups of adult males. concurrent with the chlordecone treatments, another group of males received 10.0 micrograms estradiol-17 beta; the control group was treated with sesame oil vehicle. after 15 days of daily chemical injections, the mice were terminated and the choro ... | 1985 | 2409637 |
| monoamine levels and turnover in brain: relationship to priming actions of estrogen. | norepinephrine (ne), dopamine (da) and serotonin (5ht) levels and turnover rates were studied in 8 discrete brain nuclei of ovariectomized rats 24 hours after the administration of 5 microgram of estradiol benzoate (eb) or sesame oil vehicle. this estrogen paradigm, by itself, did not induce sexual behavior or alter lh levels at the time these parameters were evaluated. however, combined with progesterone, the estrogen treatment was sufficient to generate an lh surge and induce sexual receptivit ... | 1986 | 2424572 |
| lack of ovarian responsiveness to gonadotropic hormones in infantile rats sterilized with busulfan. | ovarian responsiveness to fsh and lh was examined in infantile rats treated in utero with busulfan (1,4-butanediol dimethanesulfate), a cytotoxic drug which has been shown to cause selective attrition of germ cells in the rat fetus. pregnant sprague-dawley rats were injected ip on day 13 of gestation with busulfan (10 mg/kg bw) suspended in sesame oil or with sesame oil alone (control). pups were killed on days 6, 8, 10, 12, or 14 postnatally, and trunk blood was collected. the ovaries were remo ... | 1986 | 2426093 |
| the hormone potentiating capability of amino acids on lactational performance in rats injected with 7,12-dimethylbenzanthracene (dmba) during gestation. | dmba administered to pregnant rats caused a significant decrease in mammary gland rna and dna contents on day 1 of lactation. some amino acids had gonadotropic-like and/or estrogenic-like activity. in order to determine the effects of reproductive amino acids on dmba primed mammary gland tissue, female adult virgin long evans rats (12 animals/group) were intraperitoneally injected daily with 1 mg dmba in 0.2 ml sesame oil on days 8 through 12 of pregnancy. on days 8 through 17 of gestation these ... | 1986 | 2427303 |
| destruction of vx2 tumor in rabbits by hyperthermia plus bleomycin suspended in sesame oil. | the combined antitumor effects of local hyperthermia and a simultaneous injection of bleomycin suspended in sesame oil (blm-sesame oil) into the proper hepatic artery were studied in a model of liver cancer in rabbits. fourteen days after inoculation of vx2 carcinoma into the left anterior lobe, 107 rabbits were used for the experiments. local hyperthermia of 43-47 degrees c for 20 minutes was administered directly to the liver tumor via a 915 mhz microwave. in a preliminary study, administratio ... | 1986 | 2429762 |
| ovulatory response of chlordecone (kepone)-exposed mice to exogenous gonadotropins. | the present study assessed the ability of the murine ovary to ovulate in response to exogenous gonadotropins following exposure to an estrogenic pesticide chlordecone (kepone). sexually mature virgin female cd-1 mice were exposed by oral gavage to either 0.062 mg, 0.125 mg or 0.25 mg (2, 4 or 8 mg/kg, respectively) chlordecone for 5 consecutive days for 2, 4, or 6 weeks. control groups received either 0.1 mg estradiol-17 beta (e-17 beta) or the sesame oil vehicle for the same period. during the ... | 1988 | 2459805 |
| chlordecone-induced follicular toxicity in mouse ovaries. | the effect of the pesticide, chlordecone, on murine follicular development was examined. female cd-1 mice were exposed to chlordecone for 5 consecutive days for each of 4 consecutive weeks (0.25 mg/day). controls received sesame oil vehicle or estradiol-17 beta (e-17 beta; 0.1 mg/day) since chlordecone has been ascribed estrogenic activity. animals were sacrificed 24 h following the final exposure. ovaries were removed, serially sectioned, and stained. follicles were classified as small, medium, ... | 1989 | 2485205 |
| effects of age and long term ovariectomy on prolactin secretion, as assessed by the reverse hemolytic plaque assay. | prl secretion from pituitary lactotrophs was assessed using the reverse hemolytic plaque assay in young (2- to 3-month-old), middle-aged (10- to 12-month-old), and middle-aged long term ovariectomized (lt-ovx) rats to investigate whether 1) a change in the percentage of pituitary cells secreting prl is detectable in middle-aged animals, 2) the amount of prl secreted per cell changes with age, 3) aging involves a change in responsiveness to trh and/or dopamine (da), and 4) lt-ovx can prevent any ... | 1989 | 2491812 |
| castration and testosterone effects on endogenous and somatocrinin-induced growth hormone release in intact and castrated male pigs. | growth hormone (gh) release is influenced mainly by two hypothalamic factors, growth hormone-releasing factor (grf) and somatostatin and is modulated by other hormones such as gonadal steroids. the objective of this study was to determine if castration (ca) and exogenous testosterone (te) affect endogenous and grf-induced gh release. purebred yorkshire male pigs (n = 32) were assigned to one of the following treatments: t1:ca; t2:ca +/- te; t3: intact (in); t4: in +/- te, in a 2 x 2 factorial de ... | 1989 | 2492917 |
| age-related differences in the spontaneous and thyrotropin-releasing hormone-stimulated release of prolactin and thyrotropin in ovariectomized rats. | effect of estradiol on the spontaneous and thyrotropin-releasing hormone (trh)-stimulated release of prolactin (prl) and thyrotropin (tsh) in young and aged ovariectomized (ovx) rats was investigated. old (22-26 months) and young (3 months) female rats were ovx 3 weeks before use. they were injected subcutaneously with estradiol benzoate (eb, 25 micrograms/kg) or sesame oil for 3 days and were catheterized via the right jugular vein. twenty hours after the last administration of eb, rats were in ... | 1989 | 2505153 |
| effect of neonatal androgenization on the testosterone feedback sensitivity in adult rats in two lighting conditions. | neonatally androgenized and intact adult male wistar rats received daily, during 1 week, either testosterone propionate or sesame oil injections in periodic or constant light. serum and pituitary gonadotropins and hypothalamic lhrh were measured. in periodic light, neonatal androgenization did not change the serum concentration or pituitary contents of gonadotropins, or the hypothalamic content of lhrh. testosterone injections decreased serum concentration and pituitary content of gonadotropin o ... | 1989 | 2515145 |
| [studies on the pressor mechanism of 19-hydroxyandrostenedione]. | in the present study, the pressor activity of 19-hydroxyandrostenedione (19-oh-ad) (which is a kind of androgen) and the presence or absence of the possibility of its role as an amplifier of mineralocorticoid were investigated. 34 wistar rats of 8 weeks of age were used as the experimental subjects. the rats were divided into 3 groups, the control group (n = 12), 19-oh-ad group (n = 12) and doca group (n = 10). the control group was given 0.2 ml of sesame oil, the 19-oh-ad group was given 10 mg ... | 1989 | 2524410 |
| effect of short-term exposure of rats to dehydroepiandrosterone on the hepatic metabolism of dimethylnitrosamine. | the influence of short-term treatment with dehydroepiandrosterone (dhea), a naturally occurring adrenal steroid, on hepatic metabolism and macromolecular interactions of the hepatocarcinogen dimethylnitrosamine (ndma) was investigated in male sprague-dawley rats. liver weight, total tissue protein (p less than 0.05), microsomal and cytosolic proteins and cytochrome p-450 (p less than 0.001) were all significantly increased in rats treated orally with dhea (300 mg/kg body wt., suspended in 1.0 ml ... | 1989 | 2531577 |
| norgestimate increases pituitary and hypothalamic concentrations of immunoreactive beta-endorphin. | progesterone is a potent hormone acting on the female reproductive tract and influencing a series of other functions. recent studies revealed a correlation between progesterone and brain neurotransmitters and neuropeptides. our study evaluated the possible effect of norgestimate, a new progestin, on hypothalamic and pituitary beta-endorphin (b-ep) concentration in castrated female rats. ovariectomy was performed under ethyl ether anesthesia. treatment was started 3 weeks after surgery. norgestim ... | 1989 | 2533055 |
| effects of perinatal kepone exposure on sexual differentiation of the rat brain. | timed-pregnant sprague-dawley rats were injected intraperitonealy with kepone dissolved in sesame oil on alternate days beginning on day 18 of gestation and extending through day 7 of lactation with doses of 10 or 5 mg/kg. at 7 days of age the neurologic development of the pups was assessed using the following tests: day of eye opening, occurrence of auditory startle, righting response, reflex suspension, tactile forelimb-placing response, negative geotaxis, and open-field activity. at 70 days o ... | 1985 | 2581194 |
| 20 years on sesame street. | 2007 | 2633896 | |
| [effects of desensitization and immunologic changes in patients with allergic asthma]. | the allergic dermal tests were carried out in 122 patients who were treated from june 1987 to august 1988. the positive rates for mycomutacapitis, myco-root-black, dust mite and artemisia pollemo were 37.5%, 34.5%, 34.2% and 21.88% respectively in inhaled antigens used for skin test. the positive rates for sesame, peanut, allium and garlic were rather high in food antigens used for skin test. the serum ige and the total ige tested by ba-elisa and human basophil degranulation test (hbdt) were obs ... | 1989 | 2636057 |
| neuropeptide-y stimulation of luteinizing hormone-releasing hormone secretion from the median eminence in vitro by estrogen-dependent and extracellular ca2+-independent mechanisms. | the roles of estrogen and extracellular calcium (ca2+) in neuropeptide-y (npy)-stimulated lhrh release from median eminence (me) fragments in vitro were examined. ovariectomized (ovx) rats received one or several sc implants of silastic tubes containing estradiol benzoate (235 micrograms/ml sesame oil) or vehicle. plasma estrogen concentrations were similar to levels during the estrous cycle. these estrogen treatments were equally effective in reducing the elevated plasma levels of lh in vehicle ... | 1989 | 2651093 |
| serotonin stimulation of the period of in vitro lhrh release is estradiol dependent. | the neurotransmitter serotonin (5-ht) has well known effects on the release of luteinizing hormone (lh) which may be estrogen and photoperiod dependent. an in vitro superfusion system was used to assess the potential role of 5-ht and photoperiod in modulating the release of luteinizing hormone releasing hormone (lhrh) from the mediobasal-suprachiasmatic-preoptic area (mbh-poa-scn) in the ovariectomized (ovx) and ovx estradiol (e2) implanted rat model of lh release. regularly cycling female holtz ... | 1989 | 2653571 |
| transplacental estrogen responses in the fetal rat: increased uterine weight and ornithine decarboxylase activity. | the synthetic estrogens, diethylstilbestrol (des) and ethynylestradiol (ee2), are more potent than 17 beta-estradiol (e2) in inducing uterine weight gain in the neonatal rat, due to the binding of e2 to serum alpha-fetoprotein (afp). however, all three hormones are equipotent in inducing neonatal uterine ornithine decarboxylase (odc) activity. the present study assessed estrogen potency in fetal rats. pregnant cd rats were injected sc daily on gestation days (gd) 16-20 with des, ee2, or e2 in se ... | 1989 | 2727933 |
| comparative acute renal effects of three n-(3,5-dichlorophenyl)carboximide fungicides: n-(3,5-dichlorophenyl)succinimide, vinclozolin and iprodione. | a large number of carboximides have been synthesized, tested and, in some cases, marketed as agricultural fungicidal agents. one carboximide fungicide n-(3,5-dichlorophenyl)succinimide (ndps) proved to be both highly efficacious as a fungicide and a nephrotoxin. the purpose of this study was to compare the acute nephrotoxic potential of three n-(3,5-dichlorophenyl)carboximide fungicides [ndps, vinclozolin (vclz) and iprodione (ipdo)] to determine if nephrotoxic potential correlated with fungicid ... | 1989 | 2734805 |
| studies on in vitro degradation and in vivo digestion of a slow ammonia releasing urea product. | a slow ammonia releasing urea product (uromalt) has been produced by autoclaving and drying of germinated barley and urea. in vitro degradability of nitrogen (ivdn, raab et al., 1983) was in average 62 +/- 9% in 4 hours, compared to 76 +/- 8% with an autoclaved and dried mixture of urea and not-germinated barley. mixtures of urea with leucaena l. or azadarichta indica (neem cake) showed degradabilities of about 80 and 93%, respectively, when dried at 39 degrees c, but of 65% when dried at 100 de ... | 1989 | 2735818 |
| analysis, characterization, and purification: requirements for toxicological evaluation of 1,4-dithiane. | 1,4-dithiane is an organo-sulfur chemical associated with production and storage of munitions. toxicological evaluation of this chemical was scheduled in rats because of the paucity of such information. prerequisite for the evaluation was the development of gas chromatographic procedures using flame ionization detection to determine the purity of the test chemical and to certify the concentration and stability of the chemical in the dosage form, sesame oil. mass and nuclear magnetic resonance sp ... | 1989 | 2753931 |
| retinoic-acid-induced limb-reduction defects: perturbation of zones of programmed cell death as a pathogenetic mechanism. | pregnant c57bl/6j mice were treated with 100 mg/kg body weight of all-trans retinoic acid in sesame oil on day 11.0 of gestation. among the live fetuses harvested on day 18 of gestation, 100% had mesomelic defects of the limbs as determined by gross examination and skeletal staining. control fetuses treated with sesame oil had no observable limb malformations. some treated and control embryos were harvested 12 hr after treatment and examined for patterns of cell death by using the supravital sta ... | 2009 | 2772851 |
| influence of dietary protein and gut microflora on endogenous synthesis of nitrate and n-nitrosamines in the rat. | groups of four germ-free (gf) and conventional (cv) rats were given purified diets containing either 50 or 200 g lactalbumin/kg for 2 wk and their urinary excretion of nitrate was measured. urinary excretion of n-nitrosoproline was also measured in one of the three experiments. both gf and cv rats given the high-protein diet excreted significantly more nitrate and n-nitrosoproline than those given the low-protein diet. on both diets gf rats excreted more nitrate than their cv counterparts but n- ... | 1989 | 2777148 |
| renal and hepatic toxicity of n-arylsuccinimides in fischer 344 rats. | the role of aromaticity in the nephrotoxic potential of n-arylsuccinimides was studied in male fischer 344 rats. rats were administered a single intraperitoneal (i.p.) injection of an n-arylsuccinimide derivative (0.4 or 1.0 mmol/kg) or sesame oil (2.5 ml/kg), and the renal function monitored at 24 and 48 h. the parent compound in this series, n-phenylsuccinimide (nps), had previously been shown to induce only minimal renal effects, having no effect on urine volume, blood urea nitrogen concentra ... | 1989 | 2778255 |
| acute nephrotoxicity induced by n-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid in fischer 344 rats. | n-(3,5-dichlorophenyl)succinimide (ndps) induces nephrotoxicity via one or more metabolites which arise from oxidation of the succinimide ring. the purpose of this study was to examine the nephrotoxic potential of n-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid (3-ndhsa), a potential metabolite of ndps and a positional isomer of n-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-ndhsa), a known nephrotoxic metabolite of ndps. male fischer 344 rats were administered a single intraperitoneal injec ... | 1989 | 2781590 |
| short term effects of glucocorticoids upon hippocampal ultrastructure. | this study evaluated hippocampal cytoarchitecture in male sprague-dawley (225-250 g) rats treated with corticosterone (cort) and in unhandled, unstressed rats. cort-treated animals received 20 mg/kg cort in sesame oil/day x 3 days; each dose produces levels in the upper physiologic range, similar to those produced by major stressors. using quantitative electron microscopy, sections from regions ca3b, ca1, and dentate gyrus were examined. surface density and surface area of golgi and the number o ... | 1989 | 2792278 |
| impaired performance on odor-aversion testing following prenatal aspartame exposure in the guinea pig. | pregnant guinea pigs were administered aspartame (500 mg/kg) in sesame oil by gavage or sesame oil alone between the day of conception and parturition. a nontreated control group was also maintained. there were no statistically significant effects of the treatment on maternal weight gain, litter size, or birth weight of the pups. newborn pups were weighed daily and on day 15 were injected with either licl or saline and placed in a cage with vanilla odor for 30 min. twenty-four hr later the pups ... | 1989 | 2796897 |
| direct administration of testosterone increases rat tibial epiphyseal growth plate width. | local injection of hormones into the tibial epiphyseal growth plate offers a possible model to answer whether sex steroids can affect bone growth directly. to answer this question, we injected different doses of testosterone enanthate (4, 40, 120 and 400 micrograms/100 g of rat weight) once into the tibial epiphyseal growth plate of castrated 35-day-old male rats. the contralateral tibia was injected with sesame oil and served as control. all animals were sacrificed at age 42 days. tibias were r ... | 1989 | 2800918 |
| opiate receptor ontogeny in the rat medial preoptic area is androgen-dependent. | the relationship of opiate receptors in the medial preoptic area of the hypothalamus (mpoa) to the gonadal steroid hormone environment during development was assessed using regional densitometric analysis of [3h]naloxone binding in autoradiographs prepared using brain sections from 5-day-old male and female rats treated postnatally either with tamoxifen (0.5 mg/kg), flutamide (20 mg/kg), dihydrotestosterone (dht; 12.5 mg/kg), or sesame oil vehicle. tamoxifen, a specific estrogen receptor antagon ... | 1988 | 2850504 |
| neonatal exposure to delta 9-tetrahydrocannabinol enhances sexual responses in the adult male mouse. | from day 1 post partum to postnatal day 5, lactating female mice were given daily oral doses of 25 microliters sesame oil, 0.5 mg tetrahydro-6,6,9-trimethyl-3-pentyl-6h-dibenzo(b,d)pyran-1-ol (delta 9-tetrahydrocannabinol; thc)/kg or 50 mg thc/kg in 25 microliters oil. additionally, the pups were given 20 microliter oil, 10 micrograms testosterone or 20 micrograms testosterone in 20 microliter oil s.c. from days 1 to 5 of age. this regimen resulted in nine treatment groups. at 60 days of age, al ... | 1986 | 2876047 |
| intratesticular injection as a method to assess the potential toxicity of various agents and to study mechanisms of normal spermatogenesis. | to better understand, to optimize, and to validate the technique of intratesticular (i.t.) injection, several parameters related to i.t. injection were examined. volumes exceeding 50 microliters could be injected i.t.; however, testes frequently became excessively turgid and backflow of injected fluids occurred. thus, a volume of 50 microliters or less was deemed optimal for injection. to determine the rate of distribution of substances throughout the testis, trypan blue was injected i.t. near t ... | 1987 | 2906900 |
| uterine secretory alterations coincident with embryonic mortality in the gilt after exogenous estrogen administration. | sixteen crossbred gilts were assigned randomly to receive either an i.m. injection of sesame oil (control) or estrogen (e), 5 mg of estradiol valerate, on d 9 and 10 of pregnancy. gilts were unilaterally hysterectomized on either d 12 and 14 or 16 and 18. uterine horns were flushed with 20 ml of .9% sterile nacl solution to recover conceptus tissue. conceptuses and endometrial explants were cultured for 24 h with 100 microci [3h] leucine in 15 ml of minimum essential media. after dialysis, cultu ... | 1989 | 2925548 |
| effects of prenatal administration of mestranol and two progestins on testosterone synthesis and reproductive tract development in male rats. | the oestrogen mestranol (0, 0.01, 0.1 mg/kg body weight per day) and the progestins medroxyprogesterone-acetate and norethisterone (0, 2, 20 mg/kg body weight per day each) in sesame oil were intubated intragastrically daily during gestational days 14.5 through 19.5 to pregnant rats. males were studied as 20.5-day-old foetuses and 4-month-old adults for serum testosterone and lh concentrations, in vitro testosterone synthesis, anogenital distance (foetuses only) and testes, seminal vesicle and v ... | 1987 | 2958983 |
| genital tract abnormalities in female rats exposed to diethylstilbestrol in utero. | genital tract morphology in 14-month old female rats exposed prenatally to diethylstilbestrol (des) was analyzed as part of an examination of the effects of transplacental exposure to des on estrogen sensitive tissues. pregnant sprague-dawley rats were injected with sesame oil alone or with des in sesame oil on days 10 and 13 of gestation (total dose 1.2 micrograms des) or on days 15 and 18 (total dose 1.2 micrograms or 120 micrograms des). female offspring (9-15 per group) were sacrificed at 14 ... | 1987 | 2980383 |
| bronchiolo-alveolar carcinoma after inhalation of vegetable oil through a tracheal cannula. | ten cases of carcinoma of the lung, mostly alveolar cell carcinomata, arising in patients after continuous use of (mostly mineral) oils as nose drops or laxatives, have till now been reported in the literature. we describe another such case, a man who used sesame oil to lubricate his tracheal cannula. | 1985 | 2996921 |
| the influence of tetracosactide and adrenal steroids on renal kallikrein activity and urinary kallikrein excretion in rats. | the effect of adrenal steroids (mineralo- and glucocorticoids) as well as that of the adrenocorticotrophic peptide tetracosactide (beta 1-24 corticotropin) on the renal kallikrein activity and on the urinary kallikrein excretion of rats was investigated. after the animals had been adapted to metabolic cages, they were injected with deoxycorticosterone acetate (15 mg/kg day), corticosterone (40 mg/kg day), both steroids combined or the vehicle (sesame oil). additional groups of rats received tetr ... | 1985 | 2998396 |
| enhanced ovarian gonadotropin receptors in the testosterone-induced polycystic ovary in rats. | to establish the role of hormone receptors in patients with polycystic ovary (pco), pco rats were prepared by treating with testosterone propionate (tp). five-day old immature female rats were subcutaneously injected with 1.25 mg tp in sesame oil. they were then killed at the age of 12 weeks. the ovarian receptors for lh and fsh as well as serum hormone levels were investigated in pco rats and also in control rats at the various stages of the estrous cycle. the lh receptor binding in the tp-trea ... | 1986 | 3010503 |
| delta-9-tetrahydrocannabinol during pregnancy in the rat: i. differential effects on maternal nutrition, embryotoxicity, and growth in the offspring. | either 15 or 50 mg/kg of delta-9-tetrahydrocannabinol (thc) in sesame oil was administered by gastric intubation to gravid rats during the last two weeks of gestation. a pair-fed control group was administered the vehicle alone and allowed to eat and drink only the amount consumed by the 50 mg/kg group on the same gestation days. a nontreated control group was left undisturbed during pregnancy. all treated and control litters were fostered at birth to untreated dams. among the dams receiving 50 ... | 1987 | 3041192 |
| delta-9-tetrahydrocannabinol during pregnancy in the rat: ii. effects on ontogeny of locomotor activity and nipple attachment in the offspring. | either 15 or 50 mg/kg delta-9-tetrahydrocannabinol (thc) in sesame oil was administered by gastric intubation to gravid rats during the last two weeks of gestation. a pair-fed control group was administered the vehicle alone and allowed to eat and drink only the amount consumed by the 50 mg/kg group on the same gestation days. a nontreated control group was left undisturbed during pregnancy. all treated and control litters were fostered at birth to untreated dams. intact litters from the two thc ... | 1987 | 3041193 |
| [the g.e.r.u. retrospective study of 400 cases of urticaria]. | the authors report on a study with computerised results of 400 urticaria and/or angioedema cases, which were explored in single dermatology center (pr. j. sayag) by the members of geru. the study was managed with a computerised file and was processed with sesame software. the figures achieved are related to semilogic and paraclinical data and to etiological factors. | 2010 | 3041987 |
| human chorionic gonadotropin and luteinizing hormone-releasing hormone reverse the blockade of ovulation in pregnant mare's serum gonadotropin-primed immature rats by the anti-androgenic drug, hydroxyflutamide. | the present study was designed to examine mechanism(s) of the anti-ovulatory action of the anti-androgen, hydroxyflutamide (oh-f). prepubertal rats were treated with 4 iu pregnant mare's serum gonadotropin (pmsg) (day -2) to induce first estrus and ovulation. they received oh-f in sesame oil or oil alone at 08:00 and 20:00 h on day 0 (the day of proestrus) and ovulations were assessed on the morning of day 1. eighty-three percent of control animals ovulated with a mean of 7.7 +/- 1.1 corpora lut ... | 1988 | 3048618 |
| prostaglandin f2 alpha as the luteolysin in swine: vi. hormonal regulation of the movement of exogenous pgf2 alpha from the uterine lumen into the vasculature. | to test the endocrine-exocrine theory of maternal recognition of pregnancy in the pig 16 gilts were assigned randomly to a 2 x 2 factorial involving pretreatment with sesame oil (so) or estradiol valerate (5 mg; ev) injected on days 11 through 14 of the estrous cycle and an intrauterine injection of saline (5 ml; sa) or prostaglandin f2 alpha (50 micrograms; pgf) on day 14. peripheral blood samples were collected for 120 min postinjection and analyzed for 15-keto-13,14-dihydro-pgf2 alpha (pgfm). ... | 1986 | 3082379 |
| anticarcinogenic and hepatotoxic interactions between retinyl acetate and butylated hydroxytoluene in rats. | the natural retinoid, retinyl acetate (ra), and the phenolic antioxidant, butylated hydroxytoluene (bht), are both effective inhibitors of mammary carcinogenesis in rats. the present study was designed to determine if an increased inhibition of mammary carcinogenesis is obtained when ra and bht are administered in combination. at age 50 days (time 0), virgin, female sprague-dawley rats received a single intragastric instillation of 16 mg of 7,12-dimethylbenz(a)anthracene dissolved in 1 ml sesame ... | 1986 | 3093062 |
| stimulation of estradiol-17 beta secretion by 7,12-dimethylbenz (a) anthracene during mammary tumor induction in sprague-dawley rats. | testosterone, androstenedione, progesterone, 17-hydroxyprogesterone, estrone and estradiol-17 beta serum levels were measured at given times after dimethylbenz (a) anthracene (dmba) treatment of a sensitive rat strain sprague-dawley (s-d) and a resistant strain wistar (w). tumors appeared with a 100% incidence around the 14th to 15th estrous cycle after dmba treatment in in sprague-dawley rats. hormonal determinations were made, during the 5th or 6th estrous cycle after dmba treatment, in groups ... | 1987 | 3112469 |