Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| attenuation of endotoxin-induced oxidative stress and multiple organ injury by 3,4-methylenedioxyphenol in rats. | endotoxin is a potent inducer of lipid peroxidation (lpo), which is associated with the development of endotoxemia. 3,4-methylenedioxyphenol (sesamol) is one of the sesame oil lignans with a high anti-lpo effect. whether sesamol can attenuate endotoxin-induced lpo and multiple organ injury is unknown. after a dose response for sesamol in endotoxin-challenged rats was established, experiments were conducted to assess its effects on hydroxyl radical, peroxynitrite, and superoxide anion counts, act ... | 2006 | 16552364 |
| central adenosine signaling plays a key role in centrally mediated hypotension in conscious aortic barodenervated rats. | we tested the hypothesis that clonidine-evoked hypotension is dependent on central adenosinergic pathways. five groups of male, conscious, aortic baroreceptor-denervated (abd) rats received clonidine (10 microg/kg i.v.) 30 min after i.v. 1) saline, 2) theophylline (10 mg/kg), or 3) 8-(p-sulfophenyl)theophylline (8-spt) (2.5 mg/kg) or 1 h after i.p. 4) dipyridamole (5 mg/kg) or 5) an equal volume of sesame oil. blockade of central (theophylline) but not peripheral (8-spt) adenosine receptors abol ... | 2006 | 16595736 |
| sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: possible involvement of the metabolites in the antihypertensive effect of sesamin. | sesamin, a major lignan in sesame seeds and oil, has been known to lower blood pressure in several types of experimental hypertensive animals. a recent study demonstrated that sesamin metabolites had in vitro radical-scavenging activities. thus, we determined whether the antioxidative effect of sesamin metabolites modulate the vascular tone and contribute to the in vivo antihypertensive effect of sesamin. we used four demethylated sesamin metabolites: sc-1m (piperitol), sc-1 (demethylpiperitol), ... | 2006 | 16597711 |
| effect of bcl-2 overexpression in mice on ovotoxicity caused by 4-vinylcyclohexene. | the occupational chemical 4-vinylcyclohexene (vch) destroys small preantral ovarian follicles in mice following repeated daily dosing. the cell survival gene bcl-2 is thought to protect against follicular death during embryogenesis because primordial follicle numbers in newborn bcl-2 overexpressing (oe) mice are greater than in wild-type (wt) controls. thus, this study was designed to determine if overexpression of bcl-2 protects against vch-induced follicle loss during embryonic development. pr ... | 2006 | 16631218 |
| effect of estrogen on calcium-handling proteins, beta-adrenergic receptors, and function in rat heart. | regulation of cellular ca(2+) cycling is central to myocardial contractile function. loss of ca(2+) regulation is associated with cardiac dysfunction and pathology. estrogen has been shown to modify contractile function and to confer cardioprotection. therefore, we investigated the effect of estrogen on expression of rat heart myocardial ca(2+)-handling proteins and beta-adrenergic receptor (beta(1)-ar) and examined functional correlates. female rats were sham-operated (sham) or ovariectomized. ... | 2006 | 16647722 |
| bioavailability of seocalcitol ii: development and characterisation of self-microemulsifying drug delivery systems (smedds) for oral administration containing medium and long chain triglycerides. | by constructing ternary phase diagrams it was possible to identify two self-microemulsifying drug delivery systems (smedds) containing either medium chain triglycerides (mc-smedds) or long chain triglycerides (lc-smedds), with the same ratio between lipid, surfactant and co-surfactant. the smedds ended up having a composition of 25% lipid, 48% surfactant and 27% co-surfactant, mc-smedds: viscoleo, cremophor rh40, akoline mcm and lc-smedds: sesame oil, cremophor rh40, peceol. upon dilution with w ... | 2006 | 16650738 |
| efficiency and regulation of water transport in some woody and herbaceous species. | the efficiency with which plants transport water is related to the water potential differences required to drive water fluxes from the soil to the leaf. a comparative study of two woody and three herbaceous species (citrus sinensis l. cv. koethen, pyrus kawakami l., helianthus annuus l. cv. mammoth russian, capsicum frutescens l. cv. yolo wonder, and sesamum indicum l. cv. glauca) indicated contrasts in water transport efficiency. depression of leaf water potential in response to transpiration i ... | 1974 | 16658853 |
| growth, phosphate pools, and phosphate mobilization of salt-stressed sesame and pepper. | the growth and phosphate mobilization of control and salt-stressed sesame (sesamum indicum l.) and pepper (capsicum annuum l.) plants were examined to ascertain whether or not translocation limits growth of salt-stressed plants. plants were grown in a complete nutrient solution with and without excess salt. one-half of the control and salt-stressed plants were later transferred to phosphate-free culture solution ("-p" plants). measurements of growth and phosphate pools in leaves indicated that w ... | 1978 | 16660491 |
| photoinhibition at low temperature in chilling-sensitive and -resistant plants. | photoinhibition resulting from exposure at 7 degrees c to a moderate photon flux density (300 micromoles per square meter per second, 400-700 nanometers) for 20 hours was measured in leaves of annual crops differing widely in chilling tolerance. the incidence of photoinhibition, determined as the decrease in the ratio of induced to total chlorophyll fluorescence emission at 693 nanometers (f(v)/f(max)) measured at 77 kelvin, was not confined to chilling-sensitive species. the extent of photoinhi ... | 1989 | 16666971 |
| sesamol delays mortality and attenuates hepatic injury after cecal ligation and puncture in rats: role of oxidative stress. | sesame oil potently protects rats against sepsis, and sesamol appears to be the protective ingredient in sesame oil. the aims of the present study were to examine the effects of sesamol on mortality and reactive oxygen species-associated liver injury in wistar rats with cecal-ligation-and-puncture-induced sepsis (septic rats). after sepsis was induced, sesamol was administered every 6 h. the survival rate was determined during the ensuing 48 h. hepatic injury was assessed using blood biochemistr ... | 2006 | 16680019 |
| regulation of membrane-associated prostaglandin e2 synthase 1 in pregnant sheep intrauterine tissues by glucocorticoid and estradiol. | this study was designed to determine the regulatory effect of glucocorticoid and estradiol on expression of ovine intrauterine membrane-associated prostaglandin e(2) synthase 1 (mptges1) in late gestation and at labor. for gestational and labor groups, 16 pregnant ewes from 95-147 d gestational age (dga) and four pregnant ewes at spontaneous term labor were used. the fetal glucocorticoid group, 14 pregnant ewes at 123-125 dga with fetuses, was divided into the following groups: after sham adrena ... | 2006 | 16690805 |
| increased expression of peripheral benzodiazepine receptor (pbr) in dimethylbenz[a]anthracene-induced mammary tumors in rats. | expression of peripheral benzodiazepine receptors (pbr) has been found in every tissue examined; however, it is most abundant in steroid-producing tissues. although the primary function of pbr is the regulation of steroidogenesis, its existence in nonsteroidogenic tissues as well as in other cellular compartments including the nucleus suggests that there may be other roles for pbr. our laboratory reported earlier a significant increase of pbr density in the nucleus of dmba-induced malignant subm ... | 2006 | 16691503 |
| allergic and anaphylactic response to sesame seeds in mice: identification of ses i 3 and basic subunit of 11s globulins as allergens. | allergy to sesame seeds is an emerging food allergy of a serious nature due to a high risk of systemic anaphylaxis. although a mouse model to study sesame anaphylaxis is desirable, currently it is not available. here, using a transdermal exposure model system, we tested the hypothesis that sesame seed elicits il-4-associated ige antibody response with consequent clinical sensitization in mice. | 2006 | 16699288 |
| alcohol levels in chinese lactating mothers after consumption of alcoholic diet during postpartum "doing-the-month" ritual. | this study examined the effects of exposure to ethanol through cultural practices by lactating mothers. specifically, the pharmacokinetics of alcohol in chinese lactating mothers was investigated after they consumed chicken soup flavored with sesame oil and rice wine (cssr), a typically prescribed diet during the postpartum "doing-the-month" period. experimental findings were employed to estimate the potential ethanol dose to neonates and determine associated health risks. twenty-three lactating ... | 2005 | 16713502 |
| antihypertensive effect of angiotensin i-converting enzyme inhibitory peptides from a sesame protein hydrolysate in spontaneously hypertensive rats. | sesame peptide powder (spp) exhibited angiotensin i-converting enzyme (ace) inhibitory activity, and significantly and temporarily decreased the systolic blood pressure (sbp) in spontaneously hypertensive rats (shrs) by a single administration (1 and 10 mg/kg). six peptide ace inhibitors were isolated and identified from spp. the representative peptides, leu-val-tyr, leu-gln-pro and leu-lys-tyr, could competitively inhibit ace activity at respective ki values of 0.92 microm, 0.50 microm, and 0.4 ... | 2006 | 16717411 |
| continuous enzymatic transesterification of sesame oil and a fully hydrogenated fat: effects of reaction conditions on product characteristics. | an immobilized lipase from thermomyces lanuginosus (tl im) was employed to mediate the continuous transesterification of sesame oil and fully hydrogenated soybean oil (fhsbo) in a packed-bed reactor operating at 70 degrees c. reactions between sesame oil (rich in lll (15.97%), lol (31.56%), and olo (21.15%) [l = linoleic; o = oleic]) and the fully hydrogenated fat ((73.7% sss, 26.3% sps) [s = stearic; p = palmitic]) produced semi-solid fats. these products are complex mixtures of triacylglycerol ... | 2006 | 16718681 |
| phytase production by thermophilic mold sporotrichum thermophile in solid-state fermentation and its application in dephytinization of sesame oil cake. | the phytase production by sporotrichum thermophile tlr50 was recorded on all the commonly used animal feed ingredients tested to varying degrees in solid-state fermentation. enzyme production increased to 180 u/g of dry moldy residue (dmr) in sesame oil cake at 120 h and 45 degrees c at the initial substrate-to-moisture ratio of 1:2.5 and aw of 0.95. supplementation of sesame oil cake with glucose and ammonium sulfate further enhanced phytase titer (282 u/g of dmr). an overall 76% enhancement in ... | 2006 | 16720904 |
| synchronization of estrus in beef cows and heifers with prostaglandin f(2alpha) and estradiol benzoate. | an experiment was conducted to study an estrous synchronization regimen that involved the use of prostaglandin f(2alpha) (pgf(2alpha)) alone or in combination with estradiol benzoate (eb) and appointment breeding. fifty-three registered angus yearling heifers and 167 registered angus cows (3 to 9 yr of age) were given two injections of pgf(2alpha) 11 d apart. forty-eight hours after the second injection of pgf(2alpha') a random sample consisting of 117 cows and heifers was injected with eb in se ... | 1987 | 16726310 |
| the use of epostane, a 3(beta)-hydroxysteroid dehydrogenase delta 4-5 isomerase enzyme inhibitor, in oil suspension as a mismating agent in the dog. | administration of epostane as a single subcutaneous injection in sesame oil prevented or terminated pregnancy in bred beagle bitches (p = 0.002). doses of 15 and 20 mg/kg prevented or terminated pregnancy in all of 14 bred beagle bitches studied but demonstrated a high rate of serious abscess formation at the injection site. a dose of 10 mg/kg was partially effective in 3 of 12 subjects whelping live pups, and a dose of 2.5 mg/kg was completely ineffective in 12 of 12 subjects whelping live pups ... | 1988 | 16726492 |
| effect of treatment with estradiol valerate on endocrine changes and ovarian follicle populations in dairy cows. | a linear-array ultrasound instrument was used to monitor the dynamics of follicular cyst formation following estradiol valerate (ev) administration in postpartum dairy cattle. twelve cyclic cows were given two intramuscular (i.m.) injections of prostaglandin and f(2alpha) (pgf(2alpha)) 12 d apart to synchronize estrus. on day 16 (day 0 = day of estrus) six cows received 10 mg of ev in 1 ml sesame oil; the remaining six cows were treated with 1 ml sesame oil. the ovaries of all cows were scanned ... | 1990 | 16726741 |
| effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause. | repeated daily dosing with 4-vinylcyclohexene diepoxide (vcd) causes gradual ovarian failure in mice. as a result, the animal undergoes ovarian failure, but retains residual ovarian tissue. the purpose of this study was to use a mouse model to regulate the induction of a period analogous to perimenopause in women. | 2006 | 16735946 |
| finasteride delays the onset of maternal behavior in primigravid rats. | the inhibitory actions of progesterone on maternal behavior may be due to its metabolite, allopregnanolone. allopregnanolone has been shown to mediate some cognitive, anxiolytic and sex behavior actions of progesterone. the objectives of the present study were to determine: first, if the administration of finasteride, a 5 alpha-reductase inhibitor, will stimulate fast-latency maternal behavior in primigravid rats and, second, to assess whether finasteride increases anxiety-like behaviors and alt ... | 2006 | 16750839 |
| correlation of hsp110 expression with caspase-3 and -9 during apoptosis induced by in vivo embryonic exposition to retinoic acid or irradiation in early mouse craniofacial development. | to analyze the expression and role of three proteins (hsp110, caspase-3 and caspase-9) during craniofacial development. | 2006 | 16764683 |
| high post-partum levels of corticosterone given to dams influence postnatal hippocampal cell proliferation and behavior of offspring: a model of post-partum stress and possible depression. | post-partum stress and depression (ppd) have a significant effect on child development and behavior. depression is associated with hypercortisolism in humans, and the fluctuating levels of hormones, including corticosterone, during pregnancy and the post-partum, may contribute to ppd. the present study was developed to investigate the effects of high-level corticosterone (cort) post-partum in the mother on postnatal neurogenesis and behavior in the offspring. sprague-dawley dams were treated wit ... | 2006 | 16780843 |
| occurrence of aflatoxins, ochratoxin a, and fumonisins in retail foods in japan. | we conducted a survey of aflatoxin b1, b2, g1, and g2, ochratoxin a, and fumonisin b1, b2, and b3 contamination in various foods on the retail market in japan in 2004 and 2005. the mycotoxins were analyzed by high-performance liquid chromatography, liquid chromatography-mass spectrometry, or high-performance thin-layer chromatography. aflatoxins were detected in 10 of 21 peanut butter samples; the highest concentration of aflatoxin b1 was 2.59 microg/kg. aflatoxin contamination was not found in ... | 2006 | 16786858 |
| methoxychlor induces atresia of antral follicles in eralpha-overexpressing mice. | methoxychlor (mxc) is a pesticide that is known to bind to estrogen receptor alpha (eralpha) and to induce atresia of antral ovarian follicles. although studies have shown that mxc is toxic to the ovary, we hypothesize that perturbation to the estrogen-signaling system (i.e., increase or decrease in estrogen sensitivity) might alter ovarian responsiveness to mxc. thus, we examined whether eralpha overexpression alters the ability of mxc to increase follicle atresia. to do so, we employed a trans ... | 2006 | 16787999 |
| estrogen-induced region specific decrease in the density of 5-bromo-2-deoxyuridine-labeled cells in the olfactory bulb of adult female rats. | effects of chronic estrogen treatment on the survival rate of newly integrated interneurons were studied in the olfactory bulb of adult (250-300 g) female rats. ovariectomized rats received 17-beta estradiol dissolved in sesame oil (i.p., 100 microg/100 g body weight [b.w.]) during six consecutive days, and on day 6 they were also injected with the mitotic marker 5-bromo-2-deoxyuridine (brdu, i.p., 50 mg/kg b.w.) in every 2 hours during 8 hours. after 21 days of survival animals were killed and ... | 2006 | 16814932 |
| characteristics of structured lipid prepared by lipase-catalyzed acidolysis of roasted sesame oil and caprylic acid in a bench-scale continuous packed bed reactor. | structured lipid (sl) was prepared from roasted sesame oil and caprylic acid (ca) by rhizomucor miehei lipase-catalyzed acidolysis in a bench-scale continuous packed bed reactor. total incorporation and acyl migration of ca in the sl were 42.5 and 3.1 mol %, respectively, and the half-life of the lipase was 19.2 days. the sl displayed different physical and chemical properties, less saturated dark brown color, lower viscosity, lower melting and crystallization temperature ranges, higher melting ... | 2006 | 16819927 |
| effect of dietary sesame oil as antioxidant on brain hippocampus of rat in focal cerebral ischemia. | oxidative stress may be regarded as an imbalance between free radical production and opposing antioxidant defenses. free radical oxidative stress is implicated in rat cerebral ischemia and naturaceutical antioxidants are dietary supplements that have been reported to have neuroprotective activity. many studies have reported dietary sesame oil (so) as an effective antioxidant. in the present study the neuroprotective effect of dietary so was evaluated against middle cerebral artery occlusion (mca ... | 2006 | 16822528 |
| prostaglandin f2alpha upregulates uterine immune defenses in the presence of the immunosuppressive steroid progesterone. | uterine infections often develop in some livestock species during the first luteal phase postpartum. exogenous prostaglandin f(2alpha) (pgf(2alpha)) induces luteolysis, reduces progesterone, and enables the uterus to resolve infections. however, the effects of pgf(2alpha) on luteal function and on immune functions are confounded. these effects must be disentangled to determine whether alternatives to antibiotic treatments can be successfully developed. | 2006 | 16836612 |
| inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced nf-kappab activation and target gene expression in cultured rat astrocytes. | the inflammatory reaction plays an important role in the pathogenesis of the neurodegenerative disorder including alzheimer's disease (ad). sesame lignan compounds such as sesaminol glucosides (sg) exhibit a range of pharmacological activities including anti-oxidative and anti-inflammatory action. in this study, we tried to elucidate possible effects of sg on lipopolysaccharide (lps)-induced inflammatory reaction and its underlying mechanism in cultured astrocytes. sg (10-100 microg/ml) inhibite ... | 2006 | 16842873 |
| two separate outbreaks of salmonella enteritidis phage type 14b food poisoning linked to the consumption of the same type of frozen food. | to ascertain, using a combination of epidemiological, environmental and microbiological methods of investigation, a possible link between two outbreaks of salmonella food poisoning. | 2006 | 16879847 |
| methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. | methoxychlor (mxc) is an organochlorine pesticide that reduces fertility in female rodents by causing ovarian atrophy, persistent estrous cyclicity, and antral follicle atresia (apoptotic cell death). oxidative damage resulting from reactive oxygen species (ros) generation has been demonstrated to lead to toxicant-induced cell death. thus, this work tested the hypothesis that mxc causes oxidative damage to the mouse ovary and affects mitochondrial respiration in a manner that stimulates ros prod ... | 2006 | 16890261 |
| chronic corticosterone-induced deterioration in rat behaviour is not paralleled by changes in hippocampal nf-kappab-activation. | we investigated whether long-lasting stress induced by chronic glucocorticoid (gc) exposure affects activation of brain nf-kappab and whether these changes are related to functional deterioration and structural changes in the rat hippocampus. psychometric investigations were conducted using a holeboard test system in 28 one-year-old male wistar rats. thereafter, rats were divided into three groups for daily administration of 10 mg corticosterone (treatment) or sesame oil (placebo = sham control ... | 2006 | 16895833 |
| activation of alpha2-adrenoceptors in the trigeminal region produces sex-specific modulation of nociception in the rat. | sex-related differences in the sensitivity to pain and in the response to analgesics have been reported including higher perceptual responses to experimentally induced pain and the higher prevalence of many pain syndromes in women compared with men. this study examines whether alpha2-adrenoceptor-mediated antinociceptive effects are reduced by estrogen which could account for the sex-related differences in pain perception and modulation. clonidine, an alpha2-adrenoceptor agonist, has been shown ... | 2006 | 16934408 |
| beneficial effects of soy protein in the initiation and progression against dimethylbenz [a] anthracene-induced breast tumors in female rats. | this study was to demonstrate by histological grading whether soy protein protects against dimethylbenz[a]anthracene (dmba) -induced breast tumors in female rats. at 25 days of age, rats were fed diets containing either casein or soy protein. after 25 days on diets, a single dose of dmba in sesame oil (80 mg/kg) was administered by gavage. all tumors were detected by palpation. the number of tumors per rat was less in soy group than that in casein group at any time point up to 122 days after dmb ... | 2006 | 16941229 |
| formulation modifications of pd 0313052, a direct factor xa inhibitor, alter pharmacokinetics and pharma-codynamics following subcutaneous administration to rabbits. | pd 0313052 is a potent, direct factor xa (fxa) inhibitor (ki = 0.33 nm) and its antithrombotic effect has been previously demonstrated in several animal models, via intravenous (iv) administration. in the present study, we evaluated four different subcutaneous (sc) formulations to test the feasibility of developing pd 0313052 as a subcutaneous agent. | 2006 | 16959183 |
| estrogen modulates place learning through estrogen receptors in the hippocampus. | moderate elevations in circulating estradiol enhance learning in tasks that tap place learning strategies such as those requiring the use of extramaze cues. use of place learning strategies is particularly impaired by damage to the hippocampus, a structure shown to be sensitive to estrogen treatments. we have shown that direct estrogen infusions into the dorsal hippocampus, and not the dorsolateral striatum, enhance place learning, suggesting that the hippocampus may be an important modulatory s ... | 2006 | 16979357 |
| reproductive toxicity of trenbolone acetate in embryonically exposed japanese quail. | this study was conducted to assess the effects of a one time embryonic exposure to trenbolone acetate on reproductive development and function in japanese quail (coturnix japonica). embryos were exposed to either 0.05, 0.5, 5, or 50microg trenbolone or a sesame oil vehicle control at embryonic day 4. onset of puberty, gonadal histopathology, sperm motility, cloacal gland size, and male copulatory behavior were assessed in adults. trenbolone delayed onset of puberty in males, inhibited cloacal gl ... | 2007 | 16989888 |
| rise of testosterone, nortestosterone, and 17beta-estradiol concentrations in peripheral blood plasma of pigs after sublingual application in vivo. | application of endogenous anabolic steroids to meat producing animals is not allowed in the eu. in other countries application is practised due to a low oral activity based on an efficient first liver passage. this contrasts with pharmacological investigations where steroids were readily absorbed by the buccal and sublingual mucosa using absorption enhancers. an in vivo study was performed to clarify possible absorption after sublingual applications of one milligram portions of either testostero ... | 2007 | 17010491 |
| dissecting drug and vehicle metabolic effects in rats by a metabonomic approach. | a combined application of high resolution (1)h nmr spectroscopy and multivariate statistical techniques focused on establishing a consistent statistical approach to metabonomic studies was tested. the data reduction, which is preliminary to the application of multivariate analysis to nmr spectra, was carried out by means of two complementary methods: pure pattern recognition (pr) and assigned signal analysis (asa). the simultaneous use of both approaches allowed us to obtain additional informati ... | 2007 | 17011038 |
| neuropeptide glutamic acid-isoleucine may induce luteinizing hormone secretion via multiple pathways. | neuropeptide glutamic acid-isoleucine (nei) is a 14-amino acid peptide processed from prepro-melanin-concentrating hormone (ppmch). in males, the localization of nei is almost identical to that of mch, the cell bodies of both being located primarily in the lateral hypothalamic area and zona incerta, projecting fibers throughout the brain. although mch has been widely studied, the role that nei plays in brain circuitry has been poorly investigated. recently, we showed that intracerebroventricular ... | 2006 | 17016031 |
| effects of p-nonylphenol and 4-tert-octylphenol on the anterior pituitary functions in adult ovariectomized rats. | p-nonylphenol (np) and 4-tert-octylphenol (op) are known to mimic the action of estrogens as endocrine disruptors. however, their acute effects on the pituitary and the hypothalamus functions in vivo have been uncertain. we therefore determined their effects on the anterior pituitary, in particular, gonadotropin secretion. two weeks after ovariectomy, the rats were given a subcutaneous injection of 10 mg np, 10 mg op, 10 mg bisphenol a, 1 microg 17beta-estradiol, or sesame oil alone as control. ... | 2006 | 17033158 |
| effect of sesamin on serum cholesterol and triglycerides levels in ldl receptor-deficient mice. | sesamin, a major lignan from sesame seeds has been associated with cholesterol reduction in previous reports, but recent studies suggested differences in the response to sesamin intake depending on the model studied as well as the nature of the sesamin preparation used. | 2006 | 17039285 |
| bisphenol a induces transforming growth factor-beta3 mrna in the preoptic area: a cdna expression array and northern blot study. | to gain better understanding of the effects of bisphenol a (bpa) in the adult brain, a cdna expression array was used to screen possible candidates for bpa-inducible genes in the medial preoptic area (mpoa). adult ovariectomized rats were given a subcutaneous injection of 10 mg bpa or sesame oil alone as a control. twenty-four hours after the injection, the mpoas were dissected and total rnas were extracted. when expression levels of cdnas derived from pooled samples were compared to controls, t ... | 2007 | 17052851 |
| uptake of 2s albumin allergens, ber e 1 and ses i 1, across human intestinal epithelial caco-2 cell monolayers. | we have investigated the absorption rates of two purified major allergen 2s albumins, ber e 1 from brazil nuts (bertholletia excelsa humb. & bonpl.) and ses i 1 from white sesame seeds (sesamum indicum l.), across human intestinal epithelial caco-2 cell monolayers following gastrointestinal digestion in vitro. the transport from apical to basolateral side in cell monolayers was evaluated by rp-hplc-uv and indirect competitive elisa methods, being confirmed by western-blotting analysis. significa ... | 2006 | 17061844 |
| localized lesions of arcopallium intermedium of the lateral forebrain caused a handling-cost aversion in the domestic chick performing a binary choice task. | behavioral effects of handling cost (time and/or energetic cost for food consumption) on choice were examined using domestic chicks trained in operant task reinforced by delayed food rewards. when scattered sesame was delivered in more demanding conditions, a colored cue bead associated with six grains ('large' and 'costly' reward) was chosen progressively less frequently against another bead associated with one grain ('small' and 'not costly' reward). the choice thus proved to be highly sensiti ... | 2006 | 17074052 |
| differential disruption of nuclear volume and neuronal phenotype in the preoptic area by neonatal exposure to genistein and bisphenol-a. | changes in the volumes of sexually dimorphic brain nuclei are often used as a biomarker for developmental disruption by endocrine-active compounds (eacs). however, these gross, morphological analyses do not reliably predict disruption of cell phenotype or neuronal function. in the present experiments, we used a more comprehensive approach to assess whether postnatal exposure to the eacs genistein (gen) or bisphenol-a (bis) affected the development of two sexually dimorphic brain regions in male ... | 2007 | 17109964 |
| lasting changes in neuronal activation patterns in select forebrain regions of aggressive, adolescent anabolic/androgenic steroid-treated hamsters. | repeated exposure to anabolic/androgenic steroids (aas) during adolescence stimulates high levels of offensive aggression in syrian hamsters. the current study investigated whether adolescent aas exposure activated neurons in areas of hamster forebrain implicated in aggressive behavior by examining the expression of fos, i.e., the protein product of the immediate early gene c-fos shown to be a reliably sensitive marker of neuronal activation. adolescent aas-treated hamsters and sesame oil-treate ... | 2007 | 17113655 |
| sesame oil attenuates acute iron-induced lipid peroxidation-associated hepatic damage in mice. | acute iron intoxication from the accidental ingestion of iron-containing preparations is one important cause of death in children. the aim of this study was to investigate the protective effect of sesame oil on acute iron-induced lipid peroxidation (lpo) and hepatic injury in mice. acute iron intoxication was induced by giving ferric nitrilotriacetate to mice. hepatic function was assessed using blood biochemistry. free radicals were determined using a high-performance chemiluminescence analyzer ... | 2006 | 17117140 |
| buckwheat anaphylaxis: an unusual allergen in taiwan. | ige-mediated hypersensitivity to buckwheat is common in korea, japan, and some other asian countries. however, buckwheat is not a common allergen in taiwan. we report a woman with asthma who had anaphylactic shock, generalized urticaria, and an acute exacerbation of asthma five minutes after ingesting buckwheat. the patient underwent skin prick and pharmacia cap testing (uppsala, sweden) for specific ige to buckwheat, white sesame and soybean as well as other common allergens in taiwan including ... | 2006 | 17136883 |
| effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats. | there are sex differences in nociceptive behavior induced by formalin in rats. to determine whether these sex differences are the result of the sexual differentiation of the brain, that is masculinization and defeminization [a.p. arnold, r.a. gorski, gonadal steroid induction of structural sex differences in the central nervous system, annu. rev. neurosci. 7 (1984) 413-442; m.m. mccarthy, a.t.m. konkle, when is a sex difference not a sex difference? front neuroendocrinol. 26 (2005) 85-102], some ... | 2007 | 17145136 |
| alpha-tocopheryl succinate (alpha-tos) modulates human prostate lncap xenograft growth and gene expression in balb/c nude mice fed two levels of dietary soybean oil. | malignancy of the prostate constitutes a leading cause of cancer-related deaths in america and europe. alpha-tocopheryl succinate (alpha-tos) has been shown to inhibit human prostate cancer growth in vitro, via several mechanisms, including inhibiting prostate-specific antigen (psa) and vascular endothelial growth factor (vegf) expressions. the route of alpha-tos administration has a profound effect on its antitumor activity, and few studies have investigated its effects on prostate cancer growt ... | 2007 | 17180484 |
| reduction in 7,12-dimethylbenz[a]anthracene-induced hepatic cytochrome-p450 1a1 expression following soy consumption in female rats is mediated by degradation of the aryl hydrocarbon receptor. | consumption of a soy diet has been found to reduce cancer incidence in animals and is associated with reduced cancer risk in humans. in this study, the effect of consuming soy protein isolate (spi) on the aryl hydrocarbon receptor (ahr)-mediated signaling pathway was investigated. female sprague-dawley rats were fed ain-93g diets with (+) or without (-) spi-bound phytochemicals or casein (cas) protein and gavaged orally with 7,12-dimethylbenz[a]anthracene (dmba) or sesame oil. we found reduced ( ... | 2007 | 17182795 |
| inhibition of atherosclerosis in low-density lipoprotein receptor-negative mice by sesame oil. | diet has profound effects on the development of atherosclerosis. fatty acid composition, antioxidants, and other components such as lignans have major effects on the atherosclerotic process. sesame oil has both mono- and polyunsaturated fatty acid constituents in equal proportions. in addition, it also has high levels of numerous antioxidants and inducers of peroxisome proliferator-activated receptor. the objective of this study was to determine the anti-atherosclerotic effects of sesame oil. in ... | 2006 | 17201634 |
| comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. | effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats. rats were fed either a lignan-free diet, a diet containing 0.6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1.4 g/kg) and sesamolin (0.6 g/kg) for 10 d. sesamin and sesamolin dose-dependently increased the activity and mrna abundance of various enzymes involved in hepatic fatty acid oxidation. the increase was much greater with sesamolin than with sesamin. thes ... | 2007 | 17217563 |
| sesame oil attenuates cisplatin-induced hepatic and renal injuries by inhibiting nitric oxide-associated lipid peroxidation in mice. | although cisplatin (cis-diamminedichloroplatinum) is an effective drug for the treatment of several solid tumors and has been used therapeutically for decades, several cisplatin-induced side effects have limited its therapeutic dosage in clinical studies. our aim was to examine the effect of sesame oil on cisplatin-induced hepatic and renal injuries in mice (8-week-old female spf c57bl/6) given subcutaneous cisplatin (0, 5, 10, or 20 mg/kg). hepatic and renal functions, lipid peroxidation (lpo) ... | 2007 | 17224796 |
| effects of early embryonic exposure to genistein on male copulatory behavior and vasotocin system of japanese quail. | genistein is a phytoestrogen, particularly abundant in soybeans that can bind estrogen receptors and sex hormone binding proteins, exerting both estrogenic and antiestrogenic activity. in this study we used the japanese quail embryo as a test end-point to investigate the effects of early embryonic exposure to genistein on male copulatory behavior and on vasotocin parvocellular system. both differentiate by the organizational effects of estradiol during development and may therefore represent an ... | 2007 | 17274996 |
| antioxidant protection of edible oils. | the ability of different cooking oils to withstand oxidation was investigated in relation to their native antioxidant capacity [measured as the ferric reducing/antioxidant power (frap) value]. the antiperoxidation effect of the presence of the chinese herbs, du-zhong (cortex eucommia ulmoides) and ginseng (panax ginseng c.a. mayer) in corn oil was also investigated over 26 days' storage at 55 degrees c. results showed that sesame oil had the highest frap value (803 microm), followed by canola oi ... | 2007 | 17285359 |
| silicone rubber nipples: effects of sesame-oil extract on reproduction in mice. | the authors investigated a type of silicone rubber (sr) nipple for toxicity, caused by chemical migrants, on reproduction and pregnancy outcomes. they followed an extraction method (set forth in the 20th revised edition of the united states pharmacopeia) in which sesame oil was a vehicle. they prepared the extract daily and administered it orally (50 ml/kg of body weight) into pregnant swiss albino mice from gestation day 0 until delivery. they gave a control group of mice the pure vehicle that ... | 2005 | 17290848 |
| sesame oil protects against lead-plus-lipopolysaccharide-induced acute hepatic injury. | lead (pb) increases lipopolysaccharide (lps)-induced tumor necrosis factor alpha, which causes liver damage. in this study, we investigated the effect of sesame oil on pb-plus-lps (pb + lps)-induced acute liver damage in mice. mice were given sesame oil (8 ml/kg orally) just after pb acetate (10 mmol/kg i.p.) plus lps (5 mg/kg i.p.). aspartate aminotransferase, alanine aminotransferase, tumor necrosis factor-alpha, interleukin-1beta, nitric oxide, and inducible nitric oxide synthase levels were ... | 2007 | 17304116 |
| sesame-hsqc for simultaneous measurement of nh and ch scalar and residual dipolar couplings. | we present a novel pulse sequence, sesame-hsqc, for the simultaneous measurement of several nh and ch scalar and residual dipolar couplings in double labeled proteins. the proposed spin-state selective all multiplicity edited (sesame)-hsqc combines gradient selected and sensitivity enhanced (15)n- and constant-time (13)c-hsqc experiments with the recently introduced spin-state selective method (nolis et al., j. magn. reson. 180 (2006) 39-50) for measuring couplings simultaneously at amide and al ... | 2007 | 17310475 |
| a new method to measure the semantic similarity of go terms. | although controlled biochemical or biological vocabularies, such as gene ontology (go) (http://www.geneontology.org), address the need for consistent descriptions of genes in different data sources, there is still no effective method to determine the functional similarities of genes based on gene annotation information from heterogeneous data sources. | 2007 | 17344234 |
| role of 17 beta-estradiol on type iv collagen fibers volumetric density in the basement membrane of bladder wall. | the authors quantified the type iv collagen fibers volumetric density in the basement membrane of bladder wall of ovariectomized rats with and without estradiol replacement. this study was conducted on 40 wistar rats (3 months old) randomly divided in 4 groups: group 1, remained intact (control); group 2, submitted to bilateral oophorectomy and daily replacement 4 weeks later of 17 beta-estradiol for 12 weeks; group 3, sham operated and daily replacement 4 weeks later of sesame oil for 12 weeks; ... | 2007 | 17347794 |
| comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. | to characterize the stability, pharmacokinetics and metabolism of analogs of gossypol, apogossypol and apogossypol hexaacetate to provide a basis for comparison. | 2008 | 17356822 |
| effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats. | previous studies have identified that progesterone may be neuroprotective following traumatic brain injury (tbi). however, most of these have utilized models of tbi that produce a focal lesion or a significant ischemic component, neither of which is necessarily present in diffuse tbi. the current study uses a model of diffuse tbi in rats to examine the effects of progesterone on morphological changes and functional outcome following tbi. male and ovariectomized female rats were subject to severe ... | 2007 | 17362936 |
| serotonin receptor involvement in effects of restraint on female rat lordosis behavior. | ovariectomized fischer (cdf-344) rats, with bilateral cannulae in the mediobasal hypothalamus (mbh) near the ventromedial nucleus of the hypothalamus (vmn), were used to test the hypothesis that serotonin receptors in the vmn contribute to the lordosis-inhibiting effects of mild restraint. rats were hormonally primed with 10 microg estradiol benzoate (eb) followed 48 h later with sesame seed oil. four to six hours later (during the dark portion of the light-dark cycle), rats were pretested for s ... | 2007 | 17368527 |
| quantitative nmr analysis of a sesamin catechol metabolite in human urine. | sesamin, the major sesame oil lignan, is recognized for its health-promoting effects, including the lowering of cholesterol and elevation of gamma-tocopherol in rats and humans. however, little is known about the absorption and metabolism of sesamin in humans. in this study, 6 healthy volunteers took a single dose of sesame oil (508 micromol sesamin) and their urine was collected for four 12-h periods. the urine samples were treated with beta-glucuronidase/sulphatase and extracted with chlorofor ... | 2007 | 17374658 |
| efficacy of some plant oils alone and/or combined with different insecticides on the cotton leaf-worm spodoptera littoralis (boisd.) (lepidoptera: noctuidae) in egypt. | the present work was conducted to evaluate the efficiency of two essential oils ((flax or "linseed" and sesame ), five volatile plant oils ( camphor, red basil, rose, menthol and clove ), four pesticides (methoxyfenozide; permethrin; profenofos and spinosad) and their mixtures on the cotton leaf-worm spodoptera littoralis (boisd.). this study was also devoted to minimize the usage of conventional insecticides, reduce the environmental pollution, and protect human-beings and domestic animals from ... | 2006 | 17385497 |
| advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. | this review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insects and in allergic skin disease that were reported primarily in the journal in 2006. advances in diagnosis include identification of food proteins to which ige binding is associated with severe reactions; elucidation of diagnostic relationships of skin prick test wheal size with outcomes of egg, tree nut, and sesame allergy; evaluation of the diagnostic utility of atopy pa ... | 2007 | 17412401 |
| repeated anabolic/androgenic steroid exposure during adolescence alters phosphate-activated glutaminase and glutamate receptor 1 (glur1) subunit immunoreactivity in hamster brain: correlation with offensive aggression. | male syrian hamsters (mesocricetus auratus) treated with moderately high doses (5.0mg/kg/day) of anabolic/androgenic steroids (aas) during adolescence (p27-p56) display highly escalated offensive aggression. the current study examined whether adolescent aas-exposure influenced the immunohistochemical localization of phosphate-activated glutaminase (pag), the rate-limiting enzyme in the synthesis of glutamate, a fast-acting neurotransmitter implicated in the modulation of aggression in various sp ... | 2007 | 17418431 |
| the sebhlh transcription factor mediates trans-activation of the sefad2 gene promoter through binding to e- and g-box elements. | microsomal oleic acid desaturase (fad2) catalyzes the first extra-plastidial desaturation in plants, converting oleic acid to linoleic acid, which is a major constituent in all cellular membranes as well as in seed storage oils. seed-specific fad2 (sefad2) produced 40% of linoleic acids in the total fatty acids of sesame (sesamum indicum) seeds. the expression of sefad2 transcripts was spatially and temporally controlled during seed development. to investigate the regulatory mechanism controllin ... | 2007 | 17420955 |
| hsp110, caspase-3 and -9 expression in physiological apoptosis and apoptosis induced by in vivo embryonic exposition to all-trans retinoic acid or irradiation during early mouse eye development. | apoptosis is an essential physiological process in embryonic development. in the developing eye of vertebrates, three periods of developmental apoptosis can be distinguished: early, intermediate and later. within the apoptosis pathway, caspases play a crucial role. it has also been shown that hsp110 may have a potential role in apoptosis. the aim of this research was to study the expression of hsp110, caspase-3 and -9 in physiological, retinoic- or irradiation-induced apoptosis during early eye ... | 2007 | 17451530 |
| suppression of ochratoxin biosynthesis by naturally occurring alkaloids. | the effects of four alkaloids on the biosynthesis of ochratoxin a (ota), ochratoxin b (otb) and citrinin were examined on four ota-producing aspergilli: aspergillus auricomus, a. sclerotiorum and two isolates of a. alliaceus. piperine and piperlongumine, natural alkaloids of piper longum, significantly inhibited ota production at 0.001% (w/v) for all aspergilli examined. piperine and piperlongumine affected the polyketide synthesis step of ota production and inhibited production of citrinin. cur ... | 2007 | 17454112 |
| activity of an essential oil derived from chenopodium ambrosioides on greenhouse insect pests. | this study involved both greenhouse and laboratory experiments evaluating the effect of an essential oil product (qrd 400) derived from chenopodium ambrosioides variety nr. ambrosioides l. (chenopodiaceae) on greenhouse insect pests that feed on different plant parts: citrus mealybug, planococcus citri (risso); longtailed mealybug, pseudococcus longispinus (targioni tozzetti); western flower thrips, frankliniella occidentalis (pergande), and fungus gnats (bradysia spp.). treatments were applied ... | 2007 | 17461071 |
| occurrence of "mammalian" lignans in plant and water sources. | enterolignans, also called "mammalian" lignans because they are formed in the intestine of mammals after ingestion of plant lignans, were identified for the first time in extracts of four tree species, i.e., in knot heartwood of the hardwood species fagus sylvatica and in knot or stem heartwood of the softwood species araucaria angustifolia, picea smithiana, and abies cilicia. they were also identified for the first time in grain extracts of cultivated plants, i.e., in 15 cereal species, in 3 nu ... | 2007 | 17497165 |
| isolation and characterization of a lipid-degrading bacterium and its application to lipid-containing wastewater treatment. | to construct an efficient lipid-containing wastewater treatment system, microorganisms that degrade lipids efficiently were isolated from various environmental sources. strain dw2-1 showed the highest rate of degradation of 1% (w/v) salad oil among the isolated strains. strain dw2-1 was identified as burkholderia sp. and designated burkholderia sp. dw2-1. the rate of degradation of salad oil, olive oil, sesame oil, and beef tallow by strain dw2-1 were 96.7%, 92.3%, 90.1% and 77.4%, respectively, ... | 2007 | 17502273 |
| estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. | steroid modulation of cognitive function has focused on estrogen (e(2)), but progestins naturally co-vary with e(2) and may also influence cognitive performance. spatial performance in the object placement task over endogenous hormonal states in which e(2) and progestins vary, and when e(2) and/or progestins were administered, was examined. experiment 1: rats in proestrus or estrus had significantly better performance in the object placement task than did diestrus rats. experiment 2: rats in the ... | 2007 | 17507257 |
| effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys. | the ovarian steroid hormone, estradiol, enhances the reinforcing and locomotor activating effects of cocaine in rodents under some conditions. the present study evaluated the acute effects of estradiol benzoate (e(2)beta) on cocaine self-administration and cocaine discrimination in female rhesus monkeys. cocaine self-administration (0.10 mg/kg/inj., i.v.) was maintained on a fixed-ratio (fr) 30 schedule of reinforcement, and monkeys had access to cocaine during one 2-h session each day. e(2)beta ... | 2008 | 17507915 |
| characterization of the cultivable microbiota of sprouts and their potential for application as protective cultures. | the microbiota of ten seeds and ready-to-eat sprouts produced thereof was characterized by bacteriological culture and denaturing gradient gel electrophoresis (dgge) of amplified dna fragments of the 16s rrna gene. the predominant bacterial biota of hydroponically grown sprouts mainly consisted of enterobacteria, pseudomonades and lactic acid bacteria (lab). for adzuki, alfalfa, mung bean, radish, sesame and wheat, the ratio of these bacterial groups changed strongly in the course of germination ... | 2007 | 17512686 |
| ses i 6, the sesame 11s globulin, can activate basophils and shows cross-reactivity with walnut in vitro. | sesame allergy is increasingly being reported, and multi-sensitization to peanut and tree nuts has been described. the clinical relevance and cross-reactivity of many sesame proteins, such as ses i 6, are unknown. | 2007 | 17517107 |
| interaction of sesame seed and tamoxifen on tumor growth and bone health in athymic mice. | some premenopausal breast cancer patients use phytoestrogen-rich soy and flaxseed to alleviate side effects induced by drugs such as tamoxifen (tam). lignan-rich flaxseed protects against breast cancer and increases the effectiveness of tam. this study determined the interactive effects of lignan-rich sesame seed (ss) and tam on estrogen-responsive mcf-7 breast tumor growth and bone health in ovariectomized athymic mice under premenopausal-simulated conditions. ovariectomized mice with an estrog ... | 2007 | 17526767 |
| lignan-rich sesame seed negates the tumor-inhibitory effect of tamoxifen but maintains bone health in a postmenopausal athymic mouse model with estrogen-responsive breast tumors. | flaxseed, the richest source of mammalian lignan precursors, enhances the tumor growth-inhibitory effect of tamoxifen while exerting no adverse effects on other estrogen-responsive tissues such as bone. ingestion of sesame seed produces mammalian lignans comparable with flaxseed, but its anticancer potential is unknown. this study determined the interactive effects of sesame seed and tamoxifen on established mcf-7 tumor growth and bone health in ovariectomized athymic mice simulating a postmenop ... | 2008 | 17545920 |
| minimizing the central hydrophobic domain in oleosin for the constitution of artificial oil bodies. | oleosin, a unique structural protein anchoring onto the surface of seed oil bodies by its central hydrophobic domain, stabilizes these lipid-storage organelles as discrete entities. stable artificial oil bodies have been successfully constituted with native or recombinant oleosins. in this study, recombinant sesame oleosin with 12 residues stepwise truncated from its central hydrophobic domain of 72 residues was overexpressed in escherichia coli, was purified to homogeneity, and was used for the ... | 2007 | 17567149 |
| susceptibility of human pathogenic bacteria to antimicrobial peptides from sesame kernels. | hospital infection caused by gram-negative bacteria is a serious and common problem, especially in developing countries. aiming to reduce these infections, this report focuses on the identification and characterization of novel antimicrobial peptides from sesame (sesamum indicum) kernel meals. thus, sesame flour was extracted and precipitated with ammonium sulfate (100%). after dialysis, a rich fraction was applied to affinity red-sepharose cl-6b chromatography, followed by reversed-phase high-p ... | 2007 | 17570014 |
| ameliorative influence of sesame lignans on lipid profile and lipid peroxidation in induced diabetic rats. | sesame lignans are working as antioxidants in various physiological functions. in the present study, the antioxidative effect of sesame lignans is examined in chemically induced diabetes mellitus (dm) in rats against lipid profile and lipid peroxidations. dm was induced in four groups of rats by injection of alloxan. the control groups (non-diabetic and diabetic) received a diet containing sunflower oil while the rest of the three experimental diabetic groups received a diet containing 0.25% alp ... | 2007 | 17571897 |
| molecular and biochemical characterizations of dehydroascorbate reductase from sesame (sesamum indicum l.) hairy root cultures. | dehydroascorbate reductase (dhar) is a biotechnologically or physiologically important reducing enzyme in the ascorbate-glutathione recycling reaction for most higher plants. a dhar cdna was isolated from sesame (sesamum indicum l.) hairy roots, and its structure and biochemical properties were characterized to provide some information about its expressional and biochemical profiles in the hairy root cultures. the cdna contained a catalytic motif cxxs, which may be indicative of a thiol-dependen ... | 2007 | 17602657 |
| effect of progesterone on recovery from nerve injury during leg lengthening in rats. | we investigated the effect of progesterone on the nerve during lengthening of the limb in rats. the sciatic nerves of rats were elongated by leg lengthening for ten days at 3 mm per day. on alternate days between the day after the operation and nerve dissection, the progesterone-treated group received subcutaneous injections of 1 mg progesterone in sesame oil and the control group received oil only. on the fifth, tenth and 17th day, the sciatic nerves were excised at the midpoint of the femur an ... | 2007 | 17613514 |
| androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance. | although androgen secretion is reduced with aging, and may underlie decrements in cognitive and affective performance, the effects and mechanisms of androgens to mediate these behaviors are not well understood. testosterone (t), the primary male androgen, is aromatized to estrogen (e(2)), and reduced to dihydrotestosterone (dht), which is converted to 5alpha-androstane, 3alpha, 17beta-diol (3alpha-diol). to ascertain whether actions of the neuroactive metabolite of t, 3alpha-diol, mediates cogni ... | 2008 | 17625503 |
| [rhizobium/legume symbiose: a new sesame]. | 2007 | 17631847 | |
| sesamin, a lignan of sesame, down-regulates cyclin d1 protein expression in human tumor cells. | sesamin is a major lignan constituent of sesame and possesses multiple functions such as antihypertensive, cholesterol-lowering, lipid-lowering and anticancer activities. several groups have previously reported that sesamin induces growth inhibition in human cancer cells. however, the nature of this growth inhibitory mechanism remains unknown. the authors here report that sesamin induces growth arrest at the g1 phase in cell cycle progression in the human breast cancer cell line mcf-7. furthermo ... | 2007 | 17640297 |
| characterization of buckwheat 19-kd allergen and its application for diagnosing clinical reactivity. | the 19-kd protein of buckwheat (bw) has been suggested to be a major allergen, but its characteristics and clinical significance are poorly defined. | 2007 | 17641547 |
| the effects of estrogen and testosterone on gene expression in the rat mesenteric arteries. | a dramatic difference exists in the timing of development of cardiovascular disease in men vs. women. the primary candidates underlying the cause of this gender difference are the sex steroids, estrogen and testosterone. the vasculature is considered to be a site of action of these steroids. in spite of these concepts there is little data on the direct effects of estrogen and testosterone on gene expression in the vasculature. in this study, ovariectomized sprague dawley rats were treated for 4 ... | 2007 | 17652031 |
| dietary exposure estimation of benzo[a]pyrene and cancer risk assessment. | dietary benzo[a]pyrene (bap) levels were analyzed by high-performance liquid chromatography with fluorescence detection (hplc-fld) in various foods (e.g., snack, potato chip, bread, vegetable oil, meat, cereal, etc.) to estimate dietary intake levels of bap for the assessment of bap related-cancer risk in koreans. higher levels of bap were detected in fried chicken (5.25-5.55 bap microg/kg) and smoked dried beef (5.47 microg/kg) compared to relatively lower levels measured in sesame oil (0.36 mi ... | 2007 | 17654259 |
| phytase production by a thermophilic mould sporotrichum thermophile in solid state fermentation and its potential applications. | phytase production by a thermophilic mould sporotrichum thermophile apinis was investigated in solid state fermentation (ssf) using sesame oil cake as the substrate. scanning electron microscopy of the fermented sesame oil cake revealed a dense growth of the mould with abundant conidia. glucose, ammonium sulphate and incubation period were identified as the most significant factors by plackett-burman design. the optimum values of the critical components determined by central composite design of ... | 2008 | 17681787 |
| estrogen abolishes latent inhibition in ovariectomized female rats. | estrogen is frequently prescribed as a method of birth control and as hormone replacement therapy for post-menopausal women with varied effects on cognition. here the effects of estrogen on attention were examined using the latent inhibition (li) behavioral paradigm. ovariectomized (ovx) female rats were given either estrogen benzoate (eb, 10 or 100 microg/ml/kg; sc) or sesame oil vehicle. males and ovx females receiving vehicle displayed normal li. in contrast, li was abolished in ovx females r ... | 2008 | 17693005 |
| pyrogen testing of lipidic parenterals with a novel in vitro test--application of the ipt based on cryopreserved human whole blood. | the european pharmacopoeia has made the testing of small volume parenterals (< 15) obligatory since 2004. this concerns many formulations, e.g. vitamins, steroids and hormones, many of which are applied intramuscularly using a lipidic carrier. lipopolysaccharides, the best established endotoxins from gram-negative bacteria, bind strongly to lipophilic substances, which mask them in limulus amebocyte lysate assays. end-product testing, therefore, can only be carried out in rabbit pyrogen tests. t ... | 2006 | 17694639 |
| dietary effects of structured lipids and phytosteryl esters on cardiovascular function in spontaneously hypertensive rats. | this study examined the dietary effects of sesame oil (so)-based structured lipids (sl) and phytosteryl esters (pe) on cardiovascular function in conscious spontaneously hypertensive rats (shr) fed high-fat (hf) diets (20% w/w fat). the dietary groups were as follows: normal diet (4.5% w/w fat), so, so fortified with pe (sop), sl, and sl fortified with pe (slp). mean arterial blood pressures were similar in all groups, whereas resting heart rates (hr) were higher in all hf-fed groups. the presso ... | 2007 | 17703134 |
| the role of nitric oxide in the effects of ovarian steroids on spontaneous myometrial contractility in rats. | forty ovariectomized rats were apportioned into one control and three experimental groups (n=10 each) to evaluate the role of nitric oxide in the effects of ovarian steroids on spontaneous myometrial contractility in rats. the control group (group ov) received sesame oil once daily for 10 days, whereas rats in the experimental groups were treated with progesterone (2 mg/(rat day); group p), 17beta-estradiol (10 microg/(rat day); group e2), or progesterone and 17beta-estradiol together (group e2+ ... | 2007 | 17869333 |
| antimutagenic properties of a polyphenol-enriched extract derived from sesame-seed perisperm. | a polyphenolic mixture derived from sesame-seed perisperm (ssp) strongly reduced the mutagenicity of hydrogen peroxide (h(2)o(2)), sodium azide (nan(3)), and benzo[a]pyrene (bap) in strains ta100 and/or ta98 of salmonella typhimurium. it exhibited desmutagenic activity against h(2)o(2), bap in ta98 and/or ta100 and biomutagenic activity (apparently by affecting the dna-repair system) against nan(3) in strain ta100. according to in vitro experiments the polyphenolic mixture inhibited the activity ... | 2007 | 17870654 |