Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| ingol and ingenol diterpenes from the aerial parts of euphorbia royleana and their antiangiogenic activities. | ten new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of euphorbia royleana. the structures of 1-10 were elucidated on the basis of spectroscopic methods including 2d nmr analysis, and the structure of compound 1 was confirmed by single-crystal x-ray crystallography. antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay. | 2009 | 19438253 |
| supinaionosides a and b: megastigmane glucosides and supinanitrilosides a-f: hydroxynitrile glucosides from the whole plants of euphorbia supina rafinesque. | from whole plants of euphorbia supina, two new megastigmane glucosides, named supinaionosides a and b (1, 2), six new hydroxynitrile glucosides, named supinanitrilosides a-f (3-8), and six known compounds were isolated. the structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidence. | 2009 | 19652410 |
| total synthesis of jatrophane diterpenes from euphorbia characias. | the enantioselective total synthesis of the jatrophane diterpene (-)-15-o-acetyl-3-o-propionylcharaciol is described. starting from an advanced cyclopentane building block, a b-alkyl suzuki-miyaura cross-coupling and carbonyl addition were utilized to assemble a fully functionalized triene, and a ring-closing metathesis was then employed to construct the rigid 12-membered ring. twenty-five years after the original report on the isolation of the natural product, our total synthesis unambiguously ... | 2009 | 19453178 |
| lathyrane diterpenes from euphorbia lathyris as modulators of multidrug resistance and their crystal structures. | two lathyrane diterpenes (1-2) together with previous ones (3-6) were isolated from euphorbia lathyris. the structures of 1 and 2 were established on the basis of extensive spectroscopic methods, including two-dimensional nmr techniques. stereo configuration and conformation of 1 and 2 were analyzed by x-ray diffraction for the first time. the configuration of the unique isolathyrol diterpene 2 from the seeds of e. lathyris, was rectified from s * to r * at c-5. all compounds were examined as mo ... | 2009 | 19443229 |
| inhibitory effects of solidago chilensis meyen hydroalcoholic extract on acute inflammation. | alcoholic or hydroalcoholic preparations of the plant solidago chilensis meyen (asteraceae) are employed in popular medicines to treat inflammation. the anti-inflammatory effects of the hydroalcoholic extract of aerial parts of the plant (93% ethanol) were investigated and the main components of the extract were identified. | 2009 | 19429316 |
| evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some yemeni plants used in folk medicine. | the present research study deals with the evaluation of sixty four methanolic and aqueous extracts of thirty yemeni plants used in traditional medicine for their in vitro antiproliferative activity against three human cancer cell lines in a microtiter plate assay based on cellular staining with crystal violet, for their antimicrobial activity against antibiotic susceptible three gram-positive, three gram-negative bacterial and one fungal stains and three multiresistant staphylococcus strains by ... | 2009 | 19435146 |
| not just vicariance: phylogeography of a sonoran desert euphorb indicates a major role of range expansion along the baja peninsula. | to examine the generality of population-level impacts of ancient vicariance identified for numerous arid-adapted animal taxa along the baja peninsula, we tested phylogeographical hypotheses in a similarly distributed desert plant, euphorbia lomelii (euphorbiaceae). in light of fossil data indicating marked changes in the distributions of baja floristic assemblages throughout the holocene and earlier, we also examined evidence for range expansion over more recent temporal scales. two classes of c ... | 2009 | 19302467 |
| vanilloid-mediated apoptosis in prostate cancer cells through a trpv-1 dependent and a trpv-1-independent mechanism. | vanilloids are natural molecules identified in a plethora of foods normally ingested through the diet. they mediate apoptosis through a direct pathway (independent of trpv-1, the receptor for vanilloids) and through an indirect pathway, i.e., thanks to the interaction with trpv-1 and the successive intracellular calcium growth [ca2+]i. some vanilloids, such as capsaicin, dihydrocapsaicin and resiniferatoxin (the ultrapotent analogue of capsaicin, extractable from euphorbia resinifera), may be co ... | 2009 | 19705615 |
| a case of acute keratoconjunctivitis from exposure to latex of euphorbia tirucalli (pencil cactus). | we present a case of a 40-year-old man who suffered chemical eye injury from the latex of euphorbia tirucalli (pencil cactus), resulting in acute keratoconjunctivitis. the euphorbia genus of plants contains numerous species widely distributed throughout all major continents, and therefore this may be a more common emergency department occurrence than previously thought. | 2009 | 17976795 |
| biological screening of euphorbia helioscopia l. | the present research is preliminary biological screening of euphorbia helioscopia l. (euphorbiaceae). dichloromethane and methanol extracts of the aerial parts of the plant were investigated for their antioxidant, antifungal, antibacterial and phytotoxic activities. dichloromethane extract exhibited significant activity against fusarium solani with 90% inhibition, where as the same extract also showed non-significant activity against salmonella typhi and bacillus subtilis. methanolic extract has ... | 2009 | 19339230 |
| ethnopharmacological survey of wild medicinal plants in showbak, jordan. | two main research questions are framing this investigation: (1) the main taxa of the medicinal importance value altered the showbak forest stand and species composition? (2) the most safe species and what are the toxic ones (unsafe). these two research questions are the vital ones to draw a clear image about the wild medicinal plants of this investigated area of showbak region in jordan. 79 wild medicinal plant species were investigated in this study which are used in traditional medication for ... | 2009 | 19429338 |
| [terpenoids from euphorbia antiquorum l.]. | to study the chemical constituents of euphorbia antiquorum l., the constituents were isolated with normal-phase and reverse-phase silica gel column chromatography and their structures were elucidated on the basis of spectroscopic data. seven terpenoids were obtained from etoac extract of e. antiquoru l. they were identified as antiquorine a (1), antiquorine b (2), ent-13s-hydroxy-16-atisene-3,14-dione (3), taraxerol (4), 3beta-hydroxy-25,26,27-trisnorcycloart-24-oic acid (5), 9beta,19-cyclolanos ... | 2009 | 20055134 |
| multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from euphorbia species. | one of the most promising strategies to overcome multidrug resistance (mdr) is to use compounds that can modulate p-glycoprotein and restore the cytotoxicity of anticancer drugs. furthermore, the search for compounds that regulate and overcome apoptosis deficiency of cancer cells is also of great therapeutic importance. | 2009 | 20032393 |
| [studies on the chemical constituents from euphorbia chrysocoma]. | to study the chemical constituents from the aerial part of euphorbia chrysocoma. | 2009 | 20034213 |
| exposure to euphorbia lathyris latex resulting in alkaline chemical injury: a case report. | we report the case of a patient with extreme pain following accidental exposure to the latex of euphorbia lathyris. | 2009 | 19946593 |
| isolation and characterization of microsatellite loci for euphorbia palustris (euphorbiaceae). | swamp spurge (euphorbia palustris, euphorbiaceae) is a large perennial species of wet grassland and swamps. its natural habitats are fragmented and isolated both naturally and owing to habitat destruction by human activity. thus the species is endangered and legally protected in germany. this report describes seven novel polymorphic microsatellite loci that will be helpful to characterize genetic variation and to analyze the population genetic structure and levels of gene flow within and among p ... | 2009 | 19953131 |
| 13c-nmr data of three important diterpenes isolated from euphorbia species. | euphorbia species are widely distributed plants, many of which are used in folk medicine. over the past twenty years, they have received considerable phytochemical and biological attention. their diterpenoid constituents, especially those with abietane, tigliane, ingenane skeletons, are thought to be the main toxicant and bioactive factors. in this work, the utility of (13)c-nmr spectroscopy for the structural elucidation of these compounds is briefly discussed. | 2009 | 19924079 |
| the grape component piceatannol induces apoptosis in du145 human prostate cancer cells via the activation of extrinsic and intrinsic pathways. | piceatannol (trans-3,4,3',5'-tetrahydroxystilbene) is a polyphenol that is found in grapes, red wine, rheum undulatum, and the seeds of euphorbia lagascae. it has been previously reported that piceatannol inhibits the proliferation of a variety of cancer cell types. in the present study, we assessed the effects of piceatannol on the growth of androgen-insensitive du145 prostate cancer cells at concentrations of 1-10 micromol/l. piceatannol reduced the viable numbers and increased the numbers of ... | 2009 | 19857055 |
| amaranthus oleracea and euphorbia hirta: natural potential larvicidal agents against the urban indian malaria vector, anopheles stephensi liston (diptera: culicidae). | malaria control in developing countries is based largely on vector eradication by the use of mosquito larvicides which is an ideal method for controlling mosquito and the related epidemics. on account of ecohazardous nature, nontarget specificity of chemical insecticides and evidences of developing resistance against them in the exposed species, currently, importance of secondary plant metabolites has been acknowledged. insecticides of plant origin are environmentally safe, degradable, and targe ... | 2009 | 19838734 |
| müllerian mimicry in aposematic spiny plants. | müllerian mimicry is common in aposematic animals but till recently, like other aspects of plant aposematism was almost unknown. many thorny, spiny and prickly plants are considered aposematic because their sharp defensive structures are colorful and conspicuous. many of these spiny plant species (e.g., cacti and agave in north american deserts; aloe, euphorbia and acacias with white thorns in africa; spiny plants in ohio; and spiny members of the asteraceae in the mediterranean basin) have over ... | 2009 | 19816137 |
| potential plant poisonings in dogs and cats in southern africa. | plant poisoning occurs less commonly in dogs and cats than in herbivorous livestock, but numerous cases have been documented worldwide, most of them caused by common and internationally widely cultivated ornamental garden and house plants. few cases of poisoning of cats and dogs have been reported in southern africa, but many of the plants that have caused poisoning in these species elsewhere are widely available in the subregion and are briefly reviewed in terms of toxic principles, toxicity, s ... | 2009 | 19831265 |
| the phytotoxic effect of exogenous ethanol on euphorbia heterophylla l. | this study investigated the effects of exogenously applied ethanol on euphorbia heterophylla l., a troublesome weed in field and plantation crops. ethanol at concentrations ranging from 0.25 to 1.5% caused a dose-dependent inhibition of germination and growth of e. heterophylla. measurements of respiratory activity and alcohol dehydrogenase (e.c. 1.1.1.1) activity during seed imbibition and initial seedling growth revealed that ethanol induces a prolongation of hypoxic conditions in the growing ... | 2009 | 19640725 |
| mutagenic and antimutagenic activities of aqueous and methanol extracts of euphorbia hirta. | euphorbia hirta (e. hirta) is a weed commonly found in tropical countries and has been used traditionally for asthma, bronchitis and conjunctivitis. however, one of the constituents in this plant, quercetin, was previously reported to be mutagenic. this work aimed to determine the level of quercetin in the aqueous and methanol plant extracts and to investigate the mutagenic effects of quercetin and the extracts in the ames test utilising the mutant salmonella typhimurium ta98 and ta100 strains. ... | 2009 | 19778596 |
| kiom-79, an inhibitor of ages-protein cross-linking, prevents progression of nephropathy in zucker diabetic fatty rats. | advanced glycation end products (ages) have been implicated in the development of diabetic complications, including diabetic nephropathy. kiom-79, an 80% ethanolic extract obtained from parched puerariae radix, gingered magnolia cortex, glycyrrhiza radix and euphorbia radix, was investigated for its effects on the development of renal disease in zucker diabetic fatty rats, an animal model of type 2 diabetes. in vitro inhibitory effect of kiom-79 on ages cross-linking was examined by enzyme-linke ... | 2009 | 19605553 |
| effect of commercially available plant-derived essential oil products on arthropod pests. | plant-derived essential oil products, in general, are considered minimum-risk pesticides and are exempt from environmental protection agency registration under section 25(b) of the federal insecticide fungicide and rodenticide act. however, many of the plant-derived essential products available to consumers (homeowners) have not been judiciously evaluated for both efficacy and plant safety. in fact, numerous plant-derived essential oil products labeled for control of arthropod pests have not bee ... | 2009 | 19736770 |
| [apigenin glycosides from euphorbia humifusa wild]. | the investigation on the herbal of euphorbia humifusa wild. was carried out in order to find its anti-hbv constituents. the isolation and purification were performed by chromatography such as sephadex lh-20, mci gel chp 20p, etc. based on the spectral analysis, five apigenin glycosides were identified as apigenin-7-o-(6"-o-galloyl)-beta-d-glucopyranoside (1), apigenin-7-o-beta-d-apiofuranosyl (1-->2)-beta-d-glucopyranoside (2), apigenin-7-o-beta-d-lutinoside (3), apigenin-7-o-beta-d-glucopyransi ... | 2009 | 19618725 |
| diterpenoids and triterpenoids from euphorbia retusa. | six new ent-abietane lactones (1-6), three new esterified tetracyclic triterpenes (7-9), and seven known diterpenoids and triterpenoids were isolated from the roots of euphorbia retusa. their structures were elucidated by means of spectroscopic studies including 1d and 2d nmr, mass spectrometry, chemical transformation, and comparison with literature data. | 2009 | 19518124 |
| a new cytotoxic casbane diterpene from euphorbia pekinensis. | a new cytotoxic casbane diterpene, named pekinenal, was isolated from the roots of euphorbia pekinensis. its structure was elucidated as 5alpha-hydroxy-1betah,2alphah-casba-3z,7e,11e-triene-18-al by a combination of 1d- and 2d-nmr techniques and confirmed by x-ray crystallography. pekinenal showed cytotoxic activity against all four human cancer cell lines tested. | 2009 | 19560525 |
| a kinetically stable plant subtilase with unique peptide mass fingerprints and dimerization properties. | milin, a potent molluscicide from the latex of euphorbia milii, holds promise in medicinal biochemistry. electrophoresis, size exclusion chromatography, mass spectrometry and other biochemical characteristics identify milin as a homodimeric, plant subtilisin-like serine protease, the first of its kind. the subunits of milin are differentially glycosylated affecting dimer association, solubility and proteolytic activity. the dimeric dissociation is sds-insensitive and strongly temperature depende ... | 2009 | 18951690 |
| keratouveitis caused by euphorbia plant sap. | the milky sap or latex of euphorbia plant is highly toxic and an irritant to the skin and eye. this report illustrates the spectrum of ocular inflammation caused by accidental inoculation of latex of euphorbia plant. three patients presented with accidental ocular exposure to the milky sap of euphorbia species of recent onset. the initial symptoms in all cases were severe burning sensation with blurring of vision. visual acuity reduced from 20/60 to counting fingers. clinical findings varied fro ... | 2009 | 19574703 |
| 17-hydroxy-jolkinolide b inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking janus kinases and induces apoptosis of human cancer cells. | constitutive activation of the janus kinase (jak)/signal transducer and activator of transcription (stat) pathway occurs frequently in cancer cells and contributes to oncogenesis. among the members of stat family, stat3 plays a pivotal role in the development and progression of human tumors. the stat3-mediated signaling pathway has been recognized as a promising anticancer target. here, we show that 17-hydroxy-jolkinolide b (hjb), a diterpenoid from the chinese medicinal herb euphorbia fischeria ... | 2009 | 19706767 |
| the inhibitory effect of phytoclear-el1 on melanogenesis. | phytoclear-el1, an extract from euphorbia lathyris seeds, has a whitening effect due to inhibition of tyrosinase activity. | 2009 | 20523826 |
| 3α-hydr-oxy-ent-atis-16-en-14-one. | the title compound, c(20)h(30)o(2), is an ent-atisane diterpenoid which was isolated from the roots of euphorbia kansuensis. the mol-ecule contains five six-membered rings, among which three six-membered rings of the bicyclo-[2.2.2]octane unit adopt boat conformations and two cyclo-hexane rings adopt chair conformations. in the crystal structure, mol-ecules are connected by inter-molecular o-h⋯o hydrogen bonds, forming zigzag chains propagating parallel to [001]. | 2009 | 21583534 |
| scaling relations for a functionally two-dimensional plant: chamaesyce setiloba (euphorbiaceae). | many characteristics of plants and animals scale with body size as described by allometric equations of the form y = βm(α), where y is an attribute of the organism, β is a coefficient that varies with attribute, m is a measure of organism size, and α is another constant, the scaling exponent. in current models, the frequently observed quarter-power scaling exponents are hypothesized to be due to fractal-like structures. however, not all plants or animals conform to the assumptions of these model ... | 2009 | 21628240 |
| identification of begomoviruses infecting crops and weeds in belize. | plants including pepper, red kidney bean, squash, string bean and tomato, as well as weeds with viral symptoms were collected from five districts in belize over a three year period with the aim of determining the diversity of the begomoviruses present. sixty five percent of the samples screened via dna hybridization produced signals indicative of begomovirus infection. subsequent pcr amplifications and nucleotide sequence analyses revealed the presence of four begomoviruses in belize. pepper gol ... | 2008 | 20596296 |
| effect of cycloart-24-en-3beta-ol from euphorbia royleana latex on neuroenzyme ache and oxidative metabolism of freshwater fish, channa punctatus. | cycloart-24-en-3beta-ol isolated from euphorbia royleana latex possesses potent piscicidal activity against freshwater predatory fish channa punctatus. their short as well as long-term exposure causes significant (p<0.05) time and dose-dependent reversible alteration in the oxidative metabolism of the fish channa punctatus cycloart-24-en-3beta-ol also shifts fish respiratory pathway, inhibits energy production and ache activity reversibly may be advantageous for their use as environmentally safe ... | 2008 | 20161954 |
| purification, biochemical and functional characterization of miliin, a new thiol-dependent serine protease isolated from the latex of euphorbia milii. | miliin, a new thiol-dependent serine protease purified from the latex of euphorbia milii possesses a molecular weight of 79 kda, an isoelectric point of 4.3 and is optimally active at 60 degrees c in the ph range of and 7.5-11.0. activity tests indicate that milliin is a thiol-dependent serine protease. | 2008 | 18782069 |
| synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells. | the macrocyclic lathyrane diterpene latilagascene b, previously isolated from euphorbia lagascae, was acylated to afford three new diterpene esters, latilagascenes g (1), h (2), and i (3), whose structures were assigned by spectroscopic methods. these acyl derivatives, and the macrocyclic diterpenes of the jatrophane-type, tuckeyanols a (4) and b (5), and euphotuckeyanol (6), isolated from euphorbia tuckeyana, were tested for p-gp modulating properties on human mdr1 gene-transfected and parental ... | 2008 | 18824363 |
| new alpha-pyrrolidinonoids and glycosides from euphorbia humifusa. | a phytochemical investigation on the constituents from euphorbia humifusa willd. has resulted in the isolation of three new alpha-pyrrolidinonoidal compounds, 5beta-methoxy-4beta-hydroxy-3-methylene-alpha-pyrrolidinone (1), 5beta-methoxy-4alpha-hydroxy-3-methylene-alpha-pyrrolidinone (2), and 5beta-butoxy-4alpha-hydroxy-3-methylene-alpha-pyrrolidinone (3), and three new glycosides including an indole glycoside, 3-(2-hydroxyethyl)-5-(1-o-beta-glucopyranosyloxy)-indole (4), an ionone glycoside, 3- ... | 2008 | 18470805 |
| heavy metal accumulation in medicinal plants collected from environmentally different sites. | to estimate the heavy metal content in soil and selected medicinal plants procured from environmentally different sites of the same city. | 2008 | 18837296 |
| phenotypical differences among b. cinerea isolates from ornamental plants. | b. cinerea is a common pathogenic fungus which causes botrytis blight (grey mould) in most ornamental plants. it may be responsible for serious preharvest diseases and postharvest losses in fruits, vegetables and flowers. in this work, several b. cinerea isolates from ornamental plants (chamelaucium uncinatum, pelargonium x hortorum, euphorbia pulcherrima, lantana camara, lonicera japonica, hydrangea macrophylla, and cyclamen persicum) affected by botrytis blight in the south of spain were studi ... | 2008 | 19226749 |
| [studies on macrocyclic jatrophane diterpenes of euphorbia kansui]. | to study macrocyclic jatrophane diterpenes of euphorbia kansui. | 2008 | 19007010 |
| keratouveitis caused by sap of euphorbia myrsinites plant. | euphorbia plants grow in many gardens. their milky latex is, however, a strong irritant which may induce various ocular lesions from keratoconjunctivitis to severe uveitis. | 2008 | 18454396 |
| chemical and pharmacological research of the plants in genus euphorbia. | 2008 | 18817355 | |
| antisickling activity of anthocyanins from bombax pentadrum, ficus capensis and ziziphus mucronata: photodegradation effect. | a survey was conducted in lubumbashi city (democratic republic of congo) in order to: (a) identify medicinal plants used by traditional healers in the management of sickle cell anaemia, (b) verify their antisickling activity in vitro, (c) determine the most active plants, and (d) verify if anthocyanins are responsible of the bioactivity and study their photodegradation effect. | 2008 | 18930798 |
| induction of heme oxygenase-1 by plant extract kiom-79 via akt pathway and nf-e2 related factor 2 in pancreatic beta-cells. | the objective of the present study was to determine the mechanism by which kiom-79 induced heme oxygenase-1 (ho-1) in rat pancreatic beta-cells (rinm5f). a mixture of plant extracts (kiom-79) was obtained from magnolia officinalis, pueraria lobata, glycyrrhiza uralensis, and euphorbia pekinensis. ho-1, an antioxidant phase 2 enzyme, was previously reported to possess cytoprotective properties in pancreatic beta-cells. kiom-79 induced heme oxygenase-1 (ho-1) expression at the mrna and protein lev ... | 2008 | 18704831 |
| termiticidal activity of diterpenes from the roots of euphorbia kansui. | five ingenane compounds, 1-5, kansuinins a and b, isolated from euphorbia kansui, and their derivatives 7 and 9 were tested for termiticidal activity against the japanese termite, reticulitermes speratus. at 72 hours after treatment, the ingenane compounds 1 to 5 caused 100% mortality in r. speratus at 50, 25 and 12.5 microg/disk, respectively, except for compound 1, which gave a mortality rate of (93.06 +/- 5.56)% at 12.5 microg/disk. at 36, 48 and 60 hours after treatment, compounds 1 to 5 sho ... | 2008 | 18386488 |
| antinematodal activities of ingenane diterpenes from euphorbia kansui and their derivatives against the pine wood nematode (bursaphelenchus xylophilus). | under the bioassay-guided method, two diterpenes, 3-o-(2",3"-dimethylbutanoyl)-13-o-dodecanoylingenol (1) and 3-o-(2",3"-dimethylbutanoyl)-13-o-decanoylingenol (2) isolated from euphorbia kansui, showed a pronounced antinematodal activity against the nematode bursaphelenchus xylophilus at the same minimum effective dose (med) of 5 microg per cotton ball and still displayed antinematodal activity at a dose of 2.5 microg per cotton ball. compounds 3-6 were obtained, and the structure of the new co ... | 2008 | 18386489 |
| euphorbia hirta reverses chronic stress-induced anxiety and mediates its action through the gaba(a) receptor benzodiazepine receptor-cl(-) channel complex. | chronic stress is known to result in impairment of learning and memory and precipitate several affective disorders including depression and anxiety. drugs of natural origin are known to possess several effects on the central nervous system and are emerging as promising alternative therapies. in this context, the hydroalcoholic extract of euphorbia hirta (eh) was evaluated for anxiolytic property in chronically stressed rats subjected to elevated plus maze (epm) and open field test (oft). eh trea ... | 2008 | 18087670 |
| [mites (acari) from rubber trees (hevea brasiliensis muell. arg., euphorbiaceae) and spontaneous euphorbiaceous in rubber trees cultivation]. | quarterly samples were done in 2001 on three rubber tree plantation in the northwest of the state of são paulo. three rubber trees of each locality were sampled. between the rows of rubber tree four species of spontaneous euphorbiaceous were collected: chamaesyce hirta, c. hyssopifolia, euphorbia heterophylla and phyllanthus tenellus. a total of 8.954 mites of 38 species, belonging to 31 genera of 11 families were collected. tydeidae and phytoseiidae had the highest diversity of species, 9 and 7 ... | 2008 | 18813750 |
| in vitro anti-influenza screening of several euphorbiaceae species: structure of a bioactive cyanoglucoside from codiaeum variegatum. | a bio-guided screening against influenza a virus (fluav) was carried out with seven euphorbiaceae species. the results showed that chromatographic fractions from phyllantus niruri, euphorbia pulcherrima and codiaeum variegatum had relevant anti-fluav activity, although only chromatographical subfractions from c. variegatum kept the activity. from this plant, the active compound against fluav was isolated. its structure was assigned as 2-(3,4,5)-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxyme ... | 2008 | 18851862 |
| 17-acetoxyjolkinolide b irreversibly inhibits ikappab kinase and induces apoptosis of tumor cells. | nuclear factor-kappab (nf-kappab) is critically important for tumor cell survival, growth, angiogenesis, and metastasis. one of the key events in the nf-kappab signaling is the activation of inhibitor of nf-kappab kinase (ikk) in response to stimuli of various cytokines. we have identified 17-acetoxyjolkinolide b (17-ajb) from a traditional chinese medicinal herb euphorbia fischeriana steud as a novel small-molecule inhibitor of ikk. 17-ajb effectively inhibited tumor necrosis factor-alpha-induc ... | 2008 | 18566223 |
| bioactive triterpene derivatives from latex of two euphorbia species. | we have investigated the antifeedant and toxic effects of 23 semisynthetic terpenoid derivatives obtained through chemical modifications of the major components of euphorbia resinifera (alpha-euphol and alpha-euphorbol) and e. officinarum (obtusifoliol and 31-norlanostenol) latex on several insect species (spodoptera littoralis, myzus persicae and rhopalosiphum padi), their selective cytotoxicity on insect sf9 and mammalian cho cells and their phytotoxic effects on lactuca sativa. the conversion ... | 2008 | 18304594 |
| alternative and complementary antileishmanial treatments: assessment of the antileishmanial activity of 27 lebanese plants, including 11 endemic species. | aqueous, methanolic, and dichloromethane extracts from 27 lebanese plants were investigated for their in vitro immunomodulatory and antileishmanial activities as compared to their toxicity against human cells. extracts from yellow chamomile (anthemis tinctoria), white larkspur (consolida rigida), syrian broom (cytisus syriacus), coast spurge (euphorbia paralias), shield fibigia (fibigia clypeata), auchers golden-drop (onosma aucheriana), shell-flower sage (salvia multicaulis), snowy woundwort (s ... | 2008 | 18315506 |
| two new diterpenes from euphorbia kansuensis. | two new lathyrane diterpenes, 3beta,5alpha-dihydroxy-15beta-cinnamoyloxy-14-oxolathyra-6z,12e -diene (1) and 3beta,5alpha,20-trihydroxy-15beta-cinnamoyloxy-14-oxolathyra-6z,12e-diene (2), were isolated from the roots of euphorbia kansuensis. their structures were determined by spectroscopic methods. | 2008 | 18372116 |
| evolved glyphosate-resistant weeds around the world: lessons to be learnt. | glyphosate is the world's most important herbicide, with many uses that deliver effective and sustained control of a wide spectrum of unwanted (weedy) plant species. until recently there were relatively few reports of weedy plant species evolving resistance to glyphosate. since 1996, the advent and subsequent high adoption of transgenic glyphosate-resistant crops in the americas has meant unprecedented and often exclusive use of glyphosate for weed control over very large areas. consequently, in ... | 2008 | 18273881 |
| removal of disperse dye from aqueous solution by novel adsorbent prepared from biomass plant material. | the adsorption of disperse orange 25 (3-[n-ethyl-4-(4-nitrophenylazo) phenylamino] propionitrile) onto activated carbon was investigated in a batch system with respect to contact time, carbon dosage, ph and temperature from aqueous solutions. the langmuir, freundlich and dubinin-radushkevich (d-r) adsorption models were applied to describe the equilibrium isotherms and the isotherm constants were also determined. the langmuir isotherm model agrees with the experimental data well. maximum adsorpt ... | 2008 | 18448248 |
| agrobacterium tumefaciens-mediated transformation of poinsettia, euphorbia pulcherrima, with virus-derived hairpin rna constructs confers resistance to poinsettia mosaic virus. | agrobacterium-mediated transformation for poinsettia (euphorbia pulcherrima willd. ex klotzsch) is reported here for the first time. internode stem explants of poinsettia cv. millenium were transformed by agrobacterium tumefaciens, strain lba 4404, harbouring virus-derived hairpin (hp) rna gene constructs to induce rna silencing-mediated resistance to poinsettia mosaic virus (pnmv). prior to transformation, an efficient somatic embryogenesis system was developed for poinsettia cv. millenium in w ... | 2008 | 18327592 |
| chromosome number and cytogenetics of euphorbia heterophylla l. | euphorbia heterophylla l. (euphorbiaceae) is a herbaceous species of great economic importance due to its invasive potential and consequent damage to agriculture and pasture land. for the first time, we provide information on its chromosome number, morphology, and behavior of mitotic chromosomes. seeds were germinated and submitted to four treatments to obtain metaphases: 0.5% colchicine for 2 to 5 h, at ambient temperature; 0.5% colchicine for 16 to 24 h; 0.0029 m 8-hydroxyquinoline (8-hq) for ... | 2008 | 18393225 |
| effects of protein kinase c modulation by pep005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. | pep005 (ingenol-3-angelate) is a novel anticancer agent extracted from euphorbia peplus that was previously shown to modulate protein kinase c (pkc), resulting in antiproliferative and proapoptotic effects in several human cancer cell lines. in colo205 colon cancer cells, exposure to pep005 induced a time- and concentration-dependent decrease of cells in s phase of cell cycle and apoptosis. in colo205 cells exposed to pep005, a variety of signaling pathways were activated as shown by increased p ... | 2008 | 18413805 |
| tyramine oxidation by copper/tpq amine oxidase and peroxidase from euphorbia characias latex. | tyramine, an important plant intermediate, was found to be a substrate for two proteins, a copper amine oxidase and a peroxidase from euphorbia characias latex. the oxidation of tyramine took place by two different mechanisms: oxidative deamination to p-hydroxyphenylacetaldehyde by the amine oxidase and formation of di-tyramine by the peroxidase. the di-tyramine was further oxidized at the two amino groups by the amino oxidase, whereas p-hydroxyphenylacetaldehyde was transformed to di-p-hydroxyp ... | 2008 | 18423366 |
| discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific p-glycoprotein modulators. | a new series of diterpenes, the jatrophanes euphoscopin m (1), euphoscopin n (2) and euphornin l (3), and the lathyrane euphohelioscopin c (7) were isolated from plants of euphorbia helioscopia l., together with four other known analogues, euphoscopin c (4), euphornin (5), epieuphoscopin b (6) and euphohelioscopin a (8). the new compound stereostructures were elucidated by nmr analysis and computational data. the resulting isolated diterpenes were found to be potent inhibitors of p-glycoprotein ... | 2008 | 18452010 |
| stimulatory effects of euphorbia cheiradenia on cell mediated immunity and humoral antibody synthesis. | studies have demonstrated that plant extracts possess various biological characteristics including immunomodulatory activity. | 2008 | 18523357 |
| the effect of water extracts of euphorbia hirta on cartilage degeneration in arthritic rats. | the effect of water extracts of euphorbia hirta on the histological features and expressions of matrix metalloproteinases (mmps) and tissue inhibitors of matrix metalloproteinases (timps) in the rat articular cartilage was investigated. arthritis was induced in rats using freund's complete adjuvant containing heat-killed m. tuberculosis, and treated with water extracts of e. hirta. paraffin tissue sections of the arthritic joints were evaluated. the extent of cartilage degeneration was found to ... | 2008 | 19291918 |
| activity and structural changes of euphorbia characias peroxidase in the presence of trifluoroethanol. | activity assays, conformational changes and transitional switches between secondary structures of a peroxidase from euphorbia characias were studied in the presence of trifluoroethanol and in the presence or absence of calcium ions. the addition of trifluoroethanol up to 10-20% first induced a drastic decrease of alpha-helix content followed by an increase of tryptophan fluorescence emission intensity, a progressive re-induction of the formation of alpha-helical elements concomitant with loss of ... | 2008 | 19015965 |
| cytotoxic macrocyclic diterpenoids from euphorbia helioscopia. | a new cytotoxic macrocyclic diterpenoid, euphornin l (1), together with seven known analogues were isolated from the plant euphorbia helioscopia l. the structure of 1 was elucidated by spectral data and x-ray crystallographic analysis. euphornin l (1) and euphoscopin f (2) exhibited significant cytotoxicity against hl-60 cell lines with ic(50) values of 2.7 and 9.0 microm, respectively. the 13c-nmr data of euphoscopin f (2), epieuphoscopin b (3), euphoscopin b (5), and euphoscopin c (6) were als ... | 2008 | 19099222 |
| transcriptome analysis identifies novel responses and potential regulatory genes involved in seasonal dormancy transitions of leafy spurge (euphorbia esula l.). | dormancy of buds is a critical developmental process that allows perennial plants to survive extreme seasonal variations in climate. dormancy transitions in underground crown buds of the model herbaceous perennial weed leafy spurge were investigated using a 23 k element cdna microarray. these data represent the first large-scale transcriptome analysis of dormancy in underground buds of an herbaceous perennial species. crown buds collected monthly from august through december, over a five year pe ... | 2008 | 19014493 |
| translocation and accumulation of boron in roots and shoots of plants grown in soils of low boron concentration in turkey's keban pb-zn mining area. | boron (b) concentrations were investigated in both shoots and roots of euphorbia macroclada, verbascum cheiranthifolium, and astragalus gummifer grown in soil of the keban, turkey, lead-zinc-copper-fluoride mining area, which has an arid climate. soil b concentrations were also investigated. plants and their associated soil samples were collected and analyzed by inductively coupled plasma-mass spectrometry (icp-ms). total b concentrations of soils in the study area were very low (mean: 4.97 mg k ... | 2008 | 19260215 |
| anti-tumor 12-deoxyphorbol esters from euphorbia cornigera. | nine (1-8 and 10) new and two (9 and 11) known compounds have been isolated from roots of euphorbia cornigera boiss. their structure and relative stereochemistry were acquired through nmr ((1)h, (13)c, cosy-45, hohaha, hmqc, hmbc, noe and hmbc) spectroscopic measurements. compounds 1-10 were identified as diesters of 13,20-o-diacyl and 11 as 13-o-acetyl of 12-deoxyphorbol. cytotoxic activity of the compounds was investigated on human kb cells by reduction of mtt. compounds 8-10 displayed ic(50) ... | 2008 | 17512094 |
| larvicidal activity of some euphorbiaceae plant extracts against aedes aegypti and culex quinquefasciatus (diptera: culicidae). | larvicidal activity of ethyl acetate, butanol, and petroleum ether extracts of five species of euphorbiaceae plants, jatropha curcas, pedilanthus tithymaloides, phyllanthus amarus, euphorbia hirta, and euphorbia tirucalli, were tested against the early fourth instar larvae of aedes aegypti l. and culex quinquefasciatus (say). the larval mortality was observed after 24 h of exposure. all extracts showed low larvicidal effects; however, the highest larval mortality was found in petroleum ether ext ... | 2008 | 18163189 |
| isolation and identification of mosquito larvicidal compound from abutilon indicum (linn.) sweet. | larvicidal activity of crude hexane, ethyl acetate, petroleum ether, acetone and methanol extracts of five medicinal plants, abutilon indicum, aegle marmelos, euphorbia thymifolia, jatropha gossypifolia and solanum torvum were assayed for their toxicity against the early fourth-instar larvae of culex quinquefasciatus. the larval mortality was observed after 24 h exposure. all extracts showed moderate larvicidal effects; however, the highest larval mortality was found in petroleum ether extract o ... | 2008 | 18176816 |
| removal of lead and cadmium ions from aqueous solution by adsorption onto micro-particles of dry plants. | in the present work, pb(ii) and cd(ii) ion adsorption onto inert organic matter (iom) obtained from ground dried plants: euphorbia echinus, launea arborescens, senecio anthophorbium growing in semi-arid zones of morocco and carpobrotus edulis as the mediterranean plant has been studied. a suspension of plant deroed micro-particles adsorbs lead and cadmium present as ionic species, with a higher affinity for pb(ii). the kinetics and the maximum capacity adsorption depend on the type of plant as w ... | 2008 | 17869071 |
| anthocyanin inhibits propidium iodide dna fluorescence in euphorbia pulcherrima: implications for genome size variation and flow cytometry. | measuring genome size by flow cytometry assumes direct proportionality between nuclear dna staining and dna amount. by 1997 it was recognized that secondary metabolites may affect dna staining, thereby causing inaccuracy. here experiments are reported with poinsettia (euphorbia pulcherrima) with green leaves and red bracts rich in phenolics. | 2008 | 18158306 |
| glyphosate-resistant weeds of south american cropping systems: an overview. | herbicide resistance is an evolutionary event resulting from intense herbicide selection over genetically diverse weed populations. in south america, orchard, cereal and legume cropping systems show a strong dependence on glyphosate to control weeds. the goal of this report is to review the current knowledge on cases of evolved glyphosate-resistant weeds in south american agriculture. the first reports of glyphosate resistance include populations of highly diverse taxa (lolium multiflorum lam., ... | 2008 | 18161884 |
| three new jatrophane polyesters and antiproliferative constituents from euphorbia tuckeyana. | three new jatrophane diterpene polyesters named tuckeyanols a and b and euphotuckeyanol, as well as ten known compounds, helioscopinolides a, b, d and e, naringenin, aromadendrin, coniferaldehyde, 4,20-dideoxy-5-hydroxyphorbol 12,13-diisobutyrate, 4,20-dideoxy-5-hydroxyphorbol 12-benzoate-13-isobutyrate and dehydrodiconiferyl diacetate, were isolated from the methanolic extract of euphorbia tuckeyana. their structures were elucidated by physical and spectroscopic methods including 1 d and 2 d ho ... | 2008 | 18176909 |
| inhibition of quorum sensing-controlled virulence factor production in pseudomonas aeruginosa by south florida plant extracts. | quorum sensing (qs) is a key regulator of virulence and biofilm formation in pseudomonas aeruginosa and other medically relevant bacteria. aqueous extracts of six plants, conocarpus erectus, chamaesyce hypericifolia, callistemon viminalis, bucida buceras, tetrazygia bicolor, and quercus virginiana, were examined in this study for their effects on p. aeruginosa virulence factors and the qs system. c. erectus, b. buceras, and c. viminalis caused a significant inhibition of lasa protease, lasb elas ... | 2008 | 17938186 |
| ingenane diterpenoids from euphorbia esula. | an extensive study of metabolites present in euphorbia esula led to isolation of 16 ingenane diterpenoids 1-16 together with the known ingenane derivative 17 and four known cycloartane triterpenoids. their structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. all the compounds were assayed for their inhibitory activity against human hela cervical cancer cell line. | 2008 | 17976667 |
| bidens pilosa l. exhibits high sensitivity to coumarin in comparison with three other weed species. | nine natural plant compounds were screened for phytotoxicity to bidens pilosa l. a troublesome weed in field and plantation crops. the sensitivity of three other weed species to coumarin, the most active identified compound, was also evaluated. coumarin, at a concentration of 500 microm, had little effect on germination and growth of senna obtusifolia l., euphorbia heterophylla l., and ipomoea grandifolia l. when compared with its effects on b. pilosa l. in a concentration range of 10-100 microm ... | 2008 | 18338136 |
| sexual dimorphism in the andromonoecious euphorbia nicaeensis: effects of gender and inflorescence development. | in andromonoecious taxa with separate floral types along the inflorescence, architectural or plastic effects can simulate floral sexual dimorphism. both the primary and secondary sexual characteristics of the cyathia of the protogynous andromonoecious species euphorbia nicaeensis were analysed according to their sex and arrangement on the inflorescence. | 2008 | 18250109 |
| a new diterpene from the processed roots of euphorbia kansui. | a new diterpene has been isolated from the processed roots of euphorbia kansui. by means of physico-chemical evidences and spectral analysis, the structure was identified as 4-o-acetyl-5-o-benzoyl-3beta-hydroxy-20-deoxyingenol (1). | 2008 | 18253876 |
| physiological changes and molluscicidal effects of crude latex and milin on biomphalaria glabrata. | euphorbian latex is commonly used as molluscicides and the euphorbia milii latex was reported as most powerful molluscicidal agents. the physiological and lethal effects of the latex components of euphorbia milii, on the intermediate host biomphalaria spp., of the human liver parasite schistosoma mansoni were described in this study. the standard methodologies for testing plant derived molluscicides formulated by world health organisation (who) were followed with some modifications. the young sp ... | 2008 | 18262588 |
| differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from adulterants by taqman real-time polymerase chain reaction. | dna sequence analysis of the rdna internal transcribed spacer 1 (its1) and taqman real-time polymerase chain reaction were exploited for their applications in the differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from three related adulterants e. hypericifolia, e. atoto and e. prostrata. the data demonstrated that variations in the its1 regions were very low at the intra-species level but extremely high at the inter-species level, so that they could b ... | 2008 | 18266200 |
| sequential cell wall transformations in response to the induction of a pedicel abscission event in euphorbia pulcherrima (poinsettia). | alterations in the detection of cell wall polysaccharides during an induced abscission event in the pedicel of euphorbia pulcherrima (poinsettia) have been determined using monoclonal antibodies and fourier transform infrared (ft-ir) microspectroscopy. concurrent with the appearance of a morphologically distinct abscission zone (az) on day 5 after induction, a reduction in the detection of the lm5 (1-->4)-beta-d-galactan and lm6 (1-->5)-alpha-l-arabinan epitopes in az cell walls was observed. pr ... | 2008 | 18298669 |
| authentication of the 31 species of toxic and potent chinese materia medica (t/pcmm) by microscopic technique, part 2: three species of seed t/pcmm. | toxic and potent chinese materia medica (t/pcmm) are being used more and more in the treatment of various diseases. in view of their toxic side effects and to ensure their safe use, accurate and reliable authentication is indispensable. however, identifying characteristics of t/pcmm are seldom reported, even though modern microscopy can provide ample, unique identifying characteristics from cells found in transverse sections and powders. in particular, no systematic authentication studies on see ... | 2008 | 18219667 |
| allosteric modulation of euphorbia peroxidase by nickel ions. | a class iii peroxidase, isolated and characterized from the latex of the perennial mediterranean shrub euphorbia characias, contains one ferric iron-protoporphyrin ix pentacoordinated with a histidine 'proximal' ligand as heme prosthetic group. in addition, the purified peroxidase contained 1 mole of endogenous ca(2+) per mole of enzyme, and in the presence of excess ca(2+), the catalytic efficiency was enhanced by three orders of magnitude. the incubation of the native enzyme with ni(2+) causes ... | 2008 | 18266763 |
| cheiradone: a vascular endothelial cell growth factor receptor antagonist. | angiogenesis, the growth of new blood vessels from the pre-existing vasculature is associated with physiological (for example wound healing) and pathological conditions (tumour development). vascular endothelial growth factor (vegf), fibroblast growth factor-2 (fgf-2) and epidermal growth factor (egf) are the major angiogenic regulators. we have identified a natural product (cheiradone) isolated from a euphorbia species which inhibited in vivo and in vitro vegf- stimulated angiogenesis but had n ... | 2008 | 18230134 |
| cytotoxic activity of an octadecenoic acid extract from euphorbia kansui (euphorbiaceae) on human tumour cell strains. | we have investigated the cytotoxic and antitumour activity of an octadecenoic acid extract, mainly containing oleic and linoleic acids, from euphorbia kansui on human gastric (sgc-7901), hepatocellular carcinoma (bel-7402), and leukaemia (hl-60) tumour cell strains. significant and dose-dependent antiproliferation effects were observed on tumour cells from the dose of 3.2 microg ml(-1), which were comparable with or better than those of the common antitumour agent 5-fluorouracil. results from th ... | 2008 | 18237474 |
| spirowallichiione: a rearranged multiflorane from euphorbia wallichii hook f. (euphorbiaceae). | euphorbia wallichii of the family euphorbiaceae yielded a new rearranged pentacyclic triterpene of the multiflorane class which we have named spirowallichiione. the structure of this natural spirocompound was elucidated with the aid of modern spectroscopic techniques, including 2d-nmr. | 2008 | 18305427 |
| isolation and characterization of antagonistic bacteria against bacterial leaf spot of euphorbia pulcherrima. | to investigate the inhibition potential of leaf-associated bacteria against the pathogen of bacterial leaf spot of euphorbia pulcherrima. | 2008 | 18298451 |
| cytotoxic diterpenoids from euphorbia helioscopia. | four new jatrophane-type diterpenoids (1-4), together with 16 known related compounds, were isolated from the chinese medicinal plant euphorbia helioscopia. the structures of 1-4 were determined on the basis of spectroscopic and chemical methods. cytotoxicity of the isolated compounds against hela and mda-mb-231 cells was evaluated, with only helioscopinolide a (5) and euphornin (3a) being active. | 2008 | 18321057 |
| chemical constituents with antibacterial activity from euphorbia sororia. | a group of ceramide (1) was isolated from the aerial parts of euphorbia sororia. on the basis of spectroscopic data, chemical methods and gc-ms analysis, the structure of 1 was characterised as (2s,3s,4r,8e)-2-(eicosanoyl approximately octacosanoyl amino)-1,3,4-octadecanetriol-8-ene. in addition, four known ellagic acid derivatives 3,3'-di-o-methylellagic acid (2), 3,3',4'-tri-o-methylellagic acid (3), 4-o-sulfooxy-3,3'-di-o-methylellagic acid (4) and 4-o-sulfooxy- 3,3',4'-tri-o-methylellagic ac ... | 2008 | 18322851 |
| antileishmanial activity of piceatannol isolated from euphorbia lagascae seeds. | in the search for biologically active compounds from euphorbia lagascae spreng, an herbaceous plant native to southeast of iberic peninsula, a stilbene, two coumarins and two 12-deoxyphorbol diterpene esters were isolated by chromatographic methods, from the methanol extracts of its defatted seeds. the structures of these compounds were elucidated by a combination of physical and spectral data (ir, ms and high-resolution (1)h-nmr and (13)c-nmr spectroscopy utilizing cosy, hmbc, hmqc and noesy ex ... | 2008 | 18167046 |
| electroactive centers in euphorbia latex and lentil seedling amine oxidases. | the electrochemical behavior of redox centers in the active site of amine oxidases from lentil seedlings and euphorbia characias latex was investigated using a mercury film electrode. tyrosine-derived 6-hydroxydopa quinone (tpq) and copper ions in the active site are redox centers of these amine oxidases. the enzymes undergo two reduction processes at negative potentials related to the reduction of the tpq cofactor to the corresponding hydroquinones and the reduction of copper ions, (cu(ii)-->cu ... | 2008 | 18175931 |
| inhibition of mrp1 transport activity by phenolic and terpenic compounds isolated from euphorbia species. | a search for inhibitors of multidrug resistance (mdr)-associated protein 1 (mrp1) was performed among the compounds isolated from euphorbia species, plants traditionally used in folk medicine. | 2007 | 18225583 |
| in vitro anti-helicobacter pylori activity of extracts of selected medicinal plants from north west cameroon. | helicobacter pylori, a gram negative microaerophilic bacterium is a major etiological agent in duodenal, peptic and gastric ulcers. the growing problem of antibiotic resistance by the organism demands the search for novel compounds from plant based sources. | 2007 | 17913416 |
| new mdr modulators and apoptosis inducers from euphorbia species. | several macrocyclic diterpenes with jatrophane or lathyrane skeletons were isolated from methanol extracts of hungarian euphorbia species and evaluated for multidrug resistance (mdr)-reversing activity on a human colon cancer cell line. mdr-reversing activity was tested by using a standard functional assay with rhodamine 123 as a fluorescent substrate analogue of epirubicin. in the model of combination chemotherapy, the interactions between epirubicin and certain resistance modifiers were studie ... | 2007 | 17970094 |
| [poisoning due to tropical spurges: description of two cases]. | 2007 | 17784690 | |
| preliminary identification and coat protein gene phylogenetic relationships of begomoviruses associated with native flora and cultivated plants from the yucatan peninsula of mexico. | a number of native and cultivated eudicots in the yucatan peninsula of mexico (ypm) exhibit symptoms associated with virus infection. symptomatic leaves were collected and assessed for begomoviral detection using polymerase chain reaction (pcr), and universal primers that amplify a fragment of the coat protein gene (core cp). begomovirus were detected in nine native and seven cultivated species, representing seven eudicot families. dna extracts from the 16 hosts were used for pcr amplification a ... | 2007 | 17682933 |
| euphorbia lactea sap keratouveitis: case report and review of the literature. | to describe a case of euphorbia lactea sap keratouveitis and to review all reported cases of ocular toxicity caused by euphorbia species. | 2007 | 17592331 |
| biogenetical related highly oxygenated macrocyclic diterpenes from sea spurge euphorbia paralias. | a new tricyclic diterpenoid, named pre-segetanin (1), and two new diterpenes, named segetanin a and b (2 and 3), the latter based on the rare segetane skeleton, have been identified from the whole plant of sea spurge along with four known segetane diterpenes (4-7). among them, pre-segetanin (1) has an unprecedented carbon skeleton, whose isolation provides a first insight into the biosynthesis of diterpenoids with a segetane skeleton. the stereostructure elucidation of the isolated metabolites w ... | 2007 | 17665924 |