| new highly irritant euphorbia factors from latex of euphorbia tirucalli l. | from the latex of euphorbia tirucalli l. growing in madagascar, 5 new euphorbia factors were isolated. they were characterized as 13-o-acetyl-12-o-acylphorbol- and 12-o-acetyl-13-o-acylphorbol derivatives carrying homologous conjugated unsaturated fatty acids as acyl groups. furthermore, 2 mixtures of homologous 3-o-acylingenol derivatives are obtained carrying the same type of unsaturated fatty acids. due to their highly unsaturated acyl groups all euphorbia factors or factor groups isolated ar ... | 1977 | 891836 |
| dermatitis after exposure to a garden plant (euphorbia myrsinites). | six pediatric cases of erythematous papulovescicular skin eruptions were due to exposure to euphorbia myrsinites. these rashes may be confused with allergies, infections, or other dermatoses. symptoms followed two to eight hours after exposure to the irritant sap, they increased in severity for an additional 12 hours, and they resolved within three to four days. no sequelae were noticed. treatment indicated was pain relief, prevention of infection, and reduction of swelling. | 1979 | 760508 |
| [molluscicidal properties of the euphorbia cotinifolia l (author's transl)]. | the hexanic extract from the leaves of euphorbia cotinifolia l. has been experimentally used as molluscicide against biomphalaria glabrata. the extract was fractionated and the most actives fractions were those of numbers 6 and 7. the lethal concentrations (lc50 and lc90 obtained using fraction 6 against adult snails were 1,2 and 2,4 ppm; for the eggs they were 25,0 and 48,0 ppm. with fraction 7 the lethal concentrations were 1,4 and 3,4 ppm for adult snails; for newly hatched snails they were 4 ... | 1978 | 751112 |
| constituents of egyptian euphorbiaceae. part 6: phytochemical investigation of euphorbia geniculata jacq. and e. prostrata ait. | | 1978 | 724788 |
| candletoxins a and b, 2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, from the irritant latex of euphoria poisonii pax. | 2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, known as candletoxins a and b, were isolated from the irritant latex of euphorbia poisonii pax. compound a was identified as 12-deoxy-phorbol-13-o-phenylacetate-16-o-alpha-methyl-butyrate-20-acetate, and compound b was the c-20 desacetyl analogue. | 1977 | 891875 |
| constituents of egyptian euphorbiaceae iv investigation of euphorbia indica. | | 1977 | 905435 |
| a note on the isolation and identification of two pharmacologically active constituents of euphorbia pilulifera. | | 1978 | 642726 |
| the irritant toxins of blue euphorbia (euphorbia coerulescens haw). | | 1978 | 622726 |
| triterpenes in latex of euphorbia pulcherrima. | | 1977 | 905409 |
| [comparative study of herbal infusions of the spurges, euphorbia seguieriana, e. virgata and e. semivillosa, obtained by different methods]. | | 1978 | 658352 |
| the succulent euphorbias of nigeria. iii. structure and potency of the aromatic ester diterpenes of euphorbia poissonii pax. | the latex of euphorbia poissonii was found to contain irritant aromatic diterpene esters based upon resiniferonol, 12-deoxy-16-hydroxy-phorbol and 12-deoxyphorbol. four resiniferonol esters, 9,13,14-ortho-phenylacetyl-resiniferonol-20-0-[p-hydroxy-phenylacetate]; 9,13,14-orthophenylacetyl-resiniferonol-20-0-[m-methoxy-m'-hydroxy-phenylacetate]; 9,13,14-orthophenylacetyl-resiniferonol-20-0-acetate and resiniferonol-14-0-phenylacetate-20-0-[m-methoxy-m'-hydroxy-phenylacetate], were identified. two ... | 1979 | 506740 |
| [studies on the active principles of ze-qi (euphorbia helioscopia l.), a drug used for chronic bronchitis (i) (author's transl)]. | | 1979 | 506714 |
| cocarcinogenic and irritant factors of euphorbia esula l. latex. | the latex of (euphorbia esula) has been found to contain highly skin irritant and inflammatory ingenol-3delta 2,4,6,8,10 pentene tetradecanoate and another factor, ingenol-3-dodecanoate, which is less irritating but which can be responsible for the cocarcinogenic activity exhibited by the latex preparation in the mice back skin experiment. | 1978 | 653835 |
| gibberellins and the break of bud dormancy in virus-infected stem cuttings of euphorbia pulcherrima. | break in bud dormancy in virus-infected stem cuttings of euphorbia pulcherrima occurs because of the higher quantity of gibberellins present in them than in healthy cuttings in the dormant period of the plant. | 1979 | 499409 |
| flavonoids of euphorbia geniculata and euphorbia prostata. | | 1977 | 594128 |
| crystalline principles of euphorbia terracina l. | | 1977 | 594124 |
| constituents of egyptian euphorbiaceae. vii. further investigation of the flavonoids of euphorbia paralias l. | | 1979 | 461577 |
| euphorbia species. | | 1992 | 1346699 |
| chemical investigation of local plants. part ii. triterpenoids of euphorbia wallichii hk.f. | | 1979 | 419191 |
| [constituents of tannins from euphorbia prostrata ait]. | ten compounds have been isolated from euphorbia prostrata and identified as gallic acid, corilagin, 1,2,3-tri-o-galloyl-d-glucose,geraniin,tellimagradin i, ii, rugosin a, rugosin e, rugosin d and rugosin g on the basis of physicochemical and spectroscopic methods. | 1992 | 1418550 |
| historical note: drumine--a new australian local anaesthetic. | an article in the australiasian medical gazette of october, 1886 indicates the method of extraction, experimentation and therapeutic application of an active principle, prepared from euphorbia drummondii. further correspondence is noted, refining the method of extraction, reporting cases, answering criticisms, and announcing eventually, drumine's commercial preparation. despite enthusiastic support, the drug soon disappears from the therapeutic scene. | 1977 | 320904 |
| skin irritants of euphorbia fortissima. | by means of a combination of partition and chromatographic methods six irritant constituents were isolated from the fresh latex of euphorbia fortissima. compounds a-d were di-esters of the common parent diterpene 12-deoxyphorbol, and compounds e and f were mono-esters of the same diterpene. the fresh latex had an irritant dose 50% (id50) on mice of 0-64 mug mul- minus 1. compounds a-d are short-acting irritants reaching a maximum activity within 4 h of application to the skin, whilst the monoest ... | 1975 | 239133 |
| petty spurge (euphorbia peplus l.). | | 1975 | 233888 |
| on the active principles of the spurge family. iii. skin irritant and cocarcinogenic factors from the caper spurge. | the toxic and irritant principles of the seed oil and of the latex of the caper spurge (euphorbia lathyris l.) were isolated together with several non irritants of similar chemical structure. from the seed oil two irritant euphorbia factors l5 and l6 and from the latex a mixture of irritant euphorbia factors were obtained. euphorbia factor l5 was identified as 3-hexadecanoate of the new tetracyclic, poly-functional diterpene parent alcohol ingenol. euphorbia factor l6 most probably is the 3-tetr ... | 1975 | 128221 |
| specific inhibition of formation of acid-fastness in mycobacteria by 3,3'-di-o-methylellagic acid. | 3,3'-di-o-methylellagic acid obtained from euphorbia adenochlora selectively inhibited the formation of acid-fastness in mycobacteria without retardation of their growth. gross reductions in contents of wax d, cord factor and free mycolic acids were found in the nonacid-fast bacilli compared with the normal ones. | 1979 | 87342 |
| characterization of an irritant 4-deoxyphorbol diester from euphorbia tirucalli. | latex of euphorbia tirucalli, collected in colombia, yielded 12-o-2z-4e-octadienoyl-4-deoxyphorbol-13-acetate (1), which exhibited an irritant potency equivalent to that of the standard irritant, phorbol-12-tetradecanoate-13-acetate, in a mouse ear test system. the unsaturated 4-deoxyphorbol diesters recently reported in e. tirucalli grown in south africa were not observed in the present study. | 1979 | 469552 |
| axenic cultivation of phytomonas davidi lafont (trypanosomatidae), a symbiote of laticiferous plants (euphorbiaceae). | phytomonas davidi (trypanosomatidae) originally discovered by lafont in 1909 on the island of mauritius was rediscovered in euphorbia cyathophora in florida. successful cultures were established in diphasic medium consisting of duck blood agar and modified phillips' medium as overlay. optimal growth was obtained when mansour's medium was used as overlay and poorest growth when cowperthwaite's medium buffered at ph 5.0 was utilized for this purpose. marked changes tending toward choanomastigotes ... | 1976 | 933080 |
| a skin irritant phorbol ester from euphorbia cooperi n e br. | from the fresh latex of euphorbia cooperi n e br was isolated by partition and chromatographic methods, a diterpene ester 12-deoxyphorbol-16-isobutyrate-13-tigliate. the phorbol ester exhibited highly irritant activity on the mouse ear. since skin irritancy is an indication of possible tumour promotion, the use of this plant as a medicine should be discouraged. | 1992 | 1340794 |
| constitutents of egyptian euphorbiaceae. part 2: flavonoids of euphorbia paralias. | | 1976 | 959303 |
| isolation of ingenol from the irritant and cocarcinogenic latex of euphorbia seguieriana. | | 1976 | 959388 |
| tumor promoting constituent of euphorbia serrata l. latex. | euphorbia serrata latex has initially ingenol-3-palmitate, which by action of silica gel is converted to ingenol-20-palmitate. the former is responsible for the irritant and cocarcinogenic activity of the latex on mouse ear and on mice back skin. | 1976 | 971764 |
| home treatment of basal cell carcinoma. | the sap of the plant euphorbia peplus is not uncommonly used as a home treatment for warts and basal cell carcinomas. this report documents its successful use on a biopsy-proven basal cell carcinoma. | 1976 | 979751 |
| irritant constituents of iranian plants. ingenol from euphorbia seguieriana. | | 1976 | 981395 |
| [antibacterial activity of preparations from the spurges, euphorbia seguieriana neck., e. virgultosa klok. and e. semivilliosa prokh]. | | 1979 | 456524 |
| a comparative study of antigens of aspergillus fumigatus isolates from patients and soil of ornamental plants in the immunodiffusion test. | the strikingly frequent and constant presence of aspergillus fimigatus in the soil of potted ornamental plants kept in private houses and hospitals has been the reason for studying the antigens of the strains found from the diagnostic and epidemiological angles. culture-filtrate antigens of a. fumigatus strains isolated from the soil of 4 different ornamental plants, epiphyllum (epiphyllum truncatum), orange tree (citrus sinensis), alpine rose (azalea indica) and christmas flower (euphorbia pulc ... | 1978 | 83753 |
| phytochemical study of euphorbia paralias. | | 1976 | 948535 |
| a biological screen of selected species of the genus euphorbia for skin irritant effects. | | 1975 | 1208681 |
| phytochemical study of euphorbia peplus. | | 1975 | 1161908 |
| spectrophotometric estimation of individual flavone glycosides in three euphorbia species. | two spectrophotometric methods (conventional and differential) are carried out for the estimation of flavone glycosides (hyperoside and/or kaempferol-3-beta-glucoside) in euphorbia paralias l., and euphorbia helioscopia l. the glycosides are extracted with methanol from the aerial parts of the different euphorbia species, separated on silica gel chromatoplates, and eluted by refluxing with methanol (80%). the absorbance value (conventional method) and the delta absorbance value (differential met ... | 1975 | 1161795 |
| [flavonol glycosides from euphorbia helioscopia, e. stricta, e. verrucosa and e. dulcis (author's transl)]. | | 1975 | 1161897 |
| [occupational allergy due to inhalation of pollen from euphorbia fulgens karw (author's transl)]. | the increased cultivation and sales of euphorbia fulgens karw., originating in mexico, has in the last few years led to occupational allergy, type i, in three growers manifesting itself as nasal disease, tracheobronchitis or bronchial asthma. intracutaneous tests with pollen extracts were positive in all cases, even at high dilution. a specific hyposensitisation regimen, conducted over five months, gave highly promising results in one patient who had no symptoms in the following season, despite ... | 1976 | 1261372 |
| evaluation of the molluscicidal properties of euphorbia splendens var. hislopii (n. e. b.) (euphorbiaceae)--1. experimental test in a lentic habitat. | the latex of euphorbia splendens var. hislopii, at concentrations between 5 to 12 mg/l, kills 100% of the population of biomphalaria glabrata in a lentic habitat, after 24 h. the lyophilized latex, stocked for 18 months, killed only 34.2% of the snails, at the concentration of 5 mg/l, and 96.0% at 12 mg/l. no lethal effect was observed among pomacea haustrum exposed to the same concentrations of the molluscicide. | 1992 | 1308551 |
| evaluation of temporal, seasonal and geographic stability of the molluscicidal property of euphorbia splendens latex. | laboratory tests with aqueous solutions of euphorbia splendens var. hislopii latex have demonstrated seasonal stability of the molluscacidal principle, with ld90 values of 1.14 ppm (spring), 1.02 ppm (fall), 1.09 ppm (winter), and 1.07 ppm (summer) that have been determined against biomphalaria tenagophila in the field. assays on latex collected in belo horizonte and recife yielded ld90 values similar to those obtained with the reference substance collected in rio de janeiro (ilha do governador) ... | 1992 | 1342068 |
| stimulatory effects of ingenols from euphorbia kansui on the expression of macrophage fc receptor. | immune complex binding to macrophages was enhanced by treatment with an e. kansui extract. systematic fractionation of the extract led to the characterization of 3-o-(2'e,4'z-decadienoyl)- and 3-o-(2,3-dimethylbutyryl)-13- o-n-dodecanoyl-13-hydroxyingenol as the active principles. immune complex binding to macrophages by the action of these compounds increased in a dose-dependent manner. when each ingenol (10 nm) was added to the separated culture medium, the immune complex binding ability of ma ... | 1992 | 1409980 |
| characterization of carbohydrate metabolism and demonstration of glycosomes in a phytomonas sp. isolated from euphorbia characias. | phytomonas sp. isolated from euphorbia characias was adapted to sdm-79 medium. cells isolated in the early stationary phase of growth were analyzed for their capacity to utilize plant carbohydrates for their energy requirements. the cellulose-degrading enzymes amylase, amylomaltase, invertase, carboxymethylcellulase, and the pectin-degrading enzymes polygalacturonase and oligo-d-galactosiduronate lyase were present in phytomonas sp. and were all, except for amylomaltase, excreted into the extern ... | 1992 | 1435859 |
| [triterpene constituents from euphorbia nematocypha hand-mazz]. | seven triterpenoids have been isolated from the roots of euphorbia nematocypha hand-mazz. through chromatography on 20% agno3-silica gel. one of them was identified as a new compound named nematocyphol on the basis of spectral data (ir, eims, 1h-nmr and 13c-nmr). its structure was deduced as iva. other compounds were identified as nepehinol acetate (i), germanicol acetate (ii), euphol (iii), tanaxastanol (va), 24-methylenecycloartanol (via) and nepehinol (viia). these compounds were obtained for ... | 1992 | 1442072 |
| [purification of lipase from latex of euphorbia characias by an extraction method with apolar solvent]. | a lipase from the latex of euphorbia characias was purified using a new method involving extraction by apolar solvent and adsorption chromatography on silica. the lipase (specific activity 1,500 iu/mg of protein) was eluted from silica complexed with a lipid. the main proteic fraction, showing a molecular weight of 38,000, was inactive when dissociated from the lipid fraction. it was necessary to reassociate the lipid and proteic fractions for 72% of the lipolytic activity to be recovered. | 1992 | 1617480 |
| evaluation of the genotoxic activity and acute toxicity of euphorbia splendens latex, a molluscicide for the control of schistosomiasis. | 1. the latex of euphorbia splendens var. hislopii has a molluscicidal action at low concentration (ld90 less than 1.5 ppm or 1.5 micrograms/ml) against the vector snails of schistosomiasis. 2. in the present study, the latex in natura or after lyophilization was submitted to the ames test and the chromotest to evaluate genotoxicity, to the microtox system to determine acute toxicity, and to the chinese hamster ovary cell assay (cho) to measure cytotoxicity. 3. the latex had no mutagenic activity ... | 1991 | 1823273 |
| irritant contact dermatitis from euphorbia marginata. | | 1991 | 1828219 |
| toxicological study of the molluscicidal latex of euphorbia splendens: irritant action on skin and eye. | aqueous solutions of the molluscicidal latex of euphorbia splendens are irritant to the rabbit eye in concentrations higher than 0.35% and to the rabbit skin in concentrations higher than 0.5%. although this irritant potential does not preclude its use as a molluscicide, special precautions are recommended for handling and application of the product and the hazard of skin tumor-promoting potential should be carefully investigated before its use for schistosomiasis vector control. | 1991 | 1842019 |
| analgesic, antipyretic and anti-inflammatory properties of euphorbia hirta. | lyophilised aqueous extract of euphorbia hirta l. (euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedative effect, associated with anxiolytic effects. this study leads us to the conclusion that this plant extract exerts central analgesic properties. such a dose-dependent action was o ... | 1991 | 1896520 |
| antitumor agents, 119. kansuiphorins a and b, two novel antileukemic diterpene esters from euphorbia kansui. | the extract of the roots of euphorbia kansui, which has been widely used in chinese folk medicine for the treatment of cancer, demonstrated antileukemic activity against the p-388 lymphocytic leukemia in mice. bioassay-directed fractionation of the active extract led to the isolation and characterization of two novel antileukemic diterpene esters, kansuiphorin a [1] [13-hydroxyingenol-3-(2,3-dimethylbutanoate)-13-dodecanoate- 20- hexadecanoate] and kansuiphorin b [2] [6,7-epoxy-13-hydroxyingenol ... | 1991 | 1955882 |
| behavioral effects of euphorbia hirta l.: sedative and anxiolytic properties. | lyophilised aqueous extract of euphorbia hirta l. (euphorbiaceae) has been evaluated for behavioral effects in mice. the extract did not induce any toxic effect when it was administered i.p. and orally. sedative properties could be confirmed with high doses (100 mg of dried plant/kg, and more), by a decrease of behavioral parameters measured in non-familiar environment tests (activitest and staircase test), whereas anticonflict effects appeared at lower doses (12.5 and 25 mg of dried plant/kg), ... | 1990 | 1973750 |
| [clinical and experimental study on the treatment of children diarrhea by granule of children-diarrhea fast-stopping]. | granule of children-diarrhea fast-stopping is a proved recipe composed of seven medical herbs such as poria cocos, haw charcoal, euphorbia humifusa, etc. after more 20 years' clinical application of 419 cases, the total effective rate proved to be 96.4% and the cure rate 90%, much better than the control groups [tcm: gelian san and shenglingbaizhu san; wm: gentamycin and ppa]. it had the effect of fast-stopping diarrhea and shortening the recovery period. it also had excellent curative effect fo ... | 1991 | 2060055 |
| protein bodies in the nucellus of euphorbia helioscopia. | | 1976 | 1249847 |
| topical antiinflammatory effects of euphorbia prostrata on carrageenan-induced footpad oedema in mice. | the ethyl acetate extract and a fraction, kse-23, isolated chromatographically from the ethyl acetate extract of euphorbia prostrata, showed significant antiinflammatory activity when topically applied in a murine model of carrageenan footpad oedema. kse-23 was found to be more potent than indomethacin given in the same manner. | 1990 | 2214815 |
| hepatoprotective compounds from canarium album and euphorbia nematocypha. | successive purification of the extract from canarium album and euphorbia nematocypha, guided by antihepatotoxic activity in primary cultured rat hepatocytes, led to the isolation of brevifolin (1), hyperin (2), ellagic acid (3) and 3,3'-di-o-methylellagic acid (4) as hepatoprotective compounds. compounds 1,3 and 4 also reduced carbon tetrachloride (ccl4)-induced liver damage in mice. the hepatoprotective activities of 1, 2, 3 and 4 in vitro and in vivo are apparently due to their antioxidative e ... | 1990 | 2279282 |
| comparative study of the surface charge of some isolates of trypanosomatids of the genus phytomonas. | the surface charge of different isolates of phytomonas from euphorbia hyssopifolia, euphorbia pinea, euphorbia characias and manihot esculenta was analysed by the binding of cationic particles (colloidal iron hydroxide at ph 1.8 and cationized ferritin at ph 7.2) to the protozoan surface and by determination of the cell electrophoretic mobility (epm). all the isolates had a net negative surface charge, and the isolate from e. hyssopifolia manifested the greatest negative charge. a good relations ... | 1989 | 2517559 |
| anti-inflammatory studies on euphorbia prostrata. | anti-inflammatory studies were conducted in rats on an ethanol extract of whole plant euphorbia prostrata and its partitioned fractions. the ethyl acetate fraction in an oral dose of 200 mg/kg, inhibited 76% of acute carrageenan-induced paw edema. a fraction, labelled as kse-23, isolated from the ethyl acetate fraction inhibited 57% of pedal edema at a dose of 8 mg/kg. acute inflammatory studies of fractions using histamine and bradykinin-induced pedal edema indicated a selective inhibition of h ... | 1989 | 2615426 |
| an antitumor principle from euphorbia lathyris. | the extract of seeds of euphorbia lathyris l. showed antitumor activity against sarcoma 180 ascites in mice. systematic fractionation of the extract led to the characterization of ingenol-3-hexadecanoate as an active principle, together with an inactive diterpene ingenol-20-hexadecanoate. | 1989 | 2740459 |
| resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. | resiniferatoxin is an extremely irritant diterpene present in the latex of several members of the genus euphorbia. its mechanism of action has been shown to be clearly distinct from that of the structurally related phorbol esters. since resiniferatoxin possesses a 4-hydroxy-3-methoxyphenyl substituent, a key feature of capsaicin, the major pungent ingredient of plants of the genus capsicum, we examined the ability of resiniferatoxin to induce typical capsaicin responses. we report here that trea ... | 1989 | 2747924 |
| proceedings: a screening procedure for euphorbia co-carcinogenic irritants. | | 1973 | 4150549 |
| screening extracts of euphorbia garuana n.e.br. for in-vitro cytotoxicity. | two biological assays utilising in-vitro uptake of 3h-thymidine into tlx/5 lymphoma and rat basophilic leukaemia cells have been used for rapid detection and subsequent isolation of active compounds from the latex of euphorbia garuana (euphorbiaceae). two potent esters were characterized from the latex of e. garuana reportedly used in traditional medicine for the treatment of certain forms of cancer. | 1988 | 2854369 |
| chromosome translocation and c-myc activation by epstein-barr virus and euphorbia tirucalli in b lymphocytes. | dual exposure to epstein-barr virus and purified 4-deoxyphorbol ester derived from the plant euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human b lymphocytes in vitro. rearrangements most commonly affected chromosome 8, the chromosome most often showing structural changes in burkitt's lymphoma (bl) cells. e tirucalli is indigenous in parts of africa where bl is endemic and may be an important risk factor for the disease. | 1991 | 1673740 |
| use of an amoeba proteus model for in vitro cytotoxicity testing in phytochemical research. application to euphorbia hirta extracts. | amoeba proteus is proposed as a low-cost multi-purpose biochemical tool for screening and standardizing cytotoxic plant extracts with possible application in the laboratories of developing countries. advantages and limitations of this test are examined and different mathematical treatments (probit analysis versus curve fitting to von bertalanffy and hill functions) are investigated. known anti-cancer (doxorubicin, daunorubicin, dacarbazine, 5-fluorouracil) and antiparasitic (emetine, dehydroemet ... | 1991 | 1686625 |
| [m-hydroxyphenylglycine and 3,5-dihydroxyphenylglycine, 2 new amino acids from the latex of euphorbia helioscopia l]. | | 1968 | 4385921 |
| similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons. | we have compared the ability of capsaicin and resiniferatoxin, a natural diterpene present in the latex of plants of the euphorbia family to excite and desensitize capsaicin-sensitive primary afferents in a variety of models. both capsaicin and resiniferatoxin inhibited the twitch contractions of the rat isolated vas deferens and prevented, in a concentration-related manner, the effect of a subsequent challenge with 1 microm capsaicin (desensitization). resiniferatoxin was 1000-10,000 times more ... | 1990 | 1723514 |
| activity on the cns of crude extracts and of some diterpenoids isolated from euphorbia calyptrata suspended cultures. | crude methanolic extracts from both root and cell cultures of euphorbia calyptrata were investigated and found to be active on the cns. an active fraction was isolated from the methanolic extract of suspension cultures; this possesses significant depressant activity on the cns. when compared with the crude methanolic root extract, this fraction showed the presence of some common products, four of which were isolated and characterized as helioscopinolides a, c, d, and e. the pure products, admini ... | 1991 | 1818344 |
| [quercetin derivatives of euphorbia lucida w.k]. | | 1975 | 1211210 |
| antibacterial activity of euphorbia thymifolia linn. | | 1988 | 3169896 |
| [isolation and identification of antitumor constituents of diterpenoids lactone in euphorbia fischeriana steud]. | | 1988 | 3197209 |
| antileukemic principles isolated from euphorbiaceae plants. | extracts of euphorbia esula l. and croton tiglium l., two members of the euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the p-388 lymphocytic leukemia in mice. systematic fractionation of the extract of euphorbia esula l. led to characterization of a major antileukemic component as the new diterpenoid diester, ingenol 3,20-dibenzoate. similar fractionation of croton oil led to characterization of phorbol 12-tiglate 13-decanoa ... | 1976 | 1251193 |
| [isolation and identification of the lipophilic constituents from the root of euphorbia fischeriana steud]. | | 1987 | 3442914 |
| 3,3',5'-tri-o-methylpiceatannol and 4,3',5'-tri-o-methylpiceatannol: improvements over piceatannol in bioactivity. | piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) (nsc 365798) has recently been isolated and was subsequently synthesized for nci tumor panel testing as a new antileukemic natural product from the seeds of euphorbia lagascae. during the synthesis, a bioactive reaction mixture of several partially o-methylated piceatannol analogues was obtained. this mixture has now been maximized and subjected to bioactivity-directed fractionation, using brine shrimp lethality, to yield 3,3',5'-tri-o-methylpi ... | 1987 | 3598597 |
| latex of "coroa de cristo" (euphorbia splendens): an effective molluscicide. | an aqueous solution of the latex of "coroa de cristo" (euphorbia splendens var. hislopii) showed molluscicide action (ld90) at a concentration lower than 0.5 ppm on biomphalaria glabrata and b. tenagophila reared in laboratory and at a concentration lower than 4.0 ppm for field b. tenagophila. | 1986 | 3613981 |
| [euphorbia and high chapparall--hazardous pot plants in fashion]. | | 1986 | 3747661 |
| contact dermatitis from euphorbia pulcherrima. | | 1985 | 3161691 |
| molluscicide activity of the "avelós" plant (euphorbia tirucalli, l.) on biomphalaria glabrata, the mollusc vector of schistosomiasis. | an aqueous solution of the latex of euphorbia tirucalli collected at sites receiving large amounts of sunlight showed molluscicide action on biomphalaria glabrata, with ld50 obtained at the concentration of 28,0 ppm and ld90 at the concentration of 85,0 ppm. the toxicity of the product for fish was similar to that of bayluscide and of copper sulfate used for comparison. however, the wide distribution of the plant, its easy propagation and the simple procedure for extraction of the active substan ... | 1985 | 3939311 |
| [euphorbiae keratoconjunctivitis]. | this paper reports on 6 cases of keratoconjunctivitis caused by the latex of euphorbiaceae, one of them with slight systemic intoxication. phorbolesters are considered to be responsible for the toxicity of the latex of euphorbiaceae, e.g., in the case of euphorbia helioscopia, 12-desoxyphorbol-13-phenylacetate-2-o-acetate. since all of the cases of keratoconjunctivitis euphorbiae described here, as well as the majority of those cited in the literature, have resulted in a restitutio ad integrum, ... | 1985 | 4021430 |
| irritant dermatitis due to euphorbia marginata. | | 1985 | 4042646 |
| on the active principles of the spurge family (euphorbiaceae). xi. [1] the skin irritant and tumor promoting diterpene esters of euphorbia tirucalli l. originating from south africa. | the irritant and tumor-promoting constituents of latex of euphorbia tirucalli l. originating from south africa were isolated. they were identified as irritant ingenane and tigliane type diterpene esters derived from unsaturated aliphatic acids and acetic acid and the polyfunctional diterpene parent alcohols 4-deoxyphorbol, phorbol and ingenol, respectively. the irritant and tumor-promoting esters of 4-deoxyphorbol are predominant and were fully characterized chemically and biologically. they are ... | 1985 | 4082727 |
| further new diterpene esters from the irritant and cocarcinogenic seed oil and latex of the caper spurge (euphorbia lathyris l.). | | 1971 | 5144835 |
| [on the biologically active compounds of euphorbiaceae. i. skinirritant and cocarcinogenic factors from euphorbia cooperi n.e.br (author's transl)]. | | 1973 | 4273892 |
| constituents of egyptian euphorbiaceae. i. triterpenoids and related substances of euphorbia paralias. | | 1974 | 4278041 |
| african burkitt's lymphoma and an epstein-barr virus-enhancing plant euphorbia tirucalli. | | 1987 | 2884382 |
| thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin. | resiniferatoxin, an extremely irritant diterpene present in several members of the genus euphorbia, produced an 8 c decrease in the rectal temperature of mice with an effective dose in the range of 2-20 micrograms/kg. the structurally related natural product capsaicin produced a similar magnitude of fall in body temperature, albeit with 1000-fold lower potency. tolerance to the hypothermic effects of both compounds readily developed and cross-tolerance between the compounds was observed. the ext ... | 1989 | 2927241 |
| [mutagenic evaluation of the chinese drug c, l, t, g pill consisting of daphne genkwa, euphorbia kansui, euphorbia pekinensis, glycyrrhiza uralensis tested in salmonella typhimurium and b. subtilis]. | | 1986 | 2952328 |
| [note on 2 african drugs with confirmed amebicidal properties: holarrhens floribunda and euphorbia hirta]. | | 1969 | 5399292 |
| tumor-promoting compounds from euphorbia cooperi di- and triesters of 16-hydroxy-12-desoxy-phorbol. | | 1970 | 5417593 |
| 3-methylquercetin is a potent and selective inhibitor of poliovirus rna synthesis. | 3-methylquercetin (3mq) is a natural compound isolated from euphorbia grantii that selectively inhibits poliovirus replication, but has no effect on encephalomyocarditis virus. when the compound is present from the beginning of infection, the bulk of viral protein synthesis is prevented, but the shut-off of host protein synthesis still occurs. addition of 3mq 3 hr after infection has a slight effect on viral protein synthesis, suggesting that this compound blocks a step of viral replication diff ... | 1986 | 3012868 |
| epstein-barr virus-enhancing plant promoters in east africa. | the extracts of a certain african plant species, euphorbia tirucalli, were found to have markedly enhancing effects on the activation of latent epstein-barr virus (ebv) genomes in the ebv carrying lymphoblastoid cells and also on ebv-induced transformation of human lymphocytes. the euphorbia tirucalli was especially noticeable in highly endemic areas of burkitt's lymphoma (bl), an ebv-associated malignancy, in kenya and tanzania. the activation of the latent ebv genome and the ebv-induced transf ... | 1986 | 3030344 |
| mass spectrometric determination of the inorganic carbon species assimilated by photoautotrophic cells of euphorbia characias l. | the chemical forms of inorganic carbon, co2 or hco3-, incorporated during photosynthesis in photoautotrophic euphorbia characias cell suspension cultures were determined in experiments using 13co2 and a mass spectrometry technique. from the equations of the co2 hydration reaction, a kinetic model was first developed, and the effect of photosynthesis on the external co2 concentration was simulated. it was predicted from this model that co2 and hco3- uptakes could be differentiated by recording on ... | 1988 | 3137227 |
| [on the active principles of the spurge family. ii. skin irritant and cocarcinogenic factors from euphorbia triangularis desf. (author's transl)]. | | 1974 | 4279515 |
| irritant principles of the spurge family (euphorbiaceae). xiii. oligocyclic and macrocyclic diterpene esters from latices of some euphorbia species utilized as source plants of honey. | the latices of the three south african species euphorbia ledienii, euphorbia coerulescens, and euphorbia triangularis, belonging to a group of cactiform euphorbias locally called "noors," were shown to contain four 12-mono- and three 13,20-diesters of the tetracyclic tigliane type parent alcohol 12-deoxyphorbol [1]. in addition, two 13,16-di- and two 13,16,20-triesters of the related 12-deoxy-16-hydroxyphorbol [9] were obtained. ester groups in 1 and 9 are made up of acetic, isobutyric, tiglic, ... | 1988 | 3236005 |
| [polyphenols from leaves of euphorbia hirta l]. | six compounds have been isolated from the leaves of euphorbia hirta and identified as gallic acid, quercitrin, myricitriu, 3,4-di-o-galloylquinic acid, 2,4,6-tri-o-galloyl-d-glucose and 1,2,3,4, 6-penta-o-galloyl-beta-d-glucose on the basis of physicochemical and spectroscopic methods. | 1991 | 2069701 |
| on the active principles of the euphorbiaceae, xii. highly unsaturated irritant diterpene esters from euphorbia tirucalli originating from madagascar. | the latex of euphorbia tirucalli originating from madagascar contains as irritant constituents ingenane- and tigliane-type diterpene esters derived from the parent alcohols ingenol and phorbol. the main irritant constituents are isomeric 12,13-acetates, acylates of phorbol as well as 3-acylates of ingenol. as acyl groups, they carry homologous, highly unsaturated aliphatic acids of the general structure ch3-(ch2)m-(ch = ch)n-cooh (m = 2,4; n = 2,3,4,5; total number n of c-atoms = 2n + m + 2). th ... | 1986 | 3760879 |
| ecological aspects of the jos plateau, nigeria. | the jos plateau has an area of about 6 700 km(2), lies at 1 280 m above sea level, and contains approximately 1 million inhabitants. annual rainfall averaged 137 cm in the period 1965-68; in 1969 rainfall totalled 170 cm and lasted for a month longer than usual.the rural population is engaged in agriculture, tin mining, and cattle grazing. animal life consists chiefly of domestic species; there are few large wild animals. wild primates are apparently rare, although baboons and red patas monkeys ... | 1972 | 4538036 |
| [1-methyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in the milky juice of euphorbia myrsinites l]. | | 1968 | 4386046 |
| tumor promoting compounds from euphorbia triangularis: mono- and diesters of 12-desoxy-phorbol. | | 1969 | 5820946 |
| chemical examination of euphorbia tinctoria boiss. | | 1974 | 4421022 |