Publications

inactivated mycobacterium phlei inhalation ameliorates allergic asthma through modulating the balance of cd4+cd25+ regulatory t and th17 cells in mice.	th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. to address this point, the effect of nebulized inhalation of inactivated mycobacterium phlei on modulation of asthmatic airway inflammation was investigated.	2016	27803782
the effect of inhaled inactived mycobacterium phlei as a treatment for asthma.	allergic asthma is a chronic airway disorder characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (ahr). a murine model of asthma was used to examine the antiasthmatic effect of inhaled inactived mycobacterium phlei (m. phlei). ahr, neutrophil levels, eosinophil levels and levels of interleukin (il)‑17 and il‑23 receptor (il‑23r) were monitored. the results demonstrated that inactivated m. phlei alleviates the il‑17+γδt cell‑mediated immune response and atte ...	2017	28035388
detection of mycobacterium avium subsp. paratuberculosis in cattle by using indirect absorbed elisa (enzyme-linked immunosorbent assay) system and culture in alborz province, iran.	mycobacterium avium subsp. paratuberculosis is a slow growing, gram-positive, and acid-fast bacillus. it is the causative agent of the chronic enteritis disease of ruminants called johne's disease. most of the infected animals are young. however, most clinical cases belong to adult cattle aged 3-5years. due to a prolonged incubation period, identification of subclinically infected animals is one of the most crucial problems in johne's disease. the aim of this study was to detect m. avium subsp. ...	2016	28043567
"mycobacterium massilipolynesiensis" sp. nov., a rapidly-growing mycobacterium of medical interest related to mycobacterium phlei.	in french polynesia, respiratory tract clinical isolate m26, displayed unusual phenotype and contradictory phylogenetic affiliations, suggesting a hitherto unidentified rapidly-growing mycobacterium species. the phenotype of strain m26 was further characterized and its genome sequenced. strain m26 genome consists in a 5,732,017-bp circular chromosome with a g + c% of 67.54%, comprising 5,500 protein-coding genes and 52 rna genes (including two copies of the 16 s rrna gene). one region coding for ...	2017	28074866
efficacy of mycobacterium phlei cell wall-nucleic acid complex (mcna) in bcg-unresponsive patients.	background: we have previously reported the results of a prospective multi-institutional study on the efficacy of mcna in patients who recurred after intravesical bcg treatment [1]. since that publication, a new standardized definition for bcg-unresponsiveness has been established [2]. objective: we re-analyzed the oncologic outcomes following intravesical mcna in patients classified as bcg-unresponsive according to the new definition. methods: for this analysis, we focused on the enrolled patie ...	2017	28149937
the antituberculosis drug ethambutol selectively blocks apical growth in cmn group bacteria.	members of the genus mycobacterium are the most prevalent cause of infectious diseases. mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (magp) is conserved among all cmn group bacteria. the arabinogalactan and mycolic acid synthesis pathways constitute effective drug targets for tuberculosis treatment. ethambutol (emb), a classical antit ...	2017	28174310
immunogenicity and therapeutic effects of recombinant ag85ab fusion protein vaccines in mice infected with mycobacterium tuberculosis.	the immune function of tuberculosis (tb) patients is disordered. by using immune regulators to assist chemotherapy for tb the curative effect might be improved. in this study, a vaccine containing mycobacterium tuberculosis (m. tuberculosis) recombinant ag85ab fusion protein (rag85ab) was constructed and evaluated. the mice were immunized intramuscularly three times at two-week intervals with ag85ab fusion protein combined with corynebacterium parvum adjuvant (rag85ab+cp). in comparison to contr ...	2017	28625522
enzymatic phosphorylation of mannose by glucomannokinase from mycobacterium phlei using inorganic polyphosphate.	mannose-6-phosphate is an important phosphor-sugar, which is involved in many physiological functions and it is used to treat many diseases. its production is however expensive since it requires costly substrate atp as phosphorylation agent. this study has focused upon the direct synthesis of m6p by glucomannokinase using inorganic polyphosphate without involvement of atp. the gene cloned for glucomannokinase has been sequenced from mycobacterium phlei and it is transformed into escherichia coli ...	2017	28648175