| structural elucidation of the major phenolic glycolipid from mycobacterium kansasii. i. evidence for tetrasaccharide structure of the oligosaccharide moiety. | data from the literature indicate the presence, in the mycobacterium kansasii wall, of a phenolic glycolipid called mycoside a. a tentative trisaccharide structure was proposed for the oligosaccharide part, whereas the aglycone was found to correspond to a phenol phthiocerol residue esterified by two mycocerosic acids. in the present work, structural information mainly arising from fast atom bombardment-mass spectrometry, tandem mass spectrometry, and 1h nmr of native and chemically degraded phe ... | 1987 | 3818637 |
| [case of disseminated mycobacterium kansasii infection]. | | 1983 | 6645134 |
| [mycobacterium kansasii as a pathogen in extensive cavitation of the right anterior lobe in a 13-year-old girl]. | | 1983 | 6647282 |
| structural elucidation of the major phenolic glycolipid from mycobacterium kansasii. ii. presence of a novel dideoxyhexose. | a novel o-methyl-2,6-dideoxyhexose was isolated from the major phenolic glycolipid (previously called mycoside a) of mycobacterium kansasii. its molecular weight (162) was determined by gas chromatography-mass spectrometry analysis (chemical ionization with ammonia as reactant gas) of its underivatized reducing form. the methoxyl group was located by electron impact-mass spectrometry of its alditol acetate. the configuration was established by 1h nmr of its peracetylated derivative. the structur ... | 1987 | 3818638 |
| enzyme-linked immunosorbent assay of glycolipid antigens for identification of mycobacteria. | enzyme-linked immunosorbent assays which are based on species- or type-specific glycolipids antigens and in which rabbit antisera are prepared with homologous strains are capable of distinguishing among serological variants of the mycobacterium avium-mycobacterium intracellulare-mycobacterium scrofulaceum complex, mycobacterium chelonei subspecies chelonei and abscessus, mycobacterium simiae i and ii, mycobacterium kansasii, mycobacterium szulgai, mycobacterium xenopi, and mycobacterium fortuitu ... | 1985 | 3886692 |
| periodic acid-schiff reaction stains mycobacterium tuberculosis, mycobacterium leprae, mycobacterium ulcerans, mycobacterium chelonei (abscessus), and mycobacterium kansasii. | | 1985 | 3925927 |
| infection and colonisation by mycobacterium kansasii and mycobacterium xenopi: aerosols as a possible source? | | 1984 | 6725968 |
| in vitro studies of cell-mediated immunity in rabbits sensitized with mycobacterium kansasii and mycobacterium tuberculosis. | rabbits, sensitized with m. kansasii, responded by a profound inhibition of migration of macrophages elicited by both antigens: the migration index for homologous antigen was 0.51 in the direct test and 0.65 in the indirect test; for heterologous antigen the indexes were 0.53 and 0.67. however, significant differences in reactivity were found in rabbits sensitized with m. tuberculosis. in the homologous system, high reactivity was maintained and the migration index reached the value of 0.53 in t ... | 1980 | 6772530 |
| possible role of mycobacteria in inflammatory bowel disease. ii. mycobacterial antibodies in crohn's disease. | an unclassified mycobacterium species has been isolated from two patients with crohn's disease (cd). antibodies to the unclassified mycobacteria cross-reacted with mycobacterium paratuberculosis. because of this cross-reactivity, an enzyme-linked immunosorbent assay (elisa) was used to examine the sera of inflammatory bowel disease (ibd) patients, both cd (n = 56), and ulcerative colitis (uc) (n = 34), for antibodies to m. paratuberculosis, mycobacterium kansasii, and mycobacterium tuberculosis. ... | 1984 | 6437775 |
| systemic mycobacterium kansasii infection and regulation of the alloantigenic response. | specific-pathogen-free b6d2 f1 hybrid mice were infected intravenously with 10(7) to 10(8) viable mycobacterium kansasii cells. the growth of the five test strains in vivo was correlated with the level of delayed hypersensitivity to a cytoplasmic protein antigen injected into the footpad. m. kansasii tmc no. 1201 and 1203 gave rise to persisting systemic infections with an early delayed hypersensitivity response (day 7) followed by a profound anergy to the cytoplasmic protein antigen injections. ... | 1981 | 6454661 |
| suppressor and helper t-cell populations in mycobacterium kansasii-infected spleens. | specific pathogen-free b6d2 f1 hybrid mice were infected intravenously with increasing numbers of mycobacterium kansasii tmc 1203 or 1214 and blastogenic responsiveness of the splenic t cells to phytohaemagglutinin (pha), con a or to a mixed lymphocyte reaction (mlr) were compared. mice which had been infected 30 days earlier with m. kansasii strain 1203 exhibited substantial suppression whereas those infected with 1214 showed enhanced tritiated thymidine uptakes when exposed to mitogenic or all ... | 1981 | 6459287 |
| the histologic spectrum of the cutaneous mycobacterioses. | the authors examined the histopathology of cutaneous involvement in 31 cases of nonleprous mycobacterial infection. cases include three patients with mycobacterium kansasii infection, two with m. fortuitum infections, and one each with m. marinum and m. chelonei infections, as well as 18 with m. tuberculosis infections. in the remainder, species were not identified. the histopathologic picture was variable and often did not suggest mycobacterosis. the authors identified seven basic pathologic pa ... | 1982 | 6804365 |
| immune responsiveness in mice heavily infected with mycobacterium kansasii. | growth of mycobacterium kansasii tmc 1203 in b6d2 f1 hybrid mice was associated with increased splenic cellular proliferation, hyperplasia and the generation of non-specific antibacterial resistance. both responses were dose dependent; the larger the inoculum, the more rapid and extensive the cellular response. however, such mice were still unable to reduce the mycobacterial load within the tissues, apparently because of their inherent resistance to inactivation by immunologically activated macr ... | 1984 | 6490088 |
| cutaneous mycobacterium kansasii infection presenting as cellulitis. | an immunocompromised renal transplant patient developed a cellulitis-like lesion on the leg. this lesion and subsequent periarticular lesions proved to be due to mycobacterium kansasii. although cutaneous infection due to these microorganisms is rare, in selected cases it should be considered in the differential diagnosis. | 1983 | 6825464 |
| rapid increase of the incidence of lung disease due to mycobacterium kansasii in japan. | until 1977, the incidence of lung disease due to mycobacterium kansasii in japan was as low as 0.11 or fewer per 10(5) people per year. it began to increase from 1978, reaching 0.33 per 10(5) people per year in 1981. in contrast, the incidence of lung disease due to the m avium-m intracellulare complex was 1.22 to 1.69 per 10(5) people per year from 1977 to 1981. in 1977, the fraction of the disease due to m kansasii in all atypical mycobacterioses was 6.9 percent, while in 1981 it increased to ... | 1983 | 6851691 |
| mycobacterium kansasii pericarditis. | | 1984 | 6505996 |
| cutaneous lesions due to mycobacterium kansasii. | a recipient of a renal homograft had cutaneous lesions on the lower extremities that resembled pyogenic abscesses. staphylococcus aureus consistently grew from cultures and despite appropriate antibiotics, the lesions did not completely resolve. when special cultures were done, mycobacterium kansasii was discovered. in immunocompromised patients with infectious cutaneous lesions, skin biopsy using appropriate stains and cultures should be considered early in the course of the illness. | 1980 | 6986854 |
| mycolic acid patterns of some species of mycobacterium. | representative strains of some species of mycobacterium were degraded by both acid and alkaline methanolysis. two-dimensional thin-layer chromatography was used to determine the patterns of mycolic acids and other long-chain components in these methanolysates. patterns composed of alpha-, methoxy- and ketomycolates were found in mycobacterium asiaticum, mycobacterium bovis, mycobacterium gastri, mycobacterium gordonae, mycobacterium kansasii, mycobacterium marinum and mycobacterium tuberculosis; ... | 1984 | 6517656 |
| pulmonary infection with m. kansasii in a renal transplant patient. | a 24-year-old man developed a severe pleuropulmonary infection with mycobacterium kansasii 18 months after receiving a kidney transplant from his mother. intestinal malabsorption with severe diarrhea and a skin abscess disappeared and his pneumonia was cured when rifampin was administered. this suggested that generalized dissemination with m. kansasii may have been present. | 1980 | 7001262 |
| specific skin-reactive protein from culture filtrate of mycobacterium bovis bcg. | a highly purified protein, named mpb70, was isolated from the culture filtrate of mycobacterium bovis bcg. this protein accounted for more than 10% of the proteins secreted into the culture medium. mpb70 was purified by precipitation with ammonium sulfate, followed by treatment with diethylaminoethyl ion exchanger, with or without 3 m urea, and by gel filtration. the final mpb70 preparation was homogenous as judged by several analyses. the molecular weight was estimated to be 18,000 by electroph ... | 1981 | 7014457 |
| improved technique for isolation of mycobacterium kansasii from water. | a new concentration procedure, together with a new isolation medium, resulted in a 10- to 100-fold increase in the possibility of identifying mycobacterium kansasii from water samples in comparison to a previously used procedure. in a survey which included both potable and natural water samples from many sites within the state of texas, nine isolations of high-catalase strains of m. kansasii were obtained from 232 water samples tested. acid-fast smear results were compared with mycobacterial iso ... | 1981 | 7016916 |
| experimental infection with mycobacterium kansasii in athymic nude mice. | subcutaneous infection with mycobacterium kansasii did not cause mortality in athymic nu/nu and control nu/+ mice. it had a stimulatory activity comparable to obligatory mycobacterial pathogens: thymus-dependent lymphatic tissues areas were populated during the infection by lymphocytes also in nu/nu mice in which a low degree of migration inhibition factor production could be seen. in both models of chief site of mycobacterial trapping and phagocytosis was the hyperplastic interdigitating cell m ... | 1984 | 6540715 |
| association of prior nocardiosis and subsequent occurrence of nontuberculous mycobacteriosis in a defined, immunosuppressed population. | a retrospective epidemiologic and risk factor analysis demonstrated an association of prior nocardiosis to the subsequent development of nontuberculous mycobacteriosis in five cardiac allograft recipients. strong statistical support for this association was derived from five separate analytical approaches, including comparisons with time-matched cohorts and by multivariate regression analysis. each of the five patients in the study had had uncomplicated pulmonary nocardiosis and had been treated ... | 1982 | 7050254 |
| diagnostic criteria for pulmonary disease caused by mycobacterium kansasii and mycobacterium intracellulare. | a study of 271 patients infected with mycobacterium kansasii and 226 patients with mycobacterium avium-intracellulare complex has led to the proposal of new diagnostic criteria. these criteria, based on the presence or absence of cavitation and on the duration of sputum positivity after initiation of therapy, are proposed to more accurately distinguish colonizations from active invasion of tissue than the current diagnostic criteria. | 1982 | 7073107 |
| granulomatous infections complicating hairy cell leukemia. | of 14 patients with hairy cell leukemia (hcl), four developed opportunistic granulomatous infections: blastomycosis, coccidioidomycosis and two mycobacterium kansasii. the former two pathogens have not been reported with hcl, while m. kansasii infections appear to be common. while most reviews stress susceptibility to pyogenic bacteria and the predisposing role of iatrogenic factors, three of our patients were infected prior to any therapy. thus, disease-related factors predispose to these granu ... | 1982 | 7074589 |
| in vitro activity of trimethoprim and sulfamethoxazole against the nontuberculous mycobacteria. | trimethoprim (tmp) and sulfamethoxazole (smz) were studied alone and in combination (tmp-smz) against 141 nontuberculous mycobacteria; an agar dilution method was used. all strains of mycobacterium kansasii (8), mycobacterium marinum (16), and mycobacterium scrofulaceum (3); 97% (63 of 65) of strains of mycobacterium fortuitum; and 27% (3 of 11) of strains of mycobacterium avium-intracellulare were inhibited by less than or equal to 32 micrograms of smz/ml. in contrast, all 38 isolates of mycoba ... | 1982 | 7111959 |
| soft tissue infections due to mycobacterium kansasii. | | 1980 | 6102977 |
| n-acylkansosamine. a novel n-acylamino sugar from the trehalose-containing lipooligosaccharide antigens of mycobacterium kansasii. | a novel n-acylamino sugar was isolated from the antigenic trehalose-containing lipooligosaccharides iv-vii of mycobacterium kansasii. the native reducing sugar, its o-acetyl derivative, the methylglycoside, the o-acetylated alditol, and the de-n-acylated n-, o-acetylated alditol were all examined by high resolution 1h nmr, 13c nmr, direct probe and gas-liquid chromatography-mass spectrometry in both the chemical ionization and electron impact modes, and by high resolution mass spectrometry. the ... | 1984 | 6547719 |
| [tumor-like x-ray shadow produced by mycobacterium kansasii infection]. | | 1982 | 7131993 |
| pulmonary cavitations in mycobacterium kansasii: distinctions from m. tuberculosis. | the initial radiographs of 263 patients with pulmonary mycobacterium kansasii infections were reviewed. forty-nine untreated patients with active disease had unilateral lesions containing cavities less than 2 cm in diameter. the radiographs of these 49 patients were studied further and were found to have four distinct patterns: pattern 1, a circumscribed opacity containing a single cavity (39%); pattern 2, a circumscribed opacity with multiple lucencies (39%); pattern 3, multiple round or oval o ... | 1984 | 6610306 |
| [a case report on disseminated mycobacterium kansasii infection]. | | 1982 | 7169715 |
| [a study on experimental mycobacterioses provoked by atypical mycobacteria. 4. single antituberculous drug chemotherapy against conventional mice infected intravenously with mycobacterium kansasii]. | | 1982 | 7176298 |
| [a study on experimental mycobacterioses provoked by atypical mycobacteria. 5. combined antituberculous chemotherapy against conventional mice infected intravenously with mycobacterium kansasii]. | | 1982 | 7176299 |
| two cases of mycobacterium kansasii infection occurring in the same household. | | 1982 | 7179479 |
| infections in hairy cell leukemia (leukemic reticuloendotheliosis). | of 22 patients with hairy cell leukemia, 18 developed life-threatening infections. susceptibility to infection appeared to be increased nonspecifically, in that a wide range of infecting organisms were noted. pseudomonas aeruginosa was the organism isolated most frequently. four patients had disseminated mycobacterium kansasii, and one had bacillus calmette-guerin lymphadenitis. two patients developed serious fungal infections (candida albicans in one and allescheria boydii in the other). one pa ... | 1981 | 7226028 |
| [atypical mycobacterium infection in japan (the 1981 report of the mycobacteriosis research group of the national chest hospitals). increases of the incidences of mycobacterium kansasii infection and variability of the infective organisms (incidences of mycobacterium nonchromogenicum infection)]. | | 1983 | 6620789 |
| [a case of pulmonary disease due to mycobacterium kansasii (author's transl)]. | | 1981 | 7230591 |
| disseminated mycobacterium kansasii presenting with skin lesions in a patient with chronic lymphocytic leukemia. | a patient with chronic lymphocytic leukemia developed skin lesions from which mycobacterium kansasii was cultured. the organism was also recovered from sputum cultures. twenty-three additional cases of disseminated m kansasii infection are reviewed. this disease tends to occur in patients with altered immune response, and atypical histology of tissue specimens may delay diagnosis and treatment. | 1981 | 7242466 |
| isolation of mycobacterium kansasii from lymph nodes of cattle in the united states. | the isolation of 6 strains of mycobacterium kansasii from bovine lymph nodes is reported. occasional isolations of this organism from cattle lymph node lesions provides further evidence of its pathogenicity in domestic animals. the isolates were similar as determined by biochemical and serologic examinations. histopathologic changes induced by this organism relative to those by m bovis and factors regarding source of infection are discussed. | 1983 | 6638644 |
| short-course chemotherapy for pulmonary disease caused by mycobacterium kansasii. | forty patients with pulmonary disease caused by mycobacterium kansasii were treated initially with rifampin, isoniazid, and ethambutol daily for 12 months, and with streptomycin twice weekly for the first 3 months. postchemotherapy follow-up examinations have ranged from 6 to 68 months, with an average of 31 months. one of the 40 patients (2.5%) relapsed 6 months after completion of chemotherapy. in vitro susceptibility of the mycobacteria to the drugs used, extent of disease, and/or the coexist ... | 1983 | 6650978 |
| an improved reagent for mycobacterial nitrate reductase tests. | a new crystalline reagent for nitrate reductase tests was compared with standard liquid reagents on 437 strains of mycobacteria. the results for isolates of mycobacterium avium complex, mycobacterium kansasii, mycobacterium gordonae, mycobacterium scrofulaceum, mycobacterium fortuitum, and mycobacterium chelonei agreed 100% with the expected results. of the 177 mycobacterium tuberculosis isolates, 4 were negative by the conventional method. two of these four isolates were positive with the new r ... | 1983 | 6685134 |
| synovial infection with mycobacterium kansasii. | atypical mycobacteria have been recognised as saprophytic organisms for many years, but it was only with the development of better microbiological culture techniques that they became recognised as potentially pathogenic to man. infections of tendon sheaths and joints by these organisms may present diagnostic problems, and we report here 3 cases in which mycobacterium kansasii was responsible for disease at the hand and wrist. | 1984 | 6696525 |
| serological specificity of phenolic glycolipid i from mycobacterium leprae and use in serodiagnosis of leprosy. | the serological activities of the specific phenolic glycolipid i from mycobacterium leprae, its dissected parts, and related glycolipids from other mycobacteria were examined by enzyme-linked immunosorbent assay against hyperimmune anti-m. leprae rabbit antiserum and sera from patients with leprosy and other mycobacterial diseases. high anti-phenolic glycolipid i immunoglobulin m antibodies were found in 23 of 24 (96%) of lepromatous leprosy patients on short term chemotherapy and in 8 of 13 tub ... | 1983 | 6193065 |
| mycobacterium kansasii infections in the netherlands: a brief summary. | | 1981 | 7339798 |
| isolation, characterization, and specificity of a glycoprotein antigen from mycobacterium kansasii. | we have isolated in highly purified form and characterized a glycoprotein antigen from culture filtrates of mycobacterium kansasii. immunoelectrophoretic studies demonstrated that this antigen is present only in m. kansasii among 14 species of mycobacteria studied. it is a potent tuberculin skin test antigen, but skin test reactions to it in sensitized guinea pigs display only limited specificity. enzyme-linked immunoabsorbent antibody assays of serum samples from patients suffering from disease ... | 1983 | 6196999 |
| adoptive transfer of acquired resistance to mycobacterium kansasii by t cells harvested from chronically-infected mice. | growth of mycobacterium kansasii in intravenously infected mice ceases when the spleen cells express an enhanced non-specific resistance to a secondary challenge. mice inoculated with 10(6) cfu m. kanasii 1203 develop a population of splenic t cells which are able to transfer protection passively to sublethally-irradiated syngeneic recipients when challenged with m. kansasii. although the t-cell activated macrophages were unable to eliminate the mycobacteria from the spleen, they were able to pr ... | 1984 | 6334021 |
| pulmonary infection caused by atypical mycobacteria: a report of 24 cases in thailand. | from 1969 to 1978, 24 patients were suspected of having pulmonary disease caused by atypical mycobacteria. seven were infected with mycobacterium avium-intracellulare, six with mycobacterium avium, six with mycobacterium scrofulaceum, two with mycobacterium fortuitum, and one with mycobacterium gordonae. one patient had a strain of scotochromogens antigenically related to mycobacterium simiae. mycobacterium kansasii was found in only one patient. retrospective analysis revealed that 20 of the pa ... | 1981 | 7339809 |
| in vitro and in vivo susceptibility of atypical mycobacteria to various drugs. | in vitro sensitivities to various drugs of a total of 106 strains of atypical mycobacteria were studied in modified dubos tween albumin liquid medium. eight triple-drug combinations of antituberculous drugs were also evaluated in vitro for their potentiated activities. minimal to moderate potentiation was demonstrated in the majority of the combination. from the results, the triple-drug combination--including rifampin, one of three aminoglycosides (streptomycin, kanamycin, viomycin), and either ... | 1981 | 7339820 |
| recent experience in the epidemiology of disease caused by atypical mycobacteria. | to obtain information on the epidemiology of mycobacteriosis, water and air samples collected along the east coast of the united states were examined for mycobacteria. mycobacterium avium-intracellulare-scrofulaceum (mais) were isolated from 25% of the water, samples, mostly those from south carolina, georgia, and the gulf states. mycobacterium kansasii and mycobacterium marinum were not found, probably because of the detrimental effects of the naoh used to decontaminate the samples. mais strain ... | 1981 | 7339831 |
| epidemiologic studies of lung disease due to mycobacteria other than mycobacterium tuberculosis in japan. | the incidence of lung disease due to mycobacteria other than mycobacterium tuberculosis (atypical mycobacteria) in japan was estimated to be 0.9--1.9 per 10(5) population per year in 1971--1979. although the incidence of lung tuberculosis is steadily decreasing, the incidence of lung disease due to atypical mycobacteria has remained at almost the same level. the number of patients newly infected per year in recent years was calculated to be approximately 2,000. the ratio of the number of patient ... | 1981 | 7339832 |
| phage typing of mycobacterium kansasii. | an improved phage typing scheme of m. kansasii is presented. ultrasonic treatment of the bacterial suspensions was successfully used in order to obtain homogeneous bacterial growth and to improve the reproducibility of the typing. by means of 9 phages 14 lysis patterns (phage types) could be distinguished. the phage typing was applied to 450 strains of dutch, british and czechoslovakian origin. the epidemiological relationships between environmental and clinical isolates of m. kansasii among the ... | 1980 | 7368319 |
| the occurrence of mycobacterium kansasii in tapwater. | m. kansasii was demonstrated in tapwater in the city of rotterdam. out of 78 taps examined 6 times during 1 year, 49 per cent yielded m. kansasii at least once. examination of over 100 samples of the mains water supply yielded only 1 positive sample. the data suggest colonization of the water systems within buildings by m. kansasii in particular places. phage typing demonstrated human and tapwater isolates to belong to the same phage types. | 1980 | 7368320 |
| polyarthritis due to mycobacterium kansasii in a patient with rheumatoid arthritis. | a case of destructive polyarthritis due to infection by mycobacterium kansasii is described in a 68-year-old patient with long-standing rheumatoid arthritis (ra) receiving prednisone and azathioprine therapy. superimposed infection was suggested by positive ziehl-neelsen stains of synovial fluid from the patient's right shoulder and wrists, with confirmation on culture. histological examination of synovium revealed abundant noncaseating granulomata within subsynovial cellular infiltrates. treatm ... | 1980 | 7377866 |
| high-catalase strains of mycobacterium kansasii isolated from water in texas. | isolation techniques with membrane-filtered potable water samples resulted in the isolation of potentially pathogenic high-catalase strains of mycobacterium kansasii from 8 of 19 representative outlets in a small central texas town. mycobacterium gordonae was isolated from all samples, and mycobacterium fortuitum was isolated from two samples. data on chlorine levels are presented along with a possible explanation for the unusually high numbers of mycobacteria in these potable water samples. fin ... | 1980 | 7381016 |
| mycobacterial infections in marrow transplant patients. | bone marrow transplant recipients undergo ablation of host immune defenses with total-body irradiation or high dose chemotherapy, or both. over a 5.6-year period, mycobacterial infections were observed in 7 of 682 patients with leukemia who received marrow grafts. four patients had pulmonary and three extrapulmonary infection. granulomas were observed in the lungs of three patients, in the liver of one patient, and in the skin of one patient. cultures revealed mycobacterium tuberculosis in two p ... | 1983 | 6356515 |
| generation and characterization of monoclonal antibodies to the phenolic glycolipid of mycobacterium leprae. | nine cloned cell lines producing antibodies to the unique phenolic glycolipid of mycobacterium leprae have been established as a result of fusions with spleens from mice immunized with the glycolipid complexed with methylated bovine serum albumin. one of the antibodies was relatively nonspecific, binding to a related glycolipid from mycobacterium kansasii, but the remaining antibodies were specific for the m. leprae lipid. some of the antibodies required the intact (trisaccharide) carbohydrate p ... | 1984 | 6360894 |
| controlled trial of rifampicin and ethambutol in crohn's disease. | we pursued the possibility that mycobacterium kansasii might be an aetiological agent in crohn's disease by carrying out a trial of treatment with antimycobacterial drugs. twenty seven patients with crohn's disease took part in a two year randomised double blind, crossover, controlled trial of rifampicin plus ethambutol against placebo. fourteen patients completed the trial; four required an operation; five were withdrawn as poor compliers, and four because of adverse effects. there was no signi ... | 1984 | 6363219 |
| trehalose-containing lipooligosaccharides. a new class of species-specific antigens from mycobacterium. | mycobacterium kansasii is characterized by the presence of seven species-specific neutral lipooligosaccharide antigens. all react with hyperimmune anti-m. kansasii serum in enzyme-linked immunosorbent assays, and the more glycosylated members also react by gel diffusion. both the native glycolipids and their inherent oligosaccharides were purified and the major features of their unique structures determined by acetolysis, partial acid cleavage, 1h-nmr and 13c-nmr, and chemical ionization and ele ... | 1983 | 6411715 |
| resistance of various strains of mycobacteria to killing by activated macrophages in vivo. | a variety of experimental infections with pathogenic mycobacteria are associated with the development of persistent disease, in which little or no changes in the numbers of the infectious organism can be detected. this report describes a simple experimental model designed to test the hypothesis that this persistence may reflect in part the ability of these organisms to resist the enhanced bacteriostatic and bactericidal properties acquired by host macrophages as a result of these mycobacterial i ... | 1983 | 6411817 |
| comparison of the e test and a proportion dilution method for susceptibility testing of mycobacterium kansasii. | the newly developed e test was compared with a conventional proportion dilution method for determining the sensitivity of mycobacterium kansasii to amikacin, streptomycin, fusidic acid, rifampicin, clarithromycin, ciprofloxacin, ofloxacin, and fleroxacin. there was no more than one strain with different rating, except for ciprofloxacin. in this case, the breakpoint concentration had an unfavourable position at the top of the strip, and susceptible isolates in the dilution test were defined resis ... | 1995 | 7555204 |
| lymphadenopathy complicating hairy cell leukaemia. a case of disseminated mycobacterium kansasii infection. | a patient with hairy cell leukaemia is described who developed progressive lymphadenopathy, which proved to be due to mycobacterium kansasii infection. clinicians should be alert to this rare but well-described complication of hairy cell leukaemia. early lymph node biopsy is recommended in patients developing otherwise unexplained fever and lymph node enlargement. | 1983 | 6414229 |
| identification and preliminary purification of a protein antigen apparently specific to mycobacterium kansasii. | a highly anodal protein antigen of molecular weight approximately 10,000 daltons has been identified in culture filtrates of mycobacterium kansasii and not in culture filtrates of 9 other mycobacterial species. using immunoabsorbent affinity chromatography, this antigen has been purified and used to skin test guinea pigs sensitized with mycobacterium kansasii and mycobacterium tuberculosis. in these animals it was found to be tuberculin active and to have partial species specificity. | 1980 | 6774641 |
| bacteriology of sinusitis in human immunodeficiency virus-positive patients: implications for management. | the bacteriology of sinusitis in human immunodeficiency virus (hiv)-infected patients has been only sporadically reported. in this study, we report the results of cultures taken from 12 hiv patients with refractory chronic sinusitis who underwent surgery. nine of the 12 patients had positive cultures with 16 isolates and 5 patients having multiple isolates. five of the 12 patients grew out atypical or opportunistic infections not responsive to standard medical therapy, including 3 patients with ... | 1995 | 7564835 |
| cellular immunity in natural and experimental infections caused by mycobacterium tuberculosis and mycobacterium kansasii. | in rabbits sensitized with m. tuberculosis and m. kansasii the of macrophage migration inhibition from the spleen due to antigens of both types of mycobacteria was evaluated. in parallel experiments the release of mif the indirect migration inhibition was evaluated, using antigens added to lymphocyte suspensions from popliteal nodes of sensitized animals. as an indicator system spleen fragments of intact rabbits were used. in patients excreting m. tuberculosis and m. kansasii (groups of 31 subje ... | 1980 | 6774866 |
| nontuberculous mycobacterial trends at the veterans administration medical center in oklahoma city. | laboratory culture results, dating back to 1960, were reviewed at the veterans administration medical center in oklahoma city. nontuberculous mycobacterial incidence increased substantially during the 21-year period as tuberculosis incidence decreased. nontuberculous mycobacteria were found to represent 13.7% of all mycobacterial isolates, with mycobacterium kansasii and m intracellulare-avium complex the predominant species. when the dates of first positive cultures were evaluated, a significan ... | 1983 | 6823573 |
| a highly immunogenic putative mycobacterium kansasii lipoprotein. | the resurgence of tuberculosis, the emergence of multiple drug resistant tuberculosis, and the increasing prevalence of mycobacterial disease in aids patients have increased the importance of defining new mycobacterial antigens that can be utilized in the development of improved diagnostic reagents and more effective vaccines. in this report, a highly immunogenic mycobacterium kansasii protein (mk35) and the gene encoding this antigen were characterized. mk35 gene probes reacted with genomic dna ... | 1995 | 7582031 |
| comparative in-vitro activities of the new quinolone, bay y 3118, and ciprofloxacin, sparfloxacin, tosufloxacin, ci-960 and ci-990. | the in-vitro activity of the new quinolone, bay y 3118, was compared with that of ciprofloxacin, tosufloxacin, sparfloxacin, ci-960 and ci-990 against 1640 isolates belonging to 117 bacterial species. against members of the enterobacteriaceae, bay y 3118 was as active as ci-960 and ci-990, up to four-fold more active than ciprofloxacin and tosufloxacin and up to 16-fold more active than sparfloxacin. the majority of enterobacteriaceae which were resistant to ciprofloxacin (mics > or = 2 mg/l) we ... | 1993 | 7605398 |
| demonstration of mycobacterium kansasii species heterogeneity by the amplification of the 16s-23s spacer region. | amplification of the region separating the genes coding for the two rrna species 16s and 23s was performed with 56 strains of several mycobacterial species, including 21 clinical isolates of mycobacterium kansasii and the m. kansasii type strain atcc 12478. on the basis of pcr product profiles, the previously suggested heterogeneity of m. kansasii species was confirmed. three subgroups were identified; members of the first subgroup showed the same pcr profile as the reference strain. different p ... | 1995 | 7629856 |
| cloning and sequencing of the gene for alpha antigen from mycobacterium avium and mapping of b-cell epitopes. | the complete nucleotide sequence of alpha antigen secreted from mycobacterium avium (a-alpha) was determined. the gene encodes 330 amino acids, including 40 amino acids for the signal peptide, followed by 290 amino acids for the mature protein with a molecular mass of 30,811 da. this is the first sequence of a-alpha. comparisons between a-alpha and alpha antigens of mycobacterium leprae, mycobacterium bovis bcg, and mycobacterium kansasii showed highly homologous regions which suggested a conser ... | 1993 | 7681039 |
| pulmonary infection with mycobacterium kansasii in wales, 1970-9: review of treatment and response. | thirty-five patients (88% male) with pulmonary infection caused by mycobacterium kansasii have been reviewed. sixty-six per cent had pre-existing lung disease, chronic bronchitis and emphysema accounting for half of the disorders. unilateral lesions were present in 69% of patients whose chest radiographs were reviewed and 90% had cavitating disease. the development of unilateral or bilateral disease appeared to be independent of any delay in starting treatment. five patients died while receiving ... | 1983 | 6867979 |
| the aetiology of acute cervical adenitis in children: serological and bacteriological studies. | acute cervical adenitis was investigated in 26 children over a 33-month period. lymph nodes were aspirated and cultured to yield staphylococcus aureus or group-a streptococci or both from 22 (84.6%) of the aspriates. mycobacterium kansasii was isolated from one child. by combined culture and serial serological tests (antistreptolysin-o, anti-dnaase b, and anti-nadase), 50% of the cases were found to be associated with streptococcal infection. in a few children, s. aureus was the only organism re ... | 1980 | 6987407 |
| a novel phenolic glycolipid from mycobacterium leprae possibly involved in immunogenicity and pathogenicity. | a phenolic glycolipid was obtained in high amounts (2% of dry weight) from mycobacterium leprae isolated from infected armadillo liver. infrared and nuclear magnetic resonance spectroscopy showed that it is closely related to "mycoside a" from mycobacterium kansasii and is therefore a glycosylphenolic phthiocerol diester. the crucial difference between the two products is in the composition of the attached trisaccharide. gas-liquid chromatography-mass spectroscopy showed that the product from m. ... | 1981 | 7024248 |
| purification and characterization of a low-molecular-mass t-cell antigen secreted by mycobacterium tuberculosis. | a novel immunogenic antigen, the 6-kda early secretory antigenic target (esat-6), from short-term culture filtrates of mycobacterium tuberculosis was purified by hydrophobic interaction chromatography and anion-exchange chromatography by use of fast protein liquid chromatography. the antigen focused at two different pis of 4.0 and 4.5 during isoelectric focusing, and each of these components separated into three spots ranging from 4 to 6 kda during two-dimensional sodium dodecyl sulfate-polyacry ... | 1995 | 7729876 |
| treatment of pulmonary disease caused by mycobacterium kansasii: results of 18 vs 12 months' chemotherapy. | chest clinic, sant pau hospital, barcelona, spain. | 1995 | 7780090 |
| [indications for an increase in lung disease caused by mycobacterium kansasii in the former limburg mining area?]. | to establish the occurrence of lung disease caused by mycobacterium kansasii in order to determine whether the incidence has increased since 1991. | 1995 | 7791934 |
| cutaneous mycobacterium kansasii infection: case report and review. | a case of cutaneous mycobacterium kansasii infection is reported, and 28 similar cases are reviewed. cutaneous infection may resemble sporotrichosis and is often associated with systemic illness, immunosuppression, skin pathology, or contact with contaminated water. immunosuppressed patients with m. kansasii infection may present with atypical clinical features (such as cellulitis and seroma) and atypical histology (absence of granulomas), which may delay diagnosis and effective treatment. the i ... | 1995 | 7795078 |
| lymphadenitis due to mycobacterium kansasii in an adult. | | 1982 | 7112440 |
| [studies on the lung disease due to atypical mycobacteria in japan (report of the year 1980 of the mycobacteriosis research group of the national chest hospitals. changes of epidemiologic status of mycobacterium kansasii disease, from endemicity to epidemicity]. | | 1982 | 7120725 |
| early response of lymphatic system to experimental infection with mycobacterium kansasii and mycobacterium scrofulaceum. | weight, cellularity and metabolic activity (nucleolar test) of draining and contralateral popliteal lymph nodes were studied in groups of guinea pigs infected intratarsally in right hind limb with mycobacterium kansasii (2.4 x 10(6) viable units) and mycobacterium scrofulaceum (3.4 x 10(6) viable units) species and examined 1, 3, 7 and 14 days after inoculation. time-related differences and inter-group differences in cellularity and per cent of active lymphocytes were statistically analyzed by p ... | 1982 | 7142687 |
| endemic occurrence of mycobacterium kansasii in water-supply systems. | of a total number of 1079 drinking water and colliery service water samples examined in an area of the north-moravian region czechoslovakia, characterized by endemic occurrence of m. kansasii infections, 233 [21.6%] samples were found to be contaminated by mycobacteria, of these 20 [1.9%] by m. kansasii. of additionally examined 510 water samples from the municipal water-supply network, which were collected in hospital laboratories and clinical departments as well as in the households of patient ... | 1981 | 7229352 |
| [atypical mycobacterial infections]. | infrequent and forgotten before the advent of the acquired immune deficiency syndrome (aids), non-tuberculous mycobacterial infections are now often encountered, predominately in patients positive for the human immune deficiency virus (hiv). in non-aids patients, mycobacterium kansasii, m. avium and m. xenopi are the most common causal agents of pulmonary mycobacterial infections. nodes and skin diseases are less frequent. m. kansasii infections are treated for 12 months with a standard combinat ... | 1994 | 7824469 |
| in-vitro activity of quinolones and macrolides against mycobacteria. | the activities of eight quinolones (ciprofloxacin, clinafloxacin, levofloxacin, ofloxacin, a-80556, sparfloxacin, temafloxacin and tosufloxacin) and three macrolides (azithromycin, clarithromycin and erythromycin) against 98 clinical isolates of mycobacterium tuberculosis and 120 isolates of five different atypical mycobacterial species including 20 mycobacterium kansasii, 25 mycobacterium scrofulaceum, 25 mycobacterium avium/intracellulare, 25 mycobacterium chelonae and 25 mycobacterium fortuit ... | 1994 | 7829409 |
| release of tnf alpha and il6 from human monocytes infected with mycobacterium kansasii: a comparison to mycobacterium avium. | tumor necrosis factor alpha (tnf alpha) and interleukin 6 (il6) are cytokines with a varied spectrum of inflammatory and immunological activities, for example modulation of acute phase proteins, fever and stimulation of b-lymphocytes. mycobacterium avium has been shown to stimulate the release of tnf alpha and il6 from cultured human monocytes and macrophages into the cell supernatant. cultured human monocytes were infected with mycobacterium kansasii and m. avium. the concentrations of tnf alph ... | 1994 | 7843810 |
| relationship between photochromogenicity and test temperature in mycobacteria. | although it has been recommended that photochromogenicity of mycobacteria should be tested after incubation at 25 to 30 degrees c for 2 weeks (wayne et al., int. j. syst. bacteriol. 24:412-419, 1974), our results indicate that photochromogenicity should be determined at 37 degrees c in the dark and under continuous exposure to light for 2 weeks. the test at 37 degrees c gives more stable results for mycobacterium kansasii, mycobacterium marinum and mycobacterium szulgai. | 1981 | 7276150 |
| mycobacterium kansasii infection in an endemic area of czechoslovakia. | over the period 1968-1979, mycobacterium kansasii was isolated from a total of 297 persons residing in the district of karviná, north-moravian region, czechoslovakia. repeated m. kansasii isolations were recorded in 153 patients with clinical symptomatology of chronic respiratory disorders, single isolations in another 144 persons (121 isolations from sputum and/or laryngeal swabs, 22 from urine, and one from the aspirate of a lymph node with tuberculoid granuloma). the incidence of infection wi ... | 1980 | 7281235 |
| atypical mycobacterial infections: a clinical study of 92 patients. | between july 1970 and december 1979, 92 patients with atypical mycobacterial infections of the lung were hospitalized 110 times at blue ridge hospital (charlottesville, va). these patients comprised less than 3% of all patients hospitalized for active mycobacterial disease. sixteen had mycobacterium kansasii or group i disease, three had group ii disease (two m scrofulaceum, one m szulgai), 70 had group iii disease (68 m avium-intracellulare, two m xenopi), and three had m fortuitum or group iv ... | 1981 | 7302627 |
| use of gen-probe accuprobes to identify mycobacterium avium complex, mycobacterium tuberculosis complex, mycobacterium kansasii, and mycobacterium gordonae directly from bactec tb broth cultures. | to evaluate the utility of gen-probe accuprobes for the identification of mycobacteria directly from bactec tb 12b vials containing acid-fast bacilli, culture results for 11,375 clinical specimens other than blood received from 1 january 1992 to 30 september 1993 were reviewed retrospectively. during this period, a total of 359 of 11,375 bactec vials were positive for acid-fast bacilli and were evaluated for mycobacteria with one or more probes: 224 were probed for mycobacterium tuberculosis com ... | 1994 | 7883888 |
| tuberculin peptide from culture filtrate of mycobacterium tuberculosis. | a highly purified tuberculin peptide, named tph71u, was isolated from the heated culture filtrate of mycobacterium tuberculosis strain h37rv. this peptide was prepared by precipitation with ammonium sulfate and by treatment with diethylaminoethyl-sephadex, sephadex g-75, and preparative gel electrophoresis in the presence of a high concentration of urea. the presence of urea remarkably increased the sensitivity of the gel analysis and the efficiency of the preparation procedure. the isolated pep ... | 1980 | 6774637 |
| sensitivity of opportunist mycobacteria to rifampicin and ethambutol. | a total of 1237 strains of opportunist mycobacteria were tested for sensitivity to rifampicin and ethambutol. most strains of mycobacterium kansasii and all strains of m. marinum tested were sensitive to both drugs. a variable pattern was given by m. xenopi strains, but a general resistance was observed with the m. avium--intracellulare--scrofulaceum group. all strains of m. fortuitum and m. chelonei were highly resistant. scotochromogens were mostly sensitive to ethambutol, but there was variab ... | 1981 | 7303160 |
| mycobacterium kansasii empyema. | | 1981 | 7303161 |
| chemotherapy for pulmonary disease due to mycobacterium kansasii: efficacies of some individual drugs. | an evaluation of chemotherapy was made for 256 patients with pulmonary infection due to mycobacterium kansasii. studies of in vitro resistance of m. kansasii and mycobacterium tuberculosis to various drugs revealed important differences between the two species that should be considered when planning chemotherapy. partial or no in vitro resistance to 1 microgram of isoniazid/ml did not adversely affect the time required for conversion of sputum from positive to negative, whereas complete resistan ... | 1981 | 7339800 |
| treatment of pulmonary disease due to mycobacterium kansasii: recent experience with rifampin. | records of 244 patients with mycobacterium kansasii isolated from their sputum were reviewed. of the 244 patients, 82 failed to meet study criteria and were excluded. response to treatment and posttreatment follow-up was evaluated in 162 patients. overall, 135 patients (83%) achieved negative sputum cultures within six months. among 32 patients whose drug regimen included rifampin, all 32 (100%) had negative cultures at the fourth and fifth months, but two relapsed during the sixth month, with c ... | 1981 | 7339801 |
| genitourinary tract infections due to atypical mycobacteria. | a patient with chronic prostatitis caused by mycobacterium kansasii is reported, demonstrating that these organisms occasionally cause urinary tract infections. criteria useful in evaluating the clinical significance of atypical mycobacteria isolated from the urine are suggested. application of these criteria to 19 patients encountered in routine clinical practice demonstrates their usefulness. | 1980 | 7401239 |
| mycobacterium kansasii and osteoarticular lesions. | four patients with an unusual type of bone lesion are reported. the histological diagnosis in two of them was non-specific chronic inflammation and one case was diagnosed as chronic eosinophilic granuloma. on subjecting the material to culture mycobacterium kansasii (a photochromogen) were isolated. it is suggested that m. kansasii are capable of producing osteoarticular lesions with a rather vague clinical and radiological picture not typical of osteoarticular tuberculosis. | 1980 | 7446028 |
| susceptibilities of nontuberculosis mycobacterial species to amoxicillin-clavulanic acid alone and in combination with antimycobacterial agents. | neither amoxicillin nor clavulanic acid used alone was active at the highest level tested, i.e., 256.0 micrograms/ml, in vitro against 24 isolates of mycobacterium fortuitum, mycobacterium kansasii, and mycobacterium marinum. however, the mic of an amoxicillin-clavulanic acid combination of 2:1 was < or = 8.0/4.0 micrograms/ml for 50 percent of the isolates tested, with all isolates being inhibited in the range of 4.0/2.0 to 32.0/16.0 micrograms/ml, respectively. titration of amoxicillin-clavula ... | 1995 | 7492084 |
| lipooligosaccharidic antigens from mycobacterium kansasii and mycobacterium gastri. | a set of lipooligosaccharides (loss) has previously been characterized in m. gastri w471. the structure of the highly antigenic los (los-iii) was elucidated and this molecule can unambiguously distinguish m. gastri from the opportunistic pathogen m. kansasii. in the present study, the structures of three other m. gastri w471 loss were determined by one-dimensional 1h-nmr spectroscopy and gas liquid chromatography. they differ by the number of xylp units and by the structure of the distal monosac ... | 1995 | 7496145 |
| disease due to mycobacterium kansasii in the czech republic: 1984-89. | endemic area of north moravia, czech republic. | 1995 | 7548902 |
| effect of panta on growth of mycobacterium kansasii in bactec 12b medium. | mycobacterium kansasii isolates from two patients showed relatively slow growth in bactec 12b medium (12b) (becton dickinson diagnostic instrument systems, sparks, md.) compared with the more rapid growth of these isolates on solid media. this finding prompted an evaluation of the effect of panta (becton dickinson) on the growth rate of these isolates. suspensions of one isolate from each of these two patients (a and b), six additional isolates from six other patients (c through h), and one m. k ... | 1995 | 7559939 |
| pyrazinoic acid esters with broad spectrum in vitro antimycobacterial activity. | a series of substituted pyrazinoic acid esters has been prepared and examined for their in vitro activity against mycobacterium avium and mycobacterium kansasii as well as mycobacterium tuberculosis. modification of both the pyrazine nucleus and the ester functionality have been very successful in expanding the activity of pyrazinamide to include m. avium and m. kansasii, organisms normally not susceptible to pyrazinamide. several of these compounds have activities 100-1000-fold greater than tha ... | 1995 | 7562923 |
| clinical significance of nontuberculous mycobacteria isolates in a canadian tertiary care center. | to determine the epidemiology and clinical features of disease due to nontuberculous mycobacteria (ntm) in our institution, we reviewed the medical records of all patients from whom ntm isolates were recovered from 1988 to 1990 to extract selected clinical and laboratory data. on the basis of the likelihood of infection, patients were classified as having definite, probable, or unlikely ntm disease as defined by published guidelines. of 80 patients who met the inclusion criteria, 17 had definite ... | 1995 | 7578721 |