Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| osteomyelitis due to mycobacterium intracellulare. | 1981 | 7254923 | |
| [clinical effect of chemotherapy including minocycline on lung infection due to mycobacterium avium-mycobacterium intracellulare (author's transl)]. | 1981 | 7265604 | |
| the duration of the response of cattle to inoculation with atypical mycobacteria. | each of 4 strains of atypical mycobacteria was inoculated into 2 cattle and the responses of the cattle were studied over the following 52 weeks. each strain was injected subcutaneously into one animal and into a mesenteric lymph node of another. within 7 days palpable lesions were produced at the sites of subcutaneous inoculation in response to all the strains. after intervals varying from 3 to 26 weeks, lesions due to 3 of the strains were no longer palpable. the lesion produced in response to ... | 1981 | 7295237 |
| mycobacterial sensitins: where are we now? | a limited review of the results of using comparative reciprocal intradermal mycobacterial sensitin (cris) testing with guinea pigs for the classification and identification of mycobacteria is presented. the technical procedures and the materials used in cris testing are referred to only briefly. strains of mycobacteria that grow well on a synthetic nonimmunogenic medium can be identified or classified at the species level with this method. at present some 50 species of mycobacteria can be identi ... | 1981 | 7339825 |
| ["transient infection" of the lung due to mycobacterium avium-mycobacterium intracellulare complex (author's transl)]. | 1981 | 7300081 | |
| pulmonal mycobacterium intracellular infection in hairy-cell leukemia. | a case of fatal pulmonal infection with mycobacterium intracellular in a patient with hairy-cell leukemia is reported. 2 years after diagnosis and splenectomy chronic fever and progressive infiltration of the superior lobe of the left lung developed. direct microscopical examination of bronchial aspirate detected acid-fast bacilli. despite vigorous treatment with antituberculosis drugs the patient died shortly after the diagnosis of the infection. the bacteria were post mortem classified as myco ... | 1981 | 6800193 |
| specific skin-reactive protein from culture filtrate of mycobacterium bovis bcg. | a highly purified protein, named mpb70, was isolated from the culture filtrate of mycobacterium bovis bcg. this protein accounted for more than 10% of the proteins secreted into the culture medium. mpb70 was purified by precipitation with ammonium sulfate, followed by treatment with diethylaminoethyl ion exchanger, with or without 3 m urea, and by gel filtration. the final mpb70 preparation was homogenous as judged by several analyses. the molecular weight was estimated to be 18,000 by electroph ... | 1981 | 7014457 |
| structures of the typing antigens of atypical mycobacteria: a brief review of present knowledge. | the overall structures of the typing antigens from serovars in the mycobacterium avium-mycobacterium intracellulare-mycobacterium scrofulaceum complex have been elucidated. they are polar versions of the well-known c mycosides and have the general structure: [formula: see text]. the lipopeptidyl-o-(3, 4-di-o-me-rha) "core" is common to all serovars; however, the oligosaccharide moiety is different. detailed analyses of the oligosaccharides from selected serovars show that they contain four sugar ... | 1981 | 6176001 |
| [monoarthritis caused by mycobacterium intracellulare. personal observation of 2 cases and review of the literature]. | the authors report two cases of arthritis of a proximal interphalangeal articulation due to mycobacterium (m) intracellulare. in both cases, an intra-articular corticosteroid injection, given for preexisting pain, was responsible for infection. both diagnoses were based on results from cultures of biopsied tissue. histological findings in one of the cases were non-specific, whereas tuberculoid granulomas were present in the other. articular destruction had occurred in both patients at the time o ... | 1982 | 7089469 |
| diagnostic criteria for pulmonary disease caused by mycobacterium kansasii and mycobacterium intracellulare. | a study of 271 patients infected with mycobacterium kansasii and 226 patients with mycobacterium avium-intracellulare complex has led to the proposal of new diagnostic criteria. these criteria, based on the presence or absence of cavitation and on the duration of sputum positivity after initiation of therapy, are proposed to more accurately distinguish colonizations from active invasion of tissue than the current diagnostic criteria. | 1982 | 7073107 |
| the histopathology of cervical lymphadenitis caused by mycobacterium avium-mycobacterium intracellulare complex in an immunocompromised host. | 1982 | 7076196 | |
| [the importance of the infective dose, nutritional value of the feed and vitamin content for the susceptibility in pigs to mycobacterium intracellulare]. | the influence of infectious dose and nutrition on the pig susceptibility to mycobacterium intracellulare, serotype 4, 8, was studied with 48 pigs--crossbreds lw x x l--divided into four equal groups. all groups of pigs were fed ad libitum by the mixture consisting of maize, wheat, barley, soybean meal, salt lick and mkp 1 mineral feed supplement. individual groups were given different levels of meals of animal origin and biofactor supplements containing vitamins a, d2, b2, b12 and niacin. single ... | 1982 | 6817503 |
| mycobacterial cross-contamination of bronchoscopy specimens. | bronchoscopy specimens from 3 patients investigated during 1 wk at a large teaching hospital were culture positive for the same serovar of mycobacterium intracellulare. review of laboratory records and patient data suggested that only the first patient examined was a genuine excretor of mycobacteria; the isolates from the other 2 patients were false positives caused by inadequate disinfection of part of the collection apparatus between use. the investigations confirm the suitability of glutarald ... | 1982 | 6817678 |
| preseptal cellulitis caused by mycobacterium intracellulare. | a case of preseptal cellulitis caused by mycobacterium intracellulare is presented. a 56-year-old white woman developed erythema, induration, and tenderness of the lids of her right eye after chalazion removal, which did not respond to three weeks of broad spectrum antibiotics. incision and drainage with biopsy revealed granuloma, and acid-fast bacilli were seem. mycobacterium intracellulare was isolated on culture, resistant to all the antimicrobials that the patient was given. antimicrobial th ... | 1982 | 7099570 |
| mycobacterium intracellulare infection of the shoulder and spine in a patient with steroid-treated systemic lupus erythematosus. | atypical mycobacterial infections of bone are rare. a patient with systemic lupus erythematosus treated with steroids developed an m. intracellulare infection of the shoulder and spine. these infections are insidious and diagnosis is difficult. marked involvement of one joint, large effusion, or aspirated small synovial fragments suggest an atypical tuberculous joint infection. | 1982 | 7100938 |
| mycobacterium intracellulare infection in wallabies. | 1982 | 7138438 | |
| [a case of pulmonary mycobacteriosis due to mycobacterium intracellulare (author's transl)]. | an m. intracellulare, rough strain (serotype 7) has been isolated from sputum of a sixty-year old patients. this patient was a political prisoner in germany between 1942-1945 and had contracted pulmonary tuberculosis with the cavity in the upper lobe of the right lung. a strain of mycobacterium susceptible to antituberculous drugs was isolated from his sputum in 1973. since 1979, the isolation of m. intracellulare has been accompanied by clinical signs of pulmonary mycobacteriosis, i.e. persiste ... | 1982 | 7045772 |
| isolation in high frequency of rough variants of mycobacterium intracellulare lacking c-mycoside glycopeptidolipid antigens. | rough variants of serovars from the mycobacterium avium-mycobacterium intracellulare-mycobacterium scrofulaceum complex were isolated in high frequency from pellicle growth of the wild-type strains. rough morphology could be correlated with the lack of an outer cell wall sheath and its constituent c-mycoside glycopeptidolipids of both the serologically active and inactive types. | 1982 | 7061400 |
| synergistic effect of rifampin, streptomycin, ethionamide, and ethambutol on mycobacterium intracellulare. | a method of quantitative estimation to determine the interaction of antituberculosis drugs is suggested. the design of experiments, performed on 7h11 agar plates, is adjusted to the following statistical treatment by combined use of probit analysis and isobologram methods. by plotting the values reflecting the inhibition of 75% of the bacterial population (ed75) with their confidence limits on the isobologram, it was found that the clearest results proving synergism between the drugs could be ob ... | 1982 | 7065508 |
| nontuberculous mycobacterial infection attributable to mycobacterium intracellulare serotype 10 in two rhesus monkeys. | infection with mycobacterium intracellulare serotype 10 was diagnosed in 2 rhesus monkeys (macaca mulatta) in a closed colony of 90 animals. the clinicopathologic presentation in 1 animal with advanced disease was characterized by a precipitous weight loss, therapeutically unresponsive diarrhea, anemia, weakness, prostration, refractory tuberculin tests (using mammalian old tuberculin and m bovis purified protein derivative tuberculin), and disseminated granulomas in the lungs, spleen, liver, ki ... | 1982 | 7174460 |
| pulmonary tumorlets in cases of "tuberculoma" of the lung with malignant cells in brush biopsy. | two cases of pulmonary nodules associated with mycobacterium intracellulare infection were initially interpreted as carcinomas of the lung after brush cytology specimens were reported to contain malignant epithelial cells. in both instances, the cells observed in the cytology specimens exhibited marked cytologic atypia. these cells were identical to those present in tumorlets adjacent to the granulomatous lesion. tumorlets may thus represent a source of false-positive cytologic findings or const ... | 1982 | 6957103 |
| relationship between serotype and certain biological and biochemical characteristics of strains of the mycobacterium avium and mycobacterium intracellulare complex. | some relationships among schaefer's serotypes and biological and biochemical characteristics were observed in strains of the mycobacterium avium-mycobacterium intracellulare complex. strains belonging to serotypes 2 and 16 lacked the capacity to utilize n- and iso-butanols as the sole source of carbon in the presence of ammoniacal nitrogen. however, strains of serotype 2 grew at 45 c and lacked arylsulfatase activity (after 14 days), whereas strains of serotype 16 failed to grow at 45 c and show ... | 1982 | 7162433 |
| disseminated tuberculosis caused by mycobacterium intracellulare. | 1982 | 7140414 | |
| dual intradermal testing of barbadian children with tuberculin and battey bacillus antigen. | this article reports on a study comparing 2 different tuberculin tests for effective diagnosis of tuberculosis. 908 barbadian children, ages 4-8 years were tested simultaneously by intradermal injection of 0.05 g standard tuberculin (ppd--s) and an extract of mycobacterium intracellulare (battey bacillus)(ppd--b). of the total number of children tested, 21.8% reacted to both antigens. the reaction to ppd--s was significant in 2.6% and to ppd--b in 13.4%. in 5.9% of the children who reacted t ... | 1982 | 7157791 |
| uric acid utilization by mycobacterium intracellulare and mycobacterium scrofulaceum isolates. | forty-nine human and environmental isolates of mycobacterium intracellulare and mycobacterium scrofulaceum were tested for their ability to grow on uric acid and a number of its degradation products. nearly all (88 to 90%) strains used uric acid or allantoin as a sole nitrogen source; fewer (47 to 69%) used allantoate, urea, or possibly ureidoglycollate. enzymatic activities of one representative isolate demonstrated the existence of a uric acid degradation pathway resembling that in other aerob ... | 1983 | 6863220 |
| [a trial of intratracheal infection with mycobacterium intracellulare to conventional mice]. | 1983 | 6413746 | |
| postphagocytic detection of glycopeptidolipids associated with the superficial l1 layer of mycobacterium intracellulare. | the superficial l1 layer of mycobacterium intracellulare serovar 20 was detected by immunocytochemical procedures based on c-mycoside glycopeptidolipid (gpl) antigens. specific immune serum was produced by injecting a gpl-methylated bovine serum albumin complex into rabbits with freund incomplete adjuvant. the resulting antibodies were used to label serovar 20 with goat anti-rabbit immunoglobulin g (igg) conjugated with either fluorescein or ferritin. the labeled gpl antigens were then detected ... | 1983 | 6350184 |
| epidemiology of infection by nontuberculous mycobacteria. iv. preferential aerosolization of mycobacterium intracellulare from natural waters. | we report here the first laboratory studies simulating the conditions for natural aerosolization of mycobacterium intracellulare and m. scrofulaceum and estimate the yields for this pathway of transfer of pathogenic mycobacteria from water to air; m. intracellulare and m. scrofulaceum were both concentrated in droplets ejected from cell suspensions of densities comparable to those found in natural freshwaters (100 to 2,000 colony-forming units per ml). the enrichment factor (defined as the conce ... | 1983 | 6354024 |
| an acute infection model for mycobacterium intracellulare disease using beige mice: preliminary results. | the development of an acute infection model of mycobacterium intracellulare disease in beige mice (c57b1/6j-bgj/bgj) was investigated. intravenous injection of 1 x 10(7) viable colony-forming units of m. intracellulare strain 571-8 produced a 1,000-fold increase in the number of mycobacteria recovered from the lungs and spleens after 28 days of infection. more importantly, 40% of the beige mice died from this infection, as was determined from histopathologic sections and bacterial culturing. | 1983 | 6846942 |
| long-term results of pulmonary resection for atypical mycobacterial disease. | from 1967 through 1981, 40 pulmonary resections were performed in 37 patients with mycobacterium intracellulare infection. the patients ranged in age from 24 to 67 years, and 86% were men. smoking and alcohol abuse seemed to be predisposing factors. localized atypical mycobacterial infection unresponsive to chemotherapy was the operative indication for 38 of the 40 resections. all patients had cavitary disease. mean length of preoperative drug treatment was 22 weeks. sensitivity studies showed a ... | 1983 | 6860003 |
| disseminated tuberculosis caused by mycobacterium intracellulare (update) | 1983 | 6861538 | |
| deoxyribonucleic acid relationships between different serovars of mycobacterium avium, mycobacterium intracellulare and mycobacterium scrofulaceum. | m. avium and m. intracellulare are difficult to distinguish by means of biochemical tests and by means of numerical taxonomy. dna-dna hybridization confirms that these species are different but indicates that some serovars of m. intracellulare actually belong to the species m.avium, viz.: serovars 4, 5, 6 and 8. this corresponds to results obtained with sensitin tests on guinea-pigs. the status of strains belonging to serovar 9 is uncertain. the two strains investigated in this study were closel ... | 1983 | 6880745 |
| purification and antigenic specificity of alpha protein (yoneda and fukui) from mycobacterium tuberculosis and mycobacterium intracellulare. | 1983 | 6190783 | |
| community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men. | fourteen previously healthy young patients with unusual community-acquired opportunistic infections were seen over a period of three years. they differ from patients previously described in that 11 were heterosexual drug abusers (including two women) and only three were homosexual men. there were eight puerto ricans, five blacks, and one white. infections included pneumocystis carinii pneumonia (seven), disseminated mycobacterium intracellulare infection, histoplasmosis, cryptococcosis, and cyto ... | 1983 | 6219579 |
| mechanism of antibiotic resistance in mycobacterium intracellulare. | the mechanism of resistance of mycobacterium intracellulare strain 103 and other clinical isolates to a variety of drugs including aminoglycoside and peptide antibiotics was investigated. enzymatic inactivation of aminoglycoside and peptide antibiotics could not be demonstrated. ribosomes of the strain were found to be sensitive to the antibiotics. the levels of resistance of strain 103 and other clinical isolates decreased dramatically when the culture medium was changed from dubos agar to twee ... | 1983 | 6312275 |
| in vitro response of murine alveolar and peritoneal macrophages to mycobacterium intracellulare. | normal resident and bcg-activated alveolar and peritoneal macrophages from female swiss webster mice were compared for their ability to ingest and subsequently control the multiplication of mycobacterium intracellulare in vitro. resident peritoneal macrophages failed from the moment of ingestion to control the multiplication of engulfed bacilli resulting in host cell lysis, whereas activated peritoneal macrophages and both resident and activated alveolar macrophages constrained bacterial divisio ... | 1983 | 6359986 |
| effects of bacterial immunopotentiators, lc 9018 and ok-432, on the resistance against mycobacterium intracellulare infection in mice. | 1983 | 6408030 | |
| resistance of various strains of mycobacteria to killing by activated macrophages in vivo. | a variety of experimental infections with pathogenic mycobacteria are associated with the development of persistent disease, in which little or no changes in the numbers of the infectious organism can be detected. this report describes a simple experimental model designed to test the hypothesis that this persistence may reflect in part the ability of these organisms to resist the enhanced bacteriostatic and bactericidal properties acquired by host macrophages as a result of these mycobacterial i ... | 1983 | 6411817 |
| genetic control of resistance to mycobacterium intracellulare infection in mice. | the susceptibilities of various strains of mice to a highly pathogenic strain of mycobacterium intracellulare, the mino strain, were determined by intravenous injection of 5 x 10(6) bacteria. cfu were counted on days 1 and 21 of infection. among 10 strains of mice, c57bl/6, c57bl/10, balb/c, b10.br, b10.a, and b10.d2 were susceptible, whereas dba/2, a/j, cba, and c3h/he were resistant. in the susceptible mouse strains, the number of bacteria increased during 21 days of infection, whereas no bact ... | 1984 | 6480104 |
| [osteoarthritis and tenosynovitis of the finger due to mycobacterium intracellulare. a case report and review of the literature]. | the authors present one case of osteo-arthritis and tenosynovitis of the right forefinger due to mycobacterium intracellulare, in a 61-year old woman. the treatment consists of a synovectomy of the finger's proximal interphalangeal joint and of the sheath of the flexor tendons and a drug regimen associating erythromycin and cotrimoxazole for 2 1/2 months. this therapy proves successful, as the patient is clinically cured. a literature review records 19 similar osteo-articular and peri-articular ... | 1984 | 6504574 |
| light and electron microscopic observations on granulomatous lesions in pigs dosed with mycobacterium intracellulare. | the histology and ultrastructure of the granulomatous lesions were studied in 18 pigs dosed orally with mycobacterium intracellulare serotype 8. the pigs were killed 2, 4, 6, 8 and 12 weeks after dosing. histologically, initial granulomatous lesions were seen in the tonsils 6 and 8 weeks after dosing. initial or more advanced granulomatous lesions were observed in the tonsils and lymph nodes (mandibular, jejunal, ileocolic and superficial inguinal) 12 weeks after dosing. the initial granulomatou ... | 1984 | 6512025 |
| mycolic acid patterns of some species of mycobacterium. | representative strains of some species of mycobacterium were degraded by both acid and alkaline methanolysis. two-dimensional thin-layer chromatography was used to determine the patterns of mycolic acids and other long-chain components in these methanolysates. patterns composed of alpha-, methoxy- and ketomycolates were found in mycobacterium asiaticum, mycobacterium bovis, mycobacterium gastri, mycobacterium gordonae, mycobacterium kansasii, mycobacterium marinum and mycobacterium tuberculosis; ... | 1984 | 6517656 |
| [chemotherapy of lung disease due to mycobacterium avium-mycobacterium intracellulare complex by a combination of sulfadimethoxine, minocycline and kitasamycin]. | 1984 | 6716752 | |
| avian tuberculosis in pigs: mycobacterium intracellulare infection in a breeding herd. | lymphadenitis of pigs caused by mycobacterium intracellulare is widely recognised in continental europe but this is the first report of it in england. no disease was seen on the farm but condemnations of tissues and organs at the slaughterhouse were often than 100 a week and in one week were in excess of 200. the loss was greater to the slaughterhouse than to the farmer because of the constant disruption to the production line. there was no evidence that diseased pigs performed less well than he ... | 1984 | 6740882 |
| disseminated atypical mycobacteriosis. | two cases of disseminated infection caused by mycobacterium intracellulare were reported and discussed. in the first case, the patient was a fifty-seven-year-old male who complained of general fatigue, weight loss, and fever. biopsy of the right inguinal lymph nodes and the liver revealed infiltration by histiocytes engulfing many acid-fast bacilli. at autopsy and egg-sized abscess was found is the region of the right iliac lymph nodes. histological examination showed histiocytic infiltration in ... | 1984 | 6741553 |
| in vitro susceptibility of human and environmental isolates of mycobacterium avium, m. intracellulare, and m. scrofulaceum to heavy-metal salts and oxyanions. | because of the widespread distribution of mycobacterium intracellulare and m. scrofulaceum in southeastern u.s. waters, the susceptibility of members of these species to heavy-metal salts and oxyanions was investigated. isolates with abnormally high tolerance to mercuric chloride or cadmium chloride were identified. | 1984 | 6230989 |
| release of superoxide anion from resident and activated mouse peritoneal macrophages infected with mycobacterium intracellulare. | phagocytosis of mycobacterium intracellulare triggered the release of superoxide anion (o-2) from mouse peritoneal macrophages; the amount release from bcg-activated cells was significantly greater than that from resident cells. superoxide anion release was proportional to the number of phagocytes ingesting bacilli. an optimal phagocytic time course of 4 h was observed when estimating o-2 release consequent to bacterial challenge. also, an inverse relationship between the amount of o-2 released ... | 1984 | 6093657 |
| [a study on experimental mycobacterioses provoked by atypical mycobacteria. trials in airborne infection of mice with mycobacterium intracellulare. (2)]. | 1984 | 6748454 | |
| susceptibility of mycobacterium intracellulare to hydrogen peroxide. | the susceptibility to h2o2 of 5 strains of mycobacterium intracellulare and both catalase-positive (tmc 102) and negative (tmc 303) strains of m. tuberculosis, h37rv, was tested at ph 7.0 and 4.0. all strains of m. intracellulare were significantly more resistant to this oxygen metabolite than were the two m. tuberculosis strains, even though the catalase activity of m. tuberculosis tmc 102 was higher than most m. intracellulare strains. even the catalase negative (eggeman) strain of m. intracel ... | 1984 | 6431858 |
| a prospective study of lung disease caused by mycobacterium avium/mycobacterium intracellulare. | this is a prospective study of 36 patients with lung infections caused by m. avium/m. intracellulare. the division of the patients into 2 prognostic groups ("good"/"others"), and the guidelines for their treatment are based on a previous report (3). the criteria for the division were co-existing lung disease and dyspnoea on admittance. the patients in group "good" were treated with isoniazid, rifampicin and ethambutol, in group "others" these were supplemented with one or more drugs. as in the p ... | 1984 | 6468544 |
| induction of bacteriophage from members of the mycobacterium avium, mycobacterium intracellulare, mycobacterium scrofulaceum serocomplex. | bacteriophages have been induced from strains in the mycobacterium avium, mycobacterium intracellulare, mycobacterium scrofulaceum serocomplex by exposure of cultures to uv light or treatment with mitomycin c. one-sixth of the strains examined, representing all but one of the 31 authenticated serotypes, were found to possess phages lytic for a mycobacterium smegmatis indicator strain. four single-plaque isolated phages, tm4, tm9, tm10 and tm20, were purified and shown to have a similar morpholog ... | 1984 | 6470677 |
| restriction endonuclease mapping and cloning of mycobacterium intracellulare plasmid plr7. | a restriction map of mycobacterium intracellulare plasmid plr7 was developed. this 15.3-kb plasmid had unique sites for bamhi, hindiii, and xbai. various large fragments of plr7 were cloned into pbr322 or php34 and propagated in escherichia coli. a hybrid plr7 ::pbr322 plasmid carrying the complete plr7 sequence was constructed by joining the plasmids at their hindiii sites. the construction of these hybrids will facilitate the analysis and manipulation of plr7 and may allow the development of t ... | 1984 | 6329910 |
| mycobacterium avium-mycobacterium intracellulare from the intestinal tracts of patients with the acquired immunodeficiency syndrome: concepts regarding acquisition and pathogenesis. | 1985 | 3965590 | |
| [a case of pulmonary infection due to mycobacterium intracellulare developing after pulmonary embolism]. | 1985 | 4032950 | |
| isolation, identification, and structural analysis of the mycobactins of mycobacterium avium, mycobacterium intracellulare, mycobacterium scrofulaceum, and mycobacterium paratuberculosis. | methods were devised to purify the cell-associated, iron-binding compounds known as mycobactins from the closely related species mycobacterium avium, mycobacterium intracellulare, and mycobacterium scrofulaceum (i.e., the mais complex of organisms). the mycobactins from these three species showed a structure that is common to the mycobactins from all the mycobacteria examined to date. however, these mycobactins were unique in that they had more than one alkyl chain. the m. scrofulaceum mycobacti ... | 1985 | 4055700 |
| synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against mycobacterium species. | a series of compounds, which are analogues of 2,2'-dithiobis(benzamide), were synthesized and tested for in vitro antibacterial activity against mycobacterium tuberculosis h37rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide. mics of these compounds against atypical mycobacteria, mycobacterium kansasii and mycobacterium intracellulare were also examined. structure-activity relationships were found in a series of (acyloxy)alkyl ester derivatives depend ... | 1985 | 3934384 |
| humoral response to disseminated infection by mycobacterium avium-mycobacterium intracellulare in acquired immunodeficiency syndrome and hairy cell leukemia. | antibody to mycobacterium avium-mycobacterium intracellulare antigen was measured by immunodiffusion, enzyme-linked immunosorbent assay (elisa), and indirect immunofluorescence in sera from 30 patients with acquired immunodeficiency syndrome (aids), 10 patients with hairy cell leukemia, and 33 hospitalized and healthy controls. ten patients with aids and three patients with hairy cell leukemia in the study population had disseminated m. avium-m. intracellulare infection. patients with aids and d ... | 1985 | 3919112 |
| dynamic aspects of the in vitro chemotherapeutic activity of ansamycin (rifabutine) on mycobacterium intracellulare. | the in vitro action of ansamycin against mycobacterium intracellulare was studied using continuous, dynamic (a rapidly falling off concentration simulating that existing in vivo in humans), and pulsed exposures. ansamycin at a concentration of 5 micrograms/ml showed bactericidal activity starting from as early as 3 days after constant exposure. in the dynamic model with the drug present in bactericidal concentration for only 2 h a day, bactericidal activity was demonstrated. with pulsed exposure ... | 1985 | 4073667 |
| comparative in vitro activities of mdl 473, rifampin, and ansamycin against mycobacterium intracellulare. | the susceptibilities of 20 clinical isolates of mycobacterium intracellulare to rifampin, mdl 473, and ansamycin were determined by broth and agar dilution methods. ansamycin was more active than mdl 473, which in turn was usually more active than rifampin by either method. the mics for 90% of the strains tested by agar dilution were 1, 2, and 4 micrograms of ansamycin, mdl 473, and rifampin per ml, respectively. | 1985 | 4073865 |
| [lymph node non-tuberculous mycobacteriosis caused by mycobacterium intracellulare]. | 1985 | 4085025 | |
| enzyme-linked immunosorbent assay of glycolipid antigens for identification of mycobacteria. | enzyme-linked immunosorbent assays which are based on species- or type-specific glycolipids antigens and in which rabbit antisera are prepared with homologous strains are capable of distinguishing among serological variants of the mycobacterium avium-mycobacterium intracellulare-mycobacterium scrofulaceum complex, mycobacterium chelonei subspecies chelonei and abscessus, mycobacterium simiae i and ii, mycobacterium kansasii, mycobacterium szulgai, mycobacterium xenopi, and mycobacterium fortuitu ... | 1985 | 3886692 |
| tuberculous osteomyelitis caused by mycobacterium intracellulare in the brush-tailed bettong. | 1986 | 3735593 | |
| haptenic oligosaccharides in antigenic variants of mycobacterial c-mycosides antagonize lipid receptor activity for mycobacteriophage d4 by masking a methylated rhamnose. | the simple apolar c-mycosides, i.e., structurally well-defined hydrophobic glycopeptidolipids of several mycobacterium species (see diagram below), were earlier shown to behave as receptors for adsorption of mycobacteriophage d4. this phage is usually virulent for mycobacterium smegmatis. more complex, polar c-mycosides with additional carbohydrate substituents attached solely to the deoxytalose have recently been described. they are the highly specific serotyping antigens discovered by w. b. sc ... | 1986 | 3759906 |
| oxidative and phagocytic functions of macrophages during infections induced in mice by mycobacterium intracellulare and listeria monocytogenes. | the oxidative metabolism (chemiluminescence and h2o2 release) and phagocytic activity of mouse peritoneal macrophages during chronic infections induced by mycobacterium intracellulare and more acute infections due to listeria monocytogenes were studied. in m. intracellulare infections, macrophage chemiluminescence in response to phorbol myristate acetate (pma) was greatest at around 2 weeks, with a 1 week lag phase after infection, while the pma-triggered h2o2 release was markedly enhanced even ... | 1986 | 3760821 |
| taxonomic differences between mycobacterium avium and mycobacterium intracellulare elucidated in man by skin tests with three new tuberculins. | new tuberculins called aviumins a, b and c prepared from m. avium, its proposed subspecies m. avium brunense and m. intracellulare respectively have been skin tested on school children in six countries as a part of larger studies. the results show that the reagents are recognised separately in most cases by the human immune system. although there is some significant interdependence in sensitization to these reagents, the frequency of meeting the organisms must be very high since 33% of children ... | 1986 | 3780895 |
| macrophage uptake and retention of radiolabeled glycopeptidolipid antigens associated with the superficial l1 layer of mycobacterium intracellulare serovar 20. | glycopeptidolipid (gpl) antigens which are associated with the superficial l1 layer of mycobacterium intracellulare serovar 20 were labeled with radioisotopes by means of internal labeling techniques and used in macrophage uptake and retention studies. the use of tritiated alanine and phenylalanine allowed the incorporation of label into the gpl invariant fatty acyl peptide core, which is common to all members of the mycobacterium avium-m. intracellulare complex. radiolabeled gpl antigens were t ... | 1986 | 3531012 |
| [sensitivity of mycobacterium intracellulare and mycobacterium kansasii to antituberculous drugs]. | 1986 | 3582058 | |
| chronic infection due to mycobacterium intracellulare in mice: association with macrophage release of prostaglandin e2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-gamma. | as a model for the study of human atypical mycobacterial disease, we explored the basis for the prolonged mycobacteriosis in mice infected with mycobacterium intracellulare. two weeks after i.v. injection of mycobacteria, peritoneal macrophages were found to be activated, as indicated by their capacity to produce large amounts of superoxide anion (o2-) in response to phorbol myristate acetate (pma) or viable m. intracellulare. however, 4 wk after infection, despite the continued presence of larg ... | 1986 | 3005400 |
| opportunistic infections in patients with aids: clues to the epidemiology of aids and the relative virulence of pathogens. | the frequency of nine reactivating or opportunistic infections and kaposi's sarcoma among patients with the acquired immunodeficiency syndrome (aids) was reviewed. the diagnoses of 87 patients reported from the colorado aids registry and 359 others from literature reports were abstracted, and data were placed in one of 11 categories on the basis of the risk group of the patient. pneumocystis carinii infection was significantly commoner among blood or blood-product recipients than among natives o ... | 1986 | 3006206 |
| comparative in vitro activities of ciprofloxacin and other 4-quinolones against mycobacterium tuberculosis and mycobacterium intracellulare. | the in vitro activity of ciprofloxacin, ofloxacin, amifloxacin, and norfloxacin against 22 clinical isolates of mycobacterium tuberculosis was evaluated by agar dilution. the mics for 90% of the isolates of ciprofloxacin and ofloxacin were 0.5 and 1 microgram/ml, respectively. amifloxacin and norfloxacin were less active. the mics for 90% of the isolates of ciprofloxacin and ofloxacin against 20 clinical isolates of mycobacterium intracellulare were determined by agar dilution to be 2 and 8 micr ... | 1986 | 2940969 |
| selective enzyme staining procedures for characterization of mycobacterial immunoprecipitates. | selective staining procedures for four different enzymes (malate dehydrogenase, glutamic oxaloacetic transaminase, leucine aminopeptidase and glucose phosphate isomerase) in combination with two-dimensional immunoelectrophoresis were successfully applied to the analysis of antigen preparations from mycobacteria. thus, a precipitate corresponding to malate dehydrogenase could e.g. be demonstrated in multi-linear precipitation patterns of mycobacterium avium, mycobacterium bovis bcg, mycobacterium ... | 1986 | 2417958 |
| serologic and cellular cross-reactivity of fractions of mycobacterium intracellulare (battey). | sonicates of mycobacterium intracellulare grown in synthetic medium were separated into ammonium sulfate (50%) precipitable and nonprecipitable fractions. gel filtration of the precipitable fraction through columns of sephacryl s-300 resulted in four fractions labeled a, b, c and d in order of elution. fractions c and d were further fractionated into 12 and 13 subfractions, respectively. the subfractions were examined for reactivity by rocket immunoelectrophoresis (r-ie) procedures and by skin t ... | 1986 | 2439398 |
| the relationship between immunodiffusion and agglutination serotypes of mycobacterium avium and mycobacterium intracellulare. | twenty mycobacterium avium/intracellulare strains of diverse origins and two reference strains of each of schaefer's serotypes 1-21 were examined by immunodiffusion analysis. the results produced three distinct groups, which we have called a, b and c. two of these, a and b, appear to be variants, perhaps subspecies of m. avium, and group c is m. intracellulare. within each group, rough variants, untypable by schaefer's agglutination method, were found to be antigenically identical to the smooth ... | 1986 | 3096757 |
| successful management of mycobacterium intracellulare pneumonia in a child. | 1986 | 3952014 | |
| attenuated mycobacterium lepraemurium vaccine non-protective against mycobacterium intracellulare infection in mice. | 1986 | 3528063 | |
| mycobacterial plasmids: screening and possible relationship to antibiotic resistance in mycobacterium avium/mycobacterium intracellulare. | 1986 | 3540539 | |
| a thin gel layer technique for improved resolution in two-dimensional immunoelectrophoresis. | a modification of the two-dimensional (crossed) immunoelectrophoresis (2d-ie) method characterized by the employment of a thin gel layer (0.3 mm) was developed. a rectangular millipore filter dehydrates an area of the gel, thereby forming a basin which is charged with antiserum by means of a special applicator. this 2d-ie technique was compared with the techniques by weeke [scand. j. immunol. 2: suppl. 1, pp. 47-56, 1973] and by lebecq et al. [j. immunol. methods 66: 219-226, 1984] using a model ... | 1986 | 3943915 |
| plasmid dna profiles as epidemiological markers for clinical and environmental isolates of mycobacterium avium, mycobacterium intracellulare, and mycobacterium scrofulaceum. | plasmid dna was isolated, and profiles of a variety of clinical and environmental isolates of mycobacterium avium, mycobacterium intracellulare, and mycobacterium scrofulaceum (mais) were compared to determine whether plasmid dna content would be useful as an epidemiological marker for these environmental pathogens. since plasmids are common in clinical isolates and are stable during culture and exposure to naoh, plasmid dna analysis appears to be a suitable epidemiological tool. based on the hi ... | 1986 | 3944484 |
| coexistent mycobacterium intracellulare gonarthritis and patellar osteomyelitis in a patient with pulmonary sarcoidosis. a case report and literature review. | we present a 48-year-old man with known pulmonary sarcoidosis who developed septic arthritis of the left knee with concomitant patellar osteomyelitis due to mycobacterium intracellulare. the patient underwent synovectomy and was started on appropriate combination chemotherapy, but clinical improvement did not occur until patellectomy was performed. both bone and radiogallium scans were important in the medical and surgical management of this patient. | 1986 | 3960781 |
| characterization of mycobacterium paratuberculosis by gas-liquid and thin-layer chromatography and rapid demonstration of mycobactin dependence using radiometric methods. | thirty-six mycobacterium paratuberculosis isolates of bovine, caprine, and ovine origins were evaluated by using gas-liquid chromatography (glc), thin-layer chromatography (tlc), and bactec 7h12 middlebrook tb medium (12a; johnston laboratories, inc., towson, md.) in an effort to more rapidly differentiate this group of organisms from other mycobacteria. bacterial suspensions (0.1 ml) were inoculated by syringe into 7h12 broth containing 2 micrograms of mycobactin p per ml and control broth with ... | 1987 | 3429629 |
| [a case of thrombosis occurring in the main trunk of the pulmonary arterial trees with pulmonary infection due to mycobacterium intracellulare]. | 1987 | 3694968 | |
| detection of mycobacterium avium-mycobacterium intracellulare in blood cultures using concentrated and unconcentrated blood in conjunction with a radiometric detection system. | studies were performed in order to determine optimal methods for isolating mycobacteria from blood. the combined use of a lysis-centrifugation (isolator) system and a radiometric-detection system (bactec) was compared to the use of either unconcentrated blood or centrifuged blood pellet in conjunction with the bactec mycobacterial system. results showed that for cultures with greater than 10 colony forming units (cfu) per ml of blood, the use of unconcentrated blood and centrifuged blood pellet ... | 1987 | 3545654 |
| effect of rifabutin on the phagocytosis and intracellular growth of mycobacterium intracellulare in mouse resident and activated peritoneal and alveolar macrophages. | in order to understand the discrepant results between in vitro and in vivo activity of rifabutin (lm 427) against mycobacterium intracellulare, we studied its effects upon the phagocytosis of m. intracellulare by resident and activated mouse peritoneal and alveolar macrophages and upon growth of m. intracellulare inside these cells. rifabutin (ansamycin, lm 427) had no effect on the viability of resident or activated peritoneal or alveolar macrophages or on the phagocytosis of m. intracellulare ... | 1987 | 3039880 |
| mycobacteria other than mycobacterium tuberculosis: review of microbiologic and clinical aspects. | the rate of isolation of mycobacteria other than mycobacterium tuberculosis (mott) has increased over the past several years; in some areas the isolation rate for mycobacterium avium-mycobacterium intracellulare has surpassed that for m. tuberculosis. simultaneously, the spectrum of clinical manifestations with the various species has widened. outbreaks of disease due to mycobacterium chelonae have occurred in renal dialysis patients. new species have been described: mycobacterium malmoense is p ... | 1987 | 3296098 |
| mycobacterial antigen detection by immunohistochemistry in pulmonary tuberculosis. | a preliminary diagnosis of tuberculosis can be established by the detection of acid-fast bacilli (afb) and confirmed by culture of the microorganism. to evaluate an alternative method of diagnosis, the distribution of mycobacterial antigens in lung tissue specimens was characterized by an indirect peroxidase-antiperoxidase method and was compared to the detection of afb by ziehl-neelsen stain. histologic specimens were obtained from 59 hospital patients. of nine patients with mycobacterial disea ... | 1987 | 3297995 |
| the simultaneous inoculation of mycobacterium leprae and m. intracellulare into nude mice: development of cutaneous leproma and accelleration of foot pad swelling. | organisms of the non-pathogenic mycobacterium intracellulare serotype 19 darden enhanced the pathogenicity of m. leprae when inoculated together into the foot pads of nude mice. this supporting effect could be demonstrated by an accelleration of foot pad swelling, beginning 4 months after inoculation and by the development of cutaneous leproma on dorsal and lateral body sites within 6 months after inoculation. these leproma increased in number and size during the 9 months they were under observa ... | 1987 | 3330554 |
| the use of dna probes identifying restriction-fragment-length polymorphisms to examine the mycobacterium avium complex. | dna probes were used to identify restriction-fragment-length polymorphisms (rflps) in dna samples, demonstrating that the mycobacterium avium complex could be clearly divided into m. avium and mycobacterium intracellulare strains. less than 2% dna base substitution was found between m. avium strains, whereas the m. intracellulare strains had greater than 15% base substitution. the johne's disease bacillus, mycobacterium paratuberculosis (american type strain), was found to be distinguishable fro ... | 1987 | 2896288 |
| activity of rifabutin alone or in combination with clofazimine or ethambutol or both against acute and chronic experimental mycobacterium intracellulare infections. | rifabutin (ansamycin lm 427) when given alone in doses of 5, 10, or 20 mg/kg showed limited in vivo activity against acute or chronic mycobacterium intracellulare infections studied in beige c57b1/6, or s/w mice. prophylactic studies in s/w mice in which chemotherapy was given for 3 wk prior to challenge showed slight improvement. combination chemotherapy consisting of rifabutin (10 mg/kg) and clofazimine (20 mg/kg) achieved complete sterilization of m. intracellulare infections in spleen and lu ... | 1987 | 3039879 |
| rapid identification using a specific dna probe of mycobacterium avium complex from patients with acquired immunodeficiency syndrome. | specific dna probes (gen-probe corp., san diego, calif.) for mycobacterium avium, mycobacterium intracellulare, and mycobacterium tuberculosis were compared with conventional methods for the identification of isolates of the mycobacterium avium complex. a total of 56 isolates of m. avium complex were recovered from 34 respiratory, 13 blood, 6 stool, and 3 urine samples from 23 patients. a total of 33 isolates were tested directly from middlebrook 7h11 agar plates, and 23 isolates were tested dir ... | 1987 | 3624446 |
| characterization of mycobacterial immunoprecipitates by selective staining of enzymes. | immune precipitation patterns of mycobacterium intracellulare, m. phlei and m. smegmatis were analysed by selective enzyme staining procedures in order to characterize individual mycobacterial antigens. enzyme activity was shown in eight precipitinogens of m. intracellulare, seven of m. phlei, and six of m. smegmatis. the identification of mycobacterial precipitinogens as enzymes is important since only a few mycobacterial antigens have been functionally characterized. | 1987 | 3668506 |
| [epidemiology of infection by mycobacterium intracellulare. sensitivity to ppd rt23 and ppd-b in certain parts of china]. | 1987 | 3622148 | |
| effect of combined clofazimine and ansamycin therapy on mycobacterium avium-mycobacterium intracellulare bacteremia in patients with aids. | 1987 | 3794396 | |
| production and characterization of serovar-specific monoclonal antibodies to serovars 4, 8, and 9 of mycobacterium intracellulare. | serovar-specific monoclonal antibodies against mycobacterium avium-mycobacterium intracellulare-mycobacterium scrofulaceum complex serovars 4, 8, and 9 were prepared. nine, four, and one monoclonal antibodies, respectively, to the serovars were prepared by the usual cell fusion technique. all nine monoclonal antibodies to serovar 4 were monospecific for their homologous serovar and reacted with several native glycopeptidolipids (gpls) and one major deacylated gpl from the homologous serovar. one ... | 1987 | 3818094 |
| the presence of novel glucuronic acid-containing, type-specific glycolipid antigens within mycobacterium spp. revision of earlier structures. | previously, we had described the structures of the haptenic oligosaccharides of the surface glycopeptidolipid antigens from serotypes 9 and 25 of the mycobacterium avium complex and had synthesized these units as putative antigenic probes. the lack of chemical concordance between the synthetic products and the haptens has prompted a re-examination of these structures utilizing the instrumental techniques not previously available of fast atom bombardment-mass spectrometry, fourier transform infra ... | 1987 | 3818654 |
| [clinical trial of forphenicinol for the lung infection with mycobacterium avium, mycobacterium intracellulare complex]. | clinical evaluation of forphenicinol, a low molecular weight immunomodulator, in patients with mycobacterium avium, mycobacterium intracellulare complex pulmonary infections has been conducted in a multicenter trial participated by 9 institutions in kyushu during a period of 12 months from july 1982 to august 1983. forphenicinol was administered for 6 months without changing the regimen of antituberculous drugs used previously. the following results were obtained. 1. ten out of 33 eligible patie ... | 1987 | 3302344 |
| intrinsic catalase dot blot immunoassay for identification of mycobacterium tuberculosis, mycobacterium avium, and mycobacterium intracellulare. | the heat-labile t class of mycobacterial catalase exhibits peroxidase activity with some substrates. most species of mycobacteria produce t-catalase, which is serologically characterized by a combination of shared epitopes and unique, species-specific epitopes. antibodies to t-catalases from mycobacterium tuberculosis, mycobacterium avium, and mycobacterium intracellulare have been cross absorbed with t-catalases from heterologous species and applied as dots to nitrocellulose membranes. when the ... | 1987 | 2443531 |
| characterization of serologic and cell-mediated reactivity of a 38-kda antigen isolated from mycobacterium tuberculosis. | an antigen of mycobacterium tuberculosis with an m.w. of 38,000 has been isolated by affinity chromatography using a monoclonal antibody. this antibody bound only to an antigen found in m. tuberculosis and mycobacterium bovis bcg. the specificity of the antigen was tested in a vertical study by immunodetection on western blots reacted with hyperimmune sera against m. tuberculosis, m. bovis, and 10 other mycobacterium species. the antigen was detected only by antisera to m. tuberculosis and m. bo ... | 1987 | 2443566 |
| t lymphocyte responses to mycobacterial antigen in aids patients with disseminated mycobacterium avium-mycobacterium intracellulare infection. | patients with acquired immunodeficiency syndrome (aids) who have mycobacterium avium-mycobacterium intracellulare (mai) infection typically have widely disseminated disease, often fail to respond to multi-drug chemotherapeutic regimens, and show little or no inflammatory tissue response. to determine if this clinicopathologic state correlates with in vitro lymphocyte responses to specific antigen, peripheral blood mononuclear cells from 18 patients with aids who had mai bacillemia were stimulate ... | 1988 | 3129241 |
| detection of a novel catalase in extracts of mycobacterium avium and mycobacterium intracellulare. | a novel class of catalase, which differs from the previously described m- and t-catalases of mycobacteria, was detected in strains of mycobacterium avium and m. intracellulare. designated a-catalase, this enzyme resisted inactivation at 68 degrees c, was inactivated by 3-amino-1,2,4-triazole (aminotriazole), and exhibited no peroxidase activity. all of these properties distinguished the enzyme from t-catalase. the a-catalase exhibited a km of 70 mm h2o2, which is between the upper and lower extr ... | 1988 | 3346077 |
| further studies on colistin (polymyxin e)-induced cell leakage in mycobacteria: mg++ efflux in mycobacterium avium and its effects on drug-susceptibility. | action of colistin (polymyxin e) was investigated on the opportunistic pathogenic species mycobacterium avium atcc 15769 (resistant strain, mic greater than 100 micrograms/ml). mycobacterium intracellulare atcc 13950: a colistin-susceptible strain (mic 25 micrograms/ml), was used as a parallel control for mg++ efflux experiments. after the addition of 100 micrograms/ml of colistin to bacteria suspended in a buffer, both loss of viability and mg++ efflux were followed for one week. although there ... | 1988 | 3394452 |