Publications

isolation of tubercle bacteria using ogawa egg medium modified by addition of tween 80.	a modified medium was developed by altering the composition of 3 per cent ogawa egg medium and adding tween 80. isolation of tubercle bacilli using this medium, in general, showed better growth and colines became visible earlier than the original medium, but there was no improvement in the positive rate.	1978	104475
[lymph node tuberculosis--today].	the peripheral tuberculosis of the lymph nodes on the neck, in the axilla and on the groin is described in its present epidemiological situation, its pathogenesis, diagnosis and therapy. nowadays the tuberculosis of the lymph nodes most frequently occurs at older age and in women. in most cases the m. tuberculosis is the causative organism. the differential diagnosis must take into consideration many possibilities and sources of error--also for the following therapy and expert opinion--, in most ...	1978	104459
[action of preparation k and its components on the causative agent of tuberculosis].		1978	104131
organization of allergic granulomas and dependence on insoluble antigen.		1978	104033
immunological method to differentiate between antigens of tubercle bacilli, other mycobacterial species, and non-acid-fast bacteria.	sera from rabbits immunized with sonicates of mycobacterium bovis bcg were passed through an immunoadsorbent made of a soluble bcg extract to make partially purified antibodies to bcg. these antibodies were in turn used to prepare an immunoadsorbent through which the bcg extract was passed. the partially purified antigenic material was radiolabeled and subjected to electrophoresis in acrylamide gels. one of the radiolabeled fractions isolated (bcg-c) was found to bind to antibodies to bcg and h3 ...	1978	103823
incidence of pulmonary tuberculosis and change in bacteriological status of cases at shorter intervals.		1978	103812
pharmacologic factors and manipulation of immunity systemic adjuvants in cancer therapy.	because of the experimental and clinical studies which have been extensively conducted with bacillus calmette-guérin (bcg) as a systemic adjuvant in cancer immunotherapy, we have analyzed the main factors and conditions which determine its beneficial action and have underlined some of these (eg, the dose factor which controls the amplification of suppressor cells which is probably responsible for failures and even the possible tumor-enhancing effect of immunotherapy). knowing those factors and c ...	1978	103616
isolation of tuberculin peptides from tuberculin purified protein derivative (ppd).	tuberculin purified protein derivative (ppd) obtained from the filtrate of mycobacterium tuberculosis was hydrolysed with proteinase, trypsin, or chymotrypsin. each hydrolysate consisted of a tuberculin peptides mixture (tpm). from each tpm 16 fractions were obtained by ion-exchange chromatography on dowex 50w-x8 but only one fraction was isolated from each of the 16 fractions which showed tuberculin activity in guinea pigs sensitized with m. bovis (bcg) or m. tuberculosis. this fraction was des ...	1978	103608
[special aspects of tuberculosis in exposed personnel].		1978	103203
[acquired resistance of mycobacterium tuberculosis to rifampicin].		1978	103148
[pathomorphology of tuberculous and post-tuberculous changes depending on the l-transformation of mycobacteria in the patient's body].		1978	103092
[virulence of polyresistant strains of mycobacterium tuberculosis].		1978	103091
[healing of destructive pulmonary tuberculosis depending on bacteriostatic effect of various methods of treatment].		1978	103090
[mycobacteriophage typing of acid-fast strains isolated from patients in various provinces of poland].		1978	103079
[detection of pathogenic mycobacteria in the environment of the medical units and of the slaughter-house of an african town (author's transl)].	the authors have made investigations about the presence of pathogen mycobacteria in puddles of rain water and in rill waters of sanitary formations and municipal slaughter-house of yaoundé. 19 strains of pathogen mycobacteria have been isolated from 84 water samples : 15 m. tuberculosis strains, especially present in the environment of sanitary formations, 4 m. bovis strains, especially present in the environment of the slaughterhouse. the third part of isolated m. tuberculosis strains belongs t ...	1978	102900
antituberculous effect of some imidazole derivatives.		1978	102862
[a comparison of the time of in vivo resistance development of tubercle bacilli to rifampicin, kanamycin, ethionamide, lividomycin, and enviomycin (tuberactinomycin-n) in patients with chronic cavitary tuberculosis (author's transl)].		1978	102861
pott's disease in heroin addicts.	five cases of tuberculous vertebral osteomyelitis occurred in heroin addicts at st luke's hospital center between 1955 and 1975. all patients were men, and four were between 19 and 33 years of age. in contrast with the indolent onset typical to pyogenic or fungal vertebral osteomyelitis in heroin addicts, patients with pott's disease had an acute toxic reaction, with fever, back pain, weight loss, and night sweats. neurologic abnormalities, uncommon with pyogenic or fungal vertebral infection, o ...	1979	102808
tuberculous meningitis.	to evaluate modern treatment and identify important factors influencing the outcome of tuberculous meningitis, clinical and laboratory findings in 52 patients aged from 9 months to 68 years have been reviewed. patients were classified by clinical criterions at admission and at the start of treatment. delay in commencing treatment was associated with deterioration and consequently poorer prognosis, but some severely ill patients made a good recovery. forty-four survivors (85%) recovered, and only ...	1979	102806
[current status of the problem. i. epidemiology of tuberculosis].		1978	102388
pathobiodynamics: changes in ascorbate metabolism in rats with peripheral inflammation.		1978	102321
[comparative study of virulence of mycobacterium xenopi and other mycobacteria in the rabbit (author's transl)].		1978	102134
[catalases of mycobacteria as antigens. i. isolation, purification and characterization of catalases from different mycobacteria (author's transl)].	preparations of catalase isolated from the strains m. tuberculosis, m. kansasii and m. bovis bcg are produced for testing their antigenic activity. after desintegration of the bacteria the highest activity remained in the precipitation with 50% saturated ammonium sulphate solution. the further purification of the catalase-fractions occurred with the aid of column chromatography on sephadex g 200 and deae-sephadex-a 50 after ultrafiltration. in this way the relative activity increased in m. tuber ...	1978	102090
characteristics of hospitalized tuberculous patients today.	the characteristics of 149 patients with tuberculosis consecutively discharged from the tuberculosis service of the university of tennessee hospital in 1975 and 1976 were evaluated. the results of this study indicate the presence in this group of advanced age, alcohol abuse, debility from multiple chronic diseases, drug resistance, and recalcitrance. despite the unfavorable circumstances surrounding these patients, 118 patients showed bacteriologic and/or roentgenographic evidence of improvement ...	1978	102036
tuberculosis in south cleveland 1968--74. a laboratory based survey.		1978	102006
[biological properties of selected drug-resistant strains of mycobacterium tuberculosis].		1978	101985
[importance of bacteriological examinations for mycobacterium tuberculosis of certain groups of population with increased risk of contracting tuberculosis].		1978	101984
[recurrence of pulmonary tuberculosis in poland. 2. risk factors].		1978	101975
drug resistant tuberculosis in new zealand.	strains of m. tuberculosis resistant to one or more of the antituberculous drugs have not been common in new zealand in the past. there is however, a high incidence of drug resistant tuberculosis in western samoa, 50 percent of cultures tested showing drug resistance and half of these are resistant to two or more drugs. a change from the usual initial treatment is suggested for samoan patients with tuberculosis in new zealand.	1978	101915
[carbon metabolism in methylotrophic bacteria isolated from activated sludge].		1978	101747
isolation and characterization of the monounsaturated long chain fatty acids of mycobacterium tuberculosis.	the positions of double bond in the monounsaturated c15-c32 fatty acids of mycobacterium tuberculosis h37ra were established by gas chromatography/mass spectrometry of the ozonized esters and their pyrrolidide derivatives. the monounsaturated c15-c21 fatty acids had the double bond primarily at the delta 9 position while the monounsaturated longer chain fatty acids (c22-c32) had the double bond in several positions. many of the latter acids, especially the odd-numbered series, were very complex ...	1978	101728
induction of antitumor activity in mice presensitized with mycobacterium by immunization with tuberculin-coated tumor.		1978	101417
enhancing effect of coenzyme, q10 on immunorestoration with mycobacterium bovis bcg in tumor-bearing mice.	effect of the additional treatment with coenzyme q10 on immunorestoration with mycobacterium bovis bcg in tumor-bearing mice was investigated. cell-mediated cytotoxicity in tumor-bearing mice against alloantigenic tumor cells was determined by 51cr release assay using spleen cells of c57bl/6n mice which had been inoculated subcutaneously with syngeneic melanoma-b16 and immunized intraperitoneally with alloantigenic mastocytoma p815-x2 cells. the cell-mediated cytotoxicity against mastocytoma p81 ...	1978	101414
effect of oil-attached bcg cell-wall skeleton and thymectomy on the incidence of lung cancer and amyloidosis induced by chemical carcinogens in rabbits.	intravenous injection of oil-attached bcg cell-wall skeleton showed potent preventive activity for induction of lung cancer by the intrabronchial instillation of chemical carcinogens (3-methylcholanthrene, 4-nitroquinoline 1-oxide) in rabbits. on the other hand, the thymectomized rabbits developed lung cancer by instillation of chemical carcinogens at an 80% incidence, compared to 47.2% in the controls. there were no differences in the appearance of amyloidosis between thymectomized and bcg cell ...	1978	101411
primary antituberculous drug resistance in hawaii, 1957 to 1977.	a study of primary antituberculous drug resistance in hawaii was conducted from 1957 to 1977 to determine the incidence of primary resistance with respect to time. a total of 1,869 initial cultures of mycobacterium tuberculosis submitted to leahi hospital in honolulu were screened to identify drug resistance. of 256 patients who excreted resistant bacilli, only 55 had no history of previous antituberculous chemotherapy. the frequencies of primary drug resistance from july 1957 to july 1977 were ...	1978	101107
host-phage relationships in the genus mycobacterium and their clinical significance.	progress made during the last 15 years in the studies on the relationships between mycobacteria and their bacteriophages is reviewed. the basic biology of the phages and the applications of studies on adaptation and host range are discussed in relation to the development of phage typing systems for epidemiological purposes. the nature of lysogeny, its natural occurrence, its experimental establishment, the effect of the lysogenic state on the host bacterium and the evidence that lysogenic mycoba ...	1978	100919
comparison of various measures of sensitivity of m. tuberculosis to ethambutol.	a sensitivity test for ethambutol was standardised, and performed on cultures isolated from patients before and after the start of chemotherapy with ethambutol and isoniazid. a discrimination type of approach was employed and three criteria of resistance were evolved: (a) growth of 20 colonies or more on ethambutol 4 microgram/ml, using a standard inoculum; (b) a proportion of 25% or more on ethambutol 1.4 microgram/ml; (c) a proportion of 5% or more on ethambutol 2 microgram/ml. the mic definit ...	1978	100918
tuberculosis in kenya: a second national sampling survey of drug resistance and other factors, and a comparison with the prevalence data from the first national sampling survey. an east african and british medical research council co-operative investigation.	a survey was carried out in 1974 in the same random sample of 11 of 30 districts in kenya that were surveyed in 1964, to obtain information on (a) the proportion of patients with pulmonary and with extra-pulmonary tuberculosis, (b) the prevalence of bacteriologically-positive pulmonary tuberculosis, (c) the prevalence of initial and acquired drug resistance, (d) the radiographic extent and type of pulmonary disease, and (e) the changes that had occurred in the 10-year period. of 1490 patients, 8 ...	1978	100917
[immunological changes after bcg vaccination and infection with virulent mycobacterium tuberculosis].		1978	100780
[treatment of bronchial lesions in pulmonary tuberculosis with primary drug resistance of mycobacteria].		1978	100778
[experimental pulmonary cavity formation (author's transl)].		1978	100644
atypical mycobacteria.		1978	100630
rodent malaria: bcg-induced protection and immunosuppression.	one dose of 10(7) viable units of mycobacterium bovis, strain bcg, protected a significant number of swiss mice from a primary challenge with 10(4) thoracic sporozoites of plasmodium berghei. immunization with irradiated sporozoites induced greater protection than that observed in bcg-treated with bcg and surviving a primary sporozoite challenge were not protected from rechallenge, whereas mice immunized with irradiated sporozoites and surviving initial challenge of sporozoites were solidly immu ...	1978	100553
enzymatic and immunological characterization of the mycobacterium fortuitum complex.	the arylsulfatase isozymes of mycobacterium fortuitum, m. peregrinum, m. chelonei subsp. chelonei, and m. chelonei subsp. abscessus were examined to determine the isozymal and immunological relationship among the members of the m. fortuitum complex. cell extracts were subjected to electrophoresis on agarose and polyacrylamide gel, and arylsulfatase activity was localized using beta-naphthyl sulfate as substrate. unique zymograms were produced for m. fortuitum, m. peregrinum, and m. chelonei whic ...	1978	100510
[nomenclature of tuberculosis bacilli. the status of bcg. tuberculins and other mycobacterins].		1978	100221
an assessment of the place of follow-up pulmonary tuberculosis.	i n 1971--4 forty-four patients were found to have drug-susceptible tubercle bacilli in their sputum more than one year after a previous positive result. comparison of their case records with those of 45 controls showed that inadequate chemotherapy was by far the most important cause of relapse. most patients who have had adequate chemotherapy for pulmonary tuberculosis should be discharged. patients who have certain risk factors or who have had inadequate or irregular chemotherapy should be fol ...	1978	100128
controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis. first report.	four short-course antituberculosis regimens allocated at random were studied; (1) streptomycin, isoniazid, and rifampin given daily for 6 months; (2) these 3 drugs plus pyrazinamide given daily for 2 months, followed by twice-weekly administration of streptomycin, isoniazid, and pyrazinamide; (3) a regimen that differed from regimen 2 only in that ethambutol replaced pyrazinamide, and (4) streptomycin plus isoniazid plus rifampin plus pyrazinamide given 3 times per week for 4 months, followed by ...	1978	100029
tuberculosis infection and the repeat test. effect in bcg-vaccinated guinea pigs.	groups of bcg-vaccinated guinea pigs were infected with mycobacterium tuberculosis and the course of tuberculin reactions before and after was studied. the infection led to reactions that were accelerated as if repeated tests had been given, but were larger than in such cases. acceleration of reactions due to previous testing was present 1 week, but not 4 weeks after the start of the infection. possibly, in cellular immunity in general, absence of the repeat test effect may be interpreted as a s ...	1978	99809
[pilot trial of a short-term treatment of leprosy by combined chemotherapy and immunotherapy].		1977	99787
[prediction of time of terminating chemotherapy and of indication of surgical treatment for pulmonary tuberculosis based on bacteriological findings obtained from resected specimens (author's transl)].		1978	99593
virulence of mycobacterium tuberculosis and susceptibility to peroxidative killing systems.	at sub-bactericidal concentrations of hydrogen peroxide, mycobacterium tuberculosis was killed by hydrogen peroxide/peroxidase/halide microbicidal systems. the halide cofactor could be either iodide or, with much lower efficiency, chloride. omission of any one of the reactants eliminated the tuberculocidal effect. differences in susceptibility between different strains of m. tuberculosis did not correlate with virulence differences. the observations are discussed in the context of host defence m ...	1978	99484
the suppression of the appearance of bacterial mutants by combined antibacterial therapy.		1978	99422
depression of protective mechanisms against microörganisms in tumor-bearing mice and its restoration by adjuvants.	bacterial growth within 72 hr after an intravenous inoculation with listeria monocytogenes was enhanced strikingly in the liver of mice, when viable cells of sarcoma-180 were injected subcutaneously into ddn, c3h/he, and balb/c mice 5 hr before the inoculation. such an enhanced bacterial growth appears to be attributable to a depressed ability of macrophages to digest engulfed bacteria. pretreatments with zymosan, killed bcg, or viable bcg prevented such depression in tumor-bearing mice and incr ...	1977	99344
[the effects of antituberculous chemotherapy in vitro under various conditions inadequate for the growth of tubercle bacilli (author's transl)].		1978	99201
[studies on the antituberculous activities of rifampicin (rep) and the period of exposure in vitro (author's transl)].		1978	99200
delayed hypersensitivy and experimental interstitial pneumonitis.	the effects of prior sensitization with killed h37ra tubercle bacilli on the pulmonary reaction to intravenous (iv) challenge with complete freund's adjuvant (cfa) have been studied and were compared to reactions in nonsensitized cfa-challenged controls. rabbits that died within 24 hours of challenge demonstrated acute arteritis prior to granuloma formation. sensitized rabbits had a greater number of exudative cells in the pulmonary lavage fluid and a larger volume of parenchymal infiltrate than ...	1978	99116
[antitumor activity of the bacterial walls of br. abortus 99].	a brief chronologic survey is made of investigations that reveal that the bacterial cell walls and their chemical components exhibit antitumoral activity. discussed is the problem which are the constituents of the bacterial wal and what is the mechanism through which such effects are produced. the conclusion is drawn that some peptides participating in the structure of the bacterial wall after their release in body stimulate the macrophages and thus confer antitumoral activity to them.	1978	98899
differentiation of bcg from other variants of mycobacterium tuberculosis isolated from clinical material.	bcg isolated from clinical material may be reliably differentiated from other variants within the species mycobacterium tuberculosis by means of a few simple cultural and biochemical tests and by bacteriophage typing. animal pathogenicity tests may therefore be avoided.	1978	98878
[tuberculosis infection].		1978	98846
the conversion of sputum in tuberculosis.		1978	98840
frequency and epidemiology of primary drug-resistance in tuberculosis in the federal republic of germany including berlin (west). partial result of a study of the w.a.t.l.		1978	98839
experimental data on the antimicrobial activity of isoprodian (pth).		1978	98838
differentiation of mycobacteria by "in vivo" and "in vitro" delayed hypersensitivity reactions.	guinea pigs were sensitized with heat killed m. tuberculosis, m. kansasii, m. scrofulaceum, and m. avium-intracellulare. purified protein derivatives (ppds) prepared from each of these organisms were tested for delayed type hypersensitivity by lymphocyte transformation, macrophage migration, and mantoux type skin sensitivity tests. the homologous reactions were consistently more intense than heterologous reactions in all three procedures. the skin test procedure was more sensitive than either in ...	1978	98814
[a new therapeutic approach to open pulmonary tuberculosis with a combination of isoniazid, prothionamid and dapson (author's transl)].		1978	98759
drug-resistant tuberculosis.		1978	98637
host-parasite relationships in experimental airborne tuberculosis. vii. fate of mycobacterium tuberculosis in primary lung lesions and in primary lesion-free lung tissue infected as a result of bacillemia.	evidence suggests that in humans tuberculous disease usually arises at apical or subapical sites in the lungs seeded as a consequence of an early bacillemic phase of the infection. this study examined the fate of bacilli transported via the bloodstream to metastatic sites in the lungs of guinea pigs after aerosol infection with approximately two viable virulent mycobacterium tuberculosis. the results revealed that, even after logarithmic-phase multiplication of bacilli in primary lesions had bee ...	1978	98601
bacteria induce lymphokine synthesis polyclonally in human b lymphocytes.	we have studied the ability of various bacteria to stimulate human lymphocytes to produce leukocyte migration inhibitory factor (lif). mononuclear cells from adult and cord blood as well as purified t and b lymphocytes were stimulated with killed bacteria. the culture supernatants were tested for the presence of lif by the agarose migration method. all nine bacterial strains tested activated unseparated mononuclear cells and b lymphocytes but not t cells to produce lif. lif was also present in c ...	1978	98583
manipulations of the phagosome-lysosome fusion response in cultured macrophages. enhancement of fusion by chloroquine and other amines.		1978	98333
identification and drug sensitivity of tubercle bacilli from addis ababa, ethiopia.		1978	98117
enhancing effect of passive immunization with mycobacterial antibodies on humoral and cellular immunity in bcg-infected mice.	the present paper is an attempt to get insight about the mechanisms involved in the enhancing phenomenon that occurs in bacterial infections. mice infected with small doses of the bcg strain of m. bovis and treated with a m. tuberculosis h37rv antiserum investigated at various intervals for their capacity to synthesize haemagglutinating antimyco-bacterial antibodies and to develop delayed hypersensitivity to ppd. as controls, bcg-infected mice were treated with the antiserum freed from its mycob ...	1978	98097
niacin-negative strain of mycobacterium tuberculosis.		1978	98083
effect of low temperature on growth, viability, and synthesis of mycolic acids of mycobacterium tuberculosis strain h37ra.	cultures of mycobacterium tuberculosis strain h37ra were grownto early logarithmic phase at 37 degrees c and were incubated at 16 degrees, 20 degrees, and 25 degrees c. the decrease in this ability was more rapid at 20 degrees c than at 16 degrees c. low-temperature incubation caused decreases in the ratios of mycolic acids and monounsaturated c16-19 fatty acids relative to the total of fatty acids synthesized. it also caused an increase in the ratio of saturated c24-26 fatty acids relative to ...	1978	98081
[character of bacillus elimination in patients with freshly detected pulmonary tuberculosis].		1978	97865
mycobacteriosis in monkeys: a report of two cases.		1978	97835
[tuberculosis and mycobacteriosis in cattle in the province of santander].		1977	97771
[derivatives of 2-thion-3-isonicotinoylamino-thiazolid-4-one with tuberculostatic activity].		1978	97745
antimycobacterial antibodies in tuberculosis. i. the counterimmunoelectrophoresis (cie) test.		1978	97743
[quantitative method of assessing the virulence of mycobacterium tuberculosis in an experiment on guinea pigs].		1978	97664
[virulence of h37rv cultures treated with mycobacteriophages].		1978	97663
[virulence of rifampicin-resistent mycobacterium tuberculosis].		1978	97662
[action of streptomycin-group preparations on experimental tuberculosis caused by sensitive and resistent mycobacterium tuberculosis].		1978	97661
[method of rapid determination of the cord factor in the mycobacterium colonies on solid nutrient medium].		1978	97660
[method of increasing the effectiveness of the passive phosphatide hemagglutination test].		1978	97659
[chemotherapy of tuberculosis with controlled viability of mycobacteria in the sputum].		1978	97658
[study of specific sensitivity of the erythrocytes in pulmonary tuberculosis].		1978	97657
cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis.	rats of the lewis strain were fed diets adequate or deficient in essential fatty acids (efa). at 70-80 days of age experimental allergic encephalomyelitis (eae) was induced using adjuvants containing either mycobacterium butyricum or mycobacterium tuberculois h37ra. when the former mycobacterium was used, the incidence of eae was greater in the efa-deficient than in efa-adequate controls; but when the rats challenged with m. tuberculosis, the incidence of the disease was the same in both dietary ...	1978	97486
nitrate reductase activity of mycobacterium tuberculosis and mycobacterium bovis in the presence of electron donors.	the activities of the nitrate reductase enzyme of mycobacterium tuberculosis, m. bovis, and of bcg were assayed with and without addition of electron donors. m. tuberculosis always reduced nitrate; m. bovis did so only in the presence of electron donors, and bcg did not show enzymatic activity.	1978	97306
mycolic acids. a reinvestigation.	mycolic acids derived from the cell walls of mycobacterium bovis bcg, mycobacterium bovis bovinus i, mycobacterium smegmatis, and mycobacterium tuberculosis h37rv have been fractionated as their p-bromophenacyl esters by a two-step high performance liquid chromatographic procedure: 1) adsorption chromatography on 10-micrometer particle size silica gel, and 2) reverse phase partition chromatography on a 10-micrometer particle size support containing a c18 bonded phase. this procedure has resulted ...	1978	97301
characterization of the purified components of a new homologous series of alpha-mycolic acids from mycobacterium tuberculosis h37ra.	homologous series of alpha-mycolic acids from mycobacterium tuberculosis h37ra were separated according to size as their p-bromophenacyl ester by bonded c18 reverse-phase, high performance liquid chromatography. mass spectrometry of the prominent components separated by high performance liquid chromatography gave relatively simple spectra and showed a series of components differing by 28 atomic mass units. a total of different structures were identified. the structures were established as follow ...	1978	97292
activity of amikacin against mycobacterium tuberculosis.		1978	97261
evaluation of diagnostic criteria in tuberculous meningitis in children, including the hemagglutination test on the cerebrospinal fluid.		1977	97215
lipids of the streptomycettes. structural investigation and biological interrelation a review.	during a systematic investigation of lipids of streptomycetes a series of compounds of biochemical and microbiological interest have been isolated and characterized. these include several menaquinones, glycosyl diglycerides (glucuronosyl and isoladobinosym diglycerides), two ornithino lipids and a diol phospholipid. some of these lipids were not known previously as constituents of streptomycete cells although they have been encountered elsewhere; others have proved to be novel lipids. the result ...	1978	96946
test for differentiation of m. tuberculosis and m. bovis from other mycobacteria.	a test is described for selective inhibition of mycobacterium tuberculosis and m. bovis isolates in fluid medium. the method employs rho-nitro-alpha-acetyl-amino-beta-hydroxy-propiophenone (nap) as an inhibitory agent for differentiation of mammalian tuberculosis strains from other mycobacteria.	1978	96930
studies on transfer rna from mycobacteria.	active preparations of trna and aminoacyl-trna synthetases have been isolated from exponentially growing cells of mycobacterium smegmatis and mycobacterium tuberculosis h37rv. though the aminoacyl-trna synthetases of older cells retain their activity, the trnas seem to undergo modification and show poorer activity. the mycobacterial enzyme preparations catalyse homologous and heterologous aminoacylation between trna from the two species (m. smegmatis and m. tuberculosis h37rv) or from escherichi ...	1978	96929
biological nitrogen fixation in the terrestrial environment of a high arctic ecosystem (truelove lowland, devon island, n.w.t.).	arranged in descending order of nitrogen-fixing (acetylene-reducing) potential the sites examined were mesic meadow and peat polygon troughs (equal rank), transition zone between mesic meadow and gravel ridge, gravel ridge, polar dessert, and peat polygon tops. the dominant nitrogen-fixing microorganisms, as in other arctic areas, were blue-green bacteria, especially those epiphytic on arctic mosses. the epiphytic association exhibited an optimum temperature for fixation of 20 degrees c. other b ...	1978	96927
a new experimental model of systemic connective tissue disease in immunized rabbit.	in rabbit, the immumizations with whole mycobacterium tuberculosis injected intradermally and its crude cytoplasmic w.s.e. injected intraarticulary induce not only a self-perpetuating synovitis in the stimulated knee but also chronic systemic lesions of connective tissue (non-stimulated knee, both shoulders, aortic artery adventitial valvular endocardium, liver, kidneys and lungs). w.s.e. stimulates precipitating antibody synthesis, skin reaction and lymphoblastic transformation of lymphocytes i ...	1978	96883
tryptophan uptake by mycobacterium tuberculosis h37rv: effect of rifampin and ethambutol.	uptake of radioactive tryptophan by mycobacterium tuberculosis h(37)rv grown in vitro and in vivo was investigated. k(m) values indicated low affinity, and sodium azide inhibited uptake. rifampin at the minimal inhibitory concentration had no effect, whereas ethambutol inhibited uptake only in the bacilli grown under in vitro conditions. the significance of these results is discussed.	1978	96733
antigenic relationships of various mycobacterial species with mycobacterium tuberculosis.	antigen cross reactivity of various mycobacterial sonicates with mycobacterium tuberculosis was studied by fused rocket immunoelectrophoresis using 2 mycobacterium tuberculosis reference antisera. a considerable degree of cross reactivity was noted with both antisera, and each anti-serum revealed different information about the antigenic complexities between mycobacteria.	1978	96711
[studies of pyrazine derivatives. vi. synthesis and tuberculostatic activity of 6-alkoxy and 6-phenoxy pyrazine-2-carbothioamides].		1978	96662
detection of antibodies to mycobacterium johnei by counterimmunoelectrophoresis.	counterimmunoelectrophoresis (cie) was applied in the detection of antibodies to mycobacterium johnei in 110 sheep, 11 goat and 31 cattle sera and compared to immunodiffusion (id) test. one per cent noble agar, 7 ml per slide of 5 cm x 10 cm; barbitone-tris buffer, mu = 0.03, ph 8.6; a constant current of 5 ma per slide and m johnei protoplasmic antigen at 4 mg per ml were found to impart high sensitivity to cie and give rapid results. cie detected 97 sheep, 11 goat and 31 cattle positive sera, ...	1978	96579