Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| evidence for an infectious etiology of rheumatoid arthritis. | 1975 | 808992 | |
| [effect of immunostimulation by corynebacterium parvum on evolution and metastatic dissemination of lewis's tumor in mouse c57bl/6 mice]. | treatment with corynebacterium parvum (c. parvum) produces a significant prolongation of survival time of lewis tumor bearing animals and reduces strikingly the incidence of pulmonary metastasis in syngeneic c57bl/6 mice. on the other hand, treatment with imuran, a known immunodepressive agent, reduces survival time and facilitates metastatic dissemination in the same model. | 1975 | 809167 |
| scabies and other skin diseases in pre-school children in ujamaa villages in tanzania. | a survey of skin diseases was carried out in pre-school children in five ujamaa villages in rufiji district and 532 children (5.3% of the total population) were screened. the results showed that scabies was the commonest skin problem affecting 31% of the children. primary pyoderma and fungal infections were relatively less common and accounted for 7.0 and 2.4% respectively. staphylococcus aureus, group a beta haemolytic streptococci and corynebacterium diphteriae were the commonest pathogeneic b ... | 1975 | 810929 |
| bacterial skin infections in preschool and school children in coastal tanzania. | in coastal tanzania, 1,855 preschool and school children were studied for pyoderma (superficial bacterial infections of the skin exclusive of secondarily infected scabies) and for scabies. the predisposing personal, socleoeconomic, and hygienic variables for both conditions were studied also. pyoderma lesions and some secondarily infected scabies were cultured aerobically for bacterial isolates and the predisposing factors were determined by interviews, home visits, and physical examinations. py ... | 1975 | 811175 |
| dichotomy between macrophage activation and degree of protection against listeria monocytogenes and toxoplasma gondii in mice stimulated with corynebacterium parvum. | in vivo and in vitro experiments were conducted to determine the effect of corynebacterium parvum treatment of mice on resistance of listeria monocytogenes and toxoplasma gondii. intravenous immunization with c. parvum conferred transient protection against intravenous challenge with listeria or an avirulent strain of toxoplasma but did not protect against a virulent strain of toxoplasma. compared with the level of protection conferred by c. parvum, a higher degree of resistance was noted when m ... | 1975 | 811563 |
| selective adhesion of microorganisms to the ductular epithelium of the bovine mammary gland. | streptococcus agalactiae, streptococcus faecalis, staphylococcus aureus, escherichia coli, and corynebacterium bovis were examined for their ability to adhere to the ductular epithelial cells of the bovine udder. s. agalactiae and s. aureus adhered readily and in large numbers, whereas the other organisms adhered poorly or not at all. the organisms showing the ability to adhere are those which frequently cause mastitis. these data suggest that selective adherence to the ductular epithelium may b ... | 1975 | 811566 |
| enhancement of resistance and suppression of immunization against experimental trypanosoma cruzi infection by corynebacterium parvum. | intravenous but not intraperitoneal injection of killed corynebacterium parvum either before or after intraperitoneal infection with the highly reticulotropic tulahuén strain of trypanosoma cruzi produced enhanced resistance against the infection in mice. in contrast, c. parvum had no effect when the infection was caused with the predominately myotropic y strain of t. cruzi. c. parvum given intravenously before immunization with killed culture forms of the y strain parasite consistently diminish ... | 1975 | 811568 |
| numerical analysis of the characteristics of corynebacterium diphtheriae strains isolated in victoria from 1962 to 1971. | a study of the incidence of diphtheria in the state of victoria, australia, was carried out. numerical analysis of the characteristics of 264 strains of corynebacterium diphtheriae isolated between 1962 and 1971 placed them into 18 varieties plus six strains which were unique in their combination of reactions to the characteristics examined. during the 10-year period, some varieties appeared intermittently and were recognized by certain defining characteristics but exhibited a gradual change in ... | 1975 | 811707 |
| adjuvant activity of mycobacterial fractions. iii. adjuvant effect of cell wall of mycobacterium bovis bcg on cell-mediated cytotoxicity in mice. | a quantitative assay and characterization of oil-attached cell wall of mycobacterium bovis bcg (bcg-cws) which stimulates cell-mediated immunity of spleen cells to alloantigens in mice were carried out by an in vitro cell-mediated cytotoxicity test using 51cr-labeled target cells. c57bl/6j mice (h-2b) were immunized intraperitoneally with mastocytoma cells (h-2d) with or without oil-attached bcg-cws. the cytotoxicity, comparable to that of spleen cells from mice immunized with mastocytoma cells ... | 1975 | 811834 |
| chemical and immunological studies on the cell walls of propionibacterium acnes strain c7 and corynebacterium parvum atcc 11829. | the chemical and immunological properties of the cell walls prepared from the cells of anaerobic coryneforms, propionibacterium acnes c7 and corynebacterium parvum atcc 11829, were partially investigated. the cell walls prepared from p. acnes c7 and c. parvum atcc 11829 were composed of fatty acids, polysaccharides consisting glucose, galactose and mannose and mucopeptides consisting mainly of alanine, glutamic acid, alpha, epsilon-diaminopimelic acid, glycine, muramic acid and glucosamine. as t ... | 1975 | 811835 |
| ecological studies of the microbial flora of the female lower genital tract. | 1975 | 812101 | |
| [pathogenetic aspects of the "healthy" diphtheria bacteria carrier state]. | 1975 | 812302 | |
| [patterns of antimicrobial immunity in carriers of toxigenic diphtheria bacteria]. | it was shown in the passive hemagglutination test (phat) with a type-specific somatic antigen on 147 carriers of toxigenic diphtheria bacilli that the phat titres of 1/80 and over were determined in 64% of bacteria. in the process of carrier state of toxigenic bacteria antimicrobial antibodies were detected in 79% of the children; after the release from the carrier state, the percentage was from 57 to 26, depending on the time lapse after it. among the carriers of nontoxigenic diphtheria bacilli ... | 1975 | 812306 |
| [study of the reasons for a decrease in the inoculability of diphtheria bacteria]. | it was shown that the seeding efficacy of diphtheria bacilli depended not only on the state of the epidemic process, but also on the correct methodical approach to the examination. a combination of the qualitative and epidemiological choice of the groups of population for bacteriological examination with the use of blood tellurite media permitted to increase the efficacy of investigations, with a considerable reduction of the number of analyses. | 1975 | 812307 |
| [enzymatic properties of neuraminidase from corynebacterium diptherial]. | enzymatic properties of neuraminidase isolated from non-toxigenic strain c7 of diphteritic bacteria are studied. the enzyme has the ph optimum 5.5--6.0 in acetate buffer and the temperature optimum 38 degrees c. neuraminidase has the highest substrate affinity to glycoproteins of equine blood serum, the lowest affinity--to 3-n-acetylneuraminosyllactose and ovomucin. the km values was 4.3-10(-4) at optimal conditions under the hydrolysis of 3-n-acetylneuraminosyllactose, vm was 0.05+/-0.02 mum na ... | 1975 | 812557 |
| [etiology of dairy cows mastitis in slovakia in the years 1972-1974]. | in the period from 1972 to 1974, veterinary institutes in slovakia performed bacteriological examinations in 178,853 milk samples coming from 72,454 dairy cows. on an annual average, the number of examined samples were higher by 61% than in 1967-1971. germs responsible for the inflammation of the mammary gland were found in the milk of 22.32% of the dairy cows. the following bacterial germs were represented: streptococcus agalactiae -- 15.77%, staphylococcus aureus -- 4.19%, other streptococci ... | 1975 | 813355 |
| [antibacterial activity of a lysozyme-like enzyme from staphylococci]. | a lysozyme-like enzyme isolated from the culture broth of staph. aureus 712 presented in its native state a lipoproteid complex. the lytic and antibacterial spectrum of the enzyme was similar to that of the egg albumin enzyme. however, the lipoproteid complex was somewhat superior to the egg albumin complex in its activity against micrococcus lysodeikticus, a number of gramnegative bacteria and staphylococci. out of the organisms studied microccus lysodeikticus, sarcina and bac. subtilis proved ... | 1975 | 813563 |
| effects of three environmental variables on sulfate uptake by aerobic bacteria. | the effects of various concentrations of sulfate, organic sulfur, and organic carbon on sulfate uptake by aerobic bacteria were studied using pure cultures growing in a defined medium. cultures of pseudomonas fluorescens and corynebacterium striatum took up sulfate faster when young, but sulfate uptake by serratia marcescens was faster in older cultures. organic sulfur was found to decrease sulfate uptake, but at concentrations somewhat higher than occurs in most natural freshwater ecosystems. l ... | 1975 | 813579 |
| the effect of gold salts on tumour immunity and its stimulation by corynebacterium parvum. | the anti-inflammatory agent sodium aurothiomalate appears to act upon mononuclear phagocytes, inhibiting their lysosomal enzyme activity. evidence is presented that gold salts can increase the number of lung tumour nodules that develop following intravenous injection of tumour cells and pretreatment can enhance the take of a subcutaneous tumour inoculum. in contrast, they do not affect the later growth of tumour. gold salts can also suppress the action of systemically administered c. parvum in i ... | 1975 | 813755 |
| [etiology of mastitis in dairy cows in slovakia during 1972-1974]. | in the period from 1972 to 1974, veterinary institutes in slovakia performed bacteriological examinations in 178,853 milk samples coming from 72,454 dairy cows. on an annual average, the number of examined samples was higher by 61% than in 1967-1971. germs responsible for the inflammation of the mammary gland were found in the milk of 22.32% of the dairy cows. the following bacterial germs were represented: streptococcus agalactiae - 15.77%, staphylococcus aureus - 4.19%, other streptococci - 1. ... | 1975 | 814671 |
| [use of the corycin test and of bacteriophage typing for genetic marking of corynebacteria with reference to c. diphtheriae of the gravis type]. | nontoxigenic c. diphtheria, fermenting starch, of convertible phage types abcdfch, abcdfg, abcdf, abcd, abd, acdf, cdf, af and a, and also strains of nonconvertible bacteriophage types i, h and k proved to be noncoricynogenic in the corycine test and weakly sensitive to bacteriocin of the no. 3463 test strain (a study was made of a total of 502 strains). strains (383) isolated from 354 patients and carriers--starch-fermenting and toxigenic to the gravis type--were toxigenic were lysed by a combi ... | 1975 | 814754 |
| [the effect of neuraminidase of c. diphtheriae on the functional capacity of the peritoneal exudate cells of guinea pigs to diphtheria bacilli]. | a study was made of the effect of neuraminidase preparation containing no diphtheria toxin admixtures and hyaluronidase on the phagocytic activity of macrophages. neuraminidase produced a stimulating effect on the cells of the developing macrophage culture. the macrophages treated with the enzyme increased their capacity to digestion of nontoxigenic diphtheria bacilli. | 1975 | 814758 |
| failure of corynebacterium parvum presensitization to modify the antitumor effects of systemic and local therapeutic injections of c. parvum in mice. | the therapeutic effects of iv and intralesional injection of corynebacterium parvum against mastocytoma p815 in mice, presentized and showing marked delayed hypersensitivity to c. parvum, were no different from those in unimmunized controls. | 1976 | 815560 |
| isolation and partial characterization of a corynebacteriophage beta, tox operator constitutive-like mutant lysogen of corynebacterium diphtheriae. | we have isolated and partially characterized a beta-phage mutant lysogen of corynebacterium diphtheriae, c7(betatoxct1+), which is partially insensitive to iron inhibition of diphtheria toxin production. tox expression by c7(betatoxct1+) was found to be partially constitutive. in the presence of concentrations of iron that almost completely inhibit the expression of diphtheria toxin by the wild type, c7(beta), the level of toxin production by c7(betatoxct1+) was found to be at least 25 times tha ... | 1976 | 815566 |
| [the antibacterial effect of organs and tissues of hyalomma dromedarii, hyalomma anatolicum and ixodes persulcatus ticks]. | 1975 | 815775 | |
| studies on diphtheria in bombay. | 1975 | 815957 | |
| iron and diphtheria toxin production. | 1975 | 815958 | |
| activity of four cephalosporin antibiotics in vitro against bovine udder pathogens and pathogenic bacteria isolated from newborn calves. | the in vitro activity of chephaloridine, cephalexin, cefatrizine (bl-s640), and cephapirin (bl-p-1322) was evaluated by the serial dilution method against pathogenic gram-positive and gram-negative bacteria isolated from bovine udders and neonatal calf diseases. cephapirin showed the comparatively greatest activity against the most common streptococcal species associated with bovine mastitis, whereas cephaloridine exhibited the best activity against staphylococcus aureus. cefatrizine was more ac ... | 1976 | 816249 |
| level of redox potential as a possible contributing influence in the pathogenicity of oral anaerobes. | dental plaque anaerobes may be associated with the etiology of periodontal disease. this has created an interest in the potential pathogenicity of oral anaerobes. we compared the metabolic activity of anaerobic corynebacteria (c. parvum, c. anaerobium) and corresponding aerobic species (c. diphtheriae, c. xerosis). the anaerobes exhibited lower levels of rna synthesis, ranging from 5 to 10 fold over the aerobes. we further examined these anaerobes, plus actinomyces naeslundi n16 (isolated from t ... | 1975 | 816253 |
| [effect of corynebacterium parvum on murine cultured bone marrow cells]. | the administration of corynebacterium parvum (c. parvum) stimulates in the mouse the bone marrow colony forming cell compartment in two stages. the first stage reaches pic values one day after two consecutive injections and the second, more important stage, reaches a pic at the 9th day which lasts over 27 days. there is no evidence that this effect is related to the liberation of csf. | 1976 | 816561 |
| [treatment of experimental brucellosis of mice and guinea pigs by rifampicin]. | the intracellular and bactericidal activity of rifampicine was observed in the treatment of experimental brucellosis in the mouse and guinea pig. batches of mice infected by intraperitoneal route with b. melitensis, strain 53 h 38, were treated with rifampicine (20 mg/kg/day) or with tetracycline-base (200 mg/kg/day). when the treatment begins 14 days after inoculation and lasts a week, the rifampicine produces a more significant decrease of the weight of the spleen than does tetracycline. after ... | 1976 | 816684 |
| effect of cytochalasin b on the adhesion of mouse peritoneal macrophages. | the adhesion of normal mouse macrophages to glass surfaces was reduced by nontoxic levels (1-50 mug/ml) of cytochalasin b in combination with a centrifugal force (1,000-8,000 g). macrophages nonspecifically activated by corynebacterium acnes were also detached by this treatment, but less effectively. the effects of cytochalasin b treatment on these cells were shown to be reversible. after detachment, the cells reattached to glass, appeared morphologically normal, and behaved like untreated cells ... | 1976 | 816801 |
| studies on diphtheria infection in and around delhi (a bacteriological study from faucial and cutaneous lesions). | 1975 | 816969 | |
| [microbiological characteristics and sensitivity to antibiotics of decamethoxin-resistant diphtheric bacilli]. | biological properties and sensitivity of 6 corynebacteria strains to 9 antibiotics were studied in vitro. the rate of the development of resistance to neomycin, levomycetin, decamine and decamethoxin in the diphtheria causative agents was determined. biological properties of the decamethoxin resistant variants of the diphtheria causative agents were investigated: 100 passages on media with increasing amounts of the drug. the rate of the development of resistance to decamethoxin was slower than t ... | 1975 | 817649 |
| mitogenicity of corynebacterium parvum for mouse lymphocytes. | corynebacterium parvum, a powerful in vivo immunostimulant, is shown to stimulate lymphocyte proliferation in vitro. c. parvum is mitogenic for b lymphocytes and does not stimulate t cells. the mitogenicity is dependent on the presence of macrophages. c. diphtheriae and another strain of c. parvum, both of which are devoid of adjuvant, res stimulation, and tumour-inhibiting activities in vivo are nevertheless mitogenic. a lipid-free fraction from c. parvum, which retains in vivo immunostimulator ... | 1975 | 817854 |
| antimicrobial activity of econazole and miconazole in vitro and in experimental candidiasis and aspergillosis. | the antibacterial and antimycotic activity of econazole base, an imidazole derivative, was examined in vitro and in experimental infections of mice. comparative minimal inhibitory concentration (mic) determinations indicate econazole as well as miconazole to be of moderate activity against gram-positive bacteria (mics: 0.78-25mug/ml) and yeasts (mics: 1.56-25 mug/ml). against filamentous fungi, econazole exhibits better in vitro activity than miconazole and - with the exception of rhizopus oryza ... | 1976 | 817875 |
| ]acute severe mastitis in cows of the dutch-friesian breed (author's transl)]. | one hundred cases of severe acute mastitis are reported. bacteriological examination of the milk was negative in 23% of the cases. e. coli was most frequently found to be the causative organism (23%), followed by st. aureus (19%), c. pyogenes (10%), str. dysgalactiae (9%), str. agalactiae (5%) and a number of other pathogenic agents such as atypical streptococci, str. uberis, haemolytic streptococci, aerobacter aerogenes, kl. pneumoniae, a clostridium and p. multocida. in several cases, a tentat ... | 1976 | 818734 |
| [bacterial flora and preventive antibiotic treatment in open fractures]. | in 172 patients with open fractures of long tubular bones the wound bacterial flora was studied on their admission to the clinic and in occurrence of suppurative complications. there were no cases of "outdoor" microorganisms being the cause of suppuration. pathogenic agents of suppurative infection differed from "outdoor" strains in their species content, signs of pathogenicity, sensitivity to antibiotics. as a rule, suppuration was preceded by soft tissues necrosis. since wound suppuration was ... | 1975 | 818772 |
| proceedings: taxonomy of aerobic cutaneous diphtheroids. | 1976 | 819023 | |
| [new fluorescent microscopical technique in diagnostic microbiology (author's transl)]. | the practicability of 4',6-diamidino-2-phenylindole (dapi) in the fluorescent microscopical demonstration of bacterial and other cellular structures for medical diagnostic purposes was investigated. polar bodies in diphtheria bacilli and spores of spore-forming bacteria showed up well. the demonstration of phagocytosed bacteria in urinary sediment and the morphology of human spermatozoa are particularly impressive. noteworthy advantages of dapi are its stability (no bleaching of stained preparat ... | 1976 | 819241 |
| quantitation of neisseria gonorrhoeae from women with gonorrhea. | the number of infecting organisms has been shown to be an important variable in animal models of infection with neisseria gonorrhoeae. this variable may also be important in the natural transmission of gonorrhea in humans. the number of gonococci in the cervicovaginal area of women with gonorrhea is unknown, as are the effects of certain physiologic or therapeutic variables on the number of gonococci. in this study a semiquantitative technique for the enumeration of n. gonorrhoeae was used; 10 m ... | 1976 | 819594 |
| corynebacterium diphtheriae endocarditis. | two patients with corynebacterium diphtheriae endocarditis have been observed in the past ten years. both cases occurred sporadically. in one case toxigenic c. diphtheriae caused endocarditis in an immunized child with congenital heart disease. the second patient developed rapidly progressive valve destruction caused by a nontoxigenic strain of c. diphtheriae. these cases illustrate that c. diphtheriae may produce endocarditis in addition to its previously described diseases spectrum. | 1976 | 820199 |
| comparison of coarse mesh gauze with biologic dressings on granulating wounds. | twenty patients with large area granulating wounds were selected for the study. on each patient, a small area of uniform appearance was divided into four subareas, and each subarea was randomly assigned treatment with a single 24 hour application of cadaver allograft, fresh porcine xenograft, formalinized xenograft, or "wet-to-dry" applications of coarse mesh gauze changed three times daily. at 24 hours, all four areas were uncovered. the subareas were ranked in terms of appearance on a best, se ... | 1976 | 820214 |
| [studies on the frequency of corynebacterium diphtheriae carriers among students of the elementary schools in bari]. | the morbidity of diphtheria reported in bari in 1970 and in 1971 was 17.1 and 19.1 for 100000 inhabitants; in the same years the national average was respectively 1.6 and 1.3. in a epidemiological research carried out in the same period in 1017 school-children of bari not previously selected, 45 carriers of c. diphtheriae (4.42%) were identified. toxigen strains were isolated from 11 carriers (1.08%). the frequency of carriers was higher in the school-children 9-11 years aged (6-04%), lower in t ... | 1975 | 820281 |
| [studies on the diffusion of corynebacterium diphtheriae carriers in a children's community]. | during an epidemiological inquiry in a infantile community it was founded the 22.8% of 83 children was carrier of toxigen c. diphtheriae and two adults on 15 were carriers of non toxigen c. diphtheriae. the isolated species respectively from children and adults were of different phagic type. | 1975 | 820282 |
| characterization and genetic mapping of nontoxinogenic (tox) mutants of corynebacteriophage beta. | seven new nontoxinogenic (tox) mutants of corynebacteriophage beta were isolated. strains of cornyebacterium diphtheriae c 7 lysogenic for these tox mutants of beta were tested for their ability to produce extracellular diphtherial toxin or proteins (crms) that cross-react immunologically with toxin. by using a sensitive reversed passive hemagglutination assay for toxin antigen, three of the tox mutants were phenotypically crm+ and four were crm-. the molecular weights of the crms produced by mu ... | 1976 | 820871 |
| prophage map of converting corynebacteriophage beta. | a prophage map for corynebacteriophage beta consisting of seven markers has been constructed and compared with the vegetative map. the mapping system utilizes heteroimmune double lysogens and capitalizes on the fact that these double lysogens are very unstable and throw off monolysogenic segregants. the prophage map, produced by characterizing the recombinant phage in these monolysogenic segregants, appears to be a cyclic permutation of the vegetative map with the gene for toxin at one end of th ... | 1976 | 820872 |
| isolation and characterization of tox mutants of corynebacteriophage beta. | seventeen nontoxinogenic (tox) mutants of corynebacteriophage beta have been isolated by using a tissue culture screening technique. the mutants fall into four major classes. two of the classes, i and ii, appear to contain missense and nonsense mutants, respectively. however, classes iii and iv have not been previously described. class iii mutants produce two proteins (crms) seriologically related to diphtheria toxin, but efforts to demonstrate the presence of more than one tox gene have been su ... | 1976 | 820873 |
| orientation of the tox gene in the prophage of corynebacteriophage beta. | the orientation of the gene for diphtheria toxin, tox, in the prophage of converting corynebacteriophage beta has been determined. the orientation of tox in prophage and that reported simultaneously by holmes (1976) for vegetative phage are compatible with the hypothesis that beta phage is inserted into the chromosome of its bacterial host by means of a mechanism similar to that described for lambda phage, and that the phage attachment site lies between the tox and imm genes. the position of thr ... | 1976 | 820874 |
| stimulation of the non-specific resistance by corynebacterium parvum and bacillus calmette guérin. | the effect of pretreatment of intravenously administered killed corynebacterium parvum (cp) and living bcg was studied in various model systems. both vaccines caused an increased resistance to listeria monocytogenes, indicating macrophage activation. only cp exerted a suppressive effect on t-cell-mediated immunological phenomena (skin allograft survival; antibody production to tetanus toxoid; expulsion of adult t. spiralis worms from intestine). results of experiments with congenitally athymic ( ... | 1976 | 821172 |
| [new concept of the taxonomic position of anaerobic corynebacteria]. | the new phenotypic and genotypic characteristics of the anaerobic coryneforms allow us to individualize them in a new sub-genus: coryneformis nv. sub-gen so defined: corynebacteriaceae with morphology of true corynebacterium from which they differ by pathogenicity, the ability to synthesize reticulo-stimulin, their cell-wall composition, thier g + c%, their anaerobic growth and their salmon-pink colonies. they differ also from the true propionibacterium which are not pathogenic, do not synthesiz ... | 1976 | 821638 |
| the aerobic flora of the perivaginal area: its relation to contraception and deodorant sprays. | 1976 | 821908 | |
| nonspecific resistance against trypanosoma cruzi enhanced by corynebacterium parvum. | 1976 | 822147 | |
| diphtheroid endocarditis. report of nine cases and review of the literature. | diphtheroid endocarditis is a rare disease. a large proportion of the reported cases have occurred in the presence of prosthetic heart valves. nine previously unreported cases of diphtheroid endocarditis are discussed along with 25 others taken from the literature. eight out of the nine new cases occurred in patients with artificial heart valves. a high mortality was associated with infections occurring on prosthetic heart valves. microbiological studies were frequently hampered by poor in vitro ... | 1976 | 822234 |
| aluminum chloride in the treatment of symptomatic athelete's foot. | various aluminum salts were evaluated for in vitro and in vivo antimicrobial activity and ability to bind with serum proteins (astrigency) with the object of finding a colorless substance to substitute for carbol-fuchsin solution (castellani paint) in the treatment of symptomatic interdigital athlete's foot. aluminum chlorohydrate was more powerful in killing bacteria and fungi than aluminum acetate and aluminum chloride. however, aluminum chloride showed pronounced astringency and was the only ... | 1975 | 822782 |
| synthesis of schiff bases of benzofuran with potential biological activity. | reduction of 5-methoxy-6-formyl(ia)- and 5-formyl-6-methoxy-2,3-diphenylbenzofuran (iva) yielded 6- and 5-methyl derivatives ib and ivb, respectively. oxidation, hydrolysis and demethylation of ib and ivb gave 2,2-dihydroxy-4-methyl-)iic)-and2,4-dihydroxy-5-methylbenzofuran )vc). the carboxamides ie and ive were obtained from the oximes ic and ivc via the cyano derivatives id and ivd. by condensation of the aldehydes if, ivf and vii with primary amines the corresponding schiff bases (iiia--c, vi ... | 1976 | 822854 |
| [contribution to the problem of circulation of diphtheric corynebacteria in the population of bratislava. i]. | 1976 | 822919 | |
| observations on lysogeny in glutamic acid bacteria. | induced lysis occurred in a number of different strains of glutamic acid bacteria. mixed culture experiments indicated that induced cultures produce phages or bacteriocins. temperate phages were isolated from two related strains of brevibacterium divaricatum. | 1976 | 823863 |
| [contribution to the problem of circulation of diphtheric corynebacteria in the population of bratislava. ii. analysis of incidence of diphteric corynebacteria and results of the study concerning their circulation in selected collective establishments (author's transl)]. | 1976 | 824032 | |
| inhibition of growth of n. gonorrhoeae by bacterial interference. | observations made in our laboratory during the past 3 years showed that the growth of some neisseria gonorrhoeae cultures was inhibited in the presence of various bacterial contaminants of urogenital specimens. a total of 647 cultures confirmed as containing n. gonorrhoeae were examined in this study. the first part of the study was carried out on 520 n. gonorrhoeae cultures. of these 520 cultures, 110 (21.1%) showed contamination on purity plates (gc medium, antibiotic-free). when further subcu ... | 1976 | 824037 |
| mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms. | the mitogenic activity of the cell walls prepared from mycobacterium bovis bcg, nocardia rubra, corynebacterium diphtheriae pw8, and four species of propionibacterium, corynebacterium parvum atcc 11829, propionibacterium acnes c7, propionibacterium granulosum atcc 25564 and propionibacterium avidum atcc 25577, were investigated. these cell walls were active as mitogens on normal spleen cells, anti-o sera-treated spleen cells, macrophage-depleted spleen cells of c57bl/6j mice and cortisone-treate ... | 1976 | 824484 |
| [mode of action of d-amino acids on the biosynthesis of peptidoglycan (author's transl)]. | the mechanism of growth inhibition by d-amino acids was studied. d-serine at concentrations from 0.02-0.2 m was sufficient to cause partial growth inhibition in seven species of bacteria representing the four most common types of peptidoglycan. the inhibited cells displayed morphological alterations. in the nucleotide-activated peptidoglycan precursors of these cells, d-alanine residues in position 4 and/or 5 of the peptide moiety were partially or even completely replaced by d-serine. the pepti ... | 1976 | 825075 |
| [immunization by canadida albicans and non-specific immunostimulation by corynebacterium granulosum and bcg in experimental candidiasis]. | immunostimulation by corynebacterium granulosum (whole bacteria or a delipided fraction p40) or by live bcg enhanced the resistance of lethally infected mice by candida albicans. the protection is greater by association with an active specific immunization by various preparations of c. albicans. | 1976 | 825252 |
| [antagonistic effect of a fraction isolated from corynebacterium granulosum toward cyclophosphamide immunosuppression in mice]. | a fraction isolated from corynebacterium granulosum was shown to be capable of increasing significantly the antibody level in response to immunization of the mouse with sheep red blood cells. the animals stimulated with this fraction become very resistant to the effect of cyclophosphamide. in contrast, the action of the fraction in previously immuno-suppressed animals is nil or very low. | 1976 | 825323 |
| thin-layer chromatographic analysis of mycolic acid and other long-chain components in whole-organism methanolysates of coryneform and related taxa. | acid methanolysates of strains representing 58 coryneform taxa were examined for mycolic acids and other long-chain constituents by thin-layer chromatography. mycolic esters were detected in the methanolysates of true corynebacteria but not in those from plant pathogenic bacteria, corynebacterium haemolyticum, corynebacterium pyogenes or from representatives of the genera arthrobacter, cellulomonas, curtobacterium, kurthia or oerskovia. thin-layer chromatography of whole-organism methanolysates ... | 1976 | 825611 |
| interaction of tumor cells and activated macrophages in vitro: modulation by corynebacterium parvum and gold salt. | 1976 | 825644 | |
| antitumor antibodies and immunoglobulin class and subclass levels in corynebacterium parvum-treated mice. | changes in immunoglobulin class and subclass levels and the development of antitumor antibodies were assessed in normal and tumor-bearing mice challenged with corynebacterium parvum. c. parvum administration resulted in a marked increase in certain immunoglobulin levels, especially ig g2b, and in the development of antibodies reacting with syngeneic and allogeneic tumor cells. the serologic changes induced by c. parvum were dependent on the dose and route of administration; preliminary studies s ... | 1976 | 825650 |
| adjuvant activity of bacterial glycolipids. | 1976 | 825676 | |
| [inhibition of proteus sp. by nalidixic acid]. | the investigation comprised 192-positive and gram-negative strains of bacteria, including 111 proteus sp. the degree of resistance of these strains to nalidixic-acid was investigated on blood agar with 25 mug, 40 mug, and 50 mug nalidixin-acid per ml medium. none of the proteus strains were able to grow on medium with 50 mug nalidixic-acid per ml, whereas streptococcus sp., corynebacterium pyogenes, peptococcus indolicus, pseudomonas aeruginosa, and beta-toxic staphylococci all were found resist ... | 1976 | 825831 |
| specific and nonspecific antitumor immunity. iii. specific t lymphocyte-mediated cytolysis of p815 mastocytoma and sl2 lymphoma by draining lymph node cells from syngeneic tumor-bearing dba/2j mice. | tumor-specific cytolytic activity, as measured by the 51cr release assay, has been demonstrated in the draining lymph node cells from dba/2 mice bearing the syngeneic p815 mastocytoma or sl2 lymphoma. this lytic activity is mediated by cytolytic t lymphocytes (ctl), since cytotoxicity is eliminated by treatment of the effector cells with anti-thy 1.2 (theta) serum plus complement but is enhanced or unaffected by anti-thy 1.2 serum alone, antimouse immunoglobulin plus complement, normal or aggreg ... | 1976 | 826167 |
| critical review of previously reported animal studies of tumor immunotherapy with nonspecific immunostimulants. | 1976 | 826208 | |
| [maceration of the interdigital spaces and gram-negative infection of feet]. | the microbiological flora of the macerated skin of the interdigital spaces of the feet of 64 patients were compared to those of 64 other control patients who had normal toe webs. in the control group coagulase-negative staphylococci and aerobic corynebacteria ("diphtheroids") were the most common bacteria found compared to a great number of different organisms including a high percentage of potentially pathogenic bacteria and fungi that were isolated from the macerated toe webs. the clinical app ... | 1976 | 826508 |
| [surface structure of corynebacteria]. | 1976 | 827168 | |
| [comparative electron-microscopic study of 8 representatives of the genus corynebacterium grown on solid nutrient medium during the stationary phase of development]. | after 18 hours of growth on selective serum-agar medium c diphtheriae cultures with different toxicogenic activity, and also diphtheroid and hoffmann's baccillus cultures were removed, washed of the remnants of the nutrient medium and fixed under cold conditions by two combined methods (with glutaric aldehyde-osmic acid--uranyl acetate, and potassium permeanganate--uranyl acetate). the preparations were studied in ultrathin sections. it appeared that corynebacteria had during the stationary phas ... | 1976 | 827882 |
| a study of the isolation of corynebacterium diphtheria from clinical cases of diphtheria. | throat swabs from 1000 clinical cases of diphtheria were studied for isolation of c. diphtheria; only 21.4% were found to be positive. most of the cases were between 1 to 4 years of age followed by 5 to 8 years. no cases were found below 8 months of age. the throat swabs taken from another 22 clinical diphtheria patients were immediately cultured at patients bed side and 63.6% were found to be positive for c. diphtheria. time between the collection and plating the specimen was considered to be o ... | 1976 | 828854 |
| a comparative study of bacteriologically proved and clinically diagnosed (culture negative) cases of diphtheria. | 1976 | 828918 | |
| [etiology of mastitidos in dairy cows in slovakia during 1975]. | in 1975, in the veterinary institutes in slovakia bacteriological examinations of 54824 samples of milk coming from 28737 dairy cows were performed. bacterial germs responsible for the inflammation of the mammary gland were found in the milk of 18.91% of cows. these were: streptococcus agalactiae (in 13.93% of cows), staphylococcus aureus (2.86%), other streptococci (1.32%), e. coli (0.13%), klebsiella sp. (0.13%), corynebacterium pyogenes (0.15%), other bacterial germs (0.39%). streptococci and ... | 1976 | 828997 |
| [biosynthesis and function of diphtheria toxin and its related proteins (author's transl)]. | 1976 | 829169 | |
| bacterial flora of the healthy skin in children. | the normal bacterial flora of the skin of 100 healthy children was studied in a paediatric practice with regard to the germ spectrum and the resistance constellation, by means of abrasion skin samples taken from the upper part of the back. staphylococcus albus was by far the most predominant bacteria, followed by sarcina bacteria and corynebacteria. the high degree of pervasion of this physiological cutaneous flora with antibiotic-resistant strains increases the suspicion that in the case of flo ... | 1976 | 829225 |
| meatal recolonization in bitches. | colonization of the urethrovaginal area precedes urinary tract infection in women. among the potential factors limiting colonization by fecal pathogens is bacterial interference, the ability of established commensals to inhibit colonization by pathogenic bacteria. since the microcontour of the canine distal urethra possesses microvilli like those in the vagina rather than the microplicae found at higher levels and also has similarities in cellular glycogen content the meatal area would be expect ... | 1976 | 829557 |
| multiple-carbon-source-limited growth kinetics of a marine coryneform bacterium. | the steady-state growth rate of a marine isolate was related to the concentrations of several carbon and energy source substrates when these substrates limited growth simultaneously in continuous culture. glucose limitation was characterized by a threshold of 0.21 mg/liter for growth, a half-maximal growth rate at 0.48 mg/liter, u-shaped curves in extractable pool concentration-versus-growth velocity plots, and slow maximal growth rates. arginine addition reduced the glucose threshold to 0.008 m ... | 1977 | 830637 |
| quantitative microflora of the vagina. | this study enumerated the predominant vaginal flora in 25 healthy patients: 18 prenatal (six with and 12 without gonorrhea) and seven nonpregnant without gonorrhea. all 25 patients had aerobes and 19 of the 25 had anerobes isolated in titers of greater than or equal to 10(5) colony-forming units (cfu per milliliter). the most frequently isolated microorganism was the lactobacillus (aerobic and anaerobic species) followed by c. vaginale, viridans streptococci, anaerobic gram-positive cocci, and b ... | 1977 | 831488 |
| rapid and accurate measurement of growth of solid tumours and changes in the tumour bed in the rat by the technique of volumetric displacement. | an apparatus which has been widely used in rats for measuring swelling of the foot induced locally by inflammatory agents has been adapted to measure rapidly, accurately and objectively, the growth of tumour cells transplanted to the foot, and the reactions of the normal tissues (tumour bed) to tumour growth. general features on the apparatus and the techniques used are described. examples are provided of preliminary measurements made of normal growth of the foot, reactions of the foot to two i ... | 1977 | 831762 |
| mycoplasma agalactiae subsp. bovis in pneumonia and arthritis of the bovine. | the pneumonic lungs of 42 cattle from 26 feedlots were examined for the presence of mycoplasma, pathogenic bacteria and viruses. four animals representative of two lots failed to yield mycoplasma. one of these yielded the virus of infectious bovine rhinotracheitis and pasteurella hemolytica, the other yielded only p. p. multocida. nine animals in eight lots yielded mycoplasma sp.: five of these were m. bovirhinis, two were m. arginini and two were untypable. all of these animals yielded one or m ... | 1977 | 832194 |
| antibiotics and skin infections: when to use local or systemic measures. | 1977 | 832615 | |
| organ distribution of corynebacterium parvum labeled with iodine-125. | administration of iv, ip, single sc, multiple sc, and footpad injections of [125i]corynebacterium parvum in mice revealed different patterns of radioactive vaccine distribution in various organs. high deposition and retention were found in the liver, spleen, and gastrointestinal tract and less in the lungs, kidneys, thymus, and bone marrow. control animals given 125i showed very rapid clearance of the isotope and no retention in the organs. the pattern of distribution of [125i]c. parvum could be ... | 1977 | 833877 |
| [degradation of aflatoxin b1 by various microorganisms (author's transl)]. | the degradation of aflatoxin b1 by various representatives of bacteria, yeasts and moulds in growing and resting cultures was investigated. we found that growing cultures of corynebacterium rubrum degraded the added aflatoxin nearly quantitatively. -- growing cultures of anascosporogenous yeasts degraded most of aflatoxin b1 while no degradation of this substance by ascosporogenous yeasts could be stated. moulds degraded aflatoxin b1 to a high extent. -- with regard to the course of degradation ... | 1977 | 835342 |
| systemic therapy for metastatic breast cancer. | the data reviewed in this conference suggest that initial therapeutic decisions for patients with metastic breast cancer be based on the presence or absence of an estrogen receptor in the tumor. patients with estrogen receptor in their original primary breast cancer or in a subsequent metastitic lesion are candidates for hormonal manipulation, whereas patients lacking estrogen receptor in their tumor are treated for their metastic disease with nonhormonal chemotherapy. nonhormonal therapy usuall ... | 1977 | 835932 |
| corynebacterium haemolyticum as human pathogen. | 1977 | 835952 | |
| intravenous corynebacterium parvum: an adjunct to chemotherapy for resistant advanced ovarian cancer. | this is a prelimianry report of an effort to treat women with advanced (stage iii and iv) ovarian cancer who had progressive disease in spite of previous surgery, chemotherapy and/or radiation by a program of reductive surgery, intensive immune stimulation and combination chemotherapy. an initial laparotomy was done where possible to reduce tumor burden, and then all patients were given intravenous corynebacterium parvum (c.p.) in escalating doses over a 10- to 14-day period. cyclic chemotherapy ... | 1977 | 837334 |
| in vitro and in vivo cytotoxicity of adriamycin and daunomycin for murine macrophages. | in virto exposure of murine lymphoma cells to adriamycin and daunomycin (dm) for 24 hr resulted in comparable cytotoxicity as assessed by viable cell counts and inhibition of dna synthesis. the spontaneous dna synthesis of spleen lymphocytes in vitro was also equally affected by the two agents. however, when the in vitro effects of the two drugs on macrophage monolayers were investigated, dm was found to be at least four times more toxic than am. in vivo-administered dm was more suppressive than ... | 1977 | 837378 |
| distribution of chloramphenicol acetyltransferase and chloramphenicol-3-acetate esterase among streptomyces and corynebacterium. | chloramphenicol-3-acetate esterase activity was detected in cell-free extracts of strains of streptomyces venezuela, streptomyces sp. and streptosporangium viridogriseum var. kofuense which produced chloramphenicol and also corynebacterium hydrocarboclastus which produced chloramphenicol analogs (corynecins). none of the cell-free extracts of chloramphenicol- or corynecin-producing strains possessed chloramphenicol acetyltransferase activity under conditions which avoided the influenced of the e ... | 1977 | 838634 |
| chemoattractant properties of corynebacterium parvum and pyran copolymer for human monocytes and neutrophils. | both pyran copolymer and the burroughs-wellcome vaccine of corynebacterium parvum were able to elicit a migratory response by human neutrophils or monocytes when incubated with serum. however, in the absence of serum, neither agent elicited such a response. the generation of the chemotactic factor by pyran was dependent on heat-labile components in the serum, while suggested involvement of the complement sequence. conversely, the migratory response of c. parvum in heated serum was equivalent to ... | 1977 | 839571 |
| the influence of nonspecific immunotherapy on the course of murine melanoma. | bcg, corynebacterium parvum, vitamin a, and levamisole were continuously administered to c57 bl/6 mice bearing b16 melanoma prior to, with following tumor implantation as well as before and coincident with surgical excision of the implanted tumor. only the group given levamisole prophylactically for 8 weeks before tumor inplantation showed a significant difference from control mice but a tenfold increase in dosage in this drug did not exert a comparable effect. | 1977 | 839793 |
| corynebacterium parvum and cyclophosphamide as combination treatment for a murine mammary adenocarcinoma. | weekly i.p. injections of killed corynebacterium parvum and of cyclophosphamide (given on different days) strongly inhibited growth of a transplantable murine mammary adenocarcinoma. a significant portion (40 to 80%) of animals could be made tumor free by means of combined therapy. no tumor-free survivors were obtained with c. parvum alone, and tumor-free mice were obtained with cyclophosphamide alone only at the expense of a high incidence of deaths due to drug toxicity. no evidence of tumor re ... | 1977 | 844041 |
| coryneform bacterial endocarditis: difficulties in diagnosis and treatment, presentation of three cases, and review of literature. | three patients who had coryneform bacterial endocarditis affecting a prosthetic valve are presented and 64 case reports are reviewed. diagnostic difficulties occur because coryneform bacteria often are fastidiuos, with long incubation periods, and often contaminate blood cultures. although some coryneform bacteria are killed by penicillin g, many are resistant to most of the commonly used antibiotics. vancomycin is bactericidal in resistant strains studied. treatment with vancomycin is indicated ... | 1977 | 846220 |
| infective endocarditis--a changing spectrum. | 1977 | 846225 | |
| anaerobic bacteria in otitis media. | anaerobic bacteria, peptostrepotococcus intermedius and propionibacterium acnes, were found in mixed culture specimens from four to ten tested cases of chronic secretory otitis media. these anaerobic bacteria were in a mixed infection flora with aerobic bacteria most often staphylococcus epidermidis and cornybacterium sp. which do not fit any established species. the findings of anaerobic bacteria in otitis media is consistent with the sporadic report of the involvement of anaerobic bacteria in ... | 1977 | 848830 |
| microbiological profiles of the viking spacecraft. | planetary quarantine requirements associated with the launch of two viking spacecraft necessitated microbiological assessment during assembly and testing at cape canaveral and the kennedy space center. samples were collected from selected surface of the viking lander capsules (vlc), orbiters, (vo), and shrouds at predetermined intervals during assembly and testing. approximately 7,000 samples were assayed. levels of bacterial spores per square meter on the vlc-1 and vlc-2 were 1.6 x 10(2) and 9. ... | 1977 | 848957 |
| microbiological degradation of bile acids, further degradation of a cholic acid metabolite containing the hexahydroindane nucleus by corynebacterium equi. | 1. the further degradation of a cholic acid (i) metabolite, (4r)-4-[4alpha-(2-carboxyethyl)-3aalpha-hexahydro-7abeta-methyl-5-oxoindan-1beta-yl]valeric acid (iia), by corynebacterium equi was investigated. this organism effected ring-opening and gave (4r)-4-[2alpha-(2-carboxyethyl)-3beta-(3-carboxypropionyl)-2beta-methylcyclopent-1beta-yl]valeric acid (vi). the new metabolite was isolated as its trimethyl ester and identified by partical synthesis. it was not utilized by c. equi. 2. (4r)-4[4alph ... | 1977 | 849290 |