Publications

tolerance of bacteria to extreme gas supersaturations.		1978	369563
effect of the mer tubercle bacillus fraction on the responsiveness of mice to t-independent antigens.	the effect of treatment with the methanol extraction residue (mer) mycobacterial fraction on the immunological responsiveness of balb/c mice to the t-independent antigens pneumococcal polysaccharide type iii (siiii) and trinitrophenyl-lipopolysaccharide conjugate (tnp-lps) was ascertained. pretreatment with mer prevented the establishment of immunological paralysis by threshold doses (10 or 15 microgram) of siii and by a paralyzing dose of 100 microgram tnp-lps. the induction of immunological pa ...	1979	370026
[variations in the phagocytic potency of circulating leukocytes from rats which received a thermal injury. effects of an immunostimulation with corynebacterium granulosum (author's transl)].	experiments were carried out to study in vitro the variations of phagocytic activity of circulating leukocytes from rats which received a thermal injury and were either immunostimulated or not by a single iv injection of c. granulosum. the thermal injury which was applied at about 10 percent of the body surface was of an intermediary type ; it developed towards necrosis before cicatrising on about the 30th day. phagocytic activity was expressed as the percentage of "active" phagocytes or of thos ...	1978	370744
[immune therapy trial with corynebacterium in patients with e.n.t. cancer. (code name of the trial: "reticulo-stimuline")].		1978	371488
factors affecting isolation and identification of haemophilus vaginalis (corynebacterium vaginale).	the rate of isolation of organisms resembling haemophilus vaginalis (corynebacterium vaginale) from vaginal specimens was not significantly affected by anaerobic versus carbon dioxide incubation atmospheres or whether specimens were inoculated on isolation media immediately after collection or after a delay of 6 h. forty-one clinically isolated strains were provisionally divided into 30 h. vaginalis strains and 11 h. vaginalis-like (hvl) strains based on morphological and growth characteristics. ...	1979	372217
the variable response of bacteria to excess ferric iron in host tissues.	the enhancement by exogenous ferric iron, both systemic and local, of the infectivity of 120 strains of bacteria, representing 17 genera, was measured in the skin of guinea-pigs. systemic iron enhanced only 23% of 115 strains, and local iron 49% of 71 strains. systemic iron, by an apparently anti-inflammatory action, depressed the size of lesions produced by 27 of the non-enhanced strains from nine of the genera tested. for most strains, the degree of enhancement was small, ranging from 2- to 8- ...	1979	372534
stimulation of rna synthesis in l-929 cells by rabbit tumor necrosis factor.		1979	372951
host defenses in murine malaria: successful vaccination of mice against plasmodium berghei by using formolized blood parasites.	infections of normal icr mice with the nyu-2 strain of plasmodium berghei (pb) are uniformly fatal. however, a proportion of mice that have been vaccinated with a formalin-killed antigen prepared from the blood stages of pb survive an otherwise lethal challenge. such immunity is not induced by immunization with normal mouse erythrocytes. the level of acquired anti-malarial immunity is related to the size and number of doses of antigen, and intravenous injection is superior to the subcutaneous ro ...	1979	373471
fluorescent antibody technique in the diagnosis of corynebacterium pseudotuberculosis.		1978	373819
active specific immunotherapy with tumor cells and corynebacterium parvum: a phase i study.	autologous, irradiated (10,000 rads) tumor cells mixed with c. parvum were given as weekly intracutaneous injections to fifteen patients with residual malignant disease. the toxicity was minimal and distinctly less than has been seen with tumor cell-bcg immunotherapy. a goal of 4 injections of 10(7) cells each was possible in only 4 patients because of limitations in methods of disaggregation and quantity of tumor available. the feasibility aspects are discussed and a case report of a prolonged ...	1979	376096
defective tumoricidal capacity of macrophages from a/j mice. i. characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli.	macrophages from a/j mice fail to develop tumoricidal activity after any of several in vivo or in vitro treatments that activate cells from c3h/hen mice. peritoneal macrophages from a/j mice treated i.p. with viable mycobacterium bovis, strain bcg, killed corynebacterium parvum, or pyran copolymer fail to develop in vitro tumoricidal activity; varying the numbers of macrophages from treated mice added to target cells, or the dose and time of treatment, or the treatment schedule of these in vivo ...	1979	376720
in vitro killing of schistosomula of schistosoma mansoni by bcg and c. parvum-activated macrophages.	resistance to schistosoma mansoni infection in the mouse has been induced either specifically by a primary infection with this parasite or nonspecifically by a variety of immunostimulants such as bcg. in the present study we developed an in vitro system to examine the effector mechanism of nonspecifically induced resistance. activated macrophage monolayers obtained from bcg- or corynebacterium parvum treated mice killed a respective mean 32 +/- 6% and 48 +/- 5% of schistosomula after 24 hr incub ...	1979	376723
detection of neonatal bacteremia.		1979	376806
effect of adriamycin and corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells.	administration of adriamycin and corynebacterium parvum alone in c57bl/6j mice bearing lewis lung carcinoma stimulated the direct (19s) and indirect (7s) plaque-forming cell (pfc) response specific for sheep red blood cells. thus adriamycin appears to possess some immunostimulatory effect on tumor-bearing mice with much less effect than c. parvum alone. simultaneous administration of adriamycin and c. parvum decreased the pfc response compared to that for c. parvum alone. this decrease may indic ...	1979	379400
corynebacterium parvum: effects on the biochemistry of mouse serum and liver.		1979	379402
infection due to corynebacterium species in marrow transplant patients.	a corynebacterium species consistently resistant to all antibiotic therapy except vancomycin caused bacteremia in 32 of 284 (11%) marrow transplant patients. twenty-one patients had colonization or infection before bacteremia. twenty-six of the 32 patients were males, and males older than 16 years were infected significantly more often than females over 16, or than all patient under 16. a case-control study showed that infected patients had greater exposure to antibiotics; more often had failure ...	1979	380432
subcutaneous corynebacterium parvum in bladder cancer: a controlled study of its immunological effects.	fourteen out of 26 patients with invasive bladder cancer were randomly assigned to receive weekly subcutaneous injections of corynebacterium parvum (cp) in addition to standard treatment. peripheral blood t lymphocyte percentage, k cell activity, mitogen responsiveness, and monocyte and polymorph leucotaxis were measured at intervals over a period of 1 to 2 years. the only consistent difference between the cp-treatment patients and the controls was a slightly higher level of k cell activity in t ...	1979	380732
tuftsin-macrophage interaction: specific binding and augmentation of phagocytosis.	the binding of [3h]tuftsin to normal and in vivo stimulated mouse peritoneal macrophage populations was studied at 22 degrees c. the [3h]tuftsin binding to thioglycollate-stimulated macrophages was shown to be rapid and saturable, with an equilibrium dissociation constant (k(d)) (calculated from a scatchard plot) of 5.3 x 10(-8) m. the calculated number of binding sites per macrophage amounts to approximately 72,000. binding competition studies with unlabelled tuftsin yielded a k(d) of 5.0 x 10( ...	1979	381320
the role of immunotherapy in the management of patients with malignant melanoma.		1979	382645
cyclophosphamide plus 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (dtic) with or without corynebacterium parvum in metastatic malignant melanoma.	one hundred twenty patients with metastatic malignant melanoma were randomized to receive either cyclophosphamide, 600 mg/m2 iv, on day 1 plus dtic 200 mg/m2 iv days 1 through 5, or the same chemotherapy plus c. parvum 5 mg/m2 iv on day 8 and day 15. therapy was repeated every 21 days. although responses were observed in 13.8% of patients on cyclophosphamide plus dtic versus 25.5% of patients on cyclophosphamide plus dtic plus c. parvum, the median duration of remission was 15.6 weeks on chemoth ...	1979	383276
hybrid resistance to el-4 lymphoma cells. i. characterization of natural killer cells that lyse el-4 cells and their distinction from marrow-dependent natural killer cells.	natural killer (nk) cells from nonimmunized mice capable of lysing el-4 (c57bl/6 strain h-2b) tissue culture-adapted lymphoma cells have been analyzed and compared with nk cells which lyse yac-1 (a-strain, h-2a) lymphoma cells. a correlation was seen in the ability of inbred and b6d2f1 mice to reject c57bl/6 (b6) bone-marrow grafts and the ability of their spleen cells to lyse el-4 cells in vitro. this suggests that hybrid or hemopoietic histocompatibility antigens, (hh-1b), relevant in the reje ...	1979	383877
direct effects of corynebacterium parvum and bcg on human monocyte-mediated tumour cell cytostasis in vitro.	four strains of corynebacterium parvum (cp) and bcg induced low levels of cytostatic ability to a human tumour cell line in human monocytes when added directly to conventional monocyte cultures. the cytostatic ability induced by mediators from autologous lymphocytes stimulated with the same agents was greater than that produced by direct addition to monocytes. bcg was more efficient in stimulating lymphocyte dna-synthesis and lymphokine release than any of the cp strains tested. in order to test ...	1979	386712
functional characterization of mouse lymphocyte subpopulations identified by their natural binding of bacteria. i. identification of the ig-secreting cell subpopulation.	three mouse b cell subpopulations (b1, b2 and b3) can be identified by their natural binding of bacteria. to determine whether these subpopulations have unique functions, we assayed the number of anti-srbc-secreting cells and the number of ig-secreting cells in unseparated populations and in populations in which the b2 and b3 cells were removed by immobilized monolayers of escherichia coli-2, a bacteria that binds b2 and b3 cells. essentially all of the plaque forming cells present in the unsepa ...	1979	387875
[morphogenetic features of sulfobacillus thermosulfidooxidans].	the morphogenesis of sulfobacillus thermosulfidooxidans bkm b-1269 was studied by electron microscopy at the vegetative stage of growth on a medium with pyrite as the source of energy. young growing cultures of this organism were found to be very polymorphous: along with rod-like cells of various dimensions (0.6--0.8x1.0--3.0 mcm) which were predominant, coccoid, pyriform, clavate and dumbbell-like cells were also encountered. certain cells have a tendency for branching. the cells can divide by ...	1979	388160
[breast cancer: a dynamic approach of cellular immunity and immunostimulation with an immunoadjuvant: p40 fraction. (author's transl)].	the study of the immune status of breast cancer patients with delayed hypersensitivity skin tests reveals a clear immune deficiency in comparison with a reference patients group. this immunstatus was significantly improved by an immunstimulation with the p40 fraction. the responsive capacity to an immunstimulation appears independant of the lymphnodes involvment, whereas, on the contrary, the initial degree of immune deficiency appears connected. the p40 fraction has an immunstimulant effect com ...	1979	388318
inhibition of haemophilus vaginalis (corynebacterium vaginale) by metronidazole, tetracycline, and ampicillin.	the minimal inhibitory concentrations (mics) of ampicillin, tetracycline, and metronidazole for 71 strains of haemophilus vaginalis (corynebacterium vaginale) were compared by use of an agar-dilution method and an inoculum of 10(6) organisms/ml. all strains were sensitive to 1 microgram of ampicillin/ml, 70% to 4 micrograms of tetracycline/ml, and only 13% of the strains to 8 micrograms of metronidazole/ml. under anaerobic conditions the susceptibility to metronidazole increased markedly, and 48 ...	1979	388682
the effect of bcg-vaccination on vaccinia virus infections in mice.	pretreatment with bcg yielded a high degree of protection against experimental vaccinia virus infections in mice. corynebacterium parvum and aristolochia acid were less protective; other immunostimulants were ineffective.	1979	389657
purification and some properties of hemolysin produced by corynebacterium pyogenes.		1979	390193
antibody coated bacteria in urine sediment from cattle infected with corynebacterium renale.	using the fluorescent antibody test, the presence of antibody-coated bacteria in 10 out of 17 urine sediment samples from cattle infected with corynebacterium renale is described. these antibodies were mainly of the immunoglobulin class igg, and to a lesser extent iga. this finding is characteristic for infections of the upper urinary tract (pyelonephritis). in seven samples no antibody coating of the bacterial surface was detected. in these cases an infection of the lower urinary tract (cystiti ...	1979	390848
a cystic jaw lesion in sheep.		1979	390850
diagnostic availability of the hemolytically active exosubstance of corynebacterium pseudotuberculosis for isolation and identification of streptococcus agalactiae and its comparison with the beta-toxin of staphylococcus aureus.		1979	393011
chemoimmunotherapy (dtic and corynebacterium parvum) as adjuvant treatment in malignant melanoma.	sixty-one patients with stage i or ii (lymph node involvement) malignant melanoma were prospectively randomized into a control group receiving surgical treatment only (consisting of wide excision of primary and regional node dissection) and a group receiving the same surgical treatment plus adjuvant therapy with dtic and corynebacterium parvum. followup times ranged from 1 1/2 to 4 years. among the 29 patients in the surgical control group, there were five hematogenous recurrences and one region ...	1979	393377
human monocyte-mediated cytotoxicity to k-562 cells: activation by lymphokines.	human monocytes purified by adherence and prolonged in vitro monolayer culture were activated by supernatants of autologous lymphocytes stimulated with live bacillus calmette-guérin or killed corynebacterium parvum. activated monocytes expressed increased ability to lyse k-562 cells prelabelled with methyl-3h-thymidine in a 48 h assay. activation could be detected at a 1:64 dilution of lymphokine supernatants. target cell killing by activated monocytes was strongly influenced by the density of t ...	1979	396667
[contribution to an epidemiological study and the pathogenesis of caseous lymphadenitis of sheep (author's transl)].		1979	397037
in vitro influence of endotoxin on human mononuclear phagocyte structure and function. 2. enhancement of the expression of cytoststic and cytolytic activity of normal and lymphokine-activated monocytes.	the presence of non-toxic concentrations of e. coli endotoxin (lps) during the in vitro interaction of normal human monocytes and a human tumour cell line (nhik 3025) enhanced monocyte-mediated target cell cytostasis and cytolysis. monocyte responsiveness to lps was greatest at an intermediate stage of in vitro differentiation. the expression of cytostatic and cytolytic activity by human monocytes activated with mediators from corynebacterium parvum-stimulated human lymphocytes was also enhanced ...	1979	397718
[immunofluorescence tests for the detection of antibodies against corynebacterium pyogenes and streptococci in blood serum and vaginal mucus of cattle].	bacteriological tests were applied to cattle with endometritis and vaginitis. included were cervical mucus samples and immunofluorescence tests to detect in that mucus as well as in blood serum antibody to corynebacterium pyogenes and streptococcus haemolyticus. the results pointed at intensive contact of the animals with the above pathogens and to their frequent occurrence in cervical mucus of cattle afflicted with endometritis and vaginitis. they also supported the assumption of localised anti ...	1979	398201
analysis and control of mixed cultures.		1979	398222
isolation of mycoplasmas from milk, lungs, and prepuce of cattle.		1979	398242
[evaluation of antimicrobial activity of indol alkaloids].	in pursuing the study of the antimicrobial properties of alkaloids prepared from cuban plants the activity of 10 indol alkaloids and 4 semisynthetic variables obtained from three plants--catharanthus roseus g. don., vallesia antillana wood and ervatamia coronaria staph, of the family apocynaceae--growing in cuba was assessed in vitro. the alkaloids and the variables used were catharantine, vindoline, vindolinine, perivine, reserpine, tabernaemontanine, tetrahydroalstonine, aparicine, vindolinic ...	1979	399043
phagosome/lysosome fusion: a possible prerequisite for the enhancement of antibody responses in vitro by bcg, mycobacterium leprae and corynebacterium parvum.	primary in vitro antibody responses to srbc were suppressed in cultures prepared from the spleens of cba mice injected i.v. 20 days previously with 10(8) liver bcg. in contrast, cultures prepared from mice injected with dead bcg showed enhanced responses. in vitro spleen cell responses of the mice had returned to normal levels 4--6 weeks after their injection, but if dead bcg, m. leprae or c. parvum was added to the cultures, responses were enhanced. the enhancing effect of the added bacteria co ...	1979	399339
myelopoietic enhancement by immunoadjuvants: in vitro studies for their rational use in neutropenic patients.	following marrow transplantation, the clinical course of the patients is invariably complicated by severe infections due to neutropenia and immuno-incompetence. with a view to explore means of alleviating these complications, bacillus calmette-guerin (bcg), methanol extraction residue of bcg (mer), corynebacterium parvum (c. parvum) and pyran were examined for their myelopoietic activity on human marrow. light density (less than or equal to 1.077 g/ml) unfractionated (uf) cells (2 x 10(6)/ml and ...	1979	400687
adjuvant intralesional and systemic corynebacterium parvum immunotherapy for surgically treated head and neck cancer.		1978	401122
fatty and mycolic acid composition of bacterionema matruchotii and related organisms.	whole-organism methoanolysates of bacterionemae contained mycolic acids in addition to other long-chain fatty acids. these mycolic acids were similar in general structure and overall size to those found in strains of corynebacterium diphtheriae and corynebacterium xerosis. the long-chain fatty acids of bacterionemae, mainly straight-chain saturated and unsaturated acids, were similar to those of certain coryneform bacteria including c. diphtheriae. on the basis of these lipid data, and results o ...	1977	401865
serum effects on the response of mammalian cells to the exotoxins of pseudomonas aeruginosa and corynebacterium diphtheriae.	the response of mammalian cells to pseudomonas and diphtheria exotoxins was studied. a method was developed whereby the sensitivity of cells to these two toxins could be quantitated. the method is versatile and can be used to study the effects of toxins on many cellular metabolic or transport processes. the type of serum used in the culture medium significantly influenced the response of cells to the toxins. calf, horse, and human sera protected cells while fetal calf serum did not. precipitatio ...	1977	402176
[diphtheria epidemic in eastern switzerland in 1974].	a diphtheria epidemic in the eastern part of switzerland in 1974 and the measures which were taken for its management and eradication are described. in particular it is pointed out that at present diphtheria displays atypical clinical symptoms in europe, a fact that renders the diagnosis very difficult in many cases. therefore, it is important to perform a throat swab in every patient with suspected diphtheria; it is also necessary to explicitly require a search for c. diphtheriae. the early rec ...	1977	403601
enumeration and identification of human leukemic lymphocytes by their natural binding of bacteria.	the recently described property of bacteria to bind to human lymphocytes was used to distinguish between normal and chronic leukemic lymphocyte (cll) populations. strains of the following bacteria were used in this study: arizona hinshawii, escherichia coli strains 1 and 2, bacillus globigii, brucella melitensis, corynebacterium diphtheriae strains 1 and 2, corynebacterium xerosis, sarcina lutea, staphylococcus aureus, and staphylococcus epidermidis. for identification of immunoglobulin-bearing ...	1977	404035
[diphtheria].		1977	404227
antitumor activity of a brucella abortus preparation.	mice injected intraperitoneally with sarcoma-180 cells develop ascites and eventually die. intraperitoneal injection of a nonviable, aqueous... ether-extracted brucella abortus preparation (bru-pel) as early as 7 days before or as late as 7 days after injection of tumor cells significantly inhibited development of ascites and protected against death. bru-pel was not effective if injected after ascites was grossly apparent. bru-pel was significantly more active than a corynebacterium parvum prepa ...	1977	404249
precipitating antibody against protease of corynebacterium pyogenes in pigs.	antibody in sera from pigs carrying an abscess associated with corynebacterium pyogenes and healthy pigs was examined by the agar gel diffusion test. in the test, the concentrated culture fluid containing the protease of c. pyogenes was used as antigen. as a result, precipitating antibody was demonstrated in sera from 25 of 30 abscessed pigs and a few of the healthy pigs. when the relationship between precipitating antibody and protease was examined by the immunoelectrophoresis and gel filtratio ...	1977	404574
mutations of corynephage beta that affect the yield of diphtheria toxin.		1977	404756
[molecular weight of bacterial toxins].		1977	404803
[role of oxygen in controlling the process of c. diphtheriae cultivation].		1977	404809
bacteremia after upper gastrointestinal endoscopy.	during 24 months, 200 upper gastrointestinal endoscopies were performed on 193 patients. blood cultures were obtained before and five and 30 minutes after the procedure using thiol (50 ml) and trypticase soy broth (100 ml) media. the mean endoscopic time was 34 minutes. sixteen patients developed bacteremia (8%). twelve groups of microorganisms were detected in positive blood cultures: streptococcus (5 species), lactobacillus sp, veillonella alcalescens, staphylococcus aureus, staph epidermidis, ...	1977	404974
differentiation of streptococci from diphtheroids.		1977	405070
identification of five human lymphocyte subpopulations by their differential binding of various strains of bacteria.		1977	405106
studies on cutaneous diphtheria in and around delhi.		1977	405317
diphtheroid osteomyelitis.	isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants, as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic (one in pure culture and two in mixed cultures). previous operation or other factors that compromise host resistance create the setting for these opportunistic organisms. penicillin with or without streptomycin is the treatment of choice, but if penicillin o ...	1977	405396
acute otitis externa in divers working in the north sea: a microbiological survey of seven saturation dives.	saturation diving is an important and widely used technique in the offshore oil industry. during 1974-5 two saturation dives in the north sea were terminated because of outbreaks of incapacitating otitis externa, and others were disrupted. pseudomonas aeruginosa was consistently isolated from the ears of affected divers. because complex work schedules were threatened seven subsequent dives were subjected to microbiological monitoring and control. colonization of ear canal with p. aeruginosa or w ...	1977	405421
[effectiveness of a hemolyzed preparation for isolation of pure cultures of diphtheria bacilli].		1977	405555
[relationship between the culture medium and the fatty acid composition of diphtheria and non-pathogenic corynebacteria].	the gasochromatic method was applied to the study of the cellular fatty acids composition in diphtheria and nonpathogenic corynebacteria (diphtheroids and psendo diptheria bacillus). marked differences in the content of unsaturated fatty acids were revealed in them. thus, palmito leic acid served the preponderant unsaturated fatty acid in corynebacteria diphtheriae, and unsaturated fatty acids with 18 carbon atoms (octadeconoic and linoleic)--in nonpathogenic corynebacteria. the mentioned change ...	1977	405825
[radioprotection conferred by corynebacterium parvum against the lethality caused by x irradiation at sublethal and lethal doses in the mouse].	intraperitoneal injection of corynebacterium parvum (c. parvum) into balb/c mice produces a protection against toxicity or lethality provoked by ionizing radiation (750 r and 950 r). survivals reaching nearly 90 days have been recorded.	1977	406088
toxin production by strain c7 (beta), its mutants and their l-phase variants of corynebacterium diphtheriae.		1977	406436
respiratory pathogens in non-human primates with special reference to corynebacterium ulcerans.	an investigation of 272 non-human primates (75 macacca cynomolgus, 97 macacca mulatta and 100 cercopithecus aethiops) revealed a high incidence of respiratory disease caused by corynebacterium ulcerans, staphylococci, diplococci and streptococci. escherichia coli was also found as a secondary invader. most of the infections occurred during winter in macaca cynomolgus and were caused by corynebacterium ulcerans and diplococcus pneumoniae. the c. ulcerans strains were phage type vi g. a phage typ ...	1977	407395
heat-inducible mutants of corynebacteriophage.	heat-inducible mutants of temperate cornebacteriophage beta and gamma, called temperature-sensitive repression (tsr) mutants, were isolated and characterized. lysogens carrying these mutants were induced at 38 degrees c, produced a normal or slightly increased yield of phage, and underwent extensive lysis at this temperature. in some cases mutation to heat inducibility had altered the uv inducibility of the phage, the changes ranging from loss to enhancement of this trait. complementation tests ...	1977	408516
bacteriophage production by doubly lysogenic corynebacterium diphtheriae.	parental and recombinant phage production by tandem, double lysogens of corynebacterium diphtheriae was studied in strains in which the coupling of prophage markers and the order of prophage was established. the results from studies of mass lysates and single bursts showed that the recombinant class of phage, designated r1, was predominant in uv-induced lysates followed by the parental, p1 class and to a lesser extent the p2 and r2 classes. single bursts of uv-treated cells contained phage from ...	1977	408517
carriage of non-toxigenic corynebacterium diphtheriae by australian aboriginals.	a survey of 200 aboriginals in western australia revealed five carriers of non-toxogenic corynebacterium diphtheriae; four of these were variety mitis and one was variety gravis.	1977	408595
antitumor activity of propionibacterium acnes (corynebacterium parvum) and isolated cytoplasmic fractions.	the tumor-inhibitory effect of an intralesional injection of propionibacterium acnes was of limited duration ("finite"). our model was the dba/2 syngeneic mouse injected with p815 mastocytoma cells (5 x 10(5)) into each rear footpad; only the left was treated, leaving the right as a "pseudometastasis." the finite effect occurred at approximately 21 days after the first treatment. subsequent i.p. treatments with p. acnes did not alter this effect, although they increased mean survival time. with ...	1977	409491
biochemical characters to differentiate strains of corynebacterium diphtheriae, c. xerosis and c. hofmannii.		1977	409666
isolation from corynebacterium diphtheriae c7(beta) of bacterial mutants that produce toxin in medium with excess iron.	five mutants that produce toxin in medium with excess iron were isolated from strain c7(beta). the iron content of bacteria grown on this medium was considerably higher than that of c7(beta) cells grown in medium containing the minimum amount of iron needed to inhibit toxin production. when the nonlysogenic, nontoxinogenic strain c7(-) was lysogenized with phages from each of the mutants, toxin production by all of the resulting lysogens, like that by parent strain c7(beta), ceased upon iron add ...	1977	409685
rifampin in the treatment of experimental brucellosis in mice and guinea pigs.	rifampin, a broad-spectrum antibiotic able to penetrate intracellularly, was used for treatment of infections with brucella melitensis in mice and brucella abortus in guinea pigs. treatments were administered for seven, 14, or 21 days; mice were given 25 mg of rifampin/kg per day, and guinea pigs 100 mg/kg per day. efficacy of the drug was determined by comparison of rifampin-treated animals with saline-treated controls and with tetracycline-treated mice (200 mg/kg per day) according to the foll ...	1977	409786
antimicrobial lipids: natural and synthetic fatty acids and monoglycerides.	over 40 natural or synthetic lipophilic compounds were screened for antimicrobial activity. gram (+) bacteria and yeasts but not gram (-) bacteria were affected by these agents. epimino and selena fatty acids are more active than their corresponding straight chain unsubstituted fatty acids. the position of selenium influenced the antimicrobial activity of the fatty acids. the presence and position of a double or triple bond, usually an important factor in long chain fatty acids (greater than c14 ...	1977	409896
micromorphology of gram-negative hydrogen bacteria. i. cell morphology and flagellation.	the cell morphology, the arrangement and fine structure of flagella and the piliation of the following gram-negative aerobic hydrogen bacteria have been studied: alcaligenes eutrophus, alcaligenes paradoxus, alcaligenes ruhlandii, pseudomonas flava, pseudomonas pseudoflava, pseudomonas palleronii, pseudomonas facilis, aquaspirillum autotrophicum, paracoccus denitrificans, corynebacterium autotrophicum, and strains ma 2 and sa 35. the identity of the bacteria was examined by their substrate spect ...	1977	410385
bacteriophage typing of corynebacterium diphtheriae.	bacteriophage types of over 3,000 strains of corynebacterium diphtheriae isolated in canada have been determined. the typing scheme used involved the use of nine phages. results indicated that phage types correlate with biotypes to a large degree. corynecin types were also determined for a limited number of cultures, and results indicated that the indicator strains presently available are unsuitable for the typing of c. diphtheriae strains isolated in north america. the distribution of phage typ ...	1977	410896
rapid identification of cell wall components as a guide to the classification of aerobic coryneform bacteria from human skin.	in a survey of over 1000 isolates of aerobic skin coryneforms from a wide variety of sources, chromatographic methods were used to identify the major cell-wall components in whole-cell hydrolysates. most of the skin isolates-like members of the genus corynebacterium--possessed meso-diaminopimelic acid and arabinose. however, substantial numbers of coryneforms apparently resident on the skin did not have this pattern; the sites from which they were isolated suggested that some were derived from t ...	1977	410934
[extracellular material of some representatives of the genus corynebacterium (the electron microscopic aspect)].	at the active developmental phases (up to 2 days) cells of toxigenic and nontoxigenic corynebacteria form extracellular vesicle-like material of two types which can be revealed both on whole cells set off by metal and stained negatively, and in ultrathin sections. extracellular material of the first type is a derivative of an extensive membranous coat of corynebacteria and is formed as a result of its fragmentation. vesicles of this type are devoid of electron microscope-dense content, have no t ...	1977	411293
[preliminary subdivision of corynebacteria related to c. diphtheriae var. gravis that ferment starch].		1977	411294
inhibition of diptheroid esterase by micrococcus luteus.	micrococcus luteus produced a diffusible, esterase inhibitory factor (eif) which inhibited the activity of cutaneous diphtheroid esterases on tween 80-cacl2 agar media. esterases of staphylococcus, micrococcus, bacillus, and serratia were not susceptible. eif did not appear to combine with the substrate or to prevent enzyme synthesis; it was unable to reverse the precipitation of calcium oleate. the composition of the medium, especially peptones, influenced the production of eif. eif was synthes ...	1977	411559
studies on the fine structure of corynebacterium diphtheriae-granules.	the seemingly homogeneous metachromatic and electron-scattering granules of corynebacterium diphtheriae have two structural components as revealed under conditions of low beam load and by use of ribonuclease. they contain high percentages of p and ca. findings point to participation of ribosomes and intracytoplasmic membranes in the formation of the granules.	1977	412349
studies on corynebacterial precipitinogens common to mycobacteria, nocardiae and rhodochrous.	ten strains of corynebacterium were analyzed by means of the comparative immunodiffusion technique employing reference precipitation systems from strains of mycobacterium, nocardia and the rhodochrous taxon. the test strains had precipitinogens in common with the reference strains. two of the intergenerical cross-reacting precipitinogens revealed were labelled x and y. two other precipitinogens (alpha,beta), earlier found to be common for strains of mycobacteria, nocardiae, and rhodochrous, were ...	1977	412795
[clinical and bacteriological criteria of genitaltract infections in male sterility (author's transl)].		1977	413179
[the species c. diphtheriae].	corynebacteria (c. diphtheriae var. gravis, mitis, minimus, intermedius, c. belfanti, c. ovis, c. ulceraus) producing diphtheria toxin are found as variants sharply differing from one another morphologically (from long branching rods to coccobacilli), culturally, biochemically and by other signs. the toxin synthesis in them was determined by genetically heterogeneous prophages tox+; tox+ virus exchange is possible between the corynebacteria. since production of specific toxin, the cardinal sign ...	1977	413292
effect of the combination of corynebacterium parvum and levamisole on murine tumors.		1977	413718
further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. v. comparison of the effects of tilorone hydrochloride, levamisole, methanol-soluble fraction of mycobacterium butyricum, bcg, and a nonviable aqueous ether extract of brucella abortus preparation in treatment of mice with tumors.		1978	413929
[problems of cancer immunotherapy (author's transl)].	active immunization has received a new impulse most recently through the treatment of tumor cells with the enzyme neuraminidase from vibrio cholerae. there is no passive specific immunotherapy in humans. in the field of unspecific active immunotherapy there are very many, partly contradictory, findings, especially with bcg, corynebacterium parvum and preparations from these and other organisms. a cellularly transmitted immunity has been attempted, but so far without very encouraging results. it ...	1977	414081
diphtheria corneal ulcers.	an adult with cutaneous diphtheria was admitted with bilateral purulent conjunctivitis and a perforated eye with most of the cornea absent due to corynebacterium diphtheriae. at the time of admission of grayish patch of corneal epithelium was noted in the other eye, and in the next 24 hours there developed a large corneal perforation with dissolution of much of the cornea. involvement of the external eye in diphtheria is rare but it is usually associated with cutaneous forms of the disease. cuta ...	1978	414704
determination of corynebacterium diphtheriae toxigenicity by a colorimetric tissue culture assay.	chinese hamster ovary (cho) cell cultures in microtiter wells are sensitive to growth inhibition and killing by picogram quantities of diphtheria toxin. in the absence of biologically active toxin, the cho cell culture produces sufficient acidic metabolites to change the phenol red ph indicator from pink to yellow within 56 h. in the presence of 10 pg of toxin per well, growth inhibition can be observed microscopically within 24 h. diphtheria toxin can be qualitatively assayed from culture super ...	1978	415068
the identification of six mouse lymphocyte subpopulations by their natural binding of bacteria.		1978	415087
relationship between beta converting and gamma non-converting corynebacteriophage dna.		1978	415247
mass spectrometry of acylated sugars as trimethylsilyl ether derivatives. a way for location of long chain fatty acyl groups.	the mass spectra of the trimethylsilyl ethers of the four positional isomers of methyl-o-palmitoyl-alpha-d-glucopyranoside have been studied, and the structures of the principal ions assigned by the use of exact mass measurements and deuterium labelling on the aliphatic chain, the trimethylsilyl group and the glucosidic methyl group. the origin of some fragments has been elucidated by analysis of reactions of metastable ions. the mass spectra of the different isomers exhibit major differences, w ...	1978	415769
studies on the immunostimulating and anti-tumour activity of a fraction isolated from corynebacterium granulosum.	the immunostimulating activity of the anaerobic corynebacteriae is well documented. fractions isolated from while cells have not been much investigated. we have reported that the immunostimulating activity is present in fractions isolated from corynebacterium granulosum. a few fractions have shown anti-tumour activity in grafted tumours in mice. one of these fractions (p 40) has been investigated in more detail, since it proved to be inhibitory when administered after grafting of the non-syngeni ...	1977	415918
the effect of corynebacterium parvum on the proliferation of monocyte precursors in the bone marrow of mice.	the anti-tumour activity of c. parvum is thought to be mediated via the monocyte/macrophage system (scott, 1974). these cells originate from rapidly dividing precursors in the bone marrow and it might be at this level that c. parvum exerts its action. to test this hypothesis bone marrow t0 swiss mice has been cultured according to the method of bradley and metcalf (1966), which gives an index of the number of proliferating macrophage precursor cells at the time of sacrifice. experiments were set ...	1977	415919
modified culture technique for corynebacterium diphtheriae isolation from desiccated swabs.	corynebacterium diphtheriae was isolated from pyoderma and ulcerative skin lesions with a modified delayed culture procedure as late as 9 weeks after field collection of silica gel-desiccated swabs. biotypes gravis and mitis were identified. most isolates were nontoxigenic. todd-hewitt broth enrichment enhanced recovery of c. diphtheriae by 70%.	1978	416036
fatty acids of gram-positive bacterial rods from human dental plaque.		1978	416814
pathogenesis of diphtheria carrier state from the immunological point of view.	results of a comparative investigation of diphtheria antitoxin and type-specific antibacterial antibodes in 264 carriers of diphtherial bacteria, 41 diphtheria patients and 263 non-infected subjects are presented. a high level of antitoxin did not prevent the development of toxigenic-strain carrier state. a basically similar immunological antibacterial response was observed in patients with manifest forms of diphtheria and in carriers of toxigenic strains; such a response could not as yet be det ...	1977	417135
[potentiation of immunologic memory by corynebacterium parvum and its mechanism].	immune response to bovine serum albumin (bsa) at dose of 2,50 mg/kg which is rather a weak immunogen in rabbits, when given intravenous was highly potentiated when the animals received a previous single intravenous infection of 2 mg/kg of c. parvum, followed by subsequent bsa anamnestic challenges for several months. thus, the antibody amounts synthesized following the 1st anamnestic injection (3 weeks) were 0,260 mg/ml in the control versus, 0,800 mg/ml in the c. parvum pretreated groups; follo ...	1977	417841
genetic transfers in mycobacteria.		1978	417980
serological and biochemical relationships between the alleged avirulent variant of corynebacterium kutscheri and streptococci of group n.	morphological, biochemical and serological observations suggested that no close relationship existed between c. kutscheri and its alleged avirulent variant isolated from mice at the rockefeller university. however, both capillary and double diffusion precipitin reactions showed the alleged variant to be a streptococcus of group n, indistinguishable from that previously isolated from rockefeller university mice.	1978	418113
[distribution of the taxonomic traits in coryneform bacteria].		1978	418310
natural killer cells may be the only cells in normal mouse lymphoid cell populations endowed with cytolytic ability for antibody-coated tumour target cells.	mouse normal lymphoid cells were analysed as to their ability to perform in three cytolytic systems: ability to act as 'natural killer', nk, cells against a nk sensitive tumour target, yac; as effector cells against igg-coated 815 cells, or to function as effector cells against igg-coated crbc. nk activity and adcc against the igg-coated p815 cells were found to vary in parallel as affected by age, organ distribution and genotype of the effector cells. on the other hand, adcc against crbc was la ...	1978	418499
[identification of corynebacterium diphtheriae by way of immunofluorescence (author's transl)].	the immunofluorescence technique (if) will be demonstrated as a time-saving method for identifying corynebacterium diphtheriae. in three test-series the if-test was performed on 74 strains of c. diphtheriae which had been isolated in a small case of epidemic in gelsenkirchen, on 4 strains of diphtheroids and on some strains to be found in the nasopharynx. all of these strains had been taken from blood agar, 69 toxinogenic strains of c. diphtheriae showed a clear, plainly reproducible fluorescenc ...	1978	418603