Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| effects of corynebacterium parvum on granulocyte/macrophage production and toxicity of chemotherapy. | 1977 | 305373 | |
| [immunotherapy of malignant diseases. a way towards the goal?]. | 1978 | 305530 | |
| haemophilus vaginalis (corynebacterium vaginale) vaginitis in women attending public health clinics: response to treatment with ampicillin. | haemophilus vaginalis (corynebacterium vaginale) was isolated from genital specimens from 150 women who came to a public health venereal disease clinic. forty-six patients returned to the clinic for at least one follow-up examination. of the returnees, 22 of 24 who initially had received adequate therapy (14 g ampicillin in seven days) were cured, compared with three of 22 who did not received adequate therapy (x2 = 25.11; p less than 0.00005). these data included significant cure rates with ade ... | 1978 | 306133 |
| induction of interferon production in mouse spleen cell cultures by corynebacterium parvum. | 1978 | 307432 | |
| is the adherent, non-specific 'suppressor' cell from rodent spleens an in vitro artefact? | mitomycin c-treated cells from the spleens of mice pre-treated with bcg, corynebacterium parvum, cyclophosphamide or methylcellulose will inhibit the mitogen responses of normal cells in vitro, but extended dose-response studies have shown that such cell populations will also enhance the response if added in very small numbers. the number of cells giving peak enhancement is proportional to the percentage of the spleen cells which are adherent at 72 hr. such late-adhering cells are not removed by ... | 1978 | 308422 |
| a role for t lymphocytes in tumour inhibition and enhancement caused by systemic administration of corynebacterium parvum. | 1978 | 308542 | |
| effect of corynebacterium parvum on human t-lymphocyte interferon production and t-lymphocyte proliferation in vitro. | 1978 | 309789 | |
| corynebacterium endophthalmitis. laboratory studies and report of a case treated by vitrectomy. | a corynebacterium sp was isolated from the vitreous humor under aseptic conditions on two separate occasions from a patient with endophthalmitis resulting from a penetrating injury by a metallic foreign body. the metallic foreign body was removed during a pars plana lensectomy and anterior vitrectomy procedure; intravitreously injected methicillin sodium, gentamicin sulfate, and dexamethasone sodium phosphate gave a functional visual result. intravitreous inoculation of rabbits with the coryneba ... | 1979 | 311191 |
| inhibition of memory cell-mediated cytotoxic response by systemic administration of corynebacterium parvum. | 1979 | 311692 | |
| separation of functionally distinct subpopulations of corynebacterium parvum-activated macrophages with predominantly stimulatory or suppressive effect on the cell-mediated cytotoxic t cell response. | 1979 | 312146 | |
| effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma. a sequential study over 28 days. ii. changes in non-specific (nk, k and t cell) lymphocytoxicity and delayed hypersensitivity skin reactions. | c. parvum and bcg produced significant changes in nk, k and t cell lymphocytotoxicity using a chang liver target cell. a consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. this was particularly marked for c. parvum and 'k' cell activity. skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. the importance of using lymphocyte concentration-cytotoxicity titration curves a ... | 1979 | 312169 |
| immunologic evaluation of patients with advanced head and neck cancer receiving weekly chemoimmunotherapy. | patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of t cells, fc receptor cells, and in derangements of t lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of development of delayed hypersensitivity to 2,4-dinitrochlorobenzene (70% of patients were dncb (-)). a population of phagocytic cells capable of decreasing lymphocyte responsiveness to mit ... | 1979 | 313240 |
| a trial of 5-fluorouracil and corynebacterium parvum in advanced colorectal carcinoma. | this study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum igm. serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, t-lymphocyte counts, b-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. in 33 patients chosen ... | 1979 | 313873 |
| effects of repeated corynebacterium parvum and bcg therapy on immune parameters: a weekly sequential study of melanoma patients. i. changes in non-specific (nk, k and t cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions. | increased lymphocyte cytotoxicity, particularly of 'killer' k cell type was recorded with repeated immunizations of either c. parvum or bcg. a 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. no marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. expression of cytotoxicity results as percentage 51cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymp ... | 1979 | 314367 |
| antibiotic susceptibility of haemophilus vaginalis (corynebacterium vaginale) to 21 antibiotics. | a total of 56 strains of haemophilus vaginalis were tested for their in vitro susceptibility to 21 antimicrobial agents by an agar dilution method. all strains were inhibited by 1 mug or less of penicillin, ampicillin, carbenicillin, and vancomycin per ml. the cephalosporins were less active; 4 mug of cefazolin per ml, 16 mug of cephalothin per ml, or 128 mug of cephalexin per ml was required to inhibit all strains. kanamycin, gentamicin, tobramycin, and neomycin were relatively inactive against ... | 1979 | 314776 |
| [preliminary considerations on the intravenous use of corynebacterium parvum in the treatment of solid neoplasms]. | 1979 | 315598 | |
| role of hemophilus vaginalis in vaginitis. | 1979 | 315713 | |
| value of immune monitoring in gynecologic cancer patients receiving immunotherapy. | immunotherapy with nonspecific immunopotentiators such as corynebacterium parvum is under study in several areas of gynecologic oncology. the efficacy of this new modality awaits the results of carefully done clinical trials designed to measure an improved effect on survival when this and similar agents are added to conventional therapy. this report deals with an attempt to demonstrate enhancement of the cell-mediated immune response in a small number of patients with advanced ovarian (18 patien ... | 1979 | 315714 |
| effects of endotoxin and extracts of pregnant mouse uterus on the recovery of hemopoiesis after 5-fluorouracil. | a single injection of endotoxin, 4 hours after administration of 150 mg/kg of 5-fluorouracil (5-fu), stimulated the recovery of bone marrow hemopoietic cells that form colonies in spleen (cfu-s) or in culture (gm-cfc), of erythropoiesis, and of platelet production. corynebacterium parvum injections had similar effects. endotoxin-free extracts of tissues (from pregnant mouse uterus, placenta, and embryo) which have a high content of the factor(s) capable of stimulating growth of gm-cfc in vitro a ... | 1979 | 316724 |
| lethal plasmodium yoelii malaria: the role of macrophages in normal and immunized mice. | mice were injected with silica or corynebacterium parvum, which, respectively, inhibit and stimulate macrophages in vivo, in an attempt to study the role of macrophages in lethal plasmodium yoelii infection and in mice protected by immunization. in the normal infection, macrophages were able to control parasitaemia for up to 1 week, whereas in immunized mice they appeared to inhibit the sterilizing immune response. a model is proposed in which this dual role of activated macrophages may account ... | 1979 | 317443 |
| inhibition of host resistance by nutritional hypercholesteremia. | previous experiments showed that nutritionally induced hypercholesteremia in mice caused an increase in susceptibility to coxsackievirus b, with a marked suppression of cellular infiltrates in infected tissues and an increased mortality. the present studies demonstrated that a hypercholesteremic diet was associated with an inhibition in host resistance as measured by susceptibility to listeria monocytogenes infection and the growth of two transplanted syngeneic murine tumors. moreover, the abili ... | 1979 | 317596 |
| response of lympho-hemopoietic tissue to corynebacterium parvum by study of dna enzymes and h3-tdr metabolism. | the effects of corynebacterium parvum on the lymphohemopoietic tissues of mice was investigated by h3-tdr metabolism, organ weights, dna-polymerase-alpha activity and terminal deoxynucleotidyl transferase (tdt) activity. marked increase in spleen size occurred. the increase in size was accompanied by increases in dna-p-alpha activity and h3tdr uptake. this indicated that the spleen was a major site of cell proliferation and of increase in population size after c. parvum stimulation. thymus and b ... | 1979 | 317898 |
| [levamisole as an immunostimulating factor]. | levamisole--(l)--1-2, 3, 5, 6--tetrahydro-6- phenylimidazo (2, 1-b)-- thiazol monohydrochloride, a simple chemical, first introduced as a broad spectrum antihelmintic , has been recently on the list of the nonspecific active immunostimulants together with bcg, corynebacterium parvum, polyribonucleosides and transfer factor (tf). this, however, is oversimplification and may cause some confusion because levamisole, in contrast to the so-called immunostimulants, does not stimulate immunity above th ... | 1979 | 318115 |
| corynebacterium equi in human faeces. | 1979 | 318474 | |
| tetrahydrofolate-dependent biosynthesis of ribothymidine in transfer ribonucleic acids of gram-positive bacteria. | trimethoprim, an inhibitor that prevents tetrahydrofolate-dependent transmethylation reactions inbacteria, was used in a comparative study to discriminate between two possible biosynthetic pathways, either the s-adenosylmethionine or the tetrahydrofolate-dependent formation of ribothymidine (rt) in transfer ribonucleic acids (trna's) of several strains of gram-positive and gram-negative microorganisms. rt-deficient trna's accumulate in trimethoprim-treated gram-positive streptococcus faecium, st ... | 1977 | 318638 |
| prosthetic valve endocarditis by opportunistic pathogens. | the incidence of endocarditis produced by the so-called "opportunists" as a complication of prosthetic valve surgery is progressively increasing in frequency and gradually transforming the clinical picture habitually associated with this disease. we report six cases of endocarditis produced by opportunistic microorganisms (two cases by candida, and the remaining by serratia, actinobacillus, acinetobacter calcoaceticus, and bacteroides fragilis, and by corynebacterium diphtheriae) in four male an ... | 1977 | 319774 |
| a comparison of pyrogenicity and related properties seen in a suspension of corynebacterium parvum and a gramnegative organism. | when the pyrogenic properties of c. parvum and a gramnegative organism, s. typhimurium, were compared it was found that the onset of the pyrogenic response to c. parvum was delayed relative to that of s. typhimurium and that secondary responses rarely occurred. in further experiments the interaction of c. parvum and s. typhimurium was studied. although synergism was not demonstrated, the kinetics of the response to mixtures of the two vaccines was anomalous while pre-treatment of rabbits with c. ... | 1977 | 320069 |
| protection of mice against babesia spp. and plasmodium spp. with killed corynebacterium parvum. | mice which had been pre-treated with killed corynebacterium parvum given intravenously or intraperitoneally, but not subcutaneously, were completely resistant to infection with babesia microti or b. rodhaini, and were protected from death caused by plasmodium vinckei or p. chabaudi infection. there is evidence that the parasites died within circulating erythrocytes. this occurred much too soon for a specific antibody response to be evoked, and no antibody could be detected by the indirect fluore ... | 1977 | 320544 |
| [chronic tonsillitis probably caused by corynebacterium pyogenes var. hominis]. | 1977 | 321977 | |
| immunotherapy of cancer. | clinical studies have indicated a close relationship between immunological competency and the growth of human cancer. studies in animal systems have indicated that immunological mechanisms are important in host-tumor existence. a number of agents are in the process of being evaluated for their immunotherapeutic potential in patients with cancer. these include levamisole, bacille calmette guérin (bcg) and corynebacterium parvum. while the precise role of these agents in the treatment of human mal ... | 1977 | 322390 |
| [treatment of solid tumours by intratumoral injection of immunostimulants]. | intra-lesional injections of immunostimulants--bcg or corynebacterium parpum--induced a local cure of the mcfifj2(s) tumour and a remote therapeutic effect. when applied to rats multigrafted with the mcfifi2(s) tumour, local and distant cures were obtained in some situations. this indicates the likely intervention of a specific immune mechanism. quantilating the pulmonary metastasis in combination with local treatment of lewis mouse tumours showed that bcg plus c. parvum injected into the tumour ... | 1977 | 322574 |
| tellurite reduction test to aid in the recognition of corynebacterium vaginale. | corynebacterium vaginale (haemophilus vaginalis) does not reduce potassium tellurite. when a 1% aqueous solution of tellurite is added to starch agar plates previously inoculated with vaginal discharge material, other starch-fermenting and most non-starch-fermenting bacteria rapidly reduce tellurite to produce black or gray colonies. this test is a useful adjunct to methods for rapid presumptive identification of c. vaginale. c. vaginale is more susceptible to tellurite inhibition than a variety ... | 1977 | 323282 |
| functional heterogeneity in macrophages activated by corynebacterium parvum: characterization of subpopulations with different activities in promoting immune responses and suppressing tumor cell growth. | peritoneal cells (pec) from mice injected i.p. with heat-killed corynebacterium parvum (cp) showed enhanced immunostimulatory (accessor or a cell) activity as measured by their ability to restore the immune responsiveness of nonadherent spleen cells to sheep erythrocytes (srbc) and polymeric flagellin (pol) of salmonella adelaide in vitro. this was true whether the pec and nonadherent spleen cells were in direct contact or separated by a cell-impermeable membrane which allowed the free passage o ... | 1977 | 323353 |
| effects of bcg and corynebacterium parvum on the haemopoietic precursor cells in continuously irradiated mice: possible mechanisms of action in immunotherapy. | 1977 | 324769 | |
| effect of anti-thymocyte serum, anti-macrophage serum, and latex particles on the therapeutic efficacy of bcg or corynebacterium liquefaciens (propionibacterium acnes c7) in syngeneic mice. | in a syngeneic mouse-tumor system, anti-thymocyte serum, anti-macrophage serum, and latex particles were used for a comparative study of the immunotherapeutic efficacy of intradermal inoculation of tumor cell-bcg and tumor cell-corynebacterium liquefaciens (=propionibacterium acnes c7) vaccines. anti-thymocyte serum treatment nullified suppression of tumor mediated by bcg (living and nonliving) and living c. liquefaciens. however, the effect of nonliving c. liquefaciens was not affected so much ... | 1977 | 324858 |
| corynebacterium equi infection complicating neoplastic disease. | corynebacterium equi, a soil-residing diphtheroid pathogenic in horses, swine and cows, caused pulmonary infection with bacteremia in two patients with lymphomas. both patients were being treated with immunosuppressive therapy, as were the patients in three previously reported human cases. unless certain characteristics of these organisms are recognized, they may be regarded as normal flora or contaminating diphtheroids. they could also be mistaken for other gram-positive rods, such as bacillus ... | 1977 | 326031 |
| pathologic changes in the milk and udder of cows with mastitis. | 1977 | 326732 | |
| bovine mastitis produced by corynebacteria. | 1977 | 326735 | |
| microbial agents and bovine mastitis. | 1977 | 326738 | |
| [newer veterinary neuropathological conditions in south africa (author's transl)]. | a brief review is given of some of the more recent findings on lesions of diseases affecting the central nervous system of animals. these include local diseases caused by poisonous plants; helichrysum argyrosphaerum, solanum kwebense, matricaria nigellaefolia; infectious diseases e.g. heartwater, cerebral babesiosis and cranial abscesses in goats caused by corynebacterium pyogenes. reference is also made to some conditions, originally described in overseas countries and which subsequently have b ... | 1977 | 327065 |
| corynebacterium pyogenes mastitis among heifer calves. | in august 1975 an outbreak of c pyogenes mastitis occurred involving 18 heifer calves at the national institute for research in dairying. this paper describes the outbreak which affected animals varying in age from five to 22 months. fourteen of the cases (77%) were among calves less than 10 months old. the advisability of using fly control measures among young stock in the summer months is discussed. | 1977 | 327674 |
| complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation. | a number of stimuli known to induce acid hydrolase secretion from cultured macrophages were examined for their ability to activate c3 via the alternative pathway of the complement system. loss of haemolytically active c3 was checked in normal and c4-deficient guinea-pig serum. for comparison the interactions of cultured macrophages with other agents well known as potent activators of the alternative pathway of the complement system have been investigated. as judged by their activity in these ass ... | 1977 | 328387 |
| adjuvant protection against bacterial infection in granulocytopenic mice. | the hypothesis that the induction of nonspecific resistance to infection by immunostimulation prior to drug-induced granulocytopenia would afford increased protection to subsequent bacterial challenge was tested in a murine model of infection with pseudomonas aeruginosa or staphylococcus aureus in mice rendered granulocytopenic with cyclophosphamide. prior intraperitoneal immunostimulation of mice with complete freund's adjuvant (cfa) or mycobacterium bovis (bacille calmette-guèrin; bcg) increas ... | 1977 | 328788 |
| lung abscess due to corynebacterium equi in a renal transplant recipient. | a case of corynebacterium equi infection in a renal transplant recipient is reported. this not uncommon pathogen of farm animals caused a lung abscess in a graft recipient who had received continuous immunosuppression with azathioprine and prednisone for seven years. antibiotic therapy yielded radiological improvement, although the patient died from other causes. c. equi joins a growing list of rare opportunistic organisms which may cause disease in subjects who have received transplants. | 1977 | 329078 |
| anaerobic and aerobic bacteriology in head and neck cancer surgery. | a prospective study of wound infections following major head and neck cancer surgery was undertaken to define a rational approach to trials of antibiotic prophylaxis and initial therapy of these infections. preoperative aerobic cultures were taken from the planned site of skin incision and from the oropharynx. both aerobic and anaerobic cultures were obtained from all wound infections. patients receiving prophylactic antibiotics were excluded from the study. the data indicate that preoperative c ... | 1977 | 329532 |
| imidazo[4,5-f]quinolines iii: antibacterial 7-methyl-9-(substituted arylamino)imidazo[4,5-f]quinolines. | a series of 7-methyl-9-(substituted arylamino)imidazo[4,5-f]quinolines was prepared and screened against four varieties of bacteria. the compounds possessed antibacterial activity against both gram-positive and gram-negative organisms. | 1977 | 330837 |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with corynebacterium parvum: reduced effect in irradiated recipients. | 1977 | 330869 | |
| [macrophage as a participant in resistance against malignant tumor]. | 1977 | 331002 | |
| [studies of immunity in mastitis in cows]. | studies were carried out to establish the specific antibodies in the milk and blood sera of cows recovered from a spontaneous infection of the udder caused by streptococci, staphylocci, corynebacteria, and some representatives of escherichia coli as well as of cows immunized with a polybacterial vaccine. followed up was likewise the resistance of the udder in vaccinated cows to bacterial infections. it was found that in both groups of animals the specific antibodies' titer ranged from 1:80 to 1: ... | 1977 | 331658 |
| [laboratory studies of the urine in suppurative surgical infection in cattle]. | one hundred and eight cattle (20 controls, 14 with an experimentally induced and 74 with spontaneously occurred suppurative surgery infection) were studied in terms of their general condition and some of the urine indices--ph, specific weight, proteins, urobillinogen, acetone, sugar, blood, urea and sediment. it was established that when the general status deteriorated and death occurred the urine ph value rose (by 1--1.5), and the specific weight was 0.005--0.010 higher, while the level of urin ... | 1977 | 331659 |
| [studies on the use of the se-(selective enterococcal) medium for routine diagnosis of enterococci]. | 1977 | 331699 | |
| [clinical results of two-time abortion technics with special regard to ascending genital infections]. | if risk of the one-time mechanical dilatation will be too high (with young first gravidae and progressed pregnancy) the methods of the two-time interruptio should be applied. as long as there will not be available sufficient quantities of prostaglandin-analoga the present method of choice is the abort-induction by means of the extra-amnial application of prostaglandin f2alpha. in 101 cases when extra-amnial pg f2alpha with an average induction time of four hours, the contamination rate was check ... | 1977 | 331753 |
| canine migration inhibitory factor: effect of corynebacterium parvum administration. | peripheral blood lymphocytes from dogs sensitized to streptolysin o (slo) were assayed for migration inhibitory factor (mif) production by the indirect mif test, using guinea pig peritoneal exudate cells as the source of macrophages. a specific direct correlation was established between the degree of inhibition of migration and the concentration of slo-stimulated supernatants from lymphocyte cultures (slo-s) of untreated normal dogs. undiluted slo-s inhibited migration by 66.8%, whereas a diluti ... | 1977 | 332636 |
| a double-blind comparative study of ampicillin, co-trimoxazole and josamycin in anthraco-silicotic miners, assessed by transtracheal puncture. | 1977 | 332681 | |
| corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse. | 1977 | 333124 | |
| corynebacterium vaginale. | corynebacterium vaginale is a sexually transmitted organism which was first recognized in 1953. it appears to utilize glycogen stored in vaginal epithelial cells, causing a malodorous vaginal discharge characterized by an abnormally high ph (5.0 to 5.5) and composed mainly of epithelial cells and hordes of bacilli. infected men are asymptomatic, carry the organism for an unknown period of time, and transmit it through intercourse. the organism requires five b-vitamins, purines, pyrimidines, and ... | 1977 | 333628 |
| bacterial phytotoxins. | representatives of all of the major genera of plant disease-causing bacteria have been shown to produce one or more phytotoxins. toxicological studies on the bacterial diseases of the major food crops have not been extensive. bacterial phytotoxins belong to a number of classes of organic substances, including peptide, derivatized amino acid, polysaccharide, and glycopeptide. the mechanism of action of these compounds is largely unknown, as is their origin and importance in the disease syndrome. ... | 1977 | 334039 |
| mechanism of corynebacterium parvum anti-tumour activity. ii. protective effect in t-cell-deprived mice. | the natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult c3h mice or in mice thymectomized, lethally irradiated and restored with bone-marrow cells (tx rb). the protective effect of c. parvum was not modified by adult thymectomy but it was reduced in tx rb mice. the injection of thymic cells to tx rb mice or the elimination of t cell precursors in bone-marrow cells injected in tx rb mice did not increase the protective effect of c. parvum. these results were ... | 1977 | 334678 |
| meatal recolonization in bitches. | 1977 | 335085 | |
| [the corynebacterium pyogenes infection in cattle. 1. incidence of the pathogen]. | reported are the incidence of corynebacterium pyogenes together with different pathological changes as well as the existence of latent corynebacterium pyogenes infections and their widespread occurrence. corynebacterium pyogenes was established from 609 in 2,130 samples of pathological processes, accounting for 28.6%. the pathogen was cultivated from various processes, including enlarged tail lymph nodes (61.1%), tail phlegmons (56.3%), abscesses (49.1%), epiphysiolyses (45.2%), liver abscesses ... | 1977 | 336000 |
| [the corynebacterium pyogenes infection of cattle. 2. tenacity of corynebacterium pyogenes]. | some common agents were tested for their effectiveness against corynebacterium pyogenes. the pathogen proved most susceptable to wofasteril. all germs were killed within ten minutes by a 0.005% solution. equally good action was recorded from all the other tested agents as well (lactic acid, lugol's solution, formalin, cupric sulphate, alcohol, and aethacridine. other studies were conducted with the view to testing the survival capacity of corynebacterium pyogenes in different media and storage c ... | 1977 | 336001 |
| the reversal of established enhancement in rat cardiac allografts. | established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent corynebacterium parvum proved ineffective. however, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four of a group of six as rats bearing enhanced (august x as)f1 hybrid heart allografts. a combination of c. ... | 1977 | 339437 |
| infection of the sheep headfly, hydrotaea irritans with bacterial isolates from field cases of summer mastitis. | 1977 | 339478 | |
| mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen. | peritoneal macrophages elicited in c3h/hj mice by the i.p. injection of corynebacterium parvum were cytotoxic to allogeneic virus-transformed fibroblasts in vitro. cytotoxicity was demonstrated in a morphologic (plaque) assay, and quantitated by measuring macrophage-mediated inhibition of incorporation of 3h-thymidine by the target cells. the cytotoxic effect was well established by 6 hr of macrophage-fibroblast interaction, and was retained in cultures from which the supernatant was removed bef ... | 1978 | 340584 |
| a randomized prospective evaluation of orally administered antibiotics in operations on the colon. | in this randomized, prospective study of 91 patients undergoing operations on the colon, we found that neomycin, neomycin-phthalylsulfathiazole and neomycin-erythromycin base all provided adequate intestinal antisepsis. wound infection rates for all groups were also similar and close to the national average for operations on the colon. a detailed analysis of the wound infections in our series revealed that 60 per cent of these infections were from organisms different from those found on the colo ... | 1978 | 341376 |
| mastitis and other diseases of the goat's udder. | udder problems of modern dairy goats are similar to those seen in dairy cows. anomalies of the goat's udder and teats are common, and many may be hereditary. skin diseases of the udder include viral infections, mange, sunburn, wounds, and staphylococcal dermatitis. there are numerous known causes of caprine mastitis. these include streptococci, hemolytic and nonhemolytic staphylococci, corynebacteria, and mycoplasmas. diagnosis of mastitis in goats is often difficult, as the udder secretion may ... | 1977 | 342465 |
| caseous lymphadenitis in goats and sheep: a review of diagnosis, pathogenesis, and immunity. | 1977 | 342466 | |
| suppression of natural killer cell cytotoxicity by splenocytes from corynebacterium parvum-injected, bone marrow-tolerant, and infant mice. | natural killer (nk) cell cytotoxicity to yac-1 lymphoma was investigated in mice tolerant to bone marrow grafts (bm-tolerant), corynebacterium parvum- (c. parvum) treated mice, and infant mice. also the comparison was made between the nk cell and the hemopoietic-resistance effector (hr-e) cells. it was found that the bm-tolerant mice and c. parvum-treated mice showed either no or markedly decreased nk cell cytotoxicity. these mice were also nonresponders to bone marrow grafts in vivo. the lack o ... | 1978 | 342602 |
| [clinical and experimental studies of suppurative surgical infection in cattle]. | investigated were a total of 30 cattle 6 of which had experimental surgery infection and 24 showed spontaneously developing suppurative infection. the animals were studied in terms of general status, blood picture, quality of urine and synovia, and rumen content. the dynamis was followed up of the development of sepsis and purulent artritis. it was found that in case of suppurative surgical infections in cattle the general status was invariably affected, the severity of the process depending on ... | 1977 | 343355 |
| [comparative studies on the etiology of subclinical mastitis in cows of different breeds on farms]. | 1977 | 343359 | |
| antitumor activity of corynebacterium parvum. | 1978 | 343523 | |
| the cells involved in the modification of the in vitro immune response by corynebacterium parvum (c. parvum). | 1977 | 344096 | |
| various modalities of local administration of bacterial immunostimulants in transplantable rat tumours and in primitive methylcholanthrene mouse tumours. | the frequent use of intra-lesional injection of bacterial immunostimulants is hampered by apparent rarity of susceptible tumours, absence of therapeutic effect on large tumours, lack of variety of experimental models, eventual traumatism which is feared in case of intra-lesional, and injection in visceral cancers. (1) methylcholanthrene induced primitive tumours in mice are more frequently susceptible when the carcinogen induction dosage is low (0.01 mg). (2) using transplantable rat tumours, on ... | 1977 | 344100 |
| a phase i study of a multi-modal schedule with corynebacterium parvum. | a phase i study of an immuno-chemotherapy regime was carried out using c. parvum as an immune-modulator. 14 women were studied. all received doses of c. parvum ranging from 2.5 mg to 21 mg administered in 1 litre of dextrose saline over 4 h. no evidence of tumour enhancement was observed. | 1977 | 344102 |
| clinical trial with corynebacterium parvum. | corynebacterium parvum was administered to sixteen patients with malignant tumors submitted to repeated chemotherapy courses. a total of 428 injections of c. parvum at a dose of 3.5 mg/m2 in weekly, biweekly and monthly administration was given between the chemotherapy courses. injection of c. parvum was followed by fever and local pain in 15/16 patients. three patients presented a local ulceration during the initial period of weekly injections. splenomegaly was observed after the second month o ... | 1977 | 344103 |
| clinical studies with corynebacterium parvum. | in a pilot study twelve patients with malignant disease were treated with corynebacterium parvum. the clinical results were encouraging. a prospective randomised controlled clinical trial of c. parvum therapy in the treatment of patients with carcinoma of the bronchus began in august 1976. 22 pateints have been admitted to the trial and 11 treated with c. parvum. clinical progress is reported. radiological, haematological, biochemical and immunological measurements have been made and these resul ... | 1977 | 344105 |
| randomized trial in advanced breast cancer using combination chemotherapy with or without c. parvum; preliminary results. | in a prospectively randomized cooperative study patients with metastatic breast cancer were treated with or without corynebacterium parvum (c.p.)5 mg/sc/m2 on day 1 in addition to cao/cmf (cyclophosphamid (c) 150 mg/m2/d per os x 5 d and adriamycine (a) 50 mg/m2 i.v. d 1 and oncovin (o) 1.0 mg/m2 i.v. d 1. 6 cao-cycles q 28 days later were followed by monthly cmf cycles q 28 d with cyclophosphamide (same dose), methotrexate 30 mg/m2 i.v. 1 and 5-fluorouracil 600 mg/m2 i.v. d 1). 76 patients ente ... | 1977 | 344108 |
| [experimental studies on the antimicrobial effect of several butylcyanoacrylate tissue adhesives]. | it is dealt with the effects of various butycyano-acrylate type surgical adhesives on gram-positive and gram-negative bacterial species. the experimental results show a growth-inhibiting effect on gram-positive germs. gram-negative germs are not affected. the growth inhibition produced by so2-containing adhesives is greater than that caused by so2-free ones. as compared to histoacryl blue, the fimomed variants showed a broader spectrum. furthermore, it was stated that the adhesive exerts its gro ... | 1978 | 347732 |
| corynebacterium pyogenes septic arthritis with plasma cell synovial infiltrate and monoclonal gammopathy. | a chronic septic process developed in the right knee of an elderly man with advanced degenerative arthritis of both knees. open exploration, culture, and biopsy of the joint found that the pathogen was corynebacterium pyogenes and that the synovium was involved with a remarkable perivascular infiltrate of plasma cells. serum protein electrophoresis demonstrated a prominent m component. following antimicrobial therapy, the m protein level has gradually declined, and no evolution of multiple myelo ... | 1978 | 348137 |
| failure to induce in rabbits effective immunity to a mixed infection of fusobacterium necrophorum and corynebacterium pyogenes with a combined bacterin. | failure to induce in rabbits effective immunity to a mixed infection of fusobacterium necrophorum and corynebacterium pyogenes with a combined bacterin. onderstepoort journal of veterinary research, 44 (4), 253--2;6 (1977). rabbits were immunized with alum-precipitated, oil adjuvant and an untreated bacterin composed of f. necrophorum and c. pyogenes. immunized rabbits were challenged intradermally with a mixture of f. necrophorum and c. pyrogenes. immunized rabbits were challenged intradermally ... | 1977 | 349444 |
| combination chemotherapy plus methanol extracted residue of bacillus calmette-guérin or corynebacterium parvum in stage iii lung cancer. | seventy-six patients with stage iii bronchogenic carcinoma were treated with monthly adriamycin, cyclophosphamide, cis-dichlorodiammineplatinum(ii), and vincristine. in addition, they were randomized to receive either no immunotherapy, the methanol extracted residue of bacillus calmette-guérin (mer), or corynebacterium parvum (c. parvum). age, histology, extent of disease, prior therapy, and performance status were comparable in the three treatment groups. twelve patients (16%) died having recei ... | 1978 | 350388 |
| chemo-immunotherapy for unresectable bronchogenic carcinoma. | seventy-nine patients with metastatic or unresectable bronchogenic carcinoma were treated with a regimen of combination chemotherapy which included methotrexate, oncovin (vincristine), cyclophosphamide, and adriamycin (moca), and were randomized to receive no additional therapy, immunotherapy with bacillus calmette-guérin, or immunotherapy with corynebacterium parvum (c. parvum). the response rate and estimated median survival time were 68% and 42 weeks in small cell carcinoma and 18% and 29 wee ... | 1978 | 350397 |
| bacteriological examination of summermastitis secretions. the demonstration of bacteroidaceae. | corynebacterium pyogenes was isolated from 22, peptococcus indolicus from 22, a microaerophilic coccus from 21, bacteroides melaninogenicus subsp. melaninogenicus from 18, fusobacterium necrophorum from 15, and various unidentified anaerobes from 9 of a total of 22 summermastitis secretions examined. | 1978 | 351551 |
| isolation of ureaplasma from bovine granular vulvitis. | cultures for mycoplasmatales, viruses and bacteria were made from bovine vulvar swabs to determine whether ureaplasma was associated with a clinical granular vulvitis observed in 16 ontario dairy herds. ureaplasma was isolated from 23.5% of 34 clinically normal cows, 74% of 27 cows with mild to moderate vulvar hyperemia but no discharge and 100% of 20 cows with acute vulvar hyperemia accompanied by purulent discharge. there were statistically significant differences in rates of isolation among c ... | 1978 | 352491 |
| nonspecific immunostimulant activities of synthetic trehalose-6,6'-diesters (lower homologs of cord factor). | mycobacterial cord factors (6,6'-diesters of trehalose with mycolic acids ranging from c80 to c90) have been shown to protect mice effectively against infection with klebsiella pneumoniae or with listeria monocytogenes. our present findings indicate that the low-molecular-weight cord factor of corynebacterium diphtheriae (with corynomycolic acids ranging from c28 pto c36) is equally active. moreover, its synthetic analog (with synthetic c32 mycolic acid) has the same activity. two lower syntheti ... | 1978 | 352926 |
| combination chemoimmunotherapy for extensive non-oat cell lung cancer. | in a prospective randomized trial, sc corynebacterium parvum (c. parvum) immunotherapy did not significantly affect the responses and survival of 49 non-oat cell lung cancer patients receiving isophosphamide and adriamycin chemotherapy. remissions (tumor regression greater than 50%) were seen in five of 23 patients receiving an intensive c. parvum schedule and in three of 26 patients receiving a nonintensive c. parvum schedule (22% versus 12%). median survival was 20 weeks for patients given int ... | 1978 | 356968 |
| increase in the population of duodenal immunoglobulin a plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin. | various bacterial strains were tested for their ability to stimulate immunoglobulin a (iga) plasmocytes to populate the duodenal lamina propria in axenic mice. the mice were associated with the strains for at least 4 weeks. the strains inhabiting the conventional mouse intestine and belonging to the genera lactobacillus, streptococcus, eubacterium, actinobacillus, micrococcus, corynebacterium, and clostridium (including the extremely oxygen-sensitive ones) are only slightly or nonimmunogenic, wh ... | 1978 | 357289 |
| a diagnostic key employing biological reactions for differentiating pathogenic corynebacterium genitalium (nsu corynebacteria) from commensals of the urogenital tract. | more than 100 strains of corynebacterium genitalium, probably responsible for coryneform urethritis and other infections, and 600 commensals of the male and female urogenital tracts have been studied and grouped into five pathogenic types numbered i to v and six saprophytic types designated c-1 to c-6 on the basis of eight biological reactions. this preliminary classification has been based on differences in requirements for oxygen, on the fermentation of fructose, dextrose, sucrose, and starch ... | 1978 | 357342 |
| immune interferon. ii. different cellular site for the production of murine macrophage migration inhibitory factor and interferon. | the production of macrophage migration inhibitory factor (mif) and immune interferon (if) by concanavalin a (con a)-stimulated cultures of thymus, lymph node and spleen cells was investigated. it was found that all cultures produced mif activity, whereas only spleen cells produced marked if activity. the capacity to produce if was found to be correlated with the macrophage content of a cell preparation as evidenced by staining for esterase-positive cells. furthermore, column-purified spleen t ce ... | 1978 | 359337 |
| the effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response. | bacillus calmette-guerín (bcg), corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. c. parvum and methanol extracted residue of bcg elicited significant immunostimulation without producing irreversible bladder damage. the severe histologic disruption caused by bcg could be reduced by the antituberculus drug isoniazed without abrogating the humoral s ... | 1978 | 361626 |
| corynebacterium pyogenes endocarditis. report of a case with necropsy and review of the literature. | 1978 | 361919 | |
| [immuno-chemotherapy in patients with disseminated metastasizing stage iii melanoma. randomized study with methyl-ccnu versus c. parvum plus methyl-ccnu]. | 34 patients with disseminated malignant melanoma (stage iii) were randomized to the following therapy groups: chemotherapy (meccnu, nsc 99441; 200 mg/m2, given orally every 8 weeks), or immuno-chemotherapy (1 mg corynebacterium parvum i.v., on days 1-4 + meccnu 200 mg/m2 on day 8, repeated every 7 weeks). total therapy response rate was 33%; total and partial remissions were achieved in 26% of the patients receiving chemotherapy, and in 40% under immuno-chemotherapy. interim life table analysis ... | 1978 | 362293 |
| immunomodulation by corynebacterium parvum. 1. variable effects on anti-sheep erythrocyte antibody responses. | corynebacterium parvum injected i.p. 1--16 days prior to i.p. antigen inoculation virtually abolished both igm and igg primary responses to 1 x 10(8) srbc. the suppression was significantly marked at antigen doses ranging from 1 x 10(6)--1 x 10(9) srbc but not at 5 x 10(9) srbc. as little as 56 microgram c. parvum caused a marked suppression of the response to 1 x 10(8) srbc. in secondary responses c. parvum given either one day before priming with 1 x 10(8) srbc or one day before secondary chal ... | 1978 | 363603 |
| cervical-vaginal flora of women with invasive cervical cancer. | the cervical-vaginal flora of 21 women with invasive cervical cancer was determined. the cultures yielded polymicrobial growth with anaerobic organisms predominating. as compared with other studies of vaginal flora, the cancer patients were found to have a decreased frequency of isolation of aerobic lactobacilli, staphylococcus epidermidis, and enterococci, and an increased frequency of isolation of escherichia coli and bacteriodes species. the composition of the anaerobic vaginal flora in these ... | 1978 | 364358 |
| preliminary report of the use of levamisole in the treatment of bladder cancer. | sixty-two patients with transitional cell carcinoma have been admitted to a double-blind randomized control study with levamisole as an immune adjuvant, in addition to standard therapy for noninvasive and invasive bladder cancer. levamisole has been shown to be easily administered and is well-tolerated, especially when compared to other immune adjuvants such as bacillus calmette-guerin or corynebacterium parvum. to date, there is no significant difference in the disease-free interval in the leva ... | 1978 | 365325 |
| host defenses in murine malaria: induction of a protracted state of immunity with a formalin-killed plasmodium berghei blood parasite vaccine. | random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of plasmodium berghei, strain nyu-2, in combination with corynebacterium parvum and/or living bcg. a high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. vaccinated mice developed a patent infection after challenge similar to that observed in normal controls. however, between days 12 to 20 postchallenge, infections in some vaccinated mi ... | 1978 | 365770 |
| the capsules of corynebacterium equi and streptococcus equi. | the capsules of corynebacterium equi and streptococcus equi were examined by electron microscopy after staining with ruthenium red. they were compared with the capsule of klebsiella pneumoniae which had previously been examined using the same procedure (springer & roth, 1973). the capsule of c. equi had a laminated appearance. when s. equi was grown on solid medium, its capsule appeared as radially arranged projections capped by a thick electron dense layer. when grown in liquid medium, s. equi ... | 1978 | 366078 |
| [studies on the exotoxin of corynebacterium pyogenes following purification using gel filtration and deae ion exchanger]. | 1978 | 367011 | |
| specific immunofluorescence of corynebacterium renale. | 1979 | 367528 | |
| [fibrous suppurative arthritis in sheep]. | described are cases of fibrinous supprative arthritis in sheep characterized by thickenning of the joint, resulting from the involvement of the capsule (periarthritis). histopathologically, there have been suppurative and necrotic processes combined with fibrinoid necrotizing of the collagen fibers and leukocyte infiltration of the joint capsule. slight leukocyte infiltration has also been said to occur in the parenchymal organs. microbiologic studies have revealed the presence of pyogenous bact ... | 1978 | 369111 |