| corynebacterium aquaticum urinary tract infection in a neonate, and concepts regarding the role of the organism as a neonatal pathogen. | corynebacterium aquaticum urinary tract infection developed in a neonate 8 days after uncomplicated vaginal delivery. prior to definitive identification, the isolate was thought to be listeria monocytogenes because of its microscopic morphology, catalase positivity, and tumbling motility. the infant responded to intravenous ceftriaxone. because the presentation of c. aquaticum in this patient suggested systemic involvement, c. aquaticum may be regarded as a bona fide neonatal pathogen. | 1989 | 2915029 |
| amnionitis and life-threatening respiratory distress after percutaneous umbilical blood sampling. | although amnionitis secondary to percutaneous umbilical blood sampling is extremely uncommon, a high index of suspicion should be maintained and a full evaluation should be initiated if nonspecific signs of infection appear within 2 weeks after the procedure is performed. in this case life-threatening adult respiratory distress syndrome was a sequela of this complication. | 1989 | 2916631 |
| purification, characterization and revised amino acid sequence of a second thioredoxin from corynebacterium nephridii. | a second thioredoxin, distinct from the one reported by meng and hogenkamp in 1981 (j. biol. chem. 256, 9174-9182), has been purified to homogeneity from an escherichia coli strain containing a plasmid encoding a corynebacterium nephridii thioredoxin. thioredoxin genes from c. nephridii were cloned into the plasmid puc13 and transformants were identified by complementation of a thioredoxin negative (trxa-) e. coli strain. the abilities of the transformants to support the growth of several phages ... | 1989 | 2917572 |
| [serious infections in alcoholics. 2. etiology of bacteremia and meningitis in alcoholics discharged from hospitals in funen 1981, 1984 and 1986]. | in 1981, 1984 and 1986 relatively more episodes of bacteremia with corynebacterium in one or two tubes out of twelve were found in alcoholics and these normally negligible episodes may be a iatrogenic marker of intubation and esophagoscopy in alcoholics. definite bacteremic episodes with e. coli, staphylococcus aureus, klebsiella, streptococcus pneumoniae, proteus, pseudomonas aeruginosa, enterobacter, streptococcus faecalis, haemolytic streptococcus and bacteroides were found in 0.79% of alcoho ... | 1989 | 2919457 |
| modulation of hematoporphyrin derivative-sensitized phototherapy with corynebacterium parvum in murine transitional cell carcinoma. | the interaction of photodynamic therapy (pdt) with hematoporphyrin derivative (hpd) and immunotherapy with corynebacterium parvum (cp) was studied in a murine transitional cell carcinoma (mbt-2) model. c3h/he mice were transplanted subcutaneously in the hind limb with 2.5 x 10(5) tumor cells. one day after transplantation, mice were randomized into groups to receive saline (control), pdt, cp 25 micrograms, cp 250 micrograms, cp 25 micrograms + pdt, and cp 250 micrograms + pdt. pdt was administer ... | 1989 | 2919485 |
| a retrospective study of hepatic abscesses in goats: pathological and microbiological findings. | post-mortem examination of 658 goats showed that 17 (2.5%) exhibited hepatic abscesses. the following bacteria were isolated: corynebacterium pseudotuberculosis (58.9%), escherichia coli (11.8%), corynebacterium sp. (11.8%), pasteurella haemolytica (5.9%), proteus sp. (5.9%) and staphylococcus aureus (5.9%). hepatic abscesses occurred more frequently in adult animals. eleven of the 17 goats (64.7%) were older than 12 months of age. four goats (23.5%) were 12 months of age and only two (11.8%) we ... | 1989 | 2920279 |
| development of antitumor reactivity in regional draining lymph nodes from tumor-immunized and tumor-bearing murine hosts. | with use of the weakly immunogenic mca 105 tumor of the c57bl/6 mouse, the antitumor reactivity of lymphoid cells derived from the regional draining lymph nodes (rln) of tumor-immunized and tumor-bearing mice was examined. mice were immunized with an inoculation of viable tumor admixed with corynebacterium parvum. excision of tumor immunization sites within 4 days abrogated the development of systemic immunity to reject a tumor challenge. however, excision of the immunization site on day 6 did n ... | 1989 | 2928954 |
| corynebacterium pseudotuberculosis: biochemical properties, production of toxin and virulence of ovine and caprine strains. | twenty-two strains of corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis, were isolated from typical abscesses in sheep and goats from flocks in 6 different regions of france and were characterized. these strains were uniform in biochemical characteristics, susceptibility to 8 antimicrobial agents, and virulence for of1 mice. all these strains produced an exotoxin, identified by inhibition of staphylococcal beta-hemolysin. moreover, this study showed that strain 19r ... | 1989 | 2930134 |
| the effect of bone marrow depletion on prostaglandin e-producing suppressor macrophages in mouse spleen. | the i.p. injection of corynebacterium parvum (cp) into cba/j mice effected increases in macrophage colony-forming cells (m-cfc) when spleen cells were cultured with l cell culture filtrate as a source of colony-stimulating factor. significant increases in phagocytic macrophages (m phi) with fc receptors for igg2a and igg2b immune complexes were additionally noted among the spleen cells in these mice. these m phi effectively inhibited con a-induced lymphocyte proliferation, probably reflecting a ... | 1985 | 2933455 |
| suppression of murine nk activity induced by corynebacterium parvum: further characterization and abrogation of suppressor cells. | formalin-killed corynebacterium parvum (cp), given at a dose of 0.4-0.7 mg/mouse iv or ip, induced suppressor cells for nk activity in b6c3f1 mice. the suppressor cells belong to at least two different populations, plastic adherent and nonadherent, and were not depleted by antibodies specific for thy-1.2, iak, or nk-1.2 surface markers. administration of p-i:c, an interferon-inducer, to animals 18 h before the assay did not affect the suppressor activity. hypotonic shock treatment of splenocytes ... | 1986 | 2935247 |
| tumor-specific suppressor t-cells which inhibit the in vitro generation of cytolytic t-cells from immune and early tumor-bearing host spleens. | spleen cells from dba/2 mice, after immunization with syngeneic p815 mastocytoma cells and corynebacterium parvum, respond to p815 in vitro with a brisk, secondary-type generation of cytotoxic cells. this cytotoxicity is mediated by antigen-specific t-lymphocytes and correlates with resistance to in vivo challenge. this model confirms the observations of previous investigators made in semisyngeneic hosts using an in vivo transfer model. spleen cells from "early" tumor-bearing hosts (tbhs), 7-12 ... | 1986 | 2936451 |
| evaluation of teicoplanin and vancomycin disk susceptibility tests. | disk tests with two glycopeptide antibiotics, teicoplanin and vancomycin, were evaluated, and mics were compared with those of fusidic acid and coumermycin. for tests with 30-micrograms vancomycin disks, we recommend modification of the current zone size standards to less than or equal to 10 mm for resistant and greater than or equal 15 mm for susceptible. for teicoplanin disk tests, 30-micrograms disks are recommended, with zone size interpretive standards of less than or equal to 10 and greate ... | 1986 | 2939101 |
| differences in the effects of host suppression on the adoptive immunotherapy of subcutaneous and visceral tumors. | a syngeneic transplantable sarcoma induced in c57bl/6 mice, mca 105, was used in studies to examine host suppression on the adoptive immunotherapy of established intradermal and experimentally induced pulmonary and hepatic metastases. fresh immune splenocytes were generated from mice immunized to the mca 105 tumor by a mixture of viable tumor cells and corynebacterium parvum. the adoptive immunotherapy of intradermal mca 105 tumor with immune cells required prior immunosuppression of the recipie ... | 1986 | 2939946 |
| splenocytes from tumor-bearing corynebacterium parvum treated mice maintain interleukin-2 and -3 activity. | systemic and local administration of the bacterium corynebacterium parvum (more accurately known as propionibacterium acnes) is reported to exert antitumor action via activated macrophages or short-lived cytotoxic t lymphocytes (ctl), respectively. this study examined the effect of c. parvum treatment on resulting in vitro interleukin levels, which are components in the sequence of events leading to the development of effective ctl. c. parvum administration prevented palpable fibrosarcoma develo ... | 1986 | 2939948 |
| reaction of the thymus and the bursa of fabricius in chickens inoculated with corynebacterium parvum. | | 1985 | 2940837 |
| [evaluation of the immunological effectiveness of the planned vaccinal prophylaxis of diphtheria and tetanus in sverdlovsk and sverdlovsk province]. | the level and intensity of antitoxic immunity to diphtheria and tetanus in children and adolescents were determined. the presence of tetanus antitoxin in titers exceeding the protective level in 96.3-98.5% of the examined children and adolescents is indicative of a high actual coverage by immunization. protective titers against diphtheria were lower. there was no essential difference in the levels of protection in children immunized according to the vaccination schedule and in those immunized wi ... | 1986 | 2944328 |
| [immunological structure of the population in a system of epidemiological surveillance of diphtheria]. | the characteristics of antitetanus and antidiphtheria immunity in children, adolescents and adults in perm have been determined by means of the passive hemagglutination test, and the tendency towards the decrease of their immunity to diphtheria with the increase of their age has been established. the registered and actual coverage of children and adolescents by immunization is characterized on the basis of the presence of antibodies to the tetanus component of combined vaccines. a considerable p ... | 1986 | 2944332 |
| microbial pathogens from goat mastitis and phage-typing of staphylococcus aureus isolates. | examination of milk from goats yielded 41 strains from 40 clinically affected halves; 15 were staphylococcus aureus, 6 staph. epidermis, 1 streptococcus agalactiae, 2 strept. dysgalactiae, 5 strept. uberis, 2 corynebacterium pyogenes, 3 escherichia coli, 3 pasteurella spp. and 4 mycoplasma spp. one half had dual infection of staph. aureus and strept. dysgalactiae. twenty two of the 297 milk samples from apparently normal halves also harboured pathogens comprising of 9 staph. aureus, 1 strept. ag ... | 1986 | 2945693 |
| [the main trends in a diphtheria epidemic process and the potentials for its elimination in a large city]. | in recent years the tendency towards the activation of the epidemic process of diphtheria, i.e. the appearance of cases of diphtheria simultaneously with the increased levels of circulation of toxigenic and nontoxigenic corynebacterium diphtheriae and with antitoxic immunity characteristics in children and adults constantly remaining low, has been registered. for the effective control of diphtheria, the profound study of such problems as bacterial carriership, antibacterial immunity and the deve ... | 1986 | 2948351 |
| effect of some new crown ethers on plant-related bacteria and their possible mode of action. | | 1986 | 2949476 |
| antigen-specific suppression of the in vitro cytotoxic response by a soluble factor produced by corynebacterium parvum-induced allospecific suppressor cells. | the adjuvant corynebacterium parvum, when administered intravenously during an ongoing alloimmunization, induces alloantigen-specific splenic suppressor cells which inhibit primary and secondary in vitro sensitizations. we have previously shown that these cells produce a soluble suppressor factor in culture. we now further characterize this factor and its mechanism of action. release of this suppressive factor is dependent upon specific restimulation of the splenic suppressor cell with the sensi ... | 1987 | 2949854 |
| subtherapeutic numbers of tumour-sensitized, l3t4+, ly 1+2- t cells are needed for endotoxin to cause regression of an established immunogenic tumour. | the immunological requirements for endotoxin-induced regression of an established subcutaneous tumour (sa 1 sarcoma) were investigated by employing tumour-bearing t-cell deficient mice as test recipients, and mice generating concomitant immunity, or corynebacterium parvum-augmented concomitant immunity, as donors of sensitized t cells. it was found that endotoxin failed to cause regression of an established tumour in t-cell deficient recipients unless they were infused 2 days earlier with a subt ... | 1987 | 2952585 |
| comparative functional analysis of helper t lymphocyte responses to soluble and particulate antigens. | an adaptable and sensitive assay to analyze the roles of helper t lymphocytes (th) which recognize soluble or cell-surface bound antigens in the induction of cytotoxic t lymphocyte precursors (ctlp) is described. long-term t cell lines that recognize purified protein derivative, keyhole limpet hemocyanin, or corynebacterium parvum were used in these studies. the ability of t cells from these lines to induce cytotoxic t lymphocyte or antibody responses were compared with their ability to prolifer ... | 1987 | 2952708 |
| [dynamics of diphtheria morbidity and population immunity]. | observations on the stratum immune to diphtheria among the population, carried out over a period of many years and involving more than 37,000 people, have shown its gradual decrease in all adult age groups. in recent years the number of adults susceptible to diphtheria exceeded the number of susceptible children by 10.6%, and in some age groups by 18.5-21.8%, which makes for the total increase of diphtheria morbidity in recent years owing to its rise among adults. regular revaccination of the ad ... | 1987 | 2953152 |
| desensitization of macrophage oxygen metabolism on immobilized ligands: different effect of immunoglobulin g and complement. | during adhesion and spreading to immobilized immune complexes, casein-elicited mouse peritoneal macrophages produced superoxide anion. this production was time-dependent, ceased after a couple of hours, and was due to interaction with immunoglobulins g (igg) because neither immobilized antigen alone nor immunoglobulins m with or without complement-derived fragments were efficient stimuli. cultivation of macrophages on immobilized igg for 24 hr caused desensitization of the response to an unrelat ... | 1987 | 2953806 |
| [epidemiological and immunological assessment of a schedule of prophylactic inoculations]. | the epidemiological and immunological evaluation of two immunization schedules approved by the orders of the ussr ministry of health no. 322 of april 24, 1973, and no. 50 of january 14, 1980, has been made on the basis of the results obtained in the brest region of the byelorussian ssr and in the turkmen ssr. according to these results, the use of the schedule approved by order no. 50 has made it possible to increase the groups of children receiving correct and timely immunization with measles v ... | 1987 | 2954343 |
| functional differences and complementation between dendritic cells and macrophages in t-cell activation. | functional differences and cell collaboration between murine lymphoid dendritic cells (dc) and macrophages (m phi) in antigen presentation for t-cell activation were analysed with splenic dc and m phi, culture-derived bone-marrow (bm)-m phi, and dc-like and m phi-like cell lines. dc were the best stimulators of allogeneic mixed leucocyte reaction (mlr), but splenic m phi and small activated bm-m phi were almost as effective. in contrast to mlr stimulation, small activated bm-m phi were the most ... | 1987 | 2956179 |
| bactericidal activity and killing rate of serum in volunteers receiving vancomycin or teicoplanin with and without amikacin given intravenously. | we have studied the interaction between vancomycin or teicoplanin and amikacin in two groups of five volunteers randomized to receive either (a) vacomycin, amikacin, vancomycin+amikacin, or (b) teicoplanin, amikacin, teicoplanin+amikacin. each administration was given on separate days, in random order with a 48 hours washout period between each infusion. the serum concentrations measured microbiologically at time 0, 1 and 6 h were: 42.6, 11.4 and 4.1 mg/l respectively for teicoplanin; 27.6, 13.9 ... | 1987 | 2956228 |
| cellular interactions and the role of interleukin 2 in the expression and induction of immunity against a syngeneic murine sarcoma. | we have previously demonstrated that following the adoptive transfer of immune cells, the regression of established pulmonary metastases from a weakly immunogenic sarcoma, mca 105, required the collaboration of two t cell subsets. in this study, we found that the critical role played by l3t4+ immune cells was to provide a helper function since tumor regression proceeded in the absence of l3t4+ immune cells if exogenous interleukin 2 (il-2) was administered. to extend these observations, we analy ... | 1987 | 2957448 |
| [comparative double-blind study of topical clindamycin phosphate and oral tetracycline in the treatment of acne]. | | 1987 | 2959827 |
| [epidemiological surveillance of diphtheria infection in the territory of the azerbaijan ssr]. | a complex of measures carried out with a view of effecting the epidemiological surveillance of diphtheria infection has made it possible to study the level and intensity of immunity to diphtheria and tetanus, determined in the passive hemagglutination test, in the child and adult population and to reveal groups, least protected against diphtheria infection. bacteriological studies on the biological properties of corynebacterium diphtheriae have revealed the contamination of various groups of chi ... | 1988 | 2966528 |
| naturally occurring subclinical corynebacterium kutscheri infection in laboratory rats: strain and age related antibody response. | naturally occurring subclinical corynebacterium kutscheri infection was analyzed by antibody response related to the strain of rats. wistar-lewis, wistar and spraque-dawley rats were high responders in seroconversion rates and antibody titers, while brown norway and fischer rats were low responders. the antibody response was related to age also. some young rats had maternal antibody to c. kutscheri, but antibody disappeared before 8 weeks of age. rats were antibody-negative for several months th ... | 1988 | 2966878 |
| synergistic activity between vancomycin or teicoplanin and gentamicin or tobramycin against pathogenic diphtheroids. | the in vitro activities of vancomycin and teicoplanin alone and in combination with gentamicin or tobramycin were studied by time-kill techniques with 11 strains of pathogenic diphtheroids (corynebacterium group jk). the activities of vancomycin and teicoplanin were similar (mic for 90% of strains tested [mic90], 1 microgram/ml), as were those of gentamicin and tobramycin (the mic90 was 1 microgram/ml for five aminoglycoside-susceptible strains, and the mic90 was greater than 1,024 micrograms/ml ... | 1988 | 2967670 |
| efficacy of teicoplanin as antimicrobial treatment of severe nosocomial infections caused by gram-positive bacteria: a preliminary study. | we used single daily intravenous teicoplanin as therapy for 12 severe nosocomial infections caused by gram-positive bacteria. a daily dosage of 3-6 mg/kg was usually adopted; however, in selected cases the dosage was increased to 8-9.5 mg/day on the basis of serum bactericidal monitoring. most of these infections were life-threatening and included ventriculitis/meningitis (3 cases), sepsis (3 cases), mediastinitis (1 case) and extensive burn wound infection (1 case). staphylococcus aureus was by ... | 1988 | 2969302 |
| [treatment of erythrasma with 1% bifonazole cream]. | | 1987 | 2972471 |
| immunophenotype of pulmonary cellular infiltrates in sheep with visceral caseous lymphadenitis. | pulmonary lesions associated with corynebacterium ovis were analyzed with an indirect immunoperoxidase staining technique using monoclonal antibodies. the predominant cells in abscess walls and surrounding lung parenchyma were large macrophages which expressed major histocompatibility complex (mhc) class ii molecules on their surfaces. t lymphocytes were prominent in the same sites in the naturally occurring lesions, and sbu-t4-positive ("helper/inducer") cells were the major subset of lymphocyt ... | 1988 | 2976546 |
| teicoplanin: an investigational glycopeptide antibiotic. | the chemistry, mechanism of action, antimicrobial spectrum, pharmacokinetics, adverse effects, and clinical uses of teicoplanin are reviewed. teicoplanin, a novel glycopeptide that is similar to vancomycin, was isolated in the mid-1970s. a fermentation product of actinoplanes teicomyceticus, teicoplanin is a structurally complex compound made up of six fatty-acid components attached to a common aglycone. teicoplanin's mechanism of action, like that of vancomycin, is inhibition of cell-wall biosy ... | 1988 | 2977108 |
| [incidence of diphtheria (data of the results of the bacteriologic examination of patients with tonsillitis)]. | | 1988 | 2977231 |
| activation of mouse macrophages causes no change in expression and function of phorbol diesters' receptors, but is accompanied by alterations in the activity and kinetic parameters of nadph oxidase. | mouse peritoneal macrophages activated in vivo by the injection of corynebacterium parvum release larger amounts of superoxide anion (o2-) than macrophages from control mice when stimulated with phorbol myristate acetate (pma). the biochemical bases for this enhanced response of activated macrophages have been investigated by studying the expression and function of receptors for the stimulant, and the activity of the enzyme nadph oxidase which is responsible for the production of o2- in leucocyt ... | 1985 | 2981767 |
| new bacteriophage-like particles in corynebacterium glutamicum. | three new phage-like particles (cg1, cg2, and cgk1) were isolated from corynebacterium glutamicum cbii. particles cg1 and cg2 are dna phages with long, noncontractile tails, cgk1 is a killer particle according to electron microscopy. a heat-stable low-molecular-weight bacteriocidal substance affecting various coryneform bacteria was observed to be joined to the killer particle cgk1. | 1985 | 2982237 |
| detection and physical map of a omega tox+-related defective prophage in corynebacterium diphtheriae belfanti 1030(-)tox-. | a library of chromosomal dna from corynebacterium diphtheriae belfanti 1030(-)tox- was cloned in the lambda phage vector embl4 and screened for sequences homologous to corynephage omega tox+ and the attb1-attb2 region of the c7(-)tox- chromosome. two portions of the 1030(-)tox- chromosome, 35 and 30.5 kilobases long which contain, respectively, the entire region homologous to corynephage omega tox+ and the attb1-attb2 sites, were mapped with the restriction endonucleases bamhi and ecori. chromos ... | 1985 | 2983113 |
| in situ activation of murine peritoneal macrophages by cyclohexyl-1,3-dioxepin and 4-methyl-2-pentenoyl maleic anhydride copolymers. | peritoneal macrophages (pm theta) from mice treated intraperitoneally with the unique polyanionic compounds cyclohexyl-1,3-dioxepin maleic anhydride copolymer (cda-ma) and 4-methyl-2-pentenoyl maleic anhydride copolymer (mp-ma) had tumoricidal activity against lewis lung tumor cells. 5'-nucleotidase ectoenzyme activity, which had previously been associated only with nontumoricidal, resident pm theta, was elevated in tumoricidal pm theta elicited with cda-ma and mp-ma. cell counts and differentia ... | 1985 | 2984339 |
| increased release of hydrogen peroxide and superoxide anion from asbestos-primed macrophages. effect of hydrogen peroxide on the functional activity of alpha 1-protease inhibitor. | the ability of asbestos-elicited murine peritoneal macrophages to release superoxide anion and hydrogen peroxide, following in vitro triggering, has been investigated. the asbestos-elicited macrophages produced increased levels of superoxide and hydrogen peroxide compared to control macrophages and similar levels to those produced by corynebacterium parvum elicited macrophages. the supernatants from asbestos-elicited macrophages which had been triggered in vitro were capable of impairing the abi ... | 1985 | 2989174 |
| use of a self-generating percoll gradient and single cell cytotoxicity assay to identify tumor-lytic properties of inflammatory neutrophils. | within a murine model of regional immunotherapy, the cytolytic potential of peritoneal neutrophils could not be confirmed or quantified using routine techniques of cell separation and chromium release assays. we, therefore, developed procedures for the enrichment of neutrophils and estimation of the frequency of killer cells. peritoneal exudate cells from mice injected with corynebacterium parvum were fractionated on a self-generating percoll gradient to enrich for neutrophils and deplete macrop ... | 1985 | 2991386 |
| intraperitoneal immunotherapy of epithelial ovarian carcinoma with corynebacterium parvum. | corynebacterium parvum was administered intraperitoneally to 21 patients with epithelial ovarian cancer. nineteen patients had surgically measurable disease and two received adjuvant therapy. surgically confirmed responses were documented in six of 19 patients (31.6%), with two complete responses (10.5%) and four partial responses (21.1%). three patients (15.8%) had stable disease, and 10 patients (52.6%) had disease progression. the mean survival of the patients who had a complete response was ... | 1985 | 2992276 |
| dna relationships among some tox-bearing corynebacteriophages. | the dna genomes of a number of tox-bearing, temperate corynebacteriophages isolated from strains of corynebacterium diphtheriae and corynebacterium ulcerans were compared. with one exception, these phages displayed similarities in their restriction enzyme digest profiles and extensive homology with prototypic beta converting phage. the exception, phage delta, had a unique restriction profile and exhibited homology with beta over a limited portion of its genome. dnas of phages from each host cont ... | 1985 | 2993167 |
| chemical preparation of the eye in ophthalmic surgery. iv. comparison of povidone-iodine on the conjunctiva with a prophylactic antibiotic. | we previously found that half-strength (5%) povidone-iodine solution significantly reduced the bacterial flora of the conjunctiva. to compare the antibacterial effect of a topical combination antibiotic (neosporin ophthalmic solution) given three times daily for three days preoperatively with that of half-strength povidone-iodine solution given as part of the preoperative preparation, conjunctival cultures were studied from 35 patients undergoing ocular surgery. when used individually, the antib ... | 1985 | 2994609 |
| oxygen-derived free radicals promote hepatic injury in the rat. | we have investigated the possible protective effect of superoxide dismutase and allopurinol in a rat model of mild and severe hepatic necrosis produced by corynebacterium parvum with or without endotoxin. histology showed a sinusoidal mononuclear cell infiltrate with multiple granulomata but variable degrees of hepatic necrosis. in the severe hepatic injury model there was a reduction in mortality, associated with a decrease in histologic and biochemical evidence of hepatic necrosis, after treat ... | 1985 | 2995189 |
| the restoration of impaired macrophage functions using as immunomodulator the corynebacterium granulosum-derived p40 fraction. | many microorganisms and compounds of microbial origin exhibit immunomodulatory activities and have been extensively used in immunotherapy of experimental animal tumors and in patients with neoplasia. in this paper we describe the effect of the c. granulosum-derived p40 fraction on the growth and metastatization of the transplantable epithelioma t8 of guèrin. moreover, we evaluated the effect of p40 treatment on several depressed macrophage functions of tumor-bearing rats. in particular, the phag ... | 1985 | 2997082 |
| cytochemical study of macrophage lysosomal inorganic trimetaphosphatase and acid phosphatase. | cytochemical investigations have associated acid inorganic trimetaphosphatase (tmpase) activity with the lysosomes of certain cell types. we have used the modified staining technique of berg to show that this enzyme activity is present in normal mononuclear phagocytes and macrophage cell lines. we have found this enzyme activity to be present in murine raw264 macrophages, in human u937 macrophages, in normal human blood monocytes, and in guinea pig peritoneal macrophages. all of the raw264 and u ... | 1985 | 2999416 |
| molecular basis of macrophage activation. expression of the low potential cytochrome b and its reduction upon cell stimulation in activated macrophages. | the expression of the novel b-type cytochrome, which is part of the superoxide anion (o2-)-generating system in phagocytes, has been investigated in population of mouse peritoneal macrophages heterogeneous in their capability to produce o2-). reduced minus oxidized difference spectra of intact cells showed the appearance of a b-type cytochrome with major peaks in the alpha region at 558 to 559 nm and in the gamma region at 426 to 428 nm. resident peritoneal macrophages, as well as thioglycollate ... | 1986 | 3003196 |
| deficient ifn alpha production in hairy cell leukemia. | since the application of low doses of ifn-alpha is necessary to maintain remissions in hairy cell leukemia (hcl) it is of interest whether peripheral blood mononuclear cells (mnc) of hcl patients can be induced in vitro to produce ifn-alpha. 9 patients suffering from advanced hcl were included in the study. the diagnoses were confirmed by characteristic findings in peripheral blood and bone marrow biopsies. for ifn treatment we initially used natural ifn-alpha (bioferon) and switched later to re ... | 1986 | 3006840 |
| transfection of corynebacterium lilium protoplasts. | a protoplast transfection system has been developed for a lysine-producing bacterium, corynebacterium lilium, using the dna of phage cl31. phage cl31 is lytic and specific to c. lilium and has a genome of approximately 48 kb. the transfection procedure involves a polyethylene-glycol-mediated introduction of the dna into lysozyme-treated cells and has a maximum efficiency of 3 x 10(4) transfectants per microgram dna. | 1985 | 3007654 |
| protoplast transformation in coryneform bacteria and introduction of an alpha-amylase gene from bacillus amyloliquefaciens into brevibacterium lactofermentum. | the goal of this study was to investigate the likelihood of developing useful transformation systems for coryneform bacteria. two species of coryneform bacteria, brevibacterium lactofermentum and corynebacterium lilium, were transformed with chimeras constructed from pub110 and a cryptic coryneform plasmid (pgx1901). c. lilium protoplasts were also efficiently transfected with phage cs1 dna. high transformation and transfection frequencies were obtained after only 2 min of lysozyme treatment of ... | 1986 | 3008649 |
| experimental and clinical studies on the effects of synthetic muramyldipeptide derivatives on viral and opportunistic infections. | the efficacy of strearoyl-mdp derivatives, l18-mdp and mdp-lys-18 against bacterial and viral infections in mice was examined. both l18-mdp and mdp-lys-l18 stimulated nonspecifically host-resistance against opportunistic infection with c. kutscheri in hydrocrotisone-treated mice against sendai virus infection in mice. | 1986 | 3010013 |
| [role of temperate phage in bacterial dissociation]. | the analysis of literary and own data testifies that the dissociants may appear in bacteria population from spontaneous mutations and transfer of genetic material (conjugation, transformation, transduction). the phage conversion and different dna reorganizations within a cell where prophage plays an active role, probably introduce the largest contribution into the dissociative transitions of variants which occur with high frequency (about 10(-2)-10(-4). the dissociation of various bacteria has b ... | 1986 | 3011128 |
| distribution of intrapleural and intravenous corynebacterium parvum in humans; 99mtc-, and 131i-labeled bacteria. | the distribution of corynebacterium parvum labeled with 131iodine or 99mtechnetium was studied in 17 patients with bronchogenic carcinoma. the labeled bacteria were given intravenously or intrapleurally and monitored by whole-body gamma tracking and samples of blood and urine. even though the rate of physical decay is quite different for 131iodine and 99mtechnetium, the tracking time of labeled bacteria was limited to 24 h after injection for both radioactive isotopes. technetium labeling was pr ... | 1986 | 3011262 |
| corynebacterium parvum-elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident kupffer cells in the rat. | we have recently demonstrated that release of oxygen-derived free radicals by activated hepatic macrophages may be involved in the pathogenesis of a rat model of liver injury induced by corynebacterium parvum and endotoxin. in the present study we have compared the respiratory burst activity of isolated normal rat kupffer cells with that of hepatic macrophages elicited by c. parvum. superoxide production (o2-.) and glucose oxidation via the hexose monophosphate shunt (hmps) were low in normal ku ... | 1986 | 3011580 |
| nadp+ production using thermostable nad+ kinase of corynebacterium flaccumfaciens ahu-1622. | a sonicate of corynebacterium flaccumfaciens ahu-1622 had the highest nad+ kinase activity (1.22 mu/ml culture broth) of the strains of bacteria we investigated. this enzyme was thermostable, with activity maintained at 50 degrees c for 1 h. this treatment inactivated phosphatase activity. resting cells of the bacterium also had nad+ kinase activity when treated at 60 degrees c for 30 min with 0.2% triton x-100. nadp+ production was achieved using 8 mumol nad+, 8 mumol atp, 16 mumol mgcl2, 1.6 m ... | 1986 | 3017521 |
| detection of homology to the beta bacteriophage integration site in a wide variety of corynebacterium spp. | in toxigenic conversion of corynebacterium diphtheriae c7, beta bacteriophage dna integrates into either of two chromosomal attachment sites, attb1 or attb2. these attb sites share a 96-base-pair sequence with the attp sites of beta-related phages. the distribution of attb-related sites in other species of corynebacterium was assessed by hybridization with a dna probe containing both attb sites of the c7 strain and a second dna probe containing the attp site of a beta-related phage. all but one ... | 1986 | 3019994 |
| relationship of success in classical immunotherapy to the relative immunorejective strength of the tumor. | six tumors of varying immunorejective strengths were used to compare the response of their isogenic hosts to standardized regimens of immunoprophylaxis and immunotherapy. the tumors were generated spontaneously or induced chemically [with 9,10-dimethyl-1,2-benzanthracene (cas: 57-97-6)], virally (with murine leukemia virus), or radiogenically (with strontium-90). the hosts were c57bl/6j or balb/cbyj mice. immunoprophylaxis and immunotherapy were performed with isogenic irradiated tumor cells, wi ... | 1986 | 3020300 |
| the role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages. | the in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of listeria monocytogenes egd (listeria) by peritoneal macrophages (pm) was investigated. generation of superoxide anion by pm stimulated with phorbol myristate acetate (pma) was significantly increased by intraperitoneal injection of lactobacillus casei yit 9018 (lc9018) or corynebacterium parvum (cp), but not by injection of peptone. however, superoxide anion generation by lc9018-elicited pm stimulated with li ... | 1986 | 3020680 |
| characterization of a plasmid in isolates of corynebacterium sepedonicum. | lysis of mid-log phase cells of the gram-positive bacterium, corynebacterium sepedonicum, by a combination of lysozyme treatment and incubation with alkaline sodium dodecyl sulfate at 56 degrees c led to the recovery of a single plasmid. the plasmid was purified in cscl density gradients, and its molecular weight estimated to be 31 megadaltons (46 kilobases), as determined from its relative mobility in agarose gels, from its contour dimensions in electron micrographs, and from the size of the fr ... | 1986 | 3021310 |
| characterization and structure of an endoglucanase gene cena of cellulomonas fimi. | two bamhi fragments (0.8 and 5.2 kb) of cellulomonas fimi containing an endoglucanase (eng) gene (cena) were individually cloned into the bamhi site of pbr322; they expressed carboxymethylcellulase activity in escherichia coli. the nucleotide (nt) sequence of the cena gene was determined by sequencing overlapping deletions. the cena gene is 1350 bp long encoding a polypeptide of 449 amino acids (aa) and stop codon. the 0.8-kb bamhi component encodes the first 76 aa, whereas the 5.2-kb bamhi comp ... | 1986 | 3023193 |
| secretion of cellulomonas fimi exoglucanase by escherichia coli. | a leader sequence of 41 amino acids (aa) has been proposed as the signal sequence for the exoglucanase (exg) from cellulomonas fimi. the ability of this 41-aa peptide to function as a leader sequence has been shown here by gene fusion experiments in escherichia coli. a hybrid leader sequence containing c-terminal 37 aa of the leader peptide and n-terminal 6 aa of beta-galactosidase (beta gal) directed export of the exg into the periplasm of e. coli. in contrast, hybrid beta gal-exg proteins in w ... | 1986 | 3023194 |
| cloning and regulation of erwinia herbicola pigment genes. | the genes coding for yellow pigment production in erwinia herbicola eho10 (atcc 39368) were cloned and localized to a 12.4-kilobase (kb) chromosomal fragment. a 2.3-kb avai deletion in the cloned fragment resulted in the production of a pink-yellow pigment, a possible precursor of the yellow pigment. production of yellow pigment in both e. herbicola eho10 and pigmented escherichia coli clones was inhibited by glucose. when the pigment genes were transformed into a cya (adenylate cyclase) e. coli ... | 1986 | 3023282 |
| plasmids in group jk coryneform bacteria isolated in a single hospital. | investigation of 39 jk-type coryneform isolates from patients at a single hospital revealed that 23 possessed plasmids, which formed six groups on restriction endonuclease analysis. four of the groups were associated with production of similar bacteriocin-like substances, and shared a minimum of 6.4 kilobase pairs of dna. these plasmids, found in isolates from different patients, provide strong direct evidence that person-to-person transmission of jk bacteria had occurred within the hospital. | 1986 | 3023480 |
| the effect of kupffer cell stimulation or depression on the development of liver metastases in the rat. | tumour cells from a squamous carcinoma (approximately 2.5 x 10(5)) were injected intraportally into a syngeneic strain of rats to produce liver metastases 14 days later. kupffer cells were stimulated by corynebacterium parvum (7 mg or 1 mg i.v.) and zymosan (10 mg intraportally). kupffer cell activity was depressed by the administration of silica, gadolinium chloride or human red cells. the animals in each group were sacrificed at 14 days, the livers removed and the number of visible surface met ... | 1986 | 3024833 |
| dna element of corynebacterium diphtheriae with properties of an insertion sequence and usefulness for epidemiological studies. | the segment of dna which is inserted within the tox gene of bacteriophage gamma and is responsible for its tox- phenotype was found to be present and repeated approximately 30 times in the chromosome of corynebacterium diphtheriae belfanti 1030. other c. diphtheriae strains contained a variable number of copies (1 to 25) of the same element. sequence analysis showed that this repeated and interspersed dna element was flanked by 9-base-pair direct repeats and that the 5' and 3' ends of the insert ... | 1987 | 3025175 |
| [cloning in escherichia coli of the mutant gene coding the diphtheria toxin]. | bacteriophage beta 45 of corynebacterium diphtheriae was harvested. the extracted dna of the bacteriophage was digested by the restriction endonuclease bamhi and inserted into the bamhi cleavage site of puc19 vector plasmid. plasmid pnvy5 containing a mutant gene crm45 of diphtheriae toxin in a 3.9 bpn fragment was isolated from the hybrid plasmids obtained. cell free extracts of e. coli strain tg1 (pvny5) contain the nontoxic protein crm45 possessing the specific enzymatic activity of diphtheri ... | 1985 | 3025674 |
| hepatocellular carcinoma in an 11-year-old girl with fanconi's anemia. report of a case and review of the literature. | an 11-year-old girl with fanconi's anemia, who died of corynebacterium septicemia, was found at autopsy to have a solitary, previously undiagnosed hepatocellular carcinoma (hcc). although the association between fanconi's anemia and malignancies such as leukemia and squamous cell carcinoma is well documented, its relationship to hcc remains controversial and obscure. anabolic steroid therapy for fanconi's anemia has also been considered a promoter for hepatocellular neoplasms. this report docume ... | 1986 | 3026193 |
| macrophage membrane proteins: possible role in the regulation of priming for enhanced respiratory burst activity. | brief exposure of macrophages to the proteolytic enzymes papain, elastase, or trypsin primed them for enhanced production of superoxide anion (o2-) in response to stimulation by phorbol myristate acetate (pma). priming by trypsin was achieved at 0 degree c, at which temperature trypsin functions as a protease but is not internalized, supporting the concept that protease priming depends on modification of the plasma membrane. analysis of external membrane proteins after radioiodination of intact ... | 1986 | 3026655 |
| [toxigenic phages of corynebacterium diphtheriae]. | | 1986 | 3030029 |
| hepatic reticuloendothelial system activation in autoimmune mice: differences between (nzb x nzw)f1 and mrl-lpr/lpr strains. | 5'-nucleotidase (5'n) activity and ia expression of hepatic nonparenchymal cells (npcs) of the autoimmune (nzb x nzw)f1 and mrl-lpr/lpr and nonautoimmune c3h/fej, dba/2j, and a/j strains were assayed to determine endogenous activation of the hepatic reticuloendothelial system (res). pretreatment of the nonautoimmune strains with corynebacterium parvum resulted in decreases in fc receptor expressor and 5'n and an increase in ia expression of npcs. endogenous hepatic res activation, as measured by ... | 1987 | 3030589 |
| the immunological activities of components isolated from corynebacterium parvum in mice injected with polyoma tumor cells. | the inhibition of polyoma tumor in cba mice after immunization with different fractions of corynebacterium parvum was investigated. treatment with 200 micrograms of polysaccharide from culture filtrate before s.c. inoculation 2 x 10(6) of tumor cells induced antitumor effect in mice. treatment with lower doses (1 microgram or 20 micrograms) after transplantation of tumor cells was not effective. injection of lipopolysaccharide from escherichia coli abolished a positive response on inhibition of ... | 1987 | 3031518 |
| eicosanoid production by peritoneal and splenic macrophages in mice depleted of bone marrow by 89sr. | previous studies showed that the prostaglandin-forming macrophages (m phi) induced in the spleens of cba/j mice by intraperitoneal administration of corynebacterium parvum (cp) could not be demonstrated following the depletion of bone marrow and blood monocytes with 89sr. the present study compares prostaglandin e2 (pge2), leukotriene c4 (ltc4), and ltb4 release by splenic and resident peritoneal m phi in 89sr-treated mice and 88sr controls following in vivo cp and in vitro incubation with zymos ... | 1987 | 3031987 |
| stimulation of the respiratory burst of murine peritoneal inflammatory neutrophils by conjugation with tumor cells. | murine peritoneal neutrophils (pmns), elicited by i.p. injection of formalin-killed corynebacteria parvum, spontaneously lyse teratocarcinoma targets through the secretion of reactive oxygen intermediates. examination of effector-target interactions at the single cell level revealed that pmns conjugated to tumor cells were 3-fold more frequently stained by nitroblue tetrazolium compared to nonconjugating pmns suggesting that tumor targets stimulated a potent tumor-lytic respiratory burst. this n ... | 1987 | 3032419 |
| in vitro activity of ly146032 (daptomycin), a new peptolide. | the in vitro activity of ly146032, a new peptolide antibiotic, was compared with those of vancomycin, teicoplanin, imipenem, amoxicillin and erythromycin. ly146032 inhibited 90% of staphylococcus aureus and staphylococcus epidermidis, including methicillin-resistant isolates at less than or equal to 1 microgram/ml. its activity was comparable to those of vancomycin and teicoplanin. mic90s for the beta-hemolytic streptococci varied from 0.25 microgram/ml for group b streptococci to 4 micrograms/m ... | 1987 | 3032611 |
| in vitro activity of ly146032 (daptomycin) against selected aerobic bacteria. | the in vitro activity of the new lipopeptide antibiotic ly146032 was generally four-fold greater (mic 90 less than or equal to 0.5 microgram/ml) than that of vancomycin against methicillin-susceptible or methicillin-resistant staphylococcus aureus and coagulase-negative species of staphylococcus. enterococci, streptococcus bovis, group b and viridans streptococci, and corynebacterium group j-k isolates were inhibited by less than or equal to 4 micrograms/ml of ly146032, which represented activit ... | 1987 | 3032612 |
| encephalomyocarditis (emc) virus-induced diabetes mellitus prevented by corynebacterium parvum in mice. | corynebacterium parvum prevented the development of encephalomyocarditis virus-induced diabetes in mice, when it was given 3-14 days before the virus infection. this treatment inhibited virus replication in the pancreas of the infected mice at an early stage of the infection. | 1987 | 3032672 |
| structural characteristics of the corynebacterium lilium bacteriophage cl31. | bacteriophage cl31 was isolated on a corynebacterium lilium strain. out of 30 strains tested, only cl31 was able to form plaques on corynebacterium glutamicum atcc 13287, brevibacterium lactofermentum atcc 21086, and arthrobacter sp. strain si55, but at a very low frequency. this phage belongs to group b of bradley's classification (d. e. bradley, bacteriol. rev. 31:230-314; 1967). its head is 53 nm in diameter, and its tail is 396 nm in length. the phage capsid contains three major proteins, of ... | 1987 | 3033280 |
| utilization of glutamate accumulating bacterial cells for production of ribonucleotides. | corynebacterium glutamicum cells are industrially used for glutamate production. however, the waste that contains microbial cells, cellular debris, residual sugars, ammonia and metabolites seriously pollutes the environment. the cells are recovered and utilized for ribonucleotide production so that the pollution caused by the cells is eliminated. nucleic acid is extracted from the cells and is hydrolyzed with nuclease p1 from penicillium citrinum. the hydrolysate is fractionated with dowex-50 an ... | 1985 | 3033725 |
| [synergistic and antagonistic hemolytic reactions of bacterial proteins]. | | 1987 | 3034233 |
| silica gel as transport medium for corynebacterium diphtheriae under tropical conditions (indonesia ) | silica gel was confirmed as a useful transport medium for corynebacterium diphtheriae in the investigation of diphtheria cases in which there is no ready access to laboratory facilities. | 1987 | 3034972 |
| comparative in vitro activity of the new cyclic lipopeptide ly146032 against corynebacterium species. | agar dilution and time-kill techniques were used to assess the in vitro activity of ly146032 and several other antibacterial agents against corynebacterium spp. the activity of ly146032 was similar to that of vancomycin and teicoplanin. synergistic killing by a combination of ly146032 and gentamicin could be demonstrated under certain carefully controlled conditions. | 1987 | 3036499 |
| glucan: mechanisms involved in its "radioprotective" effect. | it has generally been accepted that most biologically derived agents that are radioprotective in the hemopoietic-syndrome dose range (eg, endotoxin, bacillus calmette guerin, corynebacterium parvum, etc) exert their beneficial properties by enhancing hemopoietic recovery and hence, by regenerating the host's ability to resist life-threatening opportunistic infections. however, using glucan as a hemopoietic stimulant/radioprotectant, we have demonstrated that host resistance to opportunistic infe ... | 1987 | 3036990 |
| isolation and characterization of an amphipathic antigen from corynebacterium diphtheriae. | amphipathic antigen was isolated from corynebacterium diphtheriae park-williams number 8 cells by extraction with 47.5% phenol, nuclease treatment and gel filtration on sepharose 6b. the chemical composition of the amphipathic antigen was hexose (73.8%), pentose (4.6%), fatty acids (9.8%) and glycerol (4.5%). the amphipathic antigen contained arabinose and mannose as sugars at a molar ratio of 1:6 and the major fatty acids were palmitic (c16:0) acid and palmitoleic (c16:1) acid (64.2% and 26.2%, ... | 1987 | 3039312 |
| cloning, expression, and nucleotide sequence of a gene encoding a second thioredoxin from corynebacterium nephridii. | a gene encoding thioredoxin in corynebacterium nephridii was cloned in escherichia coli by complementation of a thioredoxin mutant. transformants that appeared to complement were analyzed for the presence of thioredoxin by the coupled assay using methionine sulfoxide reductase. of 18 transformants, four contained high levels of thioredoxin activity. transformants containing plasmids plcn2 and plcn4 were unable to support replication of t7 phage, in spite of their thioredoxin activities, and were ... | 1987 | 3040729 |
| size and homology of the genomes of leprosy-derived corynebacteria, mycobacterium leprae, and other corynebacteria and mycobacteria. | the genomes of mycobacterium leprae and leprosy-derived corynebacteria (ldc), which have a similar base composition of guanine + cytosine 56 mol %, have been compared with those of reference bacteria of the cmn group (genera corynebacterium, mycobacterium, nocardia). genome sizes of three ldc strains were (1.2-2.5) x 10(6) base pairs. dna from four of seven ldc strains examined had homology levels greater than 60%. two other strains had a homology of 40% when compared with the cmn strains and on ... | 1988 | 3050108 |
| chronic vitritis with macrophagic inclusions. a sequela of treated endophthalmitis due to a coryneform bacterium. | a 75-year-old woman was treated successfully for endophthalmitis due to a coryneform bacterium contracted from a contaminated corneal graft. we were able to study the involved eye histologically when the patient died unexpectedly 5 1/2 weeks after treatment. the vitreous contained a moderate number of macrophages filled with pas-positive particles. ultrastructurally, the pas-positive particles corresponded to degenerating bacterial cell walls. the striking resemblance of the macrophages in this ... | 1988 | 3050675 |
| differential effect of inflammatory stimuli on murine plasma c4 and factor b concentrations. | the in vivo effects of a variety of inflammatory stimuli on complement c4 and factor b plasma levels have been examined. mrl/++ (h-2k) mice were given intraperitoneal injections of lipopolysaccharide, turpentine, corynebacterium parvum pyridine extract residue or high doses of indomethacin. all of these treatments induced an increase in plasma factor b concentrations, which in the case of c. parvum was dose dependent and persisted for at least 7 days. lipopolysaccharide, turpentine and indometha ... | 1988 | 3052973 |
| differences between beige and bg/+ mice in the disruption of plasma proteinase regulation in the tumor-bearing state or following corynebacterium parvum treatment. evidence for the involvement of polymorphonuclear leukocyte proteinases. | mice bearing the b16 melanoma or treated with corynebacterium parvum develop elevated levels of plasma neutral proteinase activity. similar experiments carried out with c57bl/6-bg/bg (beige) mice, which are genetically deficient in polymorphonuclear neutrophil (pmn) proteinases, revealed that such mice develop significantly diminished elevation in plasma proteinase activity compared to c57bl/6-bg/+ mice. lysates of c. parvum elicited pmn from beige mice contained approximately 80% less neutral p ... | 1988 | 3053356 |
| corynebacterium group d2 and urolithiasis in a boy with megacalycosis. | this is report on a boy with megacalycosis in whom infectious urolithiasis after eradication of proteus mirabilis was maintained by corynebacterium group d2. | 1988 | 3053458 |
| the clinical use of macrolides. | macrolides are active against streptococcus pneumoniae, legionella spp. and mycoplasma pneumoniae, the main causes of community-acquired pneumonia they may therefore be used for the empirical treatment of community-acquired pneumonia, although emergent resistance in str. pneumoniae limits their use in some parts of the world. in patients with bronchitis the use of macrolides reduces the severity and duration of symptoms. macrolides have also been used successfully in the treatment of otitis medi ... | 1988 | 3053568 |
| identification of actinomyces (corynebacterium) pyogenes with the api 20 strep system. | a total of 62 strains of actinomyces pyogenes (previously corynebacterium pyogenes) were examined by the api 20 strep system (api system, la balme les grottes, montalieu-vercieu, france). the system was shown to be reliable and rapid when the tests were compared with standard identification methods. no confusion occurred with streptococcal profiles in the current api 20 strep data base. | 1988 | 3053779 |
| [urinary corynebacterium group d2 infections. a hospital epidemic and antibiotic sensitivity]. | an outbreak of corynebacterium group d2 urinary tract infections was recently observed at nice chr. these infections were characterized by alkaline urine. the five first cases were reported in the same department and the ten other cases were latter observed in different departments. age average was 79 and all patients had either an intra-vesical catheter of a urinary collector. among samples of material tested, only one gave a positive culture. the 15 isolates showed a similar identification and ... | 1988 | 3054760 |
| e. coli infections of the lower urinary tract and their treatment by immunomodulation or combined immunomodulation and antigen therapy. | a model of infection by e. coli 022 of the lower urinary tract in the rat is described. the infection is characterized by the presence in the urine of a large number of e. coli (10(5)-10(7) bacteria per ml). there is pus formation in the urine. a few infected rats also exhibited prostate hypertrophy and the presence of acb could be detected in some of the latter group. treatment of the infected rats by the c. granulosum-derived immunomodulator p40, injected intravenously either as a single dose ... | 1988 | 3056533 |
| summer mastitis: transmission by blood feeding flies. | | 1988 | 3057716 |
| summer mastitis. | | 1988 | 3059664 |
| thin bridgelike connections between cells in mycobacterium bovis bcg and in corynebacterium glutamicum. | | 1988 | 3060045 |