| different species of corynebacteria in human investigations in cairo. | in investigations undertaken in cairo of ocular smears the following corynebacteria were isolated: corynebacterium a4, corynebacterium a5, corynebacterium bovis, corynebacterium aquaticum, corynebacterium diphtheriae, corynebacterium equi, corynebacterium f2, corynebacterium kutscheri, corynebacterium minutissimi, corynebacterium renale, corynebacterium xerosis, corynebacterium group i, corynebacterium spec. (at present not classified). in this study the hitherto isolated species and possible hu ... | 1989 | 2689286 |
| suppression of resistance to salmonella typhimurium in young chickens inoculated with corynebacterium parvum. | the effect of corynebacterium parvum on resistance to salmonella typhimurium infection was evaluated in young chickens. one-day-old chickens were inoculated subcutaneously (sc) or intraperitoneally (ip) with 1.4 mg killed c. parvum and challenged by ip injection with 5.0 x 10(7) s. typhimurium 4 days later. spleen and bursa of fabricius weights were not altered in the c. parvum-inoculated chickens. a transient increase in thymus weight occurred 3 days after inoculation with c. parvum. phytohemag ... | 1989 | 2695051 |
| [the mitogenic activity of the glycopolymers from clavibacter (corynebacterium) michiganense and pseudomonas solanacearum]. | a comparative study of the mitogenic activity of glycopolymers has shown that the activity of polysaccharides isolated from clavibacter michiganense is higher than that of lipopolysaccharide of escherichia coli, pseudomonas solanacearum and mefenaminic acid (the synthetic mitogen). lipid a and the core oligosaccharide fraction are established to be responsible for the mitogenic activity of the p. solanacearum lipopolysaccharide. o-specific chains and fractions of kdo-phosphates do not manifest t ... | 1989 | 2695796 |
| adjuvant immunotherapy in node-negative patients: results of a scandinavian study. | | 1989 | 2696032 |
| depression of nonadaptive immunity after surgical stress: influence on metastatic spread. | the question of increased tumor cell dissemination after surgical stress was addressed in the model system of the spontaneously metastasizing rat adenocarcinoma bsp73asml, wherein amputation of the hind leg 7 days after intrafootpad implantation of tumor cells cured the animals, while surgical stress by laparotomy 2 days prior to amputation resulted in lung metastases in 80% of rats. a detailed in vitro analysis of natural killer (nk) and macrophage (mo) activity in different lymphatic compartme ... | 1989 | 2703300 |
| transport of branched-chain amino acids in corynebacterium glutamicum. | the transport of branched-chain amino acids was characterized in intact cells of corynebacterium glutamicum atcc 13032. uptake and accumulation of these amino acids occur via a common specific carrier with slightly different affinities for each substrate (km[ile] = 5.4 microm, km[leu] = 9.0 microm, km[val] = 9.5 microm). the maximal uptake rates for all three substrates were very similar (0.94 - 1.30 nmol/mg dw.min). the optimum of amino acid uptake was at ph 8.5 and the activation energy was de ... | 1989 | 2705860 |
| renal medullary amyloidosis in dorcas gazelles. | between january 1976 and september 1987 renal medullary amyloidosis (rma) was diagnosed in 17 dorcas gazelles; the necropsy prevalence rate was 17/32 (53%). the most severe amyloid deposits were in the renal medulla; glomeruli were spared. renal cortical lesions of interstitial fibrosis and tubular atrophy and dilatation significantly correlated with rma (p less than 0.01) and were considered to be secondary changes. there were varying degrees of lymphoplasmacytic inflammation and tubular cast f ... | 1989 | 2711570 |
| [practical use of antiseptics in dermatology]. | | 1989 | 2712488 |
| infection following challenge of the lactating and dry udder of dairy cows with actinomyces pyogenes and peptostreptococcus indolicus. | challenge of 12 mammary glands of cows in mid-lactation with 10(7) colony forming units (cfu) of peptostreptococcus indolicus on two occasions led to clinical mastitis in only four quarters. the bacteria were rarely recovered and disappeared from the secretion within 14 days. in challenges 7 days prior to drying off eight of 12 quarters became infected and at drying off all quarters challenged became infected. the infections established at drying off persisted well into the dry period. p. indoli ... | 1989 | 2713635 |
| immunohistochemical localization of immunoglobulins in bovine granulomatous lesions. | the immunohistochemical distribution of igg, iga and igm in granulomatous lesions caused by actinomyces bovis, actinobacillus lignieresi, actinomyces (corynebacterium) pyogenes, pseudomonas aeruginosa, staphylococcus aureus and mycobacterium bovis was studied. numerous igg-containing cells (plasma cells) were distributed in the peripheral connective tissue layers, but not in the epithelioid cell layer. a few scattered iga- and igm-containing cells were found in all the lesions examined. mycobact ... | 1989 | 2715395 |
| corynebacterium group jk infections in children. | | 1989 | 2717276 |
| the effect of gomisin a on immunologic liver injury in mice. | the hepatoprotective effect of gomisin a (tjn-101), which is a lignan compound isolated from schizandra fruits, was studied on three immunologic liver injury models in mice. the first liver injury model was produced by the injection of anti-basic liver protein (blp) antibody into dba/2 mice which had been previously immunized with rabbit igg (rgg). other models were effected by injection of anti-liver specific protein (lsp) antibody into dba/2 mice or by the injection of bacterial lipopolysaccha ... | 1989 | 2717684 |
| pathology of culture-proven jk corynebacterium pneumonia. an autopsy case report. | the first description of the pathologic characteristics of jk corynebacterium pneumonia is presented. occurring in a profoundly neutropenic patient, the pneumonia was characterized by massive fluid exudation in the alveoli with acute hemorrhage, significant proliferation of the bacteria beginning along the alveolar walls, and eventual alveolar wall necrosis. other cases of jk corynebacterium pneumonia are reviewed. this report emphasizes that jk corynebacterium pneumonia has a high mortality and ... | 1989 | 2718963 |
| duration of experimentally induced corynebacterium bovis colonization of bovine mammary glands during the lactating, nonlactating, and peripartum periods. | bovine mammary glands were inoculated intracisternally with a streptomycin-resistant (sr) strain of corynebacterium bovis to determine the number of colony-forming units (cfu) required to induce colonization and to maintain persistence of c bovis colonization throughout lactation and involution. streptomycin resistance was used as a strain marker. uninfected quarters in cows during midlactation were challenge exposed with successively higher numbers of sr c bovis until all quarters became coloni ... | 1989 | 2719392 |
| [isolation of corynebacterium jk from the blood of neutropenic patients with septic diseases]. | the authors report on the isolation of corynebacterium jk from the blood of two neutropenic patients with hematological malignancy. in hungary this paper is the first to discuss the microbiology of the organism and clinical manifestations of the group jk coryneform infection. the clinical significance of this organism in the nosocomial infections of compromised patients and the association of the infection with the use of plastic devices has been emphasized. the sensitivity of the multiresistant ... | 1989 | 2734015 |
| lymphocytes generated by in vivo priming and in vitro sensitization demonstrate therapeutic efficacy against a murine tumor that lacks apparent immunogenicity. | the adoptive transfer of sensitized lymphocytes is an effective means to mediate the regression of established tumors. however, successful therapy can only be demonstrated in animal models where tumors are intrinsically immunogenic, capable of eliciting systemic immunity. to explore the potential of this therapeutic approach to tumors of less immunogenicity, we have selected and used a murine tumor, mca 102, for the current study because all attempts to immunize syngeneic mice failed. we report ... | 1989 | 2738408 |
| observations on sudanese camel nasal myiasis caused by the larvae of cephalopina titillator. | forty-four camels slaughtered at nyala abattoir, western sudan, were examined for infection with the larvae of cephalopina titillator. the infection rate was found to be 100 p. 100. the parasitic burden ranged between 8-243 per animal. they were recovered throughout the year. the first stage larvae were noticed from december to may, indicating the breeding season of the fly. the larvae were found to cause visible pathological lesions on the nasopharynx. these were also demonstrated histopatholog ... | 1989 | 2740563 |
| leukocytic infiltration of bovine mammary parenchymal tissue in response to corynebacterium bovis colonization. | morphological changes and local leukocyte response to prolonged corynebacterium bovis colonization were studied in lactating bovine mammary glands. morphometric analysis of parenchymal tissue demonstrated no adverse effects of colonization on the synthetic and secretory activity of mammary epithelium. numbers of macrophages, lymphocytes, and plasma cells were higher in tissue from c. bovis-colonized quarters. however, there were no differences in numbers of neutrophils between colonized and unin ... | 1989 | 2745807 |
| chemiluminescence in a macrophage cell line modulated by biological response modifiers. | we have studied a murine macrophage cell line, j774, and found these cells capable of a zymosan-triggered chemiluminescent oxidative burst. such activity was enhanced by preincubation with corynebacterium parvum (cp), bacillus calmette-guerin, and lipopolysaccharide (lps). under similar conditions, cp and lps were shown to enhance j774-mediated tumor cell lysis. we have also demonstrated that murine interferon alpha + beta rendered j774 cells more sensitive to the actions of cp and lps. these re ... | 1989 | 2746137 |
| effects of products from inflammatory pulmonary neutrophils on alveolar macrophage chemotaxis, spreading, and thymidine incorporation. | since macrophages and neutrophils are found together in the alveolar region of the lung during alveolar inflammation, we assessed whether neutrophil products could influence three key functions of alveolar macrophages: chemotaxis, spreading, and thymidine incorporation. neutrophils were obtained from the lungs of rats treated by intratracheal instillation of heat-killed corynebacterium parvum and cultured overnight, alone or in the presence of zymosan, pma, an inert particulate (titanium dioxide ... | 1989 | 2759686 |
| corynebacterium equi peritonitis in a patient receiving peritoneal dialysis. | our patient represents the first reported case of peritonitis due to c equi. he had no known exposure to farm or domestic animals, and no evidence of underlying systemic immunodeficiency. after relapse, the patient was successfully treated with vancomycin, and catheter removal was not necessary. we suggest that c equi be added to the growing list of organisms not typically thought to be human pathogens that can cause peritonitis in patients receiving capd and recommend intraperitoneal vancomycin ... | 1989 | 2762888 |
| corynebacterium kutscheri septic arthritis. | | 1989 | 2765007 |
| [the etiology of renal calculi]. | | 1989 | 2765999 |
| the use of a microagglutination assay for the detection of antibodies to corynebacterium pseudotuberculosis in naturally infected sheep and goat flocks. | two goat flocks comprising 326 animals and four sheep flocks comprising 343 animals, all with a previously recognized problem of abscesses due to corynebacterium pseudotuberculosis, were examined for the presence of abscesses and antibody titers to c. pseudotuberculosis as detected by direct microagglutination assay. in sheep there was a strong positive relationship between age and titer (p less than 0.0001). however, the relationship in goats between age and titer could not be determined due to ... | 1989 | 2766152 |
| trichomycosis axillaris: a different view. | | 1989 | 2768591 |
| diphtheroids as ocular pathogens. | unlike corynebacterium diphtheriae and propionibacterium acnes, the pleomorphic gram-positive rods known as diphtheroids are generally regarded as nonpathogenic contaminants of the human external eye. we reviewed five years of microbiology records at wills eye hospital and studied a series of eight cases of apparently infectious keratitis associated with heavy growth of diphtheroids on cultures of ulcer scrapings. all of these cases included indolent ulcers that occurred almost exclusively in el ... | 1989 | 2774033 |
| antimicrobial activity of julifloricine isolated from prosopis juliflora. | antimicrobial activity of julifloricine, an alkaloid isolated from prosopis juliflora, was studied in vitro against 40 microorganisms which included 31 bacteria, two candida species, five dermatophytic fungi and two viruses. significant inhibitory effect was noted against gram positive bacteria. the minimal inhibitory concentration (mic) for staphylococcus aureus, s. epidermidis, s. citreus, streptococcus pyogenes and sarcina lutea was 1 microgram/ml and against s. faecalis, s. pneumoniae, s. la ... | 1989 | 2775330 |
| [effect of corynebacterium parvum preparation on selected immunologic indicators and clinical results in patients with chronic post-traumatic osteomyelitis]. | nineteen patients with chronic post-traumatic staphylococcal osteitis++ of a mean 5-years-clinical course were given intramuscularly 3.5 mg of coparvax for two weeks. an increase of igg concentration in the serum, starting from the 8th week of observation, and a marked increase of the ability of absorbtion and destruction of staphylococci by the neutrophils of the peripheral blood have been found. it has been accompanied by subsidence of clinical symptoms of ostitis in 13 patients and a marked d ... | 1989 | 2776505 |
| isolation and identification of coagulase-negative staphylococcus species from bovine body sites and streak canals of nulliparous heifers. | heifers (n = 103) ranging in age from 1d to 2 yr were sampled to determine the coagulase-negative staphylococcal flora of haircoat, nares, vagina, teat skin, and streak canal. a total of 2706 staphylococal strains were identified from 3612 bacterial isolates. other genera or groups identified included bacillus, micrococcus, corynebacterium, and coliforms. staphylococci were identified utilizing a simplified biochemical scheme. staphylococcus xylosus, s. chromogenes, and s. warneri were the predo ... | 1989 | 2778172 |
| the phosphoenolpyruvate carboxylase gene of corynebacterium glutamicum: molecular cloning, nucleotide sequence, and expression. | the ppc gene of corynebacterium glutamicum encoding phosphoenolpyruvate (pep) carboxylase was isolated by complementation of a ppc mutant of escherichia coli using a cosmid gene bank of chromosomal c. glutamicum dna. by subsequent subcloning into the plasmid puc8 and deletion analysis, the ppc gene could be located on a 3.3 kb sali fragment. this fragment was able to complement the e. coli ppc mutant and conferred pep carboxylase activity to the mutant. the complete nucleotide sequence of the pp ... | 1989 | 2779518 |
| a seroepidemiological investigation of corynebacterium pseudotuberculosis infection in sheep flocks in southern norway. | | 1989 | 2782227 |
| purification of the phospholipase d of corynebacterium pseudotuberculosis by recycling isoelectric focusing. | recycling isoelectric focusing was investigated as a method for purification of phospholipase d (pld) from cultures of corynebacterium pseudotuberculosis. supernatant fluids from cultures of equine isolate 155 in brain-heart infusion broth were dialyzed against distilled water, concentrated by lyophilization, and fractionated by preparative isoelectric focusing in free solution in a ph 3 to 13 gradient with 6m urea. protein concentration, ph, and pld activity of the 10 resulting fractions were d ... | 1989 | 2782713 |
| distinct immunologic specificity of tumor regression mediated by effector cells isolated from immunized and tumor-bearing mice. | sensitized t lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. employing the mca 105 and mca 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with corynebacterium parvum. these immune splenocytes could be further sensitized and expanded in culture by the in vitro sensitization (ivs) method utilizing tumor stimulator cells and il-2. adoptive immunotherapy of pulmonary metastases med ... | 1989 | 2785860 |
| hematologic interactions of endotoxin, tumor necrosis factor alpha (tnf alpha), interleukin 1, and adrenal hormones and the hematologic effects of tnf alpha in corynebacterium parvum-primed rats. | endotoxin reduces the release among other cytokines of tumor necrosis factor (tnf) and interleukin 1 (il-1) and causes peripheral lymphopenia and a dose-response-dependent initial neutropenia followed by a monophasic neutrophilia. tnf alone induces lymphopenia and an initial neutropenia followed by a biphasic neutrophilia. il-1 alone induces lymphopenia and a monophasic neutrophilia. tnf-plus-il-1 caused a greater lymphopenia than either monokine alone, suggesting that both monokines contribute ... | 1989 | 2786048 |
| origin and fate of ige-bearing lymphocytes. ii. modulation of ige isotype expression on peyer's patch cells by feeding with certain bacteria and bacterial cell wall components or by thymectomy. | mechanisms regulating the appearance of sige+ b lymphocytes appear to be lacking in adult germfree (gf) rats in that their peyer's patches (pp) contain high numbers of cells with sige (approximately 15% of total cells), one-half of which simultaneously express siga, whereas sige+ cells are absent from pp of conventional rats (less than 1%). gf rat pp also contain elevated numbers of siga+ cells and decreased numbers of sigm+ cells, with elevated numbers of sthy-1+ rt 7.1+ ig- t cells, and reduce ... | 1989 | 2789249 |
| [comparison of the effectiveness and adverse effects of a corynebacterium parvum vaccine made in czechoslovakia with coparvax, a british preparation made by wellcome, in the treatment of malignant pleural effusions]. | malignant pleural effusion complicates various malignant diseases, most frequently lung and breast cancer. a group of 20 patients with this complication were treated with the czechoslovak vaccine corynebacterium parvum and the english preparation coparvax, and their effects and side-effects were compared. within 4 weeks following the application, 7 patients died. in 9 surviving patients, the exudate ceased to be replenished and in 4 persons, after intrapleural application of the preparation, it ... | 1989 | 2790915 |
| corynebacterium jeikeium (group jk diphtheroids) endocarditis. a report of five cases. | corynebacterium jeikeium is the name recently given to a group of coryneform rods, formerly known as the jk group, and associated with a wide range of serious infections. we describe five patients with c. jeikeium endocarditis observed in two belgian hospitals over a period of 5 years. in three cases, the infection occurred on prosthetic heart valves between 1.5 and 5 months after surgery. the two other patients, with known mitral insufficiency, presented with endocarditis on native valves. in f ... | 1989 | 2791490 |
| [the ratios and kinds of clinical bacteria isolated in taiwan's large-size hospitals]. | the prevalence of clinical bacteria, as isolated from linko chang-gung memorial hospital (2,300 beds) in the period january 1985 to december 1986 and from taipei veterans general hospital (2,300 beds) during the period january 1986 to december 1986, was analyzed with the following findings: (i) the isolation ratio of anaerobic and aerobic or facultative bactria during the period of investigation were 7.8% (5,513/70,799) and 92.2% (65,286/70,799), respectively. (ii) of the total aerobic or facult ... | 1989 | 2791722 |
| toxicity of il-2 and corynebacterium parvum following direct intracranial injection. | the toxicity of il-2 and/or c. parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of il-2, different solvents for the il-2, and different doses and routes of administration of c. parvum. two injections was found significantly to increase mortality (19%) over a single injection (4%). mortality from two injections of 30,000 u (23%) or 60,000 u (20%) was higher than from two injections of 15,000 u (12 ... | 1989 | 2795120 |
| [action of microbe-antagonists on bacilli and corynebacteria of the skin of the breast in nursing women]. | five microbes-antagonists are studied for their inhibitory action on 769 strains of bacilli (241) and corynebacteria (528) isolated from the mammary gland skin of 120 nursing women on the 2nd-5th day after labour. escherichia coli m-17 and mycococcus krassilinikovi are established to possess the highest antagonistic properties against the spore-bearing aerobic and coryneform bacteria. bifidobacterium bifidum has exerted a moderate antagonistic action on the culture under study, bacillus subtilis ... | 1989 | 2796786 |
| [comparative in vitro bacteriostatic and bactericidal effect of 5 macrolides: roxithromycin, erythromycin, oleandomycin, josamycin and spiramycin against 284 hospital bacterial strains]. | the bacteriostatic and bactericidal activities of five macrolides (roxithromycin, erythromycin, troleandomycin, josamycin and spiramycin) were tested against 284 bacterial strains belonging to various species of gram positive (staphylococci, streptococci, pneumococci, listeria sp, corynebacterium sp, bacillus sp) and gram negative bacteria (neisseria sp, h. influenzae, p. multocida). the activity of these compounds on the whole strains showed near results: 71.8% of susceptible strains to erythro ... | 1989 | 2797879 |
| comparison of the exotoxins of four strains of corynebacterium pseudotuberculosis. | the activity of exotoxins produced by four strains of corynebacterium pseudotuberculosis were compared by their ability to kill white mice, their haemolytic activity, staphylococcal haemolysin-inhibiting effect and activity in an enzyme-linked immunosorbent assay (elisa). exotoxins with a haemolytic titre of 1 in 256 or more killed all mice and had the most inhibitory effect (1 in 64 or more) on staphylococcal haemolysin. the haemolytic test and staphylococcal haemolysin inhibitory test of exoto ... | 1989 | 2799075 |
| [thin-layer chromatography of mycolic acids methanolysates of whole-cell in mycobacterium and related bacteria]. | mycolic acid methanolysates of whole-cell in mycobacterium and related bacteria were analysed by thin-layer chromatography. the experimental results show that five of twenty-two species, m. tuberculosis, m. bovis, m. kansasii, m. marinum and m. gastri have similar pattern of mycolates, composed of alpha-mycolates, methoxymycolates, ketomycolates and two unknown components. m. gilvum, m. phleri, m. avium, m. intracellulare, m. xenopi and m. nonchromogenicum contain alpha-mycolates, ketomycolates ... | 1989 | 2800535 |
| opsonophagocytosis of bacteria studied by chemiluminescence in microtitre plates. | a protocol for polymorphonuclear leukocyte chemiluminescence (pmn cl) assays of opsonophagocytosis was developed for a microtitre-plate luminometer. the complete procedure was performed in a single microtitre plate and was simpler and more efficient than previous protocols. the kinetics of the pmn cl response were best when microtitre plates were incubated on a shaking incubator between readings. the new protocol was used in a study of the pathogenicity of corynebacterium jeikeium, an organism f ... | 1989 | 2801217 |
| evidence of t-cell recognition in mice of a purified lipophosphoglycan from leishmania major. | we have previously reported that a leishmania major lipophosphoglycan (lpg), given with killed corynebacterium parvum as an adjuvant, can vaccinate mice against cutaneous leishmaniasis. in order to analyze whether t cells are able to recognize this important parasite antigen, we have studied both humoral and cellular immune responses to l. major lpg that had been isolated from promastigotes by sequential solvent extraction and hydrophobic chromatography. the data show that immunization of mice w ... | 1989 | 2807527 |
| immunological mechanisms of antitumor activity of some kinds of crude drugs on tumor necrosis factor production. | previously, we described the antitumor activity of four crude drugs, a. capillaris, s. doederleinii, a. macrocephala and s. subprostrata. tumor necrosis factor (tnf) can be produced in animals by injecting bacillus calmette-guerin (bcg) or corynebacterium parvum (cp) as priming agents and endotoxin (lps) as an eliciting agent. however, because of their severe toxic action, it is inappropriate to use these agents to induce intrinsic tnf in cancer patients. in the present paper, we began with the ... | 1989 | 2807633 |
| activity of meropenem, against gram-positive bacteria. | a new carbapenem antibiotic, meropenem, was shown to be active against a large number of gram-positive bacteria. the drug inhibited penicillinase-positive and -negative, methicillin-susceptible staphylococci equally well. among the comparative antimicrobials examined, only n-formimidoyl-thienamycin (imipenem) was two to four times more active than meropenem. compared with vancomycin or methicillin, meropenem was 10-20 times more active. strains of 11 species of streptococci were highly susceptib ... | 1989 | 2808202 |
| [anatomical study of the fibrosing action of corynebacterium parvum in malignant pleural effusion]. | intrapleural injection of corynebacterium parvum (cbp) has recently been used for the treatment of recurrent neoplastic pleural effusions and its mechanism of action has been suggested to be either a local fibrosis-stimulating effect or immunostimulation. the case is reported of a patient with pleuritis secondary to metastases of mammary carcinoma, treated with cbp plus methylprednisolone, who died five days after the treatment because of an acute myocardial infarction. the pathologic examinatio ... | 1989 | 2812462 |
| detection of bacterial cell wall hydrolases after denaturing polyacrylamide gel electrophoresis. | cell walls from various gram-positive bacteria were incorporated at a concentration of 0.2% (w/v) into polyacrylamide gels as a substrate for detection of cell wall hydrolases. bacterial extracts from crude cell wall preparations were denatured with sodium dodecyl sulfate and 2-mercaptoethanol and subjected to denaturing polyacrylamide gel electrophoresis in gels containing bacterial cell walls. after renaturation in the presence of purified and buffered 1% (v/v) triton x-100, cell wall hydrolas ... | 1989 | 2819603 |
| in-vitro activity of ly146032 against staphylococcus aureus, listeria monocytogenes, corynebacterium jk, and bacillus spp., in comparison with various antibiotics. | the in-vitro activity of ly146032 was studied against staphylococcus aureus, listeria monocytogenes, corynebacterium jk, and bacillus spp. in comparison with several agents with action against gram-positive bacteria. ly146032 showed an mic90 of 0.4 mg/l for s. aureus, regardless of the resistance to penicillin or oxacillin. ly146032 was equivalent in activity to ciprofloxacin and vancomycin against s. aureus and moderately active against other species tested (mic90, 0.8-3.2 mg/l). | 1987 | 2822648 |
| ly146032: activity and resistance development in vitro. | ly146032, a new lipopeptide antibiotic, was compared with vancomycin, teicoplanin, cefamandole and ciprofloxacin, against 107 clinical isolates comprising methicillin-susceptible and methicillin-resistant staphylococcus spp., streptococcus faecalis and corynebacterium spp. all staphylococci were susceptible to all agents, except that some of the methicillin-resistant strains were resistant to cefamandole. only ly146032 and ciprofloxacin were bactericidal to str. faecalis. development of resistan ... | 1987 | 2824427 |
| molecular epidemiology of the 1984-1986 outbreak of diphtheria in sweden. | despite mass vaccination against diphtheria, many people have antibody titers below the protective level of 0.01 iu per milliliter. a recent outbreak of diphtheria in sweden caused 17 clinical cases of diphtheria in the city of göteborg; three of the patients died. a satellite outbreak occurred in stockholm after a few months' delay. using a new genetic probe, we analyzed 36 strains of corynebacterium diphtheriae isolated in sweden and denmark during the period 1976 to 1986. although the 36 stra ... | 1988 | 2827023 |
| dna methylation in leprosy-associated bacteria: mycobacterium leprae and corynebacterium tuberculostearicum. | the dnas of two kinds of microorganisms from human leprosy lesion, mycobacterium leprae and corynebacterium tuberculostearicum (also known as "leprosy-derived corynebacterium" or ldc), have been analysed and compared with the genomes of reference bacteria of the cmn group (genera corynebacterium, mycobacterium and nocardia). the guanine-plus-cytosine content (% gc) of dna was determined by a double-labelling procedure, which is unaffected by the presence of modified and unusual bases (that alter ... | 1988 | 2828900 |
| biochemical and genetic characterization of corynebacterium pseudotuberculosis. | isolates (n = 94) of corynebacterium pseudotuberculosis were obtained from sheep, goats, horses, and cattle from various parts of the world. the isolates were characterized biochemically and by restriction endonuclease analysis of dna. we found near homogeneity in the ability of isolates to ferment carbohydrates and to produce urease. all isolates produced phospholipase d and catalase. the ability of isolates from horses to reduce nitrate, the inability of isolates from sheep and goats to do so, ... | 1988 | 2831763 |
| electron microprobe x-ray analysis of polyphosphate granules in plesiomonas shigelloides. | electron-dense inclusion bodies were found in most plesiomonas shigelloides cells, regardless of the incubation time. at the 4-hr incubation period, the size of inclusion bodies was distributed in the range of 50 to 150 nm in diameter, and at the logarithmic phase of growth it increased up to a size visible by light microscope. by an electron microprobe x-ray analysis, phosphorus, potassium, and magnesium were detected in the inclusion bodies which confirms the assumption of pastian and bromel ( ... | 1987 | 2832712 |
| bone marrow derived macrophages have polyamine and ectoenzyme phenotypes distinct from resident macrophages. | several prototype macrophage (mo) populations were compared for differences in ectoenzyme phenotype and polyamine content. resident peritoneal mo and corynebacterium parvum (cp)-activated peritoneal mo expressed unique ectoenzyme phenotypes, while bone marrow derived mo (bmdmo), obtained from stem cells after 7 days in culture with colony stimulating factor, and thioglycollate (tg)-elicited peritoneal mo exhibited a similar ectoenzyme phenotype. all of the mo populations, however, differed in po ... | 1988 | 2835568 |
| organization and regulation of the corynebacterium glutamicum hom-thrb and thrc loci. | the genes encoding the three terminal enzymes in the threonine biosynthetic pathway, homoserine dehydrogenase (hom), homoserine kinase (thrb) and threonine synthase (thrc) have been isolated from corynebacterium glutamicum. the c. glutamicum hom and thrb genes were subcloned on a 3.6 kb sali-generated chromosomal fragment. the c. glutamicum thrc gene was shown not to be linked to the hom-thrb locus. l-methionine represses the cloned homoserine dehydrogenase and homoserine kinase similar to that ... | 1988 | 2835590 |
| nucleotide sequence and fine structural analysis of the corynebacterium glutamicum hom-thrb operon. | the complete nucleotide sequence of the corynebacterium glutamicum hom-thrb operon has been determined and the structural genes and promoter region mapped. a polypeptide of mr 46,136 is encoded by hom and a polypeptide of mr 32,618 is encoded by thrb. both predicted protein sequences show amino acid sequence homology to their counterparts in escherichia coli and bacillus subtilis. the promoter region has been mapped by s1-nuclease and deletion analysis. located between -88, rna start site and -2 ... | 1988 | 2835591 |
| nucleotide sequence of the lysa gene of corynebacterium glutamicum and possible mechanisms for modulation of its expression. | sequence analysis localized the lysa gene of corynebacterium glutamicum strain as019 within a 1.35 kb open reading frame, potentially encoding a 445 amino acid product. immediately downstream from this gene we found a potential rho-independent transcription terminator, while the 5' flanking region (300 bp) harbors unusual topological and structural features, located in the vicinity of a potential ribosome binding site. within this upstream region, enzymatic and genetic analyses indicated the occ ... | 1988 | 2836698 |
| differential in vitro modulation of suppressor and antitumor functions of mouse macrophages by lymphokines and/or endotoxin. | peritoneal macrophages of normal mice exhibited natural suppressor activity, as indicated by their ability to inhibit the proliferation of spleen cells in response to stimulation with phytohemagglutinin (pha) or concanavalin a (con a). their suppressor function could be modulated in vitro with a variety of treatment regimens. high-dose lipopolysaccharide (lps) (lpsh; 10 micrograms/ml) or lymphokines (supernatant from con a-stimulated spleen cells) plus low-dose lps (lpsl; 10 ng/ml) caused a redu ... | 1988 | 2839302 |
| epidemiology of diphtheria: polypeptide and restriction enzyme analysis in comparison with conventional phage typing. | several methods for epidemiological typing of corynebacterium diphtheriae were compared with the well accepted phage typing analysis. for this purpose, isolates from outbreaks of diphtheria in specific areas of the frg and sweden were analyzed by phage typing, their bacterial polypeptide profiles were examined and their phage-dna restriction enzyme patterns were compared. all techniques were able to identify whether certain outbreaks were epidemiologically linked or not. phage typing and phage-d ... | 1988 | 2839340 |
| effect of macrophage activation on resistance of mouse peritoneal macrophages to infection with herpes simplex virus types 1 and 2. | to define the effect of heterogeneity of murine peritoneal macrophages (m phi) on intrinsic resistance to herpes simplex virus (hsv) infection, several m phi populations were characterized for their response to infection with hsv type 1 (hsv-1) and hsv-2. steady-state resident m phi (res m phi) were compared in parallel with m phi activated with corynebacterium parvum (now designated propionibacterium acnes) (cp m phi) and thioglycollate-elicited inflammatory m phi (tg m phi). res m phi were com ... | 1988 | 2841412 |
| in-vitro activity of ly146032 daptomycin and other agents against jk diphtheroids. | | 1988 | 2842282 |
| oxidant production by control and inflammatory bronchoalveolar leukocyte populations treated with mineral dusts in vitro. | using a rat model we set out to determine whether exposure of bronchoalveolar-derived leukocytes to pathogenic mineral dusts in vitro caused them to undergo an oxidative burst and release potentially harmful oxidants. three different populations, obtained by bronchoalveolar lavage, were chosen: control cells, cells obtained following instillation of heat-killed corynebacterium parvum into the lung, and cells obtained following instillation of quartz. none of the populations showed any evidence o ... | 1988 | 2843464 |
| release of tumor necrosis factor-alpha from macrophages. enhancement and suppression are dose-dependently regulated by prostaglandin e2 and cyclic nucleotides. | pge2 has previously been shown to suppress various leukocyte functions. in this study, we examined whether pge2 would affect release of tnf-alpha from rat resident peritoneal macrophages. two different, dose-dependent effects were observed: low pge2 concentrations (0.1 to 10 ng/ml) stimulated, whereas higher concentrations (greater than 10 ng/ml) suppressed tnf-alpha release. pge2-stimulated tnf-alpha production was dependent on de novo protein synthesis and was associated with an intracellular ... | 1988 | 2844899 |
| effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages. | reactive oxygen intermediates released by activated hepatic macrophages have been implicated in the pathogenesis of a rat model of liver injury induced by sequential administration of corynebacterium parvum and endotoxin. in this model, c. parvum causes extensive infiltration of the liver with activated macrophages, but severe liver injury occurs only after subsequent exposure to endotoxin. we have therefore investigated the effects of endotoxin on the release of reactive oxygen intermediates by ... | 1988 | 2846404 |
| a host-vector system for an arthrobacter species. | an efficient host-vector system has been developed for an industrial strain of arthrobacter sp. (nrrl b3728)used for glucose isomerase production. protoplasts of arthrobacter were generated by treating the cells with 0.5 mg lysozyme ml(-1) for 60 min in a solution containing 0.5 m-sucrose. around 30% of the protoplasts regenerated on agar containing 0.5 m-sodium succinate as osmotic stabilizer. three hybrid vectors, pbl2100, pcg1100 and pcg2100, were constructed by combining the escherichia coli ... | 1988 | 2846755 |
| influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines. | sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ... | 1988 | 2847397 |
| the effect of selected viruses on corynebacterium kutscheri infection in rats. | the influence of selected viral pathogens on rats that were previously infected with corynebacterium kutscheri was investigated. a series of three separate experiments were performed to test the effect of sialodacryoadenitis virus, sendai virus and rat virus. in each experiment, weanling rats were divided into three groups (c. kutscheri-inoculated, virus-inoculated and c. kutscheri plus virus-inoculated). two groups were inoculated oronasally with c. kutscheri to establish subclinical infections ... | 1988 | 2848153 |
| impairment of macrophage antiviral activity by soluble tumor products. effects of bacterial immunomodulators. | the antiviral activities of normal rat peritoneal macrophages versus herpes simplex virus type 1 were inhibited by sera from tumor-bearing rats and 3m kcl extracts of tumor mass. the inhibitory activity was demonstrated on the extrinsic as well as on the intrinsic macrophage functions. sera from corynebacterium parvum and listeria monocytogenes treated tumor bearing rats did not inhibit these macrophages functions. furthermore the 3 m kcl extracts from the tumor mass of the above treated tbr sho ... | 1988 | 2856293 |
| adhesion of corynebacterium pilosum by pili to epithelial cells of bovine vulva. | piliated (p+) and nonpiliated (p-) clones of corynebacterium pilosum were selected, and their adhesion to the epithelial cells of the bovine vulva and vaginal vestibule was examined. the number of p+ bacteria of c pilosum that adhered to vulval epithelial cells was greater than that of p- bacteria. the adhesion of p+ bacteria, but not p- bacteria, to the epithelial cells was inhibited by the antipilus antiserum; therefore, the adhesion of c pilosum to the epithelial cells of the vulva was primar ... | 1985 | 2859821 |
| adverse effect of intrapleural corynebacterium parvum as adjuvant therapy in resected stage i and ii non-small cell carcinoma of the lung. ludwig lung cancer study group. | intrapleural corynebacterium parvum 7 mg or placebo was administered postoperatively as adjuvant therapy to patients with resected stage i and ii non-small cell lung cancer in a prospective, randomized, multicenter trial. a total of 475 patients were entered into this study between july, 1977, and february, 1979. of this group, 405 can be evaluated, with an average follow-up time of 4.6 years. more side effects, especially fever and chest pain, were observed in patients receiving corynebacterium ... | 1985 | 2860271 |
| the involvement of dendritic cells in the handling of the immune stimulant c. parvum. a morphological investigation using immunoperoxidase techniques. | in earlier experiments we showed that locally administered corynebacterium parvum (c. parvum) stimulated the t-cell system and had a beneficial effect on the recurrence rate of surgically resected cancers of the uterine cervix. in this paper we report the use of an immunoperoxidase technique to trace c. parvum antigen in the draining lymph nodes. in a guinea pig model the popliteal lymph node was studied after the injection of 70 micrograms of c. parvum in the hind footpad. at 6 h, intact bacter ... | 1985 | 2861687 |
| diphtheria toxin. effect of substituting aspartic acid for glutamic acid 148 on adp-ribosyltransferase activity. | photoaffinity labeling experiments with diphtheria toxin fragment a have implicated glutamic acid 148 as a constituent of the nad binding site. to evaluate the role of this residue in adp-ribosylation of elongation factor 2, we replaced it with aspartic acid by in vitro mutagenesis of a toxin gene fragment cloned in escherichia coli. fragment a containing aspartic acid at position 148 had less than 0.6% the adp-ribosylation activity of wild-type fragment a. the mutation produced no change in sen ... | 1985 | 2863266 |
| vaccines and immunization schedules. | a simplified schedule, applicable in developing countries, has been tested for diphtheria, tetanus and pertussis (dtp) and polio immunization. it comprised two injections, six months apart starting at the age of 3 to 8 months. dtp and inactivated polio (ipv) vaccines of special composition and live measles vaccine given at the age of 9 to 14 months induced a good antibody response. special attention is being given to pertussis immunity. although low agglutination titers may sometimes be found, d ... | 1985 | 2866613 |
| [adhesion in corynebacterium diphtheriae]. | the study of 8 c. diphtheriae strains of different origin revealed that these strains were capable of inducing the agglutination of trypsinized sheep red blood cells (srbc). toxigenic strains gravis isolated from diphtheria patients were more active in their adhesion to srbc than toxigenic strains gravis isolated from carriers. the latter were, in their turn, more active than nontoxigenic strains mitis. no fimbriae were detected on the cell surface by electron microscopy. | 1985 | 2868590 |
| [antibody response to the fractionated administration of the 2d or 3d basic vaccination injection with a mixed vaccine against diphtheria, tetanus and pertussis]. | | 1986 | 2872973 |
| intrapleural and intravenous corynebacterium parvum in patients with resected stage i and ii non-small cell carcinoma of the lung. the ludwig lung cancer study group. | a prospective randomized trial compared the administration of intrapleural plus intravenous corynebacterium parvum (c. parvum) versus placebo in patients with resected stage i and stage ii non-small cell bronchogenic carcinoma. treatment consisted of 7 mg c. parvum injected into the pleural space and 7 mg c. parvum intravenously once between days 6 and 12 postoperatively and 7 mg intravenously every 3rd month during the 1st year. intrapleural administration of 35 cc of saline served as the place ... | 1986 | 2876772 |
| [reactogenic properties of a dtp vaccine with a reduced antigen dosage]. | the reactogenic properties of batches of adsorbed dpt vaccine with the normal content of antigens and with the content of diphtheria and tetanus toxoids reduced, respectively, to 10 lf and 5 bu per immunization dose have been studied under the conditions of a controlled epidemiological trial. the reduced antigenic content of adsorbed dpt vaccine decreased the number of vaccinal reactions 1.8 times, as well as the intensity of their manifestations. | 1986 | 2879401 |
| [comparative immunologic effectiveness of variants of the dtp vaccine]. | the immunological effectiveness of two batches of adsorbed dpt vaccine, the batch with the normal content of antigens (control) and the batch with the content of diphtheria and tetanus toxoids reduced to 20 lf/ml and 5 bu/ml respectively (test batch), has been studied under the conditions of controlled trial. as a result, the reduction of the antigenic content of adsorbed dpt vaccine has been found to exert no negative influence on the immunological effectiveness of the diphtheria, tetanus, and ... | 1986 | 2879402 |
| [the epidemic process of diphtheria and pertussis with active immunization of a pediatric population]. | the heterogeneity of humans in their immune response to the components of adsorbed dpt vaccine is shown. improvements in the organizational forms of immunoprophylaxis are necessitated. | 1986 | 2879404 |
| protection of mice against intestinal amoebiasis with bcg, corynebacterium parvum and listeria monocytogenes. | treatment with corynebacterium parvum or bcg, or infection with live listeria monocytogenes was found to protect mice against subsequent infection with entamoeba histolytica. complete protection was obtained in mice treated with 10(7) (colony forming units) of bcg but not with 10(5). partial protection was achieved with 10(6) of bcg. these data provide evidence that non-specific immunity plays an important role in the host defense against amoebic infection. | 1986 | 2880331 |
| lack of adjuvant effect of the pertussis component on ipv dtp-polio vaccine in children. | on day 0, four groups of children (3 to 6 months old) randomly received ipv alone or ipv + pertussis, or ipv + dp, or ipv + dtp. at days 28 and 56, all the children received the same ipv + dtp vaccine. polio neutralizing and diphtheria antibodies were determined at days 0, 28 and 56. no adjuvant and even some inhibitory effect of pertussis was observed at days 28 and 56 on mean polio antibody titers. these results are compared to those observed with diphtheria. | 1986 | 2881819 |
| simultaneous administration of diphtheria/tetanus/pertussis/polio vaccine and hepatitis b vaccine in a simplified immunization programme. | in most developing countries hepatitis b virus is endemic and prevention has to be carried out early in life and on a mass scale. in these regions, simultaneous administration of multiple antigens is normal practice. we have therefore, investigated the interaction of hepatitis b vaccine with dtp-polio vaccine. studies include the immune response post one and two injections to diphtheria and tetanus toxoid, pertussis and hepatitis b surface antigen. the vaccines were given simultaneously or not a ... | 1986 | 2881821 |
| [regulation of corynebacterium pekinense glutamine synthetase by the carbon and nitrogen source]. | | 1986 | 2883774 |
| bacterial pharyngitis. | | 1987 | 2884373 |
| haemagglutinating and hydrophobic properties of corynebacterium (eubacterium) suis. | | 1986 | 2886018 |
| comparison of experimental infection in mice of corynebacterium renale piliated and non-piliated clones. | | 1987 | 2887685 |
| comparison of susceptibility to phagocytosis by mouse peritoneal macrophages between corynebacterium renale piliated and non-piliated clones. | | 1987 | 2887686 |
| mechanism of decline of natural killer cell activity in corynebacterium parvum-treated mice: inhibition by erythroblasts and thy 1.2+ lymphocytes. | injection of (c57bl/6 x dba/2)f1 mice with corynebacterium parvum (cp), iv, resulted in a depression of splenic natural killer (nk) cell activity 7-17 days after treatment. this decline in reactivity was accompanied by an increase in splenic tumor-binding cells and a decrease in cytotoxic tumor-binding cells as evaluated in a single-cell assay. morphologic analysis indicated that the increased tumor-binding cells following cp injection were due to erythroblasts binding to yac-1 tumor cells. with ... | 1987 | 2887687 |
| [observation of the serological effect and immune resistance of 2-dose immunization with adsorbed dtp]. | | 1987 | 2888535 |
| comparison of surface hydrophobicity of piliated and non-piliated clones of corynebacterium renale and corynebacterium pilosum. | piliated (p+) and non-piliated (p-) clones of corynebacterium renale and c. pilosum were similar in hydrophobicity as measured by hydrophobic interaction chromatography, bacterial adherence to hydrocarbons and the salt aggregation test. therefore, the previously reported adherence of p+ clone to various cells, which is more effective than that of p- clone, may be uncorrelated with the degree of hydrophobicity of both clones of these bacteria. hydrophobicity of p+ and p- clones was found to be hi ... | 1987 | 2889288 |
| corynebacterium diphtheriae in the environment of carriers and patients. | a total of 533 throat and nasopharyngeal cultures were obtained from 328 staff who nursed cases of diphtheria and carriers of corynebacterium diphtheriae; none yielded c. diphtheriae. only one out of 189 environmental samples relating to 22 patients and carriers was positive. in addition, one carrier with chronic skin disease was found to have widespread colonization with c. diphtheriae. several samples both from his hospital room and home yielded c. diphtheriae, indicating that he was a 'disper ... | 1987 | 2891757 |
| population shift from piliated to non-piliated bacteria in kidneys, bladder and urine of mice infected with corynebacterium renale strain no. 115 piliated bacteria. | | 1987 | 2892960 |
| [restriction analysis of the dna of the toxigenic corynephages bf, phi 984, phi 9 and c]. | the results of restriction analysis of toxigenic corynephages bf, phi 984, phi 9, and c are presented. phage bf was shown to be a deletion derivative of phage beta vir, phage phi 984 to be omega-like. toxigenic corynephages phi 9 and c belong to a new group of corynephages designated phi. dna of phages phi 9 and c as well as chromosomal dna of the indicator strains was not hydrolysed by specific hind iii endonuclease, that is likely to be associated with the presence of a modification system in ... | 1987 | 2893490 |
| phagocytosis of piliated and non-piliated corynebacterium renale by murine polymorphonuclear leukocytes. | | 1988 | 2896261 |
| jk coryneforms: a continuing problem for hospital infection control. | control of nosocomial infection is complicated by emergence of endogenous flora as nosocomial pathogens. the jk group of diphtheroids (coryneforms) exemplify this problem. infection with these organisms is frequent in certain segments of the hospital population and is associated with procedures as well as drug therapy. a number of factors suggest that cross-infection due to jk coryneforms may become even more prominent in the future. development of rational control measures will require attentio ... | 1988 | 2896733 |
| antibody level of new zealand children immunized with the triple vaccine dtp (diphtheria-tetanus-pertussis). | enzyme-linked immunosorbent assay (elisa) tests were used to measure igg antibody levels in 2638 new zealand children who had been immunized with the triple vaccine dtp. the percentage of children immune to diphtheria decreased with age. the percentage of children immune to tetanus varied from 67.1 to 55.0%. the percentage of children with measurable antibody to pertussis increased with age. the mean percentages of children with measurable antibody or immunity to one or more dtp components were ... | 1988 | 2903065 |
| population shift between piliated and non-piliated bacteria in various culture conditions of corynebacterium renale. | | 1988 | 2907765 |
| diphtheria-related peptide hormone gene fusions: a molecular genetic approach to chimeric toxin development. | there has been considerable effort in chemically conjugating a variety of plant and bacterial toxins to monoclonal antibodies that are directed to surface antigens on target cells. coupling has been mediated through disulfide linkage, and the resulting conjugates are known generically as immunotoxins. in general, there are a few shortfalls to this approach. for example, since it is clear that not all surface antigens are internalized, one cannot predict the fate of a given it once bound to its d ... | 1988 | 2908622 |