| effects of stimulated or immunologically activated macrophages on the induction of immune responses to listeria monocytogenes. | the influences of peritoneal macrophages induced by proteose peptone, corynebacterium parvum (c. parvum) or bacillus calmette guérin (bcg) on the initiation and development of immune responses and protection against listeria monocytogenes infection were studied in mice. mice treated intraperitoneally (i.p.) with proteose peptone 4 days previously showed much the same level of protection against an intraperitoneal infection with listeria as untreated mice. mice treated i.p. with c. parvum 4 days ... | 1990 | 2345013 |
| inducible cytosolic enzyme activity for the production of nitrogen oxides from l-arginine in hepatocytes. | the in vivo conditions needed for the induction of nitrogen oxide synthesis by hepatocytes were determined. hepatocytes obtained from rats injected with killed corynebacterium parvum spontaneously produced no2(-)+no3- in culture and were found to contain cytosolic enzyme activity for nitrogen oxide synthesis. the enzyme activity required both l-arginine and nadph, and was not found in hepatocytes obtained from normal rats or rats injected with lipopolysaccharide (lps) alone. in contrast, nonpare ... | 1990 | 2346476 |
| trichomycosis axillaris. | | 1990 | 2347977 |
| changes in ovine erythrocyte morphology due to sphingomyelin degradation by corynebacterium pseudotuberculosis phospholipase d. | corynebacterium pseudotuberculosis produces a sphingomyelin-specific phospholipase d exotoxin that is a major determinant in the pathogenesis of caseous lymphadenitis. we assessed the changes induced in the morphology and sphingomyelin concentration of ovine erythrocytes after incubation with broth culture filtrates or purified exotoxin. sphingomyelin was hydrolysed nearly in parallel with shape change. morphologically, spherostomatocytes were seen initially, and later these contained numerous v ... | 1990 | 2348780 |
| endocapsular hypopyon: a clinical sign of localized endophthalmitis. | chronic intraocular infection following cataract extraction and intraocular lens (iol) implantation has been documented by several authors. we report a case of chronic, bacterial endophthalmitis that clinically correlates with previous pathologic studies in which the focus of infection was sequestered in the capsular sac between the iol and the posterior lens capsule. successful management did not require iol removal. | 1990 | 2348973 |
| contrasting evolutionary histories of chloroplast thioredoxins f and m. | fourteen thioredoxin sequences were used to construct a minimal phylogenetic tree by using parsimony. the bacterial thioredoxins clustered into three groups: one containing the photosynthetic purple bacteria, escherichia and corynebacterium; a second containing the photosynthetic green bacterium, chlorobium; and a third containing cyanobacteria. these groupings are similar to those generated from earlier 16s rna analyses. animal thioredoxins formed a fourth group. the two thioredoxins of chlorop ... | 1990 | 2359363 |
| unusual pathogens in narcotic-associated endocarditis. | we report the cases of three adults with a history of intravenous drug abuse who developed endocarditis caused by corynebacterium xerosis, neisseria subflava, and neisseria flavescens, respectively. no cases of endocarditis caused by c. xerosis or n. flavescens and only one case caused by n. subflava have previously been reported in association with narcotic addiction. the prominent clinical features in all patients included poor response to antibiotic therapy, persistent fever, and major emboli ... | 1990 | 2359905 |
| vaccination of humans against cutaneous leishmaniasis: cellular and humoral immune responses. | brazilian army conscripts were vaccinated against american cutaneous leishmaniasis by using nonliving polyvalent promastigote leish vaccine 5 or leish vaccine 6 (vaccines with five or six leishmania stocks) with or without corynebacterium parvum. no statistically significant differences in lymphocyte stimulation indices were found between vaccinated groups with or without c. parvum, but lymphocyte stimulation indices of all vaccinees were significantly higher (p less than 0.001) than those of th ... | 1990 | 2365458 |
| caseous lymphadenitis: a cause for concern. | | 1990 | 2368302 |
| alterations in the phospholipid composition and morphology of ovine erythrocytes after intravenous inoculation of corynebacterium pseudotuberculosis. | corynebacterium pseudotuberculosis produces a sphingomyelin-specific phospholipase d exotoxin that is a major determinant in the pathogenesis of caseous lymphadenitis. the effect of this exotoxin on erythrocytes was assessed during experimentally induced infection of sheep. blood was drawn at timed intervals, and the phospholipid composition of erythrocytes was determined by use of high-performance liquid chromatographic analysis of membrane extracts. erythrocyte morphology was determined by use ... | 1990 | 2368943 |
| coryneform endophthalmitis. two case reports. | recent clinical studies have emphasized the importance of diphtheroids, previously regarded as nonpathogenic bacteria or contaminants, as causes of ocular disease. we encountered two patients with endophthalmitis following cataract extraction and anterior chamber intraocular lens implantation. both patients had previously been treated with subconjunctival and/or oral corticosteroids for presumed sterile endophthalmitis. vitreous cultures in each case yielded pure growth of a diphtheroid that was ... | 1990 | 2369352 |
| selective medium for isolating arcanobacterium haemolyticum. | | 1990 | 2380412 |
| intralesional immunotherapy of brain tumors with combined corynebacterium parvum and recombinant interleukin-2 in mice. | clinical observations and experimental work suggested that inflammatory cells attracted to the brain exert a nonspecific antineoplastic effect. intralesional treatment of implanted malignant murine brain tumors (kht sarcomas) with killed corynebacterium parvum produced an inflammatory cell infiltrate and increased survival in c3h mice relative to that in untreated control c3h mice. this antitumor effect was enhanced when recombinant interleukin-2 was sequentially added as a second intralesional ... | 1990 | 2380991 |
| endocarditis associated with prosthetic cardiac valves. | clinical features, microbiology, therapy and outcome of 26 episodes of prosthetic valve endocarditis occurring at westmead hospital from 1979 to 1989 were examined retrospectively. presentation with a new or changed cardiac murmur was associated with early onset infection (within 12 months of prosthetic valve insertion; p = 0.0033). corynebacteria were the commonest cause of early onset endocarditis (4 of 11 episodes) and streptococcus viridans of late onset endocarditis (4 of 15 episodes). nine ... | 1990 | 2381336 |
| the auckland skin clinic tinea pedis and erythrasma study. | three hundred consecutive patients attending the auckland hospital dermatology clinic were examined clinically and microbiologically for evidence of interdigital or plantar mycological or bacterial infection. one hundred and nine patients were shown by laboratory investigation to have an infection. of these, only 89 displayed clinical signs of infection. erythrasma, a desquamative condition caused by corynebacterium minutissimum, was the commonest infection in this study. the commonest dermatoph ... | 1990 | 2385417 |
| undetected diabetes and the plastic surgeon. | plastic surgery candidates are generally healthy. therefore, major postoperative complications are rare. should they happen, the surgeon should search for possible causes, one of which is undetected diabetes mellitus. six patients are presented who, based on the individual or family history or the unusual nature of their complications, were suspected of having diabetic tendencies. this experience necessitated our in-depth search into the role of silent or undetected diabetes. this report emphasi ... | 1990 | 2385665 |
| corynebacteria as urinary pathogens. | | 1990 | 2388006 |
| microflora associated with the skin of the bowhead whale (balaena mysticetus). | a study of the microbiological flora isolated from cultures of normal and lesional skin tissue samples collected from 19 bowhead whales (balaena mysticetus) over a 4 yr period is presented. these cultures were obtained from 30 tissue samples (17 normal, 13 lesion) and 248 swab samples (157 normal, 91 lesion). seven hundred-thirty bacterial and yeast isolations were made (285 normal, 445 lesion). distribution revealed that 56% of the gram positive bacterial isolates, 75% of the gram negative bact ... | 1990 | 2388358 |
| [corynebacterium group d2: its role in human infectious pathology]. | | 1990 | 2389536 |
| what is your diagnosis? mineralized retropharyngeal mass (3 x 5 cm) compressing the pharynx ventrally. | | 1990 | 2391280 |
| characterization and partial purification of l-asparaginase from corynebacterium glutamicum. | a high l-asparaginase (l-asparagine amidohydrolase: ec 3.5.1.1) activity was found under conditions of lysine overproduction in cultures of corynebacterium glutamicum. l-asparaginase was purified 98-fold by protamine sulphate precipitation. deae-sephacel anion exchange, ammonium sulphate precipitation and sephacryl s-200 gel filtration. the asparaginase protein was subjected to page under non-denaturing conditions, identified by an in situ reaction and eluted from the gel in an active form. the ... | 1990 | 2391490 |
| characterization of phi ga1, an inducible phage particle from brevibacterium flavum. | eighteen related strains of arthrobacter, brevibacterium and corynebacterium were used as indicator strains in an attempt to isolate corynephages from a large number of soils and from waste-water samples. although no phages capable of producing plaques were isolated, one of the indicator strains used, brevibacterium flavum atcc 14067, was lysogenic for the inducible phage phi ga1. this phage was not observed to form plaques on any of the strains tested. phi ga1 is of b1-morphotype with a linear ... | 1990 | 2391491 |
| corynephage cog, a virulent bacteriophage of corynebacterium glutamicum, and its relationship to phi ga1, an inducible phage particle from brevibacterium flavum. | the host range of the virulent bacteriophage cog among several strains of amino acid-producing corynebacteria is limited to corynebacterium glutamicum lp-6. cog is a typical corynephage of the siphoviridae family (b1 morphotype) with an isometric head of 52 nm and a medium length, striated tail of 190 nm. it has a linear genome of 39.7 kb with cohesive ends and 53% g + c; a restriction map is presented, including regions of dna homology (by hybridization) with the inducible phage particle phi ga ... | 1990 | 2391495 |
| infections due to corynebacterium group d2. report of a case. | corynebacterium group d2 is a gram-positive bacillus easily identified in clinical microbiology laboratories. however, this organism is often disregarded as a skin and mucous contaminant. the spanish literature has recently described corynebacterium group d2 as a urinary pathogen in a specific patient population. we report a case of corynebacterium group d2 infection to illustrate the potential pathogenicity and clinical presentation of infection due to this organism in the united states. | 1990 | 2393330 |
| anti-tumor protection induced in mice by fatty acid conjugates: alkyl butyrates and poly(ethylene glycol) dibutyrates. | simple fatty acids, especially butyrate salts, have interesting biological properties, since they are able to down-regulate cell growth and promote various differentiated cellular functions. their use for anti-tumor treatment is, however, hampered by their over-rapid diffusion in the blood, followed by a short-lived biological action. we have therefore devised conjugates linking butyrate with either (i) aliphatic alcohols of increasing carbon numbers ranging from c4 to c12 or (ii) poly(ethylene ... | 1990 | 2394513 |
| [a clinical study of bacteremia in urology]. | we investigated 32 patients with bacteremia that occurred in the department of urology, school of medicine, kanazawa university between april, 1983 and march, 1989. this incidence represented 1.9% of the total number of inpatients. the study group comprised 29 males and 3 females, and their age varied from 25 to 82 years with a mean age of 61.7 years. twenty-two (75%) of the 32 patients had urologic malignancies. the majority of patients were compromised hosts who had one or more (average, 3.8) ... | 1990 | 2401814 |
| cloning and expression of the phospholipase d gene from corynebacterium pseudotuberculosis in escherichia coli. | a toxic phospholipase d (pld) is putatively involved in pathogenesis of corynebacterium pseudotuberculosis infections. we report here the cloning and expression of the pld gene (pld) in escherichia coli. a cosmid library of dna from c. pseudotuberculosis biovar ovis isolate whetten 1 was constructed and screened for pld-producing recombinants by plating them on lb agar containing sheep erythrocytes and equi factors. one recombinant, designated pcpo1, yielded a gene product which displayed synerg ... | 1990 | 2403529 |
| hypertrophic osteopathy in a dog with a chronic lung abscess. | a 2-year-old dog was examined because of gradual lameness of all 4 limbs and weight loss. hypertrophic osteopathy was diagnosed. radiography revealed a mass in the caudal lobe of the right lung. at necropsy, the mass was determined to be a chronic abscess. corynebacterium pyogenes was cultured from the lesion. although hypertrophic osteopathy in dogs is commonly associated with a thoracic lesion, most often neoplastic, the chronic lung abscess in this dog might have been formed as a result of a ... | 1990 | 2407705 |
| cloning, nucleotide sequence, and expression in escherichia coli of the phospholipase d gene from corynebacterium pseudotuberculosis. | the phospholipase d (pld) gene from corynebacterium pseudotuberculosis has been cloned, sequenced, and expressed in escherichia coli. analysis of dna sequence data reveals a major open reading frame encoding a 31.4-kilodalton protein, a size consistent with that estimated for the pld protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. comparison of these data with the amino-terminal protein sequence indicates that the mature pld protein is preceded by a 24-residue signal sequen ... | 1990 | 2407718 |
| attempts to correlate interferon induction and activation of natural killer cells by corynebacterium parvum. | intraperitoneal (i.p.) injection of poly i:poly c resulted in high interferon titers in the peritoneal wash fluid and in the serum of mice, which was maximal at 4 to 6 h after injection. in contrast, no interferon could be measured in the peritoneal fluid at various times after injection of c. parvum. also, all attempts to induce serum interferon by c. parvum were unsuccessful. however, both poly i:poly c and c. parvum were causing the activation of natural killer (nk) cells in the cell populati ... | 1985 | 2408996 |
| interferon inducibility in mice treated with corynebacterium parvum. | mice were given single intraperitoneal (i.p.) injections of corynebacterium parvum, followed, after different time intervals, by i.p. injections of the interferon inducers polyinosinic-polycytidylic acid (poly-i:poly-c), 10-carboxymethyl-9-acridanone (cma) or herpes simplex virus. with all three inducers production of interferon in the peritoneal cavity was enhanced in c. parvum-pretreated mice. production of circulating interferon in c. parvum-pretreated mice was enhanced with cma and depressed ... | 1985 | 2409917 |
| the involvement of omentum and its milky spots in the dynamics of peritoneal macrophages. | the investigation has been carried out on stimulated and unstimulated peritoneal cavities of rats. china ink and corynebacterium parvum were injected i.p. both as peritoneal stimuli and markers. omenta were picked up at time intervals beginning with 10 min and up to seven days after the i.p. injection. the light and electronmicroscopic investigation showed after 10-30 minutes labeled macrophages stuck as monolayers on some peritoneal areas corresponding to the milky spots which developed in size ... | 1985 | 2410786 |
| binding of alpha 2-macroglobulin and haptoglobin to actinomyces pyogenes. | all 25 cultures of actinomyces pyogenes tested in the present study bound 125i-labelled human alpha 2-macroglobulin with a mean binding of 65.6%. thirteen cultures also bound 125i-labelled human haptoglobin with a mean of 51.5%. none interacted with fibrinogen, fibronectin, immunoglobulin g, or albumin. twenty-eight cultures representing other species of actinomycetaceae did not show any interaction with alpha 2-macroglobulin, haptoglobin, and other plasma proteins tested. the binding of alpha 2 ... | 1985 | 2411371 |
| characterization of the diphtheria tox transcript in corynebacterium diphtheriae and escherichia coli. | transcription of the tox gene in lysogenic corynebacterium diphtheriae strains c7(beta tox+), c7 (gamma tox) and the hypertoxigenic pw8 (omega tox+) was analyzed and compared with transcription of the c. diphtheriae tox gene in the recombinant strain escherichia coli (pdt201). in all cases s1 nuclease mapping localized the 5' terminus of the tox mrna to a site 8 or 9 base pairs (bp) downstream of a region similar to the -10 consensus sequence of e. coli promoters. in c. diphtheriae the tox trans ... | 1985 | 2411714 |
| adoptive immunotherapy of a newly induced sarcoma: immunologic characteristics of effector cells. | a newly induced syngeneic transplantable sarcoma, mca 105, was used for studies of the biologic characteristics of fresh noncultured and secondarily in vitro sensitized (ivs) cells with antitumor reactivity. fresh spleen cells harvested from mice immunized to the mca 105 tumor by a mixture of viable tumor cells and corynebacterium parvum exhibited no detectable cytotoxic activity to mca 105 tumor targets in a 4-hr chromium-release assay, and adoptive transfer of these cells mediated the specific ... | 1985 | 2411817 |
| immunomodulators and allergy. | the role played by immunomodulation in allergy is critically reviewed. the prospective mechanisms of immunomodulation, specifically including those showing relation with allergic phenomena, are taken into consideration, examining the main interfering factors. type i, ige-mediated immunoreaction, in its two aspects, ige synthesis and mediator's release, is analyzed, bearing in mind some agents involved or affecting these processes, mimicking immunomodulation. other agents, such as corynebacterium ... | 1985 | 2412571 |
| importance of coordinated immune stimulation in experimental antitumor treatment. | we have proposed an antitumor therapeutic model in mice grafted with crocker 180tg cells. the treatment strategy involves a coordinated immune stimulation which should always precede treatment of target cells. potent stimulators mobilizing the majority of immune competent cells can be injected only once since repetition results in adverse effects on the response. thus, to circumvent this difficulty, we propose the amplification, after a single shot of corynebacterium parvum extract, of the immun ... | 1985 | 2412978 |
| [blood tellurite media using aminopeptide with an expired period of usefulness for indication of corynebacterium diphtheriae]. | | 1985 | 2414559 |
| antimicrobial activity of various immunomodulators: independence from normal levels of circulating monocytes and natural killer cells. | the effects of 89sr treatment on the natural host resistance of cd-1 mice and the enhancement of resistance by immunomodulators to infection with listeria monocytogenes or herpes simplex virus type 2 (hsv-2) were determined. in the cd-1 mouse, single-dose treatment with 89sr caused a profound decrease in the number of circulating monocytes (mo), lymphocytes, and polymorphonuclear leukocytes (pmn) within 1 week. there was also marked functional impairment of the mo inflammatory response, as well ... | 1986 | 2416693 |
| evaluation of corynebacterium granulosum derived p40 fraction effects on macrophage anti-herpes simplex virus type 1 functions. | | 1985 | 2417550 |
| whipple's disease with unusual clinical, bacteriologic, and immunologic findings. | a middle-aged man was found to have whipple's disease after episodes of nephritis and arthralgia. while on antibiotic therapy, and in the absence of worsening of the histologic appearances of the jejunum, aortic valve endocarditis developed, presumably due to whipple's disease. observations during the course of his illness included the isolation of corynebacterium bovis from an inguinal lymph node, and detection of circulating antibodies against material within the characteristic abnormal macrop ... | 1986 | 2420678 |
| prevalence of minor udder pathogens after intramammary dry treatment. | a total of 156 dairy cows was randomly assigned to one of four groups at drying off over an 18-mo period: untreated control or intramammary treatment of each mammary quarter with either 400 mg novobiocin, 300 mg cephapirin, or 1 g dihydrostreptomycin with 1 million units penicillin. quarter foremilk samples were aseptically collected from each cow within 1 mo of drying off and within 1 mo after parturition for bacteriological analysis. prior to drying off, 28.7% of quarters were positive of whic ... | 1986 | 2423568 |
| [microbial pathogenesis of whipple's disease]. | in a case of whipple's disease with electron microscopic demonstration of rod-shaped bacteria we could isolate propionibacterium acnes (former name: corynebacterium anaerobium), actinomyces, and lactobacillus from duodenal biopsies by the aid of modern anaerobic culture technique. simultaneously we found a dysbiosis (increase of anaerobic coca and anaerobes) in du odenal juice. after antibiotic treatment propionibacterium and lactobacillus disappeared and an other type of dysbiosis (appearance o ... | 1986 | 2424711 |
| comparison of the effect of antibiotic dry cow teat canal and intramammary dry cow therapy of dairy cows on the prevalence of teat canal and intramammary infections at calving. | the specific therapy of bacterial colonization of the teat canals of dried-off dairy cows by means of small amounts (33 mg/0.25 ml and 14 mg/0.1 ml) of a procain benzyl penicillin-dihydrostreptomycin sulphate combination has been investigated. of 36 teat canals treated with 0.25 ml antibiotic preparation each, 24 (66.6%) were infected at the beginning of the dry period, whereas at its termination only 7 (19.4%) showed bacteriologically positive swab cultures. by treating a further 43 quarters wi ... | 1985 | 2425091 |
| relationship between the tuberculin-type and jones-mote-type hypersensitivities: suppression of basophil infiltration by mycobacterial adjuvant. | guinea-pigs immunized with bovine gammaglobulin (bgg) in incomplete freund's adjuvant (ifa) showed the typical jones-mote-type hypersensitivity (jmh) reaction when tested 5 days later. this is characterized by prominent basophil infiltration. after pretreatment with complete freund's adjuvant (cfa) 16 days before immunization with bgg in ifa, the lesions resembled the jmh reaction macroscopically in their evolution over time and in the absence of a positive macrophage migration inhibition (mit) ... | 1986 | 2426184 |
| aspartate-assisted immune stimulation: its importance in antitumor and antiviral protection. | immune stimulators such as corynebacterium parvum (cp) are useful for antitumoral and antiviral therapy. however, the immune trigger cannot be reactivated without adversely affecting the disease. we have tried to amplify the results yielded by a single injection of cp by using either interleukin-2 (il2) or aspartate salts (asp). in the present report, we show that il2 has no detectable clinical effect. in contrast, the addition of an asp salt increases the antiviral and antitumoral protection af ... | 1986 | 2426209 |
| interferon-mediated protection of b16 melanoma cells from cytotoxicity by activated macrophages. | corynebacterium parvum-activated macrophages (m phi), purified by adherence, were cytotoxic for b16 melanoma cells maintained in vitro. pretreatment of the melanoma cells for 18 hr with interferon-alpha/beta or -gamma (ifn-alpha/beta or -gamma) caused a reduced susceptibility of the b16 cells to m phi-mediated cytotoxicity. the ifn-induced protective effect of b16 cells from cytotoxic m phi was found to be dose dependent. in addition, ifn-gamma was more protective than ifn-alpha/beta. the protec ... | 1986 | 2427205 |
| soluble amoebicidal factors mediate cytolysis of naegleria fowleri by activated macrophages. | murine peritoneal macrophages activated in vivo with corynebacterium parvum or bacille calmette-guérin, in contrast to resident macrophages, demonstrated significant cytolysis of the amoeba, naegleria fowleri. catalase and superoxide dismutase, both alone and in combination, failed to inhibit cytolysis of amoebae. n. fowleri amoebae demonstrated significant resistance to exogenously added hydrogen peroxide. the hydroxyl radical scavengers mannitol, thiourea, and dimethyl sulfoxide, as well as an ... | 1986 | 2427211 |
| [a method of determining the toxicity of corynebacterium diphtheriae]. | | 1986 | 2429062 |
| whipple's disease of the central nervous system in aids. | | 1986 | 2429182 |
| biological, chemical, immunological and staining properties of bacteria isolated from tissues of leprosy patients. | two kinds of microorganisms are found in tissue of leprosy patients: mycobacterium leprae (ml) and leprosy derived corynebacteria (ldc). ml from untreated patients has an alcohol-acid-fastness, which is lost upon treatment with antibiotics and immune response (tuberculoid leprosy). vulnerable ml thus produced can be reversibly de-stained by organic solvent: in tissue sections from tuberculoid and treated patients, more bacteria are, thus, revealed by the wade-fite than by the ziehl-neelsen proce ... | 1985 | 2429862 |
| [comparative studies of the immunostimulating (paramunizing) effectiveness of bcg, levamisole, corynebacterium parvum and preparations of pock viruses in various in vivo and in vitro tests]. | | 1986 | 2430381 |
| corynebacterium parvum in malignant pleural effusion. a randomized prospective study. | in a randomized trial, pleurodesis was attempted with corynebacterium parvum in one group and bleomycin in another. patients with malignant pleural effusion which required repeated drainage were treated with instillation of one of these agents after complete drainage of the pleural effusion. there were 32 patients who could be evaluated. sixty-five per cent of the patients treated with c. parvum had no recurrence after one treatment and another 29% after two treatments. in the bleomycin group, t ... | 1986 | 2430825 |
| prolongation of survival of mice bearing the eb and esb lymphoma by treatment with interferon inducers alone or in combination with corynebacterium parvum. | the objective of this study was to evaluate if pretreatment with corynebacterium parvum (c. parvum) augments the effects of interferon (ifn) inducers on survival of dba/2 mice transplanted with two syngeneic lymphoma variants, the low metastatic eb and the high metastatic esb tumor. the involvement of ifn in the treatment effects was investigated. as inducers of ifn-alpha/beta newcastle disease virus (ndv), polyinosinic-polycytidylic acid (polyi:polyc), and 10-carboxymethyl-9-acridanone (cma) we ... | 1986 | 2431778 |
| isolation and characterization of monoclonal antibodies against pili of corynebacterium renale and corynebacterium pilosum. | five monoclonal antibodies against pili of corynebacterium renale 115 p+ (piliated clone) and two monoclonal antibodies against pili of c. pilosum 92 p+ (piliated clone) were produced. these antibodies bound to pili of the homologous strain in in enzyme-linked immunosorbent assay (elisa) and agglutinated p+ but not p- (non-piliated clone) of each homologous strain. the five monoclonal antibodies against c. renale 115 p+ pili were divided into 2 groups, comprising 16/5, 160/1 and 32/6 and 13/4 an ... | 1987 | 2433832 |
| keratinolytic activity of cutaneous and oral bacteria. | a test was developed to measure the keratinolytic activity of cutaneous and oral bacteria. keratin, labeled with fluorescein isothiocyanate, was used in a phosphate buffer (ph 7.2) with 1 mm dithiothreitol. the degradation of keratin was estimated by measuring the fluorescence of the degradation products in the supernatant of the reaction mixtures in a luminescence spectrometer. several oral and cutaneous bacteria were investigated: bacteroides gingivalis, bacteroides intermedius, treponema dent ... | 1987 | 2434427 |
| mechanism of recovery from acute virus infection. iv. questionable role of mononuclear phagocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice. | after intravenous infection of mice with 10(3) infectious units (iu) the we strain lymphocytic choriomeningitis (lcm) virus multiplied in the spleens (as in all other major organs), reaching more than 10(8) iu/g of tissue on days 4 to 5. subsequently, the virus was quickly eliminated, being below detectability usually by day 10. during the time of virus clearance, the mononuclear phagocytes (mnp) of the spleen were activated as revealed by suppression of growth of listeria monocytogenes and incr ... | 1987 | 2435795 |
| symptomatic treatment of recurrent malignant pleural effusions with intrapleurally administered corynebacterium parvum. clinical response is not associated with evidence of enhancement of local cellular-mediated immunity. | intrapleural injection of corynebacterium parvum (cbp) has been recently proposed as a useful symptomatic treatment of recurrent malignant effusions. although the result is often a fibrotic thickening of the pleura, cbp is thought to stimulate the effector cells present in the effusion and, possibly, to activate the antitumor cytotoxic activity of the pleural fluid mononuclear cells. to test this hypothesis, we studied 7 patients with recurrent malignant pleural effusions caused by lung cancer a ... | 1987 | 2436513 |
| role of interferon, antibodies and macrophages in the protective effect of corynebacterium parvum on encephalomyocarditis virus-induced disease in mice. | treatment of mice with corynebacterium parvum enhances their resistance to encephalomyocarditis (emc) virus infection. in emc-virus-infected mice, pretreated with c. parvum, neither interferon production nor antibody responses were increased. a decrease of virus recovery was observed in cultures of macrophages taken from the peritoneum of mice early after injection of c. parvum and infected with emc-virus in vitro. the data suggest that c. parvum acts by increasing intrinsic antiviral activity o ... | 1987 | 2440381 |
| kinetic studies on the reaction mechanism of sarcosine oxidase. | a sarcosine oxidase (sarcosine: oxygen oxidoreductase (demethylating), ec 1.5.3.1) isolated from corynebacterium sp. u-96 contains both covalently bound fad and noncovalently bound fad. the noncovalent fad reacts with sarcosine, the covalent fad with molecular oxygen (jorns, m.s. (1985) biochemistry 24, 3189-3194). to clarify the reaction mechanism of the enzyme, kinetic investigations were performed by the stopped-flow method as well as by analysis of the overall reaction. the absorption spectr ... | 1987 | 2443179 |
| the detection of obligate anaerobic bacteria in udder secretions of dry cattle with mastitis during summer: a comparison between gas-liquid chromatography and bacteriological culturing methods. | udder secretions sampled during the summer in 1984 and 1985 from mastitic quarters of 51 non-lactating cattle, mainly heifers less than 2 years of age, were examined bacteriologically for the presence of (facultative) aerobic and obligate anaerobic bacteria (oab) and by gas-liquid chromatography (glc) in order to detect volatile fatty acids (vfa), metabolic end-products of oab. forty-nine samples yielded positive cultures and in 20 cases these were mixtures of (facultative) aerobes and oab. only ... | 1987 | 2444028 |
| [isolation and immunochemical characteristics of soluble membrane proteins from the cell wall of corynebacterium diphtheria]. | a method for isolation of immunochemically active proteins from corynebacterium diphtheria membranes was elaborated. the proteins were solubilized with the nonionic detergent np-40 and gel-filtered through an ultrogel aca-34 column under denaturating conditions. the purified proteins (mr = 64 kd) were antigenically active in a solid phase radioimmunoassay with human antidiphtheria antibodies. | 1987 | 2444270 |
| endogenous production of tumor necrosis factor in normal mice and human cancer patients by interferons and other cytokines combined with biological response modifiers of bacterial origin. | the priming effect of endogenous biological response modifiers (brms), interferons (ifns), and interleukin-2 (il2), and the triggering effect of brms of bacterial origin, ok-432 and corynebacterium parvum, on endogenous production of the tumor necrosis factor (tnf) were investigated in mice. tnf activity in serum was measured by in vitro cytotoxicity assay with l-929 cells as a target. the i.v. injection of ok-432 (3ke per mouse) triggered tnf maximally (mean value: 30 u/ml) after 2 h, with a si ... | 1987 | 2445926 |
| [use of immunoenzyme analysis for determining antibacterial antibodies in diphtheria infection]. | a diagnostic eia system for the detection of antibacterial antibodies in diphtheria infection has been developed. as antigen, homogeneous membrane protein (mol. wt. 64 kd) obtained from corynebacterium diphtheriae cell walls has been used. this protein antigen has been prepared with the use of nonionic detergent np-40. | 1987 | 2446452 |
| effect of immunostimulants and antitumor agents on tumor necrosis factor (tnf) production. | ok-432, a lyophilized preparation of streptococcus pyogenes, showed a priming activity for tnf production in mice, associated with an increase of spleen weight. psk, a protein-bound polysaccharide preparation from coriolus versicolor, did not show such activity. both ok-432 and psk potentiated the tnf production in mice primed with corynebacterium parvum (cp) and challenged with escherichia coli endotoxin (lps). cytotoxic antitumor agents of 5-fluorouracil (5-fu), cyclophosphamide (cy) and bleom ... | 1987 | 2448255 |
| modulation of major histocompatibility complex (mhc) expression by interferons and microbial agents. independent regulation of mhc class ii expression and induction of tumoricidal activity in bone marrow-derived mononuclear phagocytes. | in a pure population of rat bone marrow-derived mononuclear phagocytes (bmm phi), the expression of major histocompatibility complex (mhc) molecules and ability to manifest tumoricidal activity were simultaneously studied. resting bmm phi, which express low levels of mhc class ii molecules and do not manifest tumoricidal activity, become strongly mhc class ii-positive, and evolve tumoricidal activity within 24 h when incubated with macrophage-activating lymphokines (maf) or gamma interferon (ifn ... | 1988 | 2456605 |
| molecular-genetic evidence for the relationship of mycobacterium leprae to slow-growing pathogenic mycobacteria. | a total of 1170 nucleotides of the 16s rrna from mycobacterium leprae were compared to the homologous regions of m. tuberculosis, m. bovis vallée, m. avium, m. scrofulaceum, m. phlei, m. fortuitum and one representative each of the genera corynebacterium, nocardia, and rhodococcus. homology values were calculated and a phylogenetic tree was constructed from the evolutionary distance values. despite differences in dna g + c content and genome size, m. leprae is a true member of the slow-growing p ... | 1988 | 2458422 |
| association of bovine respiratory syncytial virus with atypical interstitial pneumonia in feedlot cattle. | thirty-three cattle with fatal respiratory tract disease were examined for gross and histologic lesions and for the presence of viral and bacterial agents in the lungs. fifteen cattle had lesions characteristic of atypical interstitial pneumonia (aip), and 18 had other respiratory tract diseases, including infectious bovine rhinotracheitis, shipping fever pneumonia, bronchopneumonia, pulmonary abscess, and edema of the trachea. gross necropsy findings in the cattle with aip were uncollapsed and ... | 1988 | 2458690 |
| deficiency in interferon production of peripheral blood leukocytes from patients with non-hodgkin lymphoma. | in search for a rationale for the use of interferons (ifns) in treatment of non-hodgkin lymphoma (nhl), we have investigated the ifn system of 13 patients with low-grade nhl, 15 patients with high-grade nhl, and 20 patients with chronic lymphocytic leukemia or leukemic immunocytoma (cll/ic). production of ifn induced by phytohemagglutinin (pha), concanavalin a (con a), pokeweed mitogen (pwm), corynebacterium parvum, herpes simplex virus (hsv), newcastle disease virus (ndv), and interleukin 2 (il ... | 1988 | 2459268 |
| the use of non-specific immunopotentiators in experimental trypanosoma cruzi infection. | the effects of levamisole, isoprinosine and corynebacterium parvum on trypanosoma cruzi (y strain) experimental infection of mice were studied. in prophylactic treatment these drugs reduced the peak of parasitaemia, and had no apparent effect on mortality rate or on histopathological and electrocardiographic findings. levamisole and isoprinosine had no effect when used after infection. electrocardiograms were obtained from all chronic chagasic mice. the most frequent changes were left atrial ove ... | 1988 | 2459820 |
| a randomized trial of intracavitary bleomycin and corynebacterium parvum in the control of malignant pleural effusions. | fifty-eight patients with malignant pleural effusions were entered into a prospectively randomized clinical trial comparing the efficacy of a local instillation of bleomycin or corynebacterium parvum (c. parvum) in controlling fluid reaccumulation after simple needle aspiration (thoracentesis). the response was assessed at 30 days by chest x-ray and clinical examination. there were 44 evaluable patients; 18 of 25 (72%) of those receiving bleomycin and 9/19 (47%) of those who had c. parvum gained ... | 1989 | 2467327 |
| [a method of reversed radial immunodiffusion and determination of diphtheria antibodies]. | measurements of precipitating antidiphtheria antitoxic and antibacterial antibodies in human blood sera, carried out by this new technique, have demonstrated higher levels of both antibody types in healthy adult vaccinees than in normal subjects who had contacts with diphtheria patients. convalescents after diphtheria develop elevated levels of antitoxic and antibacterial antibodies, these levels growing to reach the concentrations similar to those in healthy vaccinees. | 1989 | 2470970 |
| [a new modification of pizu's medium for the rapid identification of corynebacterium diphtheriae based on the agv medium]. | various nutrient bases (dry nutrient agar, erythrol agar, medium for toxigenicity determination, casein-yeast and agv media) have been examined to choose a base for pizu's medium instead of agar d that is no longer manufactured. agv medium has been found the best nutrient base. the method for the preparation of pizu's medium has been simplified. the modified pizu's medium permits the detection of cystinase in c: diphtheriae in 3-5 hrs both in pure and mixed cultures. | 1989 | 2470979 |
| diphtheria among alcoholic urban adults. a decade of experience in seattle. | three outbreaks of corynebacterium diphtheriae infection occurred in seattle's skid road from 1972 through 1982. the first involved a single toxigenic, intermedius biotype clone, whereas the second and third outbreaks involved nontoxigenic mitis and gravis strains. of 1100 total infections, 947 (86%) were cutaneous. the incidence was highest in winter and spring. in skid road, the estimated attack rate during 17 months in 1974 to 1975 was 5% for whites and 27% for native americans. streptococcus ... | 1989 | 2472081 |
| expression of a poliovirus type 1 neutralization epitope on a diphtheria toxin fusion protein. | the diphtheria toxin (dt) secreted by corynebacterium diphtheriae is used after formolization as an efficient vaccine against diphtheria. in an attempt to evaluate its capacity to present heterologous peptide sequence in a recognized form, we created in-phase insertion in the gene encoding the non-toxic mutant protein crm228 of dt. the sequence chosen for insertion was the synthetic dna fragment encoding a poliovirus neutralization epitope. tripartite fusion proteins comprising the mutant dt, th ... | 1989 | 2473577 |
| comparison of corynebacterium parvum and bordetella pertussis with freund's complete adjuvant as immunopotentiators for beta-human chorionic gonadotropin linked to an atoxic fragment of tetanus toxin. | corynebacterium parvum and bordetella pertussis were compared with freund's complete adjuvant (fca) for their abilities to potentiate the immune response to haptenic beta-human chorionic gonadotropin covalently coupled to an atoxic 54,000-molecular-weight fragment of tetanus toxin (beta-hcg-ttii). the ability of each adjuvant to enhance production of antibodies to hcg in rabbits was measured by 125i-hcg radioimmunoassay. at sera dilutions of 1:10,000, analysis of variance for the 8-week postimmu ... | 1989 | 2475138 |
| bacterial sarcosine oxidase: identification of novel substrates and a biradical reaction intermediate. | corynebacterial sarcosine oxidase contains both covalently and noncovalently bound fad and forms complexes with various heterocyclic carboxylic acids (d-proline and 2-furoic, 2-pyrrolecarboxylic, and 2-thiophenecarboxylic acids). 2-furoic acid, a competitive inhibitor with respect to sarcosine, selectively perturbs the absorption spectrum of the noncovalent flavin, suggesting that the enzyme has a single sarcosine binding site near the noncovalent flavin. several heterocyclic amines have been id ... | 1989 | 2475174 |
| analysis of propionibacterium acnes-induced non-specific immunity to trypanosoma brucei in mice. | mice treated with dead propionibacterium acnes (previously called corynebacterium parvum), up to 30 days before infection with any of three strains of trypanosoma brucei, were more able to limit the level of first-wave parasitaemia than untreated controls. reduced parasitaemia was not due to enhanced phagocytosis of input parasites and was associated with a dramatic reduction in the proportion of multiplying t. brucei in the blood of treated as compared to control mice. for 4 days after p. acnes ... | 1989 | 2476711 |
| [a comparative study of nutrient media for isolating corynebacterium diphtheriae]. | the diagnostic characteristics of 8 nutrient media most frequently employed at practical bacteriologic laboratories for the isolation of c. diphtheriae have been under study. clauberg-2 medium and blood-tellurite agar have been found the most suitable for the diagnostic studies. addition of extra ingredients to the standard recipe deteriorates the diagnostic potentialities of the media. tinsdal's medium is characterized by the lowest diagnostic efficacy. the schemes of using these media are pres ... | 1989 | 2477635 |
| effect of location on severity and prognosis of limb cellulitis in six cows. | six dairy cows with limb cellulitis responded differently to treatment. the location of the cellulitis on the limb seemed to influence the course, severity and prognosis of the disease, as judged by its responsiveness to therapy. cellulitis which extended from the coronet to above the carpus or hock was more severe and had a poorer prognosis than cellulitis distal to these joints. the degree of lameness exhibited by the cows indicated the severity and extent of the underlying cellulitis. | 1989 | 2477939 |
| germ monitoring of patients, staff and environment in reverse isolation. | to estimate the efficiency of germ-poor for patients who underwent bmt or abmt in reverse isolation we investigated the staff, patients and the environment of the bmt unit bacteriologically and mycologically between 1/85 to 3/87. on patient's body surface gram-negative germs were not estimated but coagulase negative staphylococci persisted. only in few cases aerobic spores were detectable, seldom enterococci, corynebacterium and fungi. staff members had a distinct higher grade of contamination i ... | 1989 | 2480311 |
| characterization of interferons produced by peripheral blood mononuclear cells from healthy subjects in response to corynebacterium parvum or poly i: poly c. | the biological significance of acid labile interferon alpha is presently unknown. we examined the putative production of acid labile interferon in vitro from human peripheral blood mononuclear cells induced with corynebacterium parvum or poly i: poly c. both agents induced up to 1200 iu/ml interferon, and the interferon was 80 to 90% acid labile. the interferons were typed by antibody neutralization of their antiviral activity. contrary to previous reports, c. parvum induced predominantly interf ... | 1989 | 2483976 |
| induction of macrophage tumoricidal activity, major histocompatibility complex class ii antigen (iak) expression, and interleukin-1 production by swainsonine. | previous studies in our laboratory have shown that the reported antitumor activity of systemically administered swainsonine, an indolizidine alkaloid, is due at least in part to immune modulation involving effector cells (humphries, m.j.; matsumoto, k; white, s.l.; olden, k. cancer res. 48:1410-1415; 1988 and white, s. l.; schweitzer, k.; humphries, m.j.; olden, k. biochem. biophys. res. commun. 150:615-625; 1988). in this report, studies are presented to show that swainsonine was effective in a ... | 1989 | 2484638 |
| the anophthalmic socket and the prosthetic eye. a clinical and bacteriologic study. | culture samples were obtained from the anophthalmic sockets of 40 consecutive patients using a prosthetic eye. we found an increased prevalence of bacteria in the conjunctivae of anophthalmic sockets. no significant differences in bacterial flora were observed between symptomatic and asymptomatic patients, suggesting that symptoms of irritation are not usually related to abnormal bacterial flora. patients who frequently manipulated their prosthesis had a significantly higher proportion of gram-n ... | 1989 | 2487236 |
| modulation of macrophage functions by corynebacterium parvum preparations. | corynebacterium parvum has been used as an anti-tumor agent in both animal experiments and clinical trials; nevertheless it is not well established the mechanism of action, since both t-dependent and t-independent ways of action have been proposed. on the other hand, mononuclear phagocytic system activation cannot be ruled out in the immunomodulation carried out by c. parvum. in the attempt to better understand the effects of c. parvum on macrophage functions, experiments were carried out on tum ... | 1989 | 2491287 |
| [corynebacterium d2-induced encrusted cystitis]. | two cases of patients with cystitis cystica secondary to urine infection, caused by resistant corynebacterium d2, are presented. the clinical features were important dysuria and frequency, alkaline urine ph (ph 8 and 9). the urine cultures were obtained with the standard techniques, after 72 hours of incubation. they were treated with vancomycin, ciprofloxacin and hydroxinamic acid with good response. | 1989 | 2491476 |
| purification and characterisation of an inducible beta-galactosidase from corynebacterium murisepticum. | the beta-galactosidase (ec 3.2.1.32) of corynebacterium murisepticum (inducible by lactose and galactose) was purified by successive column chromatography on sephadex g-200, deae-sephadex a-50 and deae-cellulose (de52). the enzyme was found to be a dimer of identical subunits of molecular mass 100,000 daltons. the km values of the enzyme for the substrates lactose and o-nitrophenyl-beta-d-galactopyranoside (onpg) are 16.7 mm and 4.4 mm, respectively, indicating, its low affinity for the substrat ... | 1989 | 2492796 |
| epithelial dendritic cells and connective tissue macrophages in oral carcinogenesis and the effects of systemic corynebacterium parvum. | epithelial dendritic cells (edc) and connective tissue macrophages were examined during the induction and growth of oral squamous cell carcinomas in sprague-dawley rats treated with the carcinogen 4-nitroquinoline n-oxide (4nqo) and the immune potentiator corynebacterium parvum. splenomegaly was induced in all animals receiving c. parvum. acetone-fixed frozen sections of the palate and tongue were stained using an indirect immunoperoxidase technique and monoclonal antibodies to rat ia (mrc ox-6) ... | 1989 | 2493998 |
| the molecular epidemiology of three biotypes of corynebacterium diphtheriae in the seattle outbreak, 1972-1982. | between 1972 and 1982 seattle experienced a diphtheria outbreak involving 1,100 cases, primarily adults with cutaneous lesions. biotyping revealed three consecutive overlapping outbreaks including 433 toxinogenic intermedius cases. isolates from each quarter year were examined for dna restriction fragment patterns and hybridization patterns with three dna probes. all intermedius outbreak isolates appeared identical in all analyses and most stock cultures had the outbreak dna fragment pattern, bu ... | 1989 | 2494266 |
| influence of increased aspartate availability on lysine formation by a recombinant strain of corynebacterium glutamicum and utilization of fumarate. | aspartate availability was increased in corynebacterium glutamicum strains to assess its influence on lysine production. upon addition of fumarate to a strain with a feedback-resistant aspartate kinase, the lysine yield increased from 20 to 30 mm. this increase was accompanied by the excretion of malate and succinate. in this strain, fumaric acid was converted to aspartate by fumarate hydratase, malate dehydrogenase, and aspartate amino transferase activity. to achieve the direct conversion of f ... | 1989 | 2494939 |
| in-vitro activity of lomefloxacin in comparison with pefloxacin and ofloxacin. | the in-vitro activity of lomefloxacin (sc 47111, ny-198) was investigated by the determination of mics in agar and in broth, of mbcs in broth, of killing curves and of the duration of the post-antibiotic effect. mics measured in broth and in agar were almost identical. lomefloxacin was two- to eight-fold less active against gram-positive bacteria than ofloxacin. its activity against staphylococcus aureus was independent of resistance to penicillin and oxacillin. the activity of lomefloxacin, ofl ... | 1989 | 2496071 |
| the aldo-keto reductase superfamily. cdnas and deduced amino acid sequences of human aldehyde and aldose reductases. | aldehyde reductase [ec 1.1.1.2] and aldose reductase [ec 1.1.1.21] are monomeric nadph-dependent oxidoreductases having wide substrate specificities for carbonyl compounds. these enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. enzyme inhibition as a direct pharmacokinetic approach to the prevention of diabetic complications resulting from the hyperglycemia of diabetes has not been effective because of nonspecificity of the i ... | 1989 | 2498333 |
| in-vitro activity of the streptogramin group of antimicrobials against corynebacterium jeikeium and d2 coryneform bacteria. | | 1989 | 2499566 |
| [infections which humans in the household transmit to dogs and cats]. | an overview of the most important infections which can be transmitted from humans to pet dogs and cats is presented. two quite different sources of infection stand diametrically opposite each other: 1. the transmission of active human infections to dogs and cats and 2. the transmission of infectious agents by feeding raw meat, offal, unsterilized milk products, kitchen scraps and contaminated feedstuffs. humans can be the source of the following infections: 1. zoonoses with reciprocal modes of t ... | 1989 | 2500809 |
| [evaluation of the efficiency of a new dried nutrient medium for isolating corynebacterium diphtheriae]. | tellurite blood media prepared on a new dried base with amino peptide have been found to have advantages, when used for the bacteriological diagnosis of c. diphtheriae infection, over buchin's selective quinosol medium with respect to the rate and time of the isolation of c. diphtheriae; besides, these new media have been found to possess pronounced differentiating properties with respect to the concomitant microflora. | 1989 | 2500817 |
| [the coagglutination reaction for detecting diphtheria toxin]. | high-titer antidiphtheria antitoxic rabbit serum has been obtained, and on the basis of this serum a coagglutinating diagnosticum has been developed. the sensitivity of the test has been found to depend on the content of antitoxic antibodies in the serum and on its purity. diagnostica prepared from native serum containing 500 i. u./ml (a titer of 1:51, 200 in the passive hemagglutination test) permit the detection of 0.02-0.03 lf/ml of diphtheria toxin. a decrease in antibody titer to 5-25 i. u. ... | 1989 | 2500820 |
| [role of normal microflora in the throat in inhibition of adherence of pathogenic bacteria to host cells: in vitro competitive adherence between corynebacterium pseudodiphtheriticum and branhamella catarrhalis]. | our previous study showed the occurrence of branhamella catarrhalis (b. catarrhalis) pulmonary infections which varies seasonally. to investigate the role of normal throat microflora in this seasonal variation of the occurrence of b. catarrhalis infection, seventy seven throat cultures were done in 45 patients with chronic pulmonary diseases from january to december in 1985. the isolation rate of corynebacterium species as normal microflora was relatively higher in summer than in winter. therefo ... | 1989 | 2501428 |
| effect of intracerebrally injected corynebacterium parvum on implanted brain tumor in mice. | experiments were performed to determine the effectiveness of corynebacterium parvum on resistance to growth and development of tumor in the central nervous system. a syngeneic sarcoma was injected intracerebrally into c3h/hen/mtv-negative female mice that had received intraperitoneal injections of c. parvum or saline prior to tumor inoculation or that received intraperitoneal c. parvum or saline after tumor inoculation. groups then received an intracerebral injection of c. parvum or saline. our ... | 1989 | 2502606 |
| different sensitivity of pseudomonas aeruginosa exotoxin a and diphtheria toxin to enzymes from polymorphonuclear leukocytes. | we demonstrate that exotoxin a (exoa) of pseudomonas aeruginosa is one to two orders of magnitude more sensitive than diphtheria toxin (dt) of corynebacterium diphtheriae to lysosomal enzymes from polymorphonuclear leukocytes (pmn). it is especially sensitive to pmn elastase which inactivates its cell free enzymatic activity and its cytotoxicity as measured with the chinese hamster ovary cell assay and the rabbit skin test. sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page) sh ... | 1989 | 2502701 |
| [the most frequent infectious causes of abortion in sheep in north bavaria with special reference to chlamydia and salmonella infections]. | between 1980 and 1987 1153 ovine fetuses and placentas were examined after abortion. in 68.5% of the cases a cause of abortion could be diagnosed as follows: 43.5% chlamydia psittaci var. ovis, 10.7% salmonella abortus ovis, 3.7% coxiella burnetii, 3.3% listeria monocytogenes and 0.4% campylobacter fetus intestinalis. hemolyzing escherichia coli and streptococci, yersinia pseudotuberculosis, salmonella typhimurium, salmonella enteritidis, corynebacterium pyogenes and other facultative pathogens ... | 1989 | 2503908 |