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[a case of liver abscess due to streptococcus anginosus infection secondary to a dental extraction].a 74-year-old man was referred to our hospital because of a high fever. he had undergone a dental extraction about 1 month prior to admission because of apical periodontitis. imaging study revealed liver abscess lesions. infection with streptococcus anginosus was confirmed using both stab and blood culture. an adequate selection of antibiotics was administered, and a good outcome was obtained. there have been no case reports of liver abscess caused by intraoral commensal flora related to dental ...201526250133
simultaneous bilateral decortications via video-assisted thoracic surgery for bilateral empyema.bilateral empyema is a rare and life-threatening condition that is difficult to treat. we herein report a case of bilateral empyema that was treated with simultaneous bilateral decortications via video-assisted thoracic surgery (vats).201525528031
subperiosteal abscess of the orbit: evolving pathogens and the therapeutic protocol.because of widespread antibiotic use, immunization against selective species, and the emergence of hypervirulent organisms, we sought to determine changes over time in the bacteriology of sinusitis-related subperiosteal abscess (spa) of the orbit and their impact on patient outcomes under a uniform management protocol.201525439602
streptolysin s of streptococcus anginosus exhibits broad-range hemolytic activity.streptococcus anginosus is a commensal of mucous membranes and an emerging human pathogen. some strains, including the type strain, display a prominent β-hemolytic phenotype. a gene cluster (sag), encoding a variant of streptolysin s (sls) has recently been identified as the genetic background for β-hemolysin production in s. anginosus. in this study, we further characterized the hemolytic and cytolytic activity of the s. anginosus hemolysin in comparison with other streptococcal hemolysins. the ...201525381594
incorporation of staphylococci into titanium-grown biofilms: an in vitro "submucosal" biofilm model for peri-implantitis.staphylococcus spp. are postulated to play a role in peri-implantitis. this study aimed to develop a "submucosal" in vitro biofilm model, by integrating two staphylococci into its composition.201526461083
quantitative proteomics reveal distinct protein regulations caused by aggregatibacter actinomycetemcomitans within subgingival biofilms.periodontitis is an infectious disease that causes the inflammatory destruction of the tooth-supporting (periodontal) tissues, caused by polymicrobial biofilm communities growing on the tooth surface. aggressive periodontitis is strongly associated with the presence of aggregatibacter actinomycetemcomitans in the subgingival biofilms. nevertheless, whether and how a. actinomycetemcomitans orchestrates molecular changes within the biofilm is unclear. the aim of this work was to decipher the inter ...201525756960
antimicrobial, antitumor and brine shrimp lethality assay of ranunculus arvensis l. extracts.to investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of methanol extract (me), water extract (we), acetone extract (ae), chloroform extract (ce), methanol-water extract (mwe), methanol-acetone extract (mae), methanol-chloroform extract (mce) of ranunculus arvensis (l.). antitumor activity was evaluated with agrobacterium tumefaciens (at10) induced potato disc assay. cytotoxicity was evaluated with brine shrimp lethality assay. antibacterial a ...201526004705
quantification of pseudomonas aeruginosa in multispecies biofilms using pma-qpcr.multispecies biofilms are an important healthcare problem and may lead to persistent infections. these infections are difficult to treat, as cells in a biofilm are highly resistant to antimicrobial agents. while increasingly being recognized as important, the properties of multispecies biofilms remain poorly studied. in order to do so, the quantification of the individual species is needed. the current cultivation-based approaches can lead to an underestimation of the actual cell number and are ...201525755923
establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system.periodontal infection involves a complex interplay between oral biofilms, gingival tissues and cells of the immune system in a dynamic microenvironment. a humanized in vitro model that reduces the need for experimental animal models, while recapitulating key biological events in a periodontal pocket, would constitute a technical advancement in the study of periodontal disease. the aim of this study was to use a dynamic perfusion bioreactor in order to develop a gingival epithelial-fibroblast-mon ...201525587671
surrogate analysis of vancomycin to predict susceptible categorization of dalbavancin.dalbavancin (dal) represents a recently approved addition for the treatment of acute bacterial skin and skin structure infections (absssis). newly released antimicrobial agents are rarely found on commercial susceptibility testing devices, and surrogate testing may be an option for clinical microbiology laboratories. a total of 33,688 staphylococcus aureus, 2800 viridans group streptococci (vgs), and 5722 β-hemolytic streptococci (bhs) were included in this cross-susceptibility (dal versus vanco ...201525724854
polymicrobial purulent pericarditis probably caused by a broncho-lymph node-pericardial fistula in a patient with tuberculous lymphadenitis.purulent pericarditis is a rare condition with a high mortality rate. we report a case of purulent pericarditis subsequently caused by candida parapsilosis, peptostreptococcus asaccharolyticus, streptococcus anginosus, staphylococcus aureus, prevotella oralis, and mycobacterium tuberculosis in a previously healthy 17-year-old boy with mediastinal tuberculous lymphadenitis. the probable route of infection was a bronchomediastinal lymph node-pericardial fistula. the patient improved with antibioti ...201526788411
[isolation and identification of aerobic and facultative anaerobic bacteria in the oral cavity].to establish a systematic method for isolation and identification of aerobic and facultative anaerobic bacteria in the oral cavity.201526714902
a reference broth microdilution method for dalbavancin in vitro susceptibility testing of bacteria that grow aerobically.antimicrobial susceptibility testing (ast) is performed to assess the in vitro activity of antimicrobial agents against various bacteria. the ast results, which are expressed as minimum inhibitory concentrations (mics) are used in research for antimicrobial development and monitoring of resistance development and in the clinical setting for antimicrobial therapy guidance. dalbavancin is a semi-synthetic lipoglycopeptide antimicrobial agent that was approved in may 2014 by the food and drug admin ...201526381422
telavancin: mechanisms of action, in vitro activity, and mechanisms of resistance.telavancin is a semisynthetic lipoglycopeptide derivative of vancomycin. telavancin has a dual mechanism of antibacterial action, disrupting peptidoglycan synthesis and cell membrane function. in 2014, the clinical and laboratory standards institute (clsi) revised the antimicrobial susceptibility testing method for telavancin, resulting in minimum inhibitory concentration (mic) determinations that are more accurate and reproducible and demonstrate greater in vitro potency than shown with the pre ...201526316559
in vitro activities of tedizolid and linezolid against gram-positive cocci associated with acute bacterial skin and skin structure infections and pneumonia.tedizolid is a novel, expanded-spectrum oxazolidinone with potent activity against a wide range of gram-positive pathogens. a total of 425 isolates of gram-positive bacteria were obtained consecutively from patients with acute bacterial skin and skin structure infections (absssis) or pneumonia. these isolates included methicillin-susceptible staphylococcus aureus (mssa) (n = 100), methicillin-resistant staphylococcus aureus (mrsa) (n = 100), streptococcus pyogenes (n = 50), streptococcus agalact ...201526248355
activity of oritavancin against gram-positive clinical isolates responsible for documented skin and soft-tissue infections in european and us hospitals (2010-13).to assess oritavancin activity in vitro against clinically relevant gram-positive pathogens causing skin and soft-tissue infections (sstis) in european and us hospitals.201525362568
solitary pyomyositis of the left rhomboideus muscle caused by streptococcus anginosus and streptococcus intermedius in an immunocompetent person.primary pyomyositis is a bacterial infection of the skeletal muscle commonly affecting children with staphylococcus aureus most often isolated as a pathogen. however, pyomyositis caused by anaerobic bacteria is rare in adults. here, we report a case of solitary pyomyositis of the left rhomboideus muscle in an immunocompetent person. a 70-year-old japanese male presented with high fever and left shoulder pain. his muscle below the lower edge of the left scapula was tender and swollen. his laborat ...201526185692
[management of nasal orbital cellulitis in children].to analyze the clinical characteristics, diagnostic and treatment principle of orbital cellulitis in children, and to improve the experience of antibiotic treatment in orbital cellulites.201525764921
complete genome sequence of streptococcus anginosus j4211, a clinical isolate.streptococcus anginosus is an opportunistic human pathogen that causes abscesses of the brain, liver, and other organs. here, we announce the complete genome sequence of a clinically isolated strain of s. anginosus j4211. the genome sequence contains two prophages and multiple mobile genetic elements.201526679576
the clinical features of respiratory infections caused by the streptococcus anginosus group.the streptococcus anginosus group (sag) play important roles in respiratory infections. it is ordinarily difficult to distinguish them from contaminations as the causative pathogens of respiratory infections because they are often cultured in respiratory specimens. therefore, it is important to understand the clinical characteristics and laboratory findings of respiratory infections caused by the sag members. the aim of this study is to clarify the role of the sag bacteria in respiratory infecti ...201526502716
spontaneous septic arthritis of the pubic symphysis in an afebrile patient.septic arthritis is a rare infection usually involving the knee or hip but can infrequently affect less obvious joints such as the pubic symphysis.risk factors for septic arthritis include joint repair or replacement surgery, systemic infection, intravenous recreational drug use, and alcoholism.we present the case of a 48-year-old man with a final diagnosis of septic arthritis of the pubic symphysis who had no risk factors besides alcoholism. the presentation was unusual in that the patient was ...201626475359
microbial causes of complicated acute bacterial rhinosinusitis and implications for empirical antimicrobial therapy.very little up-to-date information is available on the microbiology of complicated acute bacterial rhinosinusitis. reliable microbiology testing is necessary to inform current empirical antimicrobial treatments. this study was conducted in response to recent us guidelines on antimicrobial treatments for acute bacterial rhinosinusitis. it aimed to describe the pathological micro-organisms involved in complicated acute bacterial rhinosinusitis in the uk and their antimicrobial susceptibility.201626678822
the streptococcus milleri group in chronic obstructive pulmonary disease.s. anginosus, constellatus and intermedius, also known as the streptococcus milleri group (smg) are three streptococcal species more frequently detected in cases of invasive disease, abscesses and empyema in particular. recent research suggests they play a role in exacerbations of cystic fibrosis (cf). owing to poor recovery on standard culture media and difficult differentiation from non-pathogenic streptococci, smg may be underdiagnosed in routine settings. we aimed to establish the incidence ...201627132809
ceftaroline activity tested against viridans group streptococci from us hospitals.a total of 840 clinically relevant viridans group streptococci (vgs) isolates (1/patient episode) were collected from 71 us medical centers in 2013-2014. these organisms were tested for susceptibility by reference broth microdilution methods against ceftaroline and selected comparator agents. all isolates were speciated by matrix-assisted laser desorption ionization-time-of-flight (maldi-tof) mass spectrometry and were primarily from skin/soft tissue (32.6%) and bloodstream (32.3%) infections. c ...201626658313
multiple brain abscesses due to streptococcus anginosus: prediction of mortality by an imaging severity index score.an elderly patient with altered mental status, brain abscesses, ventriculitis, and empyemas died of septic shock and brain abscesses secondary to streptococcus anginosus despite aggressive treatment. an imaging severity index score with a better prognostic value than the glasgow coma scale predicted mortality in this patient.201627034878
pyogenic ventriculitis as clinical presentation of diverticulitis. 201626928780
infection necrosis after an extracorporeal reduction of a condyle fracture.the authors experienced a patient of infection necrosis after an extracorporeal reduction of a condyle fracture and reconstructed it with an iliac bone graft.a 37-year-old man visited with a bilateral condyle fracture and a left para-symphyseal fracture. on the post-trauma third day, an intermaxillary fixation was applied using arch bars. on the post-trauma tenth day, an extracorporeal reduction was carried out. on postoperative day (pod) 7, the amount of the drain was 9 cc and the drain was rem ...201627054427
assessing the use of quantitative light-induced fluorescence-digital as a clinical plaque assessment.the aims of this study were to compare the relationship between red fluorescent plaque (rf plaque) area by quantitative light-induced fluorescence-digital (qlf-d) and disclosed plaque area by two-tone disclosure, and to assess the bacterial composition of the rf plaque by real time-pcr.201626691322
activities of tedizolid and linezolid determined by the reference broth microdilution method against 3,032 gram-positive bacterial isolates collected in asia-pacific, eastern europe, and latin american countries in 2014.tedizolid and linezolid in vitro activities against 3,032 gram-positive pathogens collected in asia-pacific, eastern european, and latin american medical centers during 2014 were assessed. the isolates were tested for susceptibility by the current reference broth microdilution methods. due to concern over the effect of mic endpoint criteria on the results of testing the oxazolidinones tedizolid and linezolid, mic endpoint values were read by two methods: (i) reading the mic at the first well whe ...201627353270
pediatric nasal orbital cellulitis in shenzhen (south china): etiology, management, and outcomes.the study aimed to investigate the clinical characteristics, diagnosis, and treatment of orbital cellulitis in children in shenzhen, china, and to improve the experience of antibiotic therapy for the treatment of orbital cellulites.201627368452
microbiology and choice of antimicrobial therapy for acute sinusitis complicated by subperiosteal abscess in children.review past studies of the microbiology of subperiosteal abscesses (spoa) complicating sinusitis in children and their implications of the antimicrobials administered to treat the infection.201627063747
impressive performance: new disposable digital ureteroscope allows for extreme lower pole access and use of 365 μm holmium laser fiber.since the development of the first flexible ureteroscope, in 1964, technological advances in image quality, flexibility, and deflection have led to the development of the first single-use digital flexible ureteroscope, lithovue™ (boston scientific, marlborough, ma). with respect to reusable fiber-optic and now digital ureteroscopes, there is an initial capital cost of several thousand dollars (usd) as well as, controversy regarding durability, the cost of repairs and the burdensome reprocessing ...201627579436
effect of smokeless tobacco products on human oral bacteria growth and viability.to evaluate the toxicity of smokeless tobacco products (stps) on oral bacteria, seven smokeless tobacco aqueous extracts (staes) from major brands of stps and three tobacco-specific n-nitrosamines (tsnas) were used in a growth and viability test against 38 oral bacterial species or subspecies. all seven staes showed concentration-dependent effects on the growth and viability of tested oral bacteria under anaerobic culture conditions, although there were strain-to-strain variations. in the presen ...201627756619
microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model.the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ...201626033167
cytokine and microbial profiles in relation to the clinical outcome following treatment of peri-implantitis.to study whether cytokine levels and bacterial counts in p atients with peri-implantitis reflect clinical treatment outcome following non-surgical management.201627422156
microbial diversity in the early in vivo-formed dental biofilm.although the mature dental biofilm composition is well studied, there is very little information on the earliest phase of in vivo tooth colonization. progress in dental biofilm collection methodologies and techniques of large-scale microbial identification have made new studies in this field of oral biology feasible. the aim of this study was to characterize the temporal changes and diversity of the cultivable and noncultivable microbes in the early dental biofilm. samples of early dental biofil ...201626746720
[streptococcus anginosus pancreatic abscess after dental extraction]. 201623726739
comparative genome analysis of the daptomycin-resistant streptococcus anginosus strain j4206 associated with breakthrough bacteremia.streptococcus anginosus is a member of the normal oral flora that can become a pathogen causing pyogenic infections in humans. the genome of daptomycin-resistant strain j4206, originally isolated from a patient suffering from breakthrough bacteremia and septic shock at the university of texas health science center at san antonio, was determined. the circular genome is 2,001,352 bp long with a gc content of 38.62% and contains multiple mobile genetic elements, including the phage-like chromosomal ...201627678123
intra-abdominal abscess and primary peritonitis caused by streptococcus anginosus.the streptococcus anginosus group of bacteria are low-virulence bacteria existing as commensals in the oral flora and gastrointestinal tracts of humans. s. anginosus may spread to the blood in individuals with poor oral hygiene in cases of oral infections, such as gingivitis and tooth abscesses, that develop following the loss of mucosal unity. this may lead to infections in the whole body, primarily as brain and liver abscesses.201627630763
the importance of obligate anaerobes and the streptococcus anginosus group in pulmonary abscess: a clone library analysis using bronchoalveolar lavage fluid.appropriate antibiotic use reduces the mortality of patients with lung abscess; however, 40-60% of the bacterial etiologies in these patients have remained unknown with the culture methods. obligate anaerobes and the streptococcus anginosus group are common pathogens in lung abscess, but a precise evaluation of these bacteria by ordinary culture methods seems to be difficult due to upper respiratory tract contamination.201627548533
[atrio-oesophageal fistula after thoracoscopic treatment of atrial fibrillation].an atrio-oesophageal fistula (aof) is a rare but severe complication of radiofrequency ablation during video-assisted thoracoscopic pulmonary vein isolation (vats-pvi).201627438399
[gastrosplenic fistula secondary to gastric adenocarcinoma].we present a case report of a patient with spontaneous gastro-splenic fistula due to gastric adenocarcinoma associated with streptococcus anginosus bacteriemia and fatal outcome.201626228983
case-control study of pneumonia patients with streptococcus anginosus group bacteria in their sputum.in recent years, streptococcus anginosus group (sag) bacteria are becoming increasingly recognized as important pneumonia-causing pathogens. although several small studies have been reported, the features of sag pneumonia remain unclear, because the identification of sag from sputum cultures is not routinely performed in most microbiology laboratories. the aim of this study was to elucidate the clinical characteristics of sag pneumonia.201627681235
machine learning meta-analysis of large metagenomic datasets: tools and biological insights.shotgun metagenomic analysis of the human associated microbiome provides a rich set of microbial features for prediction and biomarker discovery in the context of human diseases and health conditions. however, the use of such high-resolution microbial features presents new challenges, and validated computational tools for learning tasks are lacking. moreover, classification rules have scarcely been validated in independent studies, posing questions about the generality and generalization of dise ...201627400279
molecular characterization and antibiotic resistance of group g streptococci in israel: comparison of invasive, non-invasive and carriage isolates.beta-hemolytic group g streptococci (ggs) are increasingly recognized as a source of substantial morbidity, causing mild to severe sporadic infections as well as outbreaks. the purpose of this study was to determine the genetic diversity and antibiotic resistance of ggs in israel in order to aid in prevention and control. a total of 325 ggs isolates were collected in israel between 2007 and 2011 from three determined settings: (1) carriage (n = 60), an observational longitudinal carriage study i ...201627325440
the sil locus in streptococcus anginosus group: interspecies competition and a hotspot of genetic diversity.the streptococcus invasion locus (sil) was first described in streptococcus pyogenes and streptococcus pneumoniae, where it has been implicated in virulence. the two-component peptide signaling system consists of the sila response regulator and silb histidine kinase along with the silcr signaling peptide and sild/e export/processing proteins. the presence of an associated bacteriocin region suggests this system may play a role in competitive interactions with other microbes. comparative analysis ...201628119678
draft genome sequence of streptococcus anginosus bvi, a new vaginal pathogen candidate.streptococcus anginosus is a pathogen implicated in urogenital and gastroinstestinal tract infections. here, we report the draft genome sequence of s. anginosus bvi, isolated from a bacterial vaginosis patient attending a prenatal care unit in cali, colombia. the genome sequence of bvi consists of 2,014,025 bp, encoding 2,008 predicted proteins.201627979955
cervical necrotizing fasciitis: descriptive, retrospective analysis of 59 cases treated at a single center.to provide retrospective, descriptive information on patients with cervical necrotizing fasciitis treated at a single center during the years 1998-2014, and to evaluate the outcome of a newly introduced treatment strategy. retrospective analysis of clinical data obtained from medical records. mortality, pre-morbidity, severity of illness, primary site of infection, type of bacteria, time parameters. the observed 3-month mortality was 6/59 (10 %). the most common initial foci of the infection wer ...201627287509
streptococcus anginosus (milleri) group strains isolated in poland (1996-2012) and their antibiotic resistance patterns.streptococcus anginosus, streptococcus intermedius and streptococcus constellatus form a group of related streptococcal species, namely the streptococcus anginosus group (sag). the group, previously called "milleri" had been rarely described until 1980/1990 as source of infections. nowadays sag bacteria are often described as pathogens causing predominantly purulent infections. the number of infections is highly underestimated, as sag strains are often classified in the microbiology laboratory a ...201627281992
bloodstream infections caused by streptococcus anginosus group bacteria: a retrospective analysis of 78 cases at a japanese tertiary hospital.to investigate the characteristics of streptococcus anginosus group (sag) bacteremia in recent years, we conducted a retrospective cohort study and compared its findings with the data from previous studies.201627142978
identification of anion channels responsible for fluoride resistance in oral streptococci.recently, it has been reported that eric and crcb are involved in bacterial fluoride resistance. however, the fluoride-resistance mechanism in oral streptococci remains unclear. blast studies showed that two types of erics (eric1 and eric2) and two types of crcbs (crcb1 and crcb2) are present across 18 oral streptococci, which were identified in ≥ 10% of 166 orally healthy subjects with ≥ 0.01% of the mean relative abundance. they were divided into three groups based on the distribution of these ...201627824896
ventricular septal defect and bivalvular endocarditis.a 63-year-old man presented with generalized fatigue, chills, malaise, dyspnea, intermittent fevers, and 50-pound weight loss of 4 months' duration. blood cultures were positive for pan-sensitive streptococcus anginosus. transesophageal echocardiography showed an 11 mm × 3 mm mobile mass attached to the mitral valve, a 16 mm × 16 mm mobile mass attached to the pulmonary valve, and a small membranous ventricular septal defect. the patient received 12 weeks of intravenous (iv) antibiotics with eve ...201725625086
late aortic silver graft re-infection due to streptococcus milleri group (streptococcus anginosus). case report and literature review. 201727883162
colorectal cancer associated with streptococcus anginosus bacteremia and liver abscesses.streptococcus anginosus is part of the normal flora of the human gastrointestinal tract. their ability to cause abscesses is very unique and sets them apart from the rest of the streptococci groups. while an association of group d streptococcus bacteremia and endocarditis with colorectal carcinoma is well established, s. anginosus infections are rarely implicated with colonic malignancy. we present a case of a 62-year-old male who presented to the hospital with fatigue and generalized abdominal ...201728100999
septic arthritis of an atlantoaxial facet joint with normal inflammatory markers: case report and literature review.septic arthritis of the atlantoaxial facet joint is extremely rare. contiguous spread to the median atlantoaxial joints with subsequent dens erosion can lead to atlantoaxial instability. misleading normal inflammatory markers can result in delayed diagnosis and catastrophic consequences.201727993739
characteristics of superior orbital subperiosteal abscesses in children.superior pediatric orbital subperiosteal abscesses (spas) are less common than medial ones, and clinical features specific to patients with superior spas have not been well defined. clinical characteristics between patients with superior and medial spas are compared to determine whether superior location is a risk factor for surgical intervention.201727291943
antibacterial activity of various antibiotics against oral streptococci isolated in the oral cavity.a total of 550 oral streptococci: 270 streptococcus mitis, 110 streptococcus sanguis, 90 streptococcus anginosus, 50 streptococcus mutans, 30 streptococcus salivarius, were isolated from dental plaque and gengival crevices of patients and tested for their susceptibility to 12 β-lactam antibiotics and to 5 non-β-lactam antibiotics, using the microdiluition method. overall, a reduced susceptibility to penicillin was recorded in 13.4% of cases. the percentage of strains resistant to penicillin appe ...201723058035
mucosal microbiome dysbiosis in gastric carcinogenesis.we aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis.201728765474
telavancin: a novel semisynthetic lipoglycopeptide agent to counter the challenge of resistant gram-positive pathogens.telavancin (td-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by theravance for overcoming resistant gram-positive bacterial infections, specifically methicillin-resistant staphylococcus aureus (mrsa). the us food and drug administration (usfda) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (csssis) caused by gram-positive bacteria, including mrsa (s. aureus, streptococcus agalactiae, s ...201728634536
gas-containing cervical epidural abscess accompanying bacterial meningitis in an adult.gas-containing spinal epidural abscesses are uncommon. moreover, acute spinal epidural abscesses rarely complicate bacterial meningitis in adults. here, we report a rare case of a gas-containing cervical epidural abscess accompanying bacterial meningitis. in spite of aggressive fluid and continuous antibiotic therapy after the isolation of streptococcus anginosus and streptococcus constellatus in the cerebrospinal fluid cultures, the patient showed remaining motor dysfunction and bladder involve ...201728407706
infective endocarditis with left to right intracardiac fistula due to streptococcus anginosus - a rare complication caused by an even rarer bacterium.although infective endocarditis (ie) has been described in reports dating from the renaissance, the diagnosis still challenges and the outcome often surprises. in the course of time, diagnostic criteria have been updated and validated to reduce misdiagnosis. some risk factors and epidemiology have shown dynamic changes since degenerative valvular disease became more predominant in developed countries, and the mean age of the affected population increased. despite streptococci have been being wel ...201728584802
different frequencies of porphyromonas gingivalis infection in cancers of the upper digestive tract.the high incidence rate of multiple carcinomas in the upper digestive tract is often explained in terms of involvement of the same underlying risk factors. it has been reported that the oral bacterium streptococcus anginosus is associated with esophageal, gastric, and pharyngeal cancers. we previously reported occurrence of porphyromonas gingivalis (p. gingivalis) dna in esophagus cancer. in this study, the presence of p. gingivalis in specimens of various types of cancer from the upper digestiv ...201728705771
community composition determines activity of antibiotics against multispecies biofilms.in young cystic fibrosis (cf) patients, staphylococcus aureus is typically the most prevalent organism, while in adults, pseudomonas aeruginosa is the major pathogen. more recently, it was observed that also streptococcus anginosus plays an important role in exacerbations of respiratory symptoms. these species are often coisolated from cf lungs, yet little is known about whether antibiotic killing of one species is influenced by the presence of others. in the present study, we compared the activ ...201728696232
correction: modulation of behaviour and virulence of a high alginate expressing pseudomonas aeruginosa strain from cystic fibrosis by oral commensal bacterium streptococcus anginosus.[this corrects the article doi: 10.1371/journal.pone.0173741.].201728426833
development of a multiplex pcr for identification of β-hemolytic streptococci relevant to human infections and serotype distribution of invasive streptococcus agalactiae in thailand.a multiplex polymerase chain reaction (mpcr) was developed for simultaneous detection (single reaction) of genes specific to five frequent clinically relevant β-hemolytic streptococcal species: streptococcus pyogenes (spy1258), streptococcus agalactiae (cfb and cpn60), streptococcus dysgalactiae subsp. equisimilis (16s-23s intergenic spacer) , s. equi subsp. zooepidemicus (esaa and sord), and streptococcus anginosus group (moac). no cross-reaction was observed with other bacterial species. this ...201728666619
the pyogenic potential of the different streptococcus anginosus group bacterial species: retrospective cohort study.streptococcus anginosus group (sag) bacteria are common causes of pyogenic infections (pis). we examined the association between sag species and the presence of a pi through a retrospective, observational, cohort study, between the years 2009 and 2015. all adults with clinically significant sag infections in one hospital in israel were assessed for association between sag species and the presence of a pi defined as an abscess, empyema, or deep/organ space surgical site infection. risk factors fo ...201728803566
[successful treatment of acute empyema due to rupture of pyogenic liver abscess].cases of rescue after rupture of pyogenic liver abscess into the thorax are rare. here, we report 2 cases of rescue in patients with acute empyema due to rupture of a suppurative abscess into the thorax. case 1:a 61-year-old male had high fever of 39 °c and right abdominal pain. thoracic computed tomography(ct) showed encapsulated pleural effusion in the right thorax and ring-like enhancement in the right liver. the diagnosis was acute empyema caused by rupture of liver abscess. the pathogenic b ...201728790240
pyogenic pericarditis and cardiac tamponade due to streptococcus anginosus in a combat theater.streptococcus anginosus group pericarditis is rare. a 24-year-old male soldier presented for care at a military clinic in afghanistan with shock and cardiac tamponade requiring emergent pericardial drainage and aeromedical evacuation. we review the patient's case, the need for serial pericardial drainage, and the available literature on this disorder.201728470013
spontaneous fracture of the femur due to osteomyelitis caused by the streptococcus anginosus group.a 57-year-old man was admitted because of pain in the right upper leg due to an osteolytic lesion of the femoral bone which was complicated by a spontaneous fracture. at first a malignancy was suspected. however, blood and bone cultures revealed the streptococcus anginosus group. a diagnosis of acute osteomyelitis was made. in spite of extensive antibiotic and surgical treatment the patient developed severe septic shock with multiple organ failure and died. in the case of a pathological fracture ...201728469049
renewal of peritonsillar abscess: impact of the bacterial species of the infection and clinical features of the patient-a prospective comparative aetiological study.to compare the bacterial species and patient clinical features in peritonsillar abscesses between patients who had renewal (renewal group) and those who did not (recovery group).201728464492
splenic abscess caused by streptococcus anginosus following laparoscopic sleeve gastrectomy: a case report of a rare complication of bariatric surgery.splenic abscess as a complication of laparoscopic sleeve gastrectomy (lsg) is rare. there have only been six cases in the literature. in most of these cases, the classic predisposing factors for developing splenic abscess were absent, leading to the hypothesis that transient bacteraemia caused by mucosal disruption during the surgical procedure and splenic ischaemia may play a role. these patients usually present in the late post-operative period with abdominal pain, fever and leucocytosis. the ...201728458877
oesophageal cancer presenting as lemierre's syndrome caused by streptococcus anginosus.a 59-year-old man presented to the emergency department with complaints of dysphagia, right-sided neck swelling, fever and chills. physical examination was remarkable for fever and tender swelling over the right side of the neck. laboratory investigations revealed leucocytosis with neutrophilia. ct of the neck showed right internal jugular vein thrombosis with an overlying abscess and a nodular opacity in the right lung apex with air locules. he underwent surgical drainage of the neck abscess. a ...201728416472
how to become a killer, or is it all accidental? virulence strategies in oral streptococci.streptococci are a diverse group of gram-positive microorganisms sharing common virulence traits and similar strategies to escape the oral niche and establish an infection in other parts of the host organism. invasive infection with oral streptococci is "a perfect storm" that requires the concerted action of multiple biotic and abiotic factors. our understanding of streptococcal pathogenicity and infectivity should probably be less mechanistic and driven not only by the identification of novel v ...201728727895
rapid developing empyema by group f beta streptococcus anginosus group.a 43-year-old male had progressive pleuritic left-sided chest tightness with shortness of breath. he had dental caries and tenderness on palpation of the left lateral chest. complete blood count showed leucocytosis. ct scan of the chest with pulmonary emboli protocol showed multiple pulmonary nodules and nodular pleural thickening at left posterior lateral pleura. forty-eight hours post ctpe scan, ct scan of the chest, abdomen and pelvis displayed right lower lobe consolidation and left-sided pl ...201728705799
fournier's gangrene caused by streptococcus anginosus, a rare etiologic agent. 201728676193
tricuspid valve endocarditis partly due to a penicillin susceptible, ceftriaxone-resistant streptococcus anginosus isolate. 201728594647
unexpected brain finding in pre-autopsy postmortem ct.a case is presented in which pre-autopsy postmortem computed tomography (pmct) revealed an unexpected brain abscess with a related frontal sinusitis and an erosion of the posterior wall of the frontal sinus. pmct findings enabled the forensic pathologists to adapt protective measures during autopsy and protect their health from infection. pre-autopsy pmct has been also useful in the early differential diagnosis procedure. the complementary use of postmortem imaging and autopsy can improve the qu ...201728589523
bacteriostatic effect of simvastatin on selected oral streptococci in vitro.simvastatin is a widely used cholesterol-lowering drug, which has been found to have a number of pleiotropic effects. the aim of this study was to evaluate the antimicrobial effectiveness of simvastatin against selected oral streptococci as determined by the minimum inhibitory concentration (mic).201728566853
[streptococcal anginosus meningitis with a high-level resistance to cephalosporin of third generation]. 201728532641
betel nut chewing, oral premalignant lesions, and the oral microbiome.oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (hpv), and areca (betel) nut. although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. an investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. study participants were recruited from a dental clinic in guam. structured interviews a ...201728225785
leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer.colorectal cancer (crc) is the second leading cause of cancer-associated mortality in the usa. the faecal microbiome may provide non-invasive biomarkers of crc and indicate transition in the adenoma-carcinoma sequence. re-analysing raw sequence and metadata from several studies uniformly, we sought to identify a composite and generalisable microbial marker for crc.201728341746
critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections.tedizolid phosphate has high activity against the gram-positive microorganisms mainly involved in acute bacterial skin and skin structure infections, such as strains of staphylococcus aureus (including methicillin-resistant s. aureus strains and methicillin-sensitive s. aureus strains), streptococcus pyogenes, streptococcus agalactiae, the streptococcus anginosus group, and enterococcus faecalis, including those with some mechanism of resistance limiting the use of linezolid. the area under the ...201728053508
modulation of behaviour and virulence of a high alginate expressing pseudomonas aeruginosa strain from cystic fibrosis by oral commensal bacterium streptococcus anginosus.cystic fibrosis (cf) airways harbour complex and dynamic polymicrobial communities that include many oral bacteria. despite increased knowledge of cf airway microbiomes the interaction between established cf pathogens and other resident microbes and resulting impact on disease progression is poorly understood. previous studies have demonstrated that oral commensal streptococci of the anginosus group (ags) can establish chronic pulmonary infections and become numerically dominant in cf sputa indi ...201728301571
correction for zuñiga-bahamon et al., draft genome sequence of streptococcus anginosus bvi, a new vaginal pathogen candidate. 201728280015
members of a new subgroup of streptococcus anginosus harbor virulence related genes previously observed in streptococcus pyogenes.conventionally categorized as commensals, the streptococci of the species s. anginosus are facultative human pathogens that are difficult to diagnose and often overlooked. furthermore, detailed investigation and diagnosis of s. anginosus infections is hampered by unexplored taxonomy and widely elusive molecular pathogenesis. to explore their pathogenic potential, s. anginosus isolates collected from patients of two geographical locations (vellore, india and leipzig, germany) were subjected to mu ...201728274699
[streptococcus milleri: an unusual cause of skull extensive osteomyelitis in an immunocompetent patient].streptococcus milleri (streptococcus anginosus, intermedius and constellatus) are commensal organisms, which can become pathogenic and cause infection with frequent abscess formation, local or metastatic extension. osteomyelitis of the skull has been rarely reported in this type of infection.201728236536
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