Publications

ethanol reduces tolerance, sensitization, and up-regulation of d2-receptors after subchronic haloperidol.	to study the interrelationships between dopamine d2-receptor density and behavioral responses after chronic treatment with neuroleptics female wistar rats received haloperidol (hp; 14 mg/l), ethanol (etoh; 5 vol.%), a combination of both, or tap water as drinking fluids for one or two weeks. mean intake doses ranged between 1.28 and 1.48 mg/kg/day (hp) and between 3.7 and 4.8 g/kg/day (etoh). hp administered for one or two weeks raised the number of [3h]spiroperidol binding sites in the striatum ...	1990	2217521
[electron microscopic cytochemical study on lectin binding sites in the epiphyseal cartilage-plate of rabbit tibia].	lectin is a common name given to a certain group of hemagglutinating proteins found primarily in plant seeds, which bind specifically to the branching sugar molecules of glycoproteins and glycolipids of the surface of the cells. the author selected 3 kinds of lectin among others. those were concanavalin a (con a) which specifically binds to the alpha-d-mannose, wheat germ agglutinin (wga) which binds to n-acetyl glucosamine, and peanut agglutinin (pna) which binds to beta-d-galactosamine. the lo ...	1990	2134934
lack of pqq dependent glucose dehydrogenase apoenzyme in some acinetobacter spp.	seventy four asaccharolytic strains of acinotobacter were tested for the presence of pqq dependent glucose dehydrogenase apoenzyme. this apoenzyme could not be detected in any of five strains of acinetobacter haemolyticus; it was also lacking in one strain of each a. junii and a. lwoffi.	1990	2176072
glucocorticoid stimulation of fatty acid synthesis in explants of human fetal lung.	we examined the effects of glucocorticoids and thyroid hormone (t3) on fatty acid synthesis, fatty acid composition and fatty acid synthetase activity in explants of human fetal lung (16-23 wk gestation). explants were cultured 1-7 days in the absence (control) or presence of dexamethasone (10 nm) and/or t3 (2 nm). in control explants fatty acid synthesis and fatty acid synthetase activity increased 200% and 455%, respectively, between 1 and 5 days. dexamethasone (10 nm) stimulated fatty acid sy ...	1990	2297514
structure of the 68-kda neurofilament gene and regulation of its expression.	the complete structure of the mouse 68-kda neurofilament (nf-l) gene was elucidated. we cloned cdnas corresponding to 3.5- and 2.3-kb nf-l mrna, including their polyadenylation sites. sequence analysis revealed that these nf-l mrnas arose from the alternative use of two polyadenylation sites in exon 4. promoter analysis using nf-l promoter-beta-galactosidase fusion plasmids determined regions responsible for its basic promoter activity, which were located between -328 and -36 base pairs from the ...	1990	2246261
structural specificity for biological activity of trichostatin a, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in friend leukemia cells.	biological activities of four chemically synthesized trichostatin-related compounds, (r)-trichostatin a, (s)-trichostatin a, (r)-trichostatic acid, and (s)-trichostatic acid, were investigated. assays of differentiation-inducing activity in friend leukemia cells and g2-arresting activity in the cell cycle of normal rat fibroblast cells were used as monitoring systems for comparing the bioactivities of these compounds. the results clearly showed that both of the enantiomers of trichostatic acid h ...	1990	2211374
characterization of activation and deactivation pathways of 4-(n-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (nnk) in rat hepatocytes.	we have characterized the metabolism of 4-(n-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (nnk) in cultured rat hepatocytes and have established the relationship between various metabolic pathways and single-strand breaks (ssb) in dna. metabolism of [5-3h]-nnk by carbonyl reduction, alpha-carbon hydroxylation and pyridine n-oxidation was linear from 0.5 to 6 h with 0.25-2 x 10(6) hepatocytes. using an alkaline elution assay, we observed that nnk induces ssb in dna in a dose- and time-dependent m ...	1991	1855907
head group specificity in the regulation of phosphatidylcholine catabolism in rat hepatocytes.	previous studies have shown that the catabolism of pc is regulated in choline-deficient hepatocytes and the concentration of phosphatidylcholine (pc) might be an important regulatory factor (tijburg, l.b.m., nishimaki-mogami, t. and vance, d.e. (1991) biochim. biophys. acta, 1085, 167-177). in the present study we investigated the head group specificity of the regulation of pc catabolism. supplementation of choline-deficient rat hepatocytes, prelabeled with [3h]choline, with dimethylethanolamine ...	1991	1892886
clinical testing of thermally stimulated cardiovascular oscillations in man.	the study assessed the physiological validity of an automatic thermal stimulation method to induce synchronised oscillations in the neural cardiovascular control system.	1991	1913758
processing of the glycoprotein of feline immunodeficiency virus: effect of inhibitors of glycosylation.	the processing and transport of the envelope glycoprotein complex of feline immunodeficiency virus (fiv) in the persistently infected crandell feline kidney (crfk) cell line were investigated. pulse-chase analyses revealed that the glycoprotein is synthesized as a precursor with an mr of 145,000 (gp145) and is quickly trimmed to a molecule with an mr of 130,000 (gp130). treatment of gp130 with endoglycosidase h (endo h) resulted in a protein with an mr of 75,000, indicating that nearly half the ...	1991	1847441
adrenalin activation of beta 2-adrenoceptors stimulates morphological changes in astrocytes (pituicytes) cultured from adult rat neurohypophyses.	neurohypophysial astrocytes, the pituicytes, are known to undergo morphological changes in vivo in response to stimuli that increase the demand for hormone secretion. similar changes have been induced by beta-adrenergic stimulation both in the isolated, but otherwise intact, neural lobe and in pituicytes cultured from adult rats. since the predominant beta-receptor subtype in the neural lobe is beta 2, we investigated the possibility that beta 2-receptor activation is mainly responsible for the ...	1991	1682016
a nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins.	we have developed a novel nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins. this method is derived from previously described protocols developed for the same purpose by using radioactively labeled dna probes containing protein recognition sequences. this nonradioactive strategy relies upon the use of a small hapten, digoxigenin. fusion proteins expressed from the recombinant bacteriophage lambda gt11/lambda zap are immobilized on nitrocellulose fi ...	1991	1828652
a nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins.	we have developed a novel nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins. this method is derived from previously described protocols developed for the same purpose by using radioactively labeled dna probes containing protein recognition sequences. this nonradioactive strategy relies upon the use of a small hapten, digoxigenin. fusion proteins expressed from the recombinant bacteriophage lambda gt11/lambda zap are immobilized on nitrocellulose fi ...	1991	1828652
inhibitory effect of cimetidine on graft survival of allotransplanted rats submitted to an active-passive enhancement protocol.	the objective of the present study was to determine whether cimetidine, a type-2 histamine receptor antagonist, inhibits the immunological enhancement of allografted rats achieved by treatment with donor antigen plus anti-donor antibody. groups of rats submitted to this active-passive enhancement protocol and treated ip with 30 (apec 30; group i; n = 4) or 60 (apec 60; group ii; n = 8) mg/day cimetidine for 14 days had a significantly shorter graft survival (20.2 +/- 5.1 and 11.1 +/- 2.6 days, r ...	1991	1797288
inhibitory effect of cimetidine on graft survival of allotransplanted rats submitted to an active-passive enhancement protocol.	the objective of the present study was to determine whether cimetidine, a type-2 histamine receptor antagonist, inhibits the immunological enhancement of allografted rats achieved by treatment with donor antigen plus anti-donor antibody. groups of rats submitted to this active-passive enhancement protocol and treated ip with 30 (apec 30; group i; n = 4) or 60 (apec 60; group ii; n = 8) mg/day cimetidine for 14 days had a significantly shorter graft survival (20.2 +/- 5.1 and 11.1 +/- 2.6 days, r ...	1991	1797288
analysis of high psa n-cam expression during mammalian spinal cord and peripheral nervous system development.	using a monoclonal antibody that recognizes specifically a high polysialylated form of n-cam (high psa n-cam), the temporal and spatial expression of this molecule was studied in developing spinal cord and neural crest derivatives of mouse truncal region. temporal expression was analyzed on immunoblots of spinal cord and dorsal root ganglia (drgs) extracts microdissected at different developmental stages. analysis of the ratio of high psa n-cam to total n-cam indicated that sialylation and desia ...	1991	1769342
[anti-inflammatory activities and effect of rhizoma alismatis on immune system].	10 and 20 g/kg ig of rhizoma alismatis (ra) markedly decrease the clearance rate of charcoal particles in mice, but have no significant effect on the weight of immune organs, or on the content of serum antibody hemolysin and immunoglobulin g and the delayed footpad edema induced by sheep red blood cell. the contact dermatitis of mouse pinnae immunized with dinitrochlorobenzene is inhibited by ra when it is given before challenge. in addition, ra 20g/kg suppresses the swelling of mouse rinnae ind ...	1991	1820797
[anti-inflammatory activities and effect of rhizoma alismatis on immune system].	10 and 20 g/kg ig of rhizoma alismatis (ra) markedly decrease the clearance rate of charcoal particles in mice, but have no significant effect on the weight of immune organs, or on the content of serum antibody hemolysin and immunoglobulin g and the delayed footpad edema induced by sheep red blood cell. the contact dermatitis of mouse pinnae immunized with dinitrochlorobenzene is inhibited by ra when it is given before challenge. in addition, ra 20g/kg suppresses the swelling of mouse rinnae ind ...	1991	1820797
ab-interno neodymium:yag versus erbium:yag laser sclerostomies in a rabbit model.	this study was undertaken to determine whether thermally-induced tissue necrosis was a factor in ab-interno contact-laser sclerostomy failure. a rabbit model was used to compare the continuous-wave neodymium (nd):yag with the pulsed erbium (er):yag laser with respect to such failure. laser energy was focused into a fused-silica fiber optic (400 microns) for the nd:yag laser (12 w; 3 to 5 seconds), and into a single-crystal, uncladded sapphire fiber optic (250 microns) for the er:yag laser (7 to ...	1992	1574289
reduced mrna levels for the multidrug-resistance genes in camp-dependent protein kinase mutant cell lines.	we have previously shown that in chinese hamster ovary (cho) cells, a mutant cell line with a defective regulatory subunit (ri) for the camp-dependent protein kinase (abraham et al: mol. cell. biol., 7:3098-3106, 1987), and a transfectant cell line expressing the same mutant kinase, showed increased sensitivity to a number of drugs that are known to be substrates for the multidrug transporter (p-glycoprotein). in the current study we have investigated the mechanism by which camp-dependent protei ...	1992	1352302
characterization of guanosine diphospho-d-mannose dehydrogenase from pseudomonas aeruginosa. structural analysis by limited proteolysis.	alginate is believed to be a major virulence factor in the pathogenicity of pseudomonas aeruginosa in the lungs of patients suffering from cystic fibrosis. guanosine diphospho-d-mannose dehydrogenase (gdpmannose dehydrogenase, ec 1.1.1.132) is a key enzyme in the alginate biosynthetic pathway which catalyzes the oxidation of guanosine diphospho-d-mannose (gdp-d-mannose) to gdp-d-mannuronic acid. in this paper, we report the structural analysis of gmd by limited proteolysis using three different ...	1992	1370473
expression and release of neuroregulators during development: monoamines and neuropeptides.	the turnover of catecholamines (ca) was determined in the adrenal medulla and brain of rat fetuses and pups. in general we found a considerable increase soon after birth. the expression of mrna for ca-synthesizing enzymes was also considerably enhanced in the adrenals shortly after birth. furthermore, we demonstrated increased expression of neuropeptides after birth, increased synthesis of mrna encoding for neuropeptide y in the adrenals 24 h after birth; and considerable activation of the subst ...	1992	1306802
gap-43 mrna localization in the rat hippocampus ca3 field.	gene expression of the axonal growth-associated protein, gap-43, has been studied in the adult rat brain by in situ hybridization histochemistry. this protein is synthesized at high levels in neuronal somata in immature and regenerating neurons, but after establishment of mature synaptic relations its synthesis generally declines sharply, thus providing a marker denoting propensity for exhibiting synaptic plasticity. detailed examination of the distribution of mrna for gap-43 in rat hippocampus ...	1992	1317499
why is the phosphorus content of human milk exceptionally low?	the phosphorus supply of children and adults is adequate, and usually in excess. therefore, it is surprising that in breast-fed infants phosphorus intake is very low. this is very rare among mammals. in infants three pathophysiological mechanisms argue in favour of a low, but adequate phosphorus intake in the presence of a balanced ratio of calcium to phosphorus. a low intestinal phosphorus concentration is an essential condition of an acid ph of the faeces, inhibiting the growth of potentially ...	1992	1435825
interaction between effects of hypoxia and hypercapnia on altering left ventricular relaxation and chamber stiffness in dogs.	left ventricular (lv) isovolumic relaxation and chamber stiffness were examined in dogs to see how hypoxemia and hypercapnia occurring during an acute exacerbation of chronic obstructive lung disease could directly affect diastolic performance. measurements were obtained during baseline (arterial po2 approximately 200 mm hg; pco2 approximately 35 mm hg; ph approximately 7.35), hypoxia (po2 approximately 35 mm hg; pco2 approximately 35 mm hg; ph approximately 7.35), and hypoxia-hypercapnia (po2 a ...	1992	1489118
acupuncture analgesia.	acupuncture-produced surgical analgesia has been demonstrated in a wide variety of species under experimental and clinical circumstances. the main advantage is that no depressant drugs need to be used. the disadvantages of its use are unfamiliarity, the need for special equipment, inconsistent effects, and lack of restraint.	1992	1533972
diagnosis of sickle cell disease in chronically transfused patients.	standard electrophoretic methods for the diagnosis of hemoglobinopathies are confounded in individuals chronically transfused. we present the accurate diagnosis of sickle cell disease in two such transfused patients by the application of polymerase chain reaction technology to analyze patient's hemoglobin beta-chain genes directly.	1992	1550267
total anomalous pulmonary venous connection: surgical correction in a 66-year-old man.	a cyanotic, debilitated 66-year-old man was referred as an emergency because of embolic arterial occlusion of the left lower extremity. subsequent investigation revealed total anomalous pulmonary venous connection. complete surgical correction was accomplished. despite a difficult postoperative hospital course, more than 3 years after operation he continues to experience improved quality of life with better exercise tolerance, freedom from further emboli and symptomatic arrhythmias, and no need ...	1992	1540076
phospholipase c-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(ii).	we have investigated the effect of cis-diamminedichloroplatinum(ii) (cddp) on signal transduction pathways. cddp treatment did not cause any change in the binding of [3h]-phorbol dibutyrate to pc-9 (human lung adenocarcinoma cell line) cells, a measure of protein kinase c activation. however, 2-h cddp treatment (20 micrograms/ml) caused approximately 200% increase in 1,2-sn-diacylglycerol (dag) production and approximately 50% decrease in inositol 1,4,5-triphosphate production. to explore the di ...	1992	1569201
low ph deforms the influenza virus envelope.	influenza virus membrane fusion is induced by low ph, which triggers an irreversible conformational change in the viral haemagglutinin (ha). the result of this change is the extrusion of the ha fusion peptide, after which it may act in the fusion of virus and endosomal membranes. here we describe electron microscopic observations on low ph-treated virus after negative staining or cryo-electron microscopy of virus in the frozen hydrated state. the results indicate a destabilization of the virus m ...	1992	1634881
the hha protein from escherichia coli is highly homologous to the ymoa protein from yersinia enterocolitica.		1992	1484495
volunteers can help patients adjust.		1998	107087
23na-nmr study of the competition of biogenic amines with sodium ion for binding to lasalocid (x-537 a).		1998	106745
[benz(a)pyrene pollution of the atmosphere of a large city].		1999	91547
multiple endocrine adenomatosis (type 1) with cutaneous leiomyomata and cysts of moll.		2000	18161
pancreatic duct obstruction: a new observation during fine needle percutaneous transhepatic cholangiography.		2000	99005
bilirubin: worked out years ago?		2000	384357
[short-term effects of gamma-globulins on sleep organization in epileptic patients (author's transl)].	a study of the effect of gamma-globulins on sleep was conducted in 8 patients aged 1 to 35 years with epilepsy not responding to any of the conventional treatments. two polygraphic recordings were carried out during the 4th and 5th nights following a placebo injection and then an injection of gamma-globulin 16 merieux (1 ml/kg). the short-term effects of the gamma-globulins were : --reduction in percentage of paroxysms, --an acceleration in the electroencephalographic tracings of the different s ...	2001	93297
poison ivy (rhus) dermatitis.		2001	150451
[determination of hva and 5-hiaa in epileptic syndromes in basal conditions and after treatment with probenecid].		2001	95499
studies on blood components of an air-breathing siluroid fish, heteropneustes fossilis (bloch) in relation to body weight.	different haematological parameters have been studied in relation to the body weight of heteropneustes fossil (bloch). the erythrocytes and leucocytes number and haemoglobin concentration increases from lower to higher weight groups. the heart weight also increases along with other blood components. with the unit increase in the body weight of this fish, the heart weight, erythrocytes, leucocytes and haemoglobin increase by a fractional power of 0.85700, 0.13480, 0.13215 and 0.22876, respectivel ...	2001	58809
indium-labelled autologous platelets as diagnostic aid after renal transplantation.		2001	92648
hla markers in six lebanese religious subpopulations.	a total of 315 normal, unrelated individuals from six of the seven principal religious communities of lebanon have been typed for 26 alleles of the a and b loci. the gene, haplotype frequencies and delta values have been calculated. the hla gene frequencies for loci a and b reported in this study are shown to cross moslim-christian lines, but generate a distinguishably different profile for the armenian immigrant subpopulation. this first-level homogeneity which is inconsistent with results earl ...	2001	93316
localization of atpase protein in sarcoplasmic reticulum membrane.		2001	135530
[potentialities of diagnostics and palliative surgery in patients with obstructive jaundice of tumorous origin].	the work deals with the results of treatment of 322 patients with subhepatic jaundice of tumorous origin, who were treated at the clinic of hospital surgery of the kuibyshev medical institute during the recent 15 years. in patients subjected to surgery associated with chemotherapy a longer survival was noted as compared with those without chemotherapy.	2001	92856
morphometric analysis of b2camp induced reverse transformation in synchronized cho cells.	synchronized tranformed and reverse-transformed (by 10(-3) m b2camp) cho-k1 cells, growing adherent to plastic, are characterized by means of geometric and densitometric parameters at the level of both the entire cell and of the nuclei at various time intervals after selective miotic detachment. transformed and reverse-transformed cells triple-stained with feulgen, napthol yellow s, and periodic acid-schiff appeared very similar in terms of integrated optical density (iod), related to either pol ...	2001	95183
[tumor plasminogen activators and their clinical significance].	by means of a radio-immunological method the amount of plasminogen activators released by tumours was determined. the concentrations of tumour plasminogen activators was considerably higher in the venous blood of ovarial tumours than in the peripheral blood. in the uterine fluid the uterus cavity the concentration of plasminogen activator was increased in cases with neoplastic endometrium compared to those with normal endometrium.	2001	94895
echocardiography: pericardial tickening and constrictive pericarditis.	to evaluate the relation between mitral valve motion and left ventricular end-diastolic pressure, the pr-ac interval, an index derived from the electrocardiogram and mitral echogram, and the left ventricular endodiastolic pressure were determined simultaneously in 22 patients undergoing diagnostic cardiac catheterization. intravenous infusion of dextran or administration of nitroglycerin was used to alter left ventricular end-diastolic pressure to determine if there was a predictive relation bet ...	2001	99019
[combination of adriamycin and cyclophosphamide (alone or with other substances) in the treatment of breast cancer].	this paper reviews clinical trials at the university of arizona cancer center which were designed to improve the outcome in breast cancer by utilizing the combination of adriamycin and cyclophosphamide (a--c) alone or with the addition of other agents or modalities. our initial trial in advanced breast cancer with a--c produced an overall objective response rate of 78% in 51 patients with advanced breast cancer without prior chemotherapy. the median duration of disease control was 12 months. sub ...	2001	93257
the money motive.		2001	55542
long-term follow-up (5-12 years) of proliferative diabetic retinopathy treated with xenon arc photocoagulation.		2001	95033
[congenital diverticulum of the left ventricle].		2002	138802
plasma camp and renin in diabetics during insulin induced hypoglycemia.		2002	187538
[outcome of abutment for dysplasia of the acetabulum and for dysplasia associated with coxa valga].		2002	137478
[100th graduation of veterinary physicians].		2002	129911
[salt fluoridation in 4 colombian communities. vii. relationship between various nutrients and dental caries].		2002	127591
adenosine diphosphate binding to sodium-plus-potassium ion-dependent adenosine triphosphatase. the role of lipid in the nucleotide-potassium ion interplay.	delipidated dogfish rectal-gland na++k+-atpase (na++k+-dependent adenosine triphosphatase), almost devoid of hydrolytic activity, is able to bind about 2nmol of adp/mg of protein. the "affinity" of delipidated enzyme for adp is not affected by k+ in concentrations that greatly decrease the "affinity" of native na++k+-atpase. the k+-sensitivity of the adp binding is in part restored by relipidation with dioleoyl phosphatidylcholine.	2002	137721
hereditary hemolytic anemia with erythrocyte phosphofructokinase deficiency: studies of some properties of erythrocyte and muscle enzyme.	a case of hereditary nonspherocytic hemolytic anemia associated with partial erythrocyte pfk deficiency without muscular symptoms is reported: erythrocyte enzyme activity in the propositus was 60% of normal. kinetic studies of erythrocyte pfk revealed increased sensitivity to atp inhibition and decreased sensitivity to citrate inhibition. muscle pfk from the patient had a normal enzymatic activity, but was highly unstable to heat, dilution without stabilizer and urea; furthermore its starch gel ...	2002	129430
coffee shop management gains favor.		2003	153454
a simple, specific, radioisotopic assay for 5'-nucleotidase.		2003	165748
[sanitary water quality on farms and disinfection methods].		2003	151369
[2 cases of hepatorenal polycystosis].	the authors report two cases of polycystic liver andkidney in two women. they were unusual in that the liver first gave risr to symptoms and the renal lesions were completely latent. both hepatic and renal lesions were well tolerated in spite of hepatomegally. they emphasize the interest of laparoscopy and biopsy of the liver under direct vision, and selective aortography, in the diagnosis. they discuss the basic differences between polycystic liver and kidney in adults, from that in children or ...	2003	166438
[anterior antehypaphyseal insufficiecency in the elderly].	the authors report 4 personal cases, and analyse 18 cases of anterior pituitary insufficiency in the elderly found in the world literature. the initial symptoms are not specific and are difficult to interpret. they are frequently attributed to physiological ageing. in the absence of early diagnois, the patient may become comatose, this coma is often irreversible in spite of hormone treatment. in 60% of cases, the cause of the pituitary failure was not found. in the onset of the latter, the role ...	2003	166436
mechanism of immunosuppression of progesterone on maternal lymphocyte activation during pregnancy.		2003	156222
effects of divalent cations on dynein cross bridging and ciliary microtubule sliding.	we recently demonstrated that addition of the divalent cation mg++ to demembranated cilia causes the dynein arms to attach uniformly to the b subfibers. we have now studied the dose-dependent relationship between mg++ or ca++ and dynein bridging frequencies and microtubule sliding in cilia isolated from tetrahymena. both cations promote efficient dynein bridging. mg++-induced bridges become saturated at 3 mm while ca++-induced bridges become saturated at 2 mm. double reciprocal plots of percent ...	2003	156731
[in memoriam s. sivák m.d. (29 july 1930- 14 january 1978)].		2003	151600
[relation between endocrinology and psychiatry. some recent developments].	relations between endocrinology and psychiatry are developing in two main directions: behavioural effects of hormones. after the effects of peripheral hormones, recent works are concerned with a.c.t.h. and antidiuretic hormone (which interfere with memory process) and with hypothalamic peptides (which might have psychotropic properties, independant of their endocrine regulation function). -correlations between psychiatric syndroms and endocrine disorders. in some mentally depressed patients, dis ...	2003	165466
acute viral respiratory infections in children.		2004	506792
[ige determination (rist, prist and others)].		2004	490927
inducibility of metallothionein biosynthesis in cultured normal and menkes kinky hair disease fibroblasts: effects of copper and cadmium.	metallothionein biosynthesis is not induced by extracellular copper in menkes kinky hair disease (mkhd) or in normal cultured fibroblasts under the conditions of these experiments. in the presence of copper, mkhd fibroblasts also incorporated less cysteine than did normal fibroblasts. extracellular cadmium greatly enhanced the uptake of cysteine in both normal and mkhd cultures. by the technique of polyacrylamide gel electrophoresis, it was demonstrated that metallothionein is induced by cadmium ...	2004	471576
[low-molecular weight nuclear rna's].		2004	395786
pathogenetic mechanisms in legionnaires' disease.		2004	519205
[endocrinological diagnosis of pituitary neoplasms].		2004	438581
the construction of a membrane slide support for the observation of living cells.	the construction of a slide for examining living cells under the microscope under controlled conditions is described.	2004	423235
creatine kinase (ec-no.2.7.3.2) and creatine kinase isoenzymes during pregnancy and labor and in the cord blood.	total ck and ck isoenzyme activity in serum was investigated during pregnancy, labor and after delivery as well as in cord blood. total ck was decreased in the second trimester of pregnancy but increased in late pregnancy. low ck-mb activity in serum was found in patients with early labor pains. ck-bb activity could never be detected during pregnancy. total ck and isoenzyme activity increased after delivery. the rise of total ck and ck-mb in maternal serum is directly correlated with the followi ...	2004	535161
arrest of alveolar multiplication in kyphoscoliosis.	a detailed morphometric study of the lungs of an adult patient with severe kyphoscoliosis of childhood onset is reported. the number of alveoli was less than the normal adult range and corresponded to the predicted values for a 12-month-old infant. this may have been a result of both premature cessation of alveolar multiplication as well as alveolar atrophy. the alveolar size was larger than normal suggesting that after cessation of alveolar multiplication further lung growth occurred by an exce ...	2004	523187
some historical perspectives on dentistry, the american college of dentists and professionalism.		2004	321498
[difficulty of regulating maximum amount of any chemical in perfumes (author's transl)].		2004	539743
[thromboembolism of the mesenteric vessles].		2004	1133941
[hemorrhagic complications of cirrhosis: chronic hypercoagulability of the plasma from diffuse hepatic lesions (author's transl)].		2004	487896
rhodopsin in model membranes.		2004	383153
acoustic chiasm v: inhibition and excitation in the ipsilateral and contralateral projections of lso.	when this series of experiments was begun in 1984, the activity of each lateral superior olive (lso) in the mammalian hindbrain was known to encode the hemifield of acoustic space containing a sound source. however, the almost random bilaterality of its ascending projections seemed to jumble that identification before reaching the midbrain. at the same time, electrophysiological studies of lso and its efferent target in the inferior colliculus, along with the strictly contralateral deficits in s ...	2005	1317390
gangliosides and neuronal-astrocytic interactions.		2005	1287722
trade-off between gestational age and miscarriage risk of prenatal testing: does it vary according to genetic risk?	it has been generally assumed that as genetic risk rises, so the higher procedure-related miscarriage rates of diagnostic tests done earlier in gestation become more acceptable. to test the hypothesis a decision tree was used, in which the only differences between two tests a and b were that a was carried out earlier in pregnancy and was more likely to cause miscarriage. over a wide range of rankings for the three outcomes (procedure-related miscarriage of a normal baby, early termination of pre ...	2005	1978126
[lumbosacral radiculography with dimer-x and amipaque. advantages, side effects and possible late complications].		2005	551604
[is appendicitis still a problem in our health services?].		2005	1214553
the aching mouth and the aching psyche.		2005	1074368
[mitral valve prolapse and arrhythmia: study using dynamic 24-hour ecg in 104 patients].		2005	548337
questions about inhaled beta 2-adrenoceptor agonists in asthma.	the safety of the most widely prescribed antiasthma drugs, beta 2-adrenoceptor agonists, has recently been questioned. issues such as their suitability for long-term and regular prophylactic use are addressed in this comment article by peter barnes and fan chung, who examine the possibility that the beta 2-agonists themselves contribute to worsening symptoms in asthma patients, thus setting up a vicious circle with greater use of the drugs. they conclude that it would be prudent to restrict the ...	2005	1347433
[in memory of jirŕ kruml, m.d., c.sc].		2005	1104202
authority orientations of police officers.		2005	1176428
patterns of substance use among methadone maintenance patients. indicators of outcome.	critics often cite the use of illicit drugs among methadone maintenance patients as evidence of this treatment modality's failure. the fact that methadone maintenance treatment does not lead quickly to abstinence in most clients can be a disappointment to treatment professionals and the public. by studying a cohort of 41 patients for their first year in a methadone maintenance program, this study revealed significant trends of diminished narcotic and cocaine use. however, increased benzodiazepin ...	2005	1324987
hyperpolarizing photoreceptors in the eye of a primitive chordate, salpa democratica.		2005	1198931
pittfalls in the diagnosis of endocrine exophthalmy.		2005	1242208
effect of altitude relocations upon aado2 at rest and during exercise.	the supine pulmonary venous admixture (shunt) has been measured at cerro de pasco, 4,350 m altitude in eight subjects native to high altitude (han) under resting condition. alveolar-arterial o2 tension difference (aado2) was also determined at rest and during exercise. the same subjects were studied again after 10 days' sojourn at sea level in lima at 150 m altitude. they were compared with four subjects from sea level (sln) who were studied first at lima and after 2 and 10 days at cerro de pasc ...	2005	1176413
patterns of substance use among methadone maintenance patients. indicators of outcome.	critics often cite the use of illicit drugs among methadone maintenance patients as evidence of this treatment modality's failure. the fact that methadone maintenance treatment does not lead quickly to abstinence in most clients can be a disappointment to treatment professionals and the public. by studying a cohort of 41 patients for their first year in a methadone maintenance program, this study revealed significant trends of diminished narcotic and cocaine use. however, increased benzodiazepin ...	2005	1324987
[traumatic cataract and intra-ocular lens].		2005	1236649
[production of tropane alkaloids in tissue cultures (author's transl)].		2005	1187871
pattern and depth discrimination from random dot stereograms.	the discrimination of depth and pattern was investigated using random dot stereograms. for all four subjects, the psychometric function for depth judgments (probability of correct response) was clearly superior to pattern judgments over a range of ten crossed or uncrossed binocular disparity values. degrading the visual images, either monocularly or binocularly, with various convex lens power (fogging lenses) reduced both depth and pattern discrimination across all disparity values, rather than ...	2005	1130488
failure to consult specialist.		2005	1173090