Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| leukotriene b4 omega-oxidation by human polymorphonuclear leukocytes is inhibited by pyocyanin, a phenazine derivative produced by pseudomonas aeruginosa. | human polymorphonuclear leukocytes (pmnl) metabolize the potent chemotaxin leukotriene b4 (ltb4) by omega-oxidation to 20-hydroxyl-ltb4 and 20-carboxy-ltb4. the ability of unstimulated human pmnl to metabolize exogenous ltb4 was found to be inhibited by pyocyanin, a phenazine derivative produced by pseudomonas aeruginosa, in a dose-dependent manner. 1-hydroxyphenazine (1-ohp), a metabolite of pyocyanin, was not inhibitory under identical conditions. the initial enzymic step in the conversion of ... | 1992 | 1316878 |
| alpha 2-adrenoceptor density in forebrain areas of zucker rats: no effect of genetic obesity or antiglucocorticoid treatment. | the density of alpha 2-adrenoceptors was determined in different forebrain regions of lean and obese zucker rats by para-[125i]iodoclonidine ([125i]pic) receptor autoradiography. no significant differences were observed between the zucker phenotypes in the density of alpha 2-adrenoceptors in any brain areas examined. four days treatment with the antiglucocorticoid mifepristone (ru 38486) did not affect [125i]pic-binding. it is concluded that the hyperphagia and abnormal corticosterone secretion ... | 1992 | 1322226 |
| imaging of the knee. | acute and chronic knee dysfunction is a common clinical problem faced by physicians treating patients with musculoskeletal disorders. while standard roentgenograms provide most of the information needed to assess these disorders, the role of magnetic resonance imaging (mri) is rapidly increasing in the diagnostic evaluation of soft-tissue, ligament, tendon, and osseous abnormalities. this article focuses on the role of mri in the evaluation of disorders of the knee. | 2005 | 1343573 |
| hypertension, in black and white. | 2006 | 1347368 | |
| characterization of guanosine diphospho-d-mannose dehydrogenase from pseudomonas aeruginosa. structural analysis by limited proteolysis. | alginate is believed to be a major virulence factor in the pathogenicity of pseudomonas aeruginosa in the lungs of patients suffering from cystic fibrosis. guanosine diphospho-d-mannose dehydrogenase (gdpmannose dehydrogenase, ec 1.1.1.132) is a key enzyme in the alginate biosynthetic pathway which catalyzes the oxidation of guanosine diphospho-d-mannose (gdp-d-mannose) to gdp-d-mannuronic acid. in this paper, we report the structural analysis of gmd by limited proteolysis using three different ... | 1992 | 1370473 |
| biochemical and functional characterization of the leucocyte tyrosine phosphatase cd45 (cd45ro, 180 kd) from human neutrophils. in vivo upregulation of cd45ro plasma membrane expression on patients undergoing haemodialysis. | the biochemical and functional characterization, and the regulation of plasma membrane expression of the leucocyte tyrosine phosphatase cd45, have been investigated in neutrophils from healthy donors and patients undergoing haemodialysis. cd45 proteins of 180 kd and 130-150 kd were precipitated from neutrophils from both healthy subjects and haemodialysed patients. prolonged storing, as well as trypsin treatment of samples containing the 180-kd cd45 protein, generated the 130-150-kd polypeptides ... | 1992 | 1370931 |
| [sample preparation for pcr from pathological specimens]. | 2006 | 1383581 | |
| a demonstration that breast cancer recurrence can be predicted by neural network analysis. | neural network analysis, a form of artificial intelligence, was successfully used to predict the clinical outcome of node-positive breast cancer patients. a neural network was trained to predict clinical outcome using prognostic information from 1008 patients. during training, the network received as input information tumor hormone receptor status, dna index and s-phase determination by flow cytometry, tumor size, number of axillary lymph nodes involved with tumor, and age of the patient, as wel ... | 2005 | 1391974 |
| [changes in auriculoventricular conduction due to the effect of ethanol]. | transcoronary ablation of atrioventricular conduction by dehydrated alcohol was attempted in one patient with refractory ectopic atrial tachycardia. ethanol (1.5 ml) was delivered after selective catheterization of the atrioventricular nodal artery in a patient in whom the artery could be identified by cineangiography. the mean creatine kinase (mb fraction) at four hour to six hour after ablation was 40 u. no electrocardiographic qrs changes was seen. the procedure was successful. the patient is ... | 2006 | 1457004 |
| mouse hypersensitivity pneumonitis: depletion of nk cells abrogates the spontaneous regression phase and leads to massive fibrosis. | the contribution of natural killer cells (nk) in the progression of mouse hypersensitivity pneumonitis induced by repeated intranasal instillations with the thermophilic actinomycete faeni rectivirgula was examined. these instillations determined a very large increase in the lung index (ca. twofold at 3 weeks), used as a measure of inflammation. in addition, this instillation was associated with a tenfold increase in the number of cells recovered in the bronchoalveolar lavage (bal) at 3 weeks an ... | 1992 | 1468409 |
| [tracheopathia osteoplastica. a case report]. | 2006 | 1475434 | |
| antibacterial peptides designed as analogs or hybrids of cecropins and melittin. | eight new analogs of cecropin a, two new analogs of melittin and 30 hybrid peptides containing sequences from cecropins and melittin have been synthesized. the lengths of the peptides have varied from 37 residues (the length of cecropin a) to 18 residues. the peptides have been assayed for lysis of sheep red blood cells and for antibacterial activity against two gram negative and three gram positive bacteria. the best analogs of cecropin a maintained the anti-escherichia coli activity of the par ... | 1992 | 1483838 |
| adoptive immunotherapy of cancer: biological response modifiers and cytotoxic cell therapy. | immunotherapy has been developed for the treatment of metastatic cancers refractory to conventional therapies. immunotherapy utilizes immune cells and/or biological response modifiers (brms) to induce an anti-tumor response mediated by the patient's immune system. brms, including lymphokines and cytokines, are used as single agents or in combination for cancer therapy. some brms, particularly interleukin 2 (il-2), can activate and expand in vitro lymphocytes with anti-tumor reactivity which will ... | 2006 | 1524952 |
| [laparoscopic vascular exclusion of complicated uterine leiomyoma]. | 2006 | 1533926 | |
| [chronic constipation in children caused by "sigma elongatum"?]. | 2006 | 1544339 | |
| the carpal tunnel syndrome: part ii. | the carpal tunnel syndrome is a compression of the median nerve within the carpal tunnel with very specific signs and symptoms. anatomical dissection of 156 wrists is presented and then the authors compare their findings with the findings of other investigators. the purpose of this article is not to present results but rather to discuss the anatomic entities involved with the syndrome and to present the open treatment modality. | 2006 | 1550309 |
| changes of right ventricular size and function in neonates after valvotomy for pulmonary atresia or critical pulmonary stenosis and intact ventricular septum. | right ventricular end-diastolic and stroke volumes were calculated from orthogonal subcostal echocardiographic images in 24 neonates (mean weight +/- sd 3.4 +/- 0.4 kg) with pulmonary atresia (n = 18) or critical pulmonary stenosis (n = 6) and intact ventricular septum before and at an average of 5 days and then 19 days after pulmonary valvotomy. the preoperative echocardiographic volume determinations were compared with the respective angiographic determinations. in addition, the endocardial ar ... | 2006 | 1552090 |
| [local meeting series--a model for continuing education of the general practice staff]. | during the period january 1987 to june 1990 28 educational afternoon meetings were held for the office staff and nurses in general practice in bodø, as well as for the nurses in the bodø emergency clinic/service. office staff and nurses in the occupational health service were also invited, bringing the number up to 42. on average 40.0% of the invited persons attended the meetings. each meeting lasted 2 hours. the number attending the last meetings was so few that the series was discontinued. how ... | 2006 | 1557764 |
| use of an enzyme-linked immunosorbent assay to monitor the control of staphylococcus aureus mastitis. | conventional culture methods were used to evaluate the ability of an elisa to identify staphylococcus aureus imi. the test was 96% accurate; sensitivity was 90%, and specificity was 97%. the test was used to screen preserved milk samples rapidly in 10 cooperator herds. prevalence of imi was greater than 10% in 6 herds at the first test. average prevalence of cows scoring +2 (suspect) and +3 (positive) was 12.6%. prevalence declined during the 12-mo study. incidence of new imi decreased from 7.9% ... | 1992 | 1560137 |
| schizophrenia: gender and familial risk. | the morbid risks for schizophrenia and any nonaffective psychosis in the first degree relatives of male and female schizophrenic probands were compared utilizing cox proportional hazards models. the schizophrenic probands (275 male; 106 female) were drawn from a larger sample of hospitalized patients obtained by systematically screening all psychiatric admissions to 15 facilities over a six-year period. proband diagnoses (dsm-iii) were based on a direct assessment of the patient and a review of ... | 2006 | 1560406 |
| isolation of monocytic serine esterase and evaluation of its proteolytic activity. | monocytes are characterized by high activity of alpha-naphthyl acetate esterase (anae), distinguishing them from all other blood cells. the physiological function of this monocyte marker enzyme has not yet been elucidated. in this study anae's potential proteolytic activity was analyzed because serine esterases/proteases can function as effector molecules in cell-mediated cytotoxicity and because monocytes-macrophages are known to exert cytotoxic effects on tumor cells. this enzyme was purified ... | 2006 | 1564403 |
| lower extremity reconstruction using a long-cryopreserved venous allograft for free flap venous outflow. | vein grafts are used frequently in microvascular surgery, but an adequate supply of autogenous veins is not always available. the search for an ideal substitute for autogenous vein continues. we present a case of lower extremity reconstruction made difficult by lack of suitable autogenous vein for venous outflow from a rectus abdominus free flap. a 36 cm cryopreserved allograft saphenous vein was used on an emergency basis for this problem. | 2006 | 1569881 |
| ab-interno neodymium:yag versus erbium:yag laser sclerostomies in a rabbit model. | this study was undertaken to determine whether thermally-induced tissue necrosis was a factor in ab-interno contact-laser sclerostomy failure. a rabbit model was used to compare the continuous-wave neodymium (nd):yag with the pulsed erbium (er):yag laser with respect to such failure. laser energy was focused into a fused-silica fiber optic (400 microns) for the nd:yag laser (12 w; 3 to 5 seconds), and into a single-crystal, uncladded sapphire fiber optic (250 microns) for the er:yag laser (7 to ... | 1992 | 1574289 |
| tuberculosis and malnourished children. | 2006 | 1604731 | |
| antagonism of the motor effects of cgrp and of capsaicin on the guinea pig ileum by human cgrp8-37. | 1992 | 1637118 | |
| proceedings of the 3rd north sea conference on periodontology. maastricht, the netherlands, 16-19 may 1990. | 2006 | 1679767 | |
| adrenalin activation of beta 2-adrenoceptors stimulates morphological changes in astrocytes (pituicytes) cultured from adult rat neurohypophyses. | neurohypophysial astrocytes, the pituicytes, are known to undergo morphological changes in vivo in response to stimuli that increase the demand for hormone secretion. similar changes have been induced by beta-adrenergic stimulation both in the isolated, but otherwise intact, neural lobe and in pituicytes cultured from adult rats. since the predominant beta-receptor subtype in the neural lobe is beta 2, we investigated the possibility that beta 2-receptor activation is mainly responsible for the ... | 1991 | 1682016 |
| comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus. | three analogs of thymidine, d4t [2',3'-didehydro-2',3'-dideoxythymidine; 1-(2,3-dideoxy-beta-d-glyceropent-2-enofuranosyl)thymine], fddt (3'-fluoro-3'-deoxythymidine), and azt (3'-azido-3'-deoxythymidine), were compared in biological tests designed to assess their potential utility as anti-human immunodeficiency virus (hiv) agents. the in vitro potencies of these compounds against hiv infection in cem cells were measured, with fddt and azt being more potent than d4t. the cytotoxicities of d4t, f ... | 1990 | 1693057 |
| lack of correlation between the coupling interval of ventricular premature beats and the preceding cycle length. | the accepted variation of 80-120 ms in the coupling interval of non-parasystolic ventricular premature beats has been linked to the duration of the preceding cycle length, but a lack of correlation between these factors has often been found. as a result, there is no explanation for variations in the coupling interval of such ventricular premature beats. to analyze the influence of the preceding cycle length on the coupling interval of isolated ventricular premature beats throughout an entire day ... | 2006 | 1716169 |
| [leiomyosarcoma of the right ventricle. report of a case and review of the literature]. | primary cardiac leiomyosarcoma is a very rare condition. only 15 cases have been reported in the literature. we report the case of a 27 year old man admitted to hospital for chest pain in march 1985. echocardiography showed a right ventricular tumour which was completely resected at surgery. the diagnosis of leiomyosarcoma was confirmed by histological examination. after 22 months follow-up, the patient was still alive despite pulmonary metastases. the diagnosis of cardiac tumour used to be made ... | 1991 | 1759901 |
| glucose and glutamine metabolism in rat macrophages: enhanced glycolysis and unaltered glutaminolysis in spontaneously diabetic bb rats. | metabolism of glutamine (gln, 2 mm) and glucose (5 mm) was studied in vitro in isolated resident peritoneal macrophages from both normal (bbn) and spontaneously diabetic bb (bbd) rats. the major products from gln were ammonia, glutamate, co2 and to a lesser extent aspartate. glucose decreased (p less than 0.01) the production of ammonia, co2 and aspartate from gln by 34-60%, but had no effect on the amount of glutamate accumulated. the major products from glucose were lactate and to a much lesse ... | 1991 | 1764469 |
| effect of spectrin on structure properties of lipid bilayers formed from mixtures of phospholipids. fluorescence and microcalorimetric studies. | effect of spectrin from human erythrocytes on structure properties of lipid bilayers formed from a mixture of phosphatidylethanolamine/phosphatidylserine (pe/ps) and/or phosphatidylethanolamine/phosphatidylcholine (pe/pc) was studied with the use of fluorescence and microcalorimetric methods. spectrin did not affect the order parameter of lipids in pe/ps vesicles. however, spectrin binding to liposomes did influence temperature, half-width and enthalpy of phase transitions in mixtures of dimyris ... | 1991 | 1769515 |
| [preoperative risk estimation and drug therapy in chronic heart insufficiency]. | 2006 | 1779584 | |
| percutaneous discectomy using onik's method: 3 years' experience. | a total of 234 patients treated by percutaneous discectomy at 237 levels and followed-up between 11 months and 3 years 4 months showed an overall success rate of about 75%. in a subgroup of 112 of these patients rechecked for a second time, the clinical results remain consistently good even 24 months after surgery. in a special group of 28 patients who complained only of low back pain, percutaneous discectomy achieved a success rate of 85.7%. complications consisted of one disc infection which c ... | 2006 | 1780054 |
| [congenital insufficiency of the distal support function of the first ray of the foot]. | five patients with congenital deficiency of antero-medial support have been examined and treated at the hôpital cantonal, geneva. the main symptoms of these patients were global metatarsalgia and a dorsal bunion. all lesions were bilateral. four of the patients had a localised dyslatia of the first ray, whereas one of them suffered from a nail patella syndrome. in two patients there was a hypoplastic first metatarsal, whereas in three others the first metatarsal was normal but too elevated under ... | 2007 | 1805442 |
| [lifestyle and reproductive situations of adolescent girls in large cities]. | an analysis is made of a sociological interview survey of teenage girls residing and attending educational establishments in one of the moscow regions. teenage girls' views on some issues of future family life have been identified. it has been found that there is a wide prevalence of harmful habits among these populations, the majority of girls have a sexual experience along with low culture of sexual behavior and healthy lifestyle habits. | 2007 | 1838436 |
| magnetic maps in pigeons. | the homing of racing pigeons is often slowed down on days of high sun-spot activity or variability in the earth's magnetic field. the orientation of ring-billed gull chicks as well as the vanishing bearings of homing pigeons also seem to change in response to variability in the earth's magnetic field. furthermore, homing pigeons released under sunny skies at locations where the earth's magnetic field is distributed are disoriented, yet pigeons equipped with devices that change the magnetic field ... | 1991 | 1838522 |
| processing of the glycoprotein of feline immunodeficiency virus: effect of inhibitors of glycosylation. | the processing and transport of the envelope glycoprotein complex of feline immunodeficiency virus (fiv) in the persistently infected crandell feline kidney (crfk) cell line were investigated. pulse-chase analyses revealed that the glycoprotein is synthesized as a precursor with an mr of 145,000 (gp145) and is quickly trimmed to a molecule with an mr of 130,000 (gp130). treatment of gp130 with endoglycosidase h (endo h) resulted in a protein with an mr of 75,000, indicating that nearly half the ... | 1991 | 1847441 |
| a monoclonal antibody against the sulfidopeptide leukotrienes ltc4, ltd4 and lte4. | a monoclonal antibody (1a-ldr1) against sulfidopeptide leukotrienes (lt) is described. the mab shows a nearly identical detection limit of about 0.04 ng for ltc4, ltd4, lte4 and naclte4 in standard fluid phase ria. steric modifications, however, diminish the sensitivity, as determined for the examples 5-epi-ltc4, 6-epi-ltc4, 5,6-epi-ltc4 and 11-trans-ltc4. no crossreactivity could be observed for ltb4. crossreactions with components of the lt peptide chain such as l-cysteine or glutathione, as w ... | 1991 | 1847833 |
| regulation of alcohol consumption by the renin-angiotensin system: a review of recent findings and a possible mechanism of action. | the renin-angiotensin system has traditionally been associated with the regulation of fluid and electrolyte balance. in this review we summarize the data which ascribes a completely new function to this system, i.e., the regulation of alcohol consumption. in addition, we suggest a possible mechanism for this effect based on the concept of a satiety or stop process. the approach taken was to examine the effect on alcohol intake of a wide variety of drug, genetic, dietary, surgical and neurosurgic ... | 2007 | 1852316 |
| the effect of chronic orthopedic infection on quality of life. | the patient with chronic orthopedic infection presents a unique challenge to the orthopedic surgeon. the orthopedic surgeon must not only possess an expertise in constantly evolving diagnostic and treatment techniques but also be able to identify numerous related problems and direct the patient in receiving the most appropriate treatment. this demands a commitment of time by the treating surgeon to the individual patient to properly assess the need for support, the extent of psychologic distress ... | 2007 | 1852430 |
| body composition of low-birth-weight infants determined by using bioelectrical resistance and reactance. | we tested the hypothesis that bioelectrical resistance and reactance are indices of total body water (tbw) and extracellular water (ecw), respectively. infants less than 2500 g in birth weight were studied while less than 24 h old and at 4-7 d of age. tbw (n = 32) was measured by h2(18)o dilution and ecw (n = 34), by bromide dilution. measurements were made by using an impedance plethysmograph from each of four electrode pairs. bioelectrical resistance correlated inversely with tbw (r = -0.683). ... | 2007 | 1858693 |
| effects of prolonged inhalation of n-formyl-methionyl-leucyl-phenylalanine in rabbits. | on the basis of its potent proinflammatory and spasmogenic effects, n-formyl-methionyl-leucyl-phenylalanine (fmlp), a bacterial oligopeptide, is a putative mediator of bronchoconstriction and airway inflammation during bacterial bronchial infection. however, after an fmlp dose-response curve in rabbits, tachyphylaxis to a second challenge was seen in some rabbits and airway inflammation was absent. this study was designed to reproduce the more prolonged airway exposure to fmlp that may occur dur ... | 1991 | 1885438 |
| esophageal epithelial defense against acid injury. | the esophagus is lined with a stratified squamous epithelium. this epithelium, like that of stomach and duodenum, is able to resist damage even on continuous exposure to luminal acid. the intrinsic epithelial defenses against acid injury in the esophagus can be labeled "tissue resistance." tissue resistance is not a single factor but a number of structural and functional elements within the epithelium that interact in a dynamic way to provide protection. this article enumerates the components of ... | 2007 | 1885898 |
| predominant expression of lambda light chain in adult cases with non-t-cell acute lymphocytic and chronic myelogenous leukemia in lymphoid blast crisis. | the authors investigated cytoplasmic immunoglobulins of the leukemic cells from 20 adult cases with non-t-cell acute lymphocytic leukemia (all) and from three cases with chronic myelogenous leukemia in lymphoid blast crisis using immunoelectron microscopy. they also studied these cases using various monoclonal antibodies. of the 23 examined cases, nine were negative for both heavy and light chains of immunoglobulins; the authors defined these as common all. two cases were positive for the mu cha ... | 2007 | 1906773 |
| modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion. | the value of chemopreventive agents for reducing human response to mycotoxins and n-nitrosamines remains uncertain, especially since many such agents also can act as tumour promoters. indole-3-carbinol (i3c) from cruciferous vegetables can inhibit dna adduction and hepatocarcinogenesis induced by aflatoxin b1 (afb1) or n-nitroso-diethylamine in trout if given before and with the carcinogen but promotes carcinogenesis when given after initiation. similar results have been obtained with i3c and af ... | 1991 | 1906835 |
| hyperperfusion and enhanced metabolic state of the brain during sudden lowering of the cutaneous temperature in rats. | forty-eight anesthetized and artificially ventilated rats were pretreated with the ganglion blocking agent, pentolinium (5 mg/kg, i.v.), followed by continuous phenylephrine infusion for maintenance of normotension. the rats were subjected to mock treatment (16 rats), to sudden exposure to thermoneutral water (34-36 degrees c, 16 rats), or to cold water (16 degrees c, 16 rats). the latter treatment lowered the cutaneous temperature to 25-30 degrees c. neither one of these treatments produced any ... | 1991 | 1940032 |
| tympanic membrane retraction pockets. etiology, pathogeny, treatment. | the author describes the morphological behaviour of the tympanic membrane, undergoing long term negative pressure in the middle ear cavities. he explains the viscoelastic properties of the tympanic membrane lamina propria, in cases of retraction pockets. he analyses the preferential weakness of some well localized parts of the tympanic membrane and defends an accurate treatment to avoid this pathology. | 2007 | 1950545 |
| measurement of attitudes and behaviors in public health surveys. | we divided 900 general practitioners into two groups: one group received a questionnaire measuring both attitudes and behaviors toward preventive aspects of medical care, while the other received two separate questionnaires--one measuring behaviors, and one measuring attitudes. response rates of the two groups were similar. respondents in the first group retrieved their answer to the attitudinal items when responding to behavioral items, increasing the correlations between attitudes and behavior ... | 2007 | 1983905 |
| helicobacter nemestrinae sp. nov., a spiral bacterium found in the stomach of a pigtailed macaque (macaca nemestrina) | a new microaerophilic, spirally curved, rod-shaped bacterium was isolated from the gastric mucosa of a pigtailed macaque (macaca nemestrina). the gram-negative cells of this bacterium are oxidase, catalase, and urease positive and strongly resemble helicobacter pylori (campylobacter pylori) cells. like h. pylori, this organism does not metabolize glucose, does not reduce nitrate or produce indole, does not produce h2s from triple sugar iron agar, does not hydrolyze hippurate or esculin, and does ... | 1991 | 1995031 |
| secondary external-beam radiotherapy and hyperthermia for local recurrence after 125-iodine implantation in adenocarcinoma of the prostate. | at stanford, six patients underwent a course of external radiotherapy after local recurrence following 125-iodine implantation. four of the six patients also received concomitant hyperthermia. four patients were initially managed with hormonal manipulation at time of local relapse and subsequently received external beam radiotherapy with or without hyperthermia. the hyperthermia was non-invasively induced using an annular phased array radiative electromagnetic system. treatment was well tolerate ... | 2007 | 1995540 |
| simultaneous assessment of inflammation and epidermal proliferation in psoriatic plaques during long-term treatment with the vitamin d3 analogue mc903: modulations and interrelations. | the influence of topical application of mc903, an analogue of 1 alpha,25-dihydroxyvitamin d3, on psoriatic plaques was investigated during a long-term treatment study. the parameters for epidermal growth and for inflammation were assessed on frozen sections using immunohistochemical methods to elucidate their modulations in time and the interrelations between the different cell types involved during treatment with mc903. biopsies were taken before and after 1, 2, 4 and 12 weeks of treatment. mon ... | 2007 | 2018728 |
| laboratory information systems from a perspective of continuing evolution. | during the past 20 years, laboratory systems have evolved to a high degree of complexity. in some cases, continuing addition of new features has adversely affected functionality. there is increasing recognition that the number of features listed on a request for proposal does not necessarily provide an accurate guide to functionality in day to day operations. | 2007 | 2040150 |
| cardiomyopathy and woolly haircoat syndrome of hereford cattle. | 1991 | 2043089 | |
| kappa and attenuation of the odds ratio. | this paper explores the relation between reliability and validity for binary variables. an equation is first derived for expressing the kappa coefficient of reliability as a function of true prevalence, sensitivity, specificity, and the degree of correlation of errors within true positives and within true negatives. it is then shown that under certain circumstances kappa is closely related to an index of the validity of the odds ratio as a means for quantifying an association between an imperfec ... | 2007 | 2078611 |
| [derivative spectroscopy and its use in sanitary hygiene control]. | an analytical method is developed for defining the residual quantities of rodenticide "brodifacoum" (talon) used in the control of harmful field rodents and especially for species microtus. the method is based on extracting the pesticide with chloroform and making use of spectrophotometry in the ultraviolet field in intervals 340-240 nm. the second derivative of the absorption is utilized as well as the band with maximum 288 nm and minimum 228 nm. the peak height in this interval is in proportio ... | 2007 | 2099444 |
| [expert assessment of asbestos-induced lung damage]. | asbestos is a mineral of special technical properties and therefore used in many products all over the world. the inhalation of asbestos causes chronic inflammation of lung--the asbestosis--and pleura--pleuraplaques and pleuritis--and is responsible for mesothelioma and lung cancer. under normal conditions the diagnosis asbestosis is easy because of the typical x-ray findings and the history of intensive exposure of asbestos. in rare conditions the history of exposure is uncertain and the diagno ... | 2007 | 2139990 |
| accident compensation: gates and gatekeepers. | 1996 | 2143261 | |
| the evolution of quality of life evaluations in cancer therapy. | patients' feelings, psychological and functional status, and quality of life have often been regarded as unmeasurable subjective entities that cannot be scientifically studied. but now, with better measurement tools, the cancer patient's quality of life can be understood in more operational terms than the "soft" subjective statements that have too often characterized the field to date. this paper addresses the issue of quality of life from several perspectives: 1. historical antecedents of the c ... | 1996 | 2143407 |
| a simple but powerful theory of the moon illusion. | modification of restle's theory (1970) explains the moon illusion and related phenomena on the basis of three principles: (1) the apparent sizes of objects are their perceived visual angles. (2) the apparent size of the moon is determined by the ratio of the angular extent of the moon relative to the extents subtended by objects composing the surrounding context, such as the sky and things on the ground. (3) the visual extents subtended by common objects of a constant physical size decrease syst ... | 2000 | 2144580 |
| vestibular papillae of the vulva. lack of evidence for human papillomavirus etiology. | vestibular papillae of the vulva are usually considered as anatomical variants of the vestibular mucosa. clinically, however, they are quite often interpreted as condylomata acuminata and recent studies have suggested that they could be related to human papillomavirus infection. this prompted us to search for human papillomavirus dna using the southern blot hybridization technique, by analyzing biopsy specimens taken from 29 patients who presented with papillae of the vestibular mucosa. human pa ... | 1990 | 2175164 |
| psychological impact of islet cell-antibody screening. preliminary results. | the identification of at-risk individuals before the onset of insulin-dependent diabetes mellitus with islet cell-antibody (ica) screening programs could have significant psychological sequelae. we initiated a descriptive study of ica+ subjects and their family members in which reactions to study participation, anxiety, and coping responses are monitored. described here are preliminary results from 18 ica+ youngsters, 6 ica+ adults, and their family members. ica+ identification resulted in clini ... | 2007 | 2190772 |
| doppler-guided axillary block in a burn patient. | 2007 | 2203288 | |
| requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. | by analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix. | 1990 | 2234077 |
| [hydatidosis of the cranial vault. two case reports]. | the authors report 2 cases of echinococcosis of the cranial vault, an extremely rare localization of hydatid disease. the parietal bone was involved in one case and the occipital bone in the other. the authors discuss the mechanism and classification of cranial vault echinococcosis. the clinical signs of the disease as well as its radiological appearances and especially its very characteristic ct scan appearances are studied in relation to the literature. | 2007 | 2234264 |
| [pathologico-anatomic findings in spontaneous abortion and induced abortion during the 2nd pregnancy trimester]. | reported in this paper are results obtained from morphological investigations of 200 fetal abortions which had occurred in the fourth to sixth months of pregnancy. they were spontaneous abortions and abortions induced primarily for fetal indications (31 cases). causes are subdivided in this report by placental, fetal, and maternal factors. fetal causes accounted for 18.5% of all cases (most of them fetal malformations, induced abortions included). maternal causes accounted for 7.5%, among them e ... | 2007 | 2238952 |
| [pathologico-anatomic findings in spontaneous abortion and induced abortion during the 2nd pregnancy trimester]. | reported in this paper are results obtained from morphological investigations of 200 fetal abortions which had occurred in the fourth to sixth months of pregnancy. they were spontaneous abortions and abortions induced primarily for fetal indications (31 cases). causes are subdivided in this report by placental, fetal, and maternal factors. fetal causes accounted for 18.5% of all cases (most of them fetal malformations, induced abortions included). maternal causes accounted for 7.5%, among them e ... | 2007 | 2238952 |
| introduction to endoscopic therapy for bleeding peptic ulcers. | 2007 | 2242806 | |
| leiomyosarcoma arising in a lipoleiomyoma. | a leiomyosarcoma arising in a uterine lipoleiomyoma is described in a 70-year-old woman. the tumor measured 11 cm and was located in the corpus uteri. it was composed of a mixture of firm, pale tan, whorled tissue and soft, white or hemorrhagic areas. histologically, the firm tissue was a mixture of bland smooth muscle, fat and fibrous tissue, whereas the soft areas showed a malignant spindle cell tumor with smooth muscle differentiation. pure sarcoma similar to the malignant portion of the lipo ... | 2008 | 2258087 |
| kinetic study of esterification by immobilized lipase in n-hexane. | the kinetic of the esterification of oleic acid by ethanol catalyzed by immobilized lipase of mucor miehei in n-hexane as a solvent has been completely studied. the kinetics of the reaction are suggested to agree with a ping-pong bi bi mechanism in which only inhibition by excess of ethanol has been identified. values of all apparent kinetic parameters were computed. no evidence of any significant external diffusional limitation which could account for these values has been detected. optimizatio ... | 1990 | 2265698 |
| gap junctional permeability is affected by cell volume changes and modulates volume regulation. | isolated pancreatic acinar cell pairs became electrically uncoupled by exposure to a mild hypotonic shock. reduction of bath osmolarity caused a delayed closure of gap junctional channels in the minute range. dialysis of cell pairs by gtp[s] in the double whole-cell patch-clamp mode shortened the latency and shifted the hypotonically induced electrical uncoupling to lower osmolarity changes. cellular treatment with cytochalasin b catalyzed electrical uncoupling by a hypotonic shock. in all cases ... | 2008 | 2265713 |
| studies on the mechanism of oxidative phosphorylation. positive cooperativity in atp synthesis. | kinetic and nucleotide binding studies have shown that submitochondrial particles from bovine heart possess three exchangeable binding sites for adp or gdp. in order of decreasing affinity at neutral ph, these sites will be referred to as sites i, ii, and iii, and their respective dissociation constants as ki, kii, and kiii. in oxidative phosphorylation experiments in the presence of saturating amounts of inorganic phosphate, rapid atp (or gtp) synthesis occurred only upon adp (or gdp) binding t ... | 1990 | 2294123 |
| glucocorticoid stimulation of fatty acid synthesis in explants of human fetal lung. | we examined the effects of glucocorticoids and thyroid hormone (t3) on fatty acid synthesis, fatty acid composition and fatty acid synthetase activity in explants of human fetal lung (16-23 wk gestation). explants were cultured 1-7 days in the absence (control) or presence of dexamethasone (10 nm) and/or t3 (2 nm). in control explants fatty acid synthesis and fatty acid synthetase activity increased 200% and 455%, respectively, between 1 and 5 days. dexamethasone (10 nm) stimulated fatty acid sy ... | 1990 | 2297514 |
| calcitonin gene-related peptide stimulates irregular spiking and transit of contents in the small intestine of the rat. | 1990 | 2327270 | |
| inhibitory effects of neuropeptide y on adenylate cyclase of rabbit ciliary processes. | the inhibitory effect of neuropeptide y (npy) was studied on the adenylate cyclase (ac) activity in homogenates of rabbit ciliary processes and compared with that of the alpha 2-adrenergic agonist clonidine (cln). npy inhibited basal ac activity as well as ac activity stimulated by isoproterenol (iso), vasoactive intestinal polypeptide (vip) or forskolin (fsk). the extent of this inhibition corresponded well to the inhibition elicited by cln. the inhibitory effects of npy and cln appeared to be ... | 1990 | 2335109 |
| [radical surgical intervention with conventional radiation versus multimodality therapy protocol in undifferentiated thyroid cancer]. | out of a total of 550 patients with thyroid cancer diagnosed over the 16-year period 1972-june 1989, 44 showed undifferentiated carcinoma and were treated by thyreoidectomy and early postoperative external irradiation. in order to analyse the outcome in patients treated by primary surgery in contrast to patients treated by means of a multimodal therapy concept we compared our surgical procedures with regard to primary surgical approach, early postoperative course, operative complications and sur ... | 2008 | 2375117 |
| positive and negative symptoms and social competence in adolescents at risk for schizophrenia and affective disorder. | the authors compared adolescents at risk for schizophrenia and affective disorder and normal adolescents. the subjects at risk for schizophrenia had significantly poorer social competence, and formal thought disorder was greater in both high-risk groups. there were no group differences in negative symptoms. | 2008 | 2386257 |
| treatment of behavioral disorders in animals. | 1990 | 2386258 | |
| cooperativity of carbohydrate moiety orientation and beta-turn stability is determined by intramolecular hydrogen bonds in protected glycopeptide models. | the 2,3,4,6-tetra-o-acetyl-beta-d-gluco-, and beta-d-galactopyranosides, as well as approximately 4:1 anomeric mixtures of alpha- and beta-mannopyranosides of boc-x-y-nhch3 dipeptides (x-y = pro-ser, pro-d-ser, val-ser, val-d-ser, and gly-ser) have been synthesized. cd and ir spectroscopic studies were performed to characterize the conformation of the glycosylated peptide backbone and examine the possible formation of intrapeptide and glycopeptide intramolecular h-bonds. it was found that o-glyc ... | 2008 | 2386806 |
| obstetric outcome in homeless women. | to characterise the pregnant homeless population booking and delivering at st mary's hospital, london, and ascertain whether their obstetric outcome was adversely affected by their homeless condition. | 2008 | 2390619 |
| proceedings of the third international symposium on minimal residual disease in acute leukemia. 28-30 march, 1990, rotterdam, the netherlands. | 2008 | 2390635 | |
| [immunohistochemical study and lectin distribution of thyroid carcinoma originated from follicular epithelium]. | 97 cases of thyroid carcinoma originated from follicular epithelium were investigated by using histological and immunohistochemical techniques with special reference to lectin distribution. according to the who histological typing of thyroid tumours, these cases were divided into three categories as follows: papillary carcinoma of thyroid (pct) 56, follicular carcinoma of thyroid (fct) 31 and undifferentiated carcinoma of thyroid (uct) 10. results showed that three different kinds of thyroid car ... | 1990 | 2390796 |
| [combination chemotherapy with cis-diamminedichloroplatinum (cddp) and other anticancer agents for patients with advanced esophageal cancer]. | combination chemotherapy with cis-diamminedichloroplatinum (cddp) and other anticancer agents was performed in patients with advanced esophageal cancer. from july 1982 to september 1984, 16 patients were entered into this study and divided into two regimens. in regimen i, 5 patients were treated with a daily dose of 20 mg cddp and 10 mg peplomycin for five consecutive days and 10 mg mitomycin c on the first day. this course was repeated 2 or 3 times every 4 weeks. as for evaluation, 1 pr (20%) a ... | 2008 | 2408579 |
| simplified differential staining of mouse sister chromatids. | many previously developed methods for sister chromatid exchange (sce) analysis both in vivo and in vitro have been published during the past decade. such methods have met with success in many but not all laboratories. these methods often involve expensive, hazardous equipment such as ultraviolet light and mercury lamps, as well as tedious treatments with hot salt solutions, acids or enzymes. the authors have developed an in vivo method using a 50 mg bromodeoxyuridine (brdu) pellet combined with ... | 1986 | 2427279 |
| a 50-kda fragment from the nh2-terminus of the heavy subunit of clostridium botulinum type a neurotoxin forms channels in lipid vesicles. | 1. a 50-kda fragment representing the nh2-terminus of the heavy subunit of botulinum type a neurotoxin was found, at low ph, to evoke the release of k+ from lipid vesicles loaded with potassium phosphate. similar k+ release was also observed with the intact neurotoxin, its heavy chain and a fragment consisting of the light subunit linked the 50-kda nh2-terminal heavy chain fragment. the light subunit alone, however, was inactive. 2. in addition to k+, the channels formed in lipid bilayers by bot ... | 1987 | 2441987 |
| structural constraints and gene dynamics. | 2008 | 2483277 | |
| regulation of heme biosynthesis in chick embryo liver cells. | according to current evidence heme controls the heme biosynthetic pathway primarily by controlling translocation of inactive pre-ala-s from the cytosol into the mitochondrion, where ala-s is active. a secondary mechanism involves inhibition by heme of transcription of the ala-s gene. porphyrinogenic drugs act by lowering a regulatory "free heme pool" by three different mechanisms: (a) by mechanism-based inactivation of cytochrome p-450 resulting in n-alkylprotoporphyrin formation and ferrochelat ... | 2008 | 2486279 |
| effects of irradiation on diabetes in the bb/wor rat. | lymphoid irradiation is known to prevent spontaneous autoimmune diabetes in susceptible bb rats. the present studies investigated further the effects of radiation in diabetes prone (dp) and resistant (dr) bb/wor rats, and histocompatible yoshida (yos) rats. single doses of total body gamma irradiation (125-600 rads) induced diabetes within 22-44 days in 20 of 102 (20%) 30 day old dr rats, less than 1% of which develop the disease. radiation was also associated with (1) a reduction in the ratio o ... | 1989 | 2491639 |
| [experimental evolutive cycle of diphyllobothrium erinaceieuropei in paracyclops fimbriatus, tadpoles of bufo arenarum and dogs]. | experiments were performed in order to develop the life cycle of diphyllobothrium erinaceieuropei rudolphi 1819 (cestoda, pseudophyllidea) in paracyclops fimbriatus and bufo arenarum as intermediate hosts and dogs as definitive hosts. the eggs of diphyllobothrium erinaceieuropei from faeces of naturally infected dogs were kept refrigered, in water. in order to obtain coracidiums they were incubated at 25 degrees c, and then were placed in a flask which contained paracyclops fimbriatus. the copep ... | 1989 | 2516918 |
| ptca in the elderly: results and expectations. | percutaneous transluminal coronary angioplasty (ptca) is an excellent and safe alternative mode of revascularization in selected elderly (greater than 65 years) patients. the initial success rate at our institution for elective and non-elective procedures is essentially equal when compared with a younger (less than or equal to 65 years) population. although the 24-hour mortality of 1.0% was higher during elective ptca for the elderly versus 0.3% in those 65 and under, this is still very acceptab ... | 2007 | 2525508 |
| use of synthetic ribosome binding site for overproduction of the 5b protein of insertion sequence is5. | insertion sequence is5 is a bacterial transposable element which contains three open reading frames designated 5a, 5b and 5c. although there was no detectable expression from the 5b open reading frame when it was preceded by the native promoter and ribosome binding site or by a tac promoter and the native ribosome binding site, we have overproduced a 5b protein both in vitro and in escherichia coli cells by using a tac promoter and a specially-designed synthetic ribosome binding site. beta-galac ... | 1989 | 2538799 |
| effect of prolonged infusion of anf in normotensive and hypertensive monkeys. | it is now recognized that bolus and short-term infusions of atrial natriuretic factor (anf) into different species lead to a slight and transient decrease of blood pressure, while prolonged infusions cause a significant blood pressure reduction in hypertensive but not in normotensive rats. the present study was designed to evaluate the effects of prolonged anf infusions on blood pressure and humoral parameters in normotensive and hypertensive african green monkeys (cercopithecus aethiops). human ... | 1989 | 2553071 |
| the nature and function of polypeptide growth factor receptors in the human placenta. | 1989 | 2561287 | |
| proton nmr and cd solution conformation determination and opioid receptor binding studies of a dynorphin a(1-17) model peptide. | the opioid peptide dynorphin a(1-17) contains a peptide segment in residues 7-15 with the potential to form an amphiphilic beta-strand. this amphiphilic structure may, like the amphiphilic alpha-helices found in many other peptide hormones, be an important determinant of its interactions with membranes and receptors. in order to investigate and characterize these interactions, we have synthesized a 17-residue dynorphin analogue (yggflkkvkpkvkvkss) that incorporates a peptide model of this amphip ... | 1989 | 2574597 |
| [use of 2 internal mammary arteries in coronary bypass. combination with a bypass using the gastroepiploic artery in 2 cases]. | coronary revascularisation by bilateral internal mammary artery grafting was performed in 39 patients. the left internal mammary was anastomosed to the left anterior descending (n = 22), the left lateral (n = 12) or diagonal artery (n = 5). the right internal mammary was implanted on the right coronary (n = 17), the left anterior descending (n = 16), the left lateral (n = 3) or diagonal artery (n = 3). in two cases, the inferior myocardial segments were revascularised by grafting the gastroepipl ... | 2008 | 2575891 |
| effects of gestational exposure to phencyclidine: distribution and neurochemical alterations in maternal and fetal brain. | phencyclidine is a widely used drug of abuse and is known to produce a wide variety of psychoactive effects. pcp abuse by pregnant women has been reported to result in the birth of infants exhibiting irritability, jitteriness and hyperactivity with high pitched cries. the present study was designed to evaluate the distribution of pcp in the maternal and fetal brain and the neurochemical effects produced by gestational exposure. pregnant sprague-dawley rats were treated sc with 5 mg/kg pcp on 3 c ... | 1989 | 2576301 |
| mental ability, symbolic play and receptive and expressive language of young children with down's syndrome. | the relationship between measures of mental ability, symbolic play and expressive and receptive language was investigated in a sample of 73 children with down's syndrome (mean ca 48.9 months, range 19-90 months; mean ma 30.4 months, range 13-73 months). language delay became increasingly apparent with age, and more so in boys than girls. there was no significant difference between mental ages derived from standard ability tests and corresponding age equivalent scores of the lowe and costello sym ... | 2008 | 2579964 |
| cough associated with canine vaccination? | 1989 | 2588459 | |
| [changes in lymphocytes in acute suppurative-destructive lung diseases]. | a study of the content of lymphocytes and their populations, indices of intracellular viral involvement of the lymphocytes in 32 patients with acute purulent-destructive pulmonary diseases and 46 healthy persons revealed an increase of the percent of non-viable lymphocytes containing viral inclusions. viral involvement of lymphocytes is considered one the leading causes of increased lymphocyte death. | 2008 | 2588523 |
| risk of cancer in pesticide applicators in swedish agriculture. | the risk of cancer was analysed in a cohort of 20,245 licensed pesticide applicators in agriculture who had licences issued between 1965 and 1976. most were men (99%) and about 50% had been born in 1935 or later. the cohort was followed up in the swedish cancer register from date of licence until death or 31 december 1982. the mean follow up time was 12.2 years. average time since first exposure was longer, however, since one fifth of the cohort was exposed in the 1950s. a total of 558 malignant ... | 2007 | 2590647 |