Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| ultrastructural features of the neuromuscular spindle in the dystrophic mouse. | 1979 | 159888 | |
| the fibrinolysin system and its relationship to disease in the newborn. | the fibrinolysin system is incomplete in newborn infants. lack of serum plasminogen in premature newborn has an important role in the pathophysiology of the respiratory distress syndrome since alveolar fibrin deposits cannot be eliminated. urokinase activated human plasmin has increased the survival rate of infants with respiratory distress syndrome. plasminogen given i.v. at birth has reduced the incidence and the severity of respiratory distress syndrome, in a randomized double-blind study of ... | 1979 | 161694 |
| neovasculogenesis. triggering factors and possible mechanisms. | the possible regulating mechanism(s) of neovascularization are discussed. experimental data supporting the view that ocular neovascularization might be triggered by a fundamental metabolic mechanism are presented. based on his own data and scattered evidence from the literature, the author suggests a model for a possible regulating mechanism of the neovascular process in which the prostaglandins fulfill the role of neovascular mediating substances. preliminary results demonstrating that indometh ... | 1979 | 94468 |
| synthetic antigens iii. antigen-binding cells to interpolymer of styrene and maleic acid psm and sheep red blood cells in mice immunized with psm. | studies on the immune response in mice to a new synthetic antigen interpolymer of styrene and maleic acid (psm) are described. the immune response was measured by determination of antigen binding cells by means of rosette test with psm-coated srbc, an unexpected effect was observed--besides rosette-forming cells for psm, rosette-forming cells and agglutinating antibodies for sheep red cells were found. the results presented in this paper suggest that psm is acting both as an immunogen and a poly ... | 1979 | 94989 |
| isolation of an influenza virus subtype hav4navl from a budgerigar. | 1979 | 108521 | |
| thyroid function in preterm infants with respiratory distress syndrome. | thyroid function was evaluated in premature infants 30 to 35 weeks ega with severe rds and was compared to that of healthy control subjects of similar ega. the infants with rds had significantly lower serum levels of t3, t4, and ft4i during the first 60, 90, and 30 days, respectively, and had elevated t3ur during the first 10 days. the mean (+/- sd) postdelivery tsh peak was lower in the rds group (32.8 +/- 9.6 muu/ml) than in the control group (60.9 +/- 21.8 muu/ml; p less than 0.005). after tr ... | 1979 | 107304 |
| secretory granules of the duodenal enterochromaffin cells of the cat. | 1979 | 222959 | |
| endophthalmitis associated with haemophilus influenzae type b bacteremia and meningitis. | the unusual occurrence of endophthalmitis associated with haemophilus influenzae type b bacteremia and meningitis was confirmed in three young children during a five-year period. in contrast to bacterial endophthalmitis attributed to other microorganisms, these three infections resolved completely within a few days with conventional antimicrobial therapy. endophthalmitis is but one of the apparently increasing number of unsuual complications that may be observed as a result of h influenzae type ... | 1979 | 312601 |
| lung compliance and lung morphology following artificial ventilation in the premature and full-term rabbit neonate. | rabbit neonates delivered on day 27--30 of gestation were subjected to intermittent positive pressure ventilation (ippv) for 60 min. tidal volume was standardized to 10 ml/kg, and the insufflation pressure required to maintain this tidal volume was recorded. the quasistatic compliance of the lung-thorax system, corrected for variations in body weight, was significantly lower in animals delivered on day 27--28 than in those delivered on day 29--30. immature animals with low lung-thorax complianc ... | 1979 | 394314 |
| effects of fildes enrichment on antibiotic susceptibility testing of haemophilus influenzae in the autobac. | the results of this investigation showed that the autobac could be used to determine the susceptibility of haemophilus influenzae to ampicillin, chloramphenicol, and tetracycline when eugonic broth was supplemented with 1.5% fildes enrichment. an excellent correlation was obtained between the susceptibilities as determined by the agar dilution minimal inhibitory concentration method and the autobac. for ampicillin all h. influenzae isolates with minimal inhibitory concentrations of </=1 mug/ml h ... | 1979 | 314272 |
| single-fiber epsps in amphibian motoneurons. | 1983 | 217481 | |
| chloramphenicol in developing countries. | 1985 | 2865547 | |
| [clinical characteristics the ent complications of patients with type a (h3n2) influenza during the influenza epidemic in leningrad]. | 1985 | 2951903 | |
| effects of tunicamycin on ngf binding and neurite outgrowth in pc12 cells. | the effects of inhibition of glycosylation on nerve growth factor (ngf) binding and neurite outgrowth response of pc12 cells have been examined. exposure to tunicamycin (1-10 micrograms/ml) for 24-36 hr eliminates the rapidly dissociating component of ngf binding and decreases the proportion of pc12 cells capable of elaborating neurites in a dose-dependent manner. these decreased cellular responses are probably due to an underglycosylation of the ngf receptor, since the effects of tunicamycin ar ... | 1985 | 2991546 |
| effect of the growth of anaerobic bacteria on the surface ph of solid media. | changes in surface ph occurring after varying periods of anaerobic incubation were measured for a total of 23 test solid media. there was little change in the surface ph of uninoculated plates, but plates inoculated with bacteriodes fragilis showed a striking fall in ph, to ph 5 in the case of some of the test media. the problems of controlling the surface ph of solid media are discussed and possible methods of control are considered. | 1985 | 2860132 |
| [production of tetanolysin preparations and characteristics of their properties]. | as the result of the study of tetanolysin-producing clostridium tetani strains, their populations have been found to be markedly heterogeneous with respect to the hemolytic activity of clone cultures. on the basis of normal and dialyzed cultures of selected variants with maximum activity the preparations of tetanolysin have been obtained, and their hemolytic activity and antigenic properties have been studied. antihemolytic rabbit sera have also been obtained and characterized. partially purifie ... | 1985 | 3898671 |
| [production of tetanolysin preparations and characteristics of their properties]. | as the result of the study of tetanolysin-producing clostridium tetani strains, their populations have been found to be markedly heterogeneous with respect to the hemolytic activity of clone cultures. on the basis of normal and dialyzed cultures of selected variants with maximum activity the preparations of tetanolysin have been obtained, and their hemolytic activity and antigenic properties have been studied. antihemolytic rabbit sera have also been obtained and characterized. partially purifie ... | 1985 | 3898671 |
| structure of the linkage units between ribitol teichoic acids and peptidoglycan. | the structure of the linkage regions between ribitol teichoic acids and peptidoglycan in the cell walls of staphylococcus aureus h and 209p and bacillus subtilis w23 and ahu 1390 was studied. teichoic acid-linked saccharide preparations obtained from the cell walls by heating at ph 2.5 contained mannosamine and glycerol in small amounts. on mild alkali treatment, each teichoic acid-linked saccharide preparation was split into a disaccharide identified as n-acetylmannosaminyl beta(1----4)n-acetyl ... | 1985 | 3918002 |
| consequences of the o2-co2 dissociation curves for gas exchange in avian and mammalian lung at various altitudes. | gas exchange in avian and mammalian lung was studied with computer simulations using mutually dependent o2-co2 dissociation curves. the mammalian lung was simulated with an ideal mixing unit. the model of the avian lung consisted of 25 ideal mixing units placed in series with respect to the ventilation but placed in parallel with respect to the perfusion (cross-current arrangement). the consequence of the right shift in the avian oxygen dissociation curve, if compared with the human dissociation ... | 1985 | 3938606 |
| improved localization of intracellular sites of phosphatases using cerium and cell permeabilization. | a simple permeabilization method has been developed that allows for intracellular localization of acid phosphatase in neutrophils and several types of tissue culture cells with cerium. this permeabilization procedure also facilitates intracellular alkaline phosphatase localization in neutrophils without the loss of cell surface reaction in this cell type. only the cell surface reaction was detected in the absence of permeabilization. glutaraldehyde-fixed cells were permeabilized with detergent d ... | 1985 | 2991362 |
| cloning and characterization of mefloquine-resistant plasmodium falciparum from thailand. | resistance to mefloquine in plasmodium falciparum has begun to occur along the border of thailand and kampuchea. as a means of assessing the natural occurrence of mefloquine resistance, the admission and post-treatment parasite isolates from a mefloquine treatment failure were cloned and characterized. clones from the admission isolate were susceptible to mefloquine in vitro (id50 of 3.4 [2-5], g [95% ci] ng/ml) and showed a mixture of isozyme types for glucose phosphate isomerase (gpi types i a ... | 1985 | 3914841 |
| [changes in the mucous membrane of the trachea and bronchi in dogs based on bronchoscopic data for the combined action of 239pu and gamma-radiation as compared with the individual actions]. | it was established that under conditions of combined exposure of dogs to external gamma- and internal alpha-radiation, a preirradiation with 51.6 mc/kg gamma-rays prevents the development of the signs of endobronchitis which are typical for endobronchitis induced by inhalation of submicron 239pu dioxide and manifested by hyperemia of trachea and bronchus mucosa, edema, and the presence of mucopurulent exudate. | 1985 | 3909215 |
| [principles of organization of tissue mosaics of simple squamous epithelia]. | with the aim to study general principles on organization of tissue mosaics of various types of simple squamous epithelii, a quantitative topological analysis has been performed in the frog mesothelial mosaics, in the posterior epithelium of the rabbit cornea and in the rat aortal endothelium after lewis method. to all the types of simple squamous epithelii studied the histological law of lewis can be applied. as demonstrates the qualitative analysis of the mosaics, the mesothelium and the poster ... | 1985 | 3994528 |
| [in vivo experimental modelling of the infectious process caused by stable l forms of the causative agent of typhoid]. | to simulate the infectious process and to study the persistence of l-forms, rabbits and guinea pigs were infected with s. typhi stable l-forms. the materials presented in this work indicate that both subconjunctival and intraperitoneal infection led to the development of the clinically indistinct, but morphologically pronounced pathological process with characteristic localization and typical changes in the gastrointestinal tract. the typical features of the process were the generalized immunomo ... | 1985 | 4060947 |
| [modifications in relation to age in the number and diameter of nerve fibers in dorsal spinal roots of the rat]. | 1985 | 4062475 | |
| pancreatic stone protein. i. evidence that it is encoded by a pancreatic messenger ribonucleic acid. | we have previously shown that the pancreatic stone protein (psp) is an inhibitor of calcium carbonate crystal growth and may participate in the stabilization of the normally supersaturated pancreatic juice. our aim in this study was to determine if psp is a normal secretory product of the human pancreas by determining if the normal human pancreas contains a messenger rna coding for psp. human pancreatic messenger rnas were used to direct protein synthesis in a cell-free translation system. immun ... | 1985 | 4007427 |
| necrotizing soft-tissue infections caused by marine vibrios. | halophilic, noncholera marine vibrio bacteria can cause septicemia, gastroenteritis, cellulitis, and necrotizing fasciitis. we describe six patients with necrotizing fasciitis and review 12 cases described previously. the 18 patients included 14 men and four women. their ages ranged from 32 to 79 years (average 58.1 years). eleven patients were older than 55 years. nine infections were caused by v. vulnificus, three by v. parahaemolyticus, and one by v. alginolyticus. in five cases the vibrio sp ... | 1985 | 4012603 |
| osteocalcin in human serum: a circadian rhythm. | osteocalcin, the vitamin k-dependent protein synthesized in bone, is found in blood. the level of circulating osteocalcin has recently been used as an indicator of the rate of bone turnover. we measured serum osteocalcin during 24-h periods in 6 normal 20- to 30-yr-old men and 4 women. blood was sampled via an indwelling venous catheter every 30 or 60 min for 24 h. circadian rhythmicity in circulating osteocalcin was found in 9 of the 10 individuals studied. osteocalcin levels fell during the mo ... | 1985 | 3871789 |
| a rapid method for culturing guinea pig gastric mucous cell monolayers. | a method has been developed for growing confluent primary cultured monolayers of guinea pig gastric mucous cells suitable for in vitro electrophysiological, transport, and pharmacological studies. isolated mucous cells were enriched on a one-step percoll density gradient and plated on fibronectin-coated plastic dishes or in small cups with holes containing glutaraldehyde-fixed vitrogen gels. these cups were designed to fit in ussing chambers. mucous cells attached, proliferated, and formed confl ... | 1985 | 4030627 |
| response of dogs to challenge with ancylostoma ceylanicum during the tenure of a primary hookworm infection. | a model of human hookworm infection has been developed which shows that dogs currently infected with small numbers of hookworms are considerably resistant to a challenge infection with a large inoculum of infective larvae. two groups of dogs were infected with 500 larvae and four weeks after infection one group together with a previously uninfected control group were infected with 5,000 larvae and followed for six weeks. when compared with the secondary infection control dogs, faecal egg excreti ... | 1986 | 3798534 |
| [atracurium (tracrium). a new non-depolarizing neuromuscular blocker]. | 1986 | 3755261 | |
| a model for the ca2+-induced conformational transition of troponin c. a trigger for muscle contraction. | the initial contractile event in muscle is the binding of ca2+ ions to troponin c of the troponin complex, leading to a series of conformational changes in the members of the thin and thick filaments. knowledge of the crystal structure of turkey skeletal muscle troponin c has provided a structural basis for the modeling of the first stage of this process in atomic detail. this crystal structure probably represents the molecule in the relaxed state of muscle, with two of the maximum of 4 ca2+ ion ... | 1986 | 3949740 |
| oligodeoxynucleotide stability in subcellular extracts and culture media. | oligodeoxynucleotide degradation was studied in four systems in order to assess the importance of degradation in hybridization arrest experiments dependent on oligodeoxynucleotides complementary to mrna sequences. oligodeoxynucleotides were not detectably degraded over 2 h at 37 degrees c in rabbit reticulocyte lysate or dulbecco's modified essential medium with 5% fetal calf serum, but were degraded over 2 h in hela cell postmitochondrial cytoplasmic extract, and were degraded within 15 min in ... | 1986 | 3772027 |
| [evoked spinal potentials in the wistar rat: effect of cord compression and drugs]. | changes of the evoked spinal cord potential (esp) were measured in wistar rats by giving acute compression to the spinal cord injury. the effects of naloxone, methylprednisolone and prostaglandin e1 on esp of the damaged spinal cord were also closely examined. normal esp of rats showed two negative peaks, an initial wave (the 1st potential) and a subsequent gentle and small wave (the 2nd potential). after placing a 10 g weight on the spinal cord, the potential decreased in amplitude and prolonge ... | 1986 | 3772215 |
| effects of testosterone, estrogen, and dihydrotestosterone upon aggressive and sexual behavior of female rats. | groups of female tmd rats were treated either with estradiol benzoate (eb), dihydrotestosterone propionate (dhtp), testosterone propionate (tp), eb + dhtp (eb/dhtp), or with oil. these groups of females were tested for social aggression and for masculine and feminine sexual behavior. in addition, patterns of masculine and feminine sexual responses during the aggressive encounters, were investigated. tp-treated females of the same strain were used as opponents in the tests for aggression. in acco ... | 1986 | 3793023 |
| a theoretical model to study the effect of convection and leaky junctions on macromolecule transport in artery walls. | a mathematical model is presented herein to determine the effect of convection on macromolecular transport across an artery wall due to transmural or osmotic pressure differences. the model is based on an extension of the leaky junction-cell turnover model of weinbaum et al. (1985) to take into account a combined transport mechanism of convection and diffusion and also to provide the leaky junctions in the model with a finite resistance, thus allowing the results to be extended to intercellular ... | 1986 | 3795993 |
| high oxygen requirements of dyskinetic cardiac muscle. | this study assesses the regional oxygen requirements of muscle segments that are beating and working, beating and empty, arrested and decompressed, and nonischemic that move dyskinetically. regional oxygen demands were evaluated by producing a dyskinetic segment by infusing regional cardioplegic solution through a left anterior descending coronary artery catheter with and without extracorporeal circulation. the results show that the o2 demands of the perfused dyskinetic cardiac muscle segment (4 ... | 1986 | 3747582 |
| a model for the ca2+-induced conformational transition of troponin c. a trigger for muscle contraction. | the initial contractile event in muscle is the binding of ca2+ ions to troponin c of the troponin complex, leading to a series of conformational changes in the members of the thin and thick filaments. knowledge of the crystal structure of turkey skeletal muscle troponin c has provided a structural basis for the modeling of the first stage of this process in atomic detail. this crystal structure probably represents the molecule in the relaxed state of muscle, with two of the maximum of 4 ca2+ ion ... | 1986 | 3949740 |
| lymphocyte response to klebsiella in ankylosing spondylitis. | the lymphocyte response of mononuclear cells (mnc) to klebsiella (klebs) was studied in ankylosing spondylitis (asp) and, for comparison, in patients convalescing from klebs infection and in hla-b27+ and b27- healthy blood donors. when large doses of various klebs cell envelope structures were used, mnc from all healthy blood donors were stimulated to produce lif but not to synthesize significant amounts of dna. in contrast, mnc from convalescent patients showed lif synthesis (but no significant ... | 1986 | 3100299 |
| membrane lipid composition of obligately and facultatively alkalophilic strains of bacillus spp. | the membrane lipids from two obligately and two facultatively alkalophilic strains of bacillus spp. were characterized in a comparative study that included b. subtilis. preparations of membrane lipids were made from ph 10.5-grown cells of all of the alkalophiles and from ph 7.5- or 7.0-grown cells of the two facultative strains and b. subtilis. the two obligate alkalophiles contained high ratios of membrane lipid to membrane protein, and the lipid fraction contained a high proportion of neutral ... | 1986 | 3093462 |
| prostaglandins, thromboxane and leukotriene in human follicular fluid. | the concentrations of prostaglandin e2 (pge2), prostaglandin f2 alpha (pgf2 alpha), thromboxane b2 (txb2) and leukotriene b4 (ltb4) were measured in the follicular fluid of 15 hyperstimulated human follicles. all the samples contained these eicosanoids. ova were recovered in six aspirates; the measured levels of prostanoids and ltb4 did not differ significantly from the levels of nine aspirates without ova. the presence of ltb4 in human follicular fluid suggests that the products of the lipoxyge ... | 1986 | 3022906 |
| ampicillin resistant gonorrhoea in hong kong. | 1986 | 3102346 | |
| [cloning of genes for proline biosynthesis in escherichia coli]. | restriction map of escherichia coli chromosome fragment (7.4 md) carrying proab genes was constructed. localization of proa and prob genes on the cloned chromosome fragment was determined by complementation test and the measuring of glutamylkinase activity (prob gene product). proa and prob genes were cloned separately on multicopy plasmids of alternative orientation and their expression being, probably, under the control of their own regulatory regions, studied. | 1986 | 3026898 |
| [cloning of genes for proline biosynthesis in escherichia coli]. | restriction map of escherichia coli chromosome fragment (7.4 md) carrying proab genes was constructed. localization of proa and prob genes on the cloned chromosome fragment was determined by complementation test and the measuring of glutamylkinase activity (prob gene product). proa and prob genes were cloned separately on multicopy plasmids of alternative orientation and their expression being, probably, under the control of their own regulatory regions, studied. | 1986 | 3026898 |
| surveillance of enterovirus circulation in children communities. | in three children communities covered by a virological study enteroviruses could be isolated from 19.3% of the stool samples, 52.3% of the sewage samples and 9.7% of the samples taken from different objects and surfaces. the isolates belonged to 14 enterovirus serotypes, coxsackie viruses being predominant. there was a good concordance between the serotypes of enteroviruses shed in the stools and those isolated from the environment. the high epidemiological potential of enteroviruses calls for a ... | 1986 | 3008412 |
| involvement of penicillin-binding protein 2 with other penicillin-binding proteins in lysis of escherichia coli by some beta-lactam antibiotics alone and in synergistic lytic effect of amdinocillin (mecillinam). | compared with cefotaxime, ceftazidime, moxalactam, and aztreonam, ceftriaxone produced the best lytic and bactericidal effects when each was added at about 10 times the mic to escherichia coli w7. when each of these antibiotics was added at its mic, only bacteriostasis occurred, but the simultaneous addition of amdinocillin (mecillinam) was synergistic in causing rapid lysis and bactericidal effects. induction of lysis of two e. coli mutants containing either a thermosensitive penicillin-binding ... | 1986 | 3545069 |
| inflammatory fibroid polyp of the stomach. | fourteen cases of inflammatory fibroid polyp of the stomach were studied in terms of immunohistochemistry and ultrastructure. they occurred as polypoid lesions in the antrum, except for two found in the body of the stomach. out of the 14 cases, two were found to be multiple and the remainder solitary. in all but one lesion, the mucosal layer was involved and six lesions were entirely localized within the mucosal layer, suggesting that inflammatory fibroid polyps of the stomach originate in the m ... | 1986 | 3716789 |
| lithium and the neonate: developmental and metabolic aspects. | the interrelationship between lithium salts, which has been used in clinical trials of alcoholism, and ethanol, which evoke fetal alcohol syndrome by chronic use, was studied. this was made by evaluating the effect of prenatal and postnatal exposure to licl on ethanol and acetaldehyde metabolizing enzymes in the newborn mouse. the three li-treatment regimens made consisted of acute and short-term prenatal exposure to licl in addition to postnatal exposure until weaning of the neonates. the weane ... | 1986 | 2941034 |
| toxic effects of cyclosporine on the endocrine pancreas of wistar rats. | the widely used immunosuppressive drug cyclosporine exerts toxic effects on various parenchymal organs including the liver and kidney. this study was performed with the aim of testing whether cyclosporine also affects the endocrine pancreas. daily cyclosporine doses of 50 mg/kg body weight over 3 weeks in rats enhanced the serum bilirubin and creatinine concentrations, led to light-microscopic destruction in the liver and kidneys, and resulted in the development of an impaired glucose tolerance- ... | 1986 | 3510493 |
| gastric dilation in bloodhounds. | 1986 | 3962133 | |
| evidence against systolic intramural forces as the primary cause of subendocardial preponderance of ischemia. | verification of the current view that subendocardial preponderance of ischemia is due to greater forces generated in the deep myocardial layer during systole was undertaken. in anesthetized mongrel dogs transient ischemia was produced in two different situations of altered systolic forces. first, in order to remove that part of the systolic force which is related to intracavitary pressure, left ventricular bypass was created and the left ventricle vented. second, in order to even out the transmu ... | 1986 | 3753389 |
| potential radiopharmaceuticals for the detection of ocular melanoma. part ii. iodoquinoline derivatives and 67ga-citrate. | the uptake and distribution of several 4-(substituted amino)-iodoquinolines, 131i-labelled, and of 67ga-citrate were investigated in syrian golden hamsters with greene melanomas. because of its uptake in the melanoma (tumour/eye ratio 8.9), 4-(dimethylamino-ethylamino)-7-iodoquinoline (nm113) was selected for further investigations as a possible radiopharmaceutical for ocular scintigraphy when labelled with 123i. high uptake of nm113 turned out to be incidental and could not be favourably influe ... | 1986 | 3460807 |
| the ability of single sex infections of schistosoma japonicum to induce resistance to reinfection in mice. | in four experiments, mice harbouring an average 50, 76 or over 200 schistosoma japonicum female worms were not resistant when challenged six to eight weeks after infection. the female worms from these single sex infections were stunted and immature (average length 4.6 mm) and induced no overt pathology in the host. male worm burdens of 60, 135 or 140 also induced little or no resistance to challenge in the host. the males from these single sex infections were fully grown for their age (average l ... | 1986 | 3091678 |
| court decisions streamline appeals process. | 1986 | 3527937 | |
| zinc absorption in inflammatory bowel disease. | zinc absorption was measured in 29 patients with inflammatory bowel disease and a wide spectrum of disease activity to determine its relationship to disease activity, general nutritional state, and zinc status. patients with severe disease requiring either supplementary oral or parenteral nutrition were excluded. the mean 65zncl2 absorption, in the patients, determined using a 65zn and 51cr stool-counting test, 45 +/- 17% (sd), was significantly lower than the values, 54 +/- 16%, in 30 healthy c ... | 1986 | 2873002 |
| enzymes of catecholamine metabolism in the brains of rat strains differing in their preference for or tolerance of ethanol. | the activities of the catecholamine-synthesizing and inactivating enzymes were determined in whole brains of two pairs of rat strains differing in their genetically-determined behavioural responses to ethanol. the alcohol-tolerant (at) rats did not show any significant differences in enzyme activities when compared with the non-tolerant (ant) strain. the activity of tyrosine hydroxylase was found to be significantly higher in brains of the alcohol-preferring (aa) rats, than in those of the alcoh ... | 1986 | 2874817 |
| ontogenetic development of pancreatic thyrotropin-releasing hormone in human foetuses and in infants. | the ontogeny of thyrotropin-releasing hormone (trh) in pancreata of human foetuses from 15-36 weeks of gestation and of infants has been studied. trh was detectable in the pancreas of a 15 week old foetus; a progressive increase of pancreatic trh content was observed until the 34th week of gestation, whereas a progressive decrease was found in the late period of pregnancy and in 1 year old infants. in contrast, the pancreatic insulin content showed a progressive increase during the entire pregna ... | 1986 | 3092527 |
| simplified differential staining of mouse sister chromatids. | many previously developed methods for sister chromatid exchange (sce) analysis both in vivo and in vitro have been published during the past decade. such methods have met with success in many but not all laboratories. these methods often involve expensive, hazardous equipment such as ultraviolet light and mercury lamps, as well as tedious treatments with hot salt solutions, acids or enzymes. the authors have developed an in vivo method using a 50 mg bromodeoxyuridine (brdu) pellet combined with ... | 1986 | 2427279 |
| [genetic counseling in defect abnormalities of the extremities (proceedings)]. | 1986 | 212892 | |
| [treatment of african vesico-vaginal fistulae in a rural hospital (author's transl)]. | the author reports his own experience of this difficult surgery in a rural african hospital. he describes various types of fistulae and 3 technics which gave him 10 recoveries in 19 patients. complications, rules of treatment and nursing are considered. | 1986 | 214663 |
| hepatocarcinogens in nigerian foodstuffs. | 1987 | 211740 | |
| a 50-kda fragment from the nh2-terminus of the heavy subunit of clostridium botulinum type a neurotoxin forms channels in lipid vesicles. | 1. a 50-kda fragment representing the nh2-terminus of the heavy subunit of botulinum type a neurotoxin was found, at low ph, to evoke the release of k+ from lipid vesicles loaded with potassium phosphate. similar k+ release was also observed with the intact neurotoxin, its heavy chain and a fragment consisting of the light subunit linked the 50-kda nh2-terminal heavy chain fragment. the light subunit alone, however, was inactive. 2. in addition to k+, the channels formed in lipid bilayers by bot ... | 1987 | 2441987 |
| onset of steroidogenesis and differentiation of functional lh receptors in rat fetal testicular cultures. | the present study was performed to investigate in vitro the onset of steroidogenesis and the responsiveness to lh in rat fetal testes. the male gonads explanted on days 12.5, 13.5, and 14.5 of gestation in m199 produced testosterone from 15.5 days as is the case in vivo dcamp (1 mm) induced an anticipated steroidogenesis on day 14.5 with secretions of testosterone (0.026 +/- 0.003 ng/gonad/24 h) and progesterone (0.078 +/- 0.005 ng/gonad/24 h), whereas lh (100 ng/ml) has no effect. antiandrogens ... | 1987 | 2823733 |
| spontaneous oscillation of the systemic arterial pressure during cardiopulmonary bypass in man. the effects of some drugs used during the operation. | despite the fact that the blood flow maintained during cardiopulmonary bypass is rather steady in the extracorporeal pump output, the arterial pressure under high-dose fentanyl anaesthesia quite often shows sinusoidal oscillations. in the present study the duration of an oscillatory cycle was on average 17.6 +/- 3.6 s, its amplitude 7.3 +/- 1.6 mm hg and mean systemic arterial pressure 75 +/- 12 mm hg. the oscillation is affected by the drugs used under bypass conditions. in our series of clinic ... | 1987 | 2886117 |
| establishment of a human t-cell hybridoma that produces human macrophage activating factor for superoxide production and translation of messenger rna of the factor in xenopus laevis oocyte. | human monoblast-like histiocytic lymphoma cell line u937 was induced by a macrophage activating factor for o2- production (maf-o) to produce o2- in response to phorbol myristate acetate stimulation. a maf-o-producing human t-cell hybridoma, f4-29-4, was established which was also found to produce macrophage activating factor for glucose consumption (maf-g) and colony stimulating factor (csf) when assayed against mouse bone marrow cells. maf-o could be successfully separated from csf but not from ... | 1987 | 3039355 |
| establishment of a human t-cell hybridoma that produces human macrophage activating factor for superoxide production and translation of messenger rna of the factor in xenopus laevis oocyte. | human monoblast-like histiocytic lymphoma cell line u937 was induced by a macrophage activating factor for o2- production (maf-o) to produce o2- in response to phorbol myristate acetate stimulation. a maf-o-producing human t-cell hybridoma, f4-29-4, was established which was also found to produce macrophage activating factor for glucose consumption (maf-g) and colony stimulating factor (csf) when assayed against mouse bone marrow cells. maf-o could be successfully separated from csf but not from ... | 1987 | 3039355 |
| a clinical trial using a regimen which includes a norgestomet implant and norgestomet plus oestradiol valerate injection as a treatment for anoestrus in dairy cows. | in seasonally calving dairy herds in the macalister irrigation area of gippsland, victoria, cows that had not been observed in oestrus by the start of the mating season and which had inactive ovaries based on rectal palpation and progesterone assay were treated with a hormonal treatment (n = 49). mature cows had calved at least 40 days previously and 2-year-olds had been calved at least 60 days. the treatment consisted of a norgestomet implant and a norgestomet and oestradiol injection on day 1; ... | 1987 | 2820369 |
| the effects of dietary fish oil on hepatic high density and low density lipoprotein receptor activities in the rat. | rats were fed either a standard ration diet or that diet supplemented with 8% by wt of a marine fish oil or safflower oil. after 10 days, plasma triacylglycerols, total cholesterol, high density lipoprotein (hdl) cholesterol, hepatic cholesterol and fatty acid synthesis and hepatic low density lipoprotein (ldl) receptor activity were significantly depressed while hdl receptor activity was significantly increased in rats fed fish oil. fish oil-induced effects on cholesterol metabolism in the rat ... | 1987 | 2820793 |
| the effects of dietary fish oil on hepatic high density and low density lipoprotein receptor activities in the rat. | rats were fed either a standard ration diet or that diet supplemented with 8% by wt of a marine fish oil or safflower oil. after 10 days, plasma triacylglycerols, total cholesterol, high density lipoprotein (hdl) cholesterol, hepatic cholesterol and fatty acid synthesis and hepatic low density lipoprotein (ldl) receptor activity were significantly depressed while hdl receptor activity was significantly increased in rats fed fish oil. fish oil-induced effects on cholesterol metabolism in the rat ... | 1987 | 2820793 |
| methylergometrine antagonizes 5 ht in the temporal artery. | methylergometrine, the main metabolite of methysergide, has 40-times greater 5 ht antagonistic potency than methysergide in isolated segments of human temporal artery. it is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be compared in prophylactic trials in migraine. | 1987 | 3691600 |
| effect of altrenogest and lutalyse on parturition control, plasma progesterone, unconjugated estrogen and 13,14-dihydro-15-keto-prostaglandin f2 alpha in sows. | to investigate control of parturition time, 154 sows farrowing 220 litters at three locations were treated with altrenogest and lutalyse (pg). the four treatment groups were: 1) no treatment (control group); 2) an im injection of 15 mg of pg at 1000 on d 111, 112 or 113 of gestation (d 0 = first day of estrus and gestation); 3) altrenogest (20 mg x sow-1 x d-1) fed twice daily for 4 d starting on d 109, 110 or 111; and 4) altrenogest and an injection of pg at 1000 on the day after the last feedi ... | 1987 | 3610870 |
| human gastrin (gas) rflp recognised by digestion with bamhi or ecori. | 1987 | 2889191 | |
| somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase. | pharmacological characterization of somatostatin (srif) receptors located on somatotrophs, thyrotrophs, and lactotrophs was attempted by measuring the effects of 14 structural agonists of somatostatin (srif) on the inhibition of basal and grf-stimulated gh and basal and trh-stimulated prl and tsh secretion. we also checked the abilities of the analogs to displace [125i]n-tyr-srif binding to pituitary cell membranes and their potency to inhibit adenylate cyclase activity. there was a very good co ... | 1987 | 2890515 |
| serine incorporation into the selenocysteine moiety of glutathione peroxidase. | the selenium in mammalian glutathione peroxidase is present as a selenocysteine ([se]cys) moiety incorporated into the peptide backbone 41-47 residues from the n-terminal end. to study the origin of the skeleton of the [se]cys moiety, we perfused isolated rat liver with 14c- or 3h-labeled amino acids for 4 h, purified the gsh peroxidase, derivatized the [se]cys in gsh peroxidase to carboxymethylselenocysteine ([se]cys(cm)), and determined the amino acid specific activity. perfusion with [14c]cys ... | 1987 | 2948953 |
| structural and metabolic correlates of cell injury in the hypertrophied myocardium during valve replacement. | to characterize the ultrastructural and metabolic changes occurring in the hypertrophied ventricle during cardiac operations in man, we studied 36 patients with valvular heart disease undergoing valve replacement, during which multiple doses of cold potassium cardioplegic solution were administered (group i). each patient had substantial ventricular hypertrophy according to measurements made of left ventricular mass, with a mean of 232.1 +/- 19.8 gm/m2 (normal: 92 +/- 16 gm/m2). serial biopsy sp ... | 1987 | 2952840 |
| bioavailability of phosphorus from defluorinated and dicalcium phosphates and phosphorus requirement of calves. | bioavailability of p from defluorinated phosphate and dicalcium phosphate and the p requirement were studied with 63 male holstein calves. a p depletion diet containing .08% total p on a dry matter basis was fed to all animals for 4 wk beginning at 6 wk of age and 61 kg weight. calves developed typical signs of p deficiency. the depletion period was followed by a 6-wk experimental period in which the same depletion diet was used as a control. phosphorus from each of the two sources was added to ... | 1987 | 3668046 |
| evaluation of the 11co2 positron emission tomographic method for measuring brain ph. i. ph changes measured in states of altered pco2. | the 11co2 method for measuring local brain ph with positron emission tomography (pet) has been experimentally evaluated, testing the adequacy of the kinetic model and the ability of the method to measure changes in brain ph. plasma and tissue time/activity curves measured during and following continuous inhalation of 11co2 were fit with a kinetic model that includes effects of tissue ph, blood flow, and fixation of co2 into compounds other than dissolved gas and bicarbonate ions. for each of ten ... | 1987 | 3121647 |
| reflex changes in sympathetic nerve activity during mechanical ventilation with peep in sino-aortic denervated rats. | the aim of this study was to evaluate the role of cardiopulmonary receptors with vagal afferents in the reflex control of sympathetic nerve activity during mechanical ventilation with positive end-expiratory pressure (peep). experiments were performed on 17 chloralose-anaesthetized rats. changes in renal sympathetic nerve activity (rsna), heart rate and mean arterial pressure were studied at zero end-expiratory pressure (zeep) and at 5 and 10 cm h2o peep in intact animals (n = 8), after sino-aor ... | 1987 | 3296660 |
| topical minoxidil in early androgenetic alopecia. | a randomized, double-blind trial was conducted to determine the relative efficacy and safety of topical minoxidil solution for progressive male pattern baldness. one hundred fifty men with a discernible vertex balding spot were randomly assigned to treatment with either 2% topical minoxidil, 3% topical minoxidil, or placebo. after 4 months, patients receiving placebo were crossed over to 3% minoxidil. the study was concluded after 12 months of treatment, at which time 100 subjects were evaluable ... | 1987 | 3549807 |
| fifteen-year experience with bloodstream isolates of coagulase-negative staphylococci in neonatal intensive care. | investigators worldwide, as well as the neonatologists and infection control team at our hospital, have reported that the incidence of coagulase-negative staphylococcal bacteremia in critically ill neonates has increased dramatically in recent years. to investigate these claims, we examined the results of all blood cultures obtained from 1970 to 1984 in our neonatal intensive care unit. throughout this study period, coagulase-negative staphylococci were prominent blood culture isolates (crude ov ... | 1988 | 3366867 |
| anticonvulsant therapy in small animals. | this article includes an overview of the pathophysiology of seizures and a discussion of the mechanism of action of anticonvulsants based on the targeted physiologic processes. the commonly used anticonvulsants are classified and reviewed by chemical group. the concept, indications, and benefits of therapeutic monitoring of serum anticonvulsant concentrations are presented. the use of anticonvulsant agents for treatment of status epilepticus is addressed. | 1988 | 3064391 |
| [elevated biliary excretion of t4--however, not of t3--in rats with nonthyroidal diseases (nti)]. | 1988 | 3176822 | |
| structural organization of the multienzyme complex of mammalian aminoacyl-trna synthetases. | the multienzyme complexes of mammalian aminoacyl-trna synthetases were purified from rat liver, rabbit liver, and rabbit reticulocytes according to the procedure slightly modified from kellermann et al. [kellermann, o., brevet, a., tonetti, h., & waller, j.-p. (1979) eur. j. biochem. 99, 541-550]. three forms of the synthetase complex with slightly different protein compositions were identified, suggesting a microheterogeneity of the synthetase complex. the hydrodynamic properties and the protei ... | 1988 | 3196691 |
| the rate of dam-mediated dna adenine methylation in escherichia coli. | 1988 | 3074008 | |
| interaction of the bacillus subtilis phage phi 105 repressor dna: a genetic analysis. | the bacillus subtilis phage phi 105 repressor specifically recognizes a 14-bp operator sequence which does not exhibit 2-fold rotational symmetry. to facilitate a genetic analysis of this sequence-dependent dna binding a b. subtilis strain was constructed in which mutations affecting the phi 105 repressor-operator interaction cause a selectable phenotype, chloramphenicol resistance. after in vivo mutagenesis, we isolated and mapped 22 different mutations in the repressor coding sequence, 15 of w ... | 1988 | 3135184 |
| protein c in human plasma determined by homogeneous enzyme immunoassay with use of a centrifugal analyzer. | we describe the simple and rapid enzyme immunoassay of protein c in human plasma with use of a cobas fara centrifugal analyzer. the antibody, labeled with horseradish peroxidase, is reacted with antigen (protein c) for 15 min. the peroxidase activity of the resulting antigen-antibody conjugate is measured at 500 nm for 5 min in the presence of excess h2o2, phenol, and 4-aminoantipyrine, as compared with that of free conjugates. results are calculated from a stored standard curve and expressed as ... | 1988 | 3046778 |
| transitory cardiovascular responses to rapid infusion of blood into aorta of rabbit. | blood (5 to 15 ml) was infused into aorta of the anesthetized rabbit through the carotid artery or femoral artery at a constant rate (0.55 to 8.3 ml/s). the carotid sinuses were occluded. the systemic arterial pressure (sap) began to rise immediately at the onset of the infusion and dropped gradually in most cases during the infusion. sap continued to decline after the infusion and in many cases became lower than the preinfusion pressure. within seconds, sap tapered off to its lowest point and r ... | 1988 | 2902240 |
| transcriptional mapping and nucleotide sequence of the escherichia coli fepa-fes enterobactin region. identification of a unique iron-regulated bidirectional promoter. | the iron-controlled fepa and fes-entf transcripts from the escherichia coli enterobactin gene complex are expressed divergently from a limited genetic region, thereby suggesting the existence of a single, possibly overlapping promoter junction for these genes. the nucleotide sequence of a 1,997-base pair hpai fragment specific for this genetic region allowed for the identification of an 1,122-base pair open reading frame as the previously uncharacterized fes gene. its product, fes (approximately ... | 1988 | 2974033 |
| [a case of metastasis of gastric cancer to spermatic cord]. | a 63-year-old man underwent total gastrectomy and partial resection of the transverse colon for borrman iv gastric cancer on august 27, 1985. on august 8, 1986, 11 months after the operation, he visited our department with chief complaint of swelling of both groins. the spermatic cord was swollen to about 3 cm in diameter from both groins to inside of the scrotum and was hard as a club. the diagnosis of bilateral spermatic cord metastasis of gastric cancer was established and a biopsy was carrie ... | 1988 | 3400551 |
| avermectin toxicity in calves and an evaluation of picrotoxin as an antidote. | 1988 | 3401165 | |
| cancer. gene losses in human tumours. | 1988 | 3419514 | |
| a special role of the parvocellular red nucleus in lesion-induced spontaneous tremor in monkeys. | the neural mechanisms underlying spontaneous tremor were investigated in monkeys. tremor-producing ventromedial tegmental (vmt) lesions involve at least three major neural elements. (1) parvocellular division of the red nucleus (rnpc); (2) cerebellothalamic fibers passing through the red nucleus, and, (3) nigrostriatal fibers. these three elements were destroyed stereotaxically in areas remote from the vmt area separately and/or in various combinations, and correlation between the site of lesion ... | 1988 | 3382517 |
| [neuromuscular junctions of the rat diaphragm in experimental hypoparathyroidism]. | the ultrastructure of neuro-muscular junctions in diaphragm muscle underwent certain changes in the course of experimental hypothyrosis (thermal destruction of a part of parathyroid gland). the most pronounced structural changes were observed in maximum hypocalcemia (7 days after the operation). there was a correlation between the pattern of a transmitter release and some parameters of vesicular apparatus (the number and volume distribution of synaptic vesicles). these effects suggest that hypop ... | 1988 | 3390602 |
| common genetic pools between human populations. | a further inquiry on modern human origins, based on common genetic pool surveys of rigorously selected population samples and highly informative immunological polymorphisms, provides new evidence of an occidental-oriental population split as the origin of human gene pool divergences. the most likely ancestral genetic profile is discussed in the context of the debate raised by preliminary dna restriction fragment length polymorphism studies, which contradict the conclusions drawn from classical b ... | 1988 | 3422217 |
| avian (chicken) parathyroid hormone: synthesis and comparative biological evaluation of the 1-34 fragment. | the full-length amino acid sequence of the avian (chicken) form of parathyroid hormone (cpth) has recently been elucidated. we have chemically synthesized, purified to a high degree, and analytically and biologically characterized the n-terminal 1-34 fragment of the avian hormone. the biological properties of cpth-(1-34)nh2 were evaluated and compared to the bovine fragment bpth-(1-34) in several assays. the potency of cpth-(1-34)nh2 in binding to pth receptors, in stimulating adenylate cyclase ... | 1988 | 2848691 |
| serum and vitreous herpes simplex antibodies in noninfected eyes. | recently, vitreous herpes simplex virus [hsv] antibody titers have been reported from patients with presumed herpetic retinitis. to help understand the significance of these data, we evaluated the hsv type 1 vitreous and serum antibodies in eight patients undergoing pars plana vitrectomy for diabetic vitreous hemorrhage, diabetic traction detachment, or rhegmatogenous retinal detachment. undiluted vitreous and diluted serum specimens were tested for hsv igg antibodies using the fluorescence immu ... | 1988 | 2847623 |
| a library of monoclonal antibodies for exploring unknown functional molecules on the surface of synaptic membrane. | 1988 | 2853561 | |
| derivation of cells with lytic activity against fresh and cultured tumors from human bone marrow. | we studied the derivation of cells with lymphokine-activated killer (lak) cell activity from human bone marrow cultures. in these experiments, 26/26 specimens of human bone marrow obtained from sternum, iliac crest, rib, and humerus cultured with il-2 (1000 u/cc) under varying conditions were able to generate lak activity. lak activity obtained from bone marrow mononuclear cell cultures (bmmc) was observed only with exposure to il-2. peak lak activity against fresh melanomas and renal cell carci ... | 1988 | 3258943 |
| proteasomes (multi-protease complexes) as 20 s ring-shaped particles in a variety of eukaryotic cells. | latent multicatalytic protease complexes, named proteasomes, were purified to apparent homogeneity from various eukaryotic sources, such as human, rat, and chicken liver, xenopus laevis ovary, and yeast (saccharomyces cerevisiae), and their functional and structural properties were compared. they showed latency in breakdown of [methyl-3h]casein, but were greatly activated in various ways, such as by addition of polylysine. they all degraded three types of fluorogenic oligopeptides at the carboxy ... | 1988 | 3141402 |
| insertion sequence is2 in the cyanobacterium chlorogloeopsis fritschii. | a cloned dna fragment, previously demonstrated to encode ribulose bisphosphate carboxylase/oxygenase (rubisco) of chlorogloeopsis fritschii strain ccap1411/1b, is shown also to include the entire transposable element, is2, normally a resident in the escherichia coli genome. southern-blot hybridisation experiments confirm the presence of is2 in the c. fritschii genome. this finding adds a new and unrelated species to the known host range of this element and provides evidence of genetic transfer b ... | 1988 | 2844631 |