Publications

risk of cancer in pesticide applicators in swedish agriculture.	the risk of cancer was analysed in a cohort of 20,245 licensed pesticide applicators in agriculture who had licences issued between 1965 and 1976. most were men (99%) and about 50% had been born in 1935 or later. the cohort was followed up in the swedish cancer register from date of licence until death or 31 december 1982. the mean follow up time was 12.2 years. average time since first exposure was longer, however, since one fifth of the cohort was exposed in the 1950s. a total of 558 malignant ...	2007	2590647
the surface electrocardiogram as a means of refining a murine pressure overload model of congestive heart failure.		1989	2590929
the surface electrocardiogram as a means of refining a murine pressure overload model of congestive heart failure.		1989	2590929
[clinical study of osteoporosis].		2008	2614196
[a case of malignant carcinoid arising in chronic ulcerative colitis].	an unusual case of atypical carcinoid tumor which arose in chronic ulcerative colitis is presented. the authors describe the argyrophilic cell hyperplasia in damaged colonic areas as a possible reaction to injury and the relationship of the carcinoid tumors to the argyrophilic cell hyperplasia.	2009	2626281
injury producing factors in sport parachuting.	on the basis of a study of the literature and a description of the parachute jump, the injury producing factors of civil parachuting is described. the majority of injury happens during landing; the assuming of a correct "prepare to land attitude" and the execution of a good parachute landing fall may prevent a great part of the injuries to the spine and the lower extremities. the factors mentioned are often correlated to ignorance, inexperience or to willful neglect of current regulations. a rev ...	2009	2628641
[the role of the trs-glucotest apparatus in self-monitoring by patients with diabetes mellitus].	successful treatment of diabetes mellitus requires a reliable control of glycaemia where self-monitoring with reflectometer plays a significant role. trs-glucotest reflectometer (trs, zagreb), the result of our experts' efforts, makes it possible for diabetic patients to perform self-monitoring. according to our research trs-glucotest reflectometer shows lower blood glucose levels for more than 20%, especially in 3.8-11.5 mmol/l range of glucose concentration, that is in the range most often exp ...	2009	2633013
[factors in therapeutic decisions].		2009	2652061
cisplatin in the treatment of solid tumors: effect of dose and schedule.		2009	2654403
[the treatment of children with acute respiratory diseases in ambulatory care].		2009	2660430
[corticosteroids and bone tissue].		2009	2664965
comparison of a 550,000 dalton cartilage matrix glycoprotein in cartilage from immature and mature dogs.	cartilage matrix glycoprotein is a disulfide bonded 550,000 dalton protein found in cartilage and in the vitreous of the eye. immunofluorescence studies using a specific antiserum to this glycoprotein have previously demonstrated a difference between the topographic distribution of staining for cartilage matrix glycoprotein in cartilage from immature and mature animals. using a polyclonal antiserum to cartilage matrix glycoprotein, we studied this protein in cartilage from normal immature and ma ...	1989	2666656
evaluation and acute treatment of wide complex tachycardias.	this review will emphasize the initial evaluation and acute treatment of patients with wide complex tachycardias. the evaluation of patients presenting with wide (greater than 120 msec in duration) qrs tachycardias can be an extremely challenging problem. diagnosing the correct mechanism of the tachycardia is necessary to properly prescribe acute and long-term therapy.	2005	2670095
evaluation and acute treatment of wide complex tachycardias.	this review will emphasize the initial evaluation and acute treatment of patients with wide complex tachycardias. the evaluation of patients presenting with wide (greater than 120 msec in duration) qrs tachycardias can be an extremely challenging problem. diagnosing the correct mechanism of the tachycardia is necessary to properly prescribe acute and long-term therapy.	2005	2670095
isolation of a high frequency donor of rhodobacter capsulatus by integration of the plasmid pmt1000 into the chromosome.	the temperature-independent clone of rhodobacter capsulatus ua7041, carrying the temperature-sensitive plasmid pmt1000, has been obtained by selection for plasmid markers at the non-permissive temperature. the transfer to escherichia coli of all drug resistance encoded by pmt1000 was of about 10(-7) when the donor was the ua7041 strain, and of 5 x 10(-4) when the donor was the temperature-sensitive strain of r. capsulatus. electrophoretic analyses showed no plasmid band typical of the autonomous ...	1989	2679770
clozapine: neuroleptic-induced eps and tardive dyskinesia.	clozapine has had a uniquely favorable motor system side effect profile since its initial evaluations. this has been convincingly corroborated by many double blind, single blind, and open studies treating acute and chronic psychosis. the acute extrapyramidal syndromes of dystonia, akathisia and parkinsonism infrequently occur, whereas these syndromes develop in up to 75% of patients receiving traditional neuroleptics. tardive dyskinesia can be suppressed with higher doses of clozapine given over ...	2009	2682732
historical evolution of disease mapping in general and specifically of cancer mapping.	the presentation of areal data in epidemiology is illustrated by such mapping techniques as dots (spots), shading (choropleth, thematic) and isolines (isopleths). examples are also given of computer-assisted cartography (computer graphics) which employs hardware and software components of digital computers, together with the use of geographical and demographic base maps.	2009	2682858
safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast.	deletion of an integrated plasmid, a specific type of intrachromosomal recombination, was evaluated for inducibility with the phenylpropenes safrole, eugenol and methyleugenol in the yeast saccharomyces cerevisiae. these phenylpropenes are found in food products, spices, pharmaceuticals and clove cigarettes. safrole and eugenol are known carcinogens in animals and methyleugenol is a suspected carcinogen. these phenylpropenes are not detectable by the ames assay and most other short-term tests us ...	1989	2685589
safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast.	deletion of an integrated plasmid, a specific type of intrachromosomal recombination, was evaluated for inducibility with the phenylpropenes safrole, eugenol and methyleugenol in the yeast saccharomyces cerevisiae. these phenylpropenes are found in food products, spices, pharmaceuticals and clove cigarettes. safrole and eugenol are known carcinogens in animals and methyleugenol is a suspected carcinogen. these phenylpropenes are not detectable by the ames assay and most other short-term tests us ...	1989	2685589
the paramyxoviridae: aspects of molecular structure, pathogenesis, and immunity.		1989	2690597
treatment of biliary stones using extracorporeal shock waves (eswl).	the use of extracorporeal shock waves (eswl) for the treatment of biliary stones was introduced into medicine in 1985. since then several thousand patients had been treated throughout the world. treatment is reasonably safe, and the best candidates are patients with solitary radiolucent stones in an opacifying gallbladder and those with bile duct stones primarily unamenable to endoscopic measures.	2009	2695443
the effect of dietary interventions to reduce blood pressure in normal humans.	changes in electrolyte intake have been advocated to lower the prevalence of hypertension in the normal population. to elucidate the potential impact of such strategies, we conducted a comprehensive analysis of data from three interventions, namely, salt (nacl) restriction, calcium (ca) supplementation, and potassium (k) supplementation in normal volunteers. eighty-two adults lowered their na intake from 157 +/- 6 s.e. to 68 +/- 3 meq/day for 12 weeks. population mean systolic and diastolic bloo ...	2009	2695549
do renshaw cells tell spinal neurones how to interpret muscle spindle signals?	in vertebrates many alpha motoneurone pools are subjected both to recurrent inhibition via renshaw cells and to proprioceptive feedback via muscle fibres and proprioceptors, particularly spindles. in these cases, the two feedback loops have a common input (alpha motoneurone output) and a common target (alpha motoneurones). this implies that the target alpha motoneurones receive a compound information dispatched by the source alpha motoneurones, but processed in different ways via the two feedbac ...	2009	2699368
demonstration of axonal branching of fibres from certain precerebellar nuclei to the cerebellar cortex and nuclei: a retrograde fluorescent double-labelling study in the cat.	the projections from certain brain stem precerebellar nuclei to the cerebellar cortex and nuclei have been examined in the cat by using the retrograde fluorescent double-labelling technique. crystalline fluoro-gold was implanted into the left cerebellar nuclei from the contralateral side and rhodamine-b-isothiocyanate was injected into the overlying cerebellar cortex. the inferior olive, the lateral reticular nucleus, and the reticular tegmental pontine nucleus all contained double- as well as s ...	1989	2707349
demonstration of axonal branching of fibres from certain precerebellar nuclei to the cerebellar cortex and nuclei: a retrograde fluorescent double-labelling study in the cat.	the projections from certain brain stem precerebellar nuclei to the cerebellar cortex and nuclei have been examined in the cat by using the retrograde fluorescent double-labelling technique. crystalline fluoro-gold was implanted into the left cerebellar nuclei from the contralateral side and rhodamine-b-isothiocyanate was injected into the overlying cerebellar cortex. the inferior olive, the lateral reticular nucleus, and the reticular tegmental pontine nucleus all contained double- as well as s ...	1989	2707349
almitrine bismesylate reduces hypoxic pulmonary vasoconstriction in isolated rat lungs.	the purpose of this study is to test how almitrine bismesylate (alm) affects the function of pulmonary vasculature during normoxic ventilation, and whether low doses of alm not causing detectable vasoconstriction during normoxic ventilation potentiate hypoxic pulmonary vasoconstriction (hpvc). isolated wistar male rat lungs were perfused with homologous blood at constant flow, and venous and ventilatory pressure. in the first experiment, after equilibration, dose-response curves to alm (from 0 t ...	1989	2711381
carrageenan-induced pulmonary emphysema of rabbit.	a transbronchial injection of 0.75% carrageenan in physiologic saline induced pneumonia followed by emphysema in the insulted lobe. in the stages of pneumonia, scattered infiltration of polymorphonuclear leukocytes was seen throughout the affected lobe within a few days of treatment; later this was replaced by the accumulation of carrageenan-laden macrophages, which lasted for one to two months. enlargement of alveoli and alveolar ducts appeared 2 weeks to 2 months after the treatment, and pulmo ...	1989	2711383
incidence and causes of sepsis in glucose-6-phosphate dehydrogenase-deficient newborn infants.	to determine the susceptibility to sepsis in newborn infants deficient in glucose-6-phosphate dehydrogenase (g6pd), we screened 33,943 saudi arab infants. deficiency of g6pd was found in 18%. sepsis was determined by the presence of clinical signs of sepsis and confirmed by positive blood cultures. sepsis was documented in 75 infants (2.2/1000). the incidence of sepsis was significantly higher in 6138 g6pd-deficient infants (3.4/1000) than in the 27,805 with normal g6pd activity (1.9/1000; p les ...	2009	2715888
pulsed er:yag- and 308 nm uv-excimer laser: an in vitro and in vivo study of skin-ablative effects.	using a pulsed xecl excimer laser (308 nm) and a pulsed er:yag laser (2,940 nm), we investigated skin ablation as a function of pulse number, radiant energy, and repetition rate. in vitro analysis of lesions performed in freshly excised human skin were consistent with in vivo results obtained from experiments on pig skin. pulsed 308 nm laser radiation caused considerable nonspecific thermal tissue injury followed by an inflammatory reaction and impaired healing of lesions in vivo. these findings ...	1989	2716457
[the effect isometric exertion on left ventricular function in patients after myocardial infarct].	24 patients, after transmural cardiac infarction, were exposed to isometric exercise ("handgrip"). the haemodynamic response was checked by means of impedance plethysmography. the stroke volume decreased on average from 64 +/- 14 to 60 +/- 15 ml (p less than 0.05), cardiac output increased from 4.8 +/- 1.0 to 5.4 +/- 1.2 l/min. (p less than 0.01). peripheral resistance significantly increased and left ventricular performance was non-significantly reduced. compared with a group of healthy control ...	2008	2720748
insensitivity, limited joint mobility, and plantar ulcers in patients with diabetes mellitus.	the purpose of this study was to determine whether differences in sensation, ankle dorsiflexion (df), and subtalar joint (stj) motion exist between 1) diabetic patients with a history of plantar ulcer (dmw group), 2) diabetic patients without a history of plantar ulcer (dmwo group), and 3) a nondiabetic control group (ndc group). there were 23, 23, and 24 subjects in the respective groups. the mean age for each group was 58, 63, and 60 years, respectively. the mean df for each group was 2, 5, an ...	2009	2727069
the quantitation by radioimmunoassay of 2'-deoxyuridine 5'-triphosphate in extracts of thymidylate synthase-inhibited cells.	a radioimmunoassay (ria) for dutp, with a sensitivity of 3.78 fmol, has been developed. the antibody cross-reacted with dttp so that affinity purification of the immunoglobulin g fraction was required before its use in the ria. cross-reactivity with utp and with mono- and diphosphodeoxyuridylates has necessitated respectively sodium periodate oxidation and anion exchange chromatography of cell extracts, prior to ria quantitation of dutp directly in fractions from the chromatography column. mean ...	1989	2729554
parathyroid carcinoma in a chronic hemodialysis patient.		2009	2739858
"empty sella" with invasive microprolactinoma.	we describe the unique association of an aggressive prolactin secreting pituitary microadenoma invading through the sphenoid sinus with an empty sella, in which the pituitary tumor remained clinically undiagnosed. the postmortem anatomy of this empty sella syndrome is presented. it is concluded that the phrase "empty sella", although universally accepted, correlates poorly with the underlying disease, and that terms such as "intrasellar arachnoidocele" or "intrasellar subarachnoid herniation" wo ...	2009	2743648
type iii machado-joseph disease in a japanese family: a clinicopathological study with special reference to the peripheral nervous system.	the clinical and pathological findings in a 58-year-old japanese man suffering from type iii machado-joseph disease are reported. the patient became affected at the age of 50 years and presented cerebellar ataxia, progressive external ophthalmoplegia and muscular atrophy, although extrapyramidal signs were never detected throughout the whole course of his disease. his mother, sister and son presented progressive ataxia in the third or fourth decade. the mode of inheritance is considered to be au ...	1989	2743650
scintigraphic detection of focal biliary obstruction.		2009	2743698
a fluorescence study of substrate and inhibitor binding to bovine liver dihydrofolate reductase.	1. covalent coupling of fluorescein to methotrexate (mtx) by a 5-carbon spacer yields a dihydrofolate reductase (dhfr) inhibitor (fmtx) with ki = 11 nm. 2. fmtx shows a fluorescence quenching with respect to fluorescein which is relieved by binding to the enzyme. 3. the dissociation constants (kd) of mtx, fmtx, nadph and 7,8-dihydrofolate (dhf) from bovine liver dhfr have been determined by fluorometric titrations. 4. the kd values for nadph, mtx and fmtx from the complementary binary complexes ...	1989	2744204
veterinary opinion.		2009	2750038
time-resolved extrinsic fluorescence of aromatic-l-amino-acid decarboxylase.	the coenzyme-linked fluorescence of aromatic-l-amino-acid decarboxylase decays non-exponentially. the decay of both native and nabh4 reduced samples can only be fitted by two exponentials each roughly accounting for about half of the total fluorescence. denaturation of the reduced protein with 8 m urea makes the fluorescence decay mono-exponential, like that observed for the reference compound pyridoxamine-5-phosphate. an extra pyridoxyl moiety can be bound to the enzyme after incubation with ex ...	1989	2752045
quality-of-life measures.		2005	2754413
abbott and hybritech settle dispute.		2009	2755495
lyme disease prevention--knowledge, beliefs, and behaviors among high school students in an endemic area.	we surveyed 153 high school students in an area highly-endemic for lyme disease. all students were familiar with lyme disease; 14 students reported having had the disease. ninety per cent of students believed tick-avoidance behavior could prevent lyme disease, but fewer than half reported practicing any preventive behaviors. students who believed a specific behavior was preventive were 3-6 times more likely than others to practice that behavior. schools in endemic areas should educate students a ...	2009	2758823
botulinum toxin injection into the superior rectus muscle of the non-dominant eye for dissociated vertical deviation.	a variety of surgical procedures on the superior rectus muscles have been proposed as a remedy for dissociated vertical deviation (dvd); botulinum toxin (oculinum) has been one such suggestion as a surgical alternative. we selected five older patients with dvd whose age placed them beyond a risk of amblyopia to evaluate oculinum injection into the superior rectus muscle as therapy for dvd. the patients achieved a reduction from the mean value of 20 prism diopters to the mean value of less than 5 ...	2009	2760787
perceived distributions of the characteristics of in-group and out-group members: empirical evidence and a computer simulation.	this research studied 2 properties of perceived distributions of the characteristics of social category members: the probability of differentiating (making distinctions) among category members and the perceived variability (variance) of category members. the results of 4 experiments supported the hypothesis that greater familiarity with a social group leads to greater perceived differentiation and variability regarding that group. in-group members formed more differentiated and variable distribu ...	2009	2760805
[prospects for measuring the rheologic characteristics of human soft tissues based on the recording of their transverse rigidity].	it is shown by an example of a forearm that to determine objective characteristics of rheological properties of soft human tissues by measuring their transverse stiffness (k) one should first investigate the relation between k and the diameter of the used indentor (d). the nonlinearity of the dependence k(d) for indentor diameters from 2 to 8 mm is demonstrated and it is assumed that this nonlinearity is due to heterogeneity of tissue properties in the directions normal to the axis of force acti ...	1989	2765581
derived epicardial potentials differentiate ischemic st depression from st depression secondary to st elevation in acute inferior myocardial infarction in humans.	it was hypothesized that in acute inferior wall myocardial infarction, an additional ischemic area in the subendocardium of the noninfarcting territory would produce a selective current dipole between the infarcting and ischemic regions. a resistance network model to calculate epicardial potentials from body surface electrocardiographic potentials was developed and used to examine the hypothesis in 219 patients with acute inferior myocardial infarction. in the learning set of 110 patients, two c ...	2009	2768719
decreased 3 alpha-androstanediol glucuronide levels in plasma and random urines in male pseudohermaphroditism caused by 5 alpha-reductase deficiency.	concentrations of 3 alpha-diol glucuronide (3 alpha-diol g) in plasma and/or random urine samples were determined in seven subjects with familial male pseudohermaphroditism (fmp) due to 5 alpha-reductase deficiency (5 alpha-rd). all subjects were natives of an isolated turkish village with a high incidence of consanguineous marriage. a specific and sensitive antibody to 3 alpha-diol was used for radioimmunoassay of 3 alpha-diol g after hydrolysis and chromatographic purification. the mean plasma ...	1989	2770532
aluminum-binding protein in dialysis dementia. ii. characterization in plasma by ultrafiltration.	ultrafiltration experiments, using amicon membranes with molecular weight exclusions of 1,000, 10,000 and 30,000 daltons, have revealed that desferal, both in vitro and in vivo, markedly increases aluminum ultrafilterability in plasma from patients with dialysis dementia. ultrafilterability was greater with the 10,000-dalton membrane (60%) as compared with the 1,000-dalton membrane (40%); the difference could be related to the presence of an 8,000-dalton aluminum-binding protein in the 10,000-da ...	2009	2770949
community care--up in the air?		2009	2771747
current concepts in trauma: 2. the sunnybrook medical centre trauma program: the first 11 years.	sunnybrook medical centre is a tertiary care teaching hospital situated in metropolitan toronto. its trauma unit, opened in june 1976, serves the inhabitants of metropolitan toronto and the surrounding area (approximately 5 million). more than 3200 patients were admitted to the unit between 1976 and 1987. the criteria for admission were age at least 14 years and an injury severity score (iss) of 16 or greater, two or more significant injuries at anatomically discrete sites when the score on the ...	2009	2776095
pupillographic evaluation of the mydriatic effect of ibopamine solution.	the mydriatic effects of ibopamine solution at the concentrations of 0.25%, 0.50%, 1% and tropicamide solution at the concentration of 1% were evaluated in 22 clinically healthy volunteers. the study was conducted at single dose, instilling 1 drop of each concentration of ibopamine and of tropicamide in one eye and 1 drop of placebo in the other. the pupillary diameter was measured by photographic pupillography immediately before and at 10, 20, 30, 45, 60, 90, 120, 180, 240 min after each instil ...	2009	2777423
[myeloma complicated by amyloidosis of the temporal artery simulating horton's disease].		2009	2782781
selective infection of human cd4+ cells by simian immunodeficiency virus: productive infection associated with envelope glycoprotein-induced fusion.	simian immunodeficiency virus (siv) and human immunodeficiency virus share the property of tropism for cd4-bearing cells. infection is initiated by a high-affinity interaction between cd4 and conserved domains on the viral envelope glycoprotein. in this report, we demonstrated that siv had a restricted host range among human cd4+ cells when compared with human immunodeficiency virus type 1 or type 2. this restricted tropism was associated with the inability of the siv envelope glycoprotein to in ...	1989	2784571
[hemangiopericytoma of the small intestine as a cause of profuse bleeding].		2009	2786977
[desinsertions of aortic valve prostheses treated by subcoronary implantation of the valve].	thirteen patients requiring emergency surgery for desinsertion of their aortic valve prostheses were treated by subcoronary aortic valve grafting, using a procedure based on danielson's method. the particularity characterizing this technique consists in obtaining direct revascularization of the left coronary artery via a coronary sinus approach, thereby reducing the complexity of the surgical operation. all the patients presented valvular ring lesions, associated with aortic root degeneration ac ...	2009	2805927
effect of cck antagonists cr 1409 and cr 1505 on rat pancreatic exocrine secretion in vivo.	the action of cholecystokinin (cck) antagonists cr 1409 and cr 1505 on pancreatic exocrine secretion stimulated by exogenous and endogenous cck was studied in vivo in anesthetized rats, and compared with proglumide. intravenous administration of cr 1409 and cr 1505 in graded doses between 0.04 and 25 mg/kg/h resulted in a dose-dependent inhibition in pancreatic juice volume and amylase output stimulated by intravenous infusion of cck-8 in a dose of 0.06 microgram/kg/h. cr 1409 is 1,000 times and ...	1989	2813333
effect of cck antagonists cr 1409 and cr 1505 on rat pancreatic exocrine secretion in vivo.	the action of cholecystokinin (cck) antagonists cr 1409 and cr 1505 on pancreatic exocrine secretion stimulated by exogenous and endogenous cck was studied in vivo in anesthetized rats, and compared with proglumide. intravenous administration of cr 1409 and cr 1505 in graded doses between 0.04 and 25 mg/kg/h resulted in a dose-dependent inhibition in pancreatic juice volume and amylase output stimulated by intravenous infusion of cck-8 in a dose of 0.06 microgram/kg/h. cr 1409 is 1,000 times and ...	1989	2813333
a clinical trial using a regimen which includes a norgestomet implant and norgestomet plus oestradiol valerate injection as a treatment for anoestrus in dairy cows.	in seasonally calving dairy herds in the macalister irrigation area of gippsland, victoria, cows that had not been observed in oestrus by the start of the mating season and which had inactive ovaries based on rectal palpation and progesterone assay were treated with a hormonal treatment (n = 49). mature cows had calved at least 40 days previously and 2-year-olds had been calved at least 60 days. the treatment consisted of a norgestomet implant and a norgestomet and oestradiol injection on day 1; ...	1987	2820369
the effects of dietary fish oil on hepatic high density and low density lipoprotein receptor activities in the rat.	rats were fed either a standard ration diet or that diet supplemented with 8% by wt of a marine fish oil or safflower oil. after 10 days, plasma triacylglycerols, total cholesterol, high density lipoprotein (hdl) cholesterol, hepatic cholesterol and fatty acid synthesis and hepatic low density lipoprotein (ldl) receptor activity were significantly depressed while hdl receptor activity was significantly increased in rats fed fish oil. fish oil-induced effects on cholesterol metabolism in the rat ...	1987	2820793
the effects of dietary fish oil on hepatic high density and low density lipoprotein receptor activities in the rat.	rats were fed either a standard ration diet or that diet supplemented with 8% by wt of a marine fish oil or safflower oil. after 10 days, plasma triacylglycerols, total cholesterol, high density lipoprotein (hdl) cholesterol, hepatic cholesterol and fatty acid synthesis and hepatic low density lipoprotein (ldl) receptor activity were significantly depressed while hdl receptor activity was significantly increased in rats fed fish oil. fish oil-induced effects on cholesterol metabolism in the rat ...	1987	2820793
onset of steroidogenesis and differentiation of functional lh receptors in rat fetal testicular cultures.	the present study was performed to investigate in vitro the onset of steroidogenesis and the responsiveness to lh in rat fetal testes. the male gonads explanted on days 12.5, 13.5, and 14.5 of gestation in m199 produced testosterone from 15.5 days as is the case in vivo dcamp (1 mm) induced an anticipated steroidogenesis on day 14.5 with secretions of testosterone (0.026 +/- 0.003 ng/gonad/24 h) and progesterone (0.078 +/- 0.005 ng/gonad/24 h), whereas lh (100 ng/ml) has no effect. antiandrogens ...	1987	2823733
plasma cortisol response to opiate receptor blockade during the menstrual cycle.		2010	2836286
neurotransmitter receptor alterations in alzheimer disease: a review.	in alzheimer disease (ad), dysfunction in several neuronal systems is associated with alterations in neurotransmitter receptors. although receptors are important components of normal neural circuitry, their role in the pathophysiology of ad is only beginning to be clarified. for example, despite the consistent loss of presynaptic cholinergic markers in cortex in ad, the pattern of changes in cortical muscarinic cholinergic receptors is unclear, although the density of nicotinic receptors appears ...	2010	2840100
insertion sequence is2 in the cyanobacterium chlorogloeopsis fritschii.	a cloned dna fragment, previously demonstrated to encode ribulose bisphosphate carboxylase/oxygenase (rubisco) of chlorogloeopsis fritschii strain ccap1411/1b, is shown also to include the entire transposable element, is2, normally a resident in the escherichia coli genome. southern-blot hybridisation experiments confirm the presence of is2 in the c. fritschii genome. this finding adds a new and unrelated species to the known host range of this element and provides evidence of genetic transfer b ...	1988	2844631
serum and vitreous herpes simplex antibodies in noninfected eyes.	recently, vitreous herpes simplex virus [hsv] antibody titers have been reported from patients with presumed herpetic retinitis. to help understand the significance of these data, we evaluated the hsv type 1 vitreous and serum antibodies in eight patients undergoing pars plana vitrectomy for diabetic vitreous hemorrhage, diabetic traction detachment, or rhegmatogenous retinal detachment. undiluted vitreous and diluted serum specimens were tested for hsv igg antibodies using the fluorescence immu ...	1988	2847623
the potassium channel opening action of pinacidil; studies using biochemical, ion flux and microelectrode techniques.	in rat aorta and rat portal vein, (-)- and (+)-pinacidil each produced a concentration-dependent inhibition of tension development. although the (-) isomer was the more potent, concentration effect curves for each isomer were steep with similar slopes. in rat portal vein, tetraethylammonium and procaine antagonised the relaxant effect of (+/-)-pinacidil, whereas 3,4-diamino-pyridine was without effect. intracellular microelectrode recording in rat portal vein showed that low concentrations of (+ ...	1988	2848206
the role of diffusible molecules in regulating the cellular differentiation of dictyostelium discoideum.	a central problem in developmental biology is to understand how morphogenetic fields are created and how they act to direct regionalized cellular differentiation. this goal is being pursued in organisms as diverse as moulds, worms, flies, frogs and mice. each organism has evolved its own solution to the challenge of multicellularity but there appear to be common underlying principles and, once pattern formation is fully understood in any system, some general truths seem certain to be revealed. a ...	1988	2848678
avian (chicken) parathyroid hormone: synthesis and comparative biological evaluation of the 1-34 fragment.	the full-length amino acid sequence of the avian (chicken) form of parathyroid hormone (cpth) has recently been elucidated. we have chemically synthesized, purified to a high degree, and analytically and biologically characterized the n-terminal 1-34 fragment of the avian hormone. the biological properties of cpth-(1-34)nh2 were evaluated and compared to the bovine fragment bpth-(1-34) in several assays. the potency of cpth-(1-34)nh2 in binding to pth receptors, in stimulating adenylate cyclase ...	1988	2848691
a library of monoclonal antibodies for exploring unknown functional molecules on the surface of synaptic membrane.		1988	2853561
a simple sensitive prenatal test for hydrops fetalis caused by alpha-thalassaemia.	slot blot analysis was used to differentiate between the genotypes of homozygous alpha-thalassaemia and those of haemoglobin-h disease and alpha-thalassaemia trait. the method is simple and rapid because restriction enzyme digestion and gel electrophoresis are not needed. because of the great sensitivity of the test, as little as 0.5 micrograms of dna can be studied with an 35s-labelled probe which has a longer isotopic half life than the 32p probes normally used for gene mapping. this assay sho ...	2010	2857027
nocturnal enuresis associated with sodium valproate.		2007	2859433
effect of the growth of anaerobic bacteria on the surface ph of solid media.	changes in surface ph occurring after varying periods of anaerobic incubation were measured for a total of 23 test solid media. there was little change in the surface ph of uninoculated plates, but plates inoculated with bacteriodes fragilis showed a striking fall in ph, to ph 5 in the case of some of the test media. the problems of controlling the surface ph of solid media are discussed and possible methods of control are considered.	1985	2860132
peptic ulcer surgery, 1985.		2009	2861560
chloramphenicol in developing countries.		1985	2865547
heat illness and army recruits.		2010	2868240
zinc absorption in inflammatory bowel disease.	zinc absorption was measured in 29 patients with inflammatory bowel disease and a wide spectrum of disease activity to determine its relationship to disease activity, general nutritional state, and zinc status. patients with severe disease requiring either supplementary oral or parenteral nutrition were excluded. the mean 65zncl2 absorption, in the patients, determined using a 65zn and 51cr stool-counting test, 45 +/- 17% (sd), was significantly lower than the values, 54 +/- 16%, in 30 healthy c ...	1986	2873002
enzymes of catecholamine metabolism in the brains of rat strains differing in their preference for or tolerance of ethanol.	the activities of the catecholamine-synthesizing and inactivating enzymes were determined in whole brains of two pairs of rat strains differing in their genetically-determined behavioural responses to ethanol. the alcohol-tolerant (at) rats did not show any significant differences in enzyme activities when compared with the non-tolerant (ant) strain. the activity of tyrosine hydroxylase was found to be significantly higher in brains of the alcohol-preferring (aa) rats, than in those of the alcoh ...	1986	2874817
problems related to diet management of maternal phenylketonuria.	provision of nutritionally complete elemental diets for pregnant women with pku requires greater knowledge of 'conditionally' essential nutrient requirements than is presently available as well as application of known information. formulation of elemental products needs to be improved to enhance aroma and taste and to decrease osmolality. designers of the metal and vitamin components should keep in mind that a major portion (70-80%) of most of these nutrients must be obtained from the elemental ...	2010	2877116
spontaneous oscillation of the systemic arterial pressure during cardiopulmonary bypass in man. the effects of some drugs used during the operation.	despite the fact that the blood flow maintained during cardiopulmonary bypass is rather steady in the extracorporeal pump output, the arterial pressure under high-dose fentanyl anaesthesia quite often shows sinusoidal oscillations. in the present study the duration of an oscillatory cycle was on average 17.6 +/- 3.6 s, its amplitude 7.3 +/- 1.6 mm hg and mean systemic arterial pressure 75 +/- 12 mm hg. the oscillation is affected by the drugs used under bypass conditions. in our series of clinic ...	1987	2886117
human gastrin (gas) rflp recognised by digestion with bamhi or ecori.		1987	2889191
changing association between community occupational structure and ischaemic heart disease mortality in the united states.	the changing association between community occupational structure and ischaemic heart disease mortality in white men and women of the united states from 1968 to 1982 has been investigated. occupational structure was represented by the proportion of workers in white-collar jobs. a negative association, with lower mortality in communities with higher levels of white-collar employment, emerged over the period in both men and women. the results for men may be interpreted as suggesting a recapitulati ...	2010	2889975
somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase.	pharmacological characterization of somatostatin (srif) receptors located on somatotrophs, thyrotrophs, and lactotrophs was attempted by measuring the effects of 14 structural agonists of somatostatin (srif) on the inhibition of basal and grf-stimulated gh and basal and trh-stimulated prl and tsh secretion. we also checked the abilities of the analogs to displace [125i]n-tyr-srif binding to pituitary cell membranes and their potency to inhibit adenylate cyclase activity. there was a very good co ...	1987	2890515
transitory cardiovascular responses to rapid infusion of blood into aorta of rabbit.	blood (5 to 15 ml) was infused into aorta of the anesthetized rabbit through the carotid artery or femoral artery at a constant rate (0.55 to 8.3 ml/s). the carotid sinuses were occluded. the systemic arterial pressure (sap) began to rise immediately at the onset of the infusion and dropped gradually in most cases during the infusion. sap continued to decline after the infusion and in many cases became lower than the preinfusion pressure. within seconds, sap tapered off to its lowest point and r ...	1988	2902240
congenital heart diseases in adults. nursing grand rounds.	diagnosis of significant disease is a major stressor that may interfere with a patient's quality of life. this case study reports the nursing care of a 29-year-old female marathon runner diagnosed with congenital heart disease. the nursing diagnoses, alteration in family process, disturbance in self-esteem, and knowledge deficit are addressed in care plan format.	2010	2913197
impaired oxygenation of gastric mucosa in portal hypertension. the basis for increased susceptibility to injury.	increased susceptibility to mucosal damage is a prominent feature of portal hypertensive gastropathy. since the portal hypertensive gastric mucosa has extensive microvascular changes, we postulated that the increased sensitivity to mucosal damage could have an ischemic basis. we measured distribution of gastric serosal and mucosal oxygenation in a group of portal hypertensive and sham-operated rats, and then studied the effects of intragastric aspirin. in the basal state, gastric mucosa of porta ...	1989	2914542
misunderstanding possible in scope of work.		2010	2922197
lithium and the neonate: developmental and metabolic aspects.	the interrelationship between lithium salts, which has been used in clinical trials of alcoholism, and ethanol, which evoke fetal alcohol syndrome by chronic use, was studied. this was made by evaluating the effect of prenatal and postnatal exposure to licl on ethanol and acetaldehyde metabolizing enzymes in the newborn mouse. the three li-treatment regimens made consisted of acute and short-term prenatal exposure to licl in addition to postnatal exposure until weaning of the neonates. the weane ...	1986	2941034
serine incorporation into the selenocysteine moiety of glutathione peroxidase.	the selenium in mammalian glutathione peroxidase is present as a selenocysteine ([se]cys) moiety incorporated into the peptide backbone 41-47 residues from the n-terminal end. to study the origin of the skeleton of the [se]cys moiety, we perfused isolated rat liver with 14c- or 3h-labeled amino acids for 4 h, purified the gsh peroxidase, derivatized the [se]cys in gsh peroxidase to carboxymethylselenocysteine ([se]cys(cm)), and determined the amino acid specific activity. perfusion with [14c]cys ...	1987	2948953
[clinical characteristics the ent complications of patients with type a (h3n2) influenza during the influenza epidemic in leningrad].		1985	2951903
structural and metabolic correlates of cell injury in the hypertrophied myocardium during valve replacement.	to characterize the ultrastructural and metabolic changes occurring in the hypertrophied ventricle during cardiac operations in man, we studied 36 patients with valvular heart disease undergoing valve replacement, during which multiple doses of cold potassium cardioplegic solution were administered (group i). each patient had substantial ventricular hypertrophy according to measurements made of left ventricular mass, with a mean of 232.1 +/- 19.8 gm/m2 (normal: 92 +/- 16 gm/m2). serial biopsy sp ...	1987	2952840
transcriptional mapping and nucleotide sequence of the escherichia coli fepa-fes enterobactin region. identification of a unique iron-regulated bidirectional promoter.	the iron-controlled fepa and fes-entf transcripts from the escherichia coli enterobactin gene complex are expressed divergently from a limited genetic region, thereby suggesting the existence of a single, possibly overlapping promoter junction for these genes. the nucleotide sequence of a 1,997-base pair hpai fragment specific for this genetic region allowed for the identification of an 1,122-base pair open reading frame as the previously uncharacterized fes gene. its product, fes (approximately ...	1988	2974033
[current approaches to immunological diagnosis of autoimmune and immune complex diseases].		2010	2974642
improved localization of intracellular sites of phosphatases using cerium and cell permeabilization.	a simple permeabilization method has been developed that allows for intracellular localization of acid phosphatase in neutrophils and several types of tissue culture cells with cerium. this permeabilization procedure also facilitates intracellular alkaline phosphatase localization in neutrophils without the loss of cell surface reaction in this cell type. only the cell surface reaction was detected in the absence of permeabilization. glutaraldehyde-fixed cells were permeabilized with detergent d ...	1985	2991362
effects of tunicamycin on ngf binding and neurite outgrowth in pc12 cells.	the effects of inhibition of glycosylation on nerve growth factor (ngf) binding and neurite outgrowth response of pc12 cells have been examined. exposure to tunicamycin (1-10 micrograms/ml) for 24-36 hr eliminates the rapidly dissociating component of ngf binding and decreases the proportion of pc12 cells capable of elaborating neurites in a dose-dependent manner. these decreased cellular responses are probably due to an underglycosylation of the ngf receptor, since the effects of tunicamycin ar ...	1985	2991546
surveillance of enterovirus circulation in children communities.	in three children communities covered by a virological study enteroviruses could be isolated from 19.3% of the stool samples, 52.3% of the sewage samples and 9.7% of the samples taken from different objects and surfaces. the isolates belonged to 14 enterovirus serotypes, coxsackie viruses being predominant. there was a good concordance between the serotypes of enteroviruses shed in the stools and those isolated from the environment. the high epidemiological potential of enteroviruses calls for a ...	1986	3008412
sequence dependent dna conformations: raman spectroscopic studies and a model of action of restriction enzymes.	raman spectra have been examined to clarify the polymorphic forms of dna, a, b, and z forms. from an analysis we found that the guanine ring breathing vibration is sensitive to its local conformation. examination of nine crystals of guanosine residues in which the local conformations are well established revealed that a guanosine residue with a c3'endo-anti gives a strong line at 666 +/- 2 cm-1, o4'endo-anti at 682 cm-1, c1'exo-anti at 673 cm-1, c2'endo-anti at 677 cm-1 and syn-forms around 625 ...	2010	3010660
the adenylate cyclase rebound response to naloxone in the ng108-15 cells. effects of etorphine and other opiates.	the adenylate cyclase (ac) of the neuroblastoma-glioma hybrid cells (ng108-15), is generally considered to be a model for the study of the biochemical correlates of opiate tolerance and dependence. however, the naloxone-induced rebound response of adenylate cyclase, described in some recent reports, is much smaller than that originally described by sharma, klee and nirenberg (1975). possible explanations for these discrepancies are: (1) a marked down-regulation of opioid receptors and tolerance ...	2011	3022177
prostaglandins, thromboxane and leukotriene in human follicular fluid.	the concentrations of prostaglandin e2 (pge2), prostaglandin f2 alpha (pgf2 alpha), thromboxane b2 (txb2) and leukotriene b4 (ltb4) were measured in the follicular fluid of 15 hyperstimulated human follicles. all the samples contained these eicosanoids. ova were recovered in six aspirates; the measured levels of prostanoids and ltb4 did not differ significantly from the levels of nine aspirates without ova. the presence of ltb4 in human follicular fluid suggests that the products of the lipoxyge ...	1986	3022906
chondrosarcoma of the temporal bone. diagnosis and treatment of 13 cases and review of the literature.	chondrosarcoma of the temporal bone is a rare lesion. clinically it has been confused with multiple sclerosis, glomus jugulare tumors, meningioma, and chordomas. the cranial nerve palsies frequently observed with the tumors are related to the anatomic locations of the tumors. thirteen patients with this entity are presented and the eleven other cases in the literature are reviewed. histologically the tumors are low grade and exhibit myxoid features. the myxoid features must be differentiated fro ...	2010	3022910
[cloning of genes for proline biosynthesis in escherichia coli].	restriction map of escherichia coli chromosome fragment (7.4 md) carrying proab genes was constructed. localization of proa and prob genes on the cloned chromosome fragment was determined by complementation test and the measuring of glutamylkinase activity (prob gene product). proa and prob genes were cloned separately on multicopy plasmids of alternative orientation and their expression being, probably, under the control of their own regulatory regions, studied.	1986	3026898