Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| aortic reconstruction vs extra-anatomic bypass and angioplasty. thoughts on evolving a protocol for selection. | one hundred forty-eight patients were evaluated for inflow revascularization and stratified by age, vascular anatomy, medical history, and cardiac functional class into aortic reconstruction (ar), extra-anatomic bypass (eab), or iliac angioplasty based on a protocol that restricted ar to good-risk patients and liberalized indications for eab. fifty-five patients underwent ar with a 1.8% mortality, 1.8% myocardial infarction and 12% morbidity, and cumulative life-table patency of 94% at two years ... | 2010 | 2945536 |
| chondrodysplasia punctata: case report with dental findings. | 2010 | 2942843 | |
| differences in the chromatographic and mass spectral properties of 3,3',5,5'-tetrachlorodiphenoquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. | tetrachlorodiphenoquinones have the same exact mass and elemental composition as the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. however, analysis of 3,3'-5,5'-tetrachlorodiphenoquinone showed a pronounced tendency toward chemical reduction in the mass spectrometer to the quinol compound, producing a molecular ion two mass units higher than 2,3,7,8-tetrachlorodibenzo-p-dioxin. distinct differences were also apparent between the mass spectral fragmentation patterns of 3,3 ... | 2010 | 2937479 |
| pharmacokinetics of trimetrexate (nsc 352122) in monkeys. | the pharmacokinetics of trimetrexate was studied in rhesus monkeys following i.v. bolus, continuous i.v. infusion, oral, and subcutaneous administration. two methods were used to measure drug concentration in plasma, cerebrospinal fluid (csf), and urine: the dihydrofolate reductase inhibition assay, and a reverse phase high-pressure liquid chromatography assay. the pharmacokinetic behavior of trimetrexate was characterized by triexponential plasma disappearance, elimination primarily by biotrans ... | 1986 | 2933145 |
| coexistent cardiac tumours and malformations of the heart. | cardiac tumours and anatomical malformations of the heart may produce similar clinical signs and symptoms. the coexistence of these two abnormalities complicates diagnosis and probably adversely affects prognosis. we present a review of four cases of this rare combination. in the first case, ebstein's malformation was present in a child with tuberous sclerosis and cardiac rhabdomyomata. right ventricular rhabdomyomata were associated with a hypoplastic tricuspid valve in the second case. in the ... | 2010 | 2925289 |
| genu recurvatum due to partial growth arrest of the proximal tibial physis: correction by callus distraction. case report. | the formation of a genu recurvatum after partial growth arrest of the proximal tibial physis is uncommon. this contribution deals with the case of a 16 years old male patient who after a direct injury to the proximal tibia four years ago showed a genu recurvatum of 18 degrees. an incomplete upper tibial corticotomy was performed and a hinge type de bastiani fixator applied. the deformity was corrected at a distraction rate of one millimetre a day. the corticotomy gap filled with callus during th ... | 2010 | 2923531 |
| erosion number and area progression in the wrists and hands of rheumatoid patients: a quantitative microfocal radiographic study. | microfocal radiography has been used to evaluate the relation between erosion number and erosion area in the hands and wrists of 51 patients with early to moderately advanced rheumatoid arthritis. the hands of these patients showed different patterns of erosion progression, in terms of the relation between changes in number and area, and included those showing a decrease in one or both of the erosion parameters. the mean number of erosions in the group increased between the first and second visi ... | 2010 | 2923504 |
| development of spermatozoa in the rhea. | we have examined the ultrastructural changes that take place during spermiogenesis in the rhea. spermatozoa are characterized by a curved head and a midpiece. a thin rod extends from the anterior tip of the spermatozoon through the center of the nucleus. a 3-mu-long distal centriole occupies the entire midpiece. the principal piece is characterized by a small fibrous sheath and tiny dense fibers that are only observed in the region of the principal piece, which is immediately behind the annulus. ... | 2010 | 2923278 |
| risk of cancer from the use of tar bitumen in road works. | tar bitumens are increasingly being used as a binder in road works. they consist of a standard product of about 70% bitumen and 25-30% tar. tar bitumens are classifiable as the pyrolysis products of organic materials and are applied hot. depending on the temperature used there are emissions of various intensities of polycyclic aromatic hydrocarbons (pah), some of which are carcinogenic. a total of 250 one hour air samples was taken at breathing height on 20 days at 11 road works sites. the regio ... | 2010 | 2920140 |
| acquired renal cysts in five-sixths nephrectomized rats: the roles of oxalate deposits in renal tubules and a renotropic factor. | the present study was undertaken to see if the oxalate deposits seen in renal tubules are a causative factor in the development of acquired renal cysts in chronic renal failure. thirty 5/6 nephrectomized rats had free access to water containing 8 mg/ml of vitamin c (oxalate precursor) and 20 5/6 nephrectomized rats were given tap water without vitamin c. oxalate deposits were found on microscopy in the renal tubules of vitamin c-treated rats in the 11th and 12th postnephrectomy months; however, ... | 1989 | 2918951 |
| bladder emptying assessment in stroke patients. | the bladder-emptying status of 85 stroke patients admitted to a comprehensive rehabilitation center was evaluated by postvoid residual (pvr) sequential catheterizations. those patients with incomplete bladder emptying were assessed by scheduled pvrs throughout their hospitalization. incomplete bladder emptying occurred initially in 48 of the 85 patients and was sustained in 28. of this group, 22 were able to void voluntarily and 15 were continent. the incomplete emptying group also demonstrated ... | 2010 | 2916918 |
| fine needle aspiration cytology of clinically suspected local recurrences in breast cancer. | 2010 | 2916364 | |
| one-session treatment for specific phobias. | a rapid and effective treatment for specific phobias, in which the treatment is done in one single session, is described in detail. the treatment method consists of a combination of exposure in vivo and modeling. the short- and long-term outcome for a consecutive series of 20 patients are reported. mean treatment time was 2.1 h and at follow-up after an average of 4 yr 90% were much improved or completely recovered. | 2010 | 2914000 |
| adolescent medicine. | 2010 | 2909971 | |
| mucocutaneous and invasive candidiasis among very low birth weight (less than 1,500 grams) infants in intensive care nurseries: a prospective study. | to determine whether mucocutaneous candidiasis presages the development of invasive candidiasis and to assess factors influencing the development of mucocutaneous candidiasis and invasive candidiasis among infants requiring neonatal intensive care, all infants admitted to our neonatal intensive care unit during a 47-month period were prospectively examined twice weekly for mucocutaneous candidiasis. because 16 of 18 (89%) infants in whom invasive candidiasis (defined by positive cultures of bloo ... | 2010 | 2909957 |
| renal transepithelial transport of nucleosides. | previous work from this and other laboratories has suggested that the mammalian kidney has unique mechanisms for handling purine nucleosides. for example, in humans and in mice, adenosine undergoes net renal reabsorption whereas deoxyadenosine is secreted [kuttesch and nelson: cancer chemother. pharmacol. 8, 221 (1982)]. the relationships between these renal transport systems and classical renal organic cation and anion, carbohydrate, and cell membrane nucleoside transport carriers are not estab ... | 2010 | 2907454 |
| [treatment of childhood asthma]. | the treatment of childhood asthma should be considered with respect to age, severity and aetiology. treatment should be instituted early from the first crisis in order to avoid progression to a more severe form. it consists of two aspects: the treatment of the acute episode and the chronic treatment. the treatment of the acute episode consists of using bronchodilators (bd) (rapid release theophylline and/or beta agonists) to which one might add corticosteroids if the crisis lasts for more than a ... | 2010 | 2905822 |
| cns amyloid proteins in neurodegenerative diseases. | the amyloid plaques found in neurodegenerative diseases show considerable morphologic diversity. two amyloidogenic proteins have been isolated from the brains of humans and animals with neurodegenerative diseases--beta-protein from alzheimer's disease (ad) and down's syndrome, and prion protein (prp) from scrapie and creutzfeldt-jakob disease (cjd). using monoclonal antibodies to a synthetic peptide corresponding to a portion of beta-protein and rabbit antiserum to hamster scrapie prp 27-30, we ... | 1988 | 2901696 |
| isolation and mapping of a polymorphic dna sequence (pmcoc12) on chromosome 14 [d14s20]. | 1988 | 2899879 | |
| acellular pertussis vaccines and fatal infections. | 2010 | 2895385 | |
| a mixed endocrine adrenal tumour causing steatorrhoea. | a 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. adrenoreceptor blockade reversed the symptoms, decreased faecal fat, and increased duodenal trypsin to normal concentrations. after adrenalectomy the patient was asymptomatic and there was no steatorrhoea. the blo ... | 1987 | 2890560 |
| piezoelectric lithotripsy of gallstones. | 2010 | 2890045 | |
| somatostatin 28 and neuropeptide y innervation in the septal area and related cortical and subcortical structures of the human brain. distribution, relationships and evidence for differential coexistence. | somatostatin 28- and neuropeptide y-containing innervations were mapped in the human medial forebrain (eight control brains) with immunohistochemistry, using the sensitive avidin-biotin-peroxidase method. peptidergic perikarya and fibers had an extensive distribution: they were densest in the ventral striatum (nucleus accumbens, olfactory tubercle and bed nucleus of the stria terminalis) and infralimbic cortex, of intermediate density in the medial septal area and of lowest density in the dorsal ... | 1987 | 2888048 |
| homocysteic acid, an endogenous agonist of nmda-receptor: release, neuroactivity and localization. | 1986 | 2878563 | |
| [electrocardiographic, hemodynamic and echocardiographic correlations in young hypertensives during the exercise test]. | 2010 | 2876476 | |
| [a thyroid nodule presenting diagnostic difficulty]. | 2010 | 2876465 | |
| how can you help all those frightened patients? | 2010 | 2876461 | |
| disinfection of endoscopes. | 2008 | 2873178 | |
| differential translation of the genes encoding the proton-translocating atpase of escherichia coli. | translation of the gene for the b subunit of the escherichia coli proton-translocating atpase has been examined. oligonucleotide-directed site-specific mutagenesis was used to mutate certain nucleotides in the intergenic region between unce (c) and uncf (b). one of the changes was predicted to lower the stability of a proposed stem structure which blocked the ribosome binding site of the uncf mrna segment. the result of the mutation is a nearly 3-fold increase in the rate of synthesis of the b p ... | 1986 | 2873137 |
| differential translation of the genes encoding the proton-translocating atpase of escherichia coli. | translation of the gene for the b subunit of the escherichia coli proton-translocating atpase has been examined. oligonucleotide-directed site-specific mutagenesis was used to mutate certain nucleotides in the intergenic region between unce (c) and uncf (b). one of the changes was predicted to lower the stability of a proposed stem structure which blocked the ribosome binding site of the uncf mrna segment. the result of the mutation is a nearly 3-fold increase in the rate of synthesis of the b p ... | 1986 | 2873137 |
| retinoid stimulation of epidermal differentiation in vivo. | retinoids are potent inducers of epidermal hyperplasia in vivo. epidermal transglutaminase activity and stratum corneum turnover were examined in all-trans-retinoic acid and arotinoid ethyl ester treated hairless mice, to evaluate the possible contribution of decreased epidermal cell loss to the induction of hyperplasia by retinoids. stratum corneum turnover was enhanced, and the absolute amounts (activity/cm2), but not the specific activities, of soluble and particulate transglutaminase increas ... | 2010 | 2871471 |
| pharmacology of the ruminant gastroduodenal junction. | 1985 | 2869150 | |
| in-vitro fertilisation for endometriosis. | 2010 | 2863565 | |
| managing acute intussusception. | 2010 | 2863466 | |
| problems with orders for medication as needed. | the safety of an order for medication as needed depends on assumptions and knowledge that may or may not accompany that order. physicians should consider carefully the need for prescribing potent medications on an as-needed basis for newly admitted patients, particularly if these patients have not been examined, their histories are unknown, and no diagnosis has been established. in addition, the language of such orders should leave as little as possible to chance. interpretation of orders should ... | 2010 | 2862797 |
| labelling of liver glutamate by [1-14c]- and [2-14c]-pyruvate as a measure of oxaloacetate-fumarate disequilibrium in the mitochondria. | 1985 | 2860898 | |
| effects of vitamin d3 and related compounds on angiotensin converting enzyme activity of endothelial cells and on release of plasminogen activator from them. | 1988 | 2854501 | |
| effects of vitamin d3 and related compounds on angiotensin converting enzyme activity of endothelial cells and on release of plasminogen activator from them. | 1988 | 2854501 | |
| poland's syndrome: variable expression and associated anomalies. | poland's syndrome is a well-known constellation of congenital anomalies that includes varying degrees of hypoplasia involving the thoracic cage in association with anomalies of the hand. although the latter are most frequently described as syndactyly with short or absent middle phalanges, many forms of expression were seen in a series of 20 patients. thirty-one other anomalies were seen in this group in addition to those usually considered as part of the syndrome. of special interest are those i ... | 2009 | 2852197 |
| gentamicin inhibits agonist stimulation of the phosphatidylinositol cascade in primary cultures of rabbit proximal tubular cells and in rat renal cortex. | a growing body of evidence indicates that aminoglycoside antibiotics interact with phosphoinositides and this has led to the hypothesis that these drugs perturb the phosphatidylinositol (pi) cascade. to test this hypothesis we examined the effect of gentamicin on agonist stimulation of the pi cascade in primary culture of rabbit proximal tubular cells (rptc) and in rat renal cortex. parathyroid (pth) (10(-6) m) stimulated a significant increase in total inositol phosphates, inositol monophosphat ... | 1988 | 2849680 |
| differential effects of (-)-norepinephrine and of (+/-)-isoproterenol on cardiac contraction, an uptake phenomenon. | concentration-dependent inotropic effects of (-)-norepinephrine and of (+/-)-isoproterenol were compared in isometrically contracting guinea pig papillary muscles stimulated at a frequency of 0.2 hz. (-)-norepinephrine (0.1-100 mumol/l) elicited a positive inotropic effect that was not antagonized by carbachol, failed to produce a positive inotropic staircase after resumption of stimulation and shortened relaxation time in a concentration-dependent fashion.(+/-)-isoproterenol had a dual action: ... | 1988 | 2849663 |
| effect of na+/h+ exchange inhibitors on agonist-induced contraction of rat aorta. | a number of vasoconstrictor agonists activate the na+/h+ antiport system in vascular smooth muscle, leading to alkalinization of the cytosol and influx of na+. it is believed that agonist-induced na+/h+ exchange may play an important role in contraction. we have evaluated this hypothesis by determining the effect of inhibition of na+/h+ exchange on phenylephrine (pe)-induced contraction of rat aorta. preincubation of rat aorta with the na+/h+ exchange inhibitor amiloride (0.5 mm) inhibited subse ... | 1988 | 2849662 |
| initiation and characterization of primary mouse kidney epithelial cultures. | primary cultures of murine renal epithelial cells were established from a preparation of proximal tubule fragments. confluent cultures exhibited multiple dome formation, indicating the presence of tight junctions and an intact transcellular transport process. ultrastructural analysis revealed a monolayer of polarized cells, with a sparse but clearly defined microvillar surface facing the growth medium and a basolateral surface attached to the substratum. cultures grown on collagen gels did not s ... | 1988 | 2840432 |
| a one-step preparative method for separating ser 6-phosphorylated hmg 14 from unphosphorylated hmg 14 and in vitro phosphorylation reaction components. | while clear evidence exists for the regulation of the phosphorylation of the very basic high mobility group (hmg) and histone chromatin proteins, the physiological role of their phosphorylation remains poorly understood. elucidation of these roles has been difficult, in part, because of the inability to obtain sufficient quantities of purified phosphorylated derivatives. we have used mono s cation-exchange chromatography to prepare milligram quantities of pure ser 6-phosphorylated hmg 14 (ser 6- ... | 1988 | 2839054 |
| effects of tilomisole, indomethacin and levamisole on regulation of epstein barr virus-induced b cell proliferation by peripheral blood mononuclear cells from normal individuals and patients with rheumatoid arthritis. | when activated in autologous mixed leukocyte reactions (auto-mlr) in vitro, t cells from normal individuals produce a suppressor factor(s) which inhibits the epstein-barr virus (ebv)-induced proliferation of normal b cells. in contrast, t cells from patients with rheumatoid arthritis (ra) are deficient in their ability to generate this suppressor factor in auto-mlr. addition of tilomisole (wy-18,251; 33(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid) to the auto-mlr (0.1-100 microgram ... | 1987 | 2825478 |
| the stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. | platelet-derived growth factor (pdgf) and pdgf-like polypeptides stimulate cell proliferation through paracrine and autocrine pathways. each of these pathways is mediated by the pdgf receptor. recently, cdna clones for the receptor have been isolated and sequenced. the receptor gene on chromosome 5 is transcribed into a single 5.2 kb mrna. the translated product, which is processed through at least one identifiable precursor, is expressed at the cell surface and is rapidly degraded. when activat ... | 2010 | 2824531 |
| stimulation of glucose-6-phosphatase activity in minced muscle autografts on frog gastrocnemius. | 2009 | 2820871 | |
| stimulation of glucose-6-phosphatase activity in minced muscle autografts on frog gastrocnemius. | 2009 | 2820871 | |
| glycoside conjugation in microsomes from hepatic and renal carcinoma of man. | human hepatoma which had been xenografted into nude mice have been estimated for their ability to catalyze glucuronic acid and glucose conjugation of endogenous compounds and p-nitrophenol. the xenobiotic p-nitrophenol was glucuronidated with a comparable rate in microsomes from human hepatoma, human liver and host liver. with regard to glucuronic acid or glucose conjugation of the endogenous compounds of bile acids, bilirubin and steroid hormones, glucosidation of bile acids was the only conjug ... | 1987 | 2820859 |
| glycoside conjugation in microsomes from hepatic and renal carcinoma of man. | human hepatoma which had been xenografted into nude mice have been estimated for their ability to catalyze glucuronic acid and glucose conjugation of endogenous compounds and p-nitrophenol. the xenobiotic p-nitrophenol was glucuronidated with a comparable rate in microsomes from human hepatoma, human liver and host liver. with regard to glucuronic acid or glucose conjugation of the endogenous compounds of bile acids, bilirubin and steroid hormones, glucosidation of bile acids was the only conjug ... | 1987 | 2820859 |
| intra-arterial injection of adriamycin/mitomycin c lipiodol suspension in liver metastases. | intra-arterial injection of a suspension of adriamycin and/or mitomycin c in lipiodol was performed in 17 patients with hepatic metastases, which at angiography were poorly vascularized. accumulation of lipiodol in the tumors was demonstrated at computed tomography (ct) in 15 of 17 patients examined within one week. follow-up with ct showed that lipiodol remained in the tumor during the first month in 94 per cent, after 2 months in 31 per cent, and after 3 months in 17 per cent. in the non-tumor ... | 2010 | 2820453 |
| vitamin b6 levels in patients with carpal tunnel syndrome. | vitamin b6 levels were determined in patients with idiopathic carpal tunnel syndrome. results from this limited study strongly suggest that vitamin b6 deficiency may accompany carpal tunnel syndrome. this study did not address the question of the causal relationship between vitamin b6 status and development of symptoms. | 2010 | 2818188 |
| surgical treatment of gastric carcinoma. | to investigate changes in the results of treatment of gastric carcinoma, two 10-year periods between 1963 and 1982 with 641 and 630 patients, respectively, were compared. in the two groups, 94 percent and 92 percent of patients were operated on. the operation was considered curative in 200 and 265 patients in groups 1 and 2, respectively. there was a shift towards more radical operations, with 215 total or subtotal gastrectomies in group 2 compared with 76 in group 1, when distal gastric resecti ... | 2010 | 2817231 |
| antibiotic irrigation and the formation of intraabdominal adhesions. | the efficacy of antibiotic peritoneal lavage in the prevention of postoperative infection is controversial. the role of intraperitoneally administered cefazolin and tetracycline in the formation of adhesions was studied in the rodent model. thirty-two rats were divided into 3 groups. group 1 underwent midline laparotomy with instillation of 10 ml of normal saline solution. group 2 and group 3 underwent the same procedure with instillation of 0.2 percent saline solutions of cefazolin or tetracycl ... | 1989 | 2817225 |
| [physical exertion of agricultural workers with reference to work in private farms--consequences for occupational health services]. | in terms of social-insurance legislation, the small-scale private work of cooperative agricultural and horticultural workers has the same status as their cooperative-farm work. therefore, it must be included in occupational-hygiene analyses for the evaluation of the physical work load. continuous heart-rate measurements were carried out in 64 people-workers operating can-to-can or pipeline milking facilities, agricultural-machinery mechanics, female horticultural workers and tractor or harvester ... | 2010 | 2815884 |
| effect of mci-186 on ischemia-induced changes in monoamine metabolism in rat brain. | we examined the effects of mci-186 (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger and an inhibitor of ischemia-induced brain edema, on monoamine metabolism in the brains of both normal and ischemic rats. in normal rats, 3 mg/kg i.v. mci-186, a dose that prevents ischemic brain edema, had no significant effect on brain concentrations of dopamine, norepinephrine, 5-hydroxytryptamine, or their metabolites. after the injection of 5 microliters of 3% polyvinyl acetate into the ... | 1989 | 2815191 |
| effect of mci-186 on ischemia-induced changes in monoamine metabolism in rat brain. | we examined the effects of mci-186 (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger and an inhibitor of ischemia-induced brain edema, on monoamine metabolism in the brains of both normal and ischemic rats. in normal rats, 3 mg/kg i.v. mci-186, a dose that prevents ischemic brain edema, had no significant effect on brain concentrations of dopamine, norepinephrine, 5-hydroxytryptamine, or their metabolites. after the injection of 5 microliters of 3% polyvinyl acetate into the ... | 1989 | 2815191 |
| effect of cck antagonists cr 1409 and cr 1505 on rat pancreatic exocrine secretion in vivo. | the action of cholecystokinin (cck) antagonists cr 1409 and cr 1505 on pancreatic exocrine secretion stimulated by exogenous and endogenous cck was studied in vivo in anesthetized rats, and compared with proglumide. intravenous administration of cr 1409 and cr 1505 in graded doses between 0.04 and 25 mg/kg/h resulted in a dose-dependent inhibition in pancreatic juice volume and amylase output stimulated by intravenous infusion of cck-8 in a dose of 0.06 microgram/kg/h. cr 1409 is 1,000 times and ... | 1989 | 2813333 |
| effect of cck antagonists cr 1409 and cr 1505 on rat pancreatic exocrine secretion in vivo. | the action of cholecystokinin (cck) antagonists cr 1409 and cr 1505 on pancreatic exocrine secretion stimulated by exogenous and endogenous cck was studied in vivo in anesthetized rats, and compared with proglumide. intravenous administration of cr 1409 and cr 1505 in graded doses between 0.04 and 25 mg/kg/h resulted in a dose-dependent inhibition in pancreatic juice volume and amylase output stimulated by intravenous infusion of cck-8 in a dose of 0.06 microgram/kg/h. cr 1409 is 1,000 times and ... | 1989 | 2813333 |
| the fibrinolytic system during short-term treatment with tenoxicam. | the effect of 20 mg tenoxicam once daily for 7 days on various components of the fibrinolytic system was studied in 10 healthy volunteers. plasma plasminogen, antithrombin 3, and prekallikrein decreased significantly while plasma plasminogen activator inhibitor increased significantly. the medication did not affect fibrin plate lysis area or the plasma level of plasminogen activator, alpha-2-antiplasmin, alpha-2-macroglobulin, c1 inactivator or factor xii. it is suggested that these changes may ... | 2009 | 2805772 |
| failure of dipyridamole-thallium myocardial imaging to detect severe coronary disease. | three patients referred for peripheral vascular surgery who died of coronary artery disease complications despite normal dipyridamole-thallium scans are discussed. although recent literature has shown enthusiasm for this test in this clinical setting, the dipyridamole-thallium scans are not absolute and patients remain at risk for major coronary artery events. careful clinical screening and awareness of the signs of left main coronary disease on thallium images are important in the evaluation of ... | 2010 | 2805321 |
| failure of dipyridamole-thallium myocardial imaging to detect severe coronary disease. | three patients referred for peripheral vascular surgery who died of coronary artery disease complications despite normal dipyridamole-thallium scans are discussed. although recent literature has shown enthusiasm for this test in this clinical setting, the dipyridamole-thallium scans are not absolute and patients remain at risk for major coronary artery events. careful clinical screening and awareness of the signs of left main coronary disease on thallium images are important in the evaluation of ... | 2010 | 2805321 |
| changes in aldehyde dehydrogenase during rat urinary bladder carcinogenesis. | we have reported that normal rat urinary bladder possesses significant amounts of an aldehyde dehydrogenase (class 3 aldh) expressed during hepatocarcinogenesis, but not detectable in normal liver. changes in expression of both liver and bladder aldh during n-butyl-n-(4-hydroxybutyl) nitrosamine (bbn)-induced bladder carcinogenesis were studied. the aldh phenotype was determined at intervals over 42 weeks by histochemical analysis, total aldh activity assays and gel electrophoresis using propion ... | 1989 | 2805229 |
| changes in aldehyde dehydrogenase during rat urinary bladder carcinogenesis. | we have reported that normal rat urinary bladder possesses significant amounts of an aldehyde dehydrogenase (class 3 aldh) expressed during hepatocarcinogenesis, but not detectable in normal liver. changes in expression of both liver and bladder aldh during n-butyl-n-(4-hydroxybutyl) nitrosamine (bbn)-induced bladder carcinogenesis were studied. the aldh phenotype was determined at intervals over 42 weeks by histochemical analysis, total aldh activity assays and gel electrophoresis using propion ... | 1989 | 2805229 |
| adverse events temporally associated with immunizing agents: 1987 report. | 2007 | 2804852 | |
| granule core loss in eosinophils from a patient with aspirin-induced asthma: an electron microscopic study. | aspirin and other antiinflammatory drugs except steroid hormones precipitate asthmatic attacks in some patients with nasal polyps. the respiratory reaction can be severe and life-threatening. the incidence of nasal polyp found in aspirin-induced asthma ranges from 60% to 100%. this case report concerns a 27-year-old japanese man who has suffered from asthma for 4 years and had attacks of asthma after ingestion of antipyretics. he had nasal polyps and sinusitis. the polyps were removed and examin ... | 1989 | 2802266 |
| dichloroacetic acid and trichloroacetic acid-induced dna strand breaks are independent of peroxisome proliferation. | this study examined whether the induction of single strand breaks in hepatic dna by dichloroacetic acid (dca) and trichloroacetic acid (tca) depends upon peroxisome proliferation. male b6c3f1 mice were given a single oral dose of either dca or tca. at varying times, between 1 and 24 h after administration of the compounds, breaks in dna were measured using an alkaline unwinding assay. peroxisome proliferation was monitored at the same time intervals in a parallel experiment by measuring peroxiso ... | 2009 | 2799828 |
| [effects of air pollutants on the respiratory system in young children]. | a one year study on a random sample of 1225 swiss children aged 0-5 years was conducted in four different areas (two urban, one suburban and one rural) of switzerland to investigate the relationship between air pollution and respiratory symptoms. for each child daily symptoms over a six week period were recorded by their parents in the form of a standard diary and air pollution was assessed by personal no2-samplers. 20% of the diaries were validated by comparison with the attending pediatrician' ... | 2010 | 2799348 |
| plagiarism: justice not seen to be done? | 2009 | 2797158 | |
| garlic (allium sativum) in the treatment of experimental cryptococcosis. | an extract of garlic was studied for its efficacy in treatment experimental cryptococcosis in mice. the garlic, given by mouth, appeared to reduce brain cryptococcal populations, although the results obtained were generally inconsistent. complete eradication of the cryptococci was not achieved and the early beneficial results observed diminished over time. | 2009 | 2795404 |
| axonal signals regulate expression of glia maturation factor-beta in schwann cells: an immunohistochemical study of injured sciatic nerves and cultured schwann cells. | glia maturation factor-beta (gmf-beta) is a 17 kda protein purified and sequenced from bovine brains. using the monoclonal antibody g2-09 directed against gmf-beta, we previously demonstrated endogenous gmf-beta in astroblasts, schwann cells, and their tumors in culture. in the present study, we have used indirect immunofluorescence microscopy with g2-09 to examine the effects of transection, crush, and regeneration of sciatic nerve on the expression of gmf-beta in schwann cells in situ and to s ... | 1989 | 2795149 |
| health care rationing: a problem in ethics and policy. | 2006 | 2794424 | |
| prevalence of chronic periodontal disease using probing depth as a diagnostic test. | the prevalence of chronic periodontal disease was investigated using the occurrence of diseased pocket sites as the diagnostic criterion. the study group comprised 250 dentally aware subjects aged 21-60 years, with a high number of teeth remaining in all age groups. the % of sites with a probing depth of greater than or equal to 4 mm was 16% for the total sample. most diseased sites (69%) were in the 4-mm class, with only 4% at depths greater than or equal to 7 mm. 82% on the subjects had 1 or m ... | 2009 | 2794094 |
| formation of the 1-(s-glutathionyl)-2,4,6-trinitrocyclohexadienate anion at the active site of glutathione s-transferase: evidence for enzymic stabilization of sigma-complex intermediates in nucleophilic aromatic substitution reactions. | formation of the meisenheimer complex or sigma-complex [1-(s-glutathionyl)-2,4,6-trinitrocyclohexadienate] between glutathione (gsh) and 1,3,5-trinitrobenzene (tnb) can be observed at the active sites of isoenzymes 3-3 and 4-4 of rat liver gsh transferase. the spectroscopic properties (uv-visible and cd) of the enzyme-bound sigma-complex are consistent with a 1:1 complex in an asymmetric environment. competitive inhibitors which occupy the gsh binding site (e.g., gamma-l-glutamyl-d,l-2-aminomalo ... | 1989 | 2789999 |
| [single photon emission computed tomography by using n-isopropyl-p-[123i]-iodoamphetamine and 99mtc-hexamethyl propyleneamine oxime in a patient with herpes simplex encephalitis]. | single photon emission computed tomographies (spects) by using n-isopropyl-p-[123i-imp]-iodo-amphetamine (123i-imp) and 99mtc-hexamethyl propyleneamine oxime (99mtc-hm-pao) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (hse), and the chronological changes of accumulations were studied. accumulations of both 123i-imp and 99mtc-hm-pao increased initially, and then decreased with the stage of hse being advanced. the sequential appearance of the lesion in hse with 12 ... | 2009 | 2786584 |
| in-vitro activity of a new penem fce 22101. | the in-vitro activity of a new penem fce 22101 was evaluated in comparison with other antimicrobial agents against 966 aerobic and anaerobic gram-negative and gram-positive bacteria. fce 22101 inhibited 90% of enterobacteriaceae, haemophilus influenzae, h. parainfluenzae, h. ducreyi, neisseria gonorrhoeae, branhamella catarrhalis, staphylococcus aureus, staph. epidermidis and group b streptococcus at concentrations of 0.12-4.0 mg/l. pseudomonas aeruginosa was resistant with mic90 of greater than ... | 1989 | 2786518 |
| compensation of spatial system response in spect with conjugate gradient reconstruction technique. | a procedure for the determination of the system matrix in single photon emission tomography (spect) is described which uses the conjugate gradient reconstruction technique in order to take into account the variable system resolution of a camera equipped with parallel-hole collimators. the procedure involves the acquisition of the system line spread functions (lsf) in the region occupied by the object to be studied. those data are used to generate a set of weighting factors based on the assumptio ... | 2009 | 2784572 |
| mechanism of action of human pancreatic and salivary alpha-amylase on 4,6-ethylidene-alpha-4-nitrophenyl-maltoheptaoside substrate. | 1989 | 2783397 | |
| mechanism of action of human pancreatic and salivary alpha-amylase on 4,6-ethylidene-alpha-4-nitrophenyl-maltoheptaoside substrate. | 1989 | 2783397 | |
| effect of ethanol on hepatotoxicity of acetaminophen in mice and on reactive metabolite formation by mouse and human liver microsomes. | the protective effect of a single dose of ethanol with regard to hepatotoxicity caused by acetaminophen (apap) can be a consequence of either direct or indirect inhibition of apap oxidation to its hepatotoxic intermediate (n-acetyl-p-benzoquinoneimine, napqi), or augmentation of repair mechanisms following the hepatotoxic insult. the mechanism of hepatoprotection appears to be species dependent. by varying the time of ethanol administration relative to apap in mice (30 min before to 240 min afte ... | 1989 | 2781565 |
| combined gastric pull-up and microvascular jejunal transfer procedure after pharyngolaryngoesophagectomy. | a case of simultaneous carcinomas of the lower thoracic esophagus and the oropharynx in a 62-year-old man is reported. reconstruction was successfully performed using a one-stage operation consisting of pharyngolaryngoesophagectomy followed by a combination of gastric pull-up and microvascular jejunal transfer procedures. the postoperative course was uneventful except for regurgitation of food, which persisted for 1 month. | 1989 | 2774731 |
| [the role of hemodialysis and hemosorption in the complex therapy of acute poisoning]. | the method of henosorption and hemodialysis was used in 50 patients with acute intoxication. a total of 44 hemosorption and 40 hemodialysis procedures were carried out in the toxicogenous and somatogenous stage of acute intoxication. results indicate high efficacy of using extracorporal detoxication in the toxicogenous stage of acute poisoning. the method of treatment of acute chemical intoxications is described. | 2009 | 2773412 |
| cohesion, alliance and outcome in group psychotherapy. | cohesiveness has been viewed as the group psychotherapy equivalent of the therapeutic alliance in individual treatment. although researchers have attempted to study the concept of cohesion in group treatment, understanding of this so-called "curative" group factor remains quite primitive. in this study of 12 time-limited psychotherapy groups, with a total of 90 nonpsychotic outpatients, we explore the relationships between cohesion, alliance and treatment outcome. our cohesion measure is a new i ... | 2009 | 2772092 |
| maximum likelihood analysis of free-response receiver operating characteristic (froc) data. | receiver operating characteristic (roc) methodology is widely used in evaluating medical imaging modalities. while appropriate in some cases, it has several drawbacks when the detection task, e.g., nodule detection, involves localizing the abnormality. free-response receiver operating characteristic (froc) methodology offers a more natural framework to describe observer performance in such studies and has other advantages. due to the lack of a statistical analysis procedure comparable to the max ... | 2009 | 2770630 |
| decreased 3 alpha-androstanediol glucuronide levels in plasma and random urines in male pseudohermaphroditism caused by 5 alpha-reductase deficiency. | concentrations of 3 alpha-diol glucuronide (3 alpha-diol g) in plasma and/or random urine samples were determined in seven subjects with familial male pseudohermaphroditism (fmp) due to 5 alpha-reductase deficiency (5 alpha-rd). all subjects were natives of an isolated turkish village with a high incidence of consanguineous marriage. a specific and sensitive antibody to 3 alpha-diol was used for radioimmunoassay of 3 alpha-diol g after hydrolysis and chromatographic purification. the mean plasma ... | 1989 | 2770532 |
| in vivo long-term precision of spinal bone mass measurement by dual photon absorptiometry. | 2006 | 2765710 | |
| immunocytochemical demonstration of neuropeptides in the fish-gill parasite, diclidophora merlangi (monogenoidea). | using the indirect immunofluorescence technique, immunoreactivity (ir) to three mammalian and one invertebrate regulatory peptide has been demonstrated in the nervous system of the monogenean gill parasite diclidophora merlangi. ir to pancreatic polypeptide (pp), peptide tyrosine tyrosine (pyy) and fmrfamide was evident throughout central and peripheral nervous tissues, whereas vasoactive intestinal polypeptide (vip)-ir was confined to a portion of the longitudinal ventral nerve cords. staining ... | 2009 | 2759771 |
| effect of membrane additives on vesicle fusion. | a large variety of alkyl derivatives were found to either slow or block the low-temperature induced fusion of dipalmitoylphosphatidylcholine small unilamellar vesicles (dppc suv) when incorporated into the suv bilayer at five mol%. only corn oil was fusogenic. | 2006 | 2758525 |
| bronchial provocation testing. | 2008 | 2758363 | |
| [moderate deficiency of factor xii associated with postoperative deep venous thrombosis]. | the interrelationship between factor xii deficiency (hageman trait) and thrombosis is well known. a case of moderate factor xii deficiency (activity, 30%) associated to deep vein thrombosis, which occurred in the popliteal region of the left lower limb after abdominal surgery, is reported. the deficit was found in 4 family members of the three generations studied, and all of them showed a close interrelationship between factor xii activity and kallikrein levels. prolonged aptt was found in 3 of ... | 2006 | 2756451 |
| on the art of the abstract. | 2005 | 2756188 | |
| cloning and characterization of bovine cytochrome p-450(11 beta) genes. | we isolated 4 different clones of the p-450(11 beta) gene from a bovine genomic library. these genomic clones were highly homologous with each other. two of the isolated clones were pseudogenes. determination of its nucleotide sequences indicated that the bovine p-450(11 beta) gene is divided into 9 exons by 8 introns and that it is about 8.5 kb in total length. the number of exons and the locations of intron insertion into the p-450(11 beta) gene are identical with those in the case of p-450(sc ... | 1989 | 2753866 |
| thrombectomy for acute deep vein thrombosis: prevention of postthrombotic syndrome. | ninety-six limbs of 89 patients with acute deep vein thrombosis of the lower extremity were followed for 1 to 18 years. in the thrombectomy group (43 limbs), the cumulative incidence of pigmentation at the 15th year was 15%, but no stasis ulcers occurred throughout the follow-up period. in the conservative treatment group (53 limbs), the cumulative incidence of pigmentation at the 15th year was 41%, and that of stasis ulceration was 27%. fogarty thrombectomy restricted below the pelvic vein spur ... | 2006 | 2745537 |
| internal screw fixation: comparison of placement pattern and rigidity. | multiple screw placement patterns and techniques have been described for fixation of the sagittal split ramus osteotomy. this study evaluated transverse strength (rigidity) of six groups of simulated sagittal osteotomies fixed with different screw patterns and placement techniques. osteotomies fixed with screws placed in an inverted l pattern were significantly more rigid than those fixed with screws placed in a linear pattern or k-wires placed in a triangular pattern (p less than .05). no signi ... | 1989 | 2732831 |
| gangrenous ergotism in a suckler herd. | 1989 | 2728284 | |
| comparative study on breast milk of mothers delivering preterm and term infants--protein, fat and lactose. | milk samples were collected from 35 mothers delivering preterm infants and from 35 mothers delivering term infants at 3 time intervals over the first 3 weeks of lactation. the samples were collected by manual expression from both breasts into polyethylene containers and were frozen at -20 degrees c and stored for analysis. the protein content of preterm milks during the first and second weeks is higher than that of term milk (p less than 0.05). the fat and lactose contents during the first week ... | 1989 | 2725632 |
| dynamic interaction between a drosophila transcription factor and rna polymerase ii. | we have purified factor 5, a drosophila rna polymerase ii transcription factor. factor 5 was found to be required for accurate initiation of transcription from specific promoters and also had a dramatic effect on the elongation properties of rna polymerase ii. kinetic studies suggested that factor 5 stimulates the elongation rate of rna polymerase ii on a dc-tailed, double-stranded template by reducing the time spent at the numerous pause sites encountered by the polymerase. the factor was found ... | 2009 | 2725511 |
| regulation of hepatic cortisol sulfotransferase in rats by pituitary growth hormone. | cytosolic sulfating activities of 4-pregnen-11 beta, 17 alpha, 21-triol-3,20-dione (cortisol) to the 21-sulfate were 4 to 5 times higher in livers of female than male adult rats. the activity was decreased by administration of testosterone propionate (tp) to ovariectomized, but not to intact, female rats. in male rats, the rate of cortisol sulfation was elevated by neonatal castration and was restored in part by the administration of tp to the castrated rats. in addition, the sulfating activity ... | 1989 | 2725475 |
| purification of alpha-ketoaldehyde dehydrogenase from the human liver and its possible significance in the control of glycation. | alfa-ketoaldehyde dehydrogenase, which was extracted and purified from human livers, may act on carbonyl compounds, such as 3-deoxyglucosone, and be involved in the control of glycation (maillard reaction) in the body. | 1989 | 2721637 |
| [the clinical value of preoperative staging of bladder and prostatic cancers with nuclear magnetic resonance and computerized tomography]. | to evaluate the diagnostic value of preoperative staging of bladder cancer and cancer of the prostate, ct and nmr scans of 45 histologically defined tumors of the bladder and the scans of 24 patients with radical prostatectomy were compared. lack of extravesical spread was imaged correctly by nmr in all cases of urothelial cancer (pt1-pt3a). ct diagnosis failed in 39%. false-negative results were obtained in 2 of 5 invading tumors (pt3b) by nmr and in 3 of 5 by ct. extraglandular spread of cance ... | 2009 | 2718295 |