Publications

hepatocellular carcinoma in the u.s.a., etiologic considerations. localization of hepatitis b antigens.	the serologic and tissue markers of hepatitis b virus (hbv) were studied in 50 patients in whom hepatocellular carcinoma (hcc) was confirmed at autopsy. serologic and tissue markers included serum hepatitis b surface antigen (hbsag), tissue hbsag, tissue hepatitis core antigen (hbcag), and serum antibody to hbcag (anti-hbc). twenty-two patients had hcc arising in alcoholic cirrhosis; 2 of the 22 (9.1%) had one or more of the hbv tissue and serologic markers. this infection rate is similar to the ...	1979	215488
microbiological aspects of polyphosphate injection in the processing and chill storage of poultry.	during commercial processing of broiler chickens, injection of polyphosphate (puron 604 or 6040) resulted in microorganisms being added to the deep breast muscle. the level of contamination was related to the microbiological condition of the injection solution. injection of polyphosphate had no effect on the shelf-life of fresh chilled carcasses held at 1 degree of 10 degrees c but changes were observed in the growth rate of microorganisms in the deep muscle and in the composition of the muscle ...	1979	216743
xencsa: cell surface antigens related to the major glycoproteins (gp70) of xenotropic murine leukemia viruses.		1979	216748
role of peripheral side chains of vitamin b12 coenzymes in the reaction catalyzed by dioldehydrase.		1979	217415
[state of vascular tone and several blood biochemical indices in experimental atherosclerosis and sensitization].	a study of the vascular tone of the posterior extremities in rabbits, of some blood lipid metabolism indices under conditions of experimental atherosclerosis and sensitization showed an increase in the vascular resistance in the areas investigated, and disturbance of lipid metabolism in two experimental groups of animals. the data obtained support the literature evidence that allergic component serves as one of the factors complicating the atherosclerosis course.	1979	217466
mitochondrial protein-synthesizing machinery in saccharomyces cerevisiae grown in different metabolic conditions. variability of seryl-trna and alanyl-trna isoacceptor patterns.	1. the isoacceptor patterns of mitochondrial seryl and alanyl-trnas from saccharomyces cerevisiae grown under different conditions and committed to fermentative or respiratory metabolism have been studied by reversed-phase chromatography. 2. an extensive variability of the chromatographic patterns of the four isoacceptors for serine and of the three isoacceptors for alanine has been observed as a function of carbon source and stage of growth, but the main differences were observed in the differe ...	1979	381000
in vitro model simulating the form of exposure of bacteria to antimicrobial drugs encountered in infection.	a new model, which is designed to investigate the in vitro activity of antibiotics as a function of different concentration-time curves, is described. the antibiotic is allowed to diffuse through a membrane into a bacterial culture until a peak level is reached; the antibiotic is then removed by flow-assisted back diffusion. with this arrangement it is possible to expose bacteria to a changing concentration of drug while maintaining a constant volume of bacterial culture. preliminary studies wer ...	1979	383014
the inhibitory effect of aspirin on platelet and vascular prostaglandins in rats cannot be completely dissociated.		1979	383131
dnag (primase)-dependent origins of dna replication. nucleotide sequences of the negative strand initiation sites of bacteriophages st-1, phi k, and alpha 3.	the simplest known origins of dna replication occur in the single-stranded bacteriophages. in one set of phages, negative strand synthesis is initiated by a single protein, the product of the escherichia coli replication gene dnag. evidently, in these phages--g4, st-1, phi k, and alpha 3--the origin for negative strand synthesis consists of a nucleic acid element capable of direct recognition by the dnag priming protein. we have located and sequenced the origins of negative strand synthesis in s ...	1979	387790
neurotensin: antinocisponsive action in rodents.		1979	421735
repair of dna in replicated and unreplicated portions of the human genome.		1979	423247
metabolism of 1-beta-d-arabinofuranosyluracil in mouse l5178y cells.		1979	427752
interactions of surface-active alkyltrimethylammonium salts with the plasma membrane of acanthamoeba castellanii.	the interactions of three surface-active alkyltrimethylammonium salts (c12-c16) with the plasma membrane of acanthamoeba castellanii were studied. the surfactants caused a release of k+ from the cells at premicellar concentrations. the lytic effectiveness of the surfactants increased with an increase in the length of the alkyl chain with about an order of magnitude for every two carbon atoms added to the alkyl chain. binding studies with the c16 homologue revealed that at a concentration corresp ...	1979	433611
the contribution of the 'second' visual system to directed visual attention in man.	the visual functions of a patient suffering from a brain lesion incorporating the left n. pulvinar was examined in order to assess the contribution of this structure to human vision. with the exception of the following abnormalities visual functions were normal. first, there was a decrease in the critical flicker frequency in the periphery (but not in the parafoveal region) of the right visual hemifield, that is, that contralateral to the pulvinar lesion. however, the second and most striking ch ...	1979	509197
[first results obtained in man with ethinyl estradiol sulfonate given for various indications (proceedings)].		1979	515140
[response of certain laboratory animals to being fed an ocean fish, the ruvette].		1979	516605
[effect of the emissions caused by the cement industry on biochemical and morphological parameters in rabbits].		1979	516811
isolation of corynebacterial enzymes from cultivation media by gel filtration and ion-exchange chromatography.		1979	524393
isolation of bovine brain microtubule protein without glycerol: polymerization kinetics change during purification cycles.		1979	543557
experimental s. mansoni infection in mice. blood white cells, serum proteins, glycemia and blood urea in various stages of the infection.		1979	545638
characterization of the inotropic response induced by stimulation of beta-adrenergic and h1 histaminergic receptors in guinea pig left atria.	the inotropic response induced by beta-adrenergic and h1 histaminergic receptor stimulation was characterized in guinea pig left atria by obtaining dose-response relationships for isoproterenol and histamine under various experimental conditions. conditions (hypothermia, high frequencies of stimulation, and large extracellular calcium concentrations) which enhanced the ability of cardiac muscle to develop force also increased the sensitivity of the left atrium to isoproterenol while decreasing i ...	1978	217510
sertoli cell capacity to metabolize c19 steroids: variation with age and the effect of follicle-stimulating hormone.		1978	217658
potentiation of coxsackievirus b3 infection in adult mice pretreated with a gold salt.	in mice treated with sodium aurothiomalate (myocrisin), prior to infection with coxsackievirus b3, 90% of the animals died by the 11th day postinfection (p.i.). a mortality of 10% was noted in mice receiving myocrisin only, and no deaths occurred in animals infected with virus alone. the highest amount of virus was recovered from the pancreas of myocrisin-treated mice on day 3 p.i. this was over 500-fold higher than the virus titer found in the pancreas of mice infected with virus only. generall ...	1978	215719
interaction between alpha adrenergic and serotonergic activation of canine saphenous veins.	serotonin and norepinephrine produced concentration-dependent contractions of helical strips of canine saphenous veins. the contractile responses to both agonists were inhibited by the alpha adrenergic receptor blocking agent phentolamine. tolazoline inhibited the contractile responses of canine saphenous veins to norepinephrine but augmented those to serotonin. blockade of adrenergic neuronal reuptake with cocaine enhanced the sensitivity of the canine saphenous vein to serotonin, but did not s ...	1978	215746
stimulation of host dna synthesis and induction of early antigens by ultraviolet light irradiated human cytomegalovirus.	the ultraviolet (uv-)sensitivity of the human cytomegalovirus (hcmv) genes coding for very early complement fixing and early antigens in human embryonic fibroblasts (hef) and mouse embryonic fibroblasts (mef) and the relation of these genes to the ability of the virus to stimulate host cell dna synthesis were investigated. after 14 minutes of uv-irradiation of the virus inoculum only the very early complement fixing nuclear antigen (cmna) developed in the hef cells and only the early cytoplasmic ...	1978	216335
vestibulo-ocular reflex from the posterior canal nerve to extraocular motoneurons in the cat.	in the anesthetized cat, the posterior canal nerve (pcn) was stimulated by electric pulses and synaptic responses were recorded intracellularly in the three antagonistic pairs of extraocular motoneurons. pure reciprocal effects were obtained in the motoneurons innervating the antagonistic pair of ipsilateral oblique muscles and the antagonistic pair of contralateral vertical rectus muscles. these responses consisted of low threshold disynaptic excitatory postsynaptic potentials (epsps) in either ...	1978	210032
enkephalin-like material in normal human csf: measurement and levels.		1978	210344
role of ca++ in virus-induced membrane fusion. ca++ accumulation and ultrastructural changes induced by sendai virus in chicken erythrocytes.	some of the ultrastructural (freeze-etching technique), morphological, and biochemical effects of sendai virus interaction with chicken erythrocytes have been studied under fusogenic (in the presence of cacl2) and nonfusogenic (in the presence of ethyleneglycol-bis-n,n'-tetraacetic acid, [egta]) conditions. the following phenomena occur, irrespective of the presence of cacl2 or egta: (a) binding of iodinated virus particles to chicken erythrocytes at 4 degrees c and their partial release from th ...	1978	211140
detection of antigenically active mutant hgprt after mutagenesis with simian virus 40.		1978	211410
[change in natural immunity under the effect of cysteine].		1978	211758
comparison of interferon action in interferon resistant and sensitive l1210 cells.	translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ...	1978	212514
the lipid-chemical features of the metastatic tissues into the liver from the human gastric cancer, large intestinal cancer and malignant insulinoma.	in order to clarify the biochemical features of metastatic tissues into the liver of human cancerous cells, 12 of primary cancerous tissues and 3 of metastatic tissues of the large intestinal cancer, 6 of primary cancerous tissues and 2 of metastatic tissues of the gastric cancer, and 3 of primary cancerous tissues and 3 of metastatic tissues of malignant insulinoma were studied lipid-chemically. cancerous tissues and metastatic tissues into the liver were collected by biopsy or surgical operati ...	1978	212845
primary afferent depolarisation of tooth pulp afferents is not affected by naloxone.		1978	213729
[technics of measuring the motive force of very small ameboid cells].	a technic have been perfected which measures directly the motive force of very small ameboid cells and indicates the tropism of the amoeba. by using this technic, the motive force of entamoeba histolytica was measured. it varied between +/- 1.5 x 10-4 dyne. we have also shown chimiotactism in entamoeba histolytica. the metabolic coumpound excreted by this cell induced negative tropism.	1978	213820
adenylate cyclase and phosphodiesterase from brain tissue: different stabilities during incubation of cerebral cortical slices.	adenylate cyclase and phosphodiesterase were prepared from brain slices from guinea-pig. the specific activity of adenylate cyclase declined rapidly with increasing incubation time of tissue slices, while phosphodiesterase activity was almost uneffected by the incubation of brain slices.	1978	214325
[antihypoxic effect of analogs of cyclic adenosine monophosphate, phosphodiesterase inhibitors].	a number of investigated camp derivatives are shown to inhibit the camp-phosphodiesterase in brain tissues of white rats in vitro. the 8-substituted aminoethylamino-derivatives proved to be effective inhibitors of the enzyme. among them the most pronounced inhibition displayed the 8-(beta-aminoethylamino)-camp. in an in vitro experiment on the model of hypoxic hypoxia in rats it was shown to possess strong anti-hypoxic properties. the possible prospective clinical use of the camp analogs--inhibi ...	1978	214339
effect of dihydroergotoxine on cyclic-amp-generating systems in rat cerebral cortex slices.	in slices of rat cerebral cortex, cyclic-amp formation is stimulated in response to added noradrenaline (na), isoproterenol (isp) or adenosine. the effect of isp could be antagonized only by the selective beta-adrenoceptor-blocking agent pindolol, whereas the stimulating effect of na could be antagonized by both alpha- and beta-adrenoceptor-blocking agents. dihydroergotoxine (dhet) at low concentrations (10(-8)m) antagonized the stimulating effect of na but not of isp or adenosine, suggesting th ...	1978	201544
prolonged infection of l cells with vesicular stomatitis virus. defective interfering forms and temperature-sensitive mutants as factors in the infection.		1978	206006
[the effect of vitamin d3 on some parameters in the serum and bone of rats (author's transl)].		1978	206364
ca2+/protein modulator-dependent and -independent cyclic gmp phosphodiesterase from hog heart.	ca2+/protein modulator-dependent and -independent guanosine 3':5'-monophosphate (cgmp) phosphodiesterases were separated from hog heart. the protein modulator-free ca2+/protein modulator-dependent enzyme was partially purified by repeated deae-cellulose column chromatography and heat treatment. the final preparation of this enzyme showed no significant basal activity under the standard assay conditions. lineweaver-burk plots of the ca2+/protein modulator-dependent enzyme activity indicated the p ...	1978	207685
histochemical, pharmacological and microspectrofluorometric analysis of new sites of serotonin localization in the rat hypothalamus.	histopharmacological and microspectrofluorometric analysis was applied to the rat hypothalamus for the identification of serotonin. neuronal perikarya, especially certain of those of the endocrinologically important arcuate nucleus, were seen to contain a yellow histofluorescence which possessed spectral characteristics consistent with the serotonin fluorophor. serotonin was localized also within varicosities of various hypothalamic nuclei, as well as within an ependymally associated network of ...	1978	207746
[effect of rations with an increased sunflower seed oil level on the rate of very low-density lipoprotein formation in the liver, secretion into the blood and composition in the blood].	feeding of rats on a ration with an excessive content of sunflower-oil (60 per cent of the total calorific value of the ration) for a period of 30 days resulted in lowering the rate of the apoproteins, prolipoproteins synthesis in the liver and in their loading with triglycerides and cholesterol. as a consequence of this it diminished secretion of endogenously formed tryglycerides and cholesterol from the liver into the blood and a changed lipid composition of lipoproteins of a very low density ...	1978	208301
effect of cortisone on aspartate and alanine aminotransferases in a desert lizard.	1. liver and serum aspartate aminotransferase (got) and alanine aminotransferase (gpt) activities were measured in a hibernating desert lizard, uromastix hardwickii. the levels of both enzymes were found to be lower in hibernation than during the active period, particularly in the liver. 2. after intramuscular injection of 2 mg of cortisone acetate there was a rapid rise in the levels of these enzymes with a peak of 18 hours (got) and 12 hours (gpt). 3. the response of both enzymes to cortisone ...	1978	149452
a study of endotoxemia in ulcerative colitis and crohn's disease. i. clinical study.	endotoxin (lipopolysaccharide, lps) and lps antibody in the blood were studied in 61 cases of ulcerative colitis (u.c.) by radioimmunoassay. lysozyme (lzm) concentration was also studied by the turbidimetric method. as a result, it was found that the blood lps value as well as serum lzm concentration reflects the clinical observations. the case of endotoxemia in the active phase group showed a positive correlation between the lps value and lzm concentration. lps antibody which could not be detec ...	1978	150200
transfer of polychlorinated biphenyls from mothers to foetuses and infants.		1978	103790
production of anti-antipyrine antibody by immunization with 4-azoantipyrine-conjugated bovine serum albumin.		1978	103791
[role of the raphe magnus nucleus in morphine analgesia : studies with intracerebral microinjections in the rat].	microinjections of low concentration of morphine (5 micrograms) into the nucleus raphé magnus of the rat produce a strong analgesia that can be reversed by systemic naloxone, an opiate antagonist. the administration of naloxone (5 micrograms) into the raphé magnus considerably reduces the effects of intravenous morphine. the effects of microinjections of morphine are strongly reduced by cinanserin, suggesting a role for serotoninergic mechanisms in morphine analgesia.	1978	106979
oxygen metabolism by the anaerobic bacterium veillonella alcalescens.		1978	31846
[acid-base equilibrium in mother and fetus during labor and the resistance of newborn calves].	investigated were a total of 59 cows presenting normal processes, of giving birth as well as dystocia, the time of delivery lasting 2, 10, 24, and 36 hours. seventeen cows with dystocia were treated intravenously with 500 cm3 of a 4 per cent solution of sodium bicarbonate and 40 g glucose. it was found that the changes in the ph values, alkali reserves, glycogen, and the peroxydase activity of the neutrophiles in the mothers and fetuses were dependent on the duration of parturition. cases of dif ...	1978	34922
photobehavior of microorganisms: a biophysical approach.		1978	96724
studies on the occurrence of peptococcus indolicus and corynebacterium pyogenes in abscesses in swine, and on the occurrence of pc. indolicus in apparently normal skin and mucous membranes of piglets.	pc. indolicus was isolated from 42.7% and cb. pyogenes from 48.7% of 150 pus-samples from abscesses in pigs (slaughter-house material, table i). in 41 specimens the two organisms were found together. further, pc. indolicus was demonstrated in 22.4% of 290 swabs from apparently normal skin and mucous membranes of piglets (autopsy material, table ii). by gel diffusion analysis the strains of pc. indolicus were referred to the serotypes b, c, d, e, or f. the type distribution (table iii) possibly r ...	1978	98755
production and chemical studies of protease from bacillus subtilis (sh-6) egyptian strain.	bacillus subtilis (sh-6) egyptian strain, isolated from hides, gave the highest protease activity. luxurious growth and protease production were obtained by the use of a medium containing 8% of potato starch, 0,1 m of ammonium phosphate as carbon and nitrogen sources. results indicate that borate buffer exerted a deleterious effect on the protease production. comparing citrate and phosphate buffers, it was found that citrate gave lower protease activity than phosphate. there is a positive respon ...	1978	98932
biological variation of immunoglobulin concentrations in normal human tears related to age and sex.	single radial immunodiffusion method was used to measure the concentration of igg, iga, igm and igd in tears of 220 healthy individuals aged from 2 to 86 years. relation of the values to age and sex has been evaluated statistically by regression analysis method. mean iga level was 30.7 mg/100 ml. igg could be detected in 200 samples and the level was less than 1 mg/100 ml. igm was detected in only 7 samples and the value was less than 1 mg/100 ml. igd could not be detected in any of the sample. ...	1978	98956
[transplantation of langerhans' islands].		1978	99549
ineffectiveness of prophylactic intrathecal methylprednisolone in myelography with aqueous media.	the effectiveness of prophylactic intrathecal methylprednisone (mp) in preventing arachnoiditis from iocarmate myelography was studied. monkeys were injected intrathecally with locarmate, mp, or a combination of the two. twelve weeks later the severity of arachnoiditis was determined in each animal. there was no significant prophylactic effect of intrathecal mp on arachnoiditis from locarmate. some arachnoiditis was found in control animals treated with mp alone.	1978	99764
the isolation and partial characterization of the serum lipoproteins and apolipoproteins of the rainbow trout.	1. vld (very-low-density), ld (low-density) and hd (high-density) lipoproteins were isolated from the serum of trout (salmo gairdneri richardson). 2. each lipoprotein class resembled that of the human in immunological reactivity, electrophoretic behaviour and appearance in the electron microscope. trout ld lipoprotein, however, was of greater density than human ld lipoprotein. 3. the trout lipoproteins have lipid compositions which are similar to those of the corresponding human components, exce ...	1978	100102
alternaria alternata as a cause of opportunistic fungal infections in man.		1978	285458
glycosylation of a membrane protein is restricted to the growing polypeptide chain but is not necessary for insertion as a transmembrane protein.		1978	215329
bovine leucosis in portugal.		1978	224779
influence of specificity of reagents and of behaviour of cell surface ig on the detection and enumeration of immunoglobulin-bearing lymphocytes in humans.	some parameters likely to influence detection and classification of human b-lymphocytes using anti-immunoglobulin (ig) sera have been investigated. of 20 separate mono- and polyspecific native or conjugated anti-ig sera analysed by a passive haemagglutination technique, 13 exhibited non-specific reactivity. this technique showed no consistent correlation between the titre of individual sera against fab2 and whole igg respectively. the indirect immunofluorescence (if) method applied to detect sur ...	1978	307583
osteomyelitis and arthritis caused by salmonella typhimurium in a crow.	salmonella typhimurium was isolated from an arthritic elbow joint of a crow (corvus brachyrhynchos) which also had bilateral osteomyelitis of proximal tibias. the prevalence of salmonella organisms in wild birds is reviewed briefly.	1978	368353
[clinico-laboratory observations of patients with brucellosis].		1978	1186061
comparison of cholesterol egress from cultured cells enriched with cholesterol ester after exposure to cationized ldl or to ldl and chloroquine.		1978	222329
treatment of dehiscent canals in an edentulous mandible.		1978	1091944
wire-guided endoscope passage.		1978	1473685
[humoral immunity indices in children suffering from gastroduodenitis].		1977	432056
a new, highly sensitive and specific assay for chymotrypsin.	1. a simple, highly sensitive, specific fluorometric method for the determination of chymotrypsin is described. 2. the new substrate utilized in this assay, n-glutaryl-glycyl-glycyl-l-phenylalanine beta-naphthylamide (ggpna), is readily soluble in water, stable and highly specific for chymotrypsin. it is not degraded by a large excess of carboxypeptidase b, elastase, thrombin or plasmin and is virtually resistant to trypsin. 3. ggpna is extremely sensitive to the action of chymotrypsin and permi ...	1977	235387
bedside diagnosis of deep venous thrombosis: a myth exposed.		1977	431518
[ring-20 chromosome: a new syndrome].	a comparative study of five observations of a r (20) syndrome characterized by facial dysmorphism, the absence of severe malformations, and rather late onset of encephalopathy and seizures.	1977	305753
stimulation of erythropoiesis in a grafted animal by mouse fetal liver culture media.	erythropoietin given to polycythemic, irradiated mice receiving a bone marrow transplant restores the number of erythroid colonies produced. in this study mouse fetal liver culture media administered to polycythemic, irradiated mice also restored the number of erythroid colonies and erythropoiesis as measured by 59fe incorporation. thus, mouse fetal liver in culture produces a factor which resembles erythropoietin.	1977	321232
suppressor cells in the spleen of tumor-allosensitized mice.	c57bl/6 mice were sensitized i.p. with 20 x 10(6) p-815 mastocytoma cells. spleen and lymph node cells from these tumor-allosensitized mice become hyporesponsive in mixed-lymphocyte culture. the hyporesponsiveness appears to be due to the presence of suppressor cells. these suppressor cells can be demonstrated by their ability to inhibit the mixed-lymphocyte culture reactivity of normal mouse spleen cells. suppressor activity in the spleen of tumor-allosensitized mice remains long after cytotoxi ...	1977	141979
fluorescence of human liver alanine aminopeptidase.	fluorescence of human liver alanine aminopeptidase has been attributed to tryptophan fluorescence. the fluorescence maximum is at 330 nm, 20 nm lower than that for free tryptophan, suggesting that most of the enzyme tryptophans are in a nonpolar environment and are shielded from solvent. quenching of enzyme fluorescence by iodide, pyridine, and n-methyl nicotinamide also demonstrates that enzyme tryptophan residues are largely buried and inaccessible to solvent. those accessible are in negativel ...	1977	143669
nerve conduction velocity of small components in human sensory nerves. studies in normal and diseased nerves.	slow conducted components of sensory nerve action potentials were investigated in median and in sural nerves of controls and in patients with peripheral nerve diseases. in the normal group the slow components showed no relation to age which is in contrast to the maximum velocity. in both the median nerve and sural nerve of about 20% of the patients with neuropathy exclusively a decrease of the conduction velocity of slow components was found, the other investigated parameters were normal. possib ...	1977	210021
fetal mouse lung in circumfusion system cultures.	fetal mouse lungs were cultivated, using the dual-rotary circumfusion system for tissue culture, and their histotypic development was surveyed for 75 days by phase-contrast and electron microscopy. alveoli, terminal bronchioles and alveolar macrophages were photographed periodically with still and time-lapse phase-contrast microscopy. their histotypic appearance was confirmed by electron micrographs of the 1- and 2 1/2-month-old specimens. these revealed typical alveoli surrounded by a basal lam ...	1977	201560
cellular factors. immunologic tolerance: irradiation and bone marrow transplantation in induction of canine allogeneic unresponsiveness.		1977	17203
results of intermittent treatment of growth hormone deficiency with human grwoth hormone.	the growth in stature of two groups of growth hormone deficient children has been compared. the frist group received intermittent treatment with human growth hormone (hgh), 1 year on, 1 year off, subsequent years on; the second group received continous treatment. this latter group had a significantly better mean growth response. the reduction in treatment velocity in years subsequent to the first was not prevented by the year off treatment, the mean velocity of the intermittent group in their 3r ...	1977	194914
rubrospinal effects on ventral spinocerebellar tract neurones.	stimulation of the contralateral red nucleus evoked monosynaptic epsps in 14 of 82 ventral spinocerebellar tract neurones. in some of these cells the monosynaptic epsp was followed by a disynaptic ipsp. the remaining cell population received di- or polysynaptic psps from the rubrospinal tract, either epsps or ipsps or both. convergence of the rubrospinal tract onto interneurones of the segmental pathways projecting to vsct cells was demonstrated. rubrospinal volleys facilitated disynaptic ia ips ...	1976	176875
tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton.	a new dominant mutation, tight-skin (tsk), is located on chromosome 2, two recombination units distal to pallid (pa). heterozygotes (tsk/+) have tight skins with marked hyperplasia of the subcutaneous loose connective tissues, increased growth of cartilage and bone, and small tendons with hyperplasia of the tendon sheaths. in the loose connective tissue there are large accumulations of microfibrils in the intercellular space. in spite of the increased skeletal size, body weight is not increased. ...	1976	176891
re-evaluation of the role of cyclic amp in histamine-induced gastric acid secretion.	the 600 x g particulate fraction of gastric mucosal scrapings from rats was incubated with 3h-metiamide which saturated available binding sites at a concentration of 1 mum. scatchard plots showed a single component with a kd value of 0.2 mum. unlabelled cimetidine and histamine competed with 3h-metiamide binding. the 600 x g particulate fraction also contained all of the hormone and sodium fluoride sensitive adenylyl cyclase. adenylyl cyclase activity was not altered by histamine, pentagastrin o ...	1976	177326
vasopressin-sensitive kidney adenylate cyclase: modulation of the hormonal response.	vasopressin-sensitive pig kidney adenylate cyclase is sensitive to several effectors, such as mg2+, other divalent cations, and guanyl nucleotides. the purpose of the present study was to compare the main characteristics of adenylate cyclase activation by vasopressin, mg2+, and gmppnp, respectively. mg2+ ions were shown to exert at least three different effects on adenylate cyclase. the substrate of the adenylate cyclase reaction is the mg-atp complex. mg2+ interacts with an enzyme regulatory si ...	1976	177820
17 alpha estradiol: separation of estrogen effect on collagen from other clinical and biochemical effects in man.	in rodents the effect of 17alpha estradiol upon collagen is identical to that of 17beta estradiol, but the 17alpha estradiol effect upon uterine lining is 1/1000 that of 17beta estradiol. both steroids reverse the effect of d-penicillamine on rodent skin collagen. five human beings with the skin collagen changes associated with d-penicillamine were treated with 17alpha estradiol for three to six weeks. 17alpha estradiol caused no detectable changes in blood pressure, breast development, menstrua ...	1976	178033
electron microscopic features of lipoprotein-glycosaminoglycan complexes from human atherosclerotic plaques.	lipoprotein-glycosaminoglycan (gag) complexes were isolated from fibrous plaque lesions of human aortas and examined by electron microscopy. after fractionation by gel chromatography and ultracentrifugation, both very low density lopoprotein-gag and low density lopoprotein-gag complexes showed particles which were mainly 1,000 to 2,000 a in diameter. occasional large aggregations 3,000 to 10,000 a in diameter were seen after gel filtration and in the very low density lipoprotein fraction of comp ...	1976	178962
brief communication effects of estradiol on feeding and locomotion in rem deprived rats.		1976	179107
[molecular aspects of the formation of mitochondrial membranes].		1976	179238
fine structural analysis of rabbit synovial cells. ii. fine structure and rosette-forming cells of explant and monolayer cultures.	the fine structure and plasma membrane receptors of explant and monolayer cells of normal rabbit synovium were studied. in explants about 10% of the cells were round and formed rosettes with igc and c3 markers, whereas the remaining cells were stellate, resembled young fibroblasts, and had no receptors for igg and complement. monolayer cells looked like fibroblasts, produced fine extracellular fibrils and hyaluronate, and formed no rosettes. thus early cultures contain both macrophages and fibro ...	1976	181009
type-c rna viruses and leukemogenesis: relation of type-c virus infectivity and leukemogenesis induced by nitrosourea compounds in mice.	correlation between infectivity of type-c rna virus) murine leukemia virus, mlv) and development of leukemia was tested in female icr/jcl mice treated with either 1-ethyl-1-nitrosourea (enu) or 1-butyl-1-nitrosourea (bnu). continuous administration of either chemicals resulted in the occurrence of thymic lymphoma in every mouse with a short latent period. the time of appearance and distribution pattern of mlv infectivity in various tissues were examined by the xc plaque assay technique at fixed ...	1976	187521
a dynamic evaluation of human occlusion.		1976	1066969
scanning and transmission electron microscopy of sheep erythrocyte-rosetting lymphoblasts in a child with acute lymphoblastic leukemia.		1976	1086570
[surface structure of human t and b lymphocytes forming rosettes with erythrocytes in scanning microscopy].	the authors tried to evaluate the surface of t and b cells in scanning microscope. the lymphocytes were isolated from the blood of healthy men and separated into t and b cells on the basis of rosette tests e and eac. about 80% of t cells in type e rosettes showed marked bulgings of surface corresponding to numerous, densely crowded microvilli. the remaining 20% of lymphocytes t had more smooth surface. difficulties were observed frequently in finding differences in the appearance of these cells ...	1976	1086571
[experimental studies on arterialization of the coronary vein system].		1976	1086925
[study of the incorporation of radioactive zinc in saccharomyces cerevisiae aldolase].	saccharomyces cerevisiae aldolase concentrates from the culture medium containing znso4 a large amount of zn which becomes a component part of the enzyme molecular structure. this was made evident by adding to the culture medium 65znso4 and measuring the radioactivity of the aldolase extracted by a phillips single channel analyzer.	1976	133445
hyperactivity induced by tetrahydroisoquinoline derivatives injected into the nucleus accumbens.	several derivatives of tetrahydroisoquinoline were injected bilaterally into the nucleus accumbens of rat 2 h after a nialamide pretreatment and activity recorded in cages fitted with photocells. 1,2,3,4-tetrahydroisoquinoline, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-isoquinoline (tetrahydropapaveroline) and 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline caused virtually no change in locomotor activity and 2-methyl-1,2,3,4-tetrahydrois ...	1976	134899
[super-selective cerebral angiography. iii. diagnostic use and therapeutic possibilities of the telescopic catheterization technic in the circulation area of the external carotid artery in man].	the diagnostic value and technical versatility of the previously described telescopic catheter system was demonstrated in 15 patients by super-selective angiography of the external carotid artery. it was possible in all patients to catheterise the individual branches with the f-catheter; the polyethylene-s-catheter could then be passed 3 to 5 cm, beyond the tip of the f-catheter. in almost half the patients, spasm of the injected artery was observed, particularly of the superficial temporal and ...	1976	134945
the role of the pituitary in acne.		1976	138539
[isoenzymes in neoplasms].		1976	176637
streptococcal m protein extracted by nonionic detergent. i. properties of the antiphagocytic and type-specific molecules.	group a streptococcal m protein was extracted with nonionic detergent and subjected to a number of physical, chemical, and immunological tests. m protein thus extracted was composed of multiple protein bands, ranging from 35,000 down to 6,000 daltons, all having type-specific precipitating activity. the anti-phagocytic proteins, however, were limited to three molecular species having mol wt of 28,000, 31,000, and 35,000 daltons, and could be separated from those proteins that had only type speci ...	1976	58958
electron microscopic evidence for a transsynaptic migration of tetanus toxin in spinal cord motoneurons: an autoradiographic and morphometric study.	adult rats were injected intramuscularly (musculus deltoideus) with 125i-labeled tetanus toxin. first signs of tetanic rigidity became visible 12-13 h after injection: death occurred 1-2 h later. electron microscopic autoradiography of the ventrolateral spinal cord gray matter showed a large part of the radioactivity to be located in motoneurons (perikaryon, axon and dendrites) at 7 and 14 h after injection. a great majority of the rest of the label was found over synaptic terminals, most of the ...	1976	1260442
mao activity and eeg sleep in primary depression.	platelet monoamine oxidase (mao) activity and electroencephalographic (eeg) sleep measures were examined in 56 drug-free hospitalized patients with primary depression as defined by the research diagnostic criteria. the group included 35 females and 21 males with a mean age of 42.6 +/- 1.4 years. platelet mao and eeg sleep data were compared for the group as a whole and separately for the unipolar, bipolar, male, and female subgroups. no significant relationships could be demonstrated for the ent ...	1976	233158
[microinterferometric demonstration of sulfhydryl groups with 1-(4-chlormercuri-phenylazo)-beta-naphtol].		1975	59491
[skin disease in cattle, caused by dermatophilus congolensis].		1975	53909