Publications

in vivo muscle magnetic resonance spectroscopy in a family with mitochondrial cytopathy: a defect in fat metabolism.	in vivo proton and phosphorus magnetic resonance spectroscopy (mrs) studies were performed at 1.5 t on two patients (siblings) diagnosed as having a mitochondrial cytopathy. the clinical diagnosis was based on a complete battery of biochemical tests, electron microscopy and modified gomori trichrome stain studies of muscle. proton spectra from the gastrocnemius muscle were recorded using the stimulated echo acquisition mode (steam) and the phosphorus spectra were obtained using the depth-resolve ...	2009	2716480
regulation of body temperature in postmenopausal women: interactions between bromocriptine and the endogenous opioid system.	the role exerted by the endogenous opioid system on thermoregulation has been studied in nine postmenopausal women before and after the chronic administration of the dopamine agonist bromocriptine (5 mg/day). these women randomly received an infusion of the opioid antagonist naloxone (1.6 mg/h for 4 h) or saline on two consecutive days, before and after 30 days of bromocriptine administration. body temperature as evaluated by rectal temperature, did not vary during saline infusion performed both ...	2009	2716477
scanning electron microscopy of very small fat cells and mature fat cells in human obesity.	to determine the effect of obesity on the size distribution of fat cell populations in human adipose tissue, omental fat tissue biopsies were obtained from lean, moderately obese, and massively obese patients. the size distributions of adipocytes from lean and obese fat tissues examined by the scanning electron microscopic method were bimodal, consisting of populations of very small fat cells and mature fat cells, in contrast to collagenase-derived isolated cells that showed only the large matur ...	1989	2715732
the correlation between family planning program inputs and contraceptive use in indonesia.	using 1980 census and 1986 service statistics program inputs, this paper evaluates the net correlation of socioeconomic, region, and program variables with 1987 contraceptive prevalence and method-specific use rates for indonesian regencies and municipalities. the region variables--primarily, though not exclusively, reflecting program design and maturity--correlate most strongly with the contraceptive prevalence rates. field-worker activities, field-worker supervisor activities, and community-ba ...	2009	2711417
a preliminary survey of parasitic infections and nutritional status among school children in riyadh, saudi arabia.	a total of 320 school children in the model institute of the capital in riyadh, were clinically and parasitologically examined. thirty-five (10.94%) had intestinal parasites. entamoeba coli (61.91%) was found more frequently among the commensals, while giardia lamblia (28.57%) was the most common pathogenic parasite. all urines were parasite free. the low infection rate with gardia could be explained by the good physical and nutritional status and better sanitary and living conditions.	1989	2708849
retroperitoneal approach to aortic surgery.	the retroperitoneal approach has been recently advocated as an alternate approach to abdominal aortic surgery rather than the traditional transperitoneal approach. a comparative analysis of these two approaches was undertaken to clarify the differences. from june 1984 through june 1986, 172 patients underwent elective infrarenal abdominal aortic surgery on the vascular surgery service at eastern virginia medical school. one hundred nineteen were operated through a transperitoneal approach, and 5 ...	2009	2708431
ureteropelvic junction obstruction: treatment with percutaneous endopyelotomy.	the authors review their experience with percutaneous endopyelotomy in the treatment of ureteropelvic junction obstruction. twenty-four patients with symptoms of ureteropelvic junction obstruction underwent excretory urography, which revealed nonspecific narrowing in several cases. angiography was performed in 14 patients suspected of having a vessel crossing at the junction, but such a vessel was found in only four, who subsequently underwent dismembered pyeloplasty. one patient was treated wit ...	2009	2704820
transformation of oocysts from several coccidian species by heat treatment.	the transformation of sporocysts in oocysts of eimeria caviae, e. intestinalis, e. nieschulzi, e. separata, e. tenella, isospora canis, i. heydorni, and toxoplasma gondii by heat treatment was examined. fresh unsporulated oocysts from these species were heated at 50 degrees or 55 degrees c for less than 5 min and cultivated at 25 degrees c for 1 week. no transformation of sporocysts was observed in the sporulated oocysts following heating at 55 degrees c, but sporulated oocysts of tyzzeria and c ...	1989	2704721
sce induction by ccnu and pregnancy.		2009	2704378
licensure: competence to do what?		2006	2702521
[osseointegrated implants. core-vent and screw-vent].	51 variously edentolous patients have been treated by placing 143 core-vent and screw-vent osteointegrated implants. the follow-up ranges from 8 to 20 months. just one implant was removed. the authors explain their surgical method and their considerations about the two different kinds of implants. some clinical cases are reported.	2009	2700964
[biological methods of air purification (review of the literature)].	biological methods of air purification are reviewed, which can be applied to deep air purification of complex multicomponent mixtures from harmful, toxic and odorous substances at room temperature and atmospheric pressure. microbiological and technological aspects of the problem are discussed. operation characteristics of biofilters, bioscrubbers and trickle bed bioreactors are compared. prospects of air biopurification are considered.	2009	2698475
distribution and function of organized concentrations of actin filaments in mammalian spermatogenic cells and sertoli cells.	actin filaments are concentrated in specific regions of spermatogenic cells and sertoli cells. in spermatogenic cells they occur in intercellular bridges and in the subacrosomal space. in sertoli cells they are abundant in ectoplasmic specializations and in regions adjacent to tubulobulbar processes of spermatogenic cells. at all of these sites, the filaments are morphologically related to the plasma membrane and+or intercellular membranes, and, as in many other cell types, are arranged in eithe ...	2009	2695482
the molecular genetics of self-incompatibility in brassica.		2009	2694928
[the intermaxillary relation in complete dentures. 1. determination of vertical dimension].		2009	2687172
mount sinai school of medicine: 25 years.		2005	2685581
[isolation of individual chromosomes and their use in studying the human and animal genome].	this mini-review considers the main achievements in the field of human and animal chromosome separation: technical problems of flow-karyotyping and flow-sorting, the types of cell lines and chromosome source used, different protocols of chromosome suspension preparation, fluorochromes for chromosome staining, efficiency of chromosome sorting and purity of the fractions. the use of fractions for creating chromosome-specific human gene libraries and mapping cloned genes and dna fragment are also c ...	1989	2685546
[isolation of individual chromosomes and their use in studying the human and animal genome].	this mini-review considers the main achievements in the field of human and animal chromosome separation: technical problems of flow-karyotyping and flow-sorting, the types of cell lines and chromosome source used, different protocols of chromosome suspension preparation, fluorochromes for chromosome staining, efficiency of chromosome sorting and purity of the fractions. the use of fractions for creating chromosome-specific human gene libraries and mapping cloned genes and dna fragment are also c ...	1989	2685546
[unilateral pulmonary vein atresia].	a case of unilateral pulmonary vein atresia in a 20-month-old girl is described in this report. a chest x-ray revealed a reticular shadow on the right side, while an electrocardiogram revealed right ventricular hypertrophy. after cardiac catheterization and angiography, a diagnosis of a ventricular septal defect, patent ductus arteriosus, severe pulmonary hypertension, and atresia of the right pulmonary vein was made. the patient underwent an operation for the ventricular septal defect and ligat ...	2009	2681912
obesity.	over the past 20 years, obesity has represented a significant focus of research conducted in clinical research centers (crcs) in the united states. this review will focus on the progress in our understanding of the disease that crc-based research has produced; therefore, the reference list is not exhaustive and consists primarily of crc-based research. obesity is defined as an excess of body fat as measured by triceps skinfold thickness. the time of onset of obesity is an important factor; for e ...	2009	2681326
evolution of dialytic therapy.		2008	2680258
[carcinoma with low malignant potential (borderline tumor) of the ovary: immunomorphology and clinical aspects].	four of 28 patients with borderline tumors of the ovary died of intercurrent disease. twenty-four are alive without clinical evidence of disease, despite the fact that six of them were stage iii; joined with the invasive carcinomas they would distort the survival rates. the development of monoclonal antibodies specific to borderline tumors could improve the value of immunohistochemistry in the diagnosis of borderline tumors. our results show that the rates of expression of ca 125, ca 19-9, and c ...	2009	2679431
[veno-occlusive disease of the liver (a review of the literature)].		2009	2678753
penile pain and direct inguinal hernia.		2009	2676057
properties and incompatibility behavior of miniplasmids derived from the bireplicon plasmid pcg86.	many plasmids belonging to the f incompatibility groups contain more than one basic replicon. the chimeric plasmid pcg86 is an example of such a multireplicon plasmid. the two basic replicons of pcg86, repfiia/fic and repfib have been cloned and re-ligated, the copy numbers of the clones have been determined, and the incompatibility behavior of plasmids containing the ligated replicons and the individual replicons has been studied. the bireplicon plasmids are not expected to be incompatible as r ...	1989	2674652
[renovascular hypertension].		2009	2673734
benjamin collins brodie 1783-1862.		2009	2666664
comprehensive functional assessment of the elderly.	the addition of function assessment in a formalized way into the primary care delivery for elderly patients can be viewed as an extension of the traditional concerns of primary care physicians when asking patients how they are doing. functional assessment strategies simply provide a format for doing this in a reproducible, recordable, and reliable fashion. although the complexity of functional assessment instruments can be intimidating to clinicians, the principles behind instruments of function ...	2008	2664834
nasal obstruction and human communication.	nasal obstruction may cause a variety of communication disorders, particularly in children. the effects of nasal obstruction on hearing, speech, language, and voice are examined. methods for assessing the effects of nasal obstruction are delineated, and recommendations for therapeutic interventions are described.	1989	2664661
[studies on lipid a, the active center of endotoxin--structure-activity relationship].		2008	2664259
the effect of betablockers with and without isa on tonographic outflow facility.	the response of two ophthalmic betablockers, timolol (without isa) and pindolol (with marked isa), on iop and tonographic outflow facility was investigated in a single-blind clinical study on 20 patients with glaucoma or ocular hypertension. in two treatment groups, ten patients each, in a randomized order iop and tonographic outflow facility measurements were performed before and 2 hrs after drug application. timolol reduced iop by 6.8 mm hg and pindolol eye drops by 4.5 mm hg. both topically a ...	2009	2663749
recollections of 60 years of the history of optometry.		2008	2659648
recollections of 60 years of the history of optometry.		2008	2659648
esculetin inhibits t cell activation without suppressing il-2 production or il-2 receptor expression.	esculetin (6,7-dihydroxycoumarin) was found to inhibit dose-dependently the proliferation of human t cells stimulated by pha or phorbolester plus ionomycin. proliferation in autologous and allogeneic mlr and generation of cytotoxic t cells under limiting dilution conditions were also suppressed, with more than 90% inhibition seen at 50 microm esculetin. the immunosuppressive effect of esculetin was not due to toxicity. esculetin did not inhibit interleukin-2 (il-2) production, nor did it interfe ...	1989	2654016
mitochondrial dna mutations and neuromuscular disease.	mitochondrial dna mutations have been identified in patients with certain neuromuscular diseases. point mutations have been associated with maternally inherited diseases, while deletions have been identified in some 'spontaneous' cases.	2009	2652392
beta-thalassaemia--the johannesburg experience.	twenty-nine patients with beta-thalassaemia major were treated in two johannesburg hospitals between 1979 and 1984. they belonged to two ethnic groups--mediterranean and asian--and 53% were under the age of 6 years, the oldest being 20 years. eight patients underwent splenectomy. all were regularly transfused and their quality of life greatly improved. the complication of regular transfusions is iron overload, which contributes to morbidity and mortality. despite adequate iron excretion as a res ...	2009	2652340
pathology and immunopathology of solid organ graft rejection.		2009	2650096
the risks and benefits of low-dose cotrimoxazole prophylaxis for pneumocystis pneumonia in renal transplantation.		2008	2646786
[saliva--the undervalued protection system (1)].		2009	2635966
long residual activity of bacillus sphaericus 1593 against culex quinquefasciatus larvae in artificial pools.	the microbial larvicide, bacillus sphaericus 1593, was evaluated against culex quinquefasciatus larvae in artificial pools at huay kwang area in bangkok between march and october 1985. this study was aimed at determining the residual activity of b. sphaericus 1593 in waste water under field conditions. the larvicidal activity of b. sphaericus 1593 was found to persist for at least 5 months in artificial pools containing waste water. the populations of b. sphaericus 1593 in the test water fluctua ...	1989	2633350
[abstracts of papers presented at the annual meeting of the foundation of research on hormonology. 26 january 1989].		2008	2631029
the rat 78,000 dalton glucose-regulated protein (grp78) as a precursor for the rat steroidogenesis-activator polypeptide (sap): the sap coding sequence is homologous with the terminal end of grp78.	based on the striking sequence identity between the amino acid sequence of rat steroidogenesis-activator polypeptide (sap) and the carboxyl terminus of the 78,000 dalton glucose-regulated protein (grp78), the precursor-product relationship between grp78 and sap was investigated in leydig cells. immunoblot analysis with peptide antibodies specific for grp78 and sap showed that the putative sap precursor is also immunoreactive with the anti-grp78 antibody. genomic blot hybridizations further revea ...	1989	2628731
high-performance liquid chromatographic determination of pirprofen and five of its metabolites in human plasma without hydrolysis and in human urine before and after chemical hydrolysis.	selective high-performance liquid chromatographic methods for the simultaneous determination of pirprofen and five of its metabolites either in plasma or in urine before and after chemical hydrolysis were developed. after addition of an internal standard and a buffer, the compounds were extracted from plasma using reversed-phase c18 bond-elut columns and from urine using pre-packed silica extrelut 1 columns, back-extraction into sodium hydroxide and acidification of the alkaline phase before inj ...	1989	2613803
human lung membrane-bound neutral metallo-endopeptidase-catalyzed hydrolysis of bradykinin.	human lung membrane-bound neutral metallo-endopeptidase (nme; ec 3.4.24.11) has been purified; this enzyme occurred in two forms, nme-i and nme-ii. the total nme activity was purified 2,143-fold with the final specific activities for nme-i and nme-ii being 750 and 1,124, respectively. the two nme forms were resolved in the final purification step involving ion exchange; in all earlier steps including gel filtration and affinity chromatography (phenyl sepharose) both forms behaved similarly and e ...	1989	2612455
human lung membrane-bound neutral metallo-endopeptidase-catalyzed hydrolysis of bradykinin.	human lung membrane-bound neutral metallo-endopeptidase (nme; ec 3.4.24.11) has been purified; this enzyme occurred in two forms, nme-i and nme-ii. the total nme activity was purified 2,143-fold with the final specific activities for nme-i and nme-ii being 750 and 1,124, respectively. the two nme forms were resolved in the final purification step involving ion exchange; in all earlier steps including gel filtration and affinity chromatography (phenyl sepharose) both forms behaved similarly and e ...	1989	2612455
the behaviour of sensory ganglia in relation to their environment.	the nodose ganglion was removed from rats and transplanted into the denervated tongue and into the denervated or innervated sternocleidomastoid muscle. in another procedure the ganglion was sutured to the distal hypoglossal or sciatic nerve. the ganglia failed to develop motor end-plates on denervated muscle. they did, however, induce formation of taste buds on the lingual epithelium. the regenerated nerve fibres ramified extensively within the connective tissue, invading perivascular tissue and ...	1989	2606773
a method for studying rat embryonic metabolism by microcannulation of the vitelline circulation.	a novel technique which involves the cannulation of the vitelline vessels of the 11.5 days rat embryo is described; this has allowed the introduction of both macromolecular and particulate substances directly into the embryo, thus bypassing the digestive and metabolic activity of the visceral yolk sac and facilitating the study of the fate of such substances within the embryo. the method does not affect the growth of the conceptus in vitro providing that inert solutions (e.g. azo blue dye in han ...	1989	2606767
granulopoiesis in tadpoles of rana esculenta. ultrastructural observations on the morphology and development of heterophil and basophil granules.	the morphology and development of heterophil and basophil granules from the trunk kidneys of rana esculenta tadpoles were studied at the electron microscopic level. cells of the heterophils series contain granules displaying either spheroid profiles with homogeneous content (type a), or elongate profiles with a crystalloid interior (type b). type a granules apparently originate directly from golgi-derived vesicles, which, gaining slightly in size and density, transform into the mature granules. ...	2008	2606765
epidermal growth factor promotes chick embryonic angiogenesis.	the response of the early extraembryonic vasculature to epidermal growth factor (egf) was studied. millipore filter discs containing 10ng-1 microgram of egf were placed onto the advancing edge of the area vasculosa of 3-day chick embryos, and the effect examined macroscopically and histologically 24 hours after disc application. the capillary density at the site of application increased significantly, and the effect was seen to be dose-dependent; a similar but more marked response was observed i ...	2006	2605648
[what should be done in a meniscal lesion?].	the treatment of meniscal lesions closely depends on the context in which they occur. in isolated lesions of the medial meniscus, meniscectomy under arthroscopy remains the best method. when the meniscal lesion complicates a rupture of the anterior cruciate ligament, meniscal suture associated with reconstruction of the ligament may be contemplated. in case of degeneration of the medial meniscus or lesion of the lateral meniscus, various therapeutic approaches may be envisaged.	2008	2602876
activation of human natural killer cells by lipopolysaccharide from actinobacillus actinomycetemcomitans.	lipopolysaccharide (lps) from the y4 strain of this bacterium, which is implicated in the pathogenesis of juvenile periodontitis, was incubated with human peripheral blood lymphocytes (pbl) and its action compared to that of lps from escherichia coli. both lps augmented cytotoxicity measured against natural killer (nk) cell-resistant tumour targets within 24 h of incubation. cytotoxicity was exclusively found in nk-enriched low-density large granular lymphocyte fractions, as separated by percoll ...	1989	2597038
in vitro proliferative and cytotoxic responses of pbl from theileria annulata-immune cattle.	peripheral blood lymphocytes were isolated from healthy calves and were subsequently infected with sporozoites of theileria annulata in vitro. the infected cells were passaged for 50 times and thereafter inoculated into animals from which they were previously isolated. within 4-5 days, schizont-containing cells were demonstrable in the lymph nodes of all animals. few days later, merozoites were detected in erythrocytes. a slight decrease in the counts of lymphocytes and leucocytes was also found ...	1989	2596199
[state of the valvular function of the cardia in patients with duodenal ulcer before and after vagotomy and methods of its correction].	the authors studied the valvular function of the cardia in 714 patients who were kept under regular medical observation and in 138 patients who had been operated on for duodenal ulcer. changes were found in the cardia of 9.4% of patients who underwent regular medical examination and in 17% of these subjected to operation. the valvular function of the cardia was impaired after vagotomy in all cases. fundoesophagocrurorhaphy is the best method for correction of cardiac dysfunction.	2008	2593570
total and high-density lipoprotein cholesterol measurements. hazards in clinical interpretation.	duplicate plasma specimens from 24 persons were sent to a community hospital, a commercial laboratory, and a university lipid research laboratory at two separate times to assess the intralaboratory and interlaboratory variations of total and high-density cholesterol measurements. for all three laboratories, the 95% confidence limits for the reproducibility of total cholesterol levels are about +/- 5.5%. for high-density lipoprotein (hdl) values, they are +/- 7%, +/- 14.45%, and +/- 9%. interlabo ...	2008	2588565
[bronchogenic cancer in patients in the diagnostic department of a tuberculosis hospital].		2008	2587559
development of cellular polarity and tight junctions in parotid acinar cells of postnatal rat.	the morphogenesis of acino-tubular structures and cytodifferentiation of acinar cells in developing rat parotid glands from the day of birth to the 7th day after birth were studied by conventional ultrathin-section electron microscopy in conjunction with freeze replica and space tracer methods. an ultrathin-section study indicated that the acinar cells developed sequentially in the order of the following three stages: (1) the stage of undifferentiated cell immediately after birth, in which the p ...	1989	2584909
characterization of elevated plasma alkaline phosphatase activity in genetically obese mice.	alkaline phosphatase activity in obese mice (c57bl/6j ob/ob) was significantly increased from 18 to 63 weeks of age when compared to that of their lean controls (c57bl/6j +/?). in 5 week old animals, the earliest age examined, the circulating activity of alkaline phosphatase was similar in both obese mice and their lean counterparts. to characterize the circulating alkaline phosphatase activity in the obese mouse and its lean counterpart, the response of the enzyme to fasting, various inhibitors ...	1985	2579311
complex membrane transport systems. a non-markovian approach.	this paper suggests a method of how to deal with complex membrane transport systems such as ion channels or ion pumps formed by proteins. the complexity of these systems results from the fact that proteins may undergo an internal dynamics of conformational changes and may thereby affect the transmembrane transport. usually, complex transport systems are mapped into multi-state graphs and couched in terms of markovian master equations. it is shown in this paper how the dimensionality of such mult ...	1985	2578832
functionally different htlv i-infected t cell lines with the same phenotype derived from a patient with melanoma.	two autologous t cell lines infected with htlv i are described. t cells from a patient with malignant melanoma were infected with htlv i by co-culture with a htlv i-producing t cell line, slb i. both t cell lines express identical phenotype (cd3+, cd4+, 4b4+, 2h4-) but they demonstrate marked differences in growth characteristics and function. one of these two lines, referred to as tftx, established from the autologous tumor activated peripheral blood lymphocytes (pbl), grows in culture without ...	1989	2576655
gut size and the digestion of fibrous diets by tetraonid birds.	a series of diets containing different proportions of heather was fed to red grouse. heather is the bird's main natural food and contains much fiber; the rest of each diet was a relatively low-fiber, grain-based formulation. with increasing heather and associated fiber contents, food intake increased and overall digestibility of heather was only 9.4%, but, when heather was eaten as the sole food by wild red grouse, its digestibility was 46%. adaptations to diets containing more heather included ...	2008	2575129
[intranasal gonadorelin in the treatment of cryptorchism].	in 94 outpatients medium aged 4.16 years the lhrh analogues gonadorelin had been administered for 4 weeks. 74 had monolateral cryptorchidism whereas 18 had bilateral cryptorchidism. the results indicate that gonadorelin has a role in treating cryptorchidism. the authors suggest, on its experience, that the gonadorelin should be the first choice of treatment of cryptorchidism.	2008	2572057
the effect of pinealectomy and jejunal loop diversion on rat small bowel crypt cell kinetics.	previously, it was found that diversion of an isolated loop of jejunum into the colon was associated with a significantly diminished crypt cell proliferation rate in the isolated loop, probably principally because of the diminished amount of nutrient available to the diverted mucosa. it has also been shown previously that removal of the pineal gland is associated with a considerable increase in the jejunal crypt cell mitotic rate. in the present investigation it was found that following pinealec ...	1989	2570492
distribution of calcitonin- and somatostatin-containing cells in thyroid lymphoma and in hashimoto's thyroiditis.	eleven cases of thyroid lymphoma were studied by the immunoperoxidase avidin-biotin technique with calcitonin and somatostatin rabbit antisera. in 6 cases of non-hodgkin lymphoma, in thyroid tissue residual to the lymphomatous infiltration, the c cell density was markedly increased and clustering was often observed; the c cells often took part in the follicular lining, frequently with polar distribution; these elements displayed a strong positivity for calcitonin, while the number of somatostati ...	1989	2567176
changes in oligosaccharides of human blood cells measured by tritium- and fitc-labeled lectins after in vitro- and in vivo-irradiation--lectin binding as a 'biological dosemeter'?	the lectin-binding system has been described previously as a biological dosimeter, by revealing induced changes in oligosaccharides of the cell membrane. the measurements were performed by binding [3h]concanavalin a to blood cells. our results on human blood cells irradiated in vitro with doses in the range 0.5-5 gy indicate great difficulties in using radioactive labeled con-a for an accurate quantitative analysis of radiation effects on cell membranes. it appears nearly impossible to different ...	1989	2565944
different 3' end regions strongly influence the level of gene expression in plant cells.	we have investigated the functional role of a 3' end region on the expression of a reporter gene in plant cells. in stably transformed plants, expression of the reporter gene without a plant gene 3' end is variable and depends on the fortuitous presence of polyadenylation signals in the downstream sequences. when the reporter gene is flanked by pbr322 dna, 3'-processing and polyadenylation occurs at (a) cryptic site(s) within these vector sequences. using a transient gene expression system, we p ...	2007	2562510
diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle.	the effect of a diabetic state in the diabetic kk-cay mouse on calcium activated neutral proteinase (canp) of hind-limb skeletal muscles was investigated. in the diabetic state, there was an increased sensitivity to activation of canp by calcium (ca). in addition, there was an enhancement of maximal activity of the enzyme. the effect was induced by secondary modification of the diabetic state, but not genetical factors. several lines of evidence suggest that the canp is responsible for 92 k dalt ...	1989	2561275
melanotic neuroectodermal tumor of infancy.		2008	2556348
the displacement of copper by iron at the specific binding sites of ovotransferrin.	we have examined the kinetics and mechanism by which iron can displace copper at the specific metal-binding sites of ovotransferrin. fe2+ was added to cu2+-ovotransferrin-co3(2-) in the presence of nahco3 and ambient o2. the reaction has been followed by standard and stopped-flow spectrophotometry, epr spectroscopy and analysis of chromogen-reactive fe2+. the reaction is best described as triphasic. an initial jump in absorbance takes place in the first 2 s. in the next minute there is a further ...	2008	2547450
t-cell antigen receptor beta-chain variable region families: a study of their distribution in normal and reactive tissues.	the beta chain of the t-cell antigen receptor is constructed using a variable region gene from one of approximately 20 variable gene families. antibodies that react with the products of these gene families have been used to demonstrate clonal proliferation of t cells. here, we describe the expression of two beta-chain variable region families in normal and reactive lymphoid tissues. in all the tissues studied, expression was scattered throughout the t-cell areas, without any clustering of expres ...	2008	2547047
[various principles of the organization of nephrologic and urologic services for children].		2008	2528118
[expressions of 2h4 and 4b4 antigens on atl cells].	we studied the expression of 2h4 and 4b4 on the surfaces of leukemia cells from 17 patients with adult t-cell leukemia (atl) as well as of cells belonging to 2 t-cell lines derived from atl patients. the effects of the supernatants obtained from culture fluids of the atl cells and the t-cell lines on igg production of a human b-cell line, cess cells, were also examined. on the surfaces of the atl cells from 15 out of 17 cases and of the cells of 2 t-cell lines 4b4 obviously existed at higher per ...	1989	2528006
[the effect of food consistency on conditioned avoidance response in mice and rats].	the purpose of this study was to examine the effects of chewing a hard and soft diet on acquisition of conditioned avoidance response in mice and rats. 76 c57bl mice and 38 wistar rats were divided into 2 groups respectively 20 days after birth. one group was fed a solid diet and another was fed a powder diet containing the same components as the solid one (nihon crea company, ce-2). using the avoidance conditioning system of gunma university, conditioned avoidance experiments started at the age ...	1989	2519255
once upon a synapse: a drug education simulation in three acts.		2008	2516518
a benign sickle-cell disease in a saudi subject with beta zero-thalassemia and glucose-6-phosphate dehydrogenase deficiency.	sickle-cell disease with raised fetal hemoglobin is found relatively frequently in the eastern part of the arabian peninsula. in contrast to the severe and sometimes life-threatening complications of sickle-cell disease in the black population, saudi arabs homozygotes for hbs gene exhibit a mild course for this disease. here we present a saudi sickle-cell patient with an unusually low fetal hemoglobin level. moreover, this individual has beta 0-thalassemia and a deficiency in the enzyme glucose- ...	2008	2474488
[persistence of antibodies of the igg class against cytomegaloviruses in blood donors].	high titre plasmas gained from blood donors are the initial material used for producing human immunoglobulin containing cytomegalovirus antibodies (cmv-hig). for this purpose the sera gained from 467 permanent donors at the district institute for blood and transfusion service in berlin were investigated on their cmv antibody content of igg class by means of an indirect immunofluorescence test (ift). the infection rate of blood donors amounted to 62% (291/467). cmv-igg titre greater than or equal ...	1987	2446998
silver staining of native and denatured eucaryotic dna in agarose gels.	a modified method of silver staining for native and denatured eucaryotic dna in 1% agarose gel is described. this method is at least fivefold more sensitive than ethidium bromide staining, with a detection limit of 2.5 ng for total dna. the calibration curve is linear within the range 5-30 ng of single-stranded and double-stranded dna. this method is especially advantageous for electrophoretic assessment of dna molecular weights.	2008	2446526
human amnion cells: modulation of expression of specific antigens.	antigen expression by fetal cells near the mother is of interest because of the possibility that some antigens may stimulate beneficial maternal immune responses or may prevent the development of harmful responses. the recent generation of monoclonal antibodies to amnion and trophoblast antigens together with the finding that class i histocompatibility antigen (hla) expression by amnion cells can be manipulated provided an opportunity to determine if any relationships exist among expression of h ...	1987	2442388
human amnion cells: modulation of expression of specific antigens.	antigen expression by fetal cells near the mother is of interest because of the possibility that some antigens may stimulate beneficial maternal immune responses or may prevent the development of harmful responses. the recent generation of monoclonal antibodies to amnion and trophoblast antigens together with the finding that class i histocompatibility antigen (hla) expression by amnion cells can be manipulated provided an opportunity to determine if any relationships exist among expression of h ...	1987	2442388
synaptophysin expressed in the bronchopulmonary tract: neuroendocrine cells, neuroepithelial bodies, and neuroendocrine neoplasms.	synaptophysin is an integral membrane glycoprotein with an mr of 38,000 that occurs in the small, clear vesicles present in neuronal cells and tumors as well as in pancreatic islet cells and various neuroendocrine (ne) carcinomas. we found that synaptophysin is also expressed in normal ne cells of the lungs of newborn rabbits and mice as well as of human fetuses. in bronchial ganglion cells and in nerves, synaptophysin is coexpressed with neurofilament proteins (nfps), whereas in solitary ne cel ...	1987	2442053
effect of gastroduodenostomy on intestinal vasoactive intestinal peptide (vip) levels, and vip binding and vip stimulation of cyclic amp in intestinal epithelial cells from rat.	the concentration of vip in duodenum and jejunum as well as the interaction of vip (binding and stimulation of cyclic amp accumulation) with epithelial cells from both gut segments were studied in rats after surgical bypass of the pylorus by gastroduodenostomy. duodenal vip concentration increased in rats with gastroduodenostomy as compared to sham-operated animals. the binding capacity (but not the affinity) of vip binding sites and the efficiency (but not the potency) of vip on cyclic amp accu ...	1987	2440464
cotranscription of the escherichia coli isoleucyl-trna synthetase (iles) and prolipoprotein signal peptidase (lsp) genes. fine-structure mapping of the lsp internal promoter.	we have applied the technique of northern blotting hybridization analysis to examine the transcription of the escherichia coli isoleucyl-trna synthetase (iles) and prolipoprotein signal peptidase (lsp) genes. rna samples from the wild-type strain cs412 and cs412 containing the plasmids pmt521 and psyc890 were examined with iles- and lsp-specific 32p-labeled probes. pmt521 is a pbr322 derivative into which a chromosomal dna fragment containing the iles and lsp genes has been cloned downstream of ...	1987	2432063
[chronic poisoning by wood-protective agents in living quarters].		2008	2423044
[a study of the antineoplastic activity of k18].	k18 is a new drug produced by a combination of melphalan and human immunoglobulin. k18 produced an inhibitory effect on the proliferation of human gastric and colon cancer transplanted in to nude mice. also, combination effects of k18 with mmc and 5-fu were recognized in the same system. in a study of distribution after k18 administration, the accumulation and retention of this drug in the tumor region were observed. in the case of melphalan administration, these phenomena were not observed. the ...	1986	2423038
tumor angiogenesis inhibition by prostaglandin synthetase inhibitors.	the release of prostaglandins from tumor cells seems to play an important role in tumor angiogenesis, in which platelet-derived factors may be also included. administration of prostaglandin synthetase inhibitors reduces the growth of both experimental and human malignant tumors. one explanation may be reduced tumor vascularization, as observed in microangiographic studies of experimental transplantable tumors. a similar effect was observed after induced thrombocytopenia. a number of angiogenesis ...	1986	2423014
in situ assembly states of (na+,k+)-pump atpase in human erythrocytes. radiation target size analyses.	the in situ assembly state of the (na+,k+)-pump atpase of human erythrocytes was studied by applying the classical target theory to radiation inactivation data of the ouabain-sensitive sodium efflux and atp hydrolysis. erythrocytes and their extensively washed white ghosts were irradiated at -45 to -50 degrees c with an increasing dose of 1.5-mev electron beam, and after thawing, the na+-pump flux and/or enzyme activities were assayed. each activity measured was reduced as a simple exponential f ...	1985	2414287
increasing spontaneous language in three autistic children.	a time delay procedure was used to increase spontaneous verbalizations of 3 autistic children. multiple baseline across behaviors designs were used with target responses, selected via a social validation procedure, of two spontaneous responses ("please" and "thank you") and one verbally prompted response ("you're welcome"). the results indicate gains across target behaviors for all children, with occurrence across other stimuli and settings. these gains were validated socially with 10 adults. fu ...	2002	2373659
atypical presentation of chancroid in a patient infected with the human immunodeficiency virus.		1990	2368772
effect of phospholipids on purified lipoamidase.	phospholipids were added to purified lipoamidase from porcine brain microsomal membranes, and changes in lipoamidase activity were examined. approximately twofold activation of lipoamidase activity occurred upon the addition of phosphatidylethanolamine. on the other hand, phosphatidylserine, cardiolipin, and phosphatidic acid reduced the enzyme activity by approximately 80%. this pattern of the activation of lipoamidase by phosphatidylethanolamine and its inhibition by phosphatidylserine is simi ...	1990	2347395
induction of carcinoembryonic-antigen-gene expression in human colorectal carcinoma by sodium butyrate.	the effect of sodium butyrate on the expression of the carcinoembryonic-antigen (cea) gene was studied in two poorly differentiated colorectal-carcinoma cell lines (clone-a and mip-101) and in one well-differentiated cell line (ls-174t); a.t.c.c. no. ccl 188). northern-blot and dot-blot analyses indicated a steady increase in cea mrna from day 4 to a maximal level by day 14 after these cells were exposed to 2 mm-sodium butyrate. studies using nuclear run-off assays followed by dot-blot hybridiza ...	1990	2268282
human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.	tumor necrosis factor alpha (tnf-alpha), in addition to being cytotoxic for certain tumor cells, has turned out as a multifunctional cytokine that is involved in the regulation of immunity and inflammation. since human keratinocytes have been demonstrated to be a potent source of various cytokines, it was investigated whether epidermal cells synthesize and release tnf-alpha. supernatants derived from normal human keratinocytes (hnk) and human epidermoid carcinoma cell lines (kb, a431) were teste ...	1990	2258696
human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.	tumor necrosis factor alpha (tnf-alpha), in addition to being cytotoxic for certain tumor cells, has turned out as a multifunctional cytokine that is involved in the regulation of immunity and inflammation. since human keratinocytes have been demonstrated to be a potent source of various cytokines, it was investigated whether epidermal cells synthesize and release tnf-alpha. supernatants derived from normal human keratinocytes (hnk) and human epidermoid carcinoma cell lines (kb, a431) were teste ...	1990	2258696
induction from a single instance: formation of a novel category.	this study examines whether preschoolers can use information from a known category to induce a characteristic attribute of a novel, contrasting category based on a single instance. we showed 32 four-year-olds three instances of a given category and one instance of a target category. these objects could vary along two attribute dimensions, such as color and shape. all instances of the given category shared identical values of one attribute (e.g., all were blue), but could have different values of ...	2007	2258687
induction from a single instance: formation of a novel category.	this study examines whether preschoolers can use information from a known category to induce a characteristic attribute of a novel, contrasting category based on a single instance. we showed 32 four-year-olds three instances of a given category and one instance of a target category. these objects could vary along two attribute dimensions, such as color and shape. all instances of the given category shared identical values of one attribute (e.g., all were blue), but could have different values of ...	2007	2258687
[cancer diagnosis by oncogenes].		2007	2258662
calcitonin secretion rate in elderly normal subjects.	the aim of the study was to investigate the metabolic clearance rate (mcr) and the secretion rate (sr) of calcitonin (ct) in elderly men and women (mean age +/- se: 75 +/- 3 and 78 +/- 3 yr, respectively). the basal levels of ct were higher in men than in women (9.6 +/- 3.2 vs 6.0 +/- 1.5 pg/ml; p less than 0.05). the mcr was not significantly different between sexes (905 +/- 54.2 vs 810 +/- 165.1 l/day). in contrast, ct sr was significantly higher in male subjects compared to women (8.7 +/- 3.1 ...	2007	2258578
calcitonin secretion rate in elderly normal subjects.	the aim of the study was to investigate the metabolic clearance rate (mcr) and the secretion rate (sr) of calcitonin (ct) in elderly men and women (mean age +/- se: 75 +/- 3 and 78 +/- 3 yr, respectively). the basal levels of ct were higher in men than in women (9.6 +/- 3.2 vs 6.0 +/- 1.5 pg/ml; p less than 0.05). the mcr was not significantly different between sexes (905 +/- 54.2 vs 810 +/- 165.1 l/day). in contrast, ct sr was significantly higher in male subjects compared to women (8.7 +/- 3.1 ...	2007	2258578
prevalence of helicobacter pylori in symptomatic patients undergoing gastrointestinal endoscopy.		1990	2258222
prevalence of helicobacter pylori in symptomatic patients undergoing gastrointestinal endoscopy.		1990	2258222
rolling chair sign.		2007	2241609
tourette's disorder and associated complex behaviors: a case report.	a case of a man with tourette's disorder associated with obsessive-compulsive disorder, multiple sexual paraphilias, and aggressive behavior is described. treatment with haloperidol led to improvement in the characteristic tics of tourette's disorder as well as to improvement in these three complex-associated behaviors. after haloperidol was discontinued, an exacerbation of tics and the associated behaviors occurred.	1990	2238716