| first documented capnocytophaga canimorsus infection in a species other than humans. | capnocytophaga canimorsus was cultured from an infected, dog-inflicted bite wound in a pet rabbit. the wound was treated successfully and the rabbit recovered. to our knowledge, this is the first report of a c. canimorsus infection in a species other than humans. | 2006 | 16904274 |
| association of eubacterium nodatum and treponema denticola with human periodontitis lesions. | the purpose of the present investigation was to compare the levels, proportions and percentage of sites colonized by 40 bacterial species in subgingival plaque samples from periodontally healthy subjects and patients with chronic periodontitis to seek possible pathogens other than the consensus pathogens porphyromonas gingivalis and tannerella forsythia. | 2006 | 16922925 |
| the dangers of dog bites. | this report describes an unusual case of endocarditis caused by capnocytophaga canimorsus as a result of dog bite. the diagnosis could be established only by molecular techniques after amplification of bacterial dna from the infected cardiac valve. the epidemiology and management of capnocytophaga infections is discussed, as well as the role of prophylactic antibiotics in preventing these infections after dog bites. | 2007 | 16943221 |
| microbiota of the dorsum of the tongue after plaque accumulation: an experimental study in humans. | the purpose of the present investigation was to determine the effect of the absence of tongue hygiene on the microbiota of the dorsum of the tongue. | 2006 | 16945032 |
| capnocytophaga canimorsus meningitis after routine myelography: a sentinel event identifies multiple opportunities for improvement of standard practices in radiology. | meningitis developed after a routine myelogram in a healthy patient. when capnocytophaga canimorsus was identified, investigations revealed that the patient, the radiologist, and the staff were all dog owners. multiple deviations from recommended practices in radiology were identified and corrected. the investigation of an unusual sentinel event allowed multiple interventions to be implemented simultaneously, with resultant risk reduction for subsequent radiologic procedures. | 2006 | 17015163 |
| pyogenic arthritis caused by capnocytophaga gingivalis in an immunocompetent three-year-old male. | capnocytophaga gingivalis is most often isolated as normal oral flora or with periodontal disease. this organism is also associated with sepsis usually in immunocompromised hosts. we identified pyogenic arthritis caused by c. gingivalis in a 3-year-old immunocompetent male, whose clinical course closely resembled monoarticular onset pauciarticular juvenile rheumatoid arthritis. this is the first report of c. gingivalis septic arthritis in the world literature, but there are increasing reports of ... | 2001 | 17039147 |
| antimicrobial effect of acidified nitrate and nitrite on six common oral pathogens in vitro. | salivary nitrate is positively correlated with plasma nitrate and its level is 9 times the plasma level after nitrate loading. nitrate in saliva is known to be reduced to nitrite by oral bacteria. nitrate and nitrite levels in saliva are 3 - 5 times those in serum in physiological conditions respectively in our previous study. the biological functions of high salivary nitrate and nitrite are still not well understood. the aim of this in vitro study was to investigate the antimicrobial effects of ... | 2006 | 17134590 |
| brain abscess associated with multidrug-resistant capnocytophaga ochracea infection. | brain abscesses are occasionally associated with a dental source of infection. an unusual case of frontal lobe abscess in a nonimmunocompromised child infected with multidrug-resistant capnocytophaga ochracea is described and confirms the pathogenic potential of this organism to cause human disease in the central nervous system. | 2007 | 17135428 |
| early cystic lung disease in a premature neonate with perinatally acquired capnocytophaga. | we describe a premature infant with early cystic lung lesions and sepsis due to prenatally acquired capnocytophaga infection. early cystic lesions have not been described previously as a characteristic of this infection. | 2007 | 17180135 |
| escape from immune surveillance by capnocytophaga canimorsus. | capnocytophaga canimorsus, a commensal bacterium from dogs' mouths, can cause septicemia or meningitis in humans through bites or scratches. here, we describe and characterize the inflammatory response of human and mouse macrophages on c. canimorsus infection. macrophages infected with 10 different strains failed to release tumor necrosis factor (tnf)- alpha and interleukin (il)-1 alpha . macrophages infected with live and heat-killed (hk) c. canimorsus 5 (cc5), a strain isolated from a patient ... | 2007 | 17205476 |
| a three-year prospective study of adult subjects with gingivitis ii: microbiological parameters. | to investigate whether the clinical benefits obtained with a periodontal prevention programme in subjects with periodontal health or minimal disease were accompanied by beneficial changes in the subgingival microbiota. | 2007 | 17243995 |
| antimicrobial treatment of capnocytophaga infections. | capnocytophaga spp. are normal inhabitants of the oropharyngeal flora. they are also involved in periodontal diseases or animal bites, complicated by septicaemia with dissemination to a great variety of sites, both in immunocompetent and immunocompromised hosts. this review will focus on their pathogenesis, spectrum of clinical infections and susceptibility to disinfectants and antibiotics. the spread of beta-lactamase-producing strains limits the use of beta-lactams as first-line treatments, un ... | 2007 | 17250994 |
| [capnocytophaga]. | | 2007 | 17369972 |
| [septic shock due to capnocytophaga canimorsus]. | | 2007 | 17383144 |
| meningitis caused by capnocytophaga canimorsus: when to expect the unexpected. | in this article we review the available data concerning meningitis caused by capnocytophaga canimorsus. the clinical presentation of this rare condition is described with the emphasis on associated conditions and management issues. two additional cases, illustrating the difficulties in recognizing this rare disease, are presented. reviewing a total of 28 reported cases, a preceding bite-incident by a cat or dog, or close contact with these animals, was described in the majority of cases (89%). p ... | 2007 | 17408852 |
| infection at titanium implants with or without a clinical diagnosis of inflammation. | to assess the microbiota at implants diagnosed with peri-implantitis, implant mucositis, or being clinically healthy. | 2007 | 17517058 |
| odontogenic bacteria in periodontal disease and resistance patterns to common antibiotics used as treatment and prophylaxis in odontology in spain. | resistance in streptococci or gram-negative bacteria is associated with antibiotic consumption. scarce information exists on the antibiotic susceptibility of bacterial isolates from patients with periodontitis in countries with high antibiotic consumption, as this is an area in which microbiological testing is not performed in daily practice. the present study was undertaken to explore the susceptibility of bacterial isolates in periodontitis to antibiotics prescribed in odontology in spain as t ... | 2007 | 17530037 |
| effect of an essential oil-containing antimicrobial mouthrinse on specific plaque bacteria in vivo. | this study was conducted to investigate the effect of rinsing with an essential oil-containing mouthrinse on levels of specific supra and subgingival bacteria in subjects with gingivitis. | 2007 | 17535287 |
| false positive pcr detection of tropheryma whipplei in the saliva of healthy people. | tropheryma whipplei, the agent of whipple's disease (wd), has been recently isolated and the genomes of two isolates have been fully sequenced. previous diagnosis tools for the diagnosis of the disease used sequence analysis of the 16s rrna gene. using this target gene, the high percentage of detection of the bacterium in saliva of healthy people was in contrast to the negative results obtained with specific target genes. the aim of our study was to compare previously published primers targeting ... | 2007 | 17535423 |
| bacterial species in subgingival plaque and oral bone loss in postmenopausal women. | oral bacteria are widely recognized in the etiology of periodontal disease. we investigated the prevalence of subgingival bacterial infection with eight species, tested associations between infection and oral bone loss, and assessed potential confounding factors and effect modifiers of those associations in a large community-based cohort of postmenopausal women. | 2007 | 17539719 |
| [septic shock with purpura fulminans after a dog bite]. | a 61-year-old man presented with a four-day history of back pain and nonspecific abdominal pain. his condition had significantly worsened since the day before admission with generalized weakness and dyspnea. his temperature was 39.1 c, he had tachycardia and was tachypneic. peripheral cyanosis was noted. the abdomen was soft with mild epigastric tenderness. a diffuse skin rash developed with increasing petechial bleeding and central necrosis. it was revealed that he had been bitten by a dog seve ... | 2007 | 17551886 |
| supra-gingival microbiota in sjögren's syndrome. | the aim of this study was to investigate the microbiota of noncaries associated supra-gingival plaque (sgp) microbiology in sjögren's syndrome (ss). stimulated whole saliva (sws) and full-mouth sgp on intact tooth surfaces were collected from 26 primary (p) ss, 27 secondary (s) ss, and 29 control subjects for selective culture of lactobacilli, mutans streptococci, and aerobic and facultatively anaerobic gram-negative rods (agnr). predominant cultivable anaerobes from sgp of 11 randomly selected ... | 2007 | 17609998 |
| leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. a case report and review of the literature. | leukocyte adhesion deficiency type 1 (lad-1) is a rare, inherited immunodeficiency that affects 1 in 1 million people yearly and usually presents with recurrent, indolent bacterial infections of the skin, mouth, and respiratory tract and impaired pus formation and wound healing. features of this disease result from mutations in the region of the cd18 gene, which is encoded on chromosome 21q22.3. this gene codes for the common subunit of the leukocyte integrins lfa-1, mac 1, and p150,95. failure ... | 2008 | 17618138 |
| [a sepsis caused by capnocytophaga canimorsus: diagnostic and therapeutic options]. | the authors present a case report of a patient with sepsis caused by gram negative rod capnocytophaga canimorsus resulting from a dog bite. the infection had a course of septic shock progressing into multiorgan failure and serious ischemic damage to the extremities. the etiologic agent was identified utilizing molecular genetic methods and its detailed microbiologic characteristics are provided below. the report also outlines diagnostic and therapeutic options of this otherwise most likely under ... | 2007 | 17703404 |
| microbiota of plaque microcosm biofilms: effect of three times daily sucrose pulses in different simulated oral environments. | to explore the ecological plaque hypothesis for dental caries. to test modification of the microbiota of dental plaque microcosm biofilms by sucrose pulsing during growth in two different simulated oral fluids, and with a urea-induced plaque ph elevation. | 2007 | 17713343 |
| aortic valve endocarditis by capnocytophaga haemolytica. | we report a case of a 51-year-old patient with suspected prosthetic valve endocarditis. capnocytophaga haemolytica was isolated in blood cultures and the repeated echocardiograms showed growth of vegetations and disruption of the proximal prosthetic valve suture line with progressive aortic regurgitation. the patient underwent a root debridement and replacement with a stentless bioprosthesis. | 2007 | 17720421 |
| corneal ulcers associated with aerosolized crack cocaine use. | we report 4 cases of corneal ulcers associated with drug abuse. the pathogenesis of these ulcers and management of these patients are also reviewed. | 2007 | 17721298 |
| microbiological evaluation of the new vitek 2 neisseria-haemophilus identification card. | vitek 2 is an automated identification system for diverse bacterial and fungal species. a new card (the neisseria-haemophilus [nh] card) for the identification of neisseria spp., haemophilus spp., and other fastidious gram-negative or gram-variable microorganisms has been developed, but its performance in a routine clinical laboratory has not yet been evaluated. in this study, a total of 188 bacterial strains belonging to the genera actinobacillus, campylobacter, capnocytophaga, cardiobacterium, ... | 2007 | 17728469 |
| capnocytophaga cynodegmi peritonitis in a peritoneal dialysis patient. | the first reported case of peritonitis caused by capnocytophaga cynodegmi is presented. the patient was treated with peritoneal dialysis and had contact with a cat. c. cynodegmi is part of the normal oral flora of dogs and cats but is very rarely isolated in clinical specimens from humans. | 2007 | 17881542 |
| case report: vertebral osteomyelitis/discitis as a complication of capnocytophaga canimorsus bacteremia. | a 31-year-old man with a history of congenital ventricular septal defect presented to the emergency department with 3 days of fever and palpitations. four days earlier he sustained a dog bite to the left hand with localized swelling that rapidly resolved without additional signs of infection. no other source of fever was identified on history and physical examination. he was admitted to the hospital for evaluation of the origin of the fever, including possible endocarditis. complete cardiac eval ... | 2008 | 17976760 |
| the bacteriology and antimicrobial susceptibility of infected and non-infected dog bite wounds: fifty cases. | dog bite wounds are a common reason for dogs requiring veterinary care, but there is surprisingly little data on the bacteriology of bite wounds. a prospective study was performed on dogs with various grades of bite wound to identify the bacteria present in these wounds. swabs were collected from all wounds for bacterial culture and cytology. all swabs were cultured aerobically and anaerobically and all aerobic cultures were evaluated for antibiotic susceptibility using the kirby bauer disk diff ... | 2008 | 18029118 |
| [capnocytophaga canimorsus meningitis]. | | 2008 | 18063335 |
| capnocytophaga canimorsus infection with fulminant sepsis in an asplenic patient: diagnosis by review of peripheral blood smear. | | 2008 | 18098127 |
| images in clinical medicine. retiform purpura. | | 2008 | 18184954 |
| diversity of capnocytophaga species in children and description of capnocytophaga leadbetteri sp. nov. and capnocytophaga genospecies ahn8471. | bacteria of the genus capnocytophaga form part of the resident oral flora in children and adults. they are recognized as opportunistic pathogens of various extra-oral infections. the significance of individual species in periodontal and extra-oral diseases is unclear, due to the inability of conventional phenotypic tests to identify clinical isolates to species level. aiming at a clear distinction between species, we undertook a phylogenetic study of a collection of 102 capnocytophaga strains in ... | 2008 | 18218926 |
| clinical and microbiological analysis of subjects treated with brånemark or astratech implants: a 7-year follow-up study. | to assess the impact of different implant systems on the clinical conditions and the microbiota at implants, and whether the presence of bacteria at tooth sites was predictive of the presence at implant sites. | 2008 | 18261121 |
| colonization pattern of periodontal bacteria in japanese children and their mothers. | the purpose of this study was to determine the time of infection by anaerobic gram-negative rods associated with periodontal disease, and to clarify their transmission from mother to child. | 2008 | 18302616 |
| capnocytophaga spp. df-1 pneumonia in an immune-competent 56-year old man post-cabg. | we report a case of a nosocomial capnocytophaga spp. df-1 pneumonia in an intubated 56-year-old man following coronary artery bypass grafting. we review capnocytophaga spp., including the infections they produce and antibiotic susceptibilities. | 2008 | 18343755 |
| a case of capnocytophaga canimorsus brain abscess secondary to dog's bite. | capnocytophaga canimorsus has been recognized as an opportunistic pathogen causing systemic infections in immunocompromised individuals. it is part of the normal oral flora of the dog, and can be responsible for localized wound infections in humans in consequence of bites. this microorganism causes also septicemia, meningitis, endocarditis, ocular infections and rarely brain abscess. we describe the case of an immunocompetent 28-year-old male with temporal brain abscess from capnocytophaga canim ... | 2008 | 18366884 |
| [septicaemia with capnocytophaga sputigena in a newborn child]. | we describe in this article a case of septicaemia with capnocytophaga suptigena in a premature newborn child. the newborn child exhibited fever at birth, a light inflammatory syndrome and a respiratory failure. the germ was initially identified in the blood-culture of the newborn child by conventional techniques, and then confirmed by sequencing of the arn 16s. after investigation, it was also found in the mother's vaginal sample. capnocytophaga sputigena carried by the mother is certainly respo ... | 2008 | 18390433 |
| [microbiological and biochemical characteristics of inflammatory tissues in the periodontium]. | to investigate bacterial populations in subgingival and supragingival plaque samples of patients with inflammatory periodontal diseases and activities of the lysosomal enzymes--lysozyme, alkaline phosphatase, and beta-glucuronidase--in peripheral venous blood, in gingival crevicular fluid, and mixed nonstimulated saliva. | 2008 | 18413987 |
| microbiological evaluation of primary endodontic infections in teeth with and without sinus tract. | to examine the microbiological status of primary endodontic infections in teeth with and without a sinus tract. | 2008 | 18422583 |
| diverse and novel oral bacterial species in blood following dental procedures. | we identified oral bacterial species in blood cultures following single-tooth extraction and tooth brushing. sequence analysis of 16s rrna genes identified 98 different bacterial species recovered from 151 bacteremic subjects. of interest, 48 of the isolates represented 19 novel species of prevotella, fusobacterium, streptococcus, actinomyces, capnocytophaga, selenomonas, and veillonella. | 2008 | 18434561 |
| photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. | recent preclinical and clinical data have suggested the potential benefit of photodynamic therapy (pdt) in the treatment of periodontitis. however, currently, there are very limited data from controlled clinical trials evaluating the effect of pdt in the treatment of periodontitis. the aim of the present study was to evaluate the clinical and microbiological effects of the adjunctive use of pdt in non-surgical periodontal treatment in patients receiving supportive periodontal therapy. twenty-fou ... | 2009 | 18465191 |
| caries-related plaque microcosm biofilms developed in microplates. | in vivo dental plaque biofilms consist of complex communities of oral bacteria that are a challenge to replicate in vitro. the aim of this investigation was to establish human dental plaque microcosms in microplates to reflect conditions that are relevant to dental caries. microcosm plaque biofilms were initiated from the saliva of two different donors, grown for up to 10 days in 24-welled microplates on thermanox coverslips in various types of artificial saliva with and without sucrose, which w ... | 2007 | 17311629 |
| epiglottitis and necrotizing fasciitis: a life-threatening complication of infectious mononucleosis. | life-threatening cervical complications associated with infectious mononucleosis are rare. the combination of acute epiglottitis and subsequent necrotizing fasciitis of the head and neck in a patient with infectious mononucleosis has not been reported to date.a 47-year-old female with infectious mononucleosis and epiglottitis was admitted to hospital for i.v. therapy. owing to her poor clinical condition and the spread of the infection to the throat and superior mediastinum, as evidenced by ct, ... | 2005 | 16298800 |
| intra-amniotic infection caused by capnocytophaga species. | capnocytophaga species are common oral pathogens and infrequent causes of systemic infection in patients with compromised host. the isolation of this organism suggests an oral source of infection. | 1996 | 18476112 |
| assessment of the microbiota in root canals of human primary teeth by checkerboard dna-dna hybridization. | the purpose of this study was to evaluate in vivo the prevalence of microorganisms in root canals of human primary teeth, by checkerboard dna-dna hybridization. | 2007 | 18477431 |
| removal and prevention of dental plaque with d-tagatose. | dental plaque develops when early bacterial colonizers adhere to the acquired pellicle (saliva-derived proteinous coating on the tooth surface) followed by adhesion of late interspecies colonizers to form this type of biofilm (coaggregation). in developing a d-tagatose-based toothpaste, we examined 15 oral isolates, including both early colonizers (streptococcus and actinomyces) and late colonizers (fusobacterium, porphyromonas, prevotella, veillonella, capnocytophaga, and actinobacillus), and t ... | 2002 | 18498514 |
| first case of bacteremia due to chromosome-encoded cfxa3-beta-lactamase-producing capnocytophaga sputigena in a pediatric patient with acute erythroblastic leukemia. | bacteremia due to capnocytophaga sputigena occurred in a 4-year and 9-month-old japanese girl patient with acute erythroblastic leukemia in shinshu university hospital, japan. on her admission to the hospital, she had a temperature of 38.2 degrees c with canker sore. prior to the commencement of chemotherapy, peripheral blood culture was carried out with the bact/alert 3d system ver. 4.00d (biomerieux japan ltd., tokyo, japan) using both the pf and the sn bottles. at 48 hrs of incubation, the sy ... | 2008 | 18499560 |
| [capnocytophaga canimorsus sepsis after a dog bite]. | a 63-year-old man was admitted to hospital. he had a history of splenectomy secondary to trauma, previous alcohol abuse, cirrhosis and oesophagus varices. the patient had been bitten by a dog three days before admittance. he rapidly developed disseminated intravascular coagulation and multiple organ dysfunction. six days after the bite, the patient died despite antibiotic treatment. the gram-negative rod capnocytophaga canimorsus was found in the blood culture. this case emphasizes the importanc ... | 2008 | 18513481 |
| influence of previous antimicrobial therapy on oral carriage of beta-lactamase producing capnocytophaga isolates. | in order to assess the prevalence of beta-lactamase producing oral bacteria in childhood, the influence of different parameters on the oral carriage of capnocytophaga was studied in a specific population of children with cancer. the examined parameters included clinical observation of oropharyngeal mucosa, type of malignant disease and intake of chemotherapy and antimicrobial treatment. | 2008 | 18532936 |
| capnocytophaga canimorsus: infection, septicaemia, recovery and reconstruction. | a case is presented of a life-threatening septicaemia and associated peripheral necrosing microembolic phenomenon, resulting from a dog lick to an insignificant burn wound. the isolated bacterium was capnocytophaga canimorsus, a slow-growing gram-negative bacillus commonly found in dog saliva. any clinician seeing patients with a history of dog bite/saliva contact and progressive illness should consider this bacterium as a possible offender and take special care to elicit an accurate history, sp ... | 2008 | 18566152 |
| acute onset of fever, chills, and lethargy in a 36-year-old woman. | | 2008 | 18574296 |
| comparative analysis of endodontic pathogens using checkerboard hybridization in relation to culture. | the purpose of this study was to detect bacterial species and to quantify the total number of bacteria from samples of infected root canals before (s1) and after chemo-mechanical preparation using 2% chlorhexidine (chx) gel as auxiliary chemical substance (s2) and after 7 days of intracanal dressing (s3) to compare microbial changes. | 2008 | 18582327 |
| terminal restriction fragment length polymorphism analysis of the microflora in necrotic teeth of patients irradiated in the head and neck region. | this study evaluated the microflora in root canals of necrotic teeth after radiotherapy of the head and neck region. the microbial composition of samples taken from necrotic root canals in patients treated with irradiation of the head and neck (group a, n = 13) and in healthy controls (group b, n = 11) was analyzed by terminal restriction fragment-length polymorphism (t-rflp) analysis. a total of 50 different terminal restriction fragment lengths (t-rfs) (each representing one or more bacterial ... | 2008 | 18718363 |
| a 52-year-old man with malaise and a petechial rash. | background: capnocytophaga canimorsus is a gram-negative, fusiform, rod-shaped organism that is part of the normal oral flora of dogs, cats, and other animals. a significant number of emergency department (ed) patients are surgically or functionally asplenic and may be at marked risk for overwhelming post-splenectomy infection (opsi). opsi has a mortality rate estimated to be up to 70%. the risk of sepsis is estimated to be 30-60 times greater after splenectomy, and c. canimorsus is one of the o ... | 2008 | 18722741 |
| genetic tools for studying capnocytophaga canimorsus. | capnocytophaga canimorsus, a commensal bacterium from canine oral flora, has been isolated throughout the world from severe human infections caused by dog bites. due to the low level of evolutionary relationship to proteobacteria, genetic methods suitable for the genus capnocytophaga needed to be established. here, we show that tn4351, derived from bacteroides fragilis, could be introduced by conjugation into c. canimorsus and conferred resistance to erythromycin. by mapping and sequencing a nat ... | 2008 | 18723653 |
| capnocytophaga cynodegmi in a rottweiler dog with severe bronchitis and foreign-body pneumonia. | capnocytophaga cynodegmi is a zoonotic, gram-negative, capnophilic bacterium that is usually seen in people with infections associated with dog or cat bites. the first reported case of c. cynodegmi infection in a dog is described here. | 2008 | 18753348 |
| photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. | recent preclinical and clinical data have suggested a potential benefit of photodynamic therapy (pdt) in the treatment of periodontitis. however, there are very limited data from controlled clinical trials evaluating the effect of pdt in the treatment of periodontitis. the aim of this study was to evaluate the clinical and microbiologic effects of the adjunctive use of pdt to non-surgical periodontal treatment. | 2008 | 18771363 |
| [fatal case of sepsis with capnocytophaga canimorsus after a minor dog bite]. | a healthy 54-year-old man presented at the emergency department with signs of sepsis. four days prior he was bitten and scratched by his dog. microscopy of the blood smear showed intracellular gram-negative rods. despite maximal treatment the patient died a day and a half after admission due to septic shock with multi-organ failure and disseminated intravascular coagulopathy. after extended incubation of the spleen culture a gram-negative rod was isolated and identified as capnocytophaga canimor ... | 2008 | 18788680 |
| [capnocytophaga sputigena pleuropneumonitis: a case report]. | community-acquired pneumonia is complicated by purulent pleural effusion in approximately 28% of affected children. its incidence has increased over the last decade. streptococcus pneumoniae is the most frequent causal microorganism, encountered in roughly 80% of cases. we report the case of an immunocompetent 13-year-old teenager wearing orthodontic braces who suffered from pleuropneumonia due to capnocytophaga sputigena. to date, this gram-negative bacillus, a commensal of the buccal cavity, h ... | 2008 | 18804973 |
| capnocytophaga canimorsus: a human pathogen feeding at the surface of epithelial cells and phagocytes. | capnocytophaga canimorsus, a commensal bacterium of the canine oral flora, has been repeatedly isolated since 1976 from severe human infections transmitted by dog bites. here, we show that c. canimorsus exhibits robust growth when it is in direct contact with mammalian cells, including phagocytes. this property was found to be dependent on a surface-exposed sialidase allowing c. canimorsus to utilize internal aminosugars of glycan chains from host cell glycoproteins. although sialidase probably ... | 2008 | 18818736 |
| acute tenosynovitis of the ankle due to capnocytophaga cynodegmi/canimorsus as identified by 16s rrna gene sequencing. | | 2008 | 18819833 |
| cerebral abscess caused by capnocytophaga spp in an immunocompetent subject: case report. | capnocytophaga spp are gram-negative bacteria commonly identified as oral saprophytes of humans, dogs and cats; they rarely cause invasive infections in immunocompetent subjects. this case report is about a rare case of cerebral abscess caused by capnocytophaga spp in an immunocompetent subject who had no risk factors for capnocytophaga invasive infections (oral alterations, traumatic or iatrogenic lesions of pharynx and/or oesophagus, recent dog bite). we also report capnocytophaga spp naturall ... | 2008 | 18843215 |
| capnocytophaga canimorsus resists phagocytosis by macrophages and blocks the ability of macrophages to kill other bacteria. | capnocytophaga canimorsus is a commensal bacterium from the canine oral flora, which can cause septicemia or meningitis in humans upon bite wound infections. c. canimorsus 5 (cc5), a strain isolated from a patient with fatal septicemia, was used to investigate the interaction between c. canimorsus and j774.1 mouse macrophages. j774.1 cells infected at high multiplicity with cc5 did not phagocytose nor kill cc5 within 120 min of infection, unless the bacteria were opsonized with specific antibodi ... | 2008 | 18926295 |
| capnocytophaga canimorsus endogenous endophthalmitis in an immunocompetent host. | | 2008 | 18952664 |
| factors affecting human supragingival biofilm composition. ii. tooth position. | little is known regarding the factors that affect the microbial composition of supragingival biofilms. this study was designed to test the hypothesis that tooth location affects the microbial composition of supragingival plaque beyond the effect due to plaque mass as reflected by total dna probe count. | 2009 | 18973539 |
| factors affecting human supragingival biofilm composition. i. plaque mass. | little is known about the factors that affect the microbial composition of supragingival biofilms. this study was designed to examine the relationship between total dna probe counts of supragingival biofilm samples, clinical parameters and supragingival biofilm composition. | 2009 | 18973540 |
| [animal bites and infection]. | animal bites, mostly dog bites, often require an emergency department visit, but are often mistakenly considered innocuous. indeed, bite wounds can lead to an handicap as well as become infected, mostly with the oral flora of the biting animal (pasteurella, capnocytophaga, eikennella, streptococci, staphylococci and anaerobic bacteria). bites can also cause other infections like tetanus, rabies, cat scratch disease, tularemia, leptospirosis, rat-bite fever and plague. the management of bite woun ... | 2008 | 19009844 |
| microbiological findings in subjects with asymptomatic oral lichen planus: a cross-sectional comparative study. | the bacterial colonization of the oral mucosa was evaluated in patients with asymptomatic oral lichen planus (olp) and compared to the microbiologic status in mucosally healthy subjects. | 2008 | 19053926 |
| a patient with bacteraemia and possible endocarditis caused by a recently-discovered genomospecies of capnocytophaga: capnocytophaga genomospecies ahn8471: a case report. | capnocytophaga are a genus of bacteria that have been found to be the causative organisms in a range of infections, including serious conditions such as bacteraemia, endocarditis and meningitis. this has been especially true amongst those with serious comorbidities and the immunocompromised populations. although several species are known to cause human disease, historically, laboratories have often not identified isolates to species level due to the unreliable, laborious techniques needed. with ... | 2008 | 19055815 |
| capnocytophaga canimorsus a novel pathogen for joint arthroplasty. | we report the case of a 59-year-old man with waldenstrom's macroglobulinemia and active alcohol use who presented with bilateral knee pain 5 years after a bilateral staged tka. cultures of synovial fluid and periprosthetic tissue specimens from both knees yielded, after prolonged anaerobic incubation, a catalase- and oxidase-positive gram-negative bacillus, which was identified as capnocytophaga canimorsus by 16s ribosomal rna pcr analysis. c. canimorsus, an organism that is commonly found in do ... | 2009 | 19067091 |
| a 42-year-old woman with septic shock: an unexpected source. | background: dog bites are the most common animal bite injuries occurring in the united states. estimated infection rates range between 15% and 20%. polymicrobial infections are most common. capnocytophaga canimorsus (c. canimorsus) is a gram-negative rod strongly associated with dog bites, and is known to cause life-threatening infection in humans. objectives: 1) outline epidemiology of dog bites in the united states; 2) identify host factors associated with infection, and common pathogens; 3) d ... | 2009 | 19201139 |
| community-acquired capnocytophaga canimorsus meningitis in adults: report of one case with a subacute course and deafness, and literature review. | an adult with community-acquired capnocytophaga canimorsus meningitis presented with a subacute course, deafness, and a predominantly lymphocytic csf cell count. | 2009 | 19218001 |
| does pregnancy have an impact on the subgingival microbiota? | we investigated clinical and subgingival microbiologic changes during pregnancy in 20 consecutive pregnant women > or =18 years not receiving dental care. | 2009 | 19228092 |
| capnocytophaga canimorsus. | capnocytophaga canimorsus is a commensal bacterium in the oral flora of dogs and cats. the bacterium is a zoonotic agent and has been isolated from humans, infected by dog or cat bites, scratches, licks or simply exposure to dogs or cats. here the infectious agent, its pathogenicity and potential virulence factors, infection in animals and humans, diagnostic methods, prevalence, therapy and prevention are described. suggestions for future research are given. | 2010 | 19268498 |
| community-acquired bacterial meningitis in elderly patients: experience over 30 years. | clinical characteristics, etiologies, evolution, and prognostic factors of community-acquired bacterial meningitis in elderly patients are not well known. to improve this knowledge, all episodes of community-acquired bacterial meningitis were prospectively recorded and cases occurring in patients >or=65 years old were selected. during the period 1977-2006, 675 episodes in adults (aged >or=18 yr) were recorded, with 185 (27%) in patients aged >or=65 years old; 76 were male and 109 were female, wi ... | 2009 | 19282702 |
| prevalence of capnocytophaga canimorsus in dogs and occurrence of potential virulence factors. | capnocytophaga canimorsus is a gram-negative commensal of dog's mouth causing severe human infections. a strain isolated from a human fatal infection was recently shown to have a sialidase, to inhibit the bactericidal activity of macrophages and to block the release of nitric oxide by lps-stimulated macrophages. the present study aimed at determining the prevalence of c. canimorsus in dogs and the occurrence of these hypothetical virulence factors. c. canimorsus could be retrieved from the saliv ... | 2009 | 19285152 |
| resistance of capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes. | capnocytophaga canimorsus is a bacterium of the canine oral flora known since 1976 to cause rare but severe septicemia and peripheral gangrene in patients that have been in contact with a dog. it was recently shown that these bacteria do not elicit an inflammatory response (h. shin, m. mally, m. kuhn, c. paroz, and g. r. cornelis, j. infect. dis. 195:375-386, 2007). here, we analyze their sensitivity to the innate immune system. bacteria from the archetype strain cc5 were highly resistant to kil ... | 2009 | 19307219 |
| man's best friend? infective endocarditis due to capnocytophaga canimorsus. | infective endocarditis caused by zoonotic microorganisms is an uncommon clinical entity. a 55-year-old man was diagnosed with endocarditis due to capnocytophaga canimorsus, a commensal bacterium contained in the saliva of dogs, that involved the aortic and tricuspid valves and was complicated by a para-aortic valve abscess and aorta-to-right atrial fistula. the patient was successfully treated with antibiotic therapy and surgical intervention. c canimorsus endocarditis should be considered in pa ... | 2009 | 19340358 |
| are putative periodontal pathogens reliable diagnostic markers? | periodontitis is one of the most common chronic inflammatory diseases. a number of putative bacterial pathogens have been associated with the disease and are used as diagnostic markers. in the present study, we compared the prevalence of oral bacterial species in the subgingival biofilm of generalized aggressive periodontitis (gap) (n = 44) and chronic periodontitis (cp) (n = 46) patients with that of a periodontitis-resistant control group (pr) (n = 21). the control group consisted of subjects ... | 2009 | 19386852 |
| the impact of the stone age diet on gingival conditions in the absence of oral hygiene. | the objective of this study was to assess the oral microbiota and clinical data in subjects without access to traditional oral hygiene methods and who ate a diet available in the stone age. | 2009 | 19405829 |
| bite-related and septic syndromes caused by cats and dogs. | bite infections can contain a mix of anaerobes and aerobes from the patient's skin and the animal's oral cavity, including species of pasteurella, streptococcus, fusobacterium, and capnocytophaga. domestic cat and dog bite wounds can produce substantial morbidity and often require specialised care techniques and specific antibiotic therapy. bite wounds can be complicated by sepsis. disseminated infections, particularly those caused by capnocytophaga canimorsus and pasteurella multocida, can lead ... | 2009 | 19555903 |
| comparison between polymerase chain reaction-based and checkerboard dna hybridization techniques for microbial assessment of subgingival plaque samples. | to compare polymerase chain reaction (pcr) with subsequent reverse hybridization (micro-ident test) and checkerboard dna-dna hybridization for the identification of 13 bacterial species in subgingival plaque samples. | 2009 | 19563330 |
| bilateral endophthalmitis due to dog bite. | | 2009 | 19576511 |
| molecular characterization of capnocytophaga canimorsus and other canine capnocytophaga spp. and assessment by pcr of their frequencies in dogs. | capnocytophaga canimorsus can be a virulent pathogen, whereas c. cynodegmi is of low virulence. heterogeneity within these species, their frequency in dogs, and pathogenicity factors are largely unknown. strains from blood cultures from patients presumptively identified as c. canimorsus (n = 25) and as c. cynodegmi by rrs analysis (n = 4), blood cultures from dogs (n = 8), blood cultures from cats (n = 2), and cultures from swabs from dog mouths (n = 53) were analyzed. pcr-restriction fragment l ... | 2009 | 19641058 |
| management of human and animal bite wound infection: an overview. | animal and human bite wounds can lead to serious infections. the organisms recovered generally originate from the biter's oral cavity and the victim's skin flora. anaerobes were isolated from more than two thirds of human and animal bite infections. streptococcus pyogenes is often recovered in human bites, pasteurella multocida in animal bites, eikenella corrodens in animal and human, capnocytophaga spp, neisseria weaveri, weeksella zoohelcum, neisseria canis, staphylococcus intermedius, nonoxid ... | 2009 | 19698283 |
| assessment of intraradicular bacterial composition by terminal restriction fragment length polymorphism analysis. | the aim of the study was to assess the bacterial community structures associated with endodontic infections using terminal restriction fragment length polymorphism (t-rflp), and to investigate the correlation of whole community profiles with the manifestation of particular clinical features. | 2009 | 19702949 |
| woman's best friend? | dog bites are commonly thought to be less infectious than similar injuries from other domestic or wild animals. many people who are bitten by a dog treat themselves at home or go to a medical site to have their wounds simply "cleaned and watched." this report describes a serious delayed consequence of a dog bite that was missed by common bacteriological testing. | 2009 | 19708313 |
| comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. | this study compared the subgingival microbiota of subjects with refractory periodontitis (rp) to those in subjects with treatable periodontitis (grs = good responders) or periodontal health (ph) using the human oral microbe identification microarray (homim). | 2009 | 19722792 |
| distribution of periodontopathic bacterial species in japanese children with developmental disabilities. | recent developments in molecular biological techniques have enabled rapid detection of periodontopathic bacterial species in clinical specimens. accumulated evidence suggests that detection of specific bacterial species enables identification of subjects at high risk for the onset of periodontitis. we investigated the distribution of 10 selected periodontopathic bacterial species in dental plaque specimens obtained from children with disabilities who were attending daycare centers. | 2009 | 19772671 |
| [a case of empyema due to capnocytophaga sp. and actinomyces israelii]. | a 54-year-old man was admitted to our hospital for investigation of cough, sputum production, and fever of 1 month's duration. his diabetes mellitus was poorly controlled, and his hemoglobin hba1c value was elevated at 10.9%. chest x-ray film and computed tomography scan showed bilateral but predominantly right-sided pleural effusion. aspiration of the pleural fluid from the right-side showed frank pus, and empyema was diagnosed. capnocytophaga sp. and actinomyces israelii were isolated in the p ... | 2009 | 19882914 |
| changes in the incidence of periodontal pathogens during long-term monitoring and after application of antibacterial drugs. | the incidence of potential periodontal pathogens (aggregatibacter actinomycetemcomitans, formerly actinobacillus actinomycetemcomitans, tannerella forsythia, porphyromonas gingivalis, prevotella nigrescens, prevotella intermedia and capnocytophaga ochracea) was monitored in patients with chronic periodontitis and in healthy control subjects. two types of studies were carried out in which the composition of the bacterial communities in different niches of the same oral cavity ecosystem was invest ... | 2009 | 19937216 |
| defining the healthy "core microbiome" of oral microbial communities. | most studies examining the commensal human oral microbiome are focused on disease or are limited in methodology. in order to diagnose and treat diseases at an early and reversible stage an in-depth definition of health is indispensible. the aim of this study therefore was to define the healthy oral microbiome using recent advances in sequencing technology (454 pyrosequencing). | 2009 | 20003481 |
| [an autopsy case involving severe sepsis due to capnocytophaga canimorsus infection]. | capnocytophaga canimorsus, a commensal bacterium from the carine mouth, causes septicemia in human beings through bites or scratches. we report a case of a 60-year-old man contracting septicemia due to c. canimorsus infection after a dog bite who died less than 12 hours after admission. we observed neutrophils with intracytoplasmic bacilli in the peripheral blood smear. we discuss clinical presentation and autopsy findings. | 2009 | 20034321 |
| capnocytophaga species and preterm birth: case series and review of the literature. | capnocytophaga, a genus of gram-negative anaerobes that inhabit the oral cavity, has been reported to be an unusual cause of chorioamnionitis and neonatal infection. we report five cases of capnocytophaga spp. infections in preterm infants (one proven infection and four probable infections) and review 14 previously reported cases. we suggest that capnocytophaga sp. may be responsible for some occult causes of chorioamnionitis or preterm birth, and that the prevalence of this infection may be hig ... | 2010 | 20041890 |
| in vitro killing activity of crevicular concentrations of tinidazole plus common oral antibiotics against high-density mixed inocula of periodontal pathogens in strict anaerobic conditions. | odontogenic infections are polymicrobial. this study explores the in vitro killing activity by concentrations similar to those found in crevicular fluid of tinidazole in combination with amoxicillin/clavulanic acid, clindamycin and levofloxacin against four groups of high-density mixed inocula of anaerobes (prevotella buccae, fusobacterium nucleatum, and veillonella spp.) and facultative (capnocytophaga spp. and streptococcus spp.) isolates of periodontal pathogens. | 2010 | 20059425 |
| [meningitis following a dog bite]. | | 2010 | 20106553 |
| effect of herbal, essential oil, and chlorhexidine mouthrinses on the composition of the subgingival microbiota and clinical periodontal parameters. | the purpose of the present investigation was to determine if antimicrobial mouthrinses with different formulations could affect the composition of the subgingival microbiota and clinical parameters of adjacent tissues in periodontal maintenance subjects. | 2009 | 20128317 |