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therapeutic drug monitoring. 20102863512
acute humoral rejection of an abo-unmatched liver allograft in a pediatric recipient.acute humorally mediated rejection of organ allografts has long been recognized in kidney transplantation as the syndrome of hyperacute rejection. this reaction precludes renal transplantation across the major blood-group system and in many other instances in which preformed antibodies are present in the host. there is increasing evidence of the importance of humoral rejection in graft survival following liver transplantation. although the antibodies responsible for this process have seldom been ...20103067237
[prognosis of obstetrical hemorrhages in multiparous women]. 20102955711
proton beam therapy of uveal melanomas. 20103006647
proton beam therapy of uveal melanomas. 20103006647
a virulent wolbachia infection decreases the viability of the dengue vector aedes aegypti during periods of embryonic quiescence.a new approach for dengue control has been proposed that relies on life-shortening strains of the obligate intracellular bacterium wolbachia pipientis to modify mosquito population age structure and reduce pathogen transmission. previously we reported the stable transinfection of the major dengue vector aedes aegypti with a life-shortening wolbachia strain (wmelpop-cla) from the vinegar fly drosophila melanogaster. here, we report a further characterization of the phenotypic effects of this viru ...201020644622
wolbachia pipientis: an expanding bag of tricks to explore for disease control.wolbachia pipientis are maternally inherited, endosymbiotic bacteria that are widespread among insects. two recent studies have demonstrated that wolbachia inhibits the ability of medically significant pathogens, including filarial nematodes, dengue virus and plasmodium to form infections in the mosquito vector, aedes aegypti. we highlight the added value of these traits for wolbachia based biocontrol strategies and evaluate the evidence for the idea that the insect immune response is responsibl ...201020647151
the native wolbachia endosymbionts of drosophila melanogaster and culex quinquefasciatus increase host resistance to west nile virus infection.the bacterial endosymbiont wolbachia pipientis has been shown to increase host resistance to viral infection in native drosophila hosts and in the normally wolbachia-free heterologous host aedes aegypti when infected by wolbachia from drosophila melanogaster or aedes albopictus. wolbachia infection has not yet been demonstrated to increase viral resistance in a native wolbachia-mosquito host system.201020700535
cyclosporin a treatment in children with minimal change nephrotic syndrome and focal segmental glomerulosclerosis.in a pilot study 23 children with nephrotic syndrome were treated with cyclosporin a (cs) for 6-45 months. 8 children suffered from steroid dependent minimal change nephrotic syndrome (mcns) and had experienced at least one course with cytotoxic drugs, but had relapsed thereafter. 2 children had diabetes mellitus type i with nephrotic syndrome and 13 children had steroid resistant focal segmental glomerulosclerosis (fsgs). cs was started with 100 mg/m2/day in two doses and increased stepwise to ...20113236762
tripelennamine enhances buprenorphine-, but not pentazocine-induced hyperactivity in mice.the opioid agonist-antagonist pentazocine (1-30 mg/kg) and the partial agonist buprenorphine (0.05-0.25 mg/kg) were tested, alone or in combination with the histamine h1-receptor antagonist tripelennamine (1, 2.5, 5 or 10 mg/kg), on locomotor activity in mice of the cd-1 strain. when given alone, pentazocine produced slight and non-dose-related activity increments, while buprenorphine induced strong and dose-related locomotor stimulation. tripelennamine slightly increased activity by itself and ...20113137594
genetic and cytogenetic analysis of the american cherry fruit fly, rhagoletis cingulata (diptera: tephritidae).the american eastern cherry fruit fly, rhagoletis cingulata, a pest of cherries in the western hemisphere, invaded europe in 1983, and since then dispersed to several european countries. information on the genetics and cytogenetics of this pest is very scarce. the mitotic karyotype and detailed photographic maps of the salivary gland polytene chromosomes of r. cingulata are presented here. the mitotic metaphase complement consists of six pairs of chromosomes with the sex chromosomes being very s ...201122447527
wolbachia as an "infectious" extrinsic factor manipulating host signaling pathways.wolbachia pipientis is a widespread endosymbiont of filarial nematodes and arthropods. while in worms the symbiosis is obligate, in arthropods wolbachia induces several reproductive manipulations (i.e., cytoplasmic incompatibility, parthenogenesis, feminization of genetic males, and male-killing) in order to increase the number of infected females. these various phenotypic effects may be linked to differences in host physiology, and in particular to endocrine-related processes governing growth, ...201122654845
a retrospective analysis of a consecutive series of patients splenectomized for various hematologic disorders.at our hospital, 47 out of 184 consecutive splenectomies performed over 7 recent years were carried out on patients afflicted with various hematologic diseases. the results of these 47 splenectomies were the subject of a careful retrospective analysis. the majority of the splenectomies (81%) were therapeutic. cytopenia, particularly thrombocytopenia, was the most common indication for surgery. as a whole, good therapeutic responses with rapid improvements in peripheral blood picture and/or dimin ...20113107320
dirofilaria immitis and wolbachia pipientis: a thorough investigation of the symbiosis responsible for canine heartworm disease.canine heartworm disease wreaks havoc inside canines all throughout the modern world, including the usa. any region where mosquitoes thrive will provide efficient dog-to-dog transportation for the microfilaria of the infectious nematode dirofilaria immitis. veterinary scientists have recently discovered both phylogenetic and biochemical evidence for the obligate symbiosis of d. immitis and the bacteria wolbachia pipientis. as a result, veterinarians have initiated testing of antibiotic therapies ...201121922235
high prevalence and lack of diversity of wolbachia pipientis in aedes albopictus populations from northeast brazil.the use of wolbachia as a tool to control insect vectors has recently been suggested. in this context, studies on the prevalence and diversity of this bacterium in wild populations are relevant. here, we evaluated the diversity of two wolbachiagenes (ftsz and wsp) and the prevalence of this endosymbiont in wild aedes albopictus. using semi-nested polymerase chain reaction, our results showed that 99.3% of the individuals were superinfected with wolbachia. in regards to genetic diversity, the two ...201122012236
the bacteriophage woric is the active phage element in wri of drosophila simulans and represents a conserved class of wo phages.the alphaproteobacterium wolbachia pipientis, the most common endosymbiont in eukaryotes, is found predominantly in insects including many drosophila species. although wolbachia is primarily vertically transmitted, analysis of its genome provides evidence for frequent horizontal transfer, extensive recombination and numerous mobile genetic elements. the genome sequence of wolbachia in drosophila simulans riverside (wri) is available along with the integrated bacteriophages, enabling a detailed e ...201122085419
bilateral pelvic lymphadenectomy and radical retropubic prostatectomy for stage c or d1 adenocarcinoma of the prostate: possible beneficial effect of adjuvant treatment.limited clinical stage c (t3 nx m0) disease can be treated surgically, and morbidity can be acceptable. when appropriate adjuvant therapy (orchiectomy and/or radiation) is administered, residual cancer can be controlled locally for at least a limited period. the incidence of local progression in pathologic stage c or d1 disease may be negligible after early adjuvant orchiectomy and/or radiation treatment. the combination of immediate orchiectomy and radical prostatectomy has been shown to limit ...20113173496
the costs of crime and the benefits of drug abuse treatment: a cost-benefit analysis using tops data. 20113140032
ovarian carcinoma: abdominopelvic irradiation following reexploration.twenty patients with ovarian cancer, who following reexploration were left with residual disease nodules of less than 2 cm diameter, received abdominopelvic irradiation. of these patients 18 had previous chemotherapy. fifteen patients completed treatment, 13 of whom had prior chemotherapy. six of the 18 patients with invasive tumors were alive and disease free 18-53 months postradiotherapy, while only 4 patients had died at the time of follow-up. no patient with residual nodules greater than 1 c ...20113141249
syto11 staining vs fish staining: a comparison of two methods to stain wolbachia pipientis in cell cultures.the aedes albopictus c7-10 cell line was infected with wolbachia strains wri and walbb to create c7-10r and c7-10b cell lines, respectively. we compared two different methods, fluorescence in situ hybridization staining and syto11 staining, to describe these new wolbachia infections in c7-10.201121214605
variable infection frequency and high diversity of multiple strains of wolbachia pipientis in perkinsiella planthoppers.this survey of wolbachia infections in populations of the planthoppers perkinsiella saccharicida and perkinsiella vitiensis revealed variable frequencies, low-titer infections, and high phylogenetic diversities of strains. these observations add to the growing realization that wolbachia infections may be extremely common within invertebrates and yet occur infrequently within populations and at low titer within individuals.201121278277
nursing's role in promoting health for elders in the community. 20113071500
characterization of an intergenic polymorphic site (pp-hc1a_5) in wolbachia pipientis (wpip).wolbachia pipientis (wpip) is an intracellular bacterium causing cytoplasmic incompatibility in arthropods, including mosquitoes of the culex pipiens complex. here, we present a method useful for genotyping within the wpip group. primers were designed using a tandem repeat finder program to amplify an intergenic, polymorphic site (pp-hc1a_5) of wpip. the polymorphic site is located between genes that code for polynucleotide phosphorylase and a hypothetical protein (c1a_5). comparison of these wp ...201121676204
a new species of litomosoides (nematoda: onchocercidae), parasite of nectomys palmipes (rodentia: cricetidae: sigmodontinae) from venezuela: description, molecular evidence, wolbachia pipientis screening.abstract: the onchocercid filaria litomosoides taylori sp. n. is described from the sigmodontine cricetid nectomys palmipes allen et chapman in northeast venezuela. a voucher specimen of the new species was used for molecular analysis of the coxi and 12s rdna genes, and screened for the presence of the endobacterium wolbachia pipientis. litomosoides taylori belongs to the "sigmodontis group" of litomosoides and a combination of characters can be used to distinguish it from the remaining 18 speci ...201121776894
wolbachia bacteria reside in host golgi-related vesicles whose position is regulated by polarity proteins.wolbachia pipientis are intracellular symbiotic bacteria extremely common in various organisms including drosophila melanogaster, and are known for their ability to induce changes in host reproduction. these bacteria are present in astral microtubule-associated vesicular structures in host cytoplasm, but little is known about the identity of these vesicles. we report here that wolbachia are restricted only to a group of golgi-related vesicles concentrated near the site of membrane biogenesis and ...201121829485
fatty acid components of larval ostrea edulis (l.): importance of triacylglycerols as a fatty acid reserve.1. the fatty acid profiles of all of the acyl-lipid classes of 1- and 10-day-old european oyster ostrea edulis (l.) larvae were studied in detail by capillary gas-liquid chromatography. 2. no significant changes in the fatty acids were detected between the different larval stages. 3. total lipid fatty acids showed a higher degree of unsaturation than previously reported. this may be a consequence of the extraction of lipids from the living tissues without sample storage. 4. one-third of the tria ...20113248373
Changes in the genetic structure of Aedes aegypti (Diptera: Culicidae) populations in Queensland, Australia, across two seasons: implications for potential mosquito releases.Diseases transmitted by mosquitoes could be controlled if vector populations were replaced with strains that have reduced vector competency. Such a strategy is being developed for control of dengue virus which is transmitted by Aedes aegypti (L.) (Diptera: Culicidae). Mosquitoes artificially infected with the bacterium, Wolbachia pipientis Hertig, are being assessed as candidates for release at the adult stage with the aim of replacement of the wild population. Wolbachia can reduce the capacity ...201121936318
a wolbachia symbiont in aedes aegypti disrupts mosquito egg development to a greater extent when mosquitoes feed on nonhuman versus human blood.a vertebrate bloodmeal is required by female mosquitoes of most species to obtain nutrients for egg maturation. the yellowfever mosquito, aedes aegypti (l.), feeds predominantly on humans, despite having the capacity to use blood from other hosts for this process. here, we report that female ae. aegypti infected with a virulent strain of the intracellular bacterium wolbachia pipientis (wmelpop) from drosophila melanogaster (meigen) have a reduced ability to use blood for egg development. blood f ...201121337952
a secure semi-field system for the study of aedes aegypti.new contained semi-field cages are being developed and used to test novel vector control strategies of dengue and malaria vectors. we herein describe a new quarantine insectary level-2 (qic-2) laboratory and field cages (james cook university mosquito research facility semi-field system; mrf sfs) that are being used to measure the impact of the endosymbiont wolbachia pipientis on populations of aedes aegypti in cairns australia.201121445333
wolbachia uses host micrornas to manipulate host gene expression and facilitate colonization of the dengue vector aedes aegypti.the obligate endosymbiont wolbachia pipientis is found in a wide range of invertebrates where they are best known for manipulating host reproduction. recent studies have shown that wolbachia also can modulate the lifespan of host insects and interfere with the development of human pathogens in mosquito vectors. despite considerable study, very little is known about the molecular interactions between wolbachia and its hosts that might mediate these effects. using microarrays, we show that the mic ...201121576469
[nursing and informatics. the prospects and implications]. 20113149012
cervical cancer in nuns and prostitutes: a plea for scientific continence. 20113290397
anomalies in composition of uremic lipoproteins isolated by gradient ultracentrifugation: relative enrichment of hdl in apolipoprotein c-iii at the expense of apolipoprotein a-i.using a discriminating gradient separation technique combined with careful analysis of lipid and apolipoprotein (apo) composition, serum lipoproteins of 20 chronically uremic patients have been compared with those of 19 normal controls matched for age and sex. in uremic subjects, serum vldl concentration was markedly increased. these particles were enriched in protein and cholesterol and relatively poor in triglycerides (tg). they contained more frequently apo b-48, and a decreased proportion of ...20113145749
neodymium: yag and argon laser iridotomy. long-term follow-up in a prospective, randomized clinical trial.neodymium:yag (nd:yag) and argon laser iridotomies were compared in a prospective, randomized clinical trial of 43 patients with bilateral chronic pupillary-block glaucoma. all patients had one eye randomly assigned to argon and the fellow eye assigned to nd:yag laser treatment. follow-up ranged from 20 to 42 months. iridotomy closure was not observed in nd:yag-treated eyes, but nine (21%) argon iridotomies required retreatment. visual loss due to progression of laser-induced lens or corneal dam ...20113062535
prostaglandin research. 20113078573
[resorption and metabolic utilization of d-[alpha-15n]lysine and l-[alpha-15n]lysine after oral administration, with special reference to the metabolism of intestinal bacteria].absorption of d-[alpha-15n]lysine and l-[alpha-15n]lysine following an oral single pulse labelling at a dosage of 5 mg 15n'/kg body weight was compared in four subjects aged 4 to 14 months. the wastages of 15n' in the faeces ranged from 0.3 to 5% of the input implying comparably high absorption rates of both the lysine enantiomers. only about 7.6% of the 15n from the alpha-amino groups were found in the urine after loading with l-[alpha-15n]lysine. in contrast, about 80.2% of the 15n' dose from ...20113128286
koro-like syndrome in maltese subject on the basis of chronic schizophrenia. 20113252941
koro-like syndrome in maltese subject on the basis of chronic schizophrenia. 20113252941
aids: opportunistic diseases and their physical assessment. 20113235987
translational control of insp3-induced chromatin condensation during the early cell cycles of sea urchin embryos.the cycles of dna synthesis and chromatin condensation in dividing cells are controlled by signals from the cytoplasm. changes in the concentration of free calcium (cai) in the cytoplasm control a variety of cellular functions and it has thus been suggested that observed variations in cai during the cell cycle may be the cytoplasmic signal that co-ordinates nuclear and cytoplasmic division. we show here that increases in cai induced by the calcium-releasing second messenger inositol 1,4,5-tripho ...20113127728
zonal distribution of prostatic adenocarcinoma. correlation with histologic pattern and direction of spread.for 104 prostate glands obtained at radical prostatectomy for adenocarcinoma, we mapped the tumor outline and determined the tumor volume, grade, and location relative to the transition zone boundary and location of the central zone. among the 88 cancers whose probable zone of origin could be identified, 68% arose in the peripheral zone, 24% arose in the transition zone, and 8% arose in the central zone. transition zone carcinomas had usually been diagnosed by transurethral resection (tur) and o ...20113202246
detection of wolbachia in the tick ixodes ricinus is due to the presence of the hymenoptera endoparasitoid ixodiphagus hookeri.the identification of micro-organisms carried by ticks is an important issue for human and animal health. in addition to their role as pathogen vectors, ticks are also the hosts for symbiotic bacteria whose impact on tick biology is poorly known. among these, the bacterium wolbachia pipientis has already been reported associated with ixodes ricinus and other tick species. however, the origins of wolbachia in ticks and their consequences on tick biology (known to be very diverse in invertebrates, ...201222292021
the small interfering rna pathway is not essential for wolbachia-mediated antiviral protection in drosophila melanogaster.wolbachia pipientis delays rna virus-induced mortality in drosophila spp. we investigated whether wolbachia-mediated protection was dependent on the small interfering rna (sirna) pathway, a key antiviral defense. compared to wolbachia-free flies, virus-induced mortality was delayed in wolbachia-infected flies with loss-of-function of sirna pathway components, indicating that wolbachia-mediated protection functions in the absence of the canonical sirna pathway.201222798369
no effect of wolbachia on resistance to intracellular infection by pathogenic bacteria in drosophila melanogaster.multiple studies have shown that infection with the endosymbiotic bacterium wolbachia pipientis confers drosophila melanogaster and other insects with resistance to infection by rna viruses. studies investigating whether wolbachia infection induces the immune system or confers protection against secondary bacterial infection have not shown any effect. these studies, however, have emphasized resistance against extracellular pathogens. since wolbachia lives inside the host cell, we hypothesized th ...201222808174
adequacy of chemically defined, water-soluble diet for germfree balb/c mice through successive generations and litters.to determine dietary adequacy, germfree balb/cann mice were fed ad libitum an ultrafiltered solution of chemically defined, water-soluble, low-molecular-weight nutrients. they received a measured daily supplement of membrane-filtered, distillation-purified soy oil containing vitamins a, d, e and k. mice were kept on ash-free filter paper bedding, which they freely consumed. on this regimen, germfree balb/c mice reproduced through nine generations, and through eight litters in one generation. ave ...20123772524
adequacy of chemically defined, water-soluble diet for germfree balb/c mice through successive generations and litters.to determine dietary adequacy, germfree balb/cann mice were fed ad libitum an ultrafiltered solution of chemically defined, water-soluble, low-molecular-weight nutrients. they received a measured daily supplement of membrane-filtered, distillation-purified soy oil containing vitamins a, d, e and k. mice were kept on ash-free filter paper bedding, which they freely consumed. on this regimen, germfree balb/c mice reproduced through nine generations, and through eight litters in one generation. ave ...20123772524
[chronic pancreatitis. surgical therapy by resection procedures].in 606 resections operative mortality fell from 10 to 1.2%. in distal resections in 66% good results were observed with a late mortality of 11%. a total mortality of 40% was found in total pancreatectomy, therefore this procedure was cancelled in 1980. in 289 partial duodeno-pancreatectomies combined with duct occlusion by ethibloc our operative mortality was 1%. late follow-up: free of pain 88%, recurrence in only 2.1%. preservation of endocrine function proven by a prospective study.20123431249
[obstetrics and gynecology of the innsbruck medical school]. 20123285598
delayed spontaneous alternation in purkinje cell degeneration mutant mice.purkinje cell degeneration (pcd) mutant mice lose cerebellar purkinje cells. it was found that pcd mice, contrary to normal mice, did not alternate spontaneously at any of 3 inter-trial intervals (15 s, 3 or 6 min). deficits in spontaneous alternation are typical of animals with brain damage in areas important in spatial learning. results are discussed in terms of a role for the cerebellum in spatially mediated behavior and behavioral inhibition.20123683990
laryngoscope blade breakage during intubation. 20123356060
psychophysiological effects of methylphenidate (ritalin). 20123313484
the expression of one ankyrin pk2 allele of the wo prophage is correlated with the wolbachia feminizing effect in isopods.the maternally inherited α-proteobacteria wolbachia pipientis is an obligate endosymbiont of nematodes and arthropods, in which they induce a variety of reproductive alterations, including cytoplasmic incompatibility (ci) and feminization. the genome of the feminizing wvulc wolbachia strain harboured by the isopod armadillidium vulgare has been sequenced and is now at the final assembly step. it contains an unusually high number of ankyrin motif-containing genes, two of which are homologous to t ...201222497736
the complexity of virus systems: the case of endosymbionts.host-microbe symbioses involving bacterial endosymbionts comprise some of the most intimate and long-lasting interactions on the planet. while restricted gene flow might be expected due to their intracellular lifestyle, many endosymbionts, especially those that switch hosts, are rampant with mobile dna and bacteriophages. one endosymbiont, wolbachia pipientis, infects a vast number of arthropod and nematode species and often has a significant portion of its genome dedicated to prophage sequences ...201222609369
intercommunity effects on microbiome and gpsghv density regulation in tsetse flies.tsetse flies have a highly regulated and defined microbial fauna made of 3 bacterial symbionts (obligate wigglesworthia glossinidia, commensal sodalis glossinidius and parasitic wolbachia pipientis) in addition to a dna virus (glossina pallidipes salivary gland hypertrophy virus, gpsghv). it has been possible to rear flies in the absence of either wigglesworthia or in totally aposymbiotic state by dietary supplementation of tsetse's bloodmeal. in the absence of wigglesworthia, tsetse females are ...201222874746
detection of wolbachia dna in blood for diagnosing filaria-associated syndromes in cats.a fundamental role for the endosymbiotic bacteria wolbachia pipientis in the pathogenesis of dirofilaria immitis infections has emerged in recent years. diagnostic opportunities arising from this breakthrough have not yet been fully exploited. this study was aimed at developing conventional and real-time pcr assays to carry out a molecular survey in a convenience sample of cats living in an area where d. immitis is endemic and to evaluate the detection of bacterial dna in blood as a surrogate as ...201222649020
comparative genomics suggests an independent origin of cytoplasmic incompatibility in cardinium hertigii.terrestrial arthropods are commonly infected with maternally inherited bacterial symbionts that cause cytoplasmic incompatibility (ci). in ci, the outcome of crosses between symbiont-infected males and uninfected females is reproductive failure, increasing the relative fitness of infected females and leading to spread of the symbiont in the host population. ci symbionts have profound impacts on host genetic structure and ecology and may lead to speciation and the rapid evolution of sex determina ...201223133394
drosophila melanogaster as a model organism for bluetongue virus replication and tropism.bluetongue virus (btv) is the etiological agent of bluetongue (bt), a hemorrhagic disease of ruminants that can cause high levels of morbidity and mortality. btv is an arbovirus transmitted between its ruminant hosts by culicoides biting midges (diptera: ceratopogonidae). recently, europe has experienced some of the largest bt outbreaks ever recorded, including areas with no known history of the disease, leading to unprecedented economic and animal welfare issues. the current lack of genomic res ...201222674991
tsetse-wolbachia symbiosis: comes of age and has great potential for pest and disease control.tsetse flies (diptera: glossinidae) are the sole vectors of african trypanosomes, the causative agent of sleeping sickness in human and nagana in animals. like most eukaryotic organisms, glossina species have established symbiotic associations with bacteria. three main symbiotic bacteria have been found in tsetse flies: wigglesworthia glossinidia, an obligate symbiotic bacterium, the secondary endosymbiont sodalis glossinidius and the reproductive symbiont wolbachia pipientis. in the present rev ...201222835476
wolbachia-induced aae-mir-12 mirna negatively regulates the expression of mct1 and mcm6 genes in wolbachia-infected mosquito cell line.best recognized for its role in manipulating host reproduction, the parasitic gram-negative wolbachia pipientis is known to colonize a wide range of invertebrates. the endosymbiotic bacterium has recently been shown to cause a life-shortening effect as well as inhibiting replication of arboviruses in aedes aegypti; although the molecular mechanisms behind these effects are largely unknown. micrornas (mirnas) have been determined to have a wide range of roles in regulating gene expression in euka ...201223166816
disruption of redox homeostasis leads to oxidative dna damage in spermatocytes of wolbachia-infected drosophila simulans.molecular interactions between symbiotic bacteria and their animal hosts are, as yet, poorly understood. the most widespread bacterial endosymbiont, wolbachia pipientis, occurs in high density in testes of infected drosophila simulans and causes cytoplasmic incompatibility (ci), a form of male-derived zygotic lethality. wolbachia grow and divide within host vacuoles that generate reactive oxygen species (ros), which in turn stimulate the up-regulation of antioxidant enzymes. these enzymes appear ...201222831171
infection with wolbachia protects mosquitoes against plasmodium-induced mortality in a natural system.in recent years, there has been a shift in the one host-one parasite paradigm with the realization that, in the field, most hosts are coinfected with multiple parasites. coinfections are particularly relevant when the host is a vector of diseases, because multiple infections can have drastic consequences for parasite transmission at both the ecological and evolutionary timescales. wolbachia pipientis is the most common parasitic microorganism in insects, and as such, it is of special interest fo ...201222533729
tandem repeat markers as novel diagnostic tools for high resolution fingerprinting of wolbachia.strains of the endosymbiotic bacterium wolbachia pipientis are extremely diverse both genotypically and in terms of their induced phenotypes in invertebrate hosts. despite extensive molecular characterisation of wolbachia diversity, little is known about the actual genomic diversity within or between closely related strains that group tightly on the basis of existing gene marker systems, including multiple locus sequence typing (mlst). there is an urgent need for higher resolution fingerprinting ...201222375862
age-related changes in postprandial plasma glucose, insulin, and free fatty acid concentrations in nondiabetic individuals.plasma glucose, insulin, and free fatty acid (ffa) concentrations were measured from 0800 to 1600 hours in 40 nondiabetic individuals, separated into younger (38 +/- 1.4 years) and older (64 +/- 1.5 years) age groups. meals were served at 0800 (20% total daily calories) and 1200 h (40% of total daily calories), and blood drawn just before the 0800 hours meal and at hourly intervals thereafter until 1600 hours. statistical evaluation of the results of these measurements indicated that day-long pl ...20123546468
[etiology and pathogenesis of synovitis villonodosa pigmentosa].articular pigmented villonodular synovitis is a benign synovial disease of unknown etiology. it is a proliferative disorder of the synovium that can involve the joints, tendon sheaths, and bursae. there is a predilection for involvement of the lower extremities, particularly the knees. there are two histologically similar lesions of pigmented villonodular synovitis: "nodular" and "diffuse" pigmented villonodular tenosynovitis. the typical clinical course consists of progressive and painful swell ...20123387098
the illusion of catch-up growth in premature infants. use of the growth index and age correction.growth data of 61 premature infants who were observed for 29 months were analyzed to determine if there is validity to the concept of catch-up growth. weight, length, and head circumference were recorded at each visit. for each measurement, a growth index was calculated to facilitate comparison of infants of different ages and sexes. the age of a child at each visit was also corrected for prematurity by subtracting the number of weeks premature from the postnatal chronological age to generate a ...20123578164
[various aspects of the pathogenesis, clinical picture and treatment of migraine].in a series of 108 patients with migraine the authors studied the characteristics of the emotional-personality sphere and autonomic nervous system, as well as the status of the brain nonspecific systems. the findings of nocturnal electropolygraphy were also used in the study. the efficacy of drugs with antiserotonin action versus multiple modality therapy was compared. the observed disorders in the psychic, autonomic and endocrine systems are interpreted as a consequence of dysfunction of the ce ...20123630504
[various aspects of the pathogenesis, clinical picture and treatment of migraine].in a series of 108 patients with migraine the authors studied the characteristics of the emotional-personality sphere and autonomic nervous system, as well as the status of the brain nonspecific systems. the findings of nocturnal electropolygraphy were also used in the study. the efficacy of drugs with antiserotonin action versus multiple modality therapy was compared. the observed disorders in the psychic, autonomic and endocrine systems are interpreted as a consequence of dysfunction of the ce ...20123630504
anesthesia-related maternal mortality in michigan, 1972 to 1984.we reviewed maternal deaths in the state of michigan occurring from 1972 through 1984. there were 15 maternal deaths in which anesthesia was considered the primary cause and 4 deaths in which anesthesia was a contributory factor. complications of regional anesthesia were the main cause of death during the early part of the period, whereas the inability to accomplish endotracheal intubation emerged as the principal cause of death in recent years. eleven of the 15 patients had undergone cesarean s ...20123394738
focal dermal hypoplasia syndrome (goltz syndrome): the first dental case report. 20123466146
tooth loss, mastication, and nutrition: an overview. 20123510240
craniomandibular aspects of geriatric dentistry. 20123458923
[changes in s-adenosylmethionine metabolism in liver cirrhosis]. 20123287509
evaluation of developmental toxicity data: a discussion of some pertinent factors and a proposal.there is currently no well-accepted standard method for evaluation of developmental toxicity data. this paper presents one approach to the evaluation of developmental toxicity data. we initially identify some pertinent factors that influence the interpretation of animal data and summarize the literature pertaining to these factors. such factors include the quality and quantity of data and the relationship between maternal and developmental toxicity. we proceed with a discussion of quantitative a ...20123287508
incidence of fetal alcohol syndrome and economic impact of fas-related anomalies.the world-wide incidence of the fetal alcohol syndrome (fas) is 1.9 per 1000 live births. incidence rates vary considerably, however, depending on study site. mental retardation is a cardinal feature of fas and is now recognized as the leading known cause of mental retardation in the western world. conservatively estimated for the united states, the economic cost associated with fas-related growth retardation, surgical repair of organic anomalies (e.g. cleft palate, tetralogy of fallot), treatme ...20123545731
abnormal distribution of t cell subsets in athymic mice. 20123486898
three dimensional analysis of the face in respect of zygomatic fractures and evaluation of the surgery with the aid of moiré topography.in this study, the author analyzed the facial deformity of patients with zygomatic fractures, using moiré topography, which is a method of three dimensional morphometry. facial moiré photographs of patients were taken at 45 degree angles before and after operation and were quantitatively analyzed for degree of deformity by computer data processing. each data was compared in the interval between injury and operation and in respect of the surgical procedures. radiographic findings and normal indiv ...20123473082
choice of techniques in nasal repairs.the authors after classifying skin loss of the nose according to their size and site, resume the techniques they normally use in every kind of loss. they suggest those most reliable and easy to perform.20123557208
aids update. 20123416142
rehabilitation of chronic schizophrenics in a developing country.mental health services in pakistan, as in most developing countries, have not advanced beyond elementary level. considering the population size, there are few beds in psychiatric wards or hospitals for those in need, and little, if any, opportunity for mentally ill individuals to receive aid and assistance in the community. one model which provides a comprehensive array of services for chronic mental patients in the community is known as the 'clubhouse'. since 1971, fountain house has provided s ...20123429396
vagina: evaluation with mr imaging. part ii. neoplasms.the potential of magnetic resonance (mr) imaging in the detection of vaginal tumors and the assessment of their extent was evaluated retrospectively in 87 patients in whom primary, metastatic, or recurrent vaginal cancer was clinically suspected. mr findings were compared with the results of surgery and/or biopsy. results of histopathologic study verified a normal vagina in 51 patients, benign cysts in two, primary tumor in four, metastatic cancer in 22, and recurrent tumor in eight. mr imaging ...20123420257
estimation of surface-bound heparin activity: a comparison of methods.we compared two assays for estimating the amount of active heparin bound to a catheter surface: 1) a kinetic assay based on the inactivation of thrombin by antithrombin iii, and 2) thrombin uptake. both assays were used to estimate the amount of heparin activity on a series of catheters coated with no heparin, covalently bound heparin, and ionically bound heparin. the kinetic assay produced estimates of surface-bound heparin activity and showed that some binding methods resulted in destruction o ...20123410869
postanesthesia recovery scores and postoperative hypoxemia. 20123421487
the bound water fraction and the hela cell cycle. 20123406139
pulmonary function testing in the screening of workers: guidelines for instrumentation, performance, and interpretation.medical surveillance of workers exposed to potential respiratory hazards may be a valuable tool in early recognition and prevention of certain occupational lung diseases. the use of pulmonary function tests, particularly spirometry, has been widely accepted as an integral part of respiratory surveillance. a national aeronautics and space administration contract report on the occupational safety and health administration medical and workplace surveillance requirements and recommendations by the n ...20123772542
pulmonary function testing in the screening of workers: guidelines for instrumentation, performance, and interpretation.medical surveillance of workers exposed to potential respiratory hazards may be a valuable tool in early recognition and prevention of certain occupational lung diseases. the use of pulmonary function tests, particularly spirometry, has been widely accepted as an integral part of respiratory surveillance. a national aeronautics and space administration contract report on the occupational safety and health administration medical and workplace surveillance requirements and recommendations by the n ...20123772542
[insurance (third party) dental health care over the years 1981-1985. trends in the private dental health care sector]. 20123484133
[gas-liquid chromatography in sanitary-chemical studies of polymers for use in the food industry]. 20124553623
wolbachia from the planthopper laodelphax striatellus establishes a robust, persistent, streptomycin-resistant infection in clonal mosquito cells.the obligate intracellular bacterium, wolbachia pipientis (rickettsiales: anaplasmataceae), distorts reproduction of its arthropod hosts to facilitate invasion of naïve populations. this property makes wolbachia an attractive "gene drive" agent with potential applications in the control of insect vector populations. genetic manipulation of wolbachia will require in vitro systems for its propagation, genetic modification, amplification, and introduction into target insects. here we show that wolb ...201223271364
[kidney concentrating ability in children and adolescents with normal kidneys]. 20123398393
evaluation of low-intensity transcutaneous electrical nerve stimulation in combination with aspirin for reduction of controlled thermal sensation.reductions in cutaneous thermal sensation produced by placebo, aspirin, transcutaneous electrical nerve stimulation, and transcutaneous electrical nerve stimulation plus aspirin were compared in 60 normal volunteers. the combination of transcutaneous electrical nerve stimulation plus aspirin produced a statistically significant reduction as compared with placebo. the results suggest this treatment combination may provide levels of analgesia useful for completion of minor dental procedures.20123266912
radiographic anatomy of the calcaneus. part iii: superior surface. 20123430354
passive smoking and colic-like behaviour in babies. 20123372251
[pathophysiologic observations of facial neuralgia].the different etiology and pathogenesis of face-neuralgiae requires a spezific therapy of the respective illness. new aspects are formed in the last years in the so-called idiopathic neuralgia. she has good chances with the therapy through the jannetta-operation. the evident mechanical lesion by compression, the ephaptic genesis and the special pain-characterization with trigger-attacks not support the "idiopathic". this is called "ictal neuralgia". the paper attempts pathophysiological to expla ...20123244807
Wolbachia pipientis is associated with different mitochondrial haplotypes in natural populations of Drosophila willistoni.The prevalence of the endosymbiont Wolbachia pipientis and its effects on mitochondrial genetic diversity were analyzed in natural populations of Drosophila willistoni, a neotropical species recently infected. Total infection rate was 55% and no evidence was found that the Wolbachia infection decreased the diversity of mtDNA. Wolbachia was seen to be associated with different mitochondria, suggesting multiple horizontal transmission events and/or transmission paternal leakage of mitochondrial an ...201221945051
plasma progesterone concentrations in female little brown bats (myotis lucifugus) during hibernation.monthly collections of hibernating little brown bats contained (1) nulliparous females with small uteri and no antral follicles, (2) nulliparous females with swollen uteri and mature follicles, and (3) parous females, which, despite obvious differences in reproductive status, had equivalent plasma progesterone values. during the principal study season, mean monthly progesterone concentrations (measured by radioimmunoassay) showed recurrent increases with an apparent periodicity of about 60 days, ...20123397958
synthesis of a trans-syn thymine dimer building block. solid phase synthesis of cgtat[t,s]tatgc.the synthesis of a building block for the sequence specific introduction of the trans-syn thymine dimer into oligonucleotides via solid phase dna synthesis technology is described. cgtat[t,s]tatgc was synthesized in 48% overall yield by a partially automated procedure. the stepwise coupling yield for addition of the trans-syn thymine dimer building block was 58%. the dimer containing oligonucleotide was characterized by 500 mhz 1h cosy and noesy spectroscopy and 202.5 mhz 31p nmr. the 1h chemica ...20123387219
a multicentre study of flumequine in the treatment of urinary tract infections.the efficacy and safety of flumequine were evaluated in the treatment of 121 cases uncomplicated (65.5%) and complicated (34.5%) urinary tract infections (uti) when given as a dose of 400 mg bd. duration of treatment ranged from 7-15 days, with a mean of 10. thirty days post-therapy, cure persisted in 92.3% of the patients with uncomplicated uti and in 53.7% of those with complicated uti. relapse or re-infection occurred in 34.1% of the patients with complicated uti, and in 12.2%, the infecting ...20123356617
health risks among submarine personnel in the u.s. navy, 1974-1979.this study evaluated health risks associated with u.s. navy submarine duty by comparing hospitalization rates of submariners with surface ship personnel. the groups were compared using age-adjusted hospitalization rates for 16 major diagnostic categories and several specific diagnoses postulated to be submarine associated. submarine personnel did not have significantly higher hospitalization rates for any diagnostic categories nor for any of the submarine-associated illnesses. submariner relativ ...20133686743
hypermagnesemia and progression of renal failure associated with renacidin therapy.renacidin is a urinary stone dissolving agent composed primarily of gluconic and citric acids and their magnesium salts, buffered to a ph of 4. we describe its use in a child with oxalosis, disabling renal colic and deteriorating renal function in whom its use was associated with hypermagnesemia and rapid progression of the renal failure. possible mechanisms for the deterioration in renal function are discussed.20133720036
[pregnancy and functional disorders of the thyroid gland]. 20133719755
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