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high metabolic activity in the visual cortex of early blind human subjects.glucose metabolism has been studied in the visual cortex of early blind human subjects. in the forebrain of these subjects, regional glucose utilization was the highest in the striate and prestriate cortical areas. furthermore, this activity was higher than in blindfolded sighted subjects, whether at rest or during an auditory or tactile task. these observations raise the question of the functionality of the blind's visual cortex.19883370494
passive smoking and colic-like behaviour in babies. 20123372251
myths that threaten. 20103380485
[etiology and pathogenesis of synovitis villonodosa pigmentosa].articular pigmented villonodular synovitis is a benign synovial disease of unknown etiology. it is a proliferative disorder of the synovium that can involve the joints, tendon sheaths, and bursae. there is a predilection for involvement of the lower extremities, particularly the knees. there are two histologically similar lesions of pigmented villonodular synovitis: "nodular" and "diffuse" pigmented villonodular tenosynovitis. the typical clinical course consists of progressive and painful swell ...20123387098
synthesis of a trans-syn thymine dimer building block. solid phase synthesis of cgtat[t,s]tatgc.the synthesis of a building block for the sequence specific introduction of the trans-syn thymine dimer into oligonucleotides via solid phase dna synthesis technology is described. cgtat[t,s]tatgc was synthesized in 48% overall yield by a partially automated procedure. the stepwise coupling yield for addition of the trans-syn thymine dimer building block was 58%. the dimer containing oligonucleotide was characterized by 500 mhz 1h cosy and noesy spectroscopy and 202.5 mhz 31p nmr. the 1h chemica ...20123387219
anesthesia-related maternal mortality in michigan, 1972 to 1984.we reviewed maternal deaths in the state of michigan occurring from 1972 through 1984. there were 15 maternal deaths in which anesthesia was considered the primary cause and 4 deaths in which anesthesia was a contributory factor. complications of regional anesthesia were the main cause of death during the early part of the period, whereas the inability to accomplish endotracheal intubation emerged as the principal cause of death in recent years. eleven of the 15 patients had undergone cesarean s ...20123394738
[establishment of the maximum permissible concentration of polydimethyldiallylammonium chloride in reservoir water]. 19883396898
plasma progesterone concentrations in female little brown bats (myotis lucifugus) during hibernation.monthly collections of hibernating little brown bats contained (1) nulliparous females with small uteri and no antral follicles, (2) nulliparous females with swollen uteri and mature follicles, and (3) parous females, which, despite obvious differences in reproductive status, had equivalent plasma progesterone values. during the principal study season, mean monthly progesterone concentrations (measured by radioimmunoassay) showed recurrent increases with an apparent periodicity of about 60 days, ...20123397958
[kidney concentrating ability in children and adolescents with normal kidneys]. 20123398393
7b2, a new protein secreted by human functionless pituitary tumours, in vitro.a novel pituitary protein, 7b2, of approximately 180 amino acids has been suggested to colocalise with lh in the pituitary gonadotropes. increased secretion of lh is known to occur in functionless pituitary tumours. we have therefore measured 7b2 immunoreactive equivalents in the 24-h medium of explant pituitary cultures prepared from 17 functionless, 20 somatotropic, 16 prl secreting and 8 corticotropic adenomas. a synthetic fragment corresponding to amino acids 23-39 of 7b2 was used to raise a ...19883400405
4-amino-3-(2,3,5-tri-o-benzyl-beta-d-ribofuranosyl)-5-pyrazole-carb oni trile. synthesis and conversion into a sugar-blocked 5,7-disubstituted formycin analog.the title compound, a potential intermediate to protected c-nucleoside analogs related to formycin a, was synthesized via a new route wherein 2,3,5-tri-o-benzyl-1-o-p-nitrophenyl)-d-ribofuranose was converted to 2,5-anhydro-3,4,6-tri-o-benzyl-d-allonic acid, and further transformed into 4-(tert-butyloxycarbonyl)-5-ethoxycarbonyl-3-(2,3,5-tri-o-benzyl-beta-d- ribofuranosyl)pyrazole. after amidation and dehydration to form the 4-(tert-butyloxycarbonyl)-5-pyrazolecarbonitrile, acidolysis followed b ...20103401884
the bound water fraction and the hela cell cycle. 20123406139
convergent afferent inputs to neurones in nucleus paragigantocellularis lateralis in the cat.neuronal activity was recorded in nucleus paragigantocellularis lateralis (pgl) of the cat in response to stimulation of the dorsal periaqueductal grey matter (dpag), parabrachial nucleus (pbn) nucleus raphe magnus (nrm), and nucleus tractus solitarii (nts). stimulation in dpag or pbn evoked excitatory responses whilst the prevalent response to stimulation in nrm or nts was inhibition of neuronal activity. 45/55 (82%) of cells tested received convergent inputs from 2 or more sites of stimulation ...19883409033
estimation of surface-bound heparin activity: a comparison of methods.we compared two assays for estimating the amount of active heparin bound to a catheter surface: 1) a kinetic assay based on the inactivation of thrombin by antithrombin iii, and 2) thrombin uptake. both assays were used to estimate the amount of heparin activity on a series of catheters coated with no heparin, covalently bound heparin, and ionically bound heparin. the kinetic assay produced estimates of surface-bound heparin activity and showed that some binding methods resulted in destruction o ...20123410869
aids update. 20123416142
vagina: evaluation with mr imaging. part ii. neoplasms.the potential of magnetic resonance (mr) imaging in the detection of vaginal tumors and the assessment of their extent was evaluated retrospectively in 87 patients in whom primary, metastatic, or recurrent vaginal cancer was clinically suspected. mr findings were compared with the results of surgery and/or biopsy. results of histopathologic study verified a normal vagina in 51 patients, benign cysts in two, primary tumor in four, metastatic cancer in 22, and recurrent tumor in eight. mr imaging ...20123420257
postanesthesia recovery scores and postoperative hypoxemia. 20123421487
[screening and other alternatives in the fight against hiv]. 19873424318
mammalian alcohol dehydrogenase: characteristics of class iii isoenzymes.the kinetic characteristics of alcohol dehydrogenase class iii have been studied using class iii isoenzymes purified from human liver (x-adh) and rat liver (adh-2). our results confirm that long chain primary alcohols and aldehydes are the best substrates, although some aromatic compounds can also be actively metabolized. kinetic analysis suggests an ordered bibi mechanism for x-adh. ethanol can be oxidized by class iii isoenzymes at high substrate concentration, but with a very slow rate. thus, ...19873426675
rehabilitation of chronic schizophrenics in a developing country.mental health services in pakistan, as in most developing countries, have not advanced beyond elementary level. considering the population size, there are few beds in psychiatric wards or hospitals for those in need, and little, if any, opportunity for mentally ill individuals to receive aid and assistance in the community. one model which provides a comprehensive array of services for chronic mental patients in the community is known as the 'clubhouse'. since 1971, fountain house has provided s ...20123429396
radiographic anatomy of the calcaneus. part iii: superior surface. 20123430354
[chronic pancreatitis. surgical therapy by resection procedures].in 606 resections operative mortality fell from 10 to 1.2%. in distal resections in 66% good results were observed with a late mortality of 11%. a total mortality of 40% was found in total pancreatectomy, therefore this procedure was cancelled in 1980. in 289 partial duodeno-pancreatectomies combined with duct occlusion by ethibloc our operative mortality was 1%. late follow-up: free of pain 88%, recurrence in only 2.1%. preservation of endocrine function proven by a prospective study.20123431249
[analysis of the chemosensitivity test by human tumor clonogenic assay and subrenal capsule assay].the antitumor activities of several chemotherapeutic agents were tested in the human tumor clonogenic assay (htca) and in subrenal capsule assay (srca). the results obtained in these two assays and clinical response were compared. 1. colony growth was observed in 43 of 73 tumors (58.9%), and the adequate colony growth to evaluate the response of therapeutic groups was obtained in 21 tumors (28.8%). 2. control growth adequate to meet evaluable assay criteria was obtained in 38 of 43 tumors (88.4% ...19873431536
[lysosomal cationic proteins of granulocytes in the blood of healthy and sick monkeys]. 19873433992
craniomandibular aspects of geriatric dentistry. 20123458923
focal dermal hypoplasia syndrome (goltz syndrome): the first dental case report. 20123466146
three dimensional analysis of the face in respect of zygomatic fractures and evaluation of the surgery with the aid of moiré topography.in this study, the author analyzed the facial deformity of patients with zygomatic fractures, using moiré topography, which is a method of three dimensional morphometry. facial moiré photographs of patients were taken at 45 degree angles before and after operation and were quantitatively analyzed for degree of deformity by computer data processing. each data was compared in the interval between injury and operation and in respect of the surgical procedures. radiographic findings and normal indiv ...20123473082
[insurance (third party) dental health care over the years 1981-1985. trends in the private dental health care sector]. 20123484133
abnormal distribution of t cell subsets in athymic mice. 20123486898
relationships between pulmonary inflammation, plasma transudation, and oxygen metabolite secretion by alveolar macrophages.we have previously shown that alveolar macrophages from normal rabbit lungs do not synthesize reactive oxygen intermediates unless first conditioned by culture in vitro in the presence of serum for 24 to 48 hr. this conditioning process is mediated by a serum constituent that partitions on gel exclusion columns with an apparent m.w. of 30,000 to 50,000 daltons. alveolar macrophage conditioning in vitro requires protein synthesis, is associated with the generation of membrane nadph oxidase activi ...19863486910
a common mechanism of chromosomal translocation in t- and b-cell neoplasia.the chromosomal breakpoint involved in the t(8;14)(q24;q11) chromosome translocation in the skw-3 cell line, which directly involves the 3' flanking region of the c-myc gene, was cloned and sequenced. the breakpoint on chromosome 8 mapped to a position 3 kb 3' of c-myc while the chromosome 14 breakpoint occurred 36 kb 5' of the gene for the constant region of the alpha chain of the t-cell receptor (tcr). the translocation resulted in a precise rearrangement of sequences on chromosome 8 and what ...19863490692
[cigarette smoking and lung metabolism--effects of cigarette smoking on plasma levels of complement c3a and c5a in rabbits]. 19873500346
tooth loss, mastication, and nutrition: an overview. 20123510240
physiology and pathophysiology of the colonic circulation.there is growing evidence that colonic blood flow is controlled by both intrinsic and extrinsic factors. the existence of intrinsic vascular control mechanisms is evidenced by pressure-flow (and oxygen uptake) autoregulation, reactive hyperemia, vascular responses to acute venous hypertension, and a functional hyperemia. although myogenic factors have long been considered to be solely responsible for the intrinsic ability of the colon to regulate its blood flow, recent developments indicate that ...19863536216
insulin stimulates cord blood erythroid progenitor growth: evidence for an aetiological role in neonatal polycythaemia.polycythaemia in the neonate is a serious pathologic entity which occurs particularly in infants of diabetic mothers (idm) and small-for-gestational age (sga) infants. both of these conditions are associated with fetal hyperinsulinaemia. cultures of cord blood mononuclear cells from polycythaemic idm showed increased growth of late erythroid progenitor colonies, compared to cord blood mononuclear cells from non-polycythaemic infants, reflecting a possible expansion of this progenitor population ...19863539174
interferon in renal cell carcinoma. the ucla experience.three sequential studies of alpha interferon were performed in a total of 84 evaluable patients with metastatic renal cell carcinoma. in study i, conducted from 1981 to 1982, 43 patients received human leukocyte alpha interferon (ifn alpha) 3 x 10(6) u/day, 5 days per week for 12 weeks. in study ii, performed in 1983, vinblastine (0.1 mg/kg/week) was added to the same ifn alpha regimen in 22 subjects. study iii, held from 1984 to 1985, evaluated the effects of escalating doses of interferon alfa ...19873542184
incidence of fetal alcohol syndrome and economic impact of fas-related anomalies.the world-wide incidence of the fetal alcohol syndrome (fas) is 1.9 per 1000 live births. incidence rates vary considerably, however, depending on study site. mental retardation is a cardinal feature of fas and is now recognized as the leading known cause of mental retardation in the western world. conservatively estimated for the united states, the economic cost associated with fas-related growth retardation, surgical repair of organic anomalies (e.g. cleft palate, tetralogy of fallot), treatme ...20123545731
age-related changes in postprandial plasma glucose, insulin, and free fatty acid concentrations in nondiabetic individuals.plasma glucose, insulin, and free fatty acid (ffa) concentrations were measured from 0800 to 1600 hours in 40 nondiabetic individuals, separated into younger (38 +/- 1.4 years) and older (64 +/- 1.5 years) age groups. meals were served at 0800 (20% total daily calories) and 1200 h (40% of total daily calories), and blood drawn just before the 0800 hours meal and at hourly intervals thereafter until 1600 hours. statistical evaluation of the results of these measurements indicated that day-long pl ...20123546468
the silk wrap technique for composite bonding. 20133554047
choice of techniques in nasal repairs.the authors after classifying skin loss of the nose according to their size and site, resume the techniques they normally use in every kind of loss. they suggest those most reliable and easy to perform.20123557208
tobacco's radiation: its sources and potential hazards. 20133574847
fine structure of the organic matrix of human pancreatic stones.pancreatic stones that were removed from the pancreatic ducts of patients with chronic calcifying pancreatitis were decalcified so the organic matrix could be studied by scanning and transmission electron microscopy. the observations made by scanning electron microscopy were compared with those made on undecalcified stones, and the findings were correlated with light microscopic observations. after the calcium carbonate was removed, the stones consisted of multiple partitions arranged like a spo ...19863575306
the illusion of catch-up growth in premature infants. use of the growth index and age correction.growth data of 61 premature infants who were observed for 29 months were analyzed to determine if there is validity to the concept of catch-up growth. weight, length, and head circumference were recorded at each visit. for each measurement, a growth index was calculated to facilitate comparison of infants of different ages and sexes. the age of a child at each visit was also corrected for prematurity by subtracting the number of weeks premature from the postnatal chronological age to generate a ...20123578164
ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect.acute ethanol intake has been shown to decrease plasma testosterone levels in rodents and man. this is mainly due to inhibition of testosterone synthesis, but there is still some controversy about the mechanisms responsible for the inhibition. these mechanisms were studied in the present experiments with isolated rat leydig cells. leydig cells were incubated for two hours in sealed plastic vials with various concentrations of ethanol (0.3-40 mm) or acetaldehyde (5-40 microm). very low ethanol co ...19873593480
alcohol and the brain: neuropsychological correlates. 20133597943
monte carlo study of electron spectra produced in semi-infinite and finite water phantoms irradiated by photons of energies up to 2 mev.a monte carlo calculation for the initial electron energy spectra produced in semi-infinite and finite water phantoms irradiated by photons of energies up to 2 mev and photons from 60co are presented incorporating successive compton scattering, photoelectric absorption and auger effect. the backscattering of photons through the top of the phantom and transmission of photons out of the finite phantom through the sides also are considered. the results are compared with the earlier calculation for ...20133610642
bronchial obstruction caused by a solitary endobronchial non-hodgkin lymphoma. 20133622663
[various aspects of the pathogenesis, clinical picture and treatment of migraine].in a series of 108 patients with migraine the authors studied the characteristics of the emotional-personality sphere and autonomic nervous system, as well as the status of the brain nonspecific systems. the findings of nocturnal electropolygraphy were also used in the study. the efficacy of drugs with antiserotonin action versus multiple modality therapy was compared. the observed disorders in the psychic, autonomic and endocrine systems are interpreted as a consequence of dysfunction of the ce ...20123630504
[various aspects of the pathogenesis, clinical picture and treatment of migraine].in a series of 108 patients with migraine the authors studied the characteristics of the emotional-personality sphere and autonomic nervous system, as well as the status of the brain nonspecific systems. the findings of nocturnal electropolygraphy were also used in the study. the efficacy of drugs with antiserotonin action versus multiple modality therapy was compared. the observed disorders in the psychic, autonomic and endocrine systems are interpreted as a consequence of dysfunction of the ce ...20123630504
cardiovascular response to sudden strenuous exercise.cardiac responses to sudden strenuous exercise were studied in seven dogs instrumented to measure cardiac output (q), stroke volume (sv), left ventricular (lv) pressure, aortic pressure and circumflex coronary blood flow (cbf). the dogs were run on a treadmill at 12.9 km/h, 20% grade for 15s without prior warm-up. during the first 10s of the run, hr and q increased rapidly. by 2s, myocardial o2 requirements, as estimated from either the tension time index (tti) or calculated wall tension, had in ...19873632566
promoting informed consent of women in labor.laboring women are increasingly being asked to participate in perinatal research. these women should be considered captive or special subjects who deserve greater protection of their rights. essential elements of informed consent are reviewed. specific guidelines are suggested for promoting informed consent for women in labor participating in clinical research.19863639933
perceptual and behavioural effects of immobility and social isolation in hospitalized orthopedic patients. 20133644253
[rectal bladder. evaluation of its tolerance]. 20133674992
the measurement of heart size in the antero-posterior chest radiograph.a computed tomography model was used in eight patients to show how the heart diameter and cardiothoracic ratio might change between antero-posterior and postero-anterior positions. results were compared with measurements made on erect antero-posterior chest radiographs taken on 103 patients without cardiac failure (controls) and 106 with cardiac failure. an upper limit of cardiothoracic ratio of 55% and of heart diameter of 165 mm in males and 150 mm in females was shown to provide useful discri ...20133676657
delayed spontaneous alternation in purkinje cell degeneration mutant mice.purkinje cell degeneration (pcd) mutant mice lose cerebellar purkinje cells. it was found that pcd mice, contrary to normal mice, did not alternate spontaneously at any of 3 inter-trial intervals (15 s, 3 or 6 min). deficits in spontaneous alternation are typical of animals with brain damage in areas important in spatial learning. results are discussed in terms of a role for the cerebellum in spatially mediated behavior and behavioral inhibition.20123683990
sensitivity and criterion effects in the spatial cuing of visual attention. 20133684496
effect of prostaglandin e1 on deposition of autologous labelled platelets onto human atherosclerotic lesions in vivo.the effects of infusions of prostaglandin e1 (pge1) on platelet deposition at atherosclerotic sites in vivo in man have been examined. thirteen patients with atherosclerotic vascular disease received intravenous pge1 25 mg/kg/min for 6 hours daily for 5 days. prostaglandin e1 had no effect on platelet uptake at atherosclerotic sites but prolonged platelet half-life significantly (p less than 0.001).19873684830
health risks among submarine personnel in the u.s. navy, 1974-1979.this study evaluated health risks associated with u.s. navy submarine duty by comparing hospitalization rates of submariners with surface ship personnel. the groups were compared using age-adjusted hospitalization rates for 16 major diagnostic categories and several specific diagnoses postulated to be submarine associated. submarine personnel did not have significantly higher hospitalization rates for any diagnostic categories nor for any of the submarine-associated illnesses. submariner relativ ...20133686743
[successful chemotherapy with adriamycin and methotrexate in a case of advanced transitional cell carcinoma of the ureter--a clinical application of subrenal capsule assay].a case of advanced transitional cell carcinoma of the left ureter was treated with a combination of adriamycin and methotrexate. these drugs were selected using the subrenal capsule assay for which tumor tissues were obtained from a biopsy specimen of the left supraclavicular lymph node. complete regression of left supraclavicular lymph node metastasis and 90% regression of para-aortic lymph node metastasis were obtained after four courses of the combination therapy. subsequently, left total nep ...20133688896
a new autosomal dominant craniofacial deafness syndrome.a jewish family is reported in which the proband and her father had congenital hearing loss and unusual facies consisting of facial asymmetry, temporal alopecia with frontal bossing, a broad nasal root and small nasal alae. in addition, both were born with a short frenulum of the tongue. we believe these findings represent a new autosomal dominant deafness syndrome with distinct craniofacial features.20133690878
[relationship between microflora of the upper small intestine and steatorrhoea in patients with extensive gastric resection]. 20133694857
[experimental hypovitaminosis d in guinea pigs administered different amounts of vitamin c].the experimental model of d-hypovitaminosis is first obtained on guinea pigs. it is established that the least degree of its manifestation is determined under conditions of the optimal supply of the organism with vitamin c. the necessity of using ascorbic acid in a complex of rachitis prophylaxis measures is substantiated.19863705209
infant mortality decline in malaysia, 1946-1975: the roles of changes in variables and changes in the structure of relationships.this analysis has identified several factors contributing to the dramatic decline in infant mortality since world war ii in malaysia, as well as one factor that prevented the infant mortality rate from declining even more rapidly. our main findings are the following: on average, mothers' education more than doubled over the study period, contributing to the decline in their infants' mortality. in addition, the beneficial effect of mothers' education on infant survival appears to have become stro ...20133709892
[modification of tear film break-up time by hormonal contraceptives]. 20133710337
[pregnancy and functional disorders of the thyroid gland]. 20133719755
hypermagnesemia and progression of renal failure associated with renacidin therapy.renacidin is a urinary stone dissolving agent composed primarily of gluconic and citric acids and their magnesium salts, buffered to a ph of 4. we describe its use in a child with oxalosis, disabling renal colic and deteriorating renal function in whom its use was associated with hypermagnesemia and rapid progression of the renal failure. possible mechanisms for the deterioration in renal function are discussed.20133720036
a laboratory investigation of two new portable gas analysers.two new portable infrared gas analysers, the irina (drägerwerke, lübeck, germany) and the normac (datex instrumentarium corporation, helsinki, finland), were tested and the results compared to those from such established methods as gaschromatography and the beckman lb-2 (beckman, usa) infrared gas analyser using exactly defined gas mixtures from a vaporizer developed in our laboratory. the analysers were evaluated for their accuracy and precision, noise, zero stability, gain stability and the im ...20133722981
teaching in medicine.this brief review has highlighted the important role of the clinician as a medical teacher. indeed, it is difficult to be one without the other. the aims and challenges to medical education have been described, together with the various settings in which teaching can occur. the medical teacher has a range of functions, including the development of educational programmes for special groups, a knowledge of a wide range of techniques for medical education and the ability to identify informal teachi ...20133738474
diagnosis of wide qrs tachyarrhythmias: poor atrial echogram specificity in cases of atrioventricular association. 20133751944
effect of sodium pentobarbital on behavioral thermoregulation in rats and mice.in this study on behavioral thermoregulation, male sprague-dawley rats were given intraperitoneal (ip) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male cba/j mice were given doses of 0, 5, 10, 15 or 30 mg/kg. the animals were immediately placed in a temperature gradient which allowed them to select their preferred ambient temperature (ta). the preferred ta of rats increased following an injection of 10 mg/kg sodium pentobarbital, whereas, the barbiturate had no eff ...19863754969
simple diagnosis of the zellweger syndrome by gas-liquid chromatography of dimethylacetals.the absence of peroxisomes in patients with the cerebrohepatorenal syndrome of zellweger leads to several biochemical abnormalities, including deficient synthesis of plasmalogens as well as accumulation of very long-chain fatty acids and intermediates in bile acid biosynthesis. accumulation of very long-chain fatty acids in serum and fibroblasts has hitherto been used most extensively for diagnosis. due to the relatively small amounts of the very long-chain fatty acids also in the zellweger pati ...20083760714
adequacy of chemically defined, water-soluble diet for germfree balb/c mice through successive generations and litters.to determine dietary adequacy, germfree balb/cann mice were fed ad libitum an ultrafiltered solution of chemically defined, water-soluble, low-molecular-weight nutrients. they received a measured daily supplement of membrane-filtered, distillation-purified soy oil containing vitamins a, d, e and k. mice were kept on ash-free filter paper bedding, which they freely consumed. on this regimen, germfree balb/c mice reproduced through nine generations, and through eight litters in one generation. ave ...20123772524
adequacy of chemically defined, water-soluble diet for germfree balb/c mice through successive generations and litters.to determine dietary adequacy, germfree balb/cann mice were fed ad libitum an ultrafiltered solution of chemically defined, water-soluble, low-molecular-weight nutrients. they received a measured daily supplement of membrane-filtered, distillation-purified soy oil containing vitamins a, d, e and k. mice were kept on ash-free filter paper bedding, which they freely consumed. on this regimen, germfree balb/c mice reproduced through nine generations, and through eight litters in one generation. ave ...20123772524
pulmonary function testing in the screening of workers: guidelines for instrumentation, performance, and interpretation.medical surveillance of workers exposed to potential respiratory hazards may be a valuable tool in early recognition and prevention of certain occupational lung diseases. the use of pulmonary function tests, particularly spirometry, has been widely accepted as an integral part of respiratory surveillance. a national aeronautics and space administration contract report on the occupational safety and health administration medical and workplace surveillance requirements and recommendations by the n ...20123772542
pulmonary function testing in the screening of workers: guidelines for instrumentation, performance, and interpretation.medical surveillance of workers exposed to potential respiratory hazards may be a valuable tool in early recognition and prevention of certain occupational lung diseases. the use of pulmonary function tests, particularly spirometry, has been widely accepted as an integral part of respiratory surveillance. a national aeronautics and space administration contract report on the occupational safety and health administration medical and workplace surveillance requirements and recommendations by the n ...20123772542
[detection of the thyrostatic drug methylthiouracil (mtu) using high performance liquid chromatography (hplc) and high performance thin layer chromatography in tissues and tissue extracts of fattening cattle]. 19863775348
[antiviral properties of various extracts of natural origin]. 20133777778
physiology: is it time to cross the new frontier? 20133781974
influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.a single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome p-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. this suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.19863784633
influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.a single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome p-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. this suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.19863784633
hydatid disease: research and control in turkana. ii. the role of immunological techniques for the diagnosis of hydatid disease.immunological studies have been applied to the immunodiagnosis of human hydatidosis in turkana and for the specific identification of echinococcus eggs, particularly in regard to their potential for the assessment of a hydatid control programme in the north-west of the district. a high rate of false negatives has been obtained with sensitive antibody tests for proven hydatid patients in turkana and presents problems for prevalence estimation in the population. a seroepidemiological study using s ...19863787677
unusual association of bone marrow necrosis, disseminated intravascular coagulation, and a rare 8;16 chromosomal translocation in an adult patient with acute nonlymphocytic leukemia.in a patient with acute nonlymphocytic leukemia of the classic type (fab subtype m2), three infrequently observed phenomena occurred together; bone marrow necrosis, disseminated intravascular coagulation, and an 8;16 chromosomal translocation. all three resolved with antileukemic therapy, only to reemerge when the leukemia relapsed, suggesting a causal relationship among these phenomena. such observations and the consistent application of cytogenetic studies to patients with leukemia may help el ...19873791177
immunoelectrophoresis in quality control of veterinary clostridial products.each year the pharmaceutical industry produces 150-250 batches of anti-clostridial vaccines and sera for veterinary use in the u.k. under medicines act requirements these products must be tested for potency before release to the public, such tests being performed in animals. the ministry of agriculture, as licensing authority, also carries out potency test on representative samples of these products. to avoid unnecessary use of animals we employ immunoelectrophoresis (iep) as a screening test. r ...19863792642
[the effect of neythumun in comparison with 2-cyanoethylurea on the white blood count of the rat].the stimulation effect of neythymun-sol f+k (nthy) and 2-cyanethylcarbamide (cec) on the leucocytopoesis was studied in 30 wistar rats and a moderate but significant increase in the total number of leucocytes was found. the increase produced by cec didn't prove significantly higher than that by nthy. after 32 d the blood count showed a substantial difference concerning the neutrophils with an increase from 3000 to 9000 without deviation to the left, which was found only under neythymun. this com ...19863797457
[neutralization of low molecular weight heparin kabi 2165 by protamine chloride].low molecular weight (lmw) heparin kabi 2165 possesses improved pharmacodynamic properties compared with conventional heparin. it is currently investigated in the prophylaxis of thromboembolism. the neutralization of kabi 2165 by protamine chloride was analysed after i.v. injection of both the agent and the antidot in healthy persons. the anticoagulant effects of the lmw heparin on the activated partial thromboplastin time, thrombin, and thromboelastography are completely and immediately suppres ...20133807263
immunization with heat-killed pneumococci, but not pneumococcal capsular polysaccharides, improves survival in splenectomized mice.immunization with pneumococcal capsular polysaccharides (pn ps) is advocated after splenectomy to decrease the risk of overwhelming sepsis. the clinical and experimental evidence for the benefit of immunization after splenectomy is controversial. various reports in the literature have claimed a benefit of immunization after splenectomy, but careful review of methodologies reveals that heat-killed pneumococci (pn) were used to immunize the experimental animals. since we have not been able to prot ...19873807350
[surgical indications in the asymptomatic gallstone].as long as long-term observations of operated and nonoperated patients with silent gallstones are missing, the question of general, differentiated or absent indication for operation in such cases cannot be answered by facts. to day only by 20% of people with gallstones are operated. 50-70% of those with silent gallstones probably remain free of complaints and symptoms during life. each case of symptomatic cholelithiasis must be operated as soon as possible, but a general indication for operation ...20133807594
influence of mouse genotype on responses of central biogenic amines to alcohol intoxication and aging.dopamine and serotonin responses to various periods of alcohol treatment have been followed in striatum and hippocampus of two inbred strains of mice and related to the effect of aging. a striking strain dependency was noted for chronic alcohol effects and also for senescence. for both neurotransmitters studied the c57bl strain loses tolerance to prolonged alcohol injury earlier than the balb/c strain. this loss of tolerance accompanying aging may be indicative of more widespread changes in cns ...19863814344
[the effect of a 100 kilometer run on total cholesterol, hdl-cholesterol, triglyceride and lipoprotein levels]. 20133824934
benoxaprofen--adverse reactions and monitoring in general practice.we report on the pattern of use of benoxaprofen (opren) in a single group practice for a period which included the complete clinical life of the drug. one hundred and seventy-two patients of the 6495 practice patients had been prescribed benoxaprofen, but 55% had only a small exposure (less than 20 g). recorded adverse reactions, of which none was serious, appeared in 25 patients. most were taking benoxaprofen for osteoarthritis (53%) or non-specific musculoskeletal pain (39.9%). the issue of a ...20133828196
[uv irradiation of autologous blood in the combined treatment of lymphedema of the lower extremities].based on the experience with the treatment of 144 patients the authors recommend to use transfusions of autologous blood subjected to uv irradiation in the complex treatment of lymphostasis of lower extremities.20133832538
nutritional status of the high esophageal cancer risk population in linxian, people's republic of china: effects of vitamin supplementation.plasma levels of nutrients in 196 individuals were assayed as part of a study of the feasibility of a nutrition intervention trial in linxian, a county in north central china with exceptionally high rates of esophageal cancer. high-performance liquid chromatography analyses of samples collected in april 1983 showed low (relative to united states standards) base-line levels for retinol, alpha-tocopherol, and beta- and alpha-carotene. repeat sampling in august 1983 revealed significantly increased ...20133834339
identification of two cases of bovine undifferentiated tumours (squamous cell carcinoma and adenocarcinoma) by electron microscopy.two cases of undifferentiated tumours were found in cows. electron microscopy revealed that one was an undifferentiated squamous cell carcinoma of unknown primary site and the other an undifferentiated adenocarcinoma of the lung.19853837797
[retinopathy of prematurity (vi)--changing the fundus findings of rop into the quantity evaluation]. 20133839623
diversity and structure of genes of the alpha family of mouse t-cell antigen receptor.we have analysed 19 complementary dna clones encoding the alpha-chain of the t-cell antigen receptor derived from thymic transcripts, and find that 15 of them contain partial or complete variable (v alpha) genes. seven of these genes cross-hybridize to over 40 germline v alpha gene segments in southern blot analyses. of the 19 joining (j alpha) sequences examined, 18 seem to be encoded by distinct gene segments, hence the repertoire of j alpha gene segments is much larger than those of the immun ...19853839904
delayed lactate clearance in patients surviving circulatory shock. 20133843372
[the professional responsibility of the nurse]. 20133845649
discharge planning: it's different at night. 20133851770
[keypoints in nursing observation of sle patients]. 20133853704
[a utility arch for maximum anchorage]. 20133870256
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