Publications

response to "an interpretive study describing the clinical judgment of nurse practitioners".		2009	2772453
in vivo biology of recombinant interleukin-2 infusion in sheep: cardiopulmonary manifestations of an intravascular immune-inflammatory response.	we have described the physiologic changes that occur in the conscious sheep during five days of dosing with ril-2. major effects noted were a decrease in systemic vascular resistance (vasodilation) accompanied by an increase in cardiac output (blood flow) and heart rate and a mild increase in pulmonary vascular resistance (vasoconstriction). body temperature increased and may have contributed to the peripheral vasodilation. lung microvascular fluid and protein flux increased following ril-2 admi ...	1989	2787783
[familial infantile nephrotic syndrome with ocular abnormalities].	two siblings born from consanguineous parents experienced infantile nephrotic syndrome with ocular and neurological abnormalities and a micropenis in the boy; both patients died before age 1. the opportunity to perform successively a renal biopsy and a two-step binephrectomy permitted a good histological follow-up. the lesions were characterized by mesangial involvement, followed by an extensive extracapillary proliferation and tubular dilatations with a high mitotic activity of the epithelium w ...	2009	2812971
[familial infantile nephrotic syndrome with ocular abnormalities].	two siblings born from consanguineous parents experienced infantile nephrotic syndrome with ocular and neurological abnormalities and a micropenis in the boy; both patients died before age 1. the opportunity to perform successively a renal biopsy and a two-step binephrectomy permitted a good histological follow-up. the lesions were characterized by mesangial involvement, followed by an extensive extracapillary proliferation and tubular dilatations with a high mitotic activity of the epithelium w ...	2009	2812971
directly repeated sequences associated with pathogenic mitochondrial dna deletions.	we determined the nucleotide sequences of junctional regions associated with large deletions of mitochondrial dna found in four unrelated individuals with a phenotype of chronic progressive external ophthalmoplegia. in each patient, the deletion breakpoint occurred within a directly repeated sequence of 13-18 base pairs, present in different regions of the normal mitochondrial genome-separated by 4.5-7.7 kilobases. in two patients, the deletions were identical. when all four repeated sequences a ...	2009	2813377
directly repeated sequences associated with pathogenic mitochondrial dna deletions.	we determined the nucleotide sequences of junctional regions associated with large deletions of mitochondrial dna found in four unrelated individuals with a phenotype of chronic progressive external ophthalmoplegia. in each patient, the deletion breakpoint occurred within a directly repeated sequence of 13-18 base pairs, present in different regions of the normal mitochondrial genome-separated by 4.5-7.7 kilobases. in two patients, the deletions were identical. when all four repeated sequences a ...	2009	2813377
[heparin therapy of pregnant women with placental insufficiency].	in the presence of low-dosage administrations of heparin the system of hemostasis was studied in 50 pregnant females with placental failure and the chronic dic syndrome. the efficacy of the treatment conducted was assessed with regard to the revealed levels of coagulation natural inhibitors, the products of fibrinogen-fibrin degradation, the degree of thrombocytic functional recovery and stabilization of the chronometric values of coagulation. the latter parameters considered together with the l ...	2009	2817276
morphometric analysis of the cell outlines of normal and polyomavirus-transformed fr 3t3 fibroblasts.	a method is described for the analysis of cell shape, using an image analyzer connected to a computer to assess the cell outline. a series of parameters to assess the contribution of large cytoplasmic expansions to cell morphology and to cell spreading on a planar substratum were used to quantify the visual morphologic differences between normal (nontransformed; n.3t3) and polyomavirus-transformed (py.3t3) fisher rat 3t3 fibroblasts. the results show that the py.3t3 fibroblasts are more spherica ...	1987	2822058
inhibitory effect of disulfiram (antabuse) on alcohol dehydrogenase activity.	we investigated the effect of disulfiram (antabuse) on the activity of alcohol dehydrogenase (ec 1.1.1.1) in vitro. we observed a time-dependent inhibition of this dehydrogenase by disulfiram and diethyldithiocarbamate similar to that obtained for aldehyde dehydrogenase (ec 1.2.1.3). these results suggest a possible explanation for various side effects observed in the clinical use of antabuse.	2009	2822291
inhibitory effect of disulfiram (antabuse) on alcohol dehydrogenase activity.	we investigated the effect of disulfiram (antabuse) on the activity of alcohol dehydrogenase (ec 1.1.1.1) in vitro. we observed a time-dependent inhibition of this dehydrogenase by disulfiram and diethyldithiocarbamate similar to that obtained for aldehyde dehydrogenase (ec 1.2.1.3). these results suggest a possible explanation for various side effects observed in the clinical use of antabuse.	2009	2822291
reinfection of guinea pigs with herpes simplex virus type 2: failure to establish a second latent ganglionic infection.	guinea pigs were infected with herpes simplex virus type 2 (hsv 2) and at various times thereafter reinfected at a different site with the same or a different strain of hsv 2. viruses were isolated from infected tissues either from the site of primary or secondary infection or from regional ganglia. viral isolates were characterised by dna fingerprinting using restriction endonucleases capable of differentiating between the virus strains used. the second infection resulted in a second site of pe ...	1987	2825951
the kappa agonists pd117302 and u50488 produce a biphasic effect on 24 hour food intake in the rat.	the effects of the selective kappa opioid receptor agonists pd117302 [(+/-)trans-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl-]benzo-[b]- thiophene-4-acetamide] and u50488 (trans-3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide) were investigated on food intake in non-deprived rats over a 24 hr period following subcutaneous administration. at doses of 2.5 mg/kg and 5 mg/kg, both pd117302 and u50488 initially increased food intake. between 6-24 hr, however, pd117302 (2.5-10 ...	1987	2829048
presynaptic opioid kappa-receptor and regulation of the release of met-enkephalin in the rat brainstem.	opioid kappa-agonists had much more potent inhibitory effects on the high k+-evoked met-enkephalin release from rat brain slices than did the mu- or delta-agonists. the opioid kappa- antagonist, mr2266 enhanced the evoked release of met-enkephalin to a greater extent than did mu- or delta-antagonists in vitro and had a potent analgesia in mice in vivo. these findings suggest that the release of met-enkephalin may be regulated in vitro and in vivo, mainly by presynaptic kappa-receptor-mediated me ...	1987	2829060
[suppurative meningitis in the newborn infant: experience with 107 cases in the ivory coast].	a retrospective study of 107 neonates with meningitis showed that in 45% of cases the condition occurred during the first 48 hours after birth, probably following a materno-foetal infection. male neonates accounted for 70% of the cases. in 15% of cases, the mothers previously had a known infectious disease and 55% of cases came from an unfavourable socio-economic environment. over 50% of the infants had to be resuscitated at birth. the majority of organisms isolated were gram-negative bacteria o ...	1988	2834748
two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.	insulin receptor complementary dna has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding. the patient is a compound heterozygote, having inherited two different mutant alleles of the insulin receptor gene. one allele contains a missense mutation encoding the substitution of glutamic acid for lysine at position 460 in the alpha subunit of the receptor. the second allele has a nonsense mutation causing premature cha ...	1988	2834824
two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.	insulin receptor complementary dna has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding. the patient is a compound heterozygote, having inherited two different mutant alleles of the insulin receptor gene. one allele contains a missense mutation encoding the substitution of glutamic acid for lysine at position 460 in the alpha subunit of the receptor. the second allele has a nonsense mutation causing premature cha ...	1988	2834824
ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues.	inositol 1,4,5-trisphosphate (ins p3) 3-kinase catalyzes the atp-dependent phosphorylation of ins p3 to inositol 1,3,4,5-tetrakisphosphate (ins p4). ca2+/calmodulin (cam)-sensitivity of ins p3 3-kinase was measured in the crude soluble fraction from rat brain and different anatomic regions of bovine brain. kinase activity was inhibited in the presence of egta (free ca2+ below 1 nm) as compared to ca2+ (10 microm free ca2+) or ca2+ (10 microm free ca2+) and cam (1 microm). ca2+-sensitivity was al ...	1988	2838022
legionella in power station cooling waters.		1985	2862486
therapeutic drug monitoring.		2010	2863512
multilayer-enzyme linked immunosorbent assay (ml-elisa) for detection of entamoeba histolytica trophozoite coproantigen.	multilayer elisa (ml-elisa) method for entamoeba histolytica trophozoite coproantigen was developed for diagnosis of amoebiasis and its usefulness vis-a-vis microscopic examination analysed for paired specimens from 87 patients from lucknow and hyderabad, india. all the stool specimens positive for trophozoites were also found to be positive in ml-elisa. out of a total 32 samples positive for cysts in microscopy 21 (65.62%) gave positive reactions for coproantigen. results on 26 samples drawn fr ...	1985	2867033
the integrated use of toxorhynchites amboinensis and ground-level ulv insecticide application to suppress aedes aegypti (diptera: culicidae).		2010	2877093
methimazole antagonises hla-dr3 suppression of aids.		2010	2880104
phosphoenolpyruvate carboxykinase as a selective indicator of ochratoxin a induced nephropathy.		1986	2881768
the leeuwenhoek lecture, 1986. environmental carcinogens and papillomaviruses in the pathogenesis of cancer.	in many areas of the world there is a geographically localized high incidence of alimentary and bladder cancer in cattle. studies in western scotland have demonstrated that this phenomenon is associated with ingestion of bracken fern. however, the affected animals and herds were shown also to have an unusually high infection rate of alimentary papillomas caused by a previously unrecognised bovine papillomavirus (bpv) and that these tumors could undergo malignant transformation. long-term field a ...	1987	2888116
high rate of plasmodium vivax relapse following treatment of falciparum malaria in thailand.	within two months of treatment for falciparum malaria, plasmodium vivax infections developed in 58 (33%) of 174 patients who had received a quinine or quinidine regimen and in 46 (32%) of 145 patients who had received mefloquine with inpatient follow-up of more than six weeks. the time to vivax relapse was significantly longer after mefloquine treatment (median 47 days, range 30-65) than after quinine or quinidine treatment (21 days, 15-36; p less than 0.0001). all patients remained outside area ...	1987	2889965
pancreatic abnormalities in type 2 diabetes mellitus.		2010	2893166
changes in serum enzymes in moderate drinkers after an alcohol challenge.	when 14 "moderate" drinkers abstained from alcohol for four weeks, the activity of gamma-glutamyltransferase (ggt; ec 2.3.2.2) in their serum showed a large decrease. immediately after the period of abstention, an orally given ethanol challenge of 1 g/kg produced a marked increase in serum ggt at 24 h, followed by a slow decline thereafter. aspartate amino-transferase activity in serum was significantly increased at 24 h; however, alkaline phosphate, alanine aminotransferase, and lactate dehydro ...	2010	2894905
hincii and kpni rflps for laminin b1 (lamb1) gene on chromosome 7.		1988	2901729
administration of gm1 ganglioside eliminates neuroleptic-induced sensorimotor deficits in mptp-treated mice.	injection of a low dose of haloperidol, that has no obvious behavioral effects in normal mice, produces akinesia, catalepsy, and sensory neglect in mptp-treated mice. gm1 ganglioside treatment eliminates all of these behavioral impairments and also partially restores striatal dopamine content. these observations suggest that the mptp-treated mouse may be a valuable model for studying mechanisms underlying parkinsonism and that administration of gm1 ganglioside may be an effective therapy.	1988	2903475
[prenatal diagnosis of duchenne muscular dystrophy using dna rflp analysis].		2010	2907413
facial nerve hemangioma.		2010	2916829
[a comparative study of clinics: terminal care personnel need communication, support and comfort to provide good care].		2010	2918796
autoimmunity after induction of neonatal tolerance to alloantigens: role of b cell chimerism and f1 donor b cell activation.	balb/c mice rendered tolerant by the neonatal injection of semiallogeneic (c57bl/6 x balb/c)f1 spleen cells develop features of autoimmune disease. the possible mechanisms involved in autoantibody production, particularly anti-dna antibodies, were investigated. in the first 5 wk, there was polyclonal b cell activation, as indicated by marked hypergammaglobulinemia, with a predominance of igg1 and an increased production of antihapten antibodies. igg1 anti-ssdna and anti-dsdna antibodies were det ...	2010	2940295
dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility.	in humans, plasma beta-endorphin levels rise during application of acute stressful stimuli (vertigo, cold pain, and transcutaneous electrical stimulation) that induce gut motor disturbances. whereas it is possible that circulating beta-endorphin participates in the mediation of these central effects on gut motility, its role cannot be established solely on the basis of changes in plasma levels. therefore, we designed the present study to investigate 1) the dose-related effects of intravenous syn ...	1986	2942039
structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model.	physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ...	1986	2946570
structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model.	physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ...	1986	2946570
reca protein-promoted atp hydrolysis occurs throughout reca nucleoprotein filaments.	when reca protein binds cooperatively to single-stranded dna to form filamentous nucleoprotein complexes, it becomes competent to hydrolyze atp. no correlation exists between the ends of such complexes and the rate of atp hydrolysis. atp hydrolysis is not, therefore, restricted to the terminal subunits on cooperatively bound reca oligomers, but occurs throughout the complex. similarly, during reca protein-promoted branch migration (during dna strand exchange), atp hydrolysis is not restricted to ...	1987	2951381
chromosomal assignments of genes coding for human leukocyte common antigen, t-200, and lymphocyte function-associated antigen 1, lfa-1 beta subunit.	five hybrids reactive with monoclonal antibodies against human leukocyte common antigen (t-200) and/or lymphocyte function-associated antigen 1 (lfa-1) beta subunit were obtained from the fusion of human blood lymphocytes or t-cell chronic lymphocytic leukemia cells with bw5147 mouse t-cell leukemia cells. chromosome analyses of 20 clones showed concordance between the presence of human chromosomes 1 and 21 and the expression of t-200 and lfa-1 beta subunit, respectively. confirmation of human c ...	1987	2955527
[prognosis of obstetrical hemorrhages in multiparous women].		2010	2955711
subfractionation of human t lymphocyte subpopulations by partitioning: surface heterogeneity of the okt8/leu2+ t cell subset.	human peripheral blood mononuclear cells (pbmc) were subjected to countercurrent distribution in a charge-sensitive dextran-poly (ethylene glycol) aqueous two-phase system. cells are thereby subfractionated on the basis of their charge-associated surface properties. the helper/inducer t cell subset (okt4/leu3+) has a single distribution curve with a low partition ratio (p). in contrast, the suppressor/cytotoxic (okt8/leu2+) subset is clearly heterogeneous and gives two peaks, one with a lower an ...	1987	2955975
jaundice. clinical pearls and perils revisited.	i recount some clinical "pearls and perils" to help reassess the contributions of abdominal ultrasound, cholangiography, needle biopsy of the liver, and laparoscopy. abdominal ultrasound demonstrates stones in the gallbladder in approximately 98% of cases, but in only 15% in the common bile duct, whereas computerized tomography scan reveals them in greater than or equal to 50%. on cholangiography a blood clot (in hemobilia) may closely resemble a common duct stone, as may spasm or tumor of the d ...	2003	2958535
transport of light in tissue in photodynamic therapy.		2010	2964653
identification of apolipoproteins involved in the interaction of human high density lipoprotein3 with receptors on cultured cells.	human high density lipoprotein (hdl), devoid of apolipoproteins e or b, binds with high affinity and specificity to cultured cells derived from several tissues. in order to investigate the ligand specificity of the putative receptor, we have performed competitive inhibition studies to identify the components of high density lipoprotein that bind to cell surfaces of rat adrenal cortical cells and human skin fibroblasts. radiolabeled hdl3 was displaced with unlabeled apolipoprotein-dimyristoylphos ...	1985	2982866
thio-analogues of inorganic pyrophosphate inhibit the replication of influenza virus a in vitro.	mono- and bisthiopyrophosphate can inhibit the replication of influenza virus a/x49 in madin-darby canine kidney (mdck) cells at concentrations at which no cytotoxic effect is observed after 3 days. the thiopyrophosphate analogues inhibit the rna transcriptase activity of this virus possibly by chelating with an essential metal ion in the transcriptase complex. [31p]nmr spectroscopy indicates that bisthiopyrophosphate coordinates to zinc through sulphur and magnesium through oxygen which may inf ...	1985	2990333
studies on the mechanism of action of omeprazole.	the effects of omeprazole on preparations of pig gastric (h+ + k+)-atpase have been studied. omeprazole was found to inhibit the (h+ + k+)-atpase activity in a time-dependent manner. inhibition was more pronounced at ph 6.1 compared with ph 7.4 and decreased as the concentration of (h+ + k+)-atpase preparation increased. the potency of omeprazole was therefore highly dependent upon the conditions used. when pre- incubated with (h+ + k+)-atpase preparation (30 micrograms protein/ml) for 30 min at ...	1985	2992525
proton beam therapy of uveal melanomas.		2010	3006647
proton beam therapy of uveal melanomas.		2010	3006647
[requirement of cyclic 3',5'-monophosphate in the production of a permeability increasing factor by vibrio cholerae].		1986	3018312
renal functional changes after converting enzyme inhibition or nitroprusside in hypertensive rats.		1987	3038467
passive protection of calves against experimental infection with salmonella typhimurium.	cows were vaccinated with formalin-killed salmonella typhimurium approximately seven weeks and two weeks before parturition to investigate whether passive immunity could protect their calves against experimental s typhimurium infection. after birth the calves were left with their dam for 48 hours and then separated and fed cold, stored colostrum from their own dam for a further eight days. oral challenge five days after birth with 10(8) s typhimurium did not result in the death of these calves e ...	1988	3061151
passive protection of calves against experimental infection with salmonella typhimurium.	cows were vaccinated with formalin-killed salmonella typhimurium approximately seven weeks and two weeks before parturition to investigate whether passive immunity could protect their calves against experimental s typhimurium infection. after birth the calves were left with their dam for 48 hours and then separated and fed cold, stored colostrum from their own dam for a further eight days. oral challenge five days after birth with 10(8) s typhimurium did not result in the death of these calves e ...	1988	3061151
neodymium: yag and argon laser iridotomy. long-term follow-up in a prospective, randomized clinical trial.	neodymium:yag (nd:yag) and argon laser iridotomies were compared in a prospective, randomized clinical trial of 43 patients with bilateral chronic pupillary-block glaucoma. all patients had one eye randomly assigned to argon and the fellow eye assigned to nd:yag laser treatment. follow-up ranged from 20 to 42 months. iridotomy closure was not observed in nd:yag-treated eyes, but nine (21%) argon iridotomies required retreatment. visual loss due to progression of laser-induced lens or corneal dam ...	2011	3062535
the untreated, shrinking simple bone cavity: case report.		2008	3064707
acute humoral rejection of an abo-unmatched liver allograft in a pediatric recipient.	acute humorally mediated rejection of organ allografts has long been recognized in kidney transplantation as the syndrome of hyperacute rejection. this reaction precludes renal transplantation across the major blood-group system and in many other instances in which preformed antibodies are present in the host. there is increasing evidence of the importance of humoral rejection in graft survival following liver transplantation. although the antibodies responsible for this process have seldom been ...	2010	3067237
acute humoral rejection of an abo-unmatched liver allograft in a pediatric recipient.	acute humorally mediated rejection of organ allografts has long been recognized in kidney transplantation as the syndrome of hyperacute rejection. this reaction precludes renal transplantation across the major blood-group system and in many other instances in which preformed antibodies are present in the host. there is increasing evidence of the importance of humoral rejection in graft survival following liver transplantation. although the antibodies responsible for this process have seldom been ...	2010	3067237
comparative densities of wuchereria bancrofti microfilaria in paired samples of capillary and venous blood.	concurrent finger-prick and venous blood samples were obtained from 43 patients infected with wuchereria bancrofti. microfilariae were counted in blood smears and on nuclepore filters. based on the numbers of microfilariae in 20-microliters finger-prick samples, an expected (theoretical) number of microfilariae in venous samples was calculated. this expected value was compared to the actual number of microfilariae present in venous blood. the actual number of microfilariae present ranged from 0. ...	1988	3067320
acrosomal proteinase activity of human spermatozoa and relation of results to semen quality.	an assay for measuring the acrosomal proteinase activity of human spermatozoa with the use of a microscope slide coated with a thin layer of gelatin as a protein substrate was developed and applied to study the semen of 82 males from infertile couples and 15 normal donors. acrosomal protease activity is indicated by a clear area of proteolyzed gelatin (halo) about the sperm head. probit analysis revealed two populations divided at a halo diameter of 14 microns. the patient samples were grouped a ...	1988	3068243
nursing's role in promoting health for elders in the community.		2011	3071500
prostaglandin research.		2011	3078573
[osmotic resistance of erythrocytes in cattle].		1986	3087113
cellular distribution of lysosomal hydrolase activities in the regenerating rat liver.	cathepsins b and d, beta-galactosidase, and acid phosphatase activities were found to be decreased in the regenerating rat liver, the reduction being maximal around the peak of hepatocyte mitoses (30 h). to investigate whether these changes could be heterogeneously distributed among hepatic cells, total cell populations from control or two-thirds hepatectomized rat livers were dissociated by the collagenase perfusion technique and analysed by different procedures. isopycnic centrifugation in a m ...	1986	3089641
effects of total parenteral nutrition on the development of intestinal endotoxemia in rats: a comparison between glucose and lipid.	the effects of parenteral nutrition (pn) and of the difference in the pn regimens between glucose and lipid emulsion on the development of endogenous endotoxemia were studied in 40 wister rats. endotoxemia was induced by occluding the superior mesenteric vein (smv) for 30 min. the plasma endotoxin in the portal blood at the time of the release of the smv occlusion and that in the arterial blood 10 min after the release were quantified. twenty of the 40 rats had received pn for 48 hr prior to the ...	1986	3091866
chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane.	two patients showed evidence of chronic cardiac toxicity after repeated exposure to 1,1,1-trichloroethane. in both cases there was circumstantial evidence of a deterioration after routine anaesthetic use of the related compound halothane. an adolescent boy who sniffed trichloroethane presented with multiple ventricular arrhythmias during tonsillectomy. follow up showed mild chronic left ventricular impairment. a 54 year old man had repeated industrial exposure to trichloroethane and deteriorated ...	1987	3105712
chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane.	two patients showed evidence of chronic cardiac toxicity after repeated exposure to 1,1,1-trichloroethane. in both cases there was circumstantial evidence of a deterioration after routine anaesthetic use of the related compound halothane. an adolescent boy who sniffed trichloroethane presented with multiple ventricular arrhythmias during tonsillectomy. follow up showed mild chronic left ventricular impairment. a 54 year old man had repeated industrial exposure to trichloroethane and deteriorated ...	1987	3105712
a retrospective analysis of a consecutive series of patients splenectomized for various hematologic disorders.	at our hospital, 47 out of 184 consecutive splenectomies performed over 7 recent years were carried out on patients afflicted with various hematologic diseases. the results of these 47 splenectomies were the subject of a careful retrospective analysis. the majority of the splenectomies (81%) were therapeutic. cytopenia, particularly thrombocytopenia, was the most common indication for surgery. as a whole, good therapeutic responses with rapid improvements in peripheral blood picture and/or dimin ...	2011	3107320
cerebral perfusion pressure: a hemodynamic mechanism of mannitol and the postmannitol hemogram.	sixteen patients each received infusions of 1 g of mannitol per kg over 5 to 10 minutes, and serial determinations of intracranial pressure (icp), systemic arterial blood pressure (sabp), central venous pressure, cerebral perfusion pressure (cpp), hematocrit, hemoglobin, serum na+, k+, osmolarity, and fluid balance were carried out for 4 hours. urine output was replaced volume for volume with 5% dextrose in 0.45% nacl solution. we tested the hypothesis that patients with high (greater than or eq ...	2010	3116451
localization of the binding sites of porcine tissue-type plasminogen activator and plasminogen to heparin.	to localize the binding region of porcine tissue-type plasminogen activator (ec 3.4.21.31) (t-plasminogen activator) to heparin, functionally active a and b chains (molecular mass of each 33 kda) were separated from the two-chain t-plasminogen activator after mild reduction and alkylation. the a chain bound to fibrin-sepharose, but not to heparin-sepharose. in contrast, the b chain showed amidase activity toward hd-ile-pro-arg-p-nitroanilide (s-2288) and a high affinity for heparin-sepharose, bu ...	1987	3120775
translational control of insp3-induced chromatin condensation during the early cell cycles of sea urchin embryos.	the cycles of dna synthesis and chromatin condensation in dividing cells are controlled by signals from the cytoplasm. changes in the concentration of free calcium (cai) in the cytoplasm control a variety of cellular functions and it has thus been suggested that observed variations in cai during the cell cycle may be the cytoplasmic signal that co-ordinates nuclear and cytoplasmic division. we show here that increases in cai induced by the calcium-releasing second messenger inositol 1,4,5-tripho ...	2011	3127728
[resorption and metabolic utilization of d-[alpha-15n]lysine and l-[alpha-15n]lysine after oral administration, with special reference to the metabolism of intestinal bacteria].	absorption of d-[alpha-15n]lysine and l-[alpha-15n]lysine following an oral single pulse labelling at a dosage of 5 mg 15n'/kg body weight was compared in four subjects aged 4 to 14 months. the wastages of 15n' in the faeces ranged from 0.3 to 5% of the input implying comparably high absorption rates of both the lysine enantiomers. only about 7.6% of the 15n from the alpha-amino groups were found in the urine after loading with l-[alpha-15n]lysine. in contrast, about 80.2% of the 15n' dose from ...	2011	3128286
tripelennamine enhances buprenorphine-, but not pentazocine-induced hyperactivity in mice.	the opioid agonist-antagonist pentazocine (1-30 mg/kg) and the partial agonist buprenorphine (0.05-0.25 mg/kg) were tested, alone or in combination with the histamine h1-receptor antagonist tripelennamine (1, 2.5, 5 or 10 mg/kg), on locomotor activity in mice of the cd-1 strain. when given alone, pentazocine produced slight and non-dose-related activity increments, while buprenorphine induced strong and dose-related locomotor stimulation. tripelennamine slightly increased activity by itself and ...	2011	3137594
the costs of crime and the benefits of drug abuse treatment: a cost-benefit analysis using tops data.		2011	3140032
ovarian carcinoma: abdominopelvic irradiation following reexploration.	twenty patients with ovarian cancer, who following reexploration were left with residual disease nodules of less than 2 cm diameter, received abdominopelvic irradiation. of these patients 18 had previous chemotherapy. fifteen patients completed treatment, 13 of whom had prior chemotherapy. six of the 18 patients with invasive tumors were alive and disease free 18-53 months postradiotherapy, while only 4 patients had died at the time of follow-up. no patient with residual nodules greater than 1 c ...	2011	3141249
anomalies in composition of uremic lipoproteins isolated by gradient ultracentrifugation: relative enrichment of hdl in apolipoprotein c-iii at the expense of apolipoprotein a-i.	using a discriminating gradient separation technique combined with careful analysis of lipid and apolipoprotein (apo) composition, serum lipoproteins of 20 chronically uremic patients have been compared with those of 19 normal controls matched for age and sex. in uremic subjects, serum vldl concentration was markedly increased. these particles were enriched in protein and cholesterol and relatively poor in triglycerides (tg). they contained more frequently apo b-48, and a decreased proportion of ...	2011	3145749
[nursing and informatics. the prospects and implications].		2011	3149012
[the effect of intraperitoneal administration of isoprenaline on atpase activity in the brain of rats of different ages].		1985	3155871
bilateral pelvic lymphadenectomy and radical retropubic prostatectomy for stage c or d1 adenocarcinoma of the prostate: possible beneficial effect of adjuvant treatment.	limited clinical stage c (t3 nx m0) disease can be treated surgically, and morbidity can be acceptable. when appropriate adjuvant therapy (orchiectomy and/or radiation) is administered, residual cancer can be controlled locally for at least a limited period. the incidence of local progression in pathologic stage c or d1 disease may be negligible after early adjuvant orchiectomy and/or radiation treatment. the combination of immediate orchiectomy and radical prostatectomy has been shown to limit ...	2011	3173496
double-blind study with fenticonazole or bifonazole lotions in pityriasis versicolor.	the efficacy of fenticonazole 2% lotion was studied in patients suffering from pityriasis versicolor in a double-blind comparison with bifonazole 1% lotion, both applied once daily for three weeks. forty-six patients were recruited and randomly allocated to one or other treatment group. clinical and mycological examinations, performed at baseline and at weekly intervals, have shown an excellent response to both treatments. two cases of mild transient desquamation were reported in the fenticonazo ...	2007	3182117
[psychological evaluation of diabetic students and their families].	a population of 29 diabetic school children has been studied with the purpose of evaluating the repercussion the disease has on the psychosocial development of the child. eysenck's inventory of personality, achembach's ipcds and the drawing of the human figure have been employed as psychological test. the sociological aspects are valued through interviewing and questionnaires. the outstanding conclusions are: 1. diabetes does not condition the development of a specific personality. 2. psychiatri ...	1988	3190018
zonal distribution of prostatic adenocarcinoma. correlation with histologic pattern and direction of spread.	for 104 prostate glands obtained at radical prostatectomy for adenocarcinoma, we mapped the tumor outline and determined the tumor volume, grade, and location relative to the transition zone boundary and location of the central zone. among the 88 cancers whose probable zone of origin could be identified, 68% arose in the peripheral zone, 24% arose in the transition zone, and 8% arose in the central zone. transition zone carcinomas had usually been diagnosed by transurethral resection (tur) and o ...	2011	3202246
aids: opportunistic diseases and their physical assessment.		2011	3235987
cyclosporin a treatment in children with minimal change nephrotic syndrome and focal segmental glomerulosclerosis.	in a pilot study 23 children with nephrotic syndrome were treated with cyclosporin a (cs) for 6-45 months. 8 children suffered from steroid dependent minimal change nephrotic syndrome (mcns) and had experienced at least one course with cytotoxic drugs, but had relapsed thereafter. 2 children had diabetes mellitus type i with nephrotic syndrome and 13 children had steroid resistant focal segmental glomerulosclerosis (fsgs). cs was started with 100 mg/m2/day in two doses and increased stepwise to ...	2011	3236762
[pathophysiologic observations of facial neuralgia].	the different etiology and pathogenesis of face-neuralgiae requires a spezific therapy of the respective illness. new aspects are formed in the last years in the so-called idiopathic neuralgia. she has good chances with the therapy through the jannetta-operation. the evident mechanical lesion by compression, the ephaptic genesis and the special pain-characterization with trigger-attacks not support the "idiopathic". this is called "ictal neuralgia". the paper attempts pathophysiological to expla ...	2012	3244807
fatty acid components of larval ostrea edulis (l.): importance of triacylglycerols as a fatty acid reserve.	1. the fatty acid profiles of all of the acyl-lipid classes of 1- and 10-day-old european oyster ostrea edulis (l.) larvae were studied in detail by capillary gas-liquid chromatography. 2. no significant changes in the fatty acids were detected between the different larval stages. 3. total lipid fatty acids showed a higher degree of unsaturation than previously reported. this may be a consequence of the extraction of lipids from the living tissues without sample storage. 4. one-third of the tria ...	2011	3248373
metaphyseal dysostosis schmidt type.		2010	3251840
koro-like syndrome in maltese subject on the basis of chronic schizophrenia.		2011	3252941
koro-like syndrome in maltese subject on the basis of chronic schizophrenia.		2011	3252941
evaluation of low-intensity transcutaneous electrical nerve stimulation in combination with aspirin for reduction of controlled thermal sensation.	reductions in cutaneous thermal sensation produced by placebo, aspirin, transcutaneous electrical nerve stimulation, and transcutaneous electrical nerve stimulation plus aspirin were compared in 60 normal volunteers. the combination of transcutaneous electrical nerve stimulation plus aspirin produced a statistically significant reduction as compared with placebo. the results suggest this treatment combination may provide levels of analgesia useful for completion of minor dental procedures.	2012	3266912
[obstetrics and gynecology of the innsbruck medical school].		2012	3285598
evaluation of developmental toxicity data: a discussion of some pertinent factors and a proposal.	there is currently no well-accepted standard method for evaluation of developmental toxicity data. this paper presents one approach to the evaluation of developmental toxicity data. we initially identify some pertinent factors that influence the interpretation of animal data and summarize the literature pertaining to these factors. such factors include the quality and quantity of data and the relationship between maternal and developmental toxicity. we proceed with a discussion of quantitative a ...	2012	3287508
[changes in s-adenosylmethionine metabolism in liver cirrhosis].		2012	3287509
cervical cancer in nuns and prostitutes: a plea for scientific continence.		2011	3290397
psychophysiological effects of methylphenidate (ritalin).		2012	3313484
coordinative interactions in the separation of insulin and its derivatives by high-performance liquid chromatography.	the effects of various inorganic cations and anions on the chromatographic behaviour of insulin and its derivatives have been investigated. it was shown that on an octadecylsilica column at a given eluent composition the retention of insulins depends primarily on the nature of the anions. the cations have a secondary effect, depending on their size and coordination ability. the mechanism of the effect of the ions is complex. it includes the formation of ion pairs, their influence on dissociation ...	1987	3323216
use of lytic bacteriophage for actinomyces viscosus t14v as a probe for cell surface components mediating intergeneric coaggregation.	a lytic bacteriophage for actinomyces viscosus t14v (the reference strain for actinomyces coaggregation group a) was isolated from raw sewage. this phage, designated bf307, also lysed the t14v-derived nonfimbriated mutant pk455-2 as well as a. viscosus mg-1 and t14av but not the other serotype 2 or serotype 1 strains of this species that were tested or any of nine actinomyces naeslundii isolates. phages bf307 belonged to bradley morphological group c and was similar in appearance to the a. visco ...	1988	3335409
an experimental study on ethanol elimination at subphysiological temperatures.	hepatocytes isolated from fed and fasted rats have been used to study the rate of ethanol elimination at different incubation temperatures. in the presence of exogenous pyruvate, hepatocytes from fed and 42 hr fasted rats, eliminated ethanol at 37 degrees by a rate of 11.6 +/- 3.4 and 6.4 +/- 0.8 nmol/min./mg of cell protein (+/- s.d.; n = 5), respectively, which are comparable to the rates obtained in vivo. the ethanol oxidation rate in cells from rats of both nutritional states correlated line ...	1988	3353352
an experimental study on ethanol elimination at subphysiological temperatures.	hepatocytes isolated from fed and fasted rats have been used to study the rate of ethanol elimination at different incubation temperatures. in the presence of exogenous pyruvate, hepatocytes from fed and 42 hr fasted rats, eliminated ethanol at 37 degrees by a rate of 11.6 +/- 3.4 and 6.4 +/- 0.8 nmol/min./mg of cell protein (+/- s.d.; n = 5), respectively, which are comparable to the rates obtained in vivo. the ethanol oxidation rate in cells from rats of both nutritional states correlated line ...	1988	3353352
laryngoscope blade breakage during intubation.		2012	3356060
a multicentre study of flumequine in the treatment of urinary tract infections.	the efficacy and safety of flumequine were evaluated in the treatment of 121 cases uncomplicated (65.5%) and complicated (34.5%) urinary tract infections (uti) when given as a dose of 400 mg bd. duration of treatment ranged from 7-15 days, with a mean of 10. thirty days post-therapy, cure persisted in 92.3% of the patients with uncomplicated uti and in 53.7% of those with complicated uti. relapse or re-infection occurred in 34.1% of the patients with complicated uti, and in 12.2%, the infecting ...	2012	3356617
autosomal recessive inheritance of nager acrofacial dysostosis.	nager acrofacial dysostosis is a variant of mandibulofacial dysostosis with severe micrognathia, malar hypoplasia, and radial limb defects. most cases are sporadic, but autosomal recessive inheritance has been suggested. a family is reported in which two sibs are affected by this syndrome, presenting further evidence for autosomal recessive inheritance. the recognition of this syndrome as a distinct entity has important implications. after the birth of a child with orofacial malformations sugges ...	2005	3367347
tachycardia during the onset of one-kidney, one-clip renal hypertension: role of the renin-angiotensin system and av3v tissue.	we have previously demonstrated a transitory tachycardia during the early phase of one kidney, one clip (1k1c) hypertension in the rat, when the basal heart rate (hr) is measured daily under resting conditions. in the present study, in control rats, marked tachycardia (406 +/- 11 vs 320 +/- 4 bpm during the control period) was observed on the first day of electrolytic lesion of the anteroventral third ventricle (av3v) region. the basal hr declined progressively thereafter and was normal 14 days ...	1988	3370491