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identification of a 43-kda outer membrane protein of fusobacterium necrophorum that exhibits similarity with pore-forming proteins of other fusobacterium species.a pair of primers was designed in an attempt to amplify outer membrane protein (omp) gene of fusobacterium necrophorum based on nucleotide sequence of the omp of fusobacterium nucleatum. further analysis was performed to characterize its molecular properties and phylogeny in the genus fusobacterium. we identified a predicated 43kda outer membrane protein (43k omp) in f. necrophorum, which showed the same properties as other pore-forming proteins of gram-negative anaerobic bacteria according to a ...201323433684
antibacterial effect of different root canal sealers on three bacterial species.bacteria persisting in the root canal system may thwart endodontic therapy. it is therefore interesting to know whether clinically available root canal sealers have an antimicrobial effect. the objective of the present in vitro study was to investigate the antibacterial effect of various sealers on the endodontologically detectable species enterococcus faecalis (e. faecalis), fusobacterium nucleatum (f. nucleatum) and porphyromonas gingivalis (p. gingivalis).201323523285
advancement in the routine identification of anaerobic bacteria by maldi-tof mass spectrometry.we evaluated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) biotyper as a tool for the identification of anaerobic bacteria compared with 500 base-pair (bp) 16s ribosomal ribonucleic acid (rrna) gene sequencing analysis, which is considered to be the "gold standard" method. a total of 484 anaerobic bacteria were retrieved from the clinical specimens of 318 pediatric patients. molecular identification resulted in 18 genera and 51 species. the most prev ...201323584672
[evaluation on antimicrobial efficacy of fufang bingpeng irrigant: an in vitro study].to evaluate the antimicrobial efficacy of fufang bingpeng irrigant and bingpeng irrigant on four endodontic pathogen bacteria.201323991570
subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis.there is a bidirectional relationship between periodontal disease and type-2 diabetes mellitus (dm). inflammatory mediators may negatively affect glycemic control, and increased glucose levels and resultant glycation end-products may alter the host response against bacterial infection. however, no agreement has been reached regarding the effect of dm on periodontal subgingival microbiota. therefore, the purpose of the present study was to compare the subgingival biodiversity in deep periodontal ...201322762355
in vitro activity of biapenem plus rpx7009, a carbapenem combined with a serine β-lactamase inhibitor, against anaerobic bacteria.biapenem is a carbapenem being developed in combination with rpx7009, a new inhibitor of serine β-lactamases. biapenem was tested alone and in combination with fixed concentrations of rpx7009 by agar dilution against 377 recent isolates of anaerobes. a separate panel of 27 isolates of bacteroides spp. with decreased susceptibility or resistance to imipenem was also tested. comparator drugs included meropenem, piperacillin-tazobactam, ampicillin-sulbactam, cefoxitin, ceftazidime, metronidazole, c ...201323529731
modulation of quaternary structure and enhancement of ligand binding by the k-turn of tandem glycine riboswitches.most known glycine riboswitches have two homologous aptamer domains arranged in tandem and separated by a short linker. the two aptamers associate through reciprocal "quaternary" interactions that have been proposed to result in cooperative glycine binding. recently, the interaptamer linker was found to form helix p0 with a previously unrecognized segment 5' to the first aptamer domain. p0 was shown to increase glycine affinity, abolish cooperativity, and conform to the k-turn motif consensus. w ...201323249744
specificity of antimicrobial peptide ll-37 to neutralize periodontopathogenic lipopolysaccharide activity in human oral fibroblasts.the antimicrobial peptide ll-37 is known to have a potent lipopolysaccharide (lps)-neutralizing activity in various cell types. because of observed heterogeneity within periodontopathogenic lps, the authors hypothesized that ll-37 had specificity to neutralize such lps activity. the present study, therefore, aims to investigate the lps-neutralizing activity of ll-37 to various periodontopathogenic lps in interleukin-8 (il-8) production after challenging them in human oral fibroblasts.201322443521
adhesion of aggregatibacter actinomycetemcomitans and fusobacterium nucleatum on bioactive tio(2) surfaces.bioactive tio(2) coatings have been found to enhance fibroblast adhesion and gingival attachment on the titanium surfaces, but no information is available whether the coatings also promote the adhesion of periodontal pathogens.201322220677
development of quantitative real-time pcr primers for detecting 42 oral bacterial species.in this study, we introduced species-specific quantitative real-time pcr (qpcr) primers designed based on a dna-dependent rna polymerase beta-subunit gene (rpob) for detecting 42 oral bacterial species. the specificity of the qpcr primers was confirmed by conventional pcr with the genomic dnas of 73-79 strains regarding 73-75 bacterial species including the type strain for the target species. the standard curves revealed the lower detection limits of 42 bacterial species-specific qpcr primers ra ...201323689247
in vitro antimicrobial effects of two antihalitosis mouth rinses on oral pathogens and human tongue microbiota.the aim of the study was to compare the antimicrobial activity of a mouth rinse containing chlorhexidine and cetylpyridinium chloride (mr1) with a stannous fluoride-based mouth rinse (mr2) in vitro.201323368885
bacterial antagonism against periodontopathogens.the aim of the current study is to compare the prevalence of commensal bacteria, with beneficial properties, for healthy and diseased individuals and additionally to examine the inhibitory effect of some commercial dietary probiotics on periodontopathogens, comparing this inhibitory effect to that of orally derived beneficial bacteria.201322897652
phototoxic effect of blue light on the planktonic and biofilm state of anaerobic periodontal pathogens.the purpose of this study was to compare the phototoxic effects of blue light exposure on periodontal pathogens in both planktonic and biofilm cultures.201323678390
comparative evaluation of subgingival plaque microflora in pregnant and non-pregnant women: a clinical and microbiologic study.gingival changes in pregnancy have been attributed to changes in the subgingival biofilm related to hormonal variations.201323633772
characterization and in vitro properties of oral lactobacilli in breastfed infants.lactobacillus species can contribute positively to general and oral health and are frequently acquired by breastfeeding in infancy. the present study aimed to identify oral lactobacilli in breast and formula-fed 4 month-old infants and to evaluate potential probiotic properties of the dominant lactobacillus species detected. saliva and oral swab samples were collected from 133 infants who were enrolled in a longitudinal study (n=240) examining the effect of a new infant formula on child growth a ...201323945215
photodynamic biofilm inactivation by sapyr--an exclusive singlet oxygen photosensitizer.prevention and control of biofilm-growing microorganisms are serious problems in public health due to increasing resistances of some pathogens against antimicrobial drugs and the potential of these microorganisms to cause severe infections in patients. therefore, alternative approaches that are capable of killing pathogens are needed to supplement standard treatment modalities. one alternative is the photodynamic inactivation of bacteria (pib). the lethal effect of pib is based on the principle ...201323891675
effects of short-chain fatty acids on actinomyces naeslundii biofilm formation.actinomyces naeslundii is an early colonizer and has important roles in the development of the oral biofilm. short-chain fatty acids (scfa) are secreted extracellularly as a product of metabolism by gram-negative anaerobes, e.g. porphyromonas gingivalis and fusobacterium nucleatum; and the scfa may affect biofilm development with interaction between a. naeslundii and gram-negative bacteria. our aim was to investigate the effects of scfa on biofilm formation by a. naeslundii and to determine the ...201323731652
in vivo study of the initial bacterial adhesion on different implant materials.biofilm formation on implant materials plays a major role in the aetiology of periimplantitis. the aim of this study was to examine in vivo the initial bacterial adhesion on six different implant materials.201323694907
effect of metalloporphyrins on red autofluorescence from oral bacteria.the aim of this study was to assess the red autofluorescence from bacterial species related to dental caries and periodontitis in the presence of different nutrients in the growth medium. bacteria were grown anaerobically on tryptic soy agar (tsa) supplemented with nutrients, including magnesium-porphyrins from spinach and iron-porphyrins from heme. the autofluorescence was then assessed at 405 nm excitation. on the tsa without additives, no autofluorescence was observed from any of the species ...201323659237
association of plasma 25-hydroxyvitamin d concentrations and pathogenic oral bacteria in postmenopausal females.previous findings of an association between 25-hydroxyvitamin d [25(oh)d] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin d. to the best of the authors' knowledge, no study has investigated the association between 25(oh)d and pathogenic oral bacteria, a putative cause of periodontal disease.201324261910
porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of prommp9 and its activation.recent epidemiological studies have revealed a significant association between periodontitis and oral squamous cell carcinoma (oscc). furthermore, matrix metalloproteinase 9 (mmp9) is implicated in the invasion and metastasis of tumour cells. we examined the involvement of porphyromonas gingivalis, a periodontal pathogen, in oscc invasion through induced expression of prommp and its activation. prommp9 was continuously secreted from carcinoma sas cells, while p. gingivalis infection increased pr ...201323991831
a new type of na(+)-driven atp synthase membrane rotor with a two-carboxylate ion-coupling motif.the anaerobic bacterium fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of na⁺. here, we demonstrate that this ion-motive force is directly coupled to atp synthesis, via an f₁f₀-atp synthase with a novel na⁺ recognition motif, shared by other human pathogens. molecular modeling and free-energy simulations of the rotary element of the enzyme, the c-ring, indicate na⁺ specificity in physiological settings. consistently, activity measurements showed na⁺ s ...201323824040
antimicrobial activity of ethanol extracts of laminaria japonica against oral microorganisms.laminaria japonica is a brown alga, which is consumed widely in korea, japan, and china. this study investigated the antimicrobial activity of ethanol extracts of l. japonica against oral microbial species to assess the possible application of l. japonica extracts in dental care products. the minimal inhibitory concentration (mic) and minimal bactericidal concentration (mbc) were determined in culture medium using a microdilution method. the mics of ethanol extracts of l. japonica with oral stre ...201323583539
antibacterial activity of probiotic candidates for oral health.the aim of this study was to determine the probiotic potential of autochthonous oral lactobacilli. for this, 66 strains were screened for antibacterial activity against two cariogenic strains (streptococcus mutans and actinomyces viscosus) and two periodontopathogenic strains (fusobacterium nucleatum and porphyromonas gingivalis). the inhibitory activity was investigated with the agar overlay technique. positive results led us to explore some mechanisms of action. the ability to produce h(2)o(2) ...201323211763
analysis of bacterial flora associated with peri-implantitis using obligate anaerobic culture technique and 16s rdna gene sequence.to analyze and characterize the predominant bacterial flora associated with peri-implantitis by using culture techniques under obligate anaerobic conditions and 16s rdna gene sequences.201324278920
the predominant bacteria isolated from radicular cysts.to detect predominant bacteria associated with radicular cysts and discuss in light of the literature.201324011184
microbiological evaluation of bacterial and mycotic seal in implant systems with different implant-abutment interfaces and closing torque values.the aim of this study was to evaluate the possible leakage of 3 species of bacteria (streptococcus sanguinis, fusobacterium nucleatum, and actinomyces odontolyticus) and of candida albicans and candida glabrata in osseointegrated implants with different implant-abutment interface (iai) geometry.201323782848
oral epithelial cell responses to multispecies microbial biofilms.this report describes the use of a novel model of multispecies biofilms to stimulate profiles of cytokines/chemokines from oral epithelial cells that contribute to local inflammation in the periodontium. streptococcus gordonii (sg)/s. oralis (so)/s. sanguinis (ss) and sg/fusobacterium nucleatum (fn)/porphyromonas gingivalis (pg) biofilms elicited significantly elevated levels of il-1α and showed synergistic stimulatory activity compared with an additive effect of the 3 individual bacteria. only ...201323300185
anaerobic co-culture of mesenchymal stem cells and anaerobic pathogens - a new in vitro model system.human mesenchymal stem cells (hmscs) are multipotent by nature and are originally isolated from bone marrow. in light of a future application of hmscs in the oral cavity, a body compartment with varying oxygen partial pressures and an omnipresence of different bacterial species i.e. periodontitis pathogens, we performed this study to gain information about the behavior of hmsc in an anaerobic system and the response in interaction with oral bacterial pathogens.201324223777
oral community interactions of filifactor alocis in vitro.filifactor alocis is a gram positive anaerobe that is emerging as an important periodontal pathogen. in the oral cavity f. alocis colonizes polymicrobial biofilm communities; however, little is known regarding the nature of the interactions between f. alocis and other oral biofilm bacteria. here we investigate the community interactions of two strains of f. alocis with streptococcus gordonii, fusobacterium nucleatum, porphyromonas gingivalis and aggregatibacter actinomycetemcomitans, organisms w ...201324098460
antimicrobial activity of isothiocyanates (itcs) extracted from horseradish (armoracia rusticana) root against oral microorganisms.the antimicrobial activity of isothiocyanates (itcs) extracted from horseradish root was investigated against oral microorganisms: 6 strains of facultative anaerobic bacteria, streptococcus mutans, streptococcus sobrinus, lactobacillus casei, staphylococcus aureus, enterococcus faecalis and aggregatibacter actinomycetemcomitans; one strain of yeast, candida albicans, and 3 strains of anaerobic bacteria, fusobacterium nucleatum, prevotella nigrescens, and clostridium perfringens. the itcs extract ...201324077540
the connection between ruptured cerebral aneurysms and odontogenic bacteria.patients with ruptured saccular intracranial aneurysms have excess long-term mortality due to cerebrovascular and cardiovascular diseases compared with general population. chronic inflammation is detected in ruptured intracranial aneurysms, abdominal aortic aneurysms and coronary artery plaques. bacterial infections have been suggested to have a role in the aetiology of atherosclerosis. bacteria have been detected both in abdominal and coronary arteries but their presence in intracranial aneurys ...201323761916
porphyromonas gingivalis, treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case-control study.to explore the associations between the presence of periodontal pathogens and the expression of toll-like receptors (tlr-2 and tlr-4) in the placental tissue of patients with hypertensive disorders compared to the placentas of healthy normotensive patients.201323711357
peptides: β-cyclodextrin inclusion compounds as highly effective antimicrobial and anti-epithelial proliferation agents.the use of antimicrobial peptides (amps) as therapeutic agents for periodontal infections has great advantages, such as broad spectrum of action, low toxicity, and limited bacterial resistance. however, their practical use is limited because of the large amount of peptide required to exercise the microbicidal function.201323510146
salivary detection of periodontopathic bacteria in fanconi's anemia patients.fanconi's anemia (fa) is characterized by bone marrow failure and can lead to infections such as periodontal disease. the aim of this study was to compare the prevalence of four periodontopathic bacteria including aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, fusobacterium nucleatum and treponema denticola in saliva samples from children with and without fa. paraffin-stimulated saliva samples were collected from 71 children and adolescents, aged 6-18 years old. the samples wer ...201324055631
the antibacterial activity of various saturated and unsaturated fatty acids against several oral pathogens.the antibacterial activity of various saturated fatty acids (sfa) and unsaturated fatty acids (usfa) against different oral pathogens which are implicated in the cause of dental caries, stomatitis, gingivitis, and periodontitis was examined. the saturated fatty acids pa, sta and ara, and the unsaturated omega-7 fatty acids pla and omega-9 fatty acids oa showed either none to low antimicrobial activity against all of the 12 oral pathogenic strains used in this study. in contrast, the omega-3 pufa ...201324640241
a specular reflection arising from the ventricular wall: a potential pitfall in the diagnosis of germinal matrix hemorrhage.reflection artifacts may complicate the diagnosis of intracranial hemorrhage in preterm neonates. a linear focus of bright echoes in the region of the germinal matrix at or anterior to the caudothalamic grooves, often seen on parasagittal scans, may be mistaken for a germinal matrix hemorrhage but is actually a reflection of the ultrasound beam at the wall of the lateral ventricle. cranial sonograms of 100 preterm infants were retrospectively analyzed and categorized with regard to presence and ...20133884829
optimization of ultrasonic transducers.the so-called klm-model for ultrasonic transducers is employed to optimize transducer design. some new performance characteristics are defined which change monotonically with design parameters. these characteristics are based on the area of the envelope of the echo waveform produced by the transducer and of the corresponding amplitude spectrum. the efficiency of the transducer is defined by the round trip energy factor. the performance characteristics are used in a composite performance measure, ...20133881869
the midwifery examination system--a matter for concern. 20133634171
[ambulatory mass screening for preventing and improving the outcome of acute pneumonia in military personnel]. 20133576995
the causes and consequences of chronic hepatic venous outflow obstruction.the causes of chronic hepatic venous outflow obstruction are membranous obstruction of the inferior vena cava (group 1), hepatic venous ostial obstruction (group 2) and partial hepatic venous ostial obstruction (group 3). at the h. f. verwoerd and kalafong hospitals, pretoria, 155 cases have been diagnosed, almost all in the first group. over 50% of the patients in this series had hepatocellular carcinoma; this association appears to be a constant finding world-wide. the most likely cause is a c ...20133603285
trends in teenage childbearing 1970-83. 20133576441
metastatic disease of the spine. 20133745256
physiologic regulation and pathologic disorders of fibrinolysis.physiologic fibrinolysis is a reparative process that occurs in response to hemostatic plug or thrombus formation. the final enzymatic step, fibrin proteolysis, results from a coordinated interaction of enzymes and inhibitors, which produces effective action at the site of the disease and spares the proteins of the blood or uninvolved parts of the vascular system. the agent of fibrinolysis, the enzyme plasmin, is derived from its zymogen (plasminogen) through limited proteolysis effected by plas ...20133546075
the presidents. gerald desmond timmons 1962-1963. 20133549832
late corneal grafting in congenitally opaque corneas. 20133894096
the structure, function and evolution of cytochromes. 20133881803
combined active and passive immunotherapy in honeybee-sting allergy.five honeybee sting-allergic patients in whom bee venom immunotherapy (vit) had previously been stopped because of repeated allergic side effects (se) were resubmitted to bee vit after pretreatment with beekeeper gammaglobulin. the tolerated bee venom dose was increased five to 800 times after this passive immunotherapy, and the maintenance dose of 100 micrograms of honeybee venom (bv) was reached in all patients after 6 to 15 days of a rush hyposensitization. the igg response to bv was not supp ...20133722631
the relationship of movement and time to older adults' functional health.the relationship of movement (measured by walking cadence) and time (measured by perceived duration) to functional health was investigated in a sample of community-based, white, older women (n = 114). significant relationships were found between health and movement, and between movement and time. speed, inherent in both movement and time, may be an important qualitative dimension of functional health. walking cadence shows the most promise for use as an inexpensive, noninvasive, easy-to-use clin ...20133636945
[clinical effects of hyperthermia in patients with carcinoma of the esophagus--a multi-institutional cooperative study]. 20133782986
[on an unusual case of adenocystic carcinoma of the breast]. 20134312699
[on an unusual case of adenocystic carcinoma of the breast]. 20134312699
vitamin and mineral usage in adult family practice patients. 20134056668
patient recall systems. 20133824240
on display. technical innovations and innovators, imaging-related services and educational literature at rsna '87. radiological society of north america. 20133659347
prognosis of alcoholic cirrhosis in the presence and absence of alcoholic hepatitis.liver biopsy specimens (178 percutaneous and 39 transjugular) were assessed from 217 consecutive patients with alcoholic liver disease, 77 noncirrhotics and 140 cirrhotics, whose cases were followed for 5 yr. cirrhotic patients were categorized into two groups, with and without "hepatitis" using a criteria to define "hepatitis" that included only degrees of inflammation, necrosis, and mallory bodies that had a prognostic weight in terms of mortality in 1 yr. this classification resulted in a sha ...20133781189
[sterilization of couples]. 20133639609
[hormone dependence and steroid receptors in adenocarcinomas of the endometrium].the degree of hormone-dependence of endometrial cancers may be evaluated by the presence and the rate of estradiol and mostly progesterone receptors in an endometrial fragment. the most differentiated tumors have a high receptor content, while anaplastic cancers are most of the time without them. they must be systematically determined regardless of other prognostic factors enabling to evaluate the prognosis and guide the treatment. it is presently facilitated by the method of immunochemical titr ...20133602807
co-occurrence of anaerobic bacteria in colorectal carcinomas.numerous cancers have been linked to microorganisms. given that colorectal cancer is a leading cause of cancer deaths and the colon is continuously exposed to a high diversity of microbes, the relationship between gut mucosal microbiome and colorectal cancer needs to be explored. metagenomic studies have shown an association between fusobacterium species and colorectal carcinoma. here, we have extended these studies with deeper sequencing of a much larger number (n = 130) of colorectal carcinoma ...201324450771
toll-like receptor 2-dependent activity of native major outer membrane protein proteosomes of chlamydia trachomatis.chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the etiologic agent of blinding trachoma. intracellular signaling pathways leading to host cell inflammation and innate immunity to chlamydia include those mediated by toll-like receptors (tlrs) and nucleotide binding oligomerization domain 1 (nod1) protein. in epithelial cells, tlr-dependent signaling contributes to local immune responses via induction of inflammatory mediators. there is evidence that tlr3, tlr ...201323132491
effect of controlled-release periochip™ on clinical and microbiological parameters in patients of chronic periodontitis.the aim of the present study was to evaluate and compare the clinical and microbiological effectiveness of periochip™ as an adjunct to scaling and root planing (srp) with srp alone in patients with chronic periodontitis.201324174754
quantitative analysis of periodontal pathogens present in the saliva of geriatric subjects.at present, information regarding periodontal disease in geriatric patients is scarce. the purpose of this study was to quantify the periodontal pathogens present in the saliva of korean geriatric patients and assess the relationship between the bacterial levels and the periodontal condition.201324040571
bacterial community development in experimental gingivitis.current knowledge of the microbial composition of dental plaque in early gingivitis is based largely on microscopy and cultural methods, which do not provide a comprehensive description of oral microbial communities. this study used 454-pyrosequencing of the v1-v3 region of 16s rrna genes (approximately 500 bp), and bacterial culture, to characterize the composition of plaque during the transition from periodontal health to gingivitis. a total of 20 healthy volunteers abstained from oral hygiene ...201323967169
mobile microbiome: oral bacteria in extra-oral infections and inflammation.the link between oral infections and adverse systemic conditions has attracted much attention in the research community. several mechanisms have been proposed, including spread of the oral infection due to transient bacteremia resulting in bacterial colonization in extra-oral sites, systemic injury by free toxins of oral pathogens, and systemic inflammation caused by soluble antigens of oral pathogens. mounting evidence supports a major role of the systemic spread of oral commensals and pathogen ...201323625375
short-term microbiological effects of scaling and root planing and essential-oils mouthwash in chinese adults.to assess the short-term effect of scaling and root planing (srp) and essential-oils mouthwash on the levels of specific bacteria in chinese adults.201323645178
antibody and t cell responses to fusobacterium nucleatum and treponema denticola in health and chronic periodontitis.the characteristics of the t cell response to the members of oral flora are poorly understood. we characterized the antibody and t cell responses to fada and td92, adhesins from fusobacterium nucleatum, an oral commensal, and treponema denticola, a periodontal pathogen, respectively. peripheral blood and saliva were obtained from healthy individuals and patients with untreated chronic periodontitis (cp, n = 11 paris) and after successful treatment of the disease (n = 9). the levels of antigen-sp ...201323335969
impact of early colonizers on in vitro subgingival biofilm formation.the aim of this study was to investigate the impact of early colonizing species on the structure and the composition of the bacterial community developing in a subgingival 10-species biofilm model system. the model included streptococcus oralis, streptococcus anginosus, actinomycesoris, fusobacterium nucleatum subsp. nucleatum, veillonella dispar, campylobacter rectus, prevotella intermedia, porphyromonas gingivalis, tannerella forsythia, and treponema denticola. based on literature, we consider ...201324340084
the surface layer of tannerella forsythia contributes to serum resistance and oral bacterial coaggregation.tannerella forsythia is an anaerobic, gram-negative bacterium involved in the so-called "red complex," which is associated with severe and chronic periodontitis. the surface layer (s-layer) of t. forsythia is composed of cell surface glycoproteins, such as tfsa and tfsb, and is known to play a role in adhesion/invasion and suppression of proinflammatory cytokine expression. here we investigated the association of this s-layer with serum resistance and coaggregation with other oral bacteria. the ...201323357386
[soldiers in white smocks]. 20133898571
[soldiers in white smocks]. 20133898571
child health status and risk factors. 20133882631
loss of substance of dental composite restorations. 20133861433
dental syndromes in medical genetics. 20133861432
the tongue. 2. developmental anomalies and coated tongue. 20133861431
sonography of the normal and abnormal intact lumbar spinal canal. 20133880985
sonography of the normal and abnormal intact lumbar spinal canal. 20133880985
controversies in the actions of digitalis substances: are all digitalis derivatives alike? 20133905878
comparison of the effectiveness of two topical anesthetics and a placebo in reducing injection pain. 20133867659
[limitations of conventional mechanical ventilation in the treatment of acute respiratory failure]. 20133747112
low indoor temperatures and morbidity in the elderly.low ambient temperatures are particularly harmful to the elderly and in the winter in the uk temperatures in some dwellings may fall to 6 degrees c. the world health organization recommends a minimal indoor temperature of 18 degrees c and a 2-3 degrees c warmer minimal temperature for rooms occupied by sedentary elderly, young children and the handicapped. below 16 degrees c, resistance to respiratory infections may be diminished. both low and high relative humidities promote respiratory illness ...20133751747
[possibilities and limits of the study of tumor markers in the after-care of patients with ovarian cancer]. 20133770529
[ventricular fibrillation in the initial phase of acute myocardial infarct].in order to determinate the incidence, predictivity and prognosis of ventricular fibrillation in the early phase of acute myocardial infarction a series of 301 patients with acute myocardial infarction consecutively assisted by the mobile coronary care unit of florence was analyzed. 151 patients (50.2%) received intensive care within 2 hours from the onset of the symptoms, 75 patients (24.9%) received intensive care between the second and sixth hour. 38 patients (12.6%) had at least one episode ...20134007366
[ventricular fibrillation in the initial phase of acute myocardial infarct].in order to determinate the incidence, predictivity and prognosis of ventricular fibrillation in the early phase of acute myocardial infarction a series of 301 patients with acute myocardial infarction consecutively assisted by the mobile coronary care unit of florence was analyzed. 151 patients (50.2%) received intensive care within 2 hours from the onset of the symptoms, 75 patients (24.9%) received intensive care between the second and sixth hour. 38 patients (12.6%) had at least one episode ...20134007366
[biological profile of the 1st 4 hours of a thrombolytic treatment combining urokinase with lysyl-plasminogen].the authors study the biological variations which accompany an oral, thrombolytic treatment in which urokinase and lysyl-plasminogen are combined. fibrinogen, the products of degradation of fibrinogen or fibrin, plasminogen and rapid alpha 2 antiplasmin are studied as a function of time. two dimensional electrophoreses were carried out at precisely determined times. the combination of the two therapeutic agents causes the appearance of plasmin in the circulation, but it is neutralised by its rap ...20133832977
likelihood ratio vs a multivariate model. 20133813825
[patients without vocalizing function. on assistance of alaryngeal patients from the postoperative period to the time of social rehabilitation]. 20133845289
a fluid-phase routine method for the detection of insulin-anti-insulin complexes.a fast routine method has been devised to measure circulating insulin-anti-insulin complexes. the principle lies in the calculation of the difference between the insulin binding capacity of the free antibody and that of the total amount of insulin antibody. the ph of 1 aliquot of serum was lowered to 3 by adding glycine-hcl buffer. free insulin was removed by charcoal precipitation and the ph was again neutralized by the simple addition of naoh; the final dilution of serum was 1/5. radiolabelled ...20133816046
[the use of occupational law in solving problems at obstetric-gynecologic facilities]. 20133811411
malignant melanoma arising intradermally in a small congenital nevus of an adult.the occurrence of a malignant melanoma in a small congenital nevus is a rare event. a malignant melanoma arising intradermally in a small congenital nevus in an adult has not been previously reported. the clinical implications and known information about the prognosis of intradermal malignant melanomas are discussed.20133771902
[the lung in cardiopathies]. 20133836616
[outline of the university education on the air: a new type of education for the era of life-long education]. 20133846685
nonhuman primate model for regional wave travel and reflections along aortas.arterial pulse transmission and wave reflections were studied in five mature anesthetized baboons (papio anubis) using multisensor micromanometry. simultaneous pressures were recorded from the left ventricle and every 10 cm along the aorta and its terminal branches, and flow velocity was measured in the aortic root. aortic input impedance and regional foot-to-foot and apparent phase velocities were calculated. aortography provided dimensional data for local reflection coefficients. regional foot ...20133618804
autoinducer 2 of fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens.periodontitis is initiated by bacteria in subgingival biofilms, which are composed mostly of gram-negative anaerobes. autoinducer 2 (ai-2) is a universal quorum sensing (qs) molecule that mediates intergeneric signalling in multispecies bacterial communities and may induce biofilm formation. as fusobacterium nucleatum is the major coaggregation bridge organism that links early colonising commensals and late pathogenic colonisers in dental biofilms via the accretion of periodontopathogens, we hyp ...201322633049
ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to fcγr and tlr agonists.periodontitis, a ubiquitous chronic inflammatory disease, is associated with reduced antioxidant defences and neutrophil hyperactivity in terms of reactive oxygen species (ros) generation. its phenotype is thus characterized by oxidative stress. we have determined the effect of antioxidant micronutrients ascorbate and α-tocopherol on neutrophil ros generation. peripheral neutrophils from periodontally-healthy individuals (n = 20) were challenged with phorbol myristate acetate, igg-opsonised stap ...201322914919
maternal oral origin of fusobacterium nucleatum in adverse pregnancy outcomes as determined using the 16s-23s rrna gene intergenic transcribed spacer region.fusobacterium nucleatum, a common gram-negative anaerobe prevalent in the oral cavity, possesses the ability to colonize the amniotic cavity and the fetus. however, f. nucleatum may also be part of the vaginal microbiota from where it could reach the amniotic tissues. due to the heterogeneity of f. nucleatum, consisting of five subspecies, analysis at the subspecies/strain level is desirable to determine its precise origin. the aims of this study were: (i) to evaluate the use of the 16s-23s rrna ...201323002071
mycoplasma pneumoniae preceding lemierre's syndrome due to fusobacterium nucleatum complicated by acute epstein-barr virus (ebv) infectious mononucleosis in an immunocompetent host.we report an unusual case of lemierre's syndrome due to a rare species of fusobacterium, that is, fusobacterium nucleatum preceded by mycoplasma pneumoniae pharyngitis and followed later by epstein-barr virus infectious mononucleosis.201322464641
protective potential of non-dialyzable material fraction of cranberry juice on the virulence of p. gingivalis and f. nucleatum mixed infection.periodontitis is a polymicrobial infectious disease. a novel potential chemical treatment modality may lie in bacterial anti-adhesive materials, such as cranberry juice fractions. the aim of this study is to explore the effect of high molecular weight cranberry constituent (non-dialyzable material [ndm]) on the virulence of a mixed infection with porphyromonas gingivalis and fusobacterium nucleatum in mice.201323030239
association between oral malodour and periodontal disease-related parameters in the general population.to determine the association between halitosis detection and periodontal status in systemically healthy non-smokers and to assess whether halitosis was related to quantities of fusobacterium nucleatum and porphyromonas gingivalis on the tongue dorsum.201322339235
micronutrient modulation of nf-κb in oral keratinocytes exposed to periodontal bacteria.chronic periodontal diseases are characterised by a dysregulated and exaggerated inflammatory/immune response to plaque bacteria. we have demonstrated previously that oral keratinocytes up-regulate key molecular markers of inflammation, including nf-κb and cytokine signalling, when exposed to the periodontal bacteria porphyromonas gingivalis and fusobacterium nucleatum in vitro. the purpose of the current study was to investigate whether α-lipoic acid was able to abrogate bacterially-induced pro ...201322890546
diagnosis and treatment of fusobacterium nucleatum discitis and vertebral osteomyelitis: case report and review of the literature.case report.201323132536
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